TWAS hub - ZCCHC24

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1170	0.0410	0.00300	0.006	NA	0.025	NA	0.025	1.0e-01	NA	3.6e-03	NA	0.0034
2	GTEx	Heart Atrial Appendage	0.1940	0.0580	0.00049	0.006	NA	0.022	NA	0.022	1.6e-01	NA	3.6e-02	NA	0.0350
3	GTEx	Skin Sun Exposed Lower leg	0.0910	0.0350	0.00510	-0.003	NA	0.001	NA	-0.003	9.4e-01	NA	2.3e-01	NA	0.6600
4	TCGA	Bladder Urothelial Carcinoma	0.0630	0.0310	0.00890	-0.002	0.008	-0.002	NA	-0.003	5.7e-01	0.06200	6.2e-01	NA	0.6800
5	TCGA	Breast Invasive Carcinoma	0.0268	0.0115	0.00056	0.008	0.016	0.008	NA	0.005	6.5e-03	0.00020	6.2e-03	NA	0.0240
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0667	0.0246	0.00020	0.046	0.024	0.035	NA	0.034	6.5e-06	0.00085	6.7e-05	NA	0.0001

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Sitting height	12.1	85.6	169.0	13.0	4.0	8.3	10.7	8.6	8.4
Standing height	10.3	102.0	213.2	14.6	1.8	10.3	10.8	6.2	11.6
Height	9.4	180.7	361.0	19.0	2.9	13.5	13.6	6.7	17.4
Hand grip strength (right)	9.0	24.5	44.5	6.7	1.6	4.3	6.2	5.9	3.0
Trunk fat-free mass	7.9	45.4	73.1	8.6	0.5	7.5	8.3	4.6	7.4
Trunk predicted mass	7.9	44.9	73.6	8.6	0.6	7.3	8.2	4.5	7.3
Whole body water mass	7.6	43.2	67.1	8.2	0.4	7.3	8.1	4.2	7.4
Whole body fat-free mass	7.4	42.6	65.8	8.1	0.4	7.3	8.0	4.2	7.4
Type 2 Diabetes (T2D) (2012)	7.3	8.5	12.7	3.1	-3.6	3.2	2.9	2.2	2.2
Hand grip strength (left)	7.3	19.3	36.1	6.0	2.0	3.8	5.6	4.5	3.1
Comparative height size at age 10	7.3	40.1	74.1	8.6	2.0	6.6	7.2	3.1	7.6
Arm predicted mass (right)	7.1	36.4	56.6	7.5	-0.3	6.7	7.3	4.1	6.8
Arm predicted mass (left)	6.9	35.2	55.5	7.3	-0.8	6.5	7.5	4.3	6.4
Forced vital capacity (FVC), Best measure	6.7	24.6	44.5	6.7	5.2	3.9	5.6	3.4	4.2
Arm fat-free mass (right)	6.6	33.9	53.0	7.3	-0.3	6.5	7.1	4.0	6.4
Basal metabolic rate	6.5	36.1	54.0	7.4	-0.3	6.9	7.2	3.8	7.0
Arm fat-free mass (left)	6.5	33.1	51.4	7.2	-0.5	6.3	7.1	4.1	6.3
Forced vital capacity (FVC)	6.4	24.5	44.5	6.7	4.7	3.6	5.7	4.0	4.3
Leg fat-free mass (right)	6.3	33.6	51.8	7.0	0.1	6.6	7.2	3.5	6.7
Leg predicted mass (right)	6.3	33.6	51.5	7.0	0.1	6.7	7.2	3.6	6.6
Heel T-Score	5.9	46.9	73.4	-8.5	-0.8	-8.6	-8.2	-2.5	-7.9
Leg fat-free mass (left)	5.7	30.3	43.8	6.6	-0.0	6.6	6.6	3.1	6.5
Leg predicted mass (left)	5.7	30.0	43.2	6.6	0.1	6.5	6.6	3.1	6.5
Forced expiratory volume in 1-second (FEV1), Best measure	5.2	16.6	27.8	5.3	4.8	2.7	4.4	2.4	4.0
Blood Platelet Count	5.1	59.0	90.1	-9.5	3.7	-9.2	-8.2	-3.6	-9.2
Diabetes (self-reported)	5.1	7.9	38.9	-0.5	-6.2	1.8	1.9	0.0	-1.1
Type 2 Diabetes (T2D) (2018)	5.0	9.3	47.5	0.8	-6.9	1.6	2.1	0.9	0.2
Forced expiratory volume in 1-second (FEV1)	4.9	16.6	27.7	5.3	4.6	2.8	4.3	2.9	4.0
Forced expiratory volume in 1-second (FEV1), predicted	4.7	9.8	17.3	4.2	0.0	3.1	3.3	2.5	3.8
Headache pain in last month	4.4	7.5	13.5	-3.7	0.3	-2.8	-3.2	-2.3	-2.9
Illnesses of father: Heart disease	4.3	6.0	18.3	-2.7	-4.3	0.2	-2.7	-1.1	-1.4
Bipolar Disorder (2018)	4.1	6.5	11.6	3.1	3.4	1.0	2.2	3.0	1.8
Diabetes diagnosed by doctor	4.1	6.7	32.3	0.4	-5.7	1.7	2.1	0.2	-0.0
Hair/balding pattern: Pattern 4	3.7	8.9	13.1	3.6	-3.2	3.0	3.1	1.0	3.2
Medication: Paracetamol	3.7	6.1	11.3	-2.9	1.6	-2.8	-3.4	-2.2	-1.5
Fed-up feelings	3.5	6.3	12.3	-2.1	1.9	-3.5	-2.6	-2.2	-2.5
Heel bone mineral density (BMD) T-score, automated (left)	3.5	7.8	14.7	-2.6	0.5	-3.7	-3.4	-0.2	-3.8
Weight	3.4	16.5	28.4	4.4	-2.2	4.9	4.1	2.5	5.3
Peak expiratory flow (PEF)	3.4	7.9	12.0	3.1	3.2	2.7	2.6	1.0	3.5
Medication: Metformin	3.3	4.7	21.3	0.2	-4.6	1.7	1.9	0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	3.1	7.2	14.0	-2.7	0.8	-3.7	-3.0	-1.2	-3.2
Lupus	3.0	4.6	12.3	-2.6	-1.1	-1.6	-3.5	-1.9	-1.1
Heart disease (mother)	2.9	3.6	9.6	2.0	-0.3	3.1	1.2	1.9	1.6
Medication: Paracetamol	2.9	4.5	9.7	-2.4	1.6	-2.1	-3.1	-2.0	-1.1
Vitamin and mineral supplements	2.8	3.7	8.9	-3.0	-1.6	0.2	-2.1	-0.3	-2.5
Qualifications: CSEs or equivalent	2.8	3.8	8.3	-2.9	-1.7	-0.8	-1.6	-1.0	-2.7
Multivitamins +/- minerals	2.6	3.3	6.8	2.6	2.3	-0.2	1.8	1.0	1.8
Relative age of first facial hair	2.5	5.2	12.4	-2.5	-2.0	-2.5	-1.5	0.3	-3.5
Waist Hip Ratio (WHR)	2.4	10.7	43.2	-2.7	-6.6	0.7	-1.9	-2.1	-2.3
Relative age voice broke	2.4	3.6	7.2	-2.0	-0.7	-2.7	-1.7	-0.5	-2.6
Knee pain experienced in last month	2.3	3.6	16.1	-1.4	-4.0	-0.7	-1.0	-1.5	-0.0
Pain experienced in last month	2.3	3.9	7.1	2.6	-0.1	2.7	0.9	2.2	2.0
Crohns Disease (2017)	2.2	4.9	20.0	-0.6	2.5	-4.5	0.4	-1.0	-1.2
Medication: Lansoprazole	2.2	2.5	7.4	-1.9	-2.7	0.5	-1.2	-1.6	0.2
Migraine (self-reported)	2.2	2.7	4.3	-2.1	-0.6	-1.6	-1.6	-1.8	-1.8
Illnesses of father: None of the above (group 1)	2.2	2.8	10.2	1.9	3.2	-0.4	1.3	0.5	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	5.7	-1.8	0.4	-0.5	-2.2	-2.4	0.9
Medication: Gliclazide	2.1	2.4	6.9	0.8	-2.6	2.1	1.1	0.6	0.9
Hearing difficulty/problems: Yes	2.0	3.1	6.5	-2.5	-1.0	-0.5	-2.4	-2.0	-1.0
Diabetes (mother)	2.0	2.5	9.2	-0.2	-3.0	0.4	1.2	1.9	-0.7
Exposure to tobacco smoke at home	2.0	2.2	4.7	2.2	-0.1	0.6	2.2	1.6	0.8
Alcohol drinker status: Previous	1.9	2.2	5.7	-2.4	-1.2	-1.2	-1.0	-1.4	-1.1
Irritable Bowel Disease (IBD)	1.8	4.4	14.7	-1.0	1.9	-3.8	0.2	-0.4	-2.7
Number of live births	1.8	2.6	5.0	-2.2	-1.5	-1.4	-2.1	-1.3	-0.6
Fractured/broken bones in last 5 years	1.8	2.3	3.9	2.0	-1.8	1.6	1.7	0.9	0.6
Lung FVC	1.7	8.6	44.8	-0.8	6.7	-1.6	0.6	0.5	-1.8
Hip circumference	1.7	7.4	15.4	2.5	-1.9	3.7	1.9	1.5	3.9
Birth weight of first child	1.7	3.1	6.6	1.9	0.8	2.2	2.6	1.1	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	5.7	1.5	2.4	1.1	1.1	0.7	1.2
Mineral and other dietary supplements	1.7	2.3	3.3	-1.8	-1.8	0.4	-1.8	-1.8	-0.9
Ever taken oral contraceptive pill	1.7	1.9	4.0	1.4	2.0	1.0	1.0	0.9	1.5
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.8	-1.7	0.9	-2.0	-0.9	-0.9	-1.9
HbA1C	1.6	1.8	3.5	-0.8	-1.1	-1.9	-0.4	-1.9	1.2
Trunk fat mass	1.6	7.0	16.8	2.2	-3.3	2.7	1.2	0.7	4.1
Waist circumference	1.6	5.7	26.2	-0.8	-5.1	2.2	-0.6	-0.2	1.4
Leg fat percentage (right)	1.6	5.6	19.4	-2.5	-4.4	-0.9	-2.5	-0.8	-0.3
Pack years adult smoking proportion	1.5	2.4	5.7	1.5	0.7	2.0	1.2	0.5	2.4
Medication for pain relief, constipation, heartburn	1.5	2.6	5.3	1.8	0.5	2.1	2.3	1.6	0.4
Breast cancer (self-reported)	1.5	1.8	4.2	1.6	0.0	2.0	1.5	1.1	0.7
Leg fat percentage (left)	1.5	5.6	21.5	-2.4	-4.6	-1.0	-2.2	-0.5	-0.4
Pack years of smoking	1.5	2.2	6.3	1.3	0.5	1.9	1.1	0.1	2.5
Depressed Affect (Nagel 2018)	1.4	2.9	6.7	-1.1	1.5	-2.6	-1.9	-1.2	-1.5
Prostate Cancer	1.4	2.0	6.2	-1.4	0.4	-2.5	-1.1	-0.7	-1.5
Angina	1.4	1.9	2.7	-1.5	-1.6	-1.5	-1.4	-0.9	-1.2
Medication: Atenolol	1.4	1.7	4.6	-1.7	-0.7	-0.9	-1.0	0.6	-2.1
Financial difficulties in last 2 years	1.4	1.9	5.8	-0.7	2.1	-2.4	-0.8	-0.5	-0.5
Worrier / anxious feelings	1.4	2.7	7.4	-1.2	-0.2	-2.7	-2.0	-1.6	-1.0
Glaucoma (self-reported)	1.4	1.7	3.0	-1.7	0.5	-1.7	-1.0	-1.2	-1.2
Neck or shoulder pain in last month	1.4	2.0	3.1	-1.7	-1.8	-1.7	-1.1	-0.7	-1.0
Mean time to correctly identify matches	1.4	2.6	5.5	-1.5	-2.3	-1.5	-1.5	-1.7	-0.9
Overall health rating	1.4	2.9	8.3	-1.8	-2.9	-1.7	-1.1	-1.1	-0.8
Hearing aid user	1.4	1.6	3.0	-1.5	0.6	-0.2	-1.3	-1.4	-1.7
Medication: Lisinopril	1.4	1.8	5.4	-1.0	-2.3	1.7	-1.0	-0.2	-0.6
Irritability	1.4	2.3	7.8	-0.7	2.8	-1.0	-1.1	-0.8	-1.7
Heart disease (siblings)	1.4	1.7	4.5	-0.6	-2.1	1.4	0.2	-1.7	0.5
Crohns Disease (2012)	1.3	2.2	7.3	0.2	1.7	-2.7	1.4	-0.9	-0.1
Blood Red Count	1.3	12.7	41.3	-2.9	-3.3	-6.4	-1.9	1.6	-3.1
Systolic Blood Pressure	1.3	6.6	14.6	3.8	2.0	0.8	2.6	3.5	1.1
Hypothyroidism (self reported)	1.3	3.0	9.4	-1.4	-3.1	1.9	-1.4	-0.8	-0.6
Alcohol usually taken with meals	1.3	2.0	5.4	-0.1	2.3	-2.1	-0.3	-1.4	0.0
Hair/balding pattern: Pattern 3	1.3	2.0	6.8	-1.1	-0.6	-1.1	-1.6	-2.6	0.0
Comparative body size at age 10	1.3	3.5	9.7	-2.4	3.1	-1.5	-1.1	0.4	-1.3
Number of children fathered	1.3	1.5	2.7	-1.5	1.0	-1.5	-0.2	-0.7	-1.6
Qualifications: College or University degree	1.3	4.1	8.7	3.0	1.0	2.2	1.9	0.3	2.6
Angina (self-reported)	1.3	1.7	2.5	-1.4	-1.4	-1.6	-1.2	-0.6	-1.4
Alcohol intake frequency.	1.3	3.0	5.1	-2.0	-2.2	0.4	-2.0	-2.3	-0.5
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.0	-1.3	0.8	-2.0	-0.4	-0.5	-1.7
Ever smoked	1.3	2.2	8.4	1.6	2.9	-0.1	1.3	0.8	0.1
Primary Biliary Cirrhosis	1.2	1.8	3.9	-1.8	1.2	0.9	-1.1	-2.0	-0.3
Medication: Simvastatin	1.2	1.8	9.0	-0.8	-3.0	-0.1	-0.0	-0.3	-0.9
Neuroticism score	1.2	2.6	5.9	-0.7	0.7	-2.4	-2.1	-2.0	-0.6
Medication: Omeprazole	1.2	1.4	2.7	-1.3	0.9	-1.6	-0.6	-0.6	-1.6
Whole body fat mass	1.2	5.1	11.4	1.4	-3.4	2.3	0.9	0.6	3.3
Age at last live birth	1.2	1.7	3.6	-1.3	0.8	-1.9	-1.9	-0.8	-0.4
Bipolar Disorder or Schizophrenia	1.1	2.7	7.9	2.1	2.8	0.7	0.2	1.6	1.0
Ulcerative Colitis (UC)	1.1	2.0	6.7	-0.9	1.3	-1.6	-0.2	0.7	-2.6
Blood White Count	1.1	7.8	12.5	-2.8	-3.5	-3.3	-3.0	-1.3	-2.2
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.2	1.3	1.3	0.7	1.5	0.5	1.5
Systolic blood pressure, automated reading	1.1	3.2	7.0	2.0	1.2	1.2	1.4	2.6	1.8
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.3	1.0	-0.1	1.2	1.5	-0.8	1.4
Stomach or abdominal pain in last month	1.1	1.3	3.3	-1.6	-0.6	-0.7	-0.5	-1.0	-1.8
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.4	-1.1	0.8	-1.9	-1.4	-0.3	-0.8
Number of full sisters	1.1	1.4	6.1	0.9	-0.5	0.8	0.3	2.5	-0.6
Supplements: Vitamin C	1.1	1.3	2.8	1.7	0.2	0.6	1.3	-0.9	1.3
Mood swings	1.1	1.9	8.0	-0.3	0.1	-2.8	-1.0	-0.8	-1.3
Osteoporosis (self-reported)	1.1	1.3	2.2	-0.6	-0.6	-1.5	-1.2	-1.5	-1.1
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.6	-0.4	0.8	-1.9	-1.1	-1.3	-0.8
Illnesses of father: High blood pressure	1.1	1.4	3.6	-1.9	-1.6	-0.4	-0.8	-0.2	-1.2
Supplements: Calcium	1.1	1.2	3.7	0.7	1.0	-1.2	0.2	-0.7	1.9
Neuroticism (Nagel 2018)	1.0	2.3	3.5	-1.3	1.6	-1.9	-1.7	-1.2	-1.2
Reaction Time	1.0	1.9	6.2	-1.1	-2.5	-0.6	-0.7	-1.5	-0.6
Breast Cancer	1.0	2.3	7.8	0.2	-2.8	1.5	0.6	1.8	0.2
Medication for hormone replacement therapy	1.0	1.1	3.2	1.0	-0.3	0.9	1.1	1.8	-0.5
Impedance of leg (right)	1.0	4.7	15.9	-1.3	-1.2	-2.2	-4.0	-1.6	-1.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	1.9	-1.2	-1.1	1.0	-1.4	-0.3	-0.8
Pain all over the body in last month	1.0	1.0	3.9	-1.0	0.8	-0.2	0.7	-2.0	-0.3
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.8	-1.4	-2.4	1.4	-1.1	-0.4	-0.8
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.8	0.7	-2.2	1.3	1.0	0.4	0.4
Body fat percentage	1.0	3.9	16.2	-1.3	-4.0	-0.1	-1.8	-0.8	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.9	0.9	2.2	0.6	0.7	0.4	0.5
Leg fat mass (right)	1.0	3.7	14.4	0.2	-3.8	1.7	-0.0	0.4	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	3.1	-0.5	1.4	0.2	-0.3	0.8	-1.8
Unable to work because of sickness or disability	1.0	1.3	3.8	1.1	-0.1	0.7	2.0	1.4	0.2
Commuting to job workplace: Cycle	1.0	1.2	2.2	-0.8	-0.6	-1.5	-1.2	-0.6	-1.4
Vascular/heart problems diagnosed by doctor	1.0	2.6	7.1	1.3	2.7	1.4	1.9	0.0	1.0
Leg fat mass (left)	1.0	4.0	14.7	0.5	-3.8	1.8	0.3	0.6	2.3
Alzheimer’s Disease (in mother)	0.9	1.0	4.0	0.2	-0.5	-2.0	-1.3	-0.4	0.1
Trunk fat percentage	0.9	3.6	14.5	-0.3	-3.8	0.6	-1.3	-0.6	2.2
Average weekly fortified wine intake	0.9	1.1	3.0	0.8	1.7	0.2	0.9	1.4	-0.3
Hayfever, allergic rhinitis or eczema	0.9	2.1	8.1	0.8	2.9	0.8	1.6	-0.1	0.6
Supplements: Glucosamine	0.9	1.2	2.6	1.1	1.5	-0.1	1.2	1.6	-0.3
Chronic bronchitis/emphysema (father)	0.9	1.0	1.9	-0.1	1.3	0.3	0.7	1.4	-1.4
Impedance of leg (left)	0.9	4.2	12.9	-0.9	-1.7	-2.3	-3.6	-1.1	-1.4
Past tobacco smoking	0.9	1.6	5.9	-1.1	-2.4	-0.5	-1.2	-0.9	-0.2
Allergy	0.9	2.2	5.5	-1.0	-1.1	-2.3	-2.1	-0.7	-0.5
Father’s age at death	0.9	1.2	2.5	1.1	0.9	1.0	1.0	1.0	1.6
Medication: Cholesterol lowering	0.9	1.4	3.8	-1.2	-1.9	0.8	-0.7	-1.5	-0.3
Pulse wave Arterial Stiffness index	0.9	1.0	2.6	1.0	1.6	0.5	0.7	1.3	0.0
Breastfed as a baby	0.9	1.1	3.6	-1.0	-1.0	-0.9	-0.5	0.1	-1.9
Blood clot in the leg (DVT)	0.9	1.2	2.4	0.3	-1.5	1.1	0.9	0.9	1.2
Number of full brothers	0.9	1.2	3.9	-1.5	-2.0	0.8	-0.4	-0.2	-0.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.8	0.9	1.7	0.9	0.8	0.8	0.6
Average weekly red wine intake	0.9	1.3	2.7	1.4	0.9	-0.6	1.6	1.4	0.6
Long-standing illness, disability or infirmity	0.9	1.3	3.3	-0.4	-1.8	1.6	0.7	-0.2	-1.2
Friendships satisfaction	0.9	1.1	2.6	-1.1	-0.4	-1.6	0.1	-0.4	-1.6
Arm fat mass (left)	0.9	3.5	7.9	0.7	-2.8	2.1	0.9	0.5	2.7
Number of self-reported non-cancer illnesses	0.9	1.6	7.3	-1.1	-2.7	-0.3	-0.2	-0.2	-0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.4	0.6	0.9	-0.6	1.1	2.1	0.2
Average weekly beer plus cider intake	0.9	1.3	3.0	0.7	-1.1	1.6	0.9	0.2	1.7
Alzheimer’s Disease (including proxy)	0.8	1.1	5.3	-0.0	-0.8	-2.3	-0.7	-0.6	0.1
Ulcerative Colitis	0.8	1.2	3.3	-0.9	1.2	-1.2	-0.5	-0.2	-1.8
BMI	0.8	4.4	21.2	-2.2	-4.6	0.4	-0.4	-0.0	-0.1
Allergy or Eczema	0.8	2.1	9.1	0.4	3.0	0.7	0.9	-0.8	1.3
Diabetes (father)	0.8	1.0	4.6	0.4	-2.1	0.8	0.0	-0.7	0.4
High blood pressure	0.8	2.1	6.0	-1.4	-2.4	-1.2	-1.5	0.2	-1.2
Medication: Levothyroxine sodium	0.8	1.3	3.6	-1.0	-1.9	0.9	-1.2	-1.1	-0.2
Had menopause	0.8	1.0	1.9	1.1	0.7	1.0	0.7	1.4	1.0
Arm fat percentage (right)	0.8	3.2	8.4	-2.4	-2.9	-0.1	-1.9	-1.2	0.5
Arm fat mass (right)	0.8	3.2	7.5	0.5	-2.7	2.2	0.8	0.5	2.4
Medication: Amlodipine	0.8	1.1	3.5	-0.7	-1.3	0.1	-0.9	-0.1	-1.9
Birth weight	0.8	1.7	6.1	-0.6	0.8	2.5	0.5	0.8	-1.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.3	-1.2	-1.0	-0.9	-0.9	0.2	-1.2
Health satisfaction	0.8	1.0	5.0	0.9	0.0	-0.3	2.2	0.2	-0.1
Had major operations	0.8	0.9	3.3	-0.0	-0.1	1.8	1.2	-0.6	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.4	-1.1	-1.1	-1.2	-0.8	0.0	-1.0
Arm fat percentage (left)	0.8	3.2	8.9	-2.2	-3.0	-0.1	-1.9	-1.2	0.7
Qualifications: nursing, teaching	0.8	1.3	3.3	1.8	0.6	0.5	1.3	-0.5	1.5
Back pain experienced in last month	0.8	1.2	4.9	-0.2	2.2	-1.4	-0.3	-0.4	-0.5
Commuting to job workplace: Public transport	0.8	0.9	2.7	-0.8	-1.1	0.1	-0.6	-1.6	0.8
High cholesterol (Self-reported)	0.8	1.3	6.2	-0.1	-2.5	0.2	1.1	0.7	-0.1
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.1	0.9	1.4	-0.6	1.2	0.0	0.7
Fasting Glucose	0.7	0.9	2.4	0.5	-1.6	1.0	1.1	-0.3	0.3
Smoking Status	0.7	1.7	2.9	1.5	1.6	0.8	1.3	1.7	-0.0
Respiratory disease	0.7	1.5	5.6	0.7	-0.3	2.4	1.6	0.7	0.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	-0.8	-1.4	0.8	-0.3	-0.2	-1.3
Severe depression (siblings)	0.7	0.8	2.5	-0.3	0.0	-0.3	-1.1	1.6	-0.9
Age when periods started (menarche)	0.7	1.7	3.0	-1.4	-1.1	-0.9	-1.6	-0.9	-1.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	1.7	-1.0	-1.3	-0.2	-0.8	0.5	-1.2
Number of incorrect matches in round	0.7	1.1	3.0	-0.5	1.5	-1.1	-1.7	-0.2	-0.1
Hearing difficulty/problems with background noise	0.7	1.1	4.9	-1.2	0.0	0.3	0.1	-0.6	-2.2
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.1	-1.2	1.2	0.4	0.2	-0.9	-1.4
Time employed in main current job	0.7	0.9	2.2	-1.4	0.6	-0.4	-1.5	-0.5	-0.5
Falls in the last year	0.7	0.9	1.7	1.1	-1.0	0.2	1.3	-0.8	1.0
Illnesses of mother	0.7	0.8	2.3	-0.1	1.5	0.8	1.0	-0.8	-0.7
Pulse wave reflection index	0.7	0.9	2.8	-0.8	1.1	0.0	0.2	0.8	-1.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.2	-1.4	-0.5	-0.4	-0.5	-0.4	-1.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.8	1.1	1.7	0.1	1.2	1.2	0.4
Gout (self-reported)	0.7	0.9	2.0	0.3	1.3	1.4	0.8	-0.8	0.9
Worry too long after embarrassment	0.7	1.2	2.1	-1.0	-0.9	-1.3	-1.5	-1.1	0.4
Hypertension (Self-reported)	0.7	2.1	7.6	-1.3	-2.8	-0.9	-1.2	0.1	-1.0
Smoking status: Previous	0.7	1.0	5.5	0.0	2.3	-0.3	0.3	0.2	-0.6
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.2	1.5	1.0	-0.3	1.4	0.0	-0.4
Number of operations (self-reported)	0.7	1.1	2.6	-1.6	0.7	0.2	-0.1	-1.2	-1.4
Risk taking	0.7	1.0	3.4	1.0	0.7	0.9	1.9	0.8	-0.1
Cholesterol lowering medication	0.7	1.0	5.0	0.2	-2.2	-0.4	0.6	0.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.4	-0.0	-1.5	0.9	0.5	0.9	1.0
Impedance of whole body	0.7	3.3	11.8	-0.6	-0.6	-1.9	-3.4	-1.7	-1.0
Worry (Nagel 2018)	0.6	1.2	3.3	-0.4	1.8	-1.6	-0.6	-0.7	-0.5
Coronary Artery Disease (CAD)	0.6	0.7	1.1	-0.8	1.0	-1.0	-0.7	-0.6	-0.8
LDL Cholesterol	0.6	0.9	3.0	-0.7	0.5	-0.3	-1.3	-1.7	0.0
Rheumatoid Arthritis	0.6	0.9	1.7	-1.0	-1.1	0.5	-0.9	-1.3	0.5
Hair Pigment	0.6	16.8	90.8	0.2	9.5	-2.0	-1.9	-1.3	0.6
Supplements: Zinc	0.6	0.6	3.2	0.1	-0.0	-1.8	0.6	-0.1	-0.4
Serious illness, injury or assault to yourself	0.6	0.8	1.6	-0.1	-1.2	0.7	1.0	0.2	-1.2
Body mass index (BMI)	0.6	2.7	10.5	-2.3	-3.2	0.2	-0.8	-0.3	0.2
Had other major operations	0.6	0.7	3.1	0.5	0.5	-0.1	1.8	-0.1	0.9
Illnesses of siblings	0.6	0.9	2.2	1.1	1.5	-0.2	0.5	1.2	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.6	-1.1	1.1	-1.1	-0.2	-1.3	-0.6
Pulse rate	0.6	1.1	2.1	0.6	-0.8	-1.5	-0.7	-0.9	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.2	-0.4	1.5	0.1	0.4	0.6	-1.2
Asthma	0.6	1.1	4.5	0.4	-0.9	2.1	1.0	0.2	-0.7
Medication: Blood pressure	0.6	1.1	2.9	-1.0	-1.2	-0.6	-1.7	-0.7	-0.5
Family relationship satisfaction	0.6	0.7	2.9	-1.0	0.4	-1.7	-0.2	-0.1	-0.3
Illnesses of siblings: Diabetes	0.6	0.8	3.5	-0.7	-1.9	-0.1	0.7	-0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.5	0.8	1.9	-0.3	0.3	-1.0	0.1
Asthma (self-reported)	0.6	1.2	4.6	0.5	-0.8	2.1	1.2	0.3	-0.6
Miserableness	0.6	1.1	2.4	-1.0	0.1	-1.2	-1.5	-0.3	-1.3
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	-0.9	-0.3	-0.5	-1.0	-1.2	-0.7
Alcohol drinker status: Never	0.6	0.8	2.1	0.3	0.8	1.2	0.3	-0.3	1.4
HDL Cholesterol	0.5	0.8	2.9	0.5	1.7	0.6	-0.6	-0.0	1.0
Neuroticism (2016)	0.5	0.7	1.7	-0.2	0.3	-1.3	-0.7	-1.0	-1.1
Schizophrenia (2014)	0.5	1.1	5.5	0.7	2.3	0.6	-0.4	0.6	-0.0
Blood Eosinophil Count	0.5	4.2	10.0	3.2	-1.4	-0.5	2.9	0.7	2.0
Average weekly spirits intake	0.5	0.6	3.2	-0.1	-1.8	-0.1	-0.6	-0.2	-0.2
Sensitivity / hurt feelings	0.5	0.9	3.2	-0.7	0.1	-0.7	-1.8	-1.2	-0.3
Medication: Co-codamol	0.5	0.6	1.0	-0.5	-1.0	1.0	0.6	0.6	-0.7
Taking other prescription medications	0.5	0.7	3.4	-0.5	-1.9	0.5	-0.2	-0.5	-0.3
Nervous feelings	0.5	0.9	3.7	-0.4	0.4	-1.9	-0.9	-0.7	-0.1
Medication: Ramipril	0.5	0.6	1.0	1.0	-0.7	0.8	0.8	0.5	1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.2	1.6	1.2	1.2	1.2	1.0	0.1	1.3
Lung cancer (father)	0.5	0.6	2.8	0.7	1.7	-0.2	0.4	0.1	-0.1
Impedance of arm (left)	0.5	2.1	6.9	-0.2	0.0	-1.0	-2.6	-2.1	0.0
Exposure to tobacco smoke outside home	0.5	0.7	1.7	1.0	-0.7	0.3	0.9	1.3	0.0
Pulse wave peak to peak time	0.5	0.6	2.2	-0.0	-1.5	0.2	0.1	-1.0	0.7
Emphysema/chronic bronchitis	0.5	0.5	1.4	0.4	0.2	0.3	0.7	1.2	1.0
Chest pain or discomfort	0.5	0.7	2.8	-0.8	-1.7	0.0	0.3	-0.1	-0.9
Osteoarthritis (self-reported)	0.5	0.6	1.4	-1.2	-1.2	-0.5	-0.6	-0.5	-0.2
Smoking status: Current	0.5	0.8	1.7	1.3	0.7	0.4	0.9	1.1	0.7
Financial situation satisfaction	0.5	0.6	1.2	0.9	0.6	-0.5	1.1	0.5	0.8
Medication: Bendroflumethiazide	0.5	0.8	2.1	-0.2	-0.2	-1.4	-0.5	-1.1	-1.1
Alzheimer’s Disease (in father)	0.4	0.4	1.2	0.2	1.0	-0.4	1.1	-0.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.2	-1.2	1.1	0.1	-0.5	0.5	-1.5
Body Mass Index (BMI) (2010)	0.4	0.5	1.7	-0.6	-1.3	0.4	0.2	-0.9	-0.4
Triglycerides	0.4	0.6	3.4	0.1	-1.8	0.1	0.1	0.3	0.4
Cardiovascular Disease	0.4	1.4	6.4	-0.2	-2.5	-1.0	-0.1	0.3	-1.0
Neuroticism	0.4	0.9	1.7	-0.2	1.2	-1.3	-0.9	-0.8	-0.8
Number of treatments/medications taken	0.4	0.7	2.3	-1.0	-0.5	0.2	-1.5	-0.5	-0.4
Ever had hysterectomy (womb removed)	0.4	0.4	1.3	0.1	-1.1	0.1	-0.2	-1.0	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.1	-0.8	-1.0	-0.8	-0.7	-0.5	-0.6
High blood pressure (mother)	0.4	0.6	1.2	1.1	0.4	-0.6	0.2	0.8	1.0
Hair/balding pattern: Pattern 2	0.4	0.6	1.9	-0.1	0.5	0.3	0.4	1.4	-1.0
Impedance of arm (right)	0.4	1.9	5.8	-0.1	0.1	-1.3	-2.4	-2.0	0.1
Happiness	0.4	0.5	1.9	-0.3	0.7	-1.4	-0.2	0.7	-0.3
Length of working week for main job	0.4	0.5	0.6	-0.7	0.5	-0.8	-0.5	-0.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	3.4	-0.4	1.8	0.0	0.4	-0.1	-0.5
Loud music exposure frequency	0.4	0.4	1.3	-0.4	0.9	1.1	0.3	-0.3	0.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.3	0.4	-0.1	1.5	1.1	0.2	-0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	0.2	-0.8	0.3	0.1	-1.0	1.0
Loneliness, isolation	0.4	0.6	1.6	0.0	-0.2	-1.3	-0.9	-0.8	0.8
Ever had bowel cancer screening	0.4	0.5	3.0	-0.0	-0.0	-1.7	0.0	0.4	-0.1
Eye problems/disorders: Cataract	0.4	0.4	1.0	-0.8	-0.8	1.0	0.0	-0.4	-0.2
Medication: Aspirin	0.4	0.6	3.1	-0.2	-1.8	-0.1	0.1	0.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	4.1	-0.1	2.0	-1.0	-0.3	-0.3	0.1
Wears glasses or contact lenses	0.4	0.4	1.3	-0.4	-1.1	-0.1	-0.0	-1.1	0.2
Medication: Blood pressure	0.4	0.7	2.1	-0.3	-0.1	-1.4	-1.0	-0.0	-1.0
Ever depressed for a whole week	0.4	0.5	1.2	0.1	-0.1	1.1	1.1	0.6	-0.3
Depression (Nagel 2018)	0.3	0.5	1.3	-0.5	0.6	-1.1	-0.8	-0.4	-0.3
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.5	-1.6	0.1	0.1	-0.9	-0.2	-1.6
Ovarian Cancer	0.3	0.5	1.1	-0.7	-0.6	-0.1	-1.0	-0.9	0.1
Mean Putamen Volume	0.3	0.3	0.7	0.8	0.0	0.5	0.5	0.2	0.8
Lung FEV1/FVC ratio	0.3	1.5	5.2	-0.3	0.3	-0.4	-0.0	-1.8	2.3
Chronotype (morning person)	0.3	0.8	2.9	0.5	-1.7	0.6	0.6	-0.2	-0.9
Maternal smoking around birth	0.3	0.4	1.1	-0.4	-0.5	0.7	0.2	-0.5	1.0
Heart attack	0.3	0.4	1.2	-1.0	0.0	-0.4	-1.1	-0.2	0.1
Fluid intelligence score	0.3	0.6	2.7	-0.4	1.7	0.6	0.6	-0.3	0.1
Alcohol intake versus 10 years previously	0.3	0.4	1.1	0.5	-0.4	1.1	0.3	-0.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.4	-0.5	0.3	-0.2	-1.2	0.3	-0.2
Prospective memory result	0.3	0.4	1.9	-0.1	-0.1	-0.7	-1.4	-0.1	-0.3
Tense / ‘highly strung’	0.3	0.4	0.9	0.9	0.9	-0.9	-0.3	0.4	0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	0.4	-1.0	0.1	0.6	0.9	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	0.2	-0.9	-1.1	0.0	-0.7	0.1
Wheeze or whistling in the chest in last year	0.3	0.5	1.1	-0.8	-1.0	0.3	0.0	0.9	-0.4
Shortness of breath walking on level ground	0.3	0.3	0.8	0.2	-0.9	-0.9	0.1	-0.0	0.5
Eye problems/disorders: None of the above	0.3	0.4	0.8	-0.4	0.9	-0.9	-0.5	0.2	-0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	0.2	0.4	0.4	-0.6	0.1	1.1
Medication: Ibuprofen	0.3	0.4	1.7	-0.3	0.5	-0.3	-1.3	0.4	-0.3
Medication: Allopurinol	0.3	0.3	0.7	0.2	0.7	0.9	0.2	-0.5	0.7
Medication: Seretide 50 evohaler	0.3	0.3	0.9	0.6	-0.5	0.5	1.0	0.1	0.3
Suffer from ‘nerves’	0.3	0.4	0.8	0.0	0.9	-0.8	0.5	-0.7	0.5
Commuting to job workplace: Walk	0.3	0.3	1.6	-0.5	-1.3	0.3	-0.1	-0.2	-0.4
Medication for cholesterol	0.3	0.5	1.3	-0.2	0.8	0.4	-0.1	-0.9	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.3	0.5	-1.1	-0.1	0.5	-0.3	0.6
Mother’s age at death	0.3	0.4	0.9	0.9	-0.2	0.3	-0.1	0.6	0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	-1.0	0.1	-0.5	-1.1	-0.4	0.2
Schizophrenia (2018)	0.2	0.5	1.9	0.2	0.9	0.1	-1.4	-0.3	-0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	-0.7	-0.7	-0.3	-0.3	-0.6	-0.2
Current tobacco smoking	0.2	0.3	0.7	0.6	0.8	-0.1	0.3	0.6	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.6	-0.4	-0.8	0.2	-0.7	0.3	-0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.5	0.3	-0.4	-0.5	-0.5	-0.6
Mouth/teeth dental problems	0.2	0.3	0.9	-0.4	0.0	-0.5	-0.9	0.4	-0.5
Noisy workplace	0.2	0.3	0.5	-0.5	-0.4	0.6	-0.3	-0.7	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	-0.1	-1.0	0.5	0.9	-0.4	-0.1
Depression (self-reported)	0.2	0.2	0.5	0.4	0.0	0.0	0.7	0.6	0.3
Pulse rate, automated reading	0.2	0.6	2.0	0.3	-1.4	-0.6	-1.0	-0.2	0.2
Leg pain on walking	0.2	0.2	0.5	-0.3	-0.0	-0.7	0.1	0.5	-0.6
Medication: Aspirin	0.2	0.3	1.2	-0.4	-1.1	-0.3	-0.4	0.3	0.0
Average weekly champagne plus white wine intake	0.2	0.2	0.8	0.1	0.7	-0.2	0.0	-0.9	-0.0
Medication: Atorvastatin	0.2	0.3	1.1	-0.1	-0.5	0.3	-0.2	1.1	-0.3
Diastolic blood pressure, automated reading	0.2	0.5	2.0	0.2	0.2	-0.2	-0.6	1.4	0.8
Myopia	0.2	0.3	1.1	0.3	-1.0	-0.3	0.2	0.1	0.5
Age at First Birth	0.1	0.2	0.8	-0.1	0.4	-0.3	-0.9	0.5	0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.7	-0.3	0.0	-0.8	-0.2	0.1	-0.6
Townsend deprivation index at recruitment	0.1	0.1	0.4	0.0	0.3	-0.6	0.3	-0.1	0.2
Qualifications: None of the above	0.1	0.2	0.6	-0.8	-0.5	-0.3	-0.4	0.0	0.2
High blood pressure (siblings)	0.1	0.1	0.2	-0.1	-0.4	-0.2	-0.4	-0.4	0.1
Age at first live birth	0.1	0.2	0.3	0.1	0.3	-0.5	-0.6	0.3	-0.4
Guilty feelings	0.1	0.2	0.7	0.3	-0.8	-0.2	0.2	-0.5	0.5
Age started oral contraceptive pill	0.1	0.1	0.4	-0.4	0.0	0.1	-0.2	-0.7	-0.2
Basal cell carcinoma (self-reported)	0.1	0.2	0.8	0.1	0.1	-0.9	0.3	-0.1	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.4	0.9	1.0	0.9	0.3	0.3	0.0	0.7

Hub : Genes

ZCCHC24

Models

Trait associations