TWAS hub - LLGL2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0710	0.0260	1.5e-04	0.011	0.027	0.017	0.026	0.016	1.4e-02	0.00027	2.9e-03	0.00037	4.1e-03
2	GTEx	Artery Aorta	0.2320	0.0680	1.1e-05	0.055	NA	0.116	NA	0.101	5.5e-04	NA	6.4e-07	NA	3.3e-06
3	GTEx	Artery Tibial	0.1485	0.0520	1.0e-04	0.040	NA	0.093	NA	0.074	4.0e-04	NA	8.8e-08	NA	2.0e-06
4	GTEx	Breast Mammary Tissue (Female)	0.1091	0.0726	9.2e-02	-0.007	NA	0.002	NA	0.025	6.1e-01	NA	2.7e-01	NA	6.0e-02
5	GTEx	Esophagus Muscularis	0.2260	0.0710	1.4e-04	0.174	NA	0.162	NA	0.168	9.5e-11	NA	4.6e-10	NA	2.0e-10
6	GTEx	Heart Left Ventricle	0.2275	0.0670	1.3e-04	0.092	NA	0.098	NA	0.107	1.3e-05	NA	7.2e-06	NA	2.5e-06
7	GTEx	Muscle Skeletal	0.2168	0.0681	1.3e-04	0.076	NA	0.066	NA	0.078	6.7e-08	NA	4.2e-07	NA	4.3e-08
8	GTEx	Nerve Tibial	0.2104	0.0728	1.3e-03	0.054	NA	0.068	NA	0.070	1.1e-04	NA	1.5e-05	NA	1.1e-05
9	GTEx	Testis	0.1730	0.0720	1.3e-03	0.054	NA	0.129	NA	0.125	2.1e-03	NA	2.4e-06	NA	3.7e-06
10	GTEx	Thyroid	0.0840	0.0400	8.1e-03	0.035	NA	0.014	NA	0.040	1.0e-03	NA	2.6e-02	NA	4.7e-04
11	METSIM	Adipose	0.0964	0.0417	3.8e-03	-0.002	0.010	0.027	0.015	-0.002	8.5e-01	0.00960	5.9e-05	0.00210	7.3e-01
12	NTR	Blood	0.0148	0.0075	2.0e-02	0.002	0.001	0.000	0.004	0.000	6.3e-02	0.10000	2.3e-01	0.02000	3.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.3	17.5	36.1	3.0	3.0	1.8	-0.9	6.0	6.0	5.9	4.8	-4.3	5.2	3.4	1.2
Lung FVC	4.7	23.9	48.3	5.7	1.7	2.8	-2.3	6.5	7.0	6.7	5.0	-6.8	5.3	1.5	0.6
Lung FEV1/FVC ratio	3.6	18.5	46.2	3.0	3.2	-0.0	-0.3	6.3	6.8	6.4	4.1	-2.1	5.2	4.1	3.2
Happiness	3.5	4.2	8.6	1.6	1.5	2.0	-1.6	2.9	2.9	2.7	2.7	-1.2	2.0	1.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	3.4	10.8	22.2	2.5	2.0	2.0	-1.6	4.5	4.6	4.7	4.1	-3.5	3.8	2.3	-0.9
Hayfever, allergic rhinitis or eczema	3.2	7.0	16.6	1.0	0.5	-0.8	-1.8	4.0	3.6	3.6	2.8	-2.3	4.1	1.5	2.2
Forced expiratory volume in 1-second (FEV1)	2.9	9.6	21.3	1.7	1.9	1.0	-1.1	4.3	4.5	4.6	3.3	-3.2	4.3	2.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	8.3	-0.3	2.9	0.2	-1.6	2.1	1.6	1.6	2.0	0.2	2.7	2.9	0.4
Coronary Artery Disease (CAD)	2.8	3.3	12.5	-0.1	2.5	-1.5	1.3	2.5	2.0	2.1	1.5	-0.1	3.5	0.7	0.2
Taking other prescription medications	2.8	4.3	10.7	-0.7	2.1	-2.1	-2.6	2.7	1.9	2.0	1.4	0.7	3.3	2.0	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	15.0	0.1	2.8	-1.6	-0.2	2.3	1.3	1.3	-0.1	0.5	2.3	3.9	0.3
Diabetes (father)	2.7	3.3	8.7	-1.5	-2.9	-0.1	-1.6	-1.8	-1.9	-2.0	-2.1	0.5	-2.2	-1.9	-1.7
Qualifications: CSEs or equivalent	2.7	3.5	6.6	-2.0	-0.6	-0.9	1.2	-2.3	-2.5	-2.4	-1.7	2.6	-2.2	-2.1	-0.1
High cholesterol (Self-reported)	2.7	4.9	19.0	-2.4	1.6	-1.5	4.4	-2.5	-2.5	-2.4	-1.1	2.2	-1.7	-1.2	0.7
Number of incorrect matches in round	2.6	4.3	12.7	-0.5	-0.1	-0.9	1.9	-3.1	-3.3	-3.6	-1.5	1.4	-2.7	-1.7	0.0
Suffer from ‘nerves’	2.4	3.7	8.9	-0.7	3.0	-0.3	2.4	1.8	1.7	1.6	2.4	1.5	2.2	2.6	1.1
Family relationship satisfaction	2.4	3.0	5.6	1.1	0.1	1.9	-0.6	2.4	2.3	2.3	2.0	-2.2	2.0	1.3	0.3
Ever used hormone-replacement therapy (HRT)	2.3	2.9	5.3	1.1	1.8	2.3	0.7	1.6	1.6	1.9	1.2	-2.2	1.5	2.0	-1.8
Breast cancer (self-reported)	2.2	2.6	6.8	-1.7	-0.2	-0.2	1.8	-2.2	-2.2	-2.6	-1.5	0.9	-2.1	-1.0	-0.3
Allergy or Eczema	2.1	5.5	16.2	0.9	0.6	-0.8	-1.3	3.5	2.9	3.3	1.7	-2.6	4.0	1.6	1.5
Respiratory disease	2.1	4.6	21.7	-1.5	-3.4	-0.9	-4.7	-0.7	-1.6	-1.1	-2.6	-1.0	-0.6	-2.4	0.6
Allergy	2.1	4.9	12.1	0.2	0.4	1.6	3.5	-3.0	-2.3	-2.5	-1.5	1.7	-3.5	-1.1	-2.3
Pulse rate	2.1	3.5	9.4	0.8	-0.3	-1.8	1.1	2.8	1.7	2.3	0.1	-1.8	2.6	-0.8	3.1
Medication: Lansoprazole	2.1	2.3	8.7	-2.0	1.2	-1.7	-1.0	1.2	0.3	0.9	-1.2	0.9	2.9	1.6	1.6
Health satisfaction	2.1	2.7	8.4	-0.4	2.4	0.1	-2.9	0.7	0.6	0.3	2.1	2.4	0.3	2.5	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	5.6	-2.3	-2.0	-0.8	-0.2	-1.7	-2.4	-1.9	-2.2	0.6	-1.3	-0.9	-0.3
Waist Hip Ratio (WHR)	2.0	8.9	25.0	-5.0	-1.3	-0.1	-0.1	-3.5	-3.0	-2.9	-3.7	4.6	-2.8	0.3	-2.9
Alcohol intake frequency.	2.0	4.5	12.5	-3.3	-0.7	-0.6	1.5	-2.3	-2.6	-2.4	-3.5	2.6	-1.4	-0.7	-0.8
Alcohol drinker status: Previous	2.0	2.3	7.6	-1.3	0.2	-0.5	-0.5	-1.5	-2.0	-1.7	-2.8	2.0	-1.1	-1.7	-0.4
LDL Cholesterol	1.8	2.8	16.0	0.3	1.8	0.9	4.0	0.8	1.7	1.0	2.1	-0.3	-0.1	1.4	-1.6
Noisy workplace	1.8	2.3	7.2	-0.6	0.7	-2.0	0.3	1.9	1.2	1.8	-0.6	-0.6	2.7	0.3	2.4
Pulse rate, automated reading	1.8	5.9	14.4	1.4	1.6	-1.2	1.1	3.8	3.4	3.8	2.0	-1.4	3.6	0.3	2.0
Long-standing illness, disability or infirmity	1.8	2.7	10.1	-3.1	-0.7	-3.2	-2.2	0.7	-0.1	0.3	-1.2	1.3	1.7	0.9	0.6
Ulcerative Colitis (UC)	1.7	3.2	7.0	-1.5	1.0	-0.4	2.2	-2.7	-2.3	-2.1	-0.6	2.4	-1.7	0.9	-1.9
Exposure to tobacco smoke outside home	1.7	2.3	9.4	1.5	-1.6	-1.4	-3.1	1.2	1.1	1.2	1.2	-1.9	1.2	-0.0	0.8
Comparative body size at age 10	1.7	4.7	10.8	-1.9	-2.7	-3.2	-1.4	-2.0	-2.0	-1.8	-2.9	-0.2	-0.9	-3.3	1.6
Shortness of breath walking on level ground	1.7	2.0	10.2	-2.7	0.5	-1.2	-3.2	-0.2	-0.3	-0.4	-0.3	2.1	-0.4	-0.2	-0.0
Peak expiratory flow (PEF)	1.6	3.8	9.0	1.0	-0.1	-0.8	-2.7	2.7	2.4	2.3	1.4	-2.1	3.0	1.3	1.0
Forced vital capacity (FVC), Best measure	1.6	6.0	10.7	2.1	1.5	1.8	-1.5	3.2	3.1	3.2	3.3	-3.1	2.6	1.1	-1.2
Commuting to job workplace: Walk	1.6	1.7	5.1	1.0	0.2	1.1	-0.0	1.2	1.1	1.4	1.1	-2.3	0.8	-1.5	2.1
Worry (Nagel 2018)	1.5	3.1	15.4	-1.1	3.9	0.6	1.7	0.2	0.1	0.2	2.2	2.8	1.0	1.4	-1.0
Ever had hysterectomy (womb removed)	1.5	1.7	5.0	0.2	0.9	1.3	-0.8	1.5	1.5	1.8	0.2	-2.2	2.1	0.6	0.2
Fed-up feelings	1.5	2.8	8.6	2.9	1.0	1.9	-0.1	1.8	1.8	1.9	1.7	-1.2	1.1	2.1	-0.2
Pain all over the body in last month	1.5	1.6	3.7	0.1	-0.8	0.0	-1.8	1.4	1.2	1.6	0.2	-1.2	1.9	1.8	-1.0
Pulse wave reflection index	1.5	1.9	4.8	-1.4	0.5	0.8	-0.7	-1.9	-1.5	-1.9	-0.0	2.2	-2.0	-1.0	-0.7
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.8	-2.0	1.5	-2.2	0.4	1.2	0.9	1.4	-0.6	1.0	2.1	0.4	1.2
Myopia	1.5	2.1	5.5	-1.0	-1.6	-0.5	0.8	-1.8	-1.9	-1.8	-2.4	0.3	-1.8	-1.4	-0.2
Neuroticism (Nagel 2018)	1.4	3.4	15.4	0.4	3.9	0.9	0.1	1.6	1.4	1.3	2.5	1.6	1.6	2.5	-0.3
Lupus	1.4	2.1	7.3	-2.0	-2.4	-0.8	-1.1	0.0	-0.2	0.3	-2.4	0.7	-0.3	-2.7	0.1
Impedance of leg (right)	1.4	6.6	14.5	-1.1	0.2	1.8	2.6	-3.3	-2.9	-3.3	-0.6	3.8	-3.5	0.0	-3.2
High blood pressure	1.4	3.9	9.5	-1.7	-0.0	-1.1	3.1	-2.8	-2.5	-2.4	-1.0	2.3	-2.4	0.2	-1.2
High blood pressure (mother)	1.4	2.0	5.8	-1.1	-0.5	0.8	1.0	-2.2	-2.1	-1.6	-2.4	0.5	-1.3	-0.0	-1.1
Hair/balding pattern: Pattern 4	1.4	3.4	8.2	-0.9	0.4	0.4	1.5	-2.9	-2.6	-2.7	-1.9	2.2	-1.8	-0.1	-1.7
Comparative height size at age 10	1.4	7.5	21.8	-4.7	-0.0	-1.4	-0.2	-2.9	-3.2	-2.7	-2.8	3.8	-2.4	-2.6	-2.5
Leg pain on walking	1.4	1.8	5.5	-1.8	1.6	-2.4	-0.2	1.1	1.3	0.9	0.0	1.7	1.2	1.3	0.5
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.6	2.1	1.0	0.7	1.1	1.1	1.6	1.4	0.4	-2.1	1.3	1.0	0.3
Miserableness	1.4	2.5	9.8	0.1	0.8	-1.5	-0.9	1.5	1.1	1.6	1.0	-0.3	2.7	3.1	1.5
Guilty feelings	1.4	2.1	5.7	-0.6	1.9	-0.6	-0.7	1.4	1.1	1.4	2.0	1.0	2.4	1.2	1.7
Financial situation satisfaction	1.4	1.8	6.5	2.5	-0.9	1.1	-1.9	1.2	1.5	0.9	1.4	-0.8	-0.3	1.4	0.4
Ever had prostate specific antigen (PSA) test	1.4	1.6	7.8	2.8	0.2	1.3	-0.8	-0.0	-0.1	-0.3	1.1	-2.2	-0.1	1.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	8.6	-0.2	0.2	-0.5	-2.9	1.3	1.2	1.5	1.0	-0.2	1.7	1.8	-0.2
Pack years adult smoking proportion	1.3	2.0	11.5	-1.2	-1.5	-0.3	-3.4	-1.2	-1.6	-0.8	-1.6	0.8	-0.1	0.5	-0.9
Maternal smoking around birth	1.3	1.8	6.3	0.9	-0.0	-0.5	-1.0	1.6	2.1	1.8	0.1	-1.2	1.2	2.5	0.7
Asthma	1.3	2.6	12.2	-2.2	-2.1	-1.4	-3.5	-0.0	-1.0	-0.3	-1.8	-0.2	0.3	-1.3	1.3
Standing height	1.3	12.9	23.2	-4.4	-0.5	0.2	0.0	-4.4	-4.7	-4.3	-3.1	4.2	-4.4	-2.5	-4.8
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	5.2	1.5	-1.6	0.4	-1.8	1.4	0.9	1.0	-0.7	-2.3	0.5	-1.0	1.3
Wheeze or whistling in the chest in last year	1.3	2.3	12.7	-1.4	-2.2	-1.7	-3.6	0.3	-0.7	-0.0	-1.9	-0.0	0.5	-0.6	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	6.4	1.1	0.5	2.2	0.4	-1.2	-0.7	-1.3	0.6	0.1	-2.5	-1.2	-0.4
Asthma (self-reported)	1.3	2.5	13.2	-1.8	-2.1	-1.3	-3.6	0.2	-0.7	-0.2	-1.5	-0.4	0.3	-1.4	1.7
Medication: Bendroflumethiazide	1.3	2.0	5.3	-1.2	1.2	1.7	0.1	-1.2	-0.6	-1.0	-0.0	2.0	-1.2	2.3	-2.3
Unable to work because of sickness or disability	1.3	1.7	8.7	-0.1	0.1	-1.4	-3.0	1.3	1.1	1.3	0.5	-0.4	1.8	1.1	0.2
Bipolar Disorder (2018)	1.2	1.9	6.2	0.2	0.6	2.5	-2.1	0.4	0.9	0.7	1.4	-0.7	-0.4	1.9	-1.9
Smoking Status	1.2	2.8	7.0	2.5	1.0	0.3	-2.6	1.8	1.8	1.8	1.4	-1.5	1.6	0.3	1.4
Forced vital capacity (FVC)	1.2	4.7	9.7	1.1	1.0	0.9	-1.3	2.9	2.9	3.1	2.6	-2.8	3.0	1.2	-0.5
Depression (self-reported)	1.2	1.4	3.4	0.6	0.3	0.3	-0.4	1.8	1.5	1.7	0.2	-1.5	1.7	1.3	0.7
Prospective memory result	1.2	1.5	6.3	-1.3	2.1	-0.6	0.9	-0.5	-0.9	-0.9	-1.0	2.5	-0.2	-1.0	0.6
Birth weight of first child	1.2	2.1	5.0	-1.3	-0.5	-2.0	0.2	-1.5	-1.8	-2.2	-0.4	1.6	-1.4	-1.6	1.1
Blood clot in the leg (DVT)	1.2	1.5	8.0	-0.4	0.3	-0.6	-2.8	1.0	0.8	1.2	0.6	-0.1	1.7	1.8	-0.3
Number of full brothers	1.2	1.5	4.0	0.3	0.8	1.3	0.3	1.6	1.8	2.0	1.5	-1.1	1.2	0.9	0.3
Number of full sisters	1.2	1.5	4.3	-0.9	1.5	2.1	-1.3	-0.4	-0.5	-0.6	-0.4	1.1	-0.8	1.5	-1.9
Hypertension (Self-reported)	1.2	3.2	7.6	-1.5	0.2	-0.7	2.7	-2.6	-2.2	-2.1	-0.8	2.1	-2.3	0.2	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	5.0	-0.8	1.7	-0.5	-1.7	0.9	0.7	0.8	0.9	1.1	1.2	2.2	-0.4
Heart disease (siblings)	1.2	1.5	4.1	-2.0	1.4	-1.2	2.0	0.9	0.6	1.0	0.3	0.7	1.4	0.8	0.9
Depressed Affect (Nagel 2018)	1.1	2.3	10.6	1.7	2.1	1.1	-0.6	1.0	0.9	1.1	1.5	0.2	1.4	3.3	-0.3
Reaction Time	1.1	2.1	6.3	0.0	-0.1	-0.5	-1.1	1.5	1.6	1.3	-0.7	-1.5	2.5	2.1	1.8
Rheumatoid Arthritis	1.1	1.6	5.5	0.2	1.0	-1.5	-1.1	1.4	1.0	1.6	-0.7	0.5	2.3	1.1	1.0
Height	1.1	20.5	43.8	-6.6	-1.3	-0.6	-0.4	-5.4	-5.8	-5.1	-5.1	5.3	-4.6	-2.5	-5.5
Vitamin and mineral supplements	1.1	1.5	7.4	-0.5	-2.2	-0.5	0.1	0.3	0.4	0.5	0.2	-2.0	0.7	-0.6	2.7
Stomach or abdominal pain in last month	1.1	1.3	4.3	-0.2	1.3	-1.0	-2.1	1.1	0.7	1.1	0.8	1.1	1.7	1.1	0.3
Medication: Atenolol	1.1	1.4	3.2	0.1	1.6	0.7	1.6	-1.5	-1.1	-1.3	-0.0	1.8	-1.2	0.6	-0.7
Worrier / anxious feelings	1.1	2.0	12.2	-0.5	3.5	-0.2	1.3	0.8	0.6	1.0	0.9	1.7	1.7	1.1	-0.4
Falls in the last year	1.1	1.5	8.3	-1.3	0.6	-2.9	-1.3	1.1	0.6	0.5	0.6	0.8	1.4	1.0	0.5
Pulse wave Arterial Stiffness index	1.1	1.3	6.2	-2.5	0.3	-1.5	0.5	-1.0	-1.0	-1.0	-0.1	1.9	-0.5	-0.4	0.5
Number of children fathered	1.1	1.3	5.2	-0.7	-1.1	0.6	-2.3	-0.5	-0.9	-0.5	-1.0	-0.6	-0.8	-2.2	-0.2
Medication for pain relief, constipation, heartburn	1.1	2.0	5.9	-1.0	-1.5	0.1	0.7	-1.3	-1.2	-1.6	-1.8	-0.5	-2.1	-2.4	-0.3
Had major operations	1.1	1.3	5.0	-0.3	0.6	-0.8	1.3	1.4	1.4	1.2	2.2	-0.9	0.9	0.9	-0.2
Supplements: Vitamin C	1.1	1.3	4.7	-1.4	2.2	-0.5	-0.6	0.3	0.1	-0.1	-0.4	1.5	0.3	2.0	-1.4
Pack years of smoking	1.1	1.6	11.8	-0.9	-1.3	-0.2	-3.4	-0.8	-1.1	-0.4	-1.3	0.6	0.2	0.7	-1.0
Hypothyroidism (self reported)	1.0	2.4	18.0	1.4	0.4	-0.2	-4.2	1.0	0.7	0.8	1.2	0.8	1.4	1.4	0.8
Neuroticism	1.0	2.3	8.9	0.3	2.7	0.3	0.0	0.9	0.6	0.9	1.8	1.4	2.0	3.0	-0.5
Serious illness, injury or assault to yourself	1.0	1.2	4.3	-1.6	0.2	-1.6	-0.8	-0.7	-1.4	-1.1	-0.7	2.1	-0.3	0.0	0.4
Nervous feelings	1.0	1.9	6.5	-1.2	2.5	-1.6	1.0	0.4	0.1	0.1	1.6	2.2	1.0	1.8	0.3
Hearing difficulty/problems with background noise	1.0	1.7	8.1	-0.8	-0.7	1.2	-2.8	-1.1	-0.5	-0.6	-0.0	0.7	-1.1	1.4	-2.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	4.6	-0.1	0.1	-1.6	-1.2	1.1	0.7	0.8	0.5	-0.4	2.0	-0.3	2.1
Medication: Ramipril	1.0	1.3	4.0	1.0	-0.2	1.4	0.2	0.9	0.8	1.2	1.0	-2.0	0.6	1.6	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	5.2	-0.2	-1.7	-1.4	-1.5	0.2	0.1	0.3	0.9	-0.8	-0.1	-2.3	0.7
Length of working week for main job	1.0	1.2	5.9	2.4	-0.7	-0.8	-0.5	0.4	0.4	0.3	1.2	-1.7	0.3	-0.3	1.3
Tense / ‘highly strung’	1.0	1.6	6.7	-0.6	1.9	-0.2	0.2	0.7	0.9	0.6	2.6	1.4	1.0	2.0	0.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.3	0.7	1.3	-0.9	-1.4	1.4	1.0	1.1	0.5	-0.0	1.8	1.1	0.7
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.6	0.9	0.5	0.1	0.9	1.7	1.6	1.5	1.9	-1.5	1.6	-0.2	1.2
Medication: Paracetamol	1.0	1.7	5.3	1.3	1.7	2.0	-0.2	-0.4	0.1	-0.1	1.0	0.8	-0.3	2.3	-2.1
Glaucoma (self-reported)	1.0	1.2	6.3	-1.3	-0.1	0.1	1.7	-0.5	-0.7	-0.0	-0.7	0.2	0.5	-2.5	1.4
Medication: Omeprazole	1.0	1.2	3.9	-1.2	1.8	-0.5	-2.0	0.7	0.3	0.4	0.8	1.4	0.8	1.2	-0.0
Ever had bowel cancer screening	1.0	1.2	3.5	-0.4	1.5	0.3	0.2	-1.1	-0.6	-1.0	-0.2	1.9	-1.0	1.3	-1.7
Average weekly champagne plus white wine intake	1.0	1.4	4.1	0.6	-1.4	1.9	0.9	-1.0	-0.8	-0.7	-0.8	-0.6	-1.5	-2.0	-0.8
Basal cell carcinoma (self-reported)	1.0	1.2	4.8	0.0	-0.5	-2.2	1.2	-1.1	-1.5	-1.2	-1.6	0.6	0.0	0.3	0.7
Neuroticism (2016)	0.9	1.3	3.3	0.8	1.8	0.9	0.3	1.2	1.2	1.1	1.8	0.8	0.7	1.2	1.2
Heel T-Score	0.9	7.2	15.3	3.3	-2.5	3.7	-1.3	-3.0	-1.7	-1.9	-1.6	-2.1	-3.9	-2.0	-3.6
Sensitivity / hurt feelings	0.9	1.5	3.9	-0.3	2.0	0.3	0.4	1.8	1.5	1.8	0.1	0.4	1.8	1.1	0.5
Severe depression (siblings)	0.9	1.0	3.7	-0.2	-0.8	-1.9	-1.1	0.8	0.7	0.7	-0.1	-0.4	1.2	1.9	0.3
Multivitamins +/- minerals	0.9	1.1	4.2	0.6	0.9	-0.3	0.2	-1.0	-1.4	-1.1	-0.6	1.8	-0.6	0.4	-2.0
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.3	0.4	-1.2	-2.1	-1.6	-0.5	-0.8	-0.8	0.4	0.6	-0.5	-1.5	0.9
Past tobacco smoking	0.9	1.6	4.2	-2.1	-0.8	-0.7	0.8	-1.4	-1.5	-1.3	-1.6	1.5	-1.0	-1.1	-0.6
Alcohol usually taken with meals	0.9	1.5	3.6	-1.9	-1.7	-1.1	0.8	0.0	-0.4	0.3	-1.6	-1.8	1.2	-1.5	-0.2
Medication: Simvastatin	0.9	1.3	5.3	-1.6	1.7	-0.8	2.3	-0.7	-0.7	-0.3	-0.2	1.3	0.5	-0.4	1.0
Neuroticism score	0.9	1.9	7.1	-0.0	2.7	-0.1	0.8	1.0	0.6	0.8	2.1	1.1	1.7	1.9	0.7
Hair/balding pattern: Pattern 3	0.9	1.3	3.3	1.0	1.8	-0.2	0.7	1.2	1.4	1.4	1.6	-0.3	1.5	1.0	0.1
Number of live births	0.9	1.3	5.2	-1.8	-1.5	-0.6	-0.9	0.4	0.3	0.1	0.5	-1.1	-0.1	-2.3	1.5
Loud music exposure frequency	0.9	1.0	3.4	0.0	-0.0	-1.6	-0.5	0.9	0.1	0.4	-0.7	-1.1	1.6	-0.7	1.8
Gout (self-reported)	0.9	1.2	4.0	-0.9	-0.5	1.0	-1.2	-0.8	-0.6	-0.9	-0.4	0.2	-1.9	-0.9	-2.0
Worry too long after embarrassment	0.9	1.6	5.0	-0.4	2.2	0.1	0.6	1.7	1.6	1.6	1.5	0.4	1.0	1.2	-0.4
Pulse wave peak to peak time	0.9	1.1	4.9	2.2	-0.4	1.6	-0.4	0.7	0.7	0.7	-0.1	-1.7	0.2	0.4	-1.0
Neck or shoulder pain in last month	0.9	1.3	2.4	-0.8	1.6	-0.4	-0.8	1.5	1.2	1.4	0.7	0.8	1.4	0.9	1.5
Migraine (self-reported)	0.9	1.1	2.1	-1.1	1.4	-0.1	1.1	-1.0	-1.3	-1.0	-0.5	1.4	-0.3	1.1	-1.4
Medication: Seretide 50 evohaler	0.9	1.1	5.2	0.1	-1.9	-0.5	-2.3	-0.3	-0.2	-0.3	-1.4	-1.0	0.1	0.5	0.5
Overall health rating	0.9	2.0	3.5	-1.4	1.6	-1.2	-1.9	1.3	1.0	1.1	1.5	1.7	1.5	1.7	0.7
Friendships satisfaction	0.9	1.1	2.5	1.0	0.8	1.1	-0.7	1.5	1.1	1.4	0.8	-0.7	1.6	0.8	0.6
Illnesses of father: None of the above (group 1)	0.9	1.2	4.0	-0.8	1.8	0.5	1.2	0.4	0.6	0.5	0.6	1.4	0.9	2.0	-0.5
Number of operations (self-reported)	0.9	1.3	3.6	-0.2	1.6	-0.9	-0.9	1.1	1.2	1.2	1.9	-0.7	1.4	1.0	0.4
Average weekly beer plus cider intake	0.9	1.3	3.7	0.3	1.4	1.1	-0.5	0.8	1.0	0.8	1.7	1.1	-1.3	0.5	-1.9
Vascular/heart problems diagnosed by doctor	0.9	2.6	7.7	1.2	-0.5	0.7	-2.8	2.2	1.9	1.9	0.5	-2.0	2.1	-0.5	0.7
Alzheimer’s Disease (in mother)	0.8	0.9	3.4	1.8	-1.1	-1.6	-0.4	0.6	0.3	0.2	0.0	-0.1	-0.3	-1.4	1.0
Alzheimer’s Disease (including proxy)	0.8	1.1	6.5	2.5	-0.7	-0.3	-1.2	1.0	0.7	0.8	0.5	-0.9	-0.1	-1.2	-0.1
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.4	1.6	-1.6	1.0	0.2	1.5	2.1	1.4	1.1	-2.5	0.7	0.5	0.5
Breast Cancer	0.8	1.9	3.7	1.7	1.2	1.2	1.9	1.5	1.1	1.5	0.5	-1.9	1.9	-0.7	-0.5
Mean Putamen Volume	0.8	1.0	4.4	-0.4	2.1	-1.1	0.4	-0.2	-0.5	-0.2	-1.4	0.8	0.6	-1.5	-0.2
HbA1C	0.8	0.9	3.0	-1.4	-0.2	-1.7	-0.9	0.6	0.6	0.9	-0.2	-0.8	1.4	0.4	-0.6
HDL Cholesterol	0.8	1.4	4.6	-0.4	-1.6	-0.3	-1.7	-1.1	-1.6	-1.2	-2.2	-0.5	-0.3	-0.5	-0.5
Ulcerative Colitis	0.8	1.2	3.5	-0.6	1.4	-0.6	0.9	-0.9	-1.1	-1.0	-0.9	1.3	0.0	1.9	-1.4
Blood Red Count	0.8	8.1	22.2	-1.7	-0.5	2.1	0.1	-4.7	-3.6	-3.9	-2.0	3.1	-3.9	-0.3	-3.4
Chronotype (morning person)	0.8	1.7	4.9	-2.1	0.9	-0.8	1.0	-1.4	-1.7	-1.5	-0.1	2.2	-0.6	-1.0	0.5
Hand grip strength (left)	0.8	2.0	5.7	-1.5	-1.5	-1.0	1.4	-0.8	-1.5	-0.8	-2.4	-0.2	-0.6	-2.2	1.4
Medication: Co-codamol	0.8	0.9	4.4	-0.6	0.9	0.7	-1.5	0.5	0.4	0.5	0.4	0.1	1.2	2.1	-0.2
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.5	0.9	-0.8	0.3	-1.4	0.9	0.9	0.9	0.4	-1.9	0.9	0.7	0.4
Supplements: Glucosamine	0.8	1.0	3.3	-0.7	1.6	-0.6	-0.1	0.2	0.0	0.4	-0.0	0.7	1.4	1.8	-1.8
Medication: Levothyroxine sodium	0.8	1.3	10.7	0.8	-0.4	-0.6	-3.3	0.0	-0.0	0.1	1.0	1.2	0.5	0.7	-0.2
Impedance of leg (left)	0.8	4.0	7.5	-0.5	0.0	2.6	2.2	-2.4	-2.1	-2.5	-0.1	2.6	-2.7	0.2	-2.4
Diabetes (self-reported)	0.8	1.2	7.9	-0.3	-0.5	-2.8	-0.5	0.1	-0.6	-0.3	-1.5	0.1	0.6	-1.0	1.1
Impedance of arm (right)	0.8	3.6	8.6	-2.3	-0.1	0.7	-0.4	-2.4	-2.1	-2.4	-0.2	2.9	-2.2	0.1	-2.9
Time employed in main current job	0.8	0.9	2.4	1.1	-0.2	1.3	-0.3	-0.6	-0.1	-0.4	0.7	0.8	-1.3	1.6	-1.2
Alcohol intake versus 10 years previously	0.8	1.2	4.6	-1.3	-0.8	0.6	0.5	-1.2	-0.9	-0.7	-1.3	0.5	-1.3	-0.2	-2.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	5.3	-0.2	0.7	-0.1	-2.1	1.1	0.7	1.0	0.6	0.5	1.0	2.3	-0.9
Medication: Cholesterol lowering	0.8	1.3	5.5	-1.0	0.6	-2.1	2.4	-0.5	-0.7	-0.3	-0.1	0.5	0.1	-0.9	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.2	0.2	0.2	-1.5	-0.7	1.4	1.1	1.3	1.4	-0.1	1.8	0.2	1.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.8	1.1	-1.0	1.4	-1.9	1.1	1.1	0.8	-0.3	-1.5	0.6	1.1	-0.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	10.8	1.1	0.2	0.3	-3.3	0.9	0.7	0.8	1.0	0.6	1.2	1.6	-0.4
Eye problems/disorders: None of the above	0.8	0.9	5.4	0.9	-0.3	-0.3	0.4	0.4	0.9	0.5	0.6	-1.4	0.9	2.3	0.2
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.8	1.6	-0.8	0.9	-0.2	0.5	0.8	0.7	0.4	-1.0	-0.2	1.9	-1.1
Chest pain or discomfort	0.8	1.2	4.6	0.3	1.7	-0.4	-0.6	1.1	0.9	0.8	2.1	0.6	0.8	1.6	0.4
Knee pain experienced in last month	0.8	1.3	6.5	-0.6	0.4	-2.5	0.2	0.9	0.9	1.1	-0.0	1.0	1.9	0.6	0.8
Illnesses of father: Heart disease	0.8	1.1	6.0	-0.6	0.2	-2.5	0.9	0.3	-0.1	0.3	1.0	0.5	0.4	-0.4	2.1
Smoking status: Previous	0.8	1.1	2.8	1.7	1.0	0.5	0.3	1.3	1.5	1.1	1.2	-1.1	0.9	0.9	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.5	-0.7	-1.0	-0.3	-1.6	0.5	0.9	0.4	1.5	-0.6	-0.2	1.2	0.2
Medication: Lisinopril	0.8	1.1	2.3	-1.5	-0.2	-0.9	0.5	-1.0	-1.2	-1.1	-0.5	1.4	-0.3	-1.5	1.1
Irritability	0.8	1.4	6.5	0.2	0.4	-1.7	-1.4	0.3	0.0	-0.4	1.3	1.7	0.2	0.4	2.6
Cholesterol lowering medication	0.8	1.1	3.7	-1.6	1.5	-0.5	1.9	-0.6	-0.9	-0.6	-1.2	1.1	0.2	0.3	0.7
Impedance of whole body	0.8	4.2	8.9	-1.3	-0.1	1.9	1.0	-2.7	-2.4	-2.7	-0.3	3.0	-2.7	-0.3	-2.9
Bipolar Disorder or Schizophrenia	0.7	1.7	9.3	0.1	-0.4	2.3	-3.0	0.7	1.0	1.1	0.3	-1.1	0.2	1.0	-1.1
Irritable Bowel Disease (IBD)	0.7	1.7	4.6	-1.0	-0.2	-1.5	2.1	-1.8	-1.6	-1.7	-0.6	1.3	-1.3	0.3	-0.4
Primary Biliary Cirrhosis	0.7	1.0	2.5	-0.0	-0.2	1.0	0.1	1.2	1.5	1.3	1.2	-0.5	-0.1	1.6	-1.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.9	-1.4	1.4	1.0	1.7	0.4	-0.1	-0.4	-0.1	0.8	-0.4	1.2	-0.2
Cardiovascular Disease	0.7	2.2	9.4	-1.2	1.0	-0.8	3.1	-1.9	-1.7	-1.4	-0.5	1.9	-1.3	0.3	0.0
Medication for hormone replacement therapy	0.7	0.8	4.9	0.4	-0.7	0.0	-0.3	-0.9	-0.8	-0.7	-0.6	0.0	-0.7	-2.2	1.0
Townsend deprivation index at recruitment	0.7	0.9	6.9	0.5	0.9	-0.2	0.3	0.1	0.5	0.7	0.1	-0.3	1.4	2.6	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	9.1	1.5	-0.5	3.0	-1.6	-1.0	-0.4	-0.5	-0.4	-0.8	-1.5	-0.4	-1.3
Chronic bronchitis/emphysema (father)	0.7	0.9	4.5	-0.1	0.2	1.4	-1.4	0.6	0.7	0.4	-0.0	-0.3	-0.7	2.1	-0.6
Trunk fat mass	0.7	2.9	20.5	-1.5	-0.8	-0.9	-4.5	-1.3	-1.3	-0.9	-1.2	1.2	-1.1	-0.1	-1.4
Waist circumference	0.7	2.5	18.7	-1.7	-0.6	-1.2	-4.3	-0.9	-0.7	-0.5	-1.2	1.3	-0.5	0.4	-1.0
Hair/balding pattern: Pattern 2	0.7	0.9	2.5	-0.1	-1.6	0.4	0.2	-1.1	-0.9	-0.8	-0.9	0.6	-1.6	-1.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	6.4	1.2	-0.5	2.5	-1.6	-1.1	-0.4	-0.4	-0.6	-0.3	-1.6	-0.6	-1.7
Mouth/teeth dental problems	0.7	1.1	5.5	-2.3	1.3	-0.2	1.2	-0.8	-0.9	-0.7	-1.0	1.3	-0.3	0.0	-0.6
Fluid intelligence score	0.7	1.4	4.6	1.7	-1.6	0.5	-0.4	1.1	1.5	1.1	0.9	-2.2	0.5	-0.1	0.8
Illnesses of siblings	0.7	1.0	2.7	0.3	0.1	-0.5	0.1	-1.1	-1.1	-1.5	-0.3	1.5	-1.7	-1.4	0.5
Father’s age at death	0.7	1.0	3.3	0.9	-1.8	-0.5	-1.6	0.8	0.6	0.4	-0.3	-1.6	0.7	0.5	0.3
Breastfed as a baby	0.7	0.9	5.3	-0.5	-0.5	0.8	-0.5	-1.1	-0.7	-0.7	-0.4	0.2	-1.4	-0.3	-2.3
Birth weight	0.7	1.5	2.8	-1.0	-0.7	0.5	-0.9	-1.6	-1.4	-1.5	-1.3	1.1	-1.7	0.3	-1.6
Age at last live birth	0.7	1.0	2.6	-1.6	-1.1	0.0	0.8	-1.2	-0.9	-1.3	-0.6	0.6	-1.4	-1.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	5.8	0.2	2.0	1.0	1.2	-0.8	-1.0	-0.9	-0.4	1.6	-0.9	0.3	-2.4
Qualifications: nursing, teaching	0.7	1.0	3.2	0.6	-1.5	-0.4	-1.2	-0.5	-0.7	-0.8	-0.3	-0.0	-1.1	-1.8	-1.6
Mineral and other dietary supplements	0.7	0.9	3.4	-0.1	-0.7	-0.1	-1.3	0.9	1.0	1.0	1.2	-0.7	0.7	-0.4	1.9
Medication: Gliclazide	0.7	0.8	1.5	-0.9	1.2	-1.2	1.2	1.1	0.7	0.9	0.5	0.3	1.1	0.2	0.2
Risk taking	0.7	1.1	2.5	0.9	-1.4	-0.4	-1.6	-0.6	-1.1	-0.7	-1.2	-0.4	-1.1	-1.4	-0.7
Supplements: Calcium	0.7	0.7	2.4	-0.0	-0.6	-1.3	0.5	-0.3	-1.1	-1.3	-1.5	0.0	-0.4	-0.7	0.4
Intelligence (Savage-Jansen 2018)	0.6	1.8	5.9	1.6	-1.6	0.9	0.7	1.7	2.1	1.3	0.6	-2.4	0.3	-0.2	0.1
Alzheimer’s Disease (in father)	0.6	0.7	2.4	1.5	-0.3	1.0	-1.4	-0.0	-0.0	0.1	0.7	-0.7	-0.8	-0.7	-0.9
Ovarian Cancer	0.6	0.8	6.1	0.4	-0.0	-0.7	0.3	-0.3	0.0	-0.1	1.3	-0.5	0.7	2.5	0.5
Body Mass Index (BMI) (2010)	0.6	0.8	2.4	-1.2	0.2	-0.5	-1.4	0.2	0.4	0.4	0.2	0.8	-0.1	-1.5	1.6
Schizophrenia (2014)	0.6	1.4	6.1	-0.3	-1.9	1.5	-2.5	0.5	0.6	1.0	-1.0	-1.4	0.6	-0.4	-0.3
Blood Platelet Count	0.6	7.3	42.4	-0.4	0.3	1.0	6.5	-2.7	-2.5	-2.6	-0.0	1.5	-3.9	-0.9	-2.2
Blood White Count	0.6	4.6	13.2	-2.5	1.7	0.2	3.5	-2.2	-1.6	-1.7	-0.1	3.6	-2.2	0.5	-2.4
BMI	0.6	3.5	21.7	0.8	0.1	-1.7	-4.7	1.5	1.5	1.6	0.6	-0.4	2.0	1.7	1.5
Systolic Blood Pressure	0.6	2.9	13.2	-0.8	0.3	1.4	3.6	-2.0	-2.0	-2.0	-0.9	0.2	-1.4	1.2	-1.6
Number of treatments/medications taken	0.6	1.1	3.5	-0.9	1.8	-1.9	-0.6	-0.0	-0.5	-0.3	0.0	1.6	0.9	0.9	0.6
Hearing difficulty/problems: Yes	0.6	0.9	2.9	-0.2	0.7	0.9	-0.3	-0.8	-0.5	-0.8	0.0	1.7	-1.5	0.9	-1.4
Systolic blood pressure, automated reading	0.6	1.7	5.3	-0.1	0.2	1.5	1.3	-1.8	-1.4	-1.2	-1.1	0.0	-1.4	1.2	-2.3
Diabetes (mother)	0.6	0.8	3.3	-0.4	-0.2	-0.7	0.2	-0.7	-0.8	-1.0	-0.5	1.8	-1.5	-0.0	-1.0
Trunk fat percentage	0.6	2.3	19.2	-1.0	-0.7	-0.6	-4.4	-1.1	-1.0	-0.7	-0.7	1.0	-0.9	0.5	-1.2
Average weekly fortified wine intake	0.6	0.8	3.3	-1.7	0.3	-0.8	-0.8	0.4	0.4	0.3	0.2	0.2	0.7	0.6	1.8
Body mass index (BMI)	0.6	2.5	14.9	0.8	-0.2	-1.1	-3.9	1.3	1.3	1.6	0.3	-1.5	1.6	1.1	1.0
Arm fat percentage (right)	0.6	2.3	23.5	0.0	-0.1	-0.8	-4.8	0.3	0.5	0.9	0.3	-0.2	0.6	1.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.7	0.5	1.3	-1.0	-0.5	0.9	0.9	1.1	1.2	0.2	1.0	0.3	-0.0
Lung cancer (father)	0.6	0.7	3.3	-0.7	1.8	0.8	0.1	-0.1	-0.4	-0.1	-0.4	1.7	0.3	0.7	-0.6
Illnesses of mother	0.6	0.8	3.3	-1.1	1.8	0.3	-0.5	0.2	0.5	0.3	1.3	1.4	0.2	-0.3	0.2
Impedance of arm (left)	0.6	3.0	7.5	-1.7	-0.0	1.3	-0.1	-2.1	-1.8	-2.1	-0.1	2.5	-2.2	-0.4	-2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.2	0.1	-0.3	-1.0	-1.2	1.1	0.7	0.7	0.4	-0.6	1.4	0.7	1.5
Medication: Blood pressure	0.6	1.1	3.3	-1.1	1.6	-1.1	1.8	-0.9	-0.9	-0.7	-0.0	1.7	-0.1	0.5	-0.2
Medication: Ibuprofen	0.6	0.7	2.3	0.7	0.9	-0.9	-1.5	0.7	0.8	0.8	1.2	0.1	0.7	0.6	-0.1
Mean time to correctly identify matches	0.6	1.1	2.6	-1.0	-0.2	-0.3	-0.1	0.9	1.1	0.7	-1.5	-0.9	1.6	1.4	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.8	-1.1	0.4	-0.5	0.6	1.0	0.6	0.9	0.1	-0.5	1.3	1.3	0.9
Illnesses of siblings: Diabetes	0.6	0.8	3.2	-1.6	-0.9	0.2	-0.5	-0.6	-0.7	-0.3	-1.2	-0.3	-0.4	0.4	-1.8
Arm fat percentage (left)	0.6	2.2	23.1	0.3	-0.1	-0.6	-4.8	0.5	0.7	1.0	0.4	-0.3	0.6	0.9	-0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	4.2	0.8	0.9	0.3	0.3	0.1	0.4	0.2	2.0	0.4	0.3	0.6	-1.3
Medication: Aspirin	0.6	0.7	5.2	-0.1	0.2	-0.4	-0.1	0.8	0.3	0.5	0.2	0.1	0.8	-1.3	2.3
Eye problems/disorders: Glaucoma	0.6	0.7	3.8	-0.7	0.8	0.2	1.9	-0.0	-0.0	0.5	0.2	0.1	0.9	-1.3	0.5
Commuting to job workplace: Cycle	0.6	0.8	3.8	-1.6	2.0	0.5	-0.2	0.2	-0.1	0.2	0.2	0.1	1.2	0.8	-0.4
Prostate Cancer	0.5	0.7	3.7	1.9	0.0	0.1	0.0	0.3	0.4	0.6	1.6	-1.1	0.3	0.6	0.1
Crohns Disease (2012)	0.5	0.9	4.3	-0.1	-0.4	-2.1	0.5	0.8	0.6	0.2	0.0	-0.5	0.6	0.6	1.9
Triglycerides	0.5	0.9	3.7	-1.4	1.1	-0.1	1.9	-0.3	-0.3	-0.4	0.4	1.4	-0.4	0.8	-0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.3	-0.5	-0.5	-1.5	-1.2	0.4	-0.3	-0.2	-1.4	0.3	0.8	-0.4	0.2
Hand grip strength (right)	0.5	1.4	5.6	-0.3	-2.0	-0.4	0.5	-0.6	-0.8	-0.5	-1.9	-0.9	-0.8	-2.4	1.0
Age when periods started (menarche)	0.5	1.1	2.5	1.1	-0.6	0.7	0.4	1.4	0.9	0.8	0.6	-1.6	1.5	1.5	0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.9	0.2	0.1	-1.1	-1.4	0.9	0.8	0.9	0.4	-0.4	0.5	0.2	0.4
Financial difficulties in last 2 years	0.5	0.7	1.5	-0.4	-1.0	-0.9	-0.3	-0.6	-1.2	-1.2	-0.8	0.3	-1.1	0.6	0.8
Hip circumference	0.5	2.2	20.1	0.7	0.3	-0.6	-4.5	0.7	0.7	1.1	0.6	-0.8	0.8	0.7	-1.0
Body fat percentage	0.5	2.0	21.0	-0.3	-0.5	-0.4	-4.6	-0.6	-0.5	-0.2	-0.4	0.6	-0.4	0.7	-1.1
Leg fat percentage (right)	0.5	1.8	18.7	0.0	-0.4	-0.4	-4.3	-0.6	-0.4	-0.2	-0.6	0.8	-0.5	0.6	-1.0
Whole body fat mass	0.5	2.1	18.0	-1.0	-0.5	-0.7	-4.2	-0.9	-0.9	-0.6	-0.9	0.8	-0.8	0.2	-1.3
Leg fat mass (right)	0.5	1.9	19.6	-0.6	-0.3	-0.8	-4.4	-0.4	-0.3	0.0	-0.5	0.8	-0.3	0.5	-1.0
Mood swings	0.5	0.9	5.4	0.2	0.9	-0.7	-0.4	0.1	-0.3	-0.2	0.0	1.4	0.8	2.3	0.9
Loneliness, isolation	0.5	0.7	3.7	-0.0	-0.4	1.9	1.5	-0.3	-0.1	-0.0	0.8	-0.3	-0.4	0.9	-1.0
Eye problems/disorders: Cataract	0.5	0.6	2.0	-1.3	0.3	-0.2	-0.1	-0.3	-0.4	-0.3	-0.5	1.4	-0.6	-1.3	-0.6
Medication for cholesterol	0.5	0.8	2.0	-0.1	-0.3	-0.6	-1.3	1.4	1.3	1.0	1.1	-0.3	1.2	-0.2	0.3
Number of self-reported non-cancer illnesses	0.5	0.8	3.5	-1.3	0.6	-1.9	-0.0	0.7	0.0	0.5	-0.5	0.4	1.4	0.8	0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	4.2	0.6	0.0	0.4	0.0	-0.4	0.1	-0.7	0.4	0.9	-2.0	-0.4	-0.6
Medication: Blood pressure	0.5	0.9	5.7	-0.0	0.8	1.3	0.9	-0.5	-0.1	0.0	-0.2	0.0	-0.8	1.2	-2.4
Medication: Paracetamol	0.5	0.8	2.6	1.1	1.1	0.4	-0.5	-0.7	-0.3	-0.5	1.1	0.9	-0.2	1.6	-0.9
Illnesses of father: High blood pressure	0.5	0.6	2.1	0.9	-0.6	1.4	-0.3	0.0	-0.2	-0.1	-1.3	-1.3	-0.7	-0.5	0.4
Alcohol drinker status: Never	0.5	0.6	2.1	-1.3	-0.7	-1.3	-0.0	0.4	-0.2	-0.3	-1.4	0.8	0.0	0.1	0.7
Leg fat percentage (left)	0.5	2.0	22.0	0.5	-0.8	0.0	-4.7	-0.0	0.1	0.3	-0.3	-0.0	-0.0	0.7	-0.5
Ever depressed for a whole week	0.5	0.6	2.0	-1.0	0.2	-0.8	-0.4	0.8	0.2	0.3	0.2	0.7	1.4	-0.6	1.2
Pain experienced in last month	0.5	0.8	2.3	1.2	0.3	1.4	-0.1	-0.6	0.1	-0.4	1.5	-0.3	-1.5	-0.9	-0.3
Leg fat mass (left)	0.5	1.9	20.6	-0.3	-0.6	-0.6	-4.5	-0.1	-0.1	0.3	-0.4	0.1	0.0	0.6	-0.7
Schizophrenia (2018)	0.4	0.8	4.8	0.0	-1.0	0.9	-2.2	0.6	0.5	0.9	-0.7	-0.9	0.6	-0.2	0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	2.3	-0.4	-1.1	-1.5	1.0	-0.1	-0.0	-0.0	-0.8	-0.1	0.7	-0.5	0.1
Crohns Disease (2017)	0.4	1.0	4.4	-1.1	-1.2	-2.1	1.0	-0.3	-0.4	-0.6	-0.4	-0.2	-0.3	-0.7	1.4
Major Depression (MDD)	0.4	0.5	2.7	0.2	1.4	1.7	-0.6	0.4	0.3	0.4	-0.3	0.4	-0.4	0.3	0.1
Age at First Birth	0.4	0.6	2.2	0.4	-0.4	0.6	1.2	0.2	0.0	0.2	-0.2	-1.5	-0.1	-1.4	0.8
Blood Eosinophil Count	0.4	3.2	10.2	-2.0	1.4	-0.8	3.2	-2.2	-2.1	-1.9	-0.8	2.0	-1.5	-0.5	-1.4
Average weekly spirits intake	0.4	0.5	2.1	-0.8	-0.2	-1.1	1.0	-0.0	-0.1	-0.2	-0.7	0.5	0.4	0.3	1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.8	-0.4	-0.9	-0.8	-0.3	0.5	-0.3	0.0	-1.3	-0.4	0.7	-0.2	0.7
Medication: Metformin	0.4	0.5	2.4	-0.1	-0.5	-1.4	-0.2	0.6	0.3	0.5	-0.2	-0.3	0.7	-0.6	1.5
Current tobacco smoking	0.4	0.7	5.6	0.6	-0.6	-0.7	-2.4	-0.3	-0.3	0.1	-0.7	-0.2	-0.0	-0.4	0.7
Had other major operations	0.4	0.4	0.8	-0.4	0.8	0.9	-0.7	0.5	0.8	0.7	0.5	-0.9	0.6	0.4	-0.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.6	0.0	0.4	-1.2	0.0	-0.2	-0.9	-0.7	-0.7	0.4	1.1	-0.1	1.3
Mouth/teeth dental problems: Dentures	0.4	0.6	1.9	1.3	-0.9	1.4	-1.2	-0.1	0.4	0.0	0.7	0.2	-0.4	0.6	-0.6
Arm fat mass (right)	0.4	1.5	15.6	-0.5	-0.2	-0.9	-4.0	-0.0	-0.0	0.4	-0.4	-0.1	0.1	0.8	-0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	-1.2	-0.5	-1.3	-1.1	-0.1	-0.3	-0.0	-0.2	0.8	0.3	-0.5	0.3
Medication: Allopurinol	0.4	0.6	2.5	-1.6	0.8	1.3	-0.0	-0.1	0.1	0.0	0.1	0.1	-0.7	-0.4	-1.1
Heart disease (mother)	0.4	0.5	2.2	-1.5	-0.4	-0.5	0.5	-0.2	-0.7	-0.5	-1.2	0.1	-0.0	-0.1	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.6	0.5	-0.4	-0.5	-0.1	-0.1	0.0	-0.3	-1.3	1.2	-1.0	-0.1	-1.1
Medication: Aspirin	0.4	0.6	3.8	-0.3	-0.1	-0.8	-0.2	0.5	-0.1	0.2	-0.0	0.3	0.8	-1.2	1.9
Average weekly red wine intake	0.4	0.6	1.8	-1.3	-0.6	-1.2	0.9	0.5	0.4	0.2	0.1	-0.7	0.2	-0.9	0.8
Back pain experienced in last month	0.4	0.5	2.2	-0.7	-1.1	-0.4	-1.2	-0.0	-0.6	-0.5	-1.5	-0.0	0.1	-0.7	-0.0
Osteoporosis (self-reported)	0.4	0.5	2.0	0.8	1.4	0.7	0.9	0.8	0.7	0.2	0.4	0.1	-0.6	0.5	-0.8
Osteoarthritis (self-reported)	0.4	0.6	1.8	-1.0	1.4	0.3	-0.5	-0.1	0.3	0.6	0.2	1.0	0.9	0.8	-0.7
Arm fat mass (left)	0.4	1.7	17.8	-0.2	-0.2	-0.6	-4.2	0.1	0.3	0.6	-0.1	-0.3	0.2	0.9	-0.8
Ever taken oral contraceptive pill	0.4	0.4	1.9	0.6	-0.3	-1.1	0.2	0.9	0.5	0.4	0.4	-0.3	0.5	-0.1	1.4
Commuting to job workplace: Public transport	0.4	0.4	2.3	0.6	-0.2	0.5	-0.6	-0.3	0.3	0.1	1.5	-0.2	0.1	1.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.5	1.3	-0.2	0.1	1.6	0.1	-0.1	0.0	-1.0	-1.0	0.1	0.5	-0.7
Medication: Atorvastatin	0.4	0.5	2.8	-0.4	0.4	0.3	1.7	1.1	0.7	0.8	-0.2	-0.4	0.3	-0.3	0.8
Ever smoked	0.4	0.8	2.5	1.6	-0.4	0.6	-1.3	0.7	0.6	0.5	0.9	-1.6	0.1	0.0	0.4
Age started oral contraceptive pill	0.4	0.5	1.9	0.9	0.9	-0.7	0.3	0.7	0.4	0.3	0.1	-0.3	1.4	1.0	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.0	-0.2	0.6	-0.5	1.4	-0.3	-0.5	-0.7	0.4	1.3	-0.3	-0.0	0.9
Depression (Nagel 2018)	0.3	0.5	4.8	-0.8	-0.3	0.6	-2.2	0.1	0.0	0.2	0.3	0.3	0.1	-0.0	-0.4
Fasting Glucose	0.3	0.3	1.5	0.3	-1.2	-1.1	0.3	-0.3	-0.4	-0.2	-0.5	-0.2	0.3	-0.3	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	3.2	-0.5	-0.3	-1.8	-1.2	0.0	-0.5	-0.1	-0.2	0.8	0.9	-0.7	0.0
Hair Pigment	0.3	8.2	18.1	-4.3	0.3	-0.2	3.5	-2.9	-3.3	-3.1	-3.2	4.1	-2.9	-1.3	-1.1
Tanning	0.3	3.8	17.1	3.6	-1.1	-0.9	-0.9	1.6	1.5	1.1	1.5	-4.1	1.9	0.8	0.8
Angina	0.3	0.4	1.3	0.5	1.1	0.5	-0.8	0.9	0.5	0.5	0.6	-0.1	0.7	0.1	0.3
Supplements: Zinc	0.3	0.3	1.3	-0.4	-0.3	0.0	-1.1	-0.2	-0.4	-0.5	-0.8	0.4	-0.1	0.4	-0.9
Leg fat-free mass (left)	0.3	1.5	9.6	-1.9	-0.3	-1.4	-3.1	-0.3	-0.5	-0.0	-1.2	0.3	-0.1	-0.4	-0.9
Relative age voice broke	0.3	0.5	1.2	1.1	1.0	-0.3	0.5	0.5	0.6	0.7	1.0	0.1	1.1	0.3	0.2
Leg predicted mass (left)	0.3	1.5	9.9	-1.8	-0.1	-1.3	-3.1	-0.3	-0.5	0.0	-1.2	0.3	-0.1	-0.3	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.4	-0.3	-0.7	-0.4	0.3	-0.3	-1.2	-0.5	-1.2	-0.2	0.5	0.8	0.1
Had menopause	0.3	0.4	1.0	0.8	-0.7	-0.1	-0.8	-0.3	0.3	0.4	-0.1	-0.9	0.2	0.7	-1.0
Qualifications: None of the above	0.3	0.6	3.0	-0.2	-0.1	1.2	-0.3	-0.3	-0.2	-0.6	-0.7	0.5	-0.8	1.7	-0.5
Heart attack	0.3	0.4	1.4	-0.4	0.3	-0.7	0.9	-0.3	-0.5	-0.7	0.3	1.2	-0.3	0.0	0.7
Weight	0.3	1.7	14.6	-1.1	-0.5	-1.0	-3.8	-0.6	-0.8	-0.3	-1.0	0.3	-0.4	-0.2	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.7	0.5	-1.1	0.1	0.5	0.3	0.4	0.2	0.7	-0.8	-0.0	-1.7	1.0
Exposure to tobacco smoke at home	0.3	0.4	2.5	0.7	0.4	1.6	0.5	0.5	0.3	0.7	-0.3	0.1	0.4	0.0	0.1
Headache pain in last month	0.3	0.6	2.9	-0.1	0.4	0.3	1.7	0.4	0.3	0.4	0.6	-0.5	0.5	1.5	-0.1
Medication: Amlodipine	0.3	0.5	1.4	0.1	1.2	0.3	0.7	0.6	0.5	0.5	0.9	-0.7	0.3	1.1	-0.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.9	1.4	-0.1	-0.7	0.4	0.1	-0.2	-0.0	-0.4	-0.6	0.0	-0.7	0.7
High blood pressure (siblings)	0.3	0.4	1.6	0.6	-0.7	1.3	-0.4	-0.5	-0.1	-0.3	0.5	-0.7	-0.6	0.4	-0.2
Qualifications: College or University degree	0.3	1.0	2.8	1.6	0.8	1.7	-0.5	-0.0	0.6	0.4	1.3	-0.5	-0.5	-1.0	-1.3
Emphysema/chronic bronchitis	0.3	0.4	1.3	-0.7	-0.5	-0.5	-1.0	0.3	0.3	0.4	-0.7	0.5	0.3	1.2	-0.3
Diabetes diagnosed by doctor	0.3	0.5	2.7	-0.6	-0.5	-1.6	-0.1	0.1	-0.5	-0.3	-0.9	0.1	0.4	-1.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	2.4	0.2	0.2	-1.6	-0.5	0.2	-0.2	-0.3	1.3	0.4	0.4	-0.4	0.5
Smoking status: Current	0.3	0.5	4.6	0.8	-0.2	-0.6	-2.2	-0.1	-0.1	0.3	-0.3	-0.4	0.2	0.2	0.6
Mother’s age at death	0.3	0.4	1.6	1.2	0.3	0.2	-0.3	0.1	0.3	0.2	0.8	-0.2	0.9	0.4	-1.1
Fractured/broken bones in last 5 years	0.3	0.4	2.9	-1.7	-0.3	-0.6	-0.6	-0.2	-0.2	-0.2	-0.5	0.4	0.7	0.3	-0.2
Diastolic blood pressure, automated reading	0.3	1.0	5.3	0.3	0.9	2.3	0.3	-0.3	0.8	1.1	0.4	0.0	-0.0	1.1	-1.8
Relative age of first facial hair	0.2	0.4	1.0	0.6	-0.1	-1.0	0.9	-0.6	-0.7	-0.6	-0.7	0.8	-0.1	-0.9	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.6	-0.2	-0.9	-0.0	-1.1	-0.0	-0.2	-0.0	-0.2	0.1	-0.1	-0.4	1.2
Trunk fat-free mass	0.2	1.1	2.7	-1.3	-0.0	-0.5	-1.0	-1.0	-1.2	-0.8	-1.6	0.5	-1.1	-0.9	-1.6
Trunk predicted mass	0.2	1.0	2.6	-1.3	0.1	-0.4	-0.9	-0.9	-1.1	-0.7	-1.5	0.5	-1.1	-0.9	-1.6
Age at first live birth	0.2	0.4	1.2	-0.3	0.1	-0.2	0.9	-0.6	-0.3	-0.6	-0.0	0.7	-0.9	-0.1	-1.1
Angina (self-reported)	0.2	0.2	0.9	0.2	1.0	0.4	-0.7	0.5	0.1	0.2	0.4	-0.1	0.5	-0.3	0.5
Whole body fat-free mass	0.2	1.0	3.7	-1.4	-0.1	-0.7	-1.9	-0.6	-0.8	-0.4	-1.3	0.3	-0.6	-0.7	-1.2
Leg fat-free mass (right)	0.2	1.3	10.0	-1.6	-0.4	-1.1	-3.2	0.1	-0.2	0.4	-1.0	-0.4	0.4	-0.5	-0.3
Whole body water mass	0.2	1.0	3.5	-1.5	-0.1	-0.9	-1.9	-0.7	-0.9	-0.5	-1.4	0.3	-0.6	-0.7	-1.2
Leg predicted mass (right)	0.2	1.3	10.0	-1.6	-0.4	-1.1	-3.2	0.1	-0.2	0.3	-0.9	-0.4	0.4	-0.6	-0.2
Hearing aid user	0.2	0.2	1.2	0.0	-0.3	-1.1	-0.4	0.0	-0.0	-0.1	0.0	0.1	0.1	1.0	0.6
Basal metabolic rate	0.2	1.2	6.1	-1.5	-0.2	-0.8	-2.5	-0.7	-0.9	-0.4	-1.3	0.3	-0.6	-0.6	-1.2
Arm fat-free mass (left)	0.2	0.8	2.7	-1.3	-0.1	-0.6	-1.6	-0.7	-0.9	-0.5	-1.4	0.2	-0.7	-0.3	-1.1
Arm predicted mass (left)	0.2	0.8	2.4	-1.3	0.2	-0.6	-1.6	-0.7	-0.9	-0.4	-1.4	0.3	-0.5	-0.2	-1.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	0.0	-0.1	0.5	-0.8	0.7	0.3	0.3	0.1	-0.4	-0.2	0.5	-0.0
Sitting height	0.1	0.8	2.3	0.1	-0.1	0.4	0.3	-1.0	-1.4	-1.4	-0.1	-0.3	-1.5	-0.6	-1.5
Arm fat-free mass (right)	0.1	0.7	3.0	-1.2	-0.2	-0.6	-1.7	-0.5	-0.7	-0.3	-1.4	0.3	-0.6	-0.5	-0.6
Arm predicted mass (right)	0.1	0.6	3.2	-1.1	-0.1	-0.6	-1.8	-0.1	-0.3	0.0	-1.1	0.1	-0.3	-0.4	-0.5
Wears glasses or contact lenses	0.1	0.2	0.7	-0.6	-0.0	-0.8	0.2	-0.0	-0.1	0.0	-0.4	0.6	0.3	0.1	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

LLGL2

Models

Trait associations