[Hub]/) : Traits : Forced vital capacity (FVC), Best measure :

chr9:96,326,127-100,114,913

Best TWAS P=2.16e-18 · Best GWAS P=5.84e-23 conditioned to 0.0119

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial ERCC6L2 0.22 0.18 enet 39 0.18 5.2e-14 4.7 5.3 1.5e-07 -0.05 1.00 0.00 FALSE
2 GTEx Artery Tibial RP11-435O5.5 0.09 0.04 lasso 2 0.02 7.3e-03 8.6 -8.4 3.8e-17 -0.44 0.25 0.06 FALSE
3 GTEx Breast Mammary Tissue CDC14B 0.16 0.02 enet 21 0.02 3.7e-02 6.2 -6.2 5.2e-10 -0.01 0.02 0.95 FALSE
4 GTEx Breast Mammary Tissue ERCC6L2 0.17 0.02 lasso 4 0.03 1.2e-02 4.7 5.4 6.2e-08 -0.03 0.28 0.03 FALSE
5 GTEx Cells EBV-transformed lymphocytes AAED1 0.17 0.02 lasso 3 0.04 2.4e-02 6.1 5.5 3.4e-08 0.00 0.03 0.65 FALSE
6 GTEx Cells Transformed fibroblasts ERCC6L2 0.19 0.02 enet 34 0.16 4.1e-12 4.6 5.4 8.3e-08 0.02 0.98 0.00 FALSE
7 GTEx Esophagus Muscularis ERCC6L2 0.15 0.10 lasso 6 0.08 8.8e-06 4.8 5.5 4.2e-08 -0.01 0.87 0.01 TRUE
8 GTEx Heart Atrial Appendage ERCC6L2 0.16 0.05 enet 22 0.10 4.6e-05 4.8 5.2 2.6e-07 0.02 0.59 0.02 FALSE
9 GTEx Heart Atrial Appendage RP11-435O5.4 0.18 0.00 lasso 5 0.00 6.2e-01 3.7 -6.0 1.9e-09 0.07 0.07 0.06 TRUE
10 GTEx Liver PTCH1 0.25 0.06 enet 11 0.03 4.9e-02 9.8 8.7 2.2e-18 0.91 0.01 0.94 TRUE
11 GTEx Nerve Tibial HSD17B3 0.14 0.00 enet 20 0.00 2.4e-01 6.0 5.6 1.8e-08 0.04 0.04 0.74 FALSE
12 GTEx Nerve Tibial ZNF367 0.10 0.05 lasso 3 0.02 7.9e-03 6.1 5.9 4.9e-09 0.04 0.04 0.94 FALSE
13 GTEx Spleen PTCH1 0.33 0.08 lasso 8 0.18 1.9e-05 -1.1 6.7 2.7e-11 0.64 0.05 0.76 FALSE
14 GTEx Testis HABP4 0.19 0.22 lasso 9 0.21 1.1e-09 5.9 6.0 2.0e-09 0.02 0.04 0.96 FALSE
15 GTEx Testis C9orf3 0.15 0.00 enet 18 0.00 2.4e-01 -1.5 -5.2 2.2e-07 -0.10 0.06 0.11 TRUE
16 GTEx Thyroid CDC14B 0.15 0.10 lasso 5 0.08 5.3e-07 5.9 -5.7 1.0e-08 -0.03 0.06 0.94 FALSE
17 NTR Blood PTCH1 0.04 0.02 blup 433 0.02 4.1e-08 8.8 6.7 1.5e-11 0.64 0.02 0.98 FALSE
18 NTR Blood ZNF169 0.02 0.00 lasso 6 0.00 1.1e-02 -7.7 -5.4 7.9e-08 0.08 0.02 0.76 TRUE
19 YFS Blood HABP4 0.08 0.09 enet 24 0.11 5.9e-34 5.3 -5.5 3.6e-08 -0.04 0.74 0.26 FALSE
20 YFS Blood PTCH1 0.09 0.05 lasso 8 0.05 1.2e-15 8.8 8.4 6.7e-17 0.95 0.02 0.98 FALSE
21 The Cancer Genome Atlas Breast Invasive Carcinoma CDC14B 0.02 0.01 lasso 1 0.01 3.0e-03 6.1 -6.1 1.4e-09 -0.03 0.02 0.74 FALSE
22 The Cancer Genome Atlas Glioblastoma Multiforme CDC14B 0.16 0.17 blup 41 0.19 2.6e-06 6.1 -5.7 1.3e-08 0.00 0.02 0.97 FALSE
23 The Cancer Genome Atlas Glioblastoma Multiforme HABP4 0.08 0.06 blup 44 0.05 1.6e-02 5.9 -6.2 7.7e-10 -0.05 0.02 0.59 FALSE
24 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HABP4 0.02 0.02 blup 44 0.02 7.1e-03 6.1 6.0 1.7e-09 0.02 0.02 0.78 FALSE
25 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CDC14B 0.03 0.02 blup 42 0.02 2.1e-03 6.1 -6.1 8.2e-10 -0.03 0.02 0.84 FALSE
26 The Cancer Genome Atlas Brain Lower Grade Glioma CDC14B 0.05 0.06 lasso 5 0.06 6.5e-07 6.2 -6.0 2.6e-09 -0.01 0.02 0.98 FALSE
27 The Cancer Genome Atlas Brain Lower Grade Glioma HABP4 0.05 0.08 lasso 5 0.08 6.9e-09 6.3 -6.3 3.1e-10 -0.04 0.02 0.98 TRUE
28 The Cancer Genome Atlas Prostate Adenocarcinoma PTCH1 0.02 0.01 blup 54 0.02 1.1e-03 7.9 -6.3 3.8e-10 -0.19 0.06 0.04 TRUE
29 The Cancer Genome Atlas Stomach Adenocarcinoma CDC14B 0.08 0.02 blup 41 0.04 1.0e-03 3.9 -5.6 2.1e-08 -0.05 0.02 0.69 FALSE
30 The Cancer Genome Atlas Thyroid Carcinoma CDC14B 0.05 0.07 blup 42 0.08 4.8e-08 6.2 -6.0 2.2e-09 -0.02 0.02 0.98 FALSE