Best TWAS P=1.82e-09 · Best GWAS P=2.92e-09 conditioned to 0.00357
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RPS6KL1 | 0.04 | 0.02 | lasso | 5 | 0.02 | 4.8e-04 | 4.0 | -5.1 | 2.9e-07 | 0.80 | 0.02 | 0.94 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | YLPM1 | 0.10 | 0.03 | lasso | 6 | 0.02 | 7.9e-03 | -5.9 | 5.8 | 8.8e-09 | -0.93 | 0.00 | 0.96 | FALSE |
| 3 | GTEx | Muscle Skeletal | DLST | 0.28 | 0.26 | enet | 23 | 0.26 | 2.1e-25 | -5.3 | -5.2 | 2.5e-07 | 0.81 | 0.07 | 0.92 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | RPS6KL1 | 0.08 | 0.08 | enet | 11 | 0.07 | 1.5e-04 | 5.3 | 5.7 | 9.2e-09 | -0.66 | 0.05 | 0.94 | FALSE |
| 5 | GTEx | Testis | AREL1 | 0.20 | 0.14 | enet | 34 | 0.13 | 2.1e-06 | 5.3 | 6.0 | 1.8e-09 | -0.60 | 0.05 | 0.95 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPS6KL1 | 0.03 | 0.02 | lasso | 3 | 0.02 | 8.5e-06 | 5.3 | 5.2 | 1.7e-07 | -0.68 | 0.05 | 0.95 | FALSE |