Best TWAS P=4.02e-08 · Best GWAS P=1.45e-07 conditioned to 0.806
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | INPP5E | 0.13 | 0.12 | lasso | 2 | 0.10 | 3.5e-05 | 5.1 | -5.1 | 2.7e-07 | -0.96 | 0.01 | 0.96 | FALSE |
| 2 | GTEx | Pituitary | INPP5E | 0.21 | 0.24 | lasso | 3 | 0.14 | 1.8e-04 | 5.3 | 5.2 | 1.6e-07 | 0.99 | 0.01 | 0.95 | FALSE |
| 3 | GTEx | Stomach | SEC16A | 0.15 | 0.09 | lasso | 4 | 0.10 | 1.8e-05 | 5.2 | -5.5 | 4.0e-08 | -0.94 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Whole Blood | SEC16A | 0.07 | 0.05 | lasso | 5 | 0.04 | 1.3e-04 | 5.1 | -5.1 | 2.8e-07 | -0.98 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | INPP5E | 0.07 | 0.04 | blup | 54 | 0.07 | 6.0e-05 | 5.1 | -5.1 | 3.0e-07 | -0.89 | 0.01 | 0.95 | FALSE |