Best TWAS P=1.79e-09 · Best GWAS P=4.24e-10 conditioned to 0.0781
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BTBD1 | 0.07 | 0.01 | bslmm | 356 | 0.04 | 1.7e-05 | -3.2 | -5.4 | 7.2e-08 | -0.39 | 0.69 | 0.08 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | WHAMM | 0.46 | 0.45 | lasso | 3 | 0.47 | 2.7e-42 | -4.7 | 5.4 | 8.0e-08 | 0.77 | 0.93 | 0.07 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | RP11-382A20.2 | 0.13 | 0.03 | enet | 20 | 0.07 | 1.1e-03 | 2.3 | 5.4 | 6.3e-08 | 0.38 | 0.11 | 0.16 | FALSE |
| 4 | GTEx | Testis | BTBD1 | 0.06 | 0.01 | enet | 8 | 0.04 | 1.1e-02 | 3.4 | -5.3 | 8.9e-08 | -0.39 | 0.11 | 0.31 | TRUE |
| 5 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | WHAMM | 0.14 | 0.05 | enet | 11 | 0.08 | 1.0e-04 | -5.0 | 6.0 | 1.8e-09 | 0.79 | 0.01 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Rectum Adenocarcinoma | WHAMM | 0.25 | 0.06 | blup | 55 | 0.09 | 4.2e-03 | -5.0 | 5.8 | 5.6e-09 | 0.81 | 0.01 | 0.78 | FALSE |
| 7 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | WHAMM | 0.14 | 0.17 | enet | 5 | 0.13 | 2.5e-04 | -5.6 | -5.8 | 6.1e-09 | -0.70 | 0.02 | 0.43 | FALSE |