Hub : Genes

ADCY3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1560 0.0370 3.4e-15 0.119 0.142 0.134 0.140 0.145 2.4e-14 6.0e-17 5.2e-16 9.9e-17 3.2e-17
2 GTEx Adipose Subcutaneous 0.0650 0.0260 6.3e-04 0.039 NA 0.007 NA 0.012 3.8e-04 NA 7.7e-02 NA 3.1e-02
3 GTEx Artery Tibial 0.2104 0.0514 2.2e-09 0.136 NA 0.138 NA 0.154 8.8e-11 NA 5.7e-11 NA 4.3e-12
4 GTEx Cells EBV-transformed lymphocytes 0.2500 0.0800 2.0e-05 0.228 NA 0.121 NA 0.008 5.5e-08 NA 9.2e-05 NA 1.7e-01
5 GTEx Esophagus Mucosa 0.0560 0.0250 4.6e-03 0.054 NA 0.014 NA 0.026 1.8e-04 NA 3.6e-02 NA 6.8e-03
6 GTEx Nerve Tibial 0.0873 0.0384 3.6e-04 0.047 NA 0.032 NA 0.018 3.1e-04 NA 2.3e-03 NA 1.7e-02
7 GTEx Whole Blood 0.2340 0.0460 0.0e+00 0.237 NA 0.271 NA 0.200 1.1e-21 NA 5.5e-25 NA 3.5e-18
8 ROSMAP Brain Pre-frontal Cortex 0.1660 0.0326 0.0e+00 0.260 0.222 0.257 0.251 0.252 2.7e-33 5.4e-28 6.8e-33 5.6e-32 3.3e-32
9 YFS Blood 0.0714 0.0245 1.1e-07 0.022 0.024 0.035 0.043 0.017 6.7e-08 2.5e-08 1.4e-11 7.3e-14 1.8e-06
10 TCGA Breast Invasive Carcinoma 0.0531 0.0229 2.2e-06 0.030 0.031 0.030 NA 0.021 6.4e-07 5.0e-07 7.6e-07 NA 2.8e-05
11 TCGA Glioblastoma Multiforme 0.3610 0.1490 3.3e-03 0.145 0.111 0.131 NA 0.114 3.6e-05 3.0e-04 9.0e-05 NA 2.5e-04
12 TCGA Kidney Renal Clear Cell Carcinoma 0.0840 0.0470 9.4e-03 0.027 0.013 0.032 NA 0.022 4.5e-04 1.1e-02 1.5e-04 NA 1.3e-03
13 TCGA Brain Lower Grade Glioma 0.0282 0.0149 5.5e-04 0.017 0.025 0.010 NA 0.014 3.9e-03 7.1e-04 2.1e-02 NA 8.3e-03
14 TCGA Lung Squamous Cell Carcinoma 0.0575 0.0324 3.7e-03 0.007 0.018 0.023 NA 0.014 5.2e-02 3.2e-03 1.0e-03 NA 7.8e-03
15 TCGA Prostate Adenocarcinoma 0.0852 0.0402 2.6e-03 0.020 0.019 0.042 NA 0.034 3.4e-03 4.0e-03 3.2e-05 NA 1.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bipolar Disorder (2018) 0.8 1.3 4.7 -1.5 0.1 1.4 0.7 -1.9 -0.6 1.3 -0.7 0.1 -0.4 2.2 0.7 0.5 -0.4 1.7
Bipolar Disorder or Schizophrenia 0.1 0.3 1.3 -0.5 0.5 0.6 0.2 0.0 -0.0 0.6 -0.0 0.2 0.4 1.1 -0.4 -0.0 0.1 1.1
Depressed Affect (Nagel 2018) 1.4 3.0 7.1 -1.6 2.6 1.8 -2.2 2.4 -2.1 1.8 -2.2 0.6 0.1 -1.0 -0.3 -2.7 0.3 0.4
Depression (Nagel 2018) 1.6 2.5 6.6 -1.8 1.8 0.7 -1.2 2.6 -1.5 1.6 -1.9 -0.1 1.3 -0.2 0.9 -2.0 2.0 1.8
Intelligence (Savage-Jansen 2018) 2.0 6.3 17.0 -4.1 2.8 3.0 -2.5 0.9 -3.6 3.4 -3.6 -1.6 -1.6 -0.4 0.4 -3.0 -0.3 1.2
Neuroticism (Nagel 2018) 0.7 1.7 6.8 -0.7 2.0 0.5 -1.4 2.6 -0.9 1.0 -1.3 1.5 0.7 -0.6 -0.7 -2.1 0.6 0.4
Schizophrenia (2018) 0.2 0.4 2.5 0.6 0.5 -0.4 -0.3 1.6 0.4 -0.3 0.5 0.2 0.9 -0.3 -1.1 -0.4 0.5 0.1
Schizophrenia vs Biploar Disorder 0.4 0.5 1.6 1.2 0.2 -0.5 -0.7 1.1 0.0 -0.6 0.1 -0.9 0.4 -0.8 -0.9 -0.4 0.5 -0.9
Worry (Nagel 2018) 0.9 1.9 5.1 1.9 -0.6 -2.2 1.2 1.3 2.0 -1.6 1.6 2.1 0.8 0.0 -1.1 0.8 -0.1 -0.6
Alzheimer’s Disease (in mother) 0.2 0.3 0.9 -0.9 0.2 0.2 0.1 0.4 -0.4 0.8 -0.7 0.4 -0.1 -0.4 -0.6 -0.7 0.1 0.6
Alzheimer’s Disease (in father) 1.7 1.8 6.6 0.3 0.0 -0.2 -1.4 2.2 -0.4 0.1 -0.4 0.0 -1.2 -2.6 -2.4 -1.0 -1.4 -1.9
Alzheimer’s Disease (including proxy) 0.3 0.5 1.5 -0.8 0.2 -0.5 -0.4 1.1 -0.5 0.6 -0.6 -0.6 -0.3 -1.2 -0.9 -0.9 -0.0 -0.5
Crohns Disease (2017) 10.5 22.9 55.4 -7.4 4.3 5.7 -4.4 -1.2 -6.7 5.9 -5.8 -6.5 -5.3 -1.3 -0.2 -4.4 -3.2 -0.6
Irritable Bowel Disease (IBD) 9.8 23.4 52.4 -7.2 4.5 5.6 -4.7 -2.0 -6.5 6.0 -5.9 -6.7 -5.5 -1.1 -0.3 -4.4 -3.2 -1.4
Ulcerative Colitis (UC) 4.5 8.4 16.0 -4.0 3.1 3.4 -3.1 -1.5 -3.7 3.7 -3.8 -3.4 -3.3 -0.5 -0.3 -2.8 -1.8 -1.2
Major Depression (MDD) 1.7 2.1 6.3 -1.1 1.1 1.6 -1.4 -1.2 -1.2 1.4 -1.0 0.0 -2.4 -1.4 -0.9 -0.9 -2.5 -1.4
Reaction Time 4.5 8.6 23.3 4.8 -3.9 -3.0 2.9 -1.4 4.0 -3.8 4.2 2.4 1.7 -0.1 -1.0 3.2 0.1 -1.5
Verbal and Numeric Reasoning (VNR) 3.2 7.7 19.1 -4.4 2.9 3.7 -2.8 1.4 -3.9 3.7 -3.8 -0.9 -2.6 -1.0 -0.9 -3.2 -1.6 1.0
Breast Cancer 10.0 24.1 48.6 -6.0 6.3 6.7 -6.0 0.8 -7.0 6.6 -6.6 -3.2 -3.8 -2.3 -1.0 -5.8 -1.5 0.4
Ovarian Cancer 1.5 2.0 4.7 0.3 -0.9 -0.9 1.4 1.8 0.9 -1.0 0.8 1.7 2.1 2.1 0.9 1.0 1.7 2.2
Prostate Cancer 0.9 1.3 3.2 -1.0 0.6 1.4 -0.7 -1.4 -1.0 1.2 -1.2 -1.3 -1.7 -0.8 -0.9 -0.2 -1.8 -0.4
Age at First Birth 0.4 0.5 1.8 0.5 0.0 -0.2 -0.2 1.4 0.4 -0.3 0.4 1.1 -0.2 -1.3 -1.2 -0.0 -1.1 -0.2
Bipolar Disorder (2011) 0.5 0.5 2.6 -0.3 -0.6 0.0 0.9 0.2 0.5 -0.5 0.7 -0.4 0.9 1.0 0.2 0.8 0.2 1.6
Body Mass Index (BMI) (2010) 10.8 14.8 27.9 -5.2 4.6 4.4 -4.4 1.2 -5.3 5.0 -5.1 -3.2 -3.2 -2.5 -1.8 -4.7 -1.3 -0.0
Coronary Artery Disease (CAD) 1.0 1.2 4.8 0.2 0.1 -0.4 -0.4 -1.3 0.4 -0.1 0.7 0.1 -1.9 -1.2 -0.9 0.4 -2.1 -2.2
Crohns Disease (2012) 4.5 7.2 25.4 -4.4 1.7 3.0 -2.0 -1.0 -3.9 2.9 -3.3 -5.0 -2.5 0.1 0.0 -2.1 -1.1 0.0
Mean Putamen Volume 0.1 0.2 0.6 0.1 -0.2 0.1 0.3 -0.1 0.2 -0.4 0.2 0.7 0.5 0.6 0.6 0.4 0.2 0.2
Fasting Glucose 1.3 1.5 7.6 0.5 0.6 0.1 -1.1 1.3 -0.9 0.7 -1.2 -0.0 -0.8 -2.8 -1.2 -0.9 -1.0 -2.2
HbA1C 0.8 0.9 5.2 -1.8 0.2 1.0 -0.1 -0.3 -1.2 0.7 -0.7 -2.3 -0.4 -0.1 0.8 0.0 -0.1 0.0
HDL Cholesterol 2.3 3.8 10.4 3.2 -1.6 -2.9 1.5 0.1 2.4 -2.4 2.1 1.2 2.4 0.5 1.0 1.1 2.8 0.0
LDL Cholesterol 0.1 0.2 0.6 -0.4 0.4 -0.2 -0.4 0.0 -0.5 0.3 -0.0 -0.4 -0.3 -0.8 0.1 -0.2 0.5 -0.6
Lupus 1.2 1.8 6.5 0.6 -0.5 -1.6 1.0 1.4 1.0 -1.0 1.0 0.5 2.1 1.3 1.2 0.7 2.5 1.8
Neuroticism (2016) 0.5 0.7 1.6 1.1 -0.4 -0.9 0.9 -0.8 1.1 -1.1 0.8 1.3 0.5 0.9 0.7 0.6 -0.2 0.0
Primary Biliary Cirrhosis 2.6 3.8 8.5 -2.9 2.0 2.2 -1.7 -0.5 -2.8 2.5 -2.6 -2.0 -1.5 1.2 1.4 -2.1 -0.4 1.1
Rheumatoid Arthritis 1.0 1.4 3.0 -1.0 1.0 0.9 -1.6 -0.1 -1.5 1.1 -1.2 -1.7 -1.0 -1.7 -0.5 -1.2 -0.4 -1.2
Schizophrenia (2014) 0.1 0.1 0.8 0.2 0.3 -0.0 0.1 0.5 0.4 -0.0 0.4 0.2 0.4 0.5 -0.9 -0.1 -0.1 0.1
Triglycerides 0.3 0.5 1.3 -0.4 -0.3 -0.4 1.1 -0.4 0.3 -0.3 0.2 -0.5 0.7 0.9 1.1 1.1 0.7 0.9
Type 2 Diabetes (T2D) (2012) 0.7 0.8 4.8 0.2 -0.3 0.3 0.8 1.1 0.1 -0.3 0.2 2.2 1.6 0.5 -0.4 0.2 1.3 0.8
Ulcerative Colitis 3.9 5.7 10.1 -3.1 2.6 2.6 -2.9 -0.1 -3.1 3.1 -3.2 -2.3 -2.4 -1.2 -1.0 -2.7 -1.1 -1.4
Blood Eosinophil Count 1.2 9.5 22.2 -4.7 3.3 4.2 -2.7 -0.4 -4.2 4.5 -4.2 -2.3 -3.2 0.6 0.3 -3.0 -1.8 1.2
Blood Platelet Count 0.4 4.1 8.5 -0.5 2.4 1.7 -2.9 1.4 -2.1 2.0 -2.0 1.6 -2.2 -2.4 -2.3 -2.7 -1.8 -0.2
Blood Red Count 0.4 4.1 18.1 -2.2 -0.1 1.4 2.2 -2.5 -0.3 0.5 -0.7 0.2 0.9 4.3 3.5 1.6 0.6 2.8
Blood White Count 1.3 9.4 23.8 -4.9 3.2 4.2 -1.9 -2.2 -3.9 3.9 -3.9 -3.9 -2.2 2.1 0.9 -2.2 -0.9 1.9
Heel T-Score 1.0 7.8 27.2 1.2 2.9 1.0 -4.4 3.4 -1.6 1.9 -2.1 2.0 -0.5 -5.2 -3.7 -3.9 0.1 -2.3
BMI 30.6 177.4 346.0 -18.4 16.2 16.7 -15.2 5.2 -18.6 18.0 -18.0 -10.5 -9.4 -5.3 -3.9 -16.3 -3.4 3.3
Height 15.5 298.2 561.7 17.6 -20.7 -19.2 23.7 -8.4 22.2 -20.7 22.6 10.6 14.8 14.7 14.1 20.8 9.1 6.3
Waist Hip Ratio (WHR) 3.8 17.2 56.2 0.1 -3.2 -2.2 5.3 -3.0 2.7 -2.3 2.6 2.5 4.4 7.5 7.0 4.1 4.5 4.3
Systolic Blood Pressure 9.0 45.0 85.4 5.6 -7.7 -6.6 9.2 -3.7 8.1 -7.3 7.2 5.0 6.1 8.0 6.7 8.4 3.7 4.1
Smoking Status 3.3 7.9 14.8 -3.3 3.6 3.2 -3.2 0.5 -3.8 3.7 -3.4 -3.6 -2.1 -1.3 -1.2 -3.6 -0.6 -0.1
Allergy or Eczema 0.8 2.1 7.3 -1.3 1.7 1.0 -1.2 2.7 -1.5 0.9 -1.1 -0.8 1.2 -0.2 -0.9 -2.1 1.7 1.4
Cardiovascular Disease 2.5 8.3 32.4 -1.2 -1.3 -0.5 2.9 -0.8 1.1 -0.5 0.3 1.1 3.0 5.7 5.1 1.7 2.9 5.6
Hypothyroidism (self reported) 1.6 3.6 11.4 -2.6 1.7 2.5 -1.6 -0.6 -2.5 2.2 -2.4 -3.4 -1.8 0.1 0.2 -1.2 -1.5 0.2
Respiratory disease 0.6 1.2 2.3 -0.9 1.5 1.1 -1.4 1.2 -1.0 1.3 -1.3 1.0 -0.8 -1.0 -1.3 -1.4 -0.5 -0.1
Type 2 Diabetes (T2D) (2018) 1.2 2.2 7.4 -2.7 0.8 1.9 -0.8 2.2 -1.6 1.6 -1.8 -0.1 0.6 0.5 0.5 -1.4 0.3 2.1
Lung FEV1/FVC ratio 5.3 26.8 55.5 -6.7 6.0 6.6 -5.7 -0.4 -7.5 7.2 -7.0 -4.3 -5.0 -1.4 -1.9 -5.8 -2.4 0.2
Lung FVC 2.0 10.3 16.9 3.8 -2.8 -2.8 3.4 -1.0 3.6 -3.5 3.6 2.8 4.1 3.9 2.1 3.0 3.8 2.6
Neuroticism 1.0 2.5 9.7 -1.8 2.1 1.0 -1.6 3.1 -1.6 1.6 -1.9 0.7 0.3 0.4 0.3 -2.5 0.4 1.2
Chronotype (morning person) 4.2 9.7 19.1 3.7 -3.9 -3.5 4.0 -2.3 4.2 -4.0 4.0 1.8 2.2 2.2 0.8 4.4 0.7 -0.2
Hair Pigment 0.5 15.4 42.0 -6.5 5.0 4.0 -4.1 -0.7 -5.0 5.2 -4.7 -1.9 -4.5 -1.1 0.8 -4.8 -2.6 -0.2
Tanning 1.8 21.6 46.1 5.3 -5.7 -4.2 5.6 -6.6 5.8 -5.4 6.4 1.6 -0.1 1.2 1.4 6.8 -2.0 -3.2
Hand grip strength (left) 12.6 33.3 61.5 6.7 -6.1 -7.3 7.0 -0.0 7.6 -7.8 7.8 2.7 6.1 3.5 4.0 6.4 4.2 1.7
Number of treatments/medications taken 1.4 2.5 9.5 -1.4 0.4 -0.5 0.2 -0.4 -0.5 0.7 -0.8 -2.2 1.8 2.3 2.5 -0.5 3.1 2.1
Average weekly spirits intake 0.9 1.1 7.8 -1.5 -0.6 -0.2 -0.3 -0.4 -0.4 -0.1 0.5 -2.8 -1.2 -0.8 0.1 0.5 -1.5 -0.9
Sensitivity / hurt feelings 2.3 3.9 6.8 -2.1 2.0 2.0 -2.2 1.6 -2.2 2.2 -2.2 -0.5 -1.8 -1.9 -2.6 -2.4 -1.8 -0.5
Frequency of depressed mood in last 2 weeks 2.0 2.9 6.8 -2.6 1.9 1.6 -0.9 1.3 -2.0 2.1 -2.5 -0.2 0.6 0.6 1.7 -2.0 1.4 1.9
Hearing difficulty/problems: Yes 2.3 3.5 8.6 -2.4 2.9 1.8 -1.8 1.6 -2.5 2.6 -2.7 -1.0 -0.3 0.0 -0.7 -2.3 0.7 1.0
Relative age of first facial hair 1.2 2.4 7.0 -0.9 2.2 1.1 -2.6 0.7 -2.2 1.7 -2.2 -0.8 -0.9 -0.6 0.7 -2.6 0.6 -0.4
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 4.1 -0.4 -0.0 -0.8 0.4 -1.9 0.2 -0.0 0.1 -2.0 0.2 1.3 1.7 0.4 1.0 0.7
Ever used hormone-replacement therapy (HRT) 1.1 1.4 3.6 1.0 -1.0 -1.3 1.2 -0.0 1.1 -1.3 1.5 0.5 1.4 1.2 1.9 1.0 1.4 0.8
Ever had hysterectomy (womb removed) 0.4 0.4 2.2 0.3 -0.3 -0.2 0.5 -0.7 0.5 -0.4 0.5 0.2 0.7 1.2 1.5 0.4 0.8 0.4
Systolic blood pressure, automated reading 4.5 13.2 32.8 1.4 -3.3 -2.4 5.0 -1.2 3.5 -3.0 2.8 3.1 4.2 5.7 4.0 3.8 3.2 4.7
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 7.6 -1.4 0.9 1.5 -1.4 2.8 -1.7 1.7 -1.6 0.5 0.2 -0.5 -0.8 -1.9 0.6 1.3
Angina 2.8 3.7 11.5 -2.3 1.8 1.9 -1.8 -1.7 -2.3 1.8 -1.5 -3.4 -2.6 -1.3 -0.4 -1.3 -2.0 -0.9
Medication for hormone replacement therapy 2.1 2.4 6.8 1.9 -1.0 -2.3 0.8 1.1 1.6 -1.9 1.6 -0.6 2.5 0.6 0.4 0.8 2.6 0.2
Vitamin and mineral supplements 1.6 2.2 5.6 -2.4 1.3 2.4 -1.2 0.6 -1.9 1.8 -2.1 0.5 -1.0 -0.8 -1.0 -1.3 -1.4 0.2
Supplements: Zinc 0.8 0.9 3.0 1.3 -0.5 -1.7 0.1 0.7 1.1 -0.8 1.1 1.1 -0.3 -0.8 -1.1 -0.1 -0.2 -1.1
Medication: Co-codamol 1.2 1.3 3.5 -1.4 1.4 0.9 -1.3 -1.1 -1.1 1.6 -1.2 -0.9 -1.9 -0.3 -0.9 -1.1 -0.8 0.3
Medication: Metformin 2.8 4.0 10.7 -3.3 1.6 2.9 -2.0 2.7 -2.6 2.4 -2.7 -0.3 -0.3 -0.5 -0.8 -2.0 -0.4 1.6
Diabetes (father) 1.0 1.3 3.8 1.0 -1.2 -0.9 1.1 -0.7 1.1 -1.2 0.7 -0.2 1.5 0.4 1.9 1.5 1.4 0.8
Diabetes (mother) 0.4 0.5 2.0 0.4 -0.5 -0.7 0.6 0.5 0.8 -0.4 0.3 1.4 0.5 -0.3 -1.0 0.9 0.2 0.6
Severe depression (siblings) 1.9 2.1 3.4 -1.8 1.4 1.6 -1.3 -0.0 -1.7 1.8 -1.7 -1.9 -1.6 -1.3 -1.4 -1.0 -1.2 -0.4
Pack years adult smoking proportion 3.0 4.6 10.8 -2.9 2.3 2.7 -2.2 0.9 -2.9 2.6 -2.5 -3.3 -1.2 -0.8 -1.0 -2.4 -0.9 0.6
Impedance of leg (right) 4.7 22.9 44.6 6.4 -5.4 -5.2 6.1 -3.0 6.7 -6.1 6.0 4.8 3.6 2.7 1.5 5.9 0.8 -0.9
Leg fat-free mass (left) 1.0 5.2 15.6 -4.0 1.4 2.1 -0.2 1.0 -2.6 2.4 -1.7 -2.7 0.1 1.7 3.2 -1.4 1.7 3.9
Trunk fat percentage 17.7 70.9 166.4 -12.9 9.9 11.3 -8.2 2.4 -11.9 11.7 -11.6 -6.4 -4.9 -0.9 -0.2 -9.9 -1.3 4.2
Hand grip strength (right) 10.4 28.4 58.2 6.1 -5.7 -6.7 6.7 0.3 6.8 -7.3 7.6 2.2 5.4 3.0 3.4 6.1 3.8 1.6
Townsend deprivation index at recruitment 0.6 0.8 3.1 -1.8 0.8 1.1 -0.6 0.6 -1.2 1.3 -1.3 -0.1 -0.1 0.6 0.2 -1.0 0.0 0.8
Current tobacco smoking 1.4 2.2 7.0 -1.9 1.6 2.0 -1.2 -0.7 -1.9 1.9 -1.6 -2.6 -1.4 -0.1 -0.2 -1.2 -1.1 -0.1
Average weekly fortified wine intake 0.5 0.6 1.5 -0.8 0.6 -0.5 -0.8 1.2 -0.6 0.6 -0.6 -0.9 -0.1 -1.0 -1.2 -0.7 0.5 -0.8
Maternal smoking around birth 0.3 0.4 1.5 -0.6 0.6 0.6 -0.4 1.2 -0.6 0.4 -0.4 0.2 0.3 0.1 0.9 -0.7 -0.1 0.8
Fed-up feelings 1.5 2.8 8.4 -1.5 2.2 1.5 -2.0 2.9 -2.1 1.8 -2.0 0.4 0.2 -0.9 -0.7 -2.5 0.8 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 4.6 -1.2 1.0 0.6 -0.6 2.2 -1.0 1.0 -1.3 0.2 1.0 -0.4 -0.1 -1.3 1.1 1.6
Relative age voice broke 1.2 1.9 5.4 -0.2 2.1 1.1 -1.8 0.5 -1.8 1.4 -2.0 0.1 0.4 -0.0 0.7 -2.3 1.9 0.1
Taking other prescription medications 0.8 1.3 4.1 -2.0 1.2 1.0 -0.9 -0.0 -1.3 1.6 -1.8 -1.3 -0.3 0.3 0.6 -1.1 0.3 1.1
Age when periods started (menarche) 7.2 17.2 37.4 6.1 -4.2 -4.6 4.2 0.1 5.3 -5.6 5.3 4.6 4.8 2.2 1.1 3.7 3.4 0.6
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 3.5 0.3 -1.2 -0.3 1.8 -0.7 0.9 -1.0 1.5 0.7 1.1 1.9 1.3 1.6 0.9 1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 4.1 -0.3 1.0 -0.2 -1.8 1.4 -0.7 0.7 -1.2 -1.4 -0.2 -2.0 -0.9 -1.9 0.0 -0.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 2.6 -0.2 -0.1 0.1 0.1 1.6 0.0 -0.1 -0.0 0.5 0.2 -0.8 -0.6 0.2 -0.6 0.1
Qualifications: CSEs or equivalent 0.9 1.2 5.0 -0.5 0.9 1.5 -0.4 -0.8 -0.5 1.0 -0.5 0.0 -0.9 -1.8 -2.2 0.2 -1.9 -0.4
Serious illness, injury or assault to yourself 0.4 0.5 1.7 -0.0 -0.6 -1.3 -0.1 -0.7 0.4 -0.2 0.5 -1.3 0.0 -0.3 1.3 0.2 0.8 -0.3
High blood pressure 3.7 10.2 39.7 -1.0 -1.6 -0.5 3.5 -0.8 1.5 -0.8 0.5 1.9 3.6 5.9 5.4 1.9 3.1 6.3
Hayfever, allergic rhinitis or eczema 0.6 1.2 5.2 -0.5 1.2 0.3 -0.9 2.3 -0.9 0.3 -0.6 -1.1 1.2 0.2 -0.9 -1.6 1.6 0.8
Multivitamins +/- minerals 2.0 2.5 6.9 2.0 -1.8 -2.6 1.4 -0.2 2.0 -2.2 2.3 -0.5 1.1 0.8 1.4 1.5 1.3 -0.1
Stomach or abdominal pain in last month 0.2 0.2 1.1 -0.2 -0.4 -0.4 0.4 1.1 0.0 -0.5 0.6 -0.1 0.3 -0.6 -0.7 0.2 0.3 0.1
Supplements: Glucosamine 0.4 0.6 2.2 -0.1 -0.3 -0.0 0.3 -0.6 -0.0 -0.2 0.5 -1.4 0.6 0.9 1.5 0.3 1.3 0.8
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 3.0 1.7 -0.8 -0.8 0.3 -1.3 1.3 -0.8 1.0 1.2 0.2 0.1 -0.5 0.9 0.1 -0.5
Medication: Atenolol 2.9 3.6 14.9 -1.8 0.8 1.3 0.0 0.6 -1.1 1.0 -1.5 -0.1 1.9 2.9 3.1 -0.9 2.5 3.9
Medication: Levothyroxine sodium 0.7 1.1 3.9 -1.3 1.0 1.3 -0.6 -0.8 -1.3 1.3 -1.4 -2.0 -1.0 0.1 0.6 -0.6 -0.7 -0.2
Sitting height 15.8 112.0 234.1 14.5 -13.3 -14.1 12.1 -2.0 15.0 -14.2 15.3 7.4 7.1 2.4 2.8 12.4 2.6 -1.8
Chronic bronchitis/emphysema (father) 0.5 0.6 3.2 0.2 -0.1 -0.1 -0.0 0.6 0.4 -0.1 0.3 1.6 -0.6 -0.7 -1.8 -0.3 -1.3 -0.6
High blood pressure (mother) 0.8 1.1 4.5 -0.2 -0.6 -0.1 1.5 -1.5 0.8 -0.2 0.1 0.2 0.6 2.1 1.0 1.2 0.5 1.7
Body mass index (BMI) 26.6 113.1 228.0 -15.1 12.7 13.6 -11.9 4.2 -15.0 14.4 -14.5 -8.6 -7.1 -3.7 -2.1 -12.7 -2.4 3.5
Impedance of leg (left) 4.6 22.1 44.2 6.4 -5.3 -5.2 5.9 -3.1 6.7 -6.0 6.1 4.6 3.3 2.4 1.1 5.9 0.7 -1.0
Leg predicted mass (left) 1.0 5.0 15.2 -3.9 1.3 2.1 -0.2 0.9 -2.5 2.3 -1.6 -2.8 0.1 1.7 3.2 -1.4 1.6 3.8
Trunk fat mass 12.3 52.9 134.6 -11.6 8.4 9.6 -6.5 2.3 -10.3 10.1 -9.8 -5.9 -3.6 0.0 1.0 -8.4 -0.1 5.0
Waist circumference 13.5 49.5 136.9 -11.7 7.9 9.2 -6.0 1.7 -9.9 9.8 -9.5 -5.9 -3.5 0.7 1.9 -7.7 -0.0 4.9
Number of incorrect matches in round 4.0 6.7 13.2 3.3 -3.3 -3.4 3.2 -0.2 3.6 -3.6 3.2 1.8 2.5 1.4 0.5 2.8 1.1 0.2
Past tobacco smoking 4.9 9.0 19.5 3.7 -4.2 -3.4 3.2 -1.6 4.1 -4.3 3.9 1.9 1.2 0.7 0.5 4.4 -0.7 -1.7
Alcohol usually taken with meals 0.8 1.3 3.7 1.1 -1.2 -1.1 1.9 -1.7 1.3 -1.2 1.5 -0.1 0.0 0.6 0.9 1.8 -0.3 -0.2
Nervous feelings 0.7 1.2 4.7 1.4 -0.4 -2.2 0.4 1.5 1.6 -1.3 1.3 0.5 0.6 -0.9 -1.3 0.3 0.1 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.5 -0.6 0.2 0.4 0.9 -0.7 -0.1 0.4 -0.4 1.2 0.6 0.8 0.7 0.1 0.9 0.9
Hearing difficulty/problems with background noise 1.2 2.0 4.7 -1.4 1.6 1.3 -0.3 2.2 -1.4 1.6 -1.9 0.3 1.2 0.6 -0.5 -1.3 1.6 2.0
Hair/balding pattern: Pattern 2 0.3 0.4 1.8 -0.2 0.3 1.1 -0.5 -1.3 -0.6 0.6 -0.3 -0.0 -0.6 0.1 0.3 0.3 -0.6 -1.0
Had menopause 0.8 1.0 3.0 0.8 -1.0 -0.8 1.1 -0.9 1.0 -0.9 0.7 0.5 1.2 1.7 1.4 0.9 1.0 0.4
Had other major operations 0.4 0.5 2.8 -0.9 0.1 0.1 -0.5 -0.1 -0.4 0.7 -0.5 -1.7 0.4 0.5 0.6 -0.5 0.9 1.1
Forced vital capacity (FVC) 15.6 60.0 96.2 8.6 -8.5 -8.4 9.8 -2.6 9.7 -9.3 9.7 5.3 8.0 7.1 6.3 8.7 6.0 3.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 2.2 -0.4 0.7 0.5 -1.0 -0.0 -0.3 0.6 -0.8 -0.5 -0.2 -1.5 -0.3 -0.9 -0.4 0.0
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 4.1 -1.7 1.6 1.8 -1.5 1.7 -1.6 1.5 -1.6 0.2 -0.7 -1.6 -0.7 -2.0 -1.1 -0.3
Qualifications: None of the above 0.1 0.2 0.8 0.5 0.7 -0.3 -0.9 -0.3 0.1 0.3 -0.1 -0.0 0.1 -0.3 -0.3 -0.8 0.6 -0.4
Financial difficulties in last 2 years 0.5 0.7 2.0 -1.1 1.0 0.8 -0.9 1.2 -1.2 0.6 -0.8 -1.4 0.3 -0.2 -0.5 -0.6 0.7 0.0
Mouth/teeth dental problems 2.8 4.4 9.5 3.0 -2.6 -2.4 2.2 -1.8 2.8 -3.0 3.1 0.1 0.3 -0.0 -0.1 2.7 -0.5 -1.5
Heart attack 0.9 1.1 6.1 0.4 -0.1 -0.3 -0.6 -1.8 -0.2 -0.2 0.5 -2.5 -1.2 -1.0 -0.3 0.0 -0.9 -1.8
Allergy 0.2 0.5 1.8 0.2 -0.9 -0.2 0.7 -1.3 0.6 -0.4 0.5 0.6 -0.1 0.5 1.4 1.0 -0.3 0.0
Pain all over the body in last month 1.4 1.5 5.7 0.5 -0.3 -0.6 1.1 0.7 0.7 -0.8 0.3 0.4 2.4 1.3 1.0 0.4 2.4 2.0
Diabetes (self-reported) 2.2 3.4 13.9 -2.7 1.4 1.9 -1.7 3.7 -2.0 1.7 -2.2 -0.6 0.9 -0.7 -0.9 -2.1 0.6 1.7
Hayfever/allergic rhinitis (self-reported) 1.7 2.2 7.4 0.1 -0.8 -1.6 1.6 2.2 1.0 -1.3 0.9 -0.6 2.7 1.4 0.4 0.5 2.3 1.8
Medication: Ramipril 2.3 2.9 11.8 -0.7 -0.8 -0.4 1.4 0.2 0.6 -0.6 0.2 -0.7 2.3 3.4 2.4 1.1 2.0 3.3
Medication: Simvastatin 1.0 1.5 4.4 -2.1 0.8 0.9 -0.7 0.6 -1.3 1.3 -1.2 -1.4 0.4 0.9 1.8 -0.9 1.0 1.9
Fluid intelligence score 3.0 6.2 13.0 -3.6 2.7 2.5 -3.1 2.4 -3.4 3.2 -3.3 -0.6 -1.8 -1.6 -0.8 -3.4 -0.5 0.5
Illnesses of siblings 1.5 2.0 4.5 2.1 -1.8 -1.4 1.1 0.3 1.6 -2.1 2.1 0.8 1.3 -0.6 -0.2 1.6 0.6 -1.7
Neuroticism score 1.6 3.3 6.8 -2.1 2.5 2.0 -1.7 2.6 -2.3 2.2 -2.3 0.3 -0.5 -0.4 -1.4 -2.6 -0.5 0.4
Weight 5.2 25.8 74.7 -8.6 5.4 6.4 -3.5 1.5 -7.0 6.9 -6.3 -4.8 -1.8 1.2 2.6 -5.3 1.1 5.3
Impedance of arm (right) 1.1 5.1 11.7 2.3 -2.9 -1.5 3.4 -1.6 2.9 -2.6 2.5 3.1 1.6 1.9 0.3 2.8 -0.2 -0.7
Arm fat percentage (right) 31.6 124.7 272.2 -16.5 13.1 14.8 -11.7 4.3 -15.9 15.1 -15.4 -8.6 -7.1 -3.0 -2.0 -13.2 -2.6 4.0
Trunk fat-free mass 2.6 14.7 33.2 1.3 -3.7 -3.4 5.1 -0.3 3.3 -3.3 4.1 -0.0 4.3 4.5 5.8 3.8 4.5 4.8
Hip circumference 11.4 49.1 114.5 -10.7 7.9 8.9 -7.2 2.8 -9.8 9.5 -9.1 -6.9 -4.6 -2.5 -0.7 -8.1 -1.6 2.7
Time employed in main current job 3.9 4.5 9.5 2.7 -2.4 -2.1 2.5 -3.1 2.8 -2.2 2.9 1.8 -0.0 0.8 1.1 2.5 -0.8 -1.4
Alcohol intake versus 10 years previously 0.2 0.3 0.8 -0.3 0.4 0.7 -0.3 -0.4 -0.5 0.4 -0.2 -0.5 -0.7 -0.4 -0.9 -0.4 -0.7 -0.4
Father’s age at death 0.3 0.4 1.5 1.0 -0.3 -0.7 0.5 -0.8 0.8 -0.7 0.3 0.2 -0.0 0.0 1.2 0.2 0.3 -0.6
Worrier / anxious feelings 1.9 3.6 7.3 2.6 -1.8 -2.7 1.9 1.1 2.5 -2.5 2.7 2.4 1.3 -0.1 -1.4 1.5 0.4 -0.9
Frequency of tiredness / lethargy in last 2 weeks 2.4 3.9 9.0 -3.0 2.2 3.0 -1.7 1.0 -2.6 2.7 -2.9 -0.4 -0.6 -0.3 -1.4 -2.1 -0.7 1.3
Falls in the last year 0.5 0.7 2.1 -1.5 0.2 0.4 0.4 -0.5 -0.5 0.6 -0.5 -0.7 -0.6 1.4 1.4 -0.2 -0.2 1.4
Hair/balding pattern: Pattern 3 0.7 1.1 3.5 1.2 -0.8 -0.8 1.5 1.1 1.3 -1.4 0.8 0.6 1.9 0.4 -0.5 0.9 0.9 0.5
Number of live births 0.3 0.4 1.0 -0.2 -0.9 -0.2 0.8 -0.6 0.5 -0.4 0.3 -0.4 -0.3 0.9 0.5 0.9 -0.5 1.0
Forced expiratory volume in 1-second (FEV1) 10.6 35.8 56.9 6.3 -6.8 -6.5 7.5 -2.4 7.2 -7.0 7.4 3.5 6.0 6.2 5.2 6.9 4.8 3.0
Pulse rate 0.9 1.6 6.6 0.4 -0.9 -1.4 0.6 2.6 0.9 -0.6 0.4 1.6 1.9 0.7 -0.4 0.4 2.2 0.9
Happiness 0.2 0.3 1.1 -0.8 0.4 0.8 -0.3 -0.5 -0.7 1.0 -0.6 -0.5 -0.4 0.2 -0.1 -0.1 0.0 0.1
Noisy workplace 0.3 0.3 0.9 1.0 -0.4 0.2 0.6 -0.7 0.6 -0.5 0.5 0.8 0.7 0.2 -0.2 0.9 -0.0 0.4
Qualifications: A levels/AS levels or equivalent 0.9 2.0 4.7 0.1 -2.2 -2.1 2.2 0.3 1.7 -1.9 1.8 -0.1 0.8 1.3 1.0 1.7 0.3 0.8
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 3.5 -0.6 1.6 0.8 -1.9 0.1 -1.3 1.2 -0.9 -1.0 -0.9 -1.8 -1.7 -1.6 -0.1 -1.6
Mouth/teeth dental problems: Dentures 4.9 8.3 20.6 -4.5 3.3 2.9 -3.3 0.8 -3.8 4.0 -4.3 -2.1 -2.1 -0.8 -0.1 -3.6 -1.1 0.9
Asthma 0.5 1.0 3.3 -1.8 1.3 1.1 -0.7 0.7 -1.1 1.4 -1.2 0.2 -1.0 -0.2 -0.4 -1.0 -0.7 1.0
Medication: Ibuprofen (e.g. Nurofen) 2.5 3.2 9.5 0.4 -1.0 -0.8 2.1 -0.0 1.1 -1.2 1.3 -0.2 2.9 2.8 1.8 1.6 3.1 2.5
Medication: Cholesterol lowering 0.6 0.9 3.7 -0.5 0.4 -0.2 -0.5 0.2 -0.6 0.3 -0.4 -1.9 1.0 0.9 1.6 -0.4 1.8 0.9
Depression (self-reported) 0.2 0.3 1.9 0.3 0.2 0.1 -0.2 -0.2 0.2 -0.0 -0.3 1.4 0.8 0.2 0.7 -0.0 0.6 0.8
Medication: Lansoprazole 0.6 0.7 3.0 -1.5 0.3 0.6 0.0 -1.1 -0.8 0.6 -0.6 -1.7 -0.3 -0.2 1.2 0.3 -0.3 -0.2
Prospective memory result 0.2 0.3 0.7 -0.0 -0.7 -0.1 0.7 -0.9 0.5 -0.4 0.5 -0.1 0.3 0.5 -0.3 0.9 -0.0 -0.6
Lung cancer (father) 0.4 0.5 1.5 0.2 -0.8 -0.8 0.4 -0.8 0.6 -0.7 1.2 -0.4 -0.3 0.1 1.0 0.7 -0.4 -0.7
Illnesses of mother 1.0 1.2 4.8 1.5 -0.2 -0.8 -0.6 1.8 0.2 -1.0 0.9 0.4 0.0 -2.2 -1.5 -0.1 -0.3 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 7.5 23.9 40.1 4.9 -5.4 -5.0 6.3 -2.4 5.8 -5.5 6.2 2.9 4.6 5.3 4.4 5.8 3.6 3.0
Pulse wave Arterial Stiffness index 0.2 0.2 1.1 -0.1 0.1 0.1 0.6 0.3 0.2 -0.0 0.5 0.3 0.1 -0.7 -0.6 0.4 -0.3 1.1
Impedance of arm (left) 1.0 4.9 11.0 2.2 -2.7 -1.7 3.3 -2.1 2.8 -2.5 2.5 2.4 1.4 2.5 1.2 2.6 -0.1 -0.3
Arm fat mass (right) 19.8 81.5 196.0 -14.0 10.3 11.9 -8.8 3.6 -12.9 12.3 -12.3 -7.7 -5.1 -1.2 -0.1 -10.4 -1.1 5.0
Trunk predicted mass 2.6 14.8 33.9 1.2 -3.6 -3.3 5.1 -0.2 3.3 -3.3 4.1 -0.1 4.4 4.5 5.8 3.8 4.5 4.9
Standing height 15.7 156.2 292.4 12.5 -14.7 -14.2 17.1 -5.3 15.9 -14.9 16.5 7.1 11.2 10.6 10.5 14.9 7.6 4.7
Length of working week for main job 0.2 0.2 1.2 -0.3 -0.5 0.2 0.2 0.7 -0.2 -0.3 0.2 -0.1 0.8 1.1 0.8 0.1 0.3 0.4
Exposure to tobacco smoke at home 0.4 0.5 2.4 0.5 -0.8 -0.1 0.7 -1.6 0.6 -0.3 0.7 0.4 -0.5 0.1 -0.0 0.9 -0.7 -0.7
Breastfed as a baby 1.1 1.4 2.6 1.1 -1.4 -0.9 1.4 -1.1 1.6 -1.3 1.6 1.3 0.1 -0.5 -0.3 1.3 -0.7 -1.5
Tense / ‘highly strung’ 0.5 0.8 2.4 1.0 -0.6 -1.0 1.6 0.1 1.3 -0.9 1.0 1.4 0.2 0.8 -0.8 0.8 -0.5 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 6.7 -2.3 2.5 1.5 -1.9 2.0 -1.9 2.0 -2.2 1.1 -0.3 -0.4 -1.0 -2.6 -0.0 0.7
Hair/balding pattern: Pattern 4 0.6 1.4 3.5 -1.9 1.2 1.5 -1.1 0.2 -1.4 1.6 -1.6 -1.2 -0.9 -0.4 -0.9 -1.0 -1.0 0.3
Birth weight of first child 1.5 2.7 5.5 1.6 -1.4 -1.2 1.9 0.3 1.7 -1.6 1.7 1.9 2.3 1.5 1.8 1.3 2.0 1.5
Peak expiratory flow (PEF) 4.6 10.7 16.5 3.1 -3.5 -4.0 4.0 -1.6 4.0 -3.7 4.1 1.6 3.1 3.6 3.3 3.6 2.9 1.4
Pulse wave reflection index 0.3 0.3 0.9 -0.5 0.7 1.0 0.1 -0.6 -0.5 0.4 -0.2 -0.5 -0.5 -0.9 -0.6 -0.2 -0.6 0.3
Ever highly irritable/argumentative for 2 days 0.2 0.2 1.2 -0.3 0.6 1.1 -0.1 -0.5 -0.8 0.4 -0.3 0.1 -0.1 0.2 0.2 -0.4 0.3 0.4
Loud music exposure frequency 0.8 0.8 3.5 1.9 -0.5 -1.2 0.9 -0.4 1.1 -1.2 1.0 0.4 1.0 0.6 -0.0 0.7 0.8 -0.1
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 3.6 -0.3 -1.8 -0.3 1.9 -0.3 0.6 -1.0 1.0 -0.8 0.1 1.2 0.3 1.7 -0.8 0.9
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.7 -1.2 1.0 1.3 -0.7 1.3 -1.2 0.8 -0.9 1.0 0.1 0.1 0.3 -1.0 -0.2 0.3
Blood clot in the leg (DVT) 1.6 2.1 6.6 -0.3 0.4 0.6 -1.1 -1.5 -0.5 0.7 -0.3 -0.5 -2.5 -2.1 -1.5 -0.6 -2.6 -2.5
Medication: Paracetamol 0.6 1.0 5.2 -0.8 0.0 0.2 0.5 -0.3 -0.5 0.6 -0.5 -1.2 1.6 1.5 0.8 -0.1 2.3 1.2
Headache pain in last month 0.2 0.3 1.2 -0.7 -0.2 0.8 0.6 0.4 -0.5 0.3 -0.5 -0.2 0.1 0.7 -0.4 0.2 -0.0 1.1
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 8.3 0.3 0.3 0.6 -0.9 0.6 -0.3 0.3 -0.3 1.2 -1.4 -2.1 -2.9 -0.6 -2.0 -2.0
Glaucoma (self-reported) 0.4 0.4 1.7 -0.3 0.5 0.1 -0.7 0.5 -0.4 0.3 -0.7 -0.2 0.3 1.1 0.2 -0.8 0.9 1.3
Gout (self-reported) 0.2 0.3 0.9 0.3 0.5 -0.2 -1.0 0.0 0.1 0.4 0.1 0.9 -0.1 -0.4 -0.9 -0.8 0.2 -0.7
Hypothyroidism/myxoedema (self-reported) 1.2 2.4 9.3 -1.4 1.5 1.9 -1.5 -0.9 -1.8 1.6 -1.6 -3.0 -1.8 -0.8 -0.5 -0.9 -1.6 -0.8
Medication: Amlodipine 1.2 1.6 9.1 -1.5 0.6 1.0 0.5 0.6 -0.7 0.6 -0.7 0.5 1.0 2.1 1.6 -0.4 1.1 3.0
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.9 0.6 -0.4 0.0 0.4 -0.6 0.6 -0.2 0.4 0.9 -0.3 0.6 -0.5 0.3 -0.6 -0.1
Birth weight 1.7 3.7 17.4 -1.1 0.4 -0.4 0.6 2.2 -0.2 0.2 -0.9 1.1 2.4 2.9 2.6 -1.1 2.7 4.2
Chronic bronchitis/emphysema (mother) 1.0 1.2 4.0 -0.4 0.0 -0.3 0.8 1.0 -0.0 -0.4 0.2 -0.7 1.5 2.0 1.6 -0.0 1.6 1.9
High blood pressure (siblings) 1.1 1.5 6.2 -0.1 -0.5 -0.9 1.4 -0.7 0.7 -0.1 0.0 -0.2 0.9 2.5 2.2 0.5 1.1 2.4
Forced vital capacity (FVC), Best measure 12.6 46.1 78.1 7.2 -7.6 -7.3 8.8 -2.7 8.5 -8.1 8.8 4.2 6.5 6.4 5.5 7.9 4.6 3.5
Body fat percentage 23.4 92.4 207.4 -14.4 11.5 12.7 -9.9 2.9 -13.5 13.2 -13.2 -7.3 -6.2 -2.0 -1.1 -11.4 -2.1 4.0
Leg fat percentage (right) 26.0 94.2 196.0 -14.0 11.9 12.4 -10.5 2.9 -13.5 13.3 -13.4 -7.2 -6.7 -2.9 -1.9 -11.7 -2.6 3.4
Arm fat-free mass (right) 1.2 6.2 23.4 -0.5 -1.3 -1.5 2.5 0.1 1.0 -1.0 1.8 -1.4 2.6 3.2 4.8 1.4 3.7 4.3
Exposure to tobacco smoke outside home 1.9 2.6 6.1 -2.4 1.5 2.4 -1.7 0.5 -2.5 2.0 -2.0 -1.6 -0.6 -0.2 0.9 -1.8 -0.3 1.3
Comparative body size at age 10 96.2 265.6 519.8 -22.8 19.5 21.3 -18.0 4.8 -22.6 22.0 -22.7 -10.3 -13.5 -6.2 -5.3 -18.8 -7.4 3.2
Number of full brothers 2.3 2.9 6.9 -1.4 2.4 1.7 -2.4 0.2 -2.2 2.4 -2.5 -1.1 -0.7 0.0 0.3 -2.6 1.1 0.6
Worry too long after embarrassment 1.3 2.2 4.7 -1.9 2.2 1.4 -1.5 1.9 -1.9 1.9 -2.1 0.0 -0.5 -0.6 -0.9 -2.0 0.2 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 3.0 -0.4 0.1 -1.0 -0.3 1.7 0.2 -0.6 0.1 -0.3 0.7 -0.7 0.1 -0.4 0.6 -0.8
Wheeze or whistling in the chest in last year 0.7 1.2 4.1 -1.9 1.2 1.6 -0.2 0.3 -1.2 1.4 -1.1 -1.2 -0.1 0.3 0.2 -0.6 0.2 2.0
Number of children fathered 0.7 0.8 2.4 0.7 -0.7 -0.6 1.0 -1.5 1.1 -1.0 1.6 0.6 0.1 0.5 0.2 1.4 -0.2 0.6
Reason for reducing amount of alcohol drunk: Health precaution 4.5 5.3 10.4 2.6 -2.7 -2.8 3.2 -1.4 3.1 -2.9 2.8 1.6 1.8 1.1 1.4 3.1 1.2 0.4
Age at first live birth 1.4 2.5 6.7 2.2 -1.4 -1.9 1.2 1.3 2.0 -1.8 2.0 2.6 1.4 -0.6 -1.2 1.1 0.9 -0.9
Pulse wave peak to peak time 0.6 0.8 1.8 1.0 -1.1 -1.1 0.6 -0.5 0.9 -1.0 0.7 0.3 0.7 1.3 1.3 0.5 0.8 -0.7
Health satisfaction 0.7 0.9 2.5 -1.2 1.2 0.8 -0.7 0.7 -0.8 0.9 -0.9 0.0 0.6 0.8 1.1 -1.5 0.4 1.6
Shortness of breath walking on level ground 0.3 0.3 1.0 -0.4 0.5 0.5 0.1 -0.7 -0.4 0.5 -0.6 -1.0 -0.0 1.0 0.7 -0.2 0.0 0.9
Qualifications: College or University degree 0.6 1.8 3.5 -0.1 -1.1 -1.5 1.7 1.5 1.0 -1.4 0.8 0.2 1.8 1.6 1.7 0.9 1.9 1.6
Eye problems/disorders: None of the above 2.5 2.9 6.4 2.5 -1.6 -0.9 1.1 -2.0 2.1 -1.8 2.1 0.7 -0.5 -1.2 -1.2 2.3 -1.7 -2.2
Mouth/teeth dental problems: Loose teeth 5.0 6.0 15.0 -2.8 3.0 1.9 -2.7 3.9 -3.0 2.4 -3.0 -1.6 0.7 -0.9 -1.1 -3.5 1.5 1.8
Emphysema/chronic bronchitis 0.3 0.4 1.9 1.1 -0.4 -0.2 0.5 -1.4 0.4 -0.2 0.3 0.0 0.2 -0.2 -0.6 0.7 0.3 -0.8
Medication for pain relief, constipation, heartburn 1.5 2.6 10.1 0.4 0.5 0.5 -1.3 0.6 -0.2 0.2 -0.2 1.1 -2.5 -2.5 -3.0 -0.6 -3.2 -1.9
Neck or shoulder pain in last month 0.9 1.3 4.7 -0.9 0.7 1.2 -1.0 -0.8 -0.9 0.8 -0.8 -1.5 -1.8 -1.4 -0.6 -0.6 -2.2 -1.1
Medication: Blood pressure 2.2 3.9 18.3 -0.4 -0.8 -0.6 1.7 -1.1 0.9 -0.8 0.7 -0.4 2.3 3.1 4.3 1.1 2.3 3.4
Angina (self-reported) 3.6 4.7 12.5 -2.7 2.1 2.2 -2.2 -1.4 -2.6 2.2 -1.9 -3.5 -2.8 -1.7 -0.6 -1.7 -2.2 -1.1
Migraine (self-reported) 1.7 2.1 3.9 -2.0 1.8 1.5 -1.4 -0.1 -1.6 1.8 -1.6 -1.2 -1.9 -1.6 -0.4 -1.3 -1.5 -0.1
Medication: Ibuprofen 2.1 2.5 8.3 -0.1 -0.6 -0.9 1.6 -0.5 0.8 -0.8 1.0 -1.2 2.3 2.4 2.1 1.3 2.9 2.2
Medication: Allopurinol 0.4 0.5 2.1 0.1 1.0 -0.2 -1.2 0.6 -0.1 0.5 -0.3 1.3 -0.0 -0.6 0.0 -1.4 0.5 -0.3
Medication: Omeprazole 3.0 3.6 14.0 0.5 -0.8 -1.7 1.5 -0.5 1.3 -0.9 0.8 1.6 2.4 2.8 3.7 0.6 2.7 2.5
Medication: Seretide 50 evohaler 0.1 0.1 0.4 -0.1 -0.3 0.6 -0.2 0.3 -0.2 -0.2 0.5 -0.2 -0.1 -0.2 -0.2 0.6 -0.4 -0.1
Mean time to correctly identify matches 3.2 6.0 17.1 4.1 -3.2 -2.7 2.1 -0.8 3.5 -3.2 3.5 2.6 1.3 -0.5 -0.8 2.2 -0.1 -1.4
Heart disease (mother) 1.8 2.2 15.2 -1.8 0.5 1.2 0.1 -3.9 -0.6 1.3 -0.6 -1.0 -1.4 1.5 2.2 0.1 -0.3 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.0 2.3 5.4 1.7 -1.9 -1.1 1.4 0.0 1.9 -1.4 1.4 2.3 -0.2 -0.9 -1.8 1.6 -2.1 -1.3
Whole body fat mass 15.3 63.9 156.2 -12.5 9.3 10.5 -7.6 2.7 -11.3 11.0 -10.8 -6.8 -4.5 -0.9 0.3 -9.2 -0.9 4.7
Leg fat mass (right) 19.1 74.0 166.4 -12.9 10.4 11.1 -8.8 2.8 -12.1 11.8 -11.7 -7.0 -5.3 -1.9 -0.3 -10.2 -1.4 4.2
Arm predicted mass (right) 1.1 5.9 22.3 -0.5 -1.3 -1.4 2.5 0.1 1.0 -1.0 1.7 -1.4 2.5 3.1 4.7 1.5 3.4 4.3
Pulse rate, automated reading 2.1 6.7 19.4 1.6 -2.4 -2.6 2.6 3.1 2.3 -2.3 2.1 1.9 4.4 2.0 0.9 2.0 3.9 2.6
Alcohol intake frequency. 1.2 2.8 5.0 -2.2 2.0 1.7 -2.1 1.3 -1.6 1.8 -2.2 -0.8 -1.1 -1.6 -1.2 -2.2 -1.7 -0.5
Comparative height size at age 10 9.4 51.7 104.0 5.4 -7.8 -6.8 10.2 -3.2 8.3 -7.4 7.8 4.2 7.7 8.0 8.3 8.1 5.5 6.1
Number of full sisters 0.3 0.4 1.1 -0.4 0.8 0.5 -0.9 0.6 -0.4 0.7 -0.6 -0.4 0.3 -0.8 -1.0 -0.5 0.3 0.1
Suffer from ‘nerves’ 0.4 0.6 4.5 0.1 0.1 -0.0 0.8 1.3 0.6 -0.4 0.3 2.1 0.5 0.5 -0.1 0.2 -0.5 0.7
Overall health rating 1.2 2.5 8.5 -2.9 1.5 2.1 -0.8 0.2 -1.9 2.2 -2.2 -1.6 -0.3 0.6 0.4 -1.4 -0.2 2.0
Chest pain or discomfort 0.3 0.5 1.7 -0.6 1.1 0.1 -0.6 -0.2 -0.8 0.7 -0.5 -1.3 0.1 0.2 0.6 -0.8 1.1 0.3
Had major operations 0.7 0.8 2.6 1.2 -0.8 -1.6 0.3 0.5 1.0 -1.0 1.6 -0.7 0.1 -1.3 -0.6 0.5 0.1 -0.7
Age at last live birth 2.4 3.5 7.6 2.8 -2.1 -2.1 1.8 0.2 2.7 -2.2 2.5 2.7 1.2 0.3 -0.8 1.7 0.5 -1.1
Family relationship satisfaction 0.4 0.5 1.3 0.6 -0.8 -1.0 0.7 0.2 0.9 -0.7 0.9 1.1 0.6 -0.5 -0.1 0.6 0.1 -0.4
Leg pain on walking 0.6 0.7 1.8 -0.8 0.9 0.6 -0.9 -0.4 -1.0 0.7 -0.8 -1.4 -0.1 0.1 1.1 -1.3 0.6 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.7 0.3 0.2 0.9 -0.5 -0.4 -0.3 0.1 -0.3 0.7 0.2 -0.1 0.2 0.1 -0.3 -0.4
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.5 0.3 0.1 0.0 -0.2 -0.4 0.1 -0.2 0.2 -0.7 0.1 -0.5 0.5 0.1 0.1 -0.4
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.5 0.2 -0.9 -0.6 1.5 0.8 1.2 -0.9 0.6 1.3 0.2 1.2 0.1 0.9 -0.8 1.6
Medication: Aspirin 0.3 0.5 1.8 -0.2 -0.5 -0.5 0.4 -1.2 0.2 -0.3 0.5 -0.7 -0.4 -0.3 1.4 0.5 0.0 -1.3
Supplements: Vitamin C 0.5 0.6 1.7 1.3 -0.5 -1.0 0.4 -0.9 0.7 -0.7 1.0 -0.7 0.3 -0.1 0.5 0.8 0.4 -1.1
Knee pain experienced in last month 0.8 1.3 4.3 -1.2 0.5 0.3 -0.4 1.8 -0.7 0.6 -0.5 -1.2 1.5 0.4 0.7 -0.9 2.1 1.8
Hypertension (Self-reported) 4.0 11.1 37.9 -0.7 -2.0 -0.8 3.9 -1.1 1.8 -1.2 0.9 1.8 3.8 6.1 5.6 2.4 3.2 6.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 2.9 -0.4 0.2 -0.5 0.2 -0.8 -0.1 0.4 -0.2 -0.6 0.4 0.9 1.7 -0.1 1.3 0.9
Illnesses of father: Heart disease 1.4 1.9 8.7 -1.8 1.6 0.6 -1.7 -1.1 -1.5 1.5 -1.3 -2.9 -0.9 0.0 1.2 -1.2 0.2 -0.5
Illnesses of siblings: Diabetes 0.2 0.3 1.2 0.4 -0.8 -0.5 0.0 -0.2 0.5 -0.0 0.1 -0.3 -0.5 -0.4 -0.9 0.3 -1.1 -0.3
Smoking status: Previous 5.5 8.2 20.1 -3.4 4.0 2.8 -3.4 2.4 -3.7 4.0 -3.7 -1.0 -0.7 -0.9 -0.3 -4.5 1.0 1.8
Forced expiratory volume in 1-second (FEV1), predicted 7.0 14.6 33.3 3.4 -4.5 -4.7 5.8 -1.8 5.0 -4.9 5.4 0.9 2.3 3.0 2.4 5.3 0.5 1.2
Whole body fat-free mass 1.2 6.7 23.6 -0.7 -1.7 -1.3 3.0 0.2 1.1 -1.1 1.9 -1.2 2.7 3.4 4.9 1.7 3.5 4.5
Leg fat-free mass (right) 0.7 3.9 13.3 -3.4 0.8 1.5 0.2 0.8 -1.9 1.8 -0.9 -2.7 0.2 1.8 3.0 -0.9 1.6 3.6
Arm fat percentage (left) 31.9 127.1 275.6 -16.6 13.3 14.8 -12.0 4.1 -16.0 15.2 -15.5 -8.9 -7.3 -3.0 -1.7 -13.4 -2.6 4.1
Average weekly red wine intake 0.6 0.9 5.8 0.4 -0.4 -0.5 1.0 -1.5 0.6 -0.4 1.2 0.1 -0.2 0.9 2.4 0.7 0.4 0.7
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.1 0.9 -0.8 -1.0 0.4 1.0 0.8 -0.7 0.8 1.4 0.2 0.1 -1.2 0.3 -0.0 -0.3
Mood swings 0.5 0.8 2.4 -0.5 1.3 0.9 -0.4 1.2 -0.8 1.0 -1.0 1.6 0.7 -0.3 -0.6 -1.3 0.6 0.6
Loneliness, isolation 2.6 3.6 7.6 -2.0 2.0 2.6 -2.1 1.6 -2.8 1.9 -2.6 -1.9 -1.1 -1.5 -1.0 -2.4 -0.9 -0.5
Long-standing illness, disability or infirmity 2.0 3.0 8.1 -2.8 2.0 1.8 -1.5 -0.1 -2.2 2.2 -2.3 -2.5 -1.5 -0.3 -0.3 -1.8 -0.9 0.3
Ever had bowel cancer screening 1.0 1.2 2.8 1.7 -1.1 -1.5 1.3 -0.5 1.5 -1.2 1.2 1.3 0.3 1.3 0.8 0.8 -0.3 0.5
Diabetes diagnosed by doctor 2.3 3.8 9.8 -3.1 1.7 2.3 -2.0 3.1 -2.3 2.1 -2.5 -0.6 0.2 -0.9 -0.7 -2.3 -0.1 1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.7 4.1 1.7 -1.1 -1.6 0.9 0.6 1.2 -1.7 1.6 -0.6 1.8 0.8 0.1 1.1 2.0 0.9
Friendships satisfaction 1.1 1.3 3.0 1.2 -1.3 -1.0 0.6 -1.0 1.2 -0.9 1.6 0.5 -1.1 -1.0 -0.7 1.4 -1.5 -1.7
Qualifications: nursing, teaching 0.4 0.7 4.5 -0.9 -0.6 -0.4 0.0 -1.2 -0.2 0.1 -0.2 -2.1 -0.6 -0.1 0.5 0.5 -0.1 -1.1
Commuting to job workplace: Walk 0.4 0.5 1.9 0.5 -0.5 -0.5 0.3 0.2 0.7 -0.3 0.4 1.4 -0.8 -0.3 -0.7 0.2 -1.4 -0.6
Eye problems/disorders: Cataract 0.9 1.0 2.2 -0.8 0.9 0.4 -0.2 1.4 -0.9 0.9 -0.8 0.9 0.8 1.0 1.5 -1.3 1.4 1.3
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 4.4 1.0 -1.1 -1.3 1.3 0.1 1.5 -1.0 1.4 1.0 1.9 1.7 1.1 1.4 2.1 1.9
Medication for cholesterol 1.6 2.5 10.5 0.9 0.7 0.4 -1.2 -0.5 -0.2 0.4 -0.0 0.0 -1.9 -2.8 -2.7 -0.5 -2.0 -3.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.6 1.1 -0.4 -1.3 0.7 1.2 0.7 -1.1 1.1 0.4 1.6 0.6 0.5 0.4 1.5 1.2
Back pain experienced in last month 0.2 0.3 0.7 -0.0 -0.4 -0.3 0.7 -0.8 0.5 -0.4 0.7 -0.8 -0.2 -0.3 -0.7 0.8 -0.8 -0.4
Mineral and other dietary supplements 0.8 1.0 2.2 -0.6 0.9 1.5 -0.9 -0.2 -1.0 1.0 -1.0 0.8 -1.1 -1.2 -1.3 -0.4 -1.5 -0.9
Breast cancer (self-reported) 0.7 0.9 2.5 1.1 -1.2 0.2 0.8 1.1 1.0 -0.9 0.8 1.6 1.2 0.2 -0.9 0.7 0.0 0.8
Asthma (self-reported) 0.7 1.4 3.3 -1.8 1.6 1.5 -1.0 0.9 -1.3 1.6 -1.5 0.3 -1.2 -0.6 -0.9 -1.2 -0.9 0.9
Osteoporosis (self-reported) 0.7 0.9 3.2 -1.7 -0.3 -0.0 0.8 -0.8 -0.3 0.2 0.1 -1.8 -0.2 1.5 1.1 0.8 0.3 1.1
Osteoarthritis (self-reported) 3.4 4.4 10.8 -2.6 2.9 2.9 -2.4 -0.4 -2.6 3.3 -2.9 -0.8 -0.6 -0.7 0.2 -2.7 0.6 0.8
Medication: Aspirin 0.5 0.6 2.9 -0.2 -0.7 -0.6 0.6 -1.7 0.4 -0.3 0.5 -0.8 -0.5 -0.1 1.6 0.7 -0.1 -1.1
Medication: Gliclazide 0.2 0.2 1.3 -1.1 -0.2 0.8 0.1 -0.0 -0.2 0.3 -0.2 -0.6 0.1 0.4 -0.2 0.3 -0.4 0.3
Illnesses of father: None of the above (group 1) 0.9 1.2 3.1 -0.9 0.7 0.8 -1.3 1.6 -1.1 0.7 -0.7 -0.0 -0.8 -1.7 -1.8 -1.3 -0.6 -0.7
Smoking status: Current 1.2 1.8 5.6 -1.4 1.3 1.8 -0.9 -1.4 -1.6 1.6 -1.2 -2.4 -1.7 -0.2 -0.4 -0.8 -1.4 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 5.2 0.3 -0.7 -1.4 1.3 -0.6 0.9 -0.6 0.9 0.5 1.3 2.1 2.1 0.9 2.3 2.1
Whole body water mass 1.2 7.0 24.2 -0.7 -1.7 -1.3 3.1 0.2 1.0 -1.1 1.9 -1.2 2.8 3.5 4.9 1.8 3.7 4.7
Leg predicted mass (right) 0.7 3.8 13.1 -3.4 0.7 1.5 0.3 0.7 -1.9 1.7 -0.8 -2.7 0.2 1.8 3.0 -0.8 1.6 3.6
Arm fat mass (left) 19.8 81.4 193.2 -13.9 10.4 11.9 -8.8 3.5 -12.9 12.2 -12.2 -7.7 -5.1 -1.3 -0.0 -10.5 -1.0 5.1
Number of self-reported non-cancer illnesses 0.9 1.6 8.3 -0.7 0.1 0.2 0.9 -1.1 -0.0 0.4 -0.7 -0.5 1.1 2.9 1.8 0.2 1.1 2.6
Average weekly champagne plus white wine intake 0.7 0.9 1.9 1.4 -1.3 -0.4 1.4 -1.3 1.0 -0.7 0.9 1.3 0.3 0.8 -0.3 1.3 0.2 -0.2
Miserableness 2.9 5.0 10.8 -2.6 3.2 3.3 -2.5 1.4 -2.9 3.0 -2.8 0.6 -1.3 -1.1 -1.2 -2.8 -1.0 0.2
Guilty feelings 2.6 4.0 8.6 -2.6 2.5 2.2 -2.1 2.6 -2.6 2.3 -2.8 -0.7 0.3 0.0 -0.1 -2.9 0.8 0.7
Wears glasses or contact lenses 0.4 0.5 2.1 -1.0 0.1 0.3 0.9 -0.1 -0.2 -0.1 -0.2 -0.6 0.5 1.5 0.7 0.3 0.8 1.3
Ever taken oral contraceptive pill 0.6 0.7 2.6 0.7 -0.3 -0.4 0.7 1.1 0.5 -0.8 0.7 0.6 1.6 0.2 0.2 0.4 1.5 1.0
Hearing aid user 6.6 7.5 15.5 -3.0 3.9 3.6 -3.2 1.2 -3.8 3.9 -3.9 -1.1 -0.9 0.3 -0.2 -3.6 0.7 1.5
Mother’s age at death 0.8 1.1 2.4 -0.7 0.8 1.0 -1.2 0.5 -1.2 1.0 -1.0 0.1 -1.5 -1.4 -1.1 -1.1 -1.1 -0.4
Financial situation satisfaction 0.1 0.2 0.7 0.3 0.5 0.2 -0.2 0.4 -0.1 0.3 -0.1 0.6 0.7 0.0 0.2 -0.3 0.8 0.4
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.6 -1.0 1.4 0.8 -1.0 -0.0 -1.3 1.4 -1.3 -0.1 -0.0 0.6 1.9 -1.5 1.5 0.9
Commuting to job workplace: Public transport 0.6 0.7 2.2 -0.5 0.9 0.4 -1.0 1.0 -0.9 0.9 -0.9 0.8 -0.1 -0.4 -0.4 -1.5 1.0 0.1
Eye problems/disorders: Glaucoma 0.1 0.1 0.5 -0.2 0.3 0.1 -0.4 -0.3 -0.2 0.4 -0.5 -0.1 -0.1 0.3 -0.1 -0.3 0.0 0.7
Medication: Blood pressure 3.6 6.8 23.2 -0.5 -2.0 -1.0 3.2 -0.2 1.5 -1.2 0.8 1.5 3.0 4.8 4.0 1.9 2.5 4.5
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.7 -1.0 0.3 0.5 0.1 -1.4 -0.5 0.7 -0.7 -1.6 -0.0 1.3 1.6 0.4 0.9 0.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.3 1.5 -1.0 -1.5 0.9 -0.3 1.3 -1.1 1.2 0.5 0.8 0.8 1.3 0.6 1.1 0.3
High cholesterol (Self-reported) 0.7 1.3 4.6 -1.3 1.0 0.1 -0.5 -0.0 -0.7 0.9 -1.1 -1.2 0.7 1.0 1.9 -0.9 1.5 2.1
Medication: Bendroflumethiazide 3.1 4.7 22.7 -2.4 0.2 1.0 0.9 1.1 -0.9 0.8 -1.5 0.4 2.0 3.5 3.6 -0.7 2.4 4.8
Medication: Paracetamol 1.4 2.2 6.7 -1.7 0.8 0.7 0.1 -0.8 -1.2 1.4 -1.4 -2.0 1.1 2.2 1.8 -0.9 2.6 1.6
Medication: Lisinopril 2.4 3.1 12.0 -0.4 -0.9 -1.5 1.6 0.1 1.2 -0.8 0.8 1.1 2.1 2.3 3.5 1.0 2.3 2.8
Medication: Atorvastatin 0.5 0.6 2.5 0.9 -0.2 -1.5 -0.1 -0.1 0.4 -0.6 0.4 -1.2 0.7 0.2 0.8 -0.1 1.6 -0.6
Illnesses of father: High blood pressure 4.6 5.6 17.6 0.9 -2.0 -1.2 3.4 -1.8 1.9 -1.6 1.3 -0.3 2.3 4.2 3.2 2.8 2.1 3.2
Alcohol drinker status: Never 1.5 1.8 9.6 -0.2 0.6 0.7 -1.5 0.6 -0.5 0.3 -0.4 -0.1 -1.0 -3.1 -1.5 -0.8 -1.7 -2.6
Ever smoked 3.0 5.3 10.3 -3.0 3.2 2.7 -2.2 1.4 -3.1 3.2 -3.0 -2.0 -0.4 -0.2 -0.4 -3.2 0.8 1.8
Basal metabolic rate 1.0 5.3 23.2 -3.0 0.1 0.8 1.4 0.6 -1.1 1.0 -0.2 -2.3 1.5 2.9 4.3 -0.0 2.8 4.8
Leg fat percentage (left) 26.2 94.7 196.0 -14.0 11.9 12.5 -10.6 2.8 -13.5 13.3 -13.4 -7.3 -6.8 -3.0 -2.2 -11.6 -2.7 3.4
Arm fat-free mass (left) 1.2 5.9 23.0 -1.4 -1.0 -0.8 2.4 0.8 0.4 -0.5 1.1 -1.6 2.7 3.1 4.4 1.1 3.7 4.8
Number of operations (self-reported) 1.2 1.8 6.5 -1.0 0.5 -0.2 -0.2 -0.9 -0.5 0.9 -0.3 -2.2 0.7 1.4 2.5 -0.6 2.1 2.2
Average weekly beer plus cider intake 0.3 0.5 1.7 -0.7 0.5 1.0 -0.1 0.6 -0.8 0.5 -0.7 -0.7 -0.1 0.4 -0.7 -0.6 -0.4 1.3
Irritability 1.6 2.7 5.9 -2.2 2.2 2.2 -1.4 1.2 -2.2 2.3 -2.4 -0.1 -0.7 -0.4 -0.4 -2.3 -0.4 0.7
Risk taking 0.2 0.4 1.7 1.3 -0.1 -0.9 -0.3 0.6 0.2 -0.4 0.7 0.2 0.4 -0.7 0.1 -0.4 0.7 -0.7
Ever had prostate specific antigen (PSA) test 1.5 1.7 6.0 2.4 -0.7 -1.7 0.4 -1.0 1.7 -1.5 1.5 1.0 0.0 -0.7 -0.3 0.9 -0.1 -2.2
Fractured/broken bones in last 5 years 0.8 1.0 3.7 -1.6 1.1 1.1 -0.0 -0.7 -1.0 1.2 -1.0 -0.9 -0.6 0.6 1.9 -0.4 0.1 0.9
Age started oral contraceptive pill 0.4 0.5 2.1 -0.3 1.1 0.1 -1.2 1.0 -0.7 0.6 -0.8 0.5 0.1 -0.2 0.4 -1.5 0.6 0.2
Diastolic blood pressure, automated reading 2.8 8.7 18.1 1.1 -2.5 -2.1 4.1 -0.3 2.7 -2.3 2.5 2.3 3.8 4.2 2.6 3.2 3.3 4.3
Ever depressed for a whole week 1.2 1.5 4.3 -0.4 1.4 0.9 -1.3 1.2 -0.8 1.1 -0.9 1.4 -0.8 -1.2 -1.9 -2.1 -1.0 -0.7
Unable to work because of sickness or disability 1.9 2.4 8.2 -2.8 1.2 1.4 -1.1 0.1 -2.0 1.8 -1.9 -2.9 -0.5 0.7 0.8 -1.1 0.3 1.5
Commuting to job workplace: Cycle 0.5 0.6 1.4 -0.8 0.7 0.6 -0.7 1.2 -1.0 1.0 -1.2 -0.3 0.6 0.0 -0.2 -0.7 0.8 0.7
Myopia 3.6 5.2 12.5 2.6 -3.2 -1.9 3.1 -0.6 3.0 -3.1 3.4 1.2 1.1 1.1 -0.8 3.5 -0.6 -0.6
Vascular/heart problems diagnosed by doctor 2.4 6.6 28.6 1.3 0.9 -0.0 -2.6 1.0 -0.7 0.1 0.0 -0.8 -2.5 -4.8 -4.7 -1.2 -2.3 -5.3
Cholesterol lowering medication 0.8 1.2 6.1 -1.2 -0.3 -0.3 0.9 0.1 -0.1 0.0 -0.1 -0.6 0.9 1.9 2.0 0.2 1.0 2.5
Medication: Omeprazole (e.g. Zanprol) 3.6 4.4 17.0 0.3 -0.7 -1.6 1.4 -0.3 1.2 -0.7 0.4 1.6 2.8 3.3 4.1 0.5 3.3 3.1
Pain experienced in last month 0.2 0.3 1.5 0.7 0.2 -0.4 -0.1 -0.9 0.3 -0.1 -0.1 0.7 0.3 1.2 1.0 0.1 0.7 0.0
Supplements: Calcium 1.0 1.1 4.7 0.8 -0.7 -2.2 1.2 1.0 1.3 -1.2 1.0 0.2 1.1 0.3 -0.8 0.8 1.0 0.3
Basal cell carcinoma (self-reported) 0.4 0.5 1.2 1.0 -0.9 -1.1 0.5 -0.9 0.9 -0.7 0.8 0.1 -0.1 0.4 0.1 0.8 0.2 -0.6
Heart attack/myocardial infarction (self-reported) 0.9 1.2 5.3 0.6 -0.1 -0.3 -0.7 -1.9 -0.1 -0.2 0.6 -2.3 -1.2 -1.1 -0.2 0.0 -0.9 -2.0
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 5.5 -0.2 0.3 0.6 -0.9 -1.4 -0.4 0.6 -0.3 -0.0 -2.3 -1.8 -1.1 -0.6 -2.4 -2.0
Heart disease (siblings) 4.0 4.9 10.6 -2.6 3.2 1.7 -3.3 0.4 -2.5 2.9 -2.5 -1.6 -2.3 -2.0 -0.6 -2.9 -0.9 -0.4
Alcohol drinker status: Previous 0.6 0.6 1.8 -0.4 1.3 0.2 -0.7 0.9 -0.6 0.8 -1.0 -0.1 0.8 0.3 0.4 -1.1 1.4 0.8
Pack years of smoking 3.1 4.6 8.8 -3.0 2.3 2.7 -2.3 1.3 -2.9 2.6 -2.6 -2.8 -1.1 -0.8 -1.1 -2.5 -0.9 0.7
Impedance of whole body 2.9 14.9 28.8 5.0 -4.5 -4.0 5.0 -2.7 5.4 -4.9 5.0 4.0 2.6 2.3 0.9 4.7 0.2 -1.2
Leg fat mass (left) 19.0 74.0 166.4 -12.9 10.4 11.1 -8.8 2.7 -12.1 11.8 -11.7 -7.0 -5.5 -2.0 -0.5 -10.1 -1.5 4.1
Arm predicted mass (left) 1.3 6.6 26.0 -1.3 -1.0 -0.8 2.6 0.5 0.5 -0.4 1.2 -1.4 2.9 3.4 4.7 1.2 3.9 5.1