Best TWAS P=4e-17 · Best GWAS P=2.21e-17 conditioned to 0.0754
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HYKK | 0.08 | 0.01 | lasso | 2 | 0.01 | 3.0e-02 | 4.3 | 6.8 | 8.9e-12 | -0.80 | 0.04 | 0.77 | FALSE |
| 2 | GTEx | Colon Sigmoid | CHRNA5 | 0.20 | -0.01 | enet | 14 | 0.03 | 2.9e-02 | -7.4 | 6.2 | 5.4e-10 | -0.49 | 0.04 | 0.61 | FALSE |
| 3 | GTEx | Heart Left Ventricle | PSMA4 | 0.18 | 0.02 | enet | 21 | 0.06 | 4.4e-04 | 4.1 | -6.1 | 9.5e-10 | 0.71 | 0.10 | 0.77 | FALSE |
| 4 | GTEx | Liver | PSMA4 | 0.18 | 0.14 | lasso | 1 | 0.11 | 6.5e-04 | -8.2 | -8.2 | 1.8e-16 | 0.94 | 0.01 | 0.94 | FALSE |
| 5 | GTEx | Testis | CHRNA5 | 0.16 | 0.07 | enet | 11 | 0.11 | 1.4e-05 | -8.2 | -6.7 | 1.8e-11 | 0.81 | 0.06 | 0.89 | FALSE |
| 6 | YFS | Blood | IREB2 | 0.18 | 0.20 | enet | 28 | 0.24 | 4.0e-78 | -8.4 | 7.4 | 9.5e-14 | -0.76 | 0.01 | 0.99 | FALSE |
| 7 | YFS | Blood | PSMA4 | 0.08 | 0.08 | lasso | 10 | 0.11 | 8.3e-35 | -8.5 | -8.1 | 5.3e-16 | 0.88 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CHRNA3 | 0.02 | 0.02 | blup | 44 | 0.02 | 4.8e-05 | 4.3 | 5.4 | 7.2e-08 | -0.67 | 0.29 | 0.52 | FALSE |
| 9 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA3 | 0.24 | 0.15 | enet | 5 | 0.16 | 6.5e-06 | -8.2 | 7.5 | 4.5e-14 | -0.90 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA5 | 0.17 | 0.15 | lasso | 4 | 0.14 | 3.1e-05 | -8.2 | 8.4 | 4.0e-17 | -0.93 | 0.00 | 0.98 | TRUE |
| 11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADAMTS7 | 0.08 | 0.07 | lasso | 3 | 0.06 | 4.2e-04 | -5.6 | -5.5 | 3.7e-08 | 0.58 | 0.00 | 0.96 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CHRNA5 | 0.12 | 0.15 | blup | 50 | 0.14 | 1.4e-08 | 4.2 | 5.4 | 6.8e-08 | -0.68 | 0.98 | 0.02 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADAMTS7 | 0.08 | 0.07 | lasso | 3 | 0.07 | 4.9e-08 | -5.5 | -5.5 | 3.2e-08 | 0.57 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSMA4 | 0.08 | 0.02 | blup | 40 | 0.03 | 1.1e-02 | 5.2 | 5.5 | 3.1e-08 | -0.54 | 0.04 | 0.25 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHRNA5 | 0.02 | 0.01 | blup | 50 | 0.02 | 2.6e-03 | 4.3 | 7.0 | 2.0e-12 | -0.83 | 0.01 | 0.77 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMA4 | 0.03 | 0.02 | blup | 40 | 0.02 | 3.1e-03 | 4.3 | -6.5 | 6.3e-11 | 0.81 | 0.02 | 0.61 | FALSE |
| 17 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CHRNA5 | 0.15 | 0.07 | blup | 50 | 0.09 | 2.5e-04 | 4.2 | 6.1 | 9.6e-10 | -0.64 | 0.17 | 0.56 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHRNA3 | 0.04 | 0.04 | blup | 44 | 0.06 | 1.4e-06 | -7.8 | 7.2 | 6.2e-13 | -0.80 | 0.02 | 0.98 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHRNA5 | 0.04 | 0.01 | enet | 10 | 0.03 | 6.0e-04 | -8.2 | 7.0 | 1.8e-12 | -0.75 | 0.01 | 0.84 | FALSE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CHRNA3 | 0.05 | 0.02 | blup | 44 | 0.02 | 7.6e-03 | -8.2 | 7.4 | 1.8e-13 | -0.86 | 0.00 | 0.97 | FALSE |
| 21 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PSMA4 | 0.11 | 0.01 | blup | 40 | 0.03 | 3.0e-02 | 4.3 | -5.9 | 3.8e-09 | 0.74 | 0.05 | 0.49 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | CHRNA5 | 0.16 | 0.25 | lasso | 6 | 0.25 | 2.7e-24 | 4.3 | 5.8 | 8.8e-09 | -0.74 | 1.00 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | CHRNB4 | 0.06 | 0.03 | lasso | 2 | 0.06 | 4.4e-06 | -5.8 | -5.4 | 5.3e-08 | 0.61 | 0.29 | 0.66 | FALSE |