Hub : Genes

TSEN54

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1220	0.0460	2.9e-04	-0.002	NA	-0.001	NA	0.000	4.4e-01	NA	3.7e-01	NA	3.0e-01
2	GTEx	Testis	0.5040	0.0760	6.6e-07	0.339	NA	0.312	NA	0.311	9.9e-16	NA	2.1e-14	NA	2.4e-14
3	GTEx	Thyroid	0.1610	0.0510	2.6e-04	0.009	NA	0.053	NA	0.025	6.7e-02	NA	6.4e-05	NA	4.9e-03
4	YFS	Blood	0.0586	0.0142	1.1e-16	0.051	0.055	0.066	0.051	0.067	3.2e-16	1.7e-17	1.4e-20	2.1e-16	3.9e-21
5	TCGA	Prostate Adenocarcinoma	0.2177	0.0705	1.5e-05	0.010	0.059	0.043	NA	0.040	2.7e-02	7.9e-07	2.4e-05	NA	4.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.4	4.1	-0.5	-1.0	-1.1	-0.7	-2.0
Bipolar Disorder or Schizophrenia	0.4	0.9	4.1	-0.4	-0.0	-0.1	-0.2	-2.0
Depressed Affect (Nagel 2018)	1.2	2.6	3.8	-1.8	1.1	-1.7	-1.3	-2.0
Depression (Nagel 2018)	0.2	0.2	0.5	0.4	0.6	0.3	0.2	0.7
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.1	0.2	-1.0	0.4	1.0	-0.6
Neuroticism (Nagel 2018)	2.0	4.8	8.4	-2.2	1.4	-2.9	-1.9	-2.2
Schizophrenia (2018)	0.2	0.4	1.0	-0.1	0.6	0.8	0.4	-1.0
Schizophrenia vs Biploar Disorder	0.5	0.7	1.5	0.5	-0.2	0.9	1.2	1.0
Worry (Nagel 2018)	2.0	4.2	7.5	-1.6	0.7	-2.7	-2.3	-2.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.1	0.7	-0.5	1.0	0.9	1.1
Alzheimer’s Disease (in father)	0.6	0.7	1.4	-0.8	0.2	-0.7	-1.2	-0.8
Alzheimer’s Disease (including proxy)	0.0	0.0	0.2	-0.4	-0.1	-0.1	-0.1	-0.1
Crohns Disease (2017)	0.3	0.7	2.1	1.4	-0.8	0.6	-0.1	0.7
Irritable Bowel Disease (IBD)	0.6	1.4	5.7	1.0	-0.5	-0.2	-2.4	0.3
Ulcerative Colitis (UC)	1.3	2.4	11.5	0.3	-0.3	-0.6	-3.4	-0.4
Major Depression (MDD)	0.9	1.1	2.2	-0.3	1.5	1.0	-1.4	0.0
Reaction Time	0.2	0.3	1.1	-0.6	0.1	1.1	0.4	-0.1
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.0	0.1	-0.0	0.2	0.0	-0.2
Breast Cancer	1.3	3.2	8.6	-2.3	2.9	-0.0	0.6	1.4
Ovarian Cancer	0.7	0.9	3.3	-0.4	-1.8	-0.1	0.7	-0.5
Prostate Cancer	0.9	1.3	3.7	-0.6	0.1	-1.9	1.4	-0.7
Age at First Birth	0.2	0.2	0.6	-0.8	0.6	-0.1	0.5	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	1.2	1.1	0.5	-0.1	0.0	-0.3
Coronary Artery Disease (CAD)	2.6	3.1	6.8	-2.6	2.2	-1.7	0.6	0.8
Crohns Disease (2012)	0.3	0.5	1.5	0.9	-1.2	-0.0	0.5	0.2
Mean Putamen Volume	1.3	1.5	4.3	-0.3	2.1	0.8	-0.5	1.4
Fasting Glucose	1.0	1.2	2.9	0.9	-0.3	0.9	1.2	1.7
HbA1C	1.0	1.1	3.2	-0.0	1.2	0.1	0.7	1.8
HDL Cholesterol	0.5	0.9	2.7	0.5	-0.2	1.1	0.4	1.6
LDL Cholesterol	2.4	3.8	8.0	-1.4	0.3	-2.3	-1.8	-2.8
Lupus	1.5	2.3	5.0	2.2	0.1	1.6	1.9	0.5
Neuroticism (2016)	0.9	1.3	2.3	-1.3	1.1	-1.5	-1.0	-0.3
Primary Biliary Cirrhosis	0.8	1.1	2.1	-1.2	0.9	-1.4	-0.6	-1.0
Rheumatoid Arthritis	2.1	2.9	6.6	0.3	2.2	0.6	1.6	2.6
Schizophrenia (2014)	0.3	0.7	1.7	0.5	0.4	0.8	0.7	-1.3
Triglycerides	0.2	0.3	0.8	0.9	0.3	0.0	-0.4	-0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	-0.7	0.5	0.2	-1.1	0.3
Ulcerative Colitis	1.0	1.4	5.6	-0.4	1.0	-0.5	-2.4	0.2
Blood Eosinophil Count	0.2	1.4	3.8	1.9	0.3	-0.6	-1.6	0.4
Blood Platelet Count	0.7	8.1	37.3	1.3	-6.1	-0.1	-0.3	-1.1
Blood Red Count	0.7	6.8	11.5	1.9	-2.7	1.5	-3.4	-3.1
Blood White Count	0.4	3.3	6.1	1.6	-2.5	-1.7	-1.9	-1.3
Heel T-Score	0.5	3.7	10.2	0.1	-0.6	3.2	-2.3	-1.7
BMI	0.1	0.8	3.2	0.3	0.2	-0.5	1.8	0.7
Height	0.5	10.1	22.8	4.8	-2.3	3.6	-3.1	0.4
Waist Hip Ratio (WHR)	1.3	5.6	20.9	4.6	-1.5	2.1	-0.4	-0.5
Systolic Blood Pressure	0.2	1.2	2.4	0.7	-1.5	-1.2	-1.0	-0.8
Smoking Status	0.6	1.4	3.2	-1.8	0.5	-1.6	1.0	0.4
Allergy or Eczema	1.4	3.6	9.1	-1.6	2.1	-1.1	3.0	0.9
Cardiovascular Disease	0.6	1.9	4.8	2.2	-2.1	-0.1	-0.3	-0.1
Hypothyroidism (self reported)	0.5	1.2	2.2	-1.1	-0.7	-1.3	0.5	-1.5
Respiratory disease	1.5	3.3	6.4	2.5	-0.9	1.8	2.0	1.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.0	0.7	0.8	0.3	1.0	1.7
Lung FEV1/FVC ratio	1.3	6.7	10.8	-3.3	2.5	-3.0	2.3	-1.6
Lung FVC	3.5	17.9	46.1	-6.8	5.2	-3.3	1.4	-1.8
Neuroticism	1.2	3.0	4.4	-1.9	1.3	-2.1	-1.4	-1.7
Chronotype (morning person)	0.4	0.9	3.1	0.1	0.9	-0.3	-1.8	0.6
Hair Pigment	0.2	4.8	13.8	3.7	-1.0	2.3	-1.4	1.5
Tanning	0.1	1.8	5.7	-2.4	-0.1	-1.0	1.6	0.0
Hand grip strength (left)	1.7	4.5	8.4	2.9	-0.2	2.7	1.7	2.0
Number of treatments/medications taken	0.3	0.5	1.1	1.1	0.5	0.3	0.6	0.9
Average weekly spirits intake	0.5	0.6	2.2	0.6	-0.5	1.5	0.2	0.3
Sensitivity / hurt feelings	0.3	0.6	2.3	-0.5	1.5	-0.3	-0.4	-0.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.4	0.3	0.2	0.8	0.6	1.2
Hearing difficulty/problems: Yes	1.0	1.6	4.9	0.4	-2.2	0.6	-1.0	-1.1
Relative age of first facial hair	0.0	0.1	0.3	0.2	0.1	0.2	-0.5	-0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	3.5	0.2	-0.2	0.8	1.0	1.9
Ever used hormone-replacement therapy (HRT)	2.0	2.6	6.5	-2.5	1.6	-1.0	-0.1	-1.7
Ever had hysterectomy (womb removed)	1.9	2.1	5.1	-2.2	2.0	-0.6	0.2	-1.0
Systolic blood pressure, automated reading	0.3	0.9	1.9	0.7	-1.0	-0.2	-1.4	-1.1
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	3.8	0.6	0.5	1.4	1.9	1.6
Angina	0.8	1.1	2.0	-1.4	1.1	-0.8	-1.0	-0.8
Medication for hormone replacement therapy	0.2	0.3	0.8	0.7	0.0	0.9	0.2	-0.1
Vitamin and mineral supplements	2.6	3.6	7.3	1.6	-2.7	1.8	2.2	-0.2
Supplements: Zinc	0.0	0.0	0.2	0.2	0.4	-0.1	0.0	-0.0
Medication: Co-codamol	0.4	0.5	0.9	-0.9	0.7	-0.6	-0.9	-0.3
Medication: Metformin	0.8	1.2	4.3	0.9	-0.1	0.6	2.1	0.6
Diabetes (father)	1.9	2.3	4.6	1.8	-0.8	1.7	0.5	2.1
Diabetes (mother)	0.4	0.5	1.8	1.3	-0.8	-0.4	-0.1	0.3
Severe depression (siblings)	1.1	1.3	3.1	0.4	0.1	0.5	1.7	1.8
Pack years adult smoking proportion	0.2	0.4	0.9	0.9	0.1	1.0	-0.2	0.2
Impedance of leg (right)	0.6	2.8	4.8	1.2	-2.2	-0.1	-2.1	-1.8
Leg fat-free mass (left)	0.1	0.4	1.3	1.2	0.2	0.4	-0.2	0.8
Trunk fat percentage	0.4	1.5	4.0	1.6	-2.0	-0.3	-0.6	-0.6
Hand grip strength (right)	1.0	2.8	6.0	2.4	-0.5	2.1	1.6	1.0
Townsend deprivation index at recruitment	1.0	1.4	2.5	-1.6	1.5	-0.7	-1.2	0.3
Current tobacco smoking	0.4	0.6	1.5	1.2	-0.3	0.3	1.1	0.2
Average weekly fortified wine intake	0.2	0.2	0.6	0.6	0.3	0.2	0.3	0.8
Maternal smoking around birth	0.8	1.1	2.8	0.3	-1.3	0.5	0.9	-1.7
Fed-up feelings	0.9	1.6	3.9	-1.4	0.6	-2.0	0.4	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.0	1.2	-0.8	0.9	1.4	1.4
Relative age voice broke	0.8	1.3	3.7	-1.1	0.7	-1.9	-0.5	-0.9
Taking other prescription medications	1.0	1.6	5.3	-0.2	1.0	-0.6	2.3	1.1
Age when periods started (menarche)	0.5	1.1	2.4	-1.6	-0.2	-0.5	1.4	1.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.4	-1.2	-0.1	-0.3	0.9	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	-0.3	0.5	0.8	-1.2	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.3	-0.6	-0.3	0.3	0.3
Qualifications: CSEs or equivalent	1.9	2.5	5.8	2.3	-2.4	0.9	-0.4	-0.5
Serious illness, injury or assault to yourself	1.5	1.8	4.1	2.0	-0.7	0.9	0.9	1.6
High blood pressure	1.4	4.0	11.6	3.4	-2.7	0.7	0.1	0.9
Hayfever, allergic rhinitis or eczema	1.5	3.2	7.1	-1.7	1.2	-2.1	2.7	-0.3
Multivitamins +/- minerals	0.7	0.9	2.5	-0.6	1.1	-0.8	-1.6	0.2
Stomach or abdominal pain in last month	0.5	0.7	2.0	-0.3	0.3	-1.4	-0.1	-1.1
Supplements: Glucosamine	1.6	2.1	5.4	-1.9	2.3	-0.9	-0.7	0.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.2	0.6	-0.3	0.1	0.4	1.8
Medication: Atenolol	0.4	0.5	1.3	0.2	-0.6	-0.1	-1.1	-1.0
Medication: Levothyroxine sodium	0.2	0.4	0.9	-0.5	-0.5	-1.0	0.5	-0.4
Sitting height	0.1	0.8	1.8	-0.3	-1.3	-0.7	-1.1	-0.6
Chronic bronchitis/emphysema (father)	0.6	0.7	2.4	-0.2	-0.2	-0.2	-0.9	-1.6
High blood pressure (mother)	1.5	2.1	3.7	1.6	0.6	1.9	-0.5	1.8
Body mass index (BMI)	0.1	0.3	1.4	0.1	-0.5	-0.3	1.2	0.1
Impedance of leg (left)	0.5	2.4	4.8	0.4	-1.8	-0.4	-1.9	-2.2
Leg predicted mass (left)	0.1	0.4	1.1	1.1	0.2	0.4	-0.3	0.7
Trunk fat mass	0.3	1.5	4.0	2.0	-1.7	0.1	-0.6	-0.1
Waist circumference	0.3	1.2	3.8	1.9	-1.3	0.5	0.1	-0.0
Number of incorrect matches in round	0.9	1.4	4.7	0.8	-2.2	0.5	-1.2	-0.1
Past tobacco smoking	0.6	1.0	3.2	1.8	-0.0	1.4	0.1	-0.1
Alcohol usually taken with meals	1.7	2.8	5.8	0.6	0.6	2.4	1.9	1.9
Nervous feelings	0.9	1.7	6.6	-1.0	0.5	-2.6	-0.9	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.4	0.7	-0.1	1.2	1.0	1.6
Hearing difficulty/problems with background noise	1.1	1.8	3.6	0.1	-1.8	0.5	-1.3	-1.9
Hair/balding pattern: Pattern 2	1.0	1.3	4.1	2.0	-1.1	0.7	0.9	-0.3
Had menopause	0.1	0.1	0.3	-0.3	-0.5	0.1	-0.4	-0.3
Had other major operations	0.3	0.3	0.6	-0.6	-0.2	-0.0	-0.8	-0.8
Forced vital capacity (FVC)	1.3	5.2	11.2	-3.3	3.0	-2.2	0.0	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.2	-0.3	0.8	0.9	-1.5	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.8	-0.1	-0.9	0.1	0.5	0.6
Qualifications: None of the above	0.2	0.4	1.0	-0.2	-1.0	0.1	-0.9	-0.5
Financial difficulties in last 2 years	2.1	2.9	9.0	1.4	-3.0	0.9	1.3	0.8
Mouth/teeth dental problems	0.9	1.4	3.5	-0.0	1.9	0.1	-1.5	-1.0
Heart attack	0.1	0.2	0.6	0.2	-0.1	-0.4	-0.2	0.8
Allergy	0.6	1.4	4.7	0.6	-0.6	1.3	-2.2	-0.3
Pain all over the body in last month	2.2	2.3	5.2	-1.4	2.3	0.3	1.4	1.6
Diabetes (self-reported)	1.6	2.5	5.7	1.3	0.1	1.0	2.0	2.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.2	-0.3	0.2	-0.1	1.1	0.4
Medication: Ramipril	0.7	1.0	1.4	-0.9	0.7	-1.2	1.2	0.8
Medication: Simvastatin	0.2	0.3	0.8	0.9	-0.1	0.6	-0.1	-0.3
Fluid intelligence score	0.1	0.2	0.5	-0.0	-0.7	-0.0	-0.1	-0.7
Illnesses of siblings	0.7	1.0	2.7	0.7	-0.6	-0.2	-1.6	-1.2
Neuroticism score	0.9	1.9	3.8	-1.5	0.4	-2.0	-0.6	-1.7
Weight	0.1	0.5	1.6	1.3	-0.9	0.1	-0.3	0.3
Impedance of arm (right)	0.3	1.3	3.1	0.9	-1.0	-0.7	-1.8	-1.0
Arm fat percentage (right)	0.1	0.4	0.7	0.4	-0.7	-0.9	-0.1	-0.6
Trunk fat-free mass	0.1	0.6	0.9	1.0	0.3	0.6	-1.0	0.7
Hip circumference	0.1	0.3	1.2	-0.7	-0.3	-1.1	-0.0	-0.1
Time employed in main current job	0.9	1.0	3.0	-0.4	-0.8	-0.1	-1.7	-1.2
Alcohol intake versus 10 years previously	0.3	0.4	1.3	1.2	-0.5	0.2	-0.4	-0.4
Father’s age at death	1.0	1.4	2.9	-0.0	1.2	-0.0	1.7	1.6
Worrier / anxious feelings	0.9	1.7	3.9	-1.3	2.0	-1.1	-1.0	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.4	-0.8	1.6	-1.2	1.0	1.5
Falls in the last year	1.4	1.9	6.1	0.5	-0.1	0.4	1.8	2.5
Hair/balding pattern: Pattern 3	0.9	1.4	2.2	-1.5	1.2	-1.4	-0.9	-0.6
Number of live births	0.1	0.2	0.3	0.6	-0.4	-0.5	0.1	0.6
Forced expiratory volume in 1-second (FEV1)	2.2	7.5	16.2	-4.0	3.5	-2.6	0.7	-1.3
Pulse rate	2.3	3.9	13.4	0.3	0.4	0.8	3.7	2.3
Happiness	2.5	3.0	5.4	-2.3	0.3	-2.1	0.9	-2.1
Noisy workplace	2.0	2.5	5.2	0.1	1.9	0.7	1.7	2.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	0.6	-0.6	0.4	0.3	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	0.7	-1.3	-0.6	1.0	0.7
Mouth/teeth dental problems: Dentures	0.5	0.9	3.2	0.4	-1.8	-0.6	-0.2	-0.8
Asthma	1.6	3.1	6.9	2.2	-1.4	0.9	2.6	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.9	-1.4	1.1	-0.8	-0.5	-0.3
Medication: Cholesterol lowering	0.6	0.9	1.4	1.2	-0.7	0.6	0.9	1.1
Depression (self-reported)	0.8	0.9	2.5	-0.6	1.6	0.8	1.0	0.4
Medication: Lansoprazole	0.6	0.7	2.3	0.1	1.5	0.6	0.6	0.7
Prospective memory result	1.6	2.0	4.2	0.1	2.1	-0.1	-1.4	2.0
Lung cancer (father)	0.5	0.6	1.6	-0.6	1.3	0.4	-0.5	-0.6
Illnesses of mother	0.7	0.9	1.3	-0.9	0.8	-1.1	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	9.9	22.4	-4.7	3.5	-3.5	0.4	-1.6
Pulse wave Arterial Stiffness index	1.4	1.6	4.1	1.8	-2.0	-0.4	0.8	0.2
Impedance of arm (left)	0.3	1.5	4.0	0.5	-0.9	-0.6	-2.0	-1.4
Arm fat mass (right)	0.1	0.5	1.3	0.9	-1.1	-0.4	0.0	-0.4
Trunk predicted mass	0.1	0.5	1.1	0.9	0.3	0.5	-1.0	0.6
Standing height	0.4	4.2	11.1	2.8	-1.0	0.9	-3.3	0.1
Length of working week for main job	0.9	1.0	2.3	-0.3	-1.5	0.5	1.5	-0.4
Exposure to tobacco smoke at home	0.1	0.1	0.5	-0.7	-0.1	0.1	0.3	-0.4
Breastfed as a baby	0.2	0.3	1.3	0.1	-0.2	0.1	-1.1	0.3
Tense / ‘highly strung’	0.7	1.1	3.2	-0.5	-0.7	-1.8	-0.0	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.6	-0.3	-0.2	-0.7	1.2	-0.6
Hair/balding pattern: Pattern 4	1.0	2.4	10.1	0.2	0.2	1.3	-3.2	-0.4
Birth weight of first child	0.6	1.1	1.5	1.2	-1.2	0.9	-0.3	1.2
Peak expiratory flow (PEF)	0.8	1.8	3.6	-1.9	1.6	-0.9	1.4	0.2
Pulse wave reflection index	1.1	1.3	4.6	0.8	-0.8	-0.9	-2.1	0.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.0	-1.0	0.9	-1.0	0.3	-0.1
Loud music exposure frequency	0.7	0.8	2.9	-0.4	0.2	0.7	0.7	1.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.8	-1.1	0.1	-1.7	0.5	-1.0
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	6.2	0.1	0.2	1.6	2.5	1.6
Blood clot in the leg (DVT)	0.8	1.0	3.6	-0.6	1.9	-0.9	-0.3	0.3
Medication: Paracetamol	1.7	2.8	5.0	-1.3	0.3	-1.8	-2.0	-2.2
Headache pain in last month	0.7	1.2	3.4	0.3	-1.8	-1.2	0.7	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.6	-1.2	0.0	0.6	-0.1	-0.9
Glaucoma (self-reported)	1.0	1.2	2.0	1.3	0.2	1.4	1.4	0.0
Gout (self-reported)	0.1	0.1	0.4	0.7	-0.1	0.4	-0.1	-0.2
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.4	-0.8	-0.7	-1.2	0.8	-1.1
Medication: Amlodipine	0.2	0.3	0.5	-0.7	0.5	-0.5	-0.5	0.4
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	0.9	-0.4	-1.1	1.0	0.2
Birth weight	0.7	1.5	4.9	2.2	-0.4	1.4	-0.3	-0.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.7	0.2	-1.6	0.5	0.4	-0.5
High blood pressure (siblings)	0.1	0.2	0.6	0.2	-0.8	0.3	0.3	0.1
Forced vital capacity (FVC), Best measure	1.9	6.9	15.9	-4.0	2.8	-3.0	-0.1	-1.3
Body fat percentage	0.2	0.9	2.5	1.1	-1.6	-0.5	-0.5	-0.6
Leg fat percentage (right)	0.2	0.8	2.4	1.1	-1.5	0.1	-0.1	-0.3
Arm fat-free mass (right)	0.1	0.4	1.2	1.1	-0.5	0.6	-0.6	0.2
Exposure to tobacco smoke outside home	0.8	1.0	2.8	-0.7	-0.4	-1.7	0.9	0.9
Comparative body size at age 10	1.9	5.3	10.3	2.8	-0.4	3.2	0.8	2.8
Number of full brothers	0.6	0.8	1.7	-0.9	-0.1	-1.0	0.7	-1.3
Worry too long after embarrassment	0.6	1.0	1.8	-0.8	1.0	-1.3	-0.6	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.5	-0.2	0.5	0.7	1.2	0.8
Wheeze or whistling in the chest in last year	2.1	3.8	8.8	2.3	-0.4	1.4	3.0	1.7
Number of children fathered	1.0	1.1	2.3	1.0	1.5	1.0	0.7	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.1	0.2	-0.2	-0.4	-1.4	-0.7
Age at first live birth	0.1	0.2	0.3	0.5	0.4	0.1	-0.5	0.2
Pulse wave peak to peak time	1.2	1.4	3.2	-1.6	1.8	0.4	-1.0	-0.3
Health satisfaction	1.7	2.2	5.3	-1.1	-1.0	-2.3	-0.1	-1.9
Shortness of breath walking on level ground	1.1	1.3	2.4	1.6	-0.8	1.5	1.2	-0.3
Qualifications: College or University degree	1.3	4.1	6.8	-1.7	1.5	-1.4	-2.6	-2.6
Eye problems/disorders: None of the above	0.4	0.5	1.5	-0.6	-1.2	-0.4	0.3	-0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.1	0.1	-0.4	0.6	-0.2
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.4	0.6	0.4	0.6	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	2.4	1.1	-0.5	1.6	-0.6	0.6
Neck or shoulder pain in last month	0.5	0.8	1.8	0.3	-1.3	-0.9	0.8	-0.8
Medication: Blood pressure	0.2	0.4	1.0	0.9	0.1	-1.0	-0.6	-0.0
Angina (self-reported)	0.6	0.8	1.3	-1.1	0.8	-0.8	-0.9	-0.6
Migraine (self-reported)	0.2	0.2	0.6	0.6	-0.3	-0.1	-0.3	-0.8
Medication: Ibuprofen	0.3	0.4	0.9	-1.0	0.8	-0.4	-0.3	-0.4
Medication: Allopurinol	0.2	0.3	1.1	0.4	1.1	-0.5	-0.3	-0.0
Medication: Omeprazole	0.6	0.7	2.1	-0.4	0.8	-0.9	-1.5	-0.2
Medication: Seretide 50 evohaler	1.9	2.2	5.3	1.5	-2.3	0.9	1.6	-0.2
Mean time to correctly identify matches	0.3	0.6	2.8	0.5	-0.3	1.7	0.0	-0.1
Heart disease (mother)	1.0	1.2	2.0	1.2	-1.1	1.4	0.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.1	6.0	2.2	-2.4	2.3	1.3	1.7
Whole body fat mass	0.2	1.0	2.4	1.5	-1.5	-0.2	-0.6	-0.3
Leg fat mass (right)	0.2	0.6	1.5	1.2	-1.2	-0.0	-0.2	-0.2
Arm predicted mass (right)	0.1	0.3	0.8	0.9	-0.1	0.5	-0.2	0.5
Pulse rate, automated reading	0.9	3.0	11.2	-0.7	0.9	-1.4	3.3	0.6
Alcohol intake frequency.	1.4	3.3	8.0	2.6	-0.9	2.8	-0.6	0.8
Comparative height size at age 10	0.5	2.7	8.6	2.9	-0.6	1.5	-1.5	0.1
Number of full sisters	1.0	1.2	3.0	-0.3	0.2	-0.3	-1.7	-1.7
Suffer from ‘nerves’	0.8	1.2	2.9	-1.1	-0.1	-1.7	-0.1	-1.3
Overall health rating	0.4	0.8	2.3	0.1	0.4	-1.5	1.0	0.7
Chest pain or discomfort	0.7	1.1	2.9	-0.9	-0.7	-1.7	0.1	-1.1
Had major operations	1.0	1.2	4.0	-1.2	0.0	-2.0	0.5	-0.4
Age at last live birth	0.5	0.8	2.3	1.5	-0.8	0.8	-0.2	0.5
Family relationship satisfaction	1.5	1.8	2.8	-1.5	-0.4	-1.4	1.7	-1.3
Leg pain on walking	0.2	0.2	0.5	0.7	0.7	0.2	0.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	3.6	0.1	0.0	0.7	1.9	0.8
Commuting to job workplace: Car/motor vehicle	1.2	1.4	4.5	2.1	-1.0	1.1	0.0	-0.7
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	5.2	-2.3	2.0	-0.7	-0.7	-1.2
Medication: Aspirin	1.0	1.3	3.2	0.8	-0.2	0.8	1.8	1.3
Supplements: Vitamin C	1.0	1.2	2.1	-0.9	1.4	-0.9	-1.4	-0.0
Knee pain experienced in last month	0.1	0.2	0.5	0.5	-0.0	-0.3	0.5	0.7
Hypertension (Self-reported)	1.0	2.8	9.0	3.0	-2.1	0.4	-0.4	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.2	-0.8	1.8	-0.9	-0.3	0.3
Illnesses of father: Heart disease	0.9	1.2	2.8	0.9	-0.7	0.1	1.7	1.3
Illnesses of siblings: Diabetes	0.2	0.3	0.9	0.2	-0.2	0.3	0.9	0.7
Smoking status: Previous	0.7	1.1	3.2	-1.8	0.8	-1.1	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.4	-0.9	0.3	-1.4	-1.9	-1.1
Whole body fat-free mass	0.1	0.4	0.7	0.8	0.3	0.4	-0.7	0.7
Leg fat-free mass (right)	0.1	0.3	0.6	0.7	0.5	0.4	0.0	0.8
Arm fat percentage (left)	0.1	0.4	0.9	0.3	-0.6	-1.0	0.0	-0.7
Average weekly red wine intake	0.2	0.2	0.5	0.4	-0.6	-0.2	0.3	-0.7
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.2	-1.3	-0.3	-1.8	0.0	-0.7
Mood swings	0.1	0.3	0.5	-0.3	-0.3	-0.7	-0.5	-0.6
Loneliness, isolation	0.4	0.6	1.4	-0.2	-1.2	-0.8	-0.5	-0.7
Long-standing illness, disability or infirmity	2.7	4.2	8.9	1.9	-0.2	1.0	2.7	3.0
Ever had bowel cancer screening	0.8	0.9	2.0	0.3	-0.4	-0.7	-1.3	-1.4
Diabetes diagnosed by doctor	1.0	1.7	3.5	1.2	0.2	0.6	1.9	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.3	0.0	-0.8	-1.1	1.1	0.2
Friendships satisfaction	1.1	1.3	4.6	-1.2	0.1	-0.4	0.6	-2.1
Qualifications: nursing, teaching	0.1	0.2	0.6	0.8	-0.3	0.3	0.1	-0.1
Commuting to job workplace: Walk	0.7	0.8	1.6	-1.3	0.7	-0.6	1.2	0.0
Eye problems/disorders: Cataract	0.8	0.9	2.3	1.0	1.5	0.4	-0.8	0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.2	-0.6	-0.4	-0.6	0.1	1.5
Medication for cholesterol	0.4	0.7	1.3	-0.8	1.1	-0.9	0.7	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	6.4	-2.0	0.6	-2.5	0.2	-1.3
Back pain experienced in last month	0.9	1.4	3.5	0.9	0.0	1.5	0.3	1.9
Mineral and other dietary supplements	1.6	2.1	4.2	1.2	-1.9	0.4	2.0	-0.9
Breast cancer (self-reported)	1.5	1.8	6.2	1.2	-2.5	1.0	-0.6	0.0
Asthma (self-reported)	1.8	3.5	8.9	2.2	-1.5	0.6	3.0	1.1
Osteoporosis (self-reported)	0.7	0.9	2.6	-0.9	0.3	-1.6	-0.9	-0.4
Osteoarthritis (self-reported)	0.6	0.7	1.8	-0.2	1.3	-0.5	-0.7	-1.1
Medication: Aspirin	1.0	1.3	4.2	0.8	-0.2	0.8	2.0	0.9
Medication: Gliclazide	0.7	0.8	2.9	0.1	0.2	-0.8	1.7	0.6
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	-0.6	0.8	0.1	0.1	-0.5
Smoking status: Current	0.2	0.3	0.9	0.6	-0.5	0.0	0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.5	13.8	30.0	-5.5	4.3	-4.1	0.9	-1.5
Whole body water mass	0.1	0.4	0.9	0.9	0.2	0.5	-0.7	0.8
Leg predicted mass (right)	0.1	0.3	0.6	0.7	0.5	0.4	0.0	0.8
Arm fat mass (left)	0.1	0.4	0.9	0.7	-1.0	-0.6	-0.0	-0.6
Number of self-reported non-cancer illnesses	0.5	0.9	1.9	1.4	0.1	0.1	1.3	0.9
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.2	-0.8	0.5	-0.1	-0.6
Miserableness	0.4	0.6	2.6	-0.3	0.2	-0.6	1.6	0.1
Guilty feelings	0.8	1.1	3.2	-1.3	1.8	-0.9	-0.3	-0.3
Wears glasses or contact lenses	0.1	0.2	0.7	0.8	-0.3	-0.0	0.2	-0.1
Ever taken oral contraceptive pill	0.7	0.8	2.1	0.2	-0.5	0.5	1.5	1.2
Hearing aid user	0.2	0.3	1.2	-0.0	0.0	0.1	-0.3	1.1
Mother’s age at death	0.3	0.3	1.0	-1.0	0.5	-0.5	-0.4	0.0
Financial situation satisfaction	1.5	1.8	4.8	-0.1	-2.2	-1.2	1.1	-1.3
Tinnitus: Yes, now most or all of the time	1.0	1.1	1.9	0.7	-1.4	1.0	-1.0	-1.2
Commuting to job workplace: Public transport	0.8	1.0	1.9	-0.4	-1.3	-1.4	-0.7	-0.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	0.1	0.9	0.4	0.7	-0.2
Medication: Blood pressure	0.1	0.1	0.4	-0.1	-0.2	-0.1	-0.7	-0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.8	0.9	1.4	0.4	0.8	0.5
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.5	-1.4	2.1	-0.4	-0.8	1.4
High cholesterol (Self-reported)	1.3	2.3	5.3	1.8	-2.3	0.4	-1.3	-1.0
Medication: Bendroflumethiazide	0.7	1.0	3.5	0.5	0.1	0.0	-1.9	-1.1
Medication: Paracetamol	0.9	1.4	2.9	-0.5	-0.1	-1.5	-1.7	-1.2
Medication: Lisinopril	0.6	0.8	1.5	0.9	0.1	1.1	0.6	1.2
Medication: Atorvastatin	0.2	0.3	0.6	0.0	0.5	0.0	0.8	0.7
Illnesses of father: High blood pressure	0.3	0.3	1.2	0.5	0.1	1.1	-0.2	0.4
Alcohol drinker status: Never	1.9	2.3	3.8	1.3	0.1	1.6	1.8	1.9
Ever smoked	0.2	0.4	1.0	-0.9	-0.5	-1.0	-0.0	0.0
Basal metabolic rate	0.1	0.4	1.1	1.1	-0.2	0.4	-0.6	0.5
Leg fat percentage (left)	0.2	0.6	1.9	0.7	-1.4	-0.0	0.1	-0.5
Arm fat-free mass (left)	0.1	0.5	1.2	1.1	-0.6	0.6	-0.7	0.3
Number of operations (self-reported)	0.6	0.9	1.6	-0.9	-1.1	-0.9	0.1	-1.3
Average weekly beer plus cider intake	2.5	3.6	9.5	-1.3	0.3	-3.1	-1.2	-2.3
Irritability	0.2	0.4	1.2	0.6	-1.1	-0.6	0.4	-0.0
Risk taking	0.3	0.4	1.6	0.6	0.2	0.3	0.1	1.3
Ever had prostate specific antigen (PSA) test	1.3	1.6	3.2	-1.8	-0.9	-1.7	-0.7	-0.6
Fractured/broken bones in last 5 years	0.1	0.1	0.4	0.5	-0.6	-0.1	0.1	0.3
Age started oral contraceptive pill	0.6	0.7	1.7	-1.2	1.3	0.2	-0.2	0.8
Diastolic blood pressure, automated reading	0.6	1.7	4.8	-0.2	0.2	-1.7	-0.9	-2.2
Ever depressed for a whole week	0.9	1.1	3.5	0.3	0.7	-0.5	1.9	1.0
Unable to work because of sickness or disability	0.5	0.7	1.5	-0.9	0.5	-0.6	1.2	0.6
Commuting to job workplace: Cycle	0.8	1.0	2.3	-1.5	1.0	-0.5	-1.1	-0.5
Myopia	2.0	2.9	6.4	2.5	-1.4	2.5	0.5	0.5
Vascular/heart problems diagnosed by doctor	0.9	2.6	7.7	-2.8	2.2	-0.3	-0.0	-0.7
Cholesterol lowering medication	0.3	0.5	1.2	0.5	-0.2	0.7	-1.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	1.9	-0.8	0.9	-1.4	-1.3	-0.4
Pain experienced in last month	0.5	0.8	1.3	-1.0	-0.2	-0.7	-1.1	-1.2
Supplements: Calcium	0.7	0.8	3.2	0.4	0.4	0.8	-0.0	1.8
Basal cell carcinoma (self-reported)	1.6	1.9	2.9	1.2	-1.5	1.7	0.9	1.5
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.5	0.1	-0.3	-0.4	-0.1	0.7
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.6	-0.9	1.9	-1.1	-0.3	0.2
Heart disease (siblings)	0.3	0.3	0.8	-0.3	-0.0	0.2	0.9	0.8
Alcohol drinker status: Previous	1.5	1.7	5.2	0.6	0.4	2.3	-1.3	1.2
Pack years of smoking	0.1	0.2	0.4	0.4	0.4	0.6	-0.3	-0.0
Impedance of whole body	0.4	2.3	4.5	0.7	-1.6	-0.7	-2.1	-1.9
Leg fat mass (left)	0.1	0.5	1.3	1.0	-1.1	-0.1	-0.0	-0.3
Arm predicted mass (left)	0.1	0.3	0.6	0.8	-0.2	0.4	-0.8	0.1