Best TWAS P=1.9e-09 · Best GWAS P=3.32e-09 conditioned to 0.359
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | TSEN54 | 0.12 | 0.00 | lasso | 5 | 0.00 | 3.0e-01 | 4.4 | -5.5 | 4.2e-08 | -0.58 | 0.02 | 0.88 | FALSE |
| 2 | GTEx | Esophagus Muscularis | LLGL2 | 0.23 | 0.17 | lasso | 4 | 0.17 | 2.0e-10 | 5.9 | 6.0 | 2.1e-09 | 0.97 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Heart Left Ventricle | LLGL2 | 0.23 | 0.09 | lasso | 5 | 0.11 | 2.5e-06 | 5.9 | 6.0 | 1.9e-09 | 0.93 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Muscle Skeletal | LLGL2 | 0.22 | 0.08 | lasso | 8 | 0.08 | 4.3e-08 | 5.9 | 5.9 | 3.1e-09 | 0.97 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Thyroid | LLGL2 | 0.08 | 0.04 | lasso | 3 | 0.04 | 4.7e-04 | 5.7 | 5.2 | 2.5e-07 | 0.85 | 0.01 | 0.90 | FALSE |