Best TWAS P=7.93e-09 · Best GWAS P=2.06e-10 conditioned to 6.53e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | ADCY3 | 0.25 | 0.23 | enet | 10 | 0.12 | 9.2e-05 | -4.8 | 5.8 | 7.9e-09 | 0.38 | 0.68 | 0.16 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | RP11-443B20.1 | 0.13 | 0.13 | enet | 9 | 0.05 | 9.2e-03 | -4.8 | 5.2 | 1.6e-07 | 0.38 | 0.33 | 0.11 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | ADCY3 | 0.17 | 0.26 | enet | 32 | 0.26 | 6.8e-33 | -4.6 | 5.4 | 6.2e-08 | 0.37 | 0.91 | 0.09 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADCY3 | 0.03 | 0.02 | blup | 81 | 0.02 | 7.1e-04 | -4.6 | 5.3 | 1.4e-07 | 0.34 | 0.06 | 0.88 | FALSE |