Best TWAS P=2.67e-08 · Best GWAS P=6.93e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PCCB | 0.09 | 0.19 | lasso | 7 | 0.18 | 1.2e-21 | -5.2 | -5.1 | 2.9e-07 | 0.98 | 0.02 | 0.98 | FALSE |
2 | GTEx | Esophagus Mucosa | PCCB | 0.10 | 0.12 | lasso | 3 | 0.11 | 4.8e-08 | -5.4 | -5.6 | 2.7e-08 | 0.98 | 0.02 | 0.98 | TRUE |
3 | YFS | Blood | PCCB | 0.13 | 0.20 | lasso | 9 | 0.20 | 1.3e-64 | -5.4 | -5.1 | 2.9e-07 | 0.99 | 0.01 | 0.99 | FALSE |
4 | The Cancer Genome Atlas | Colon Adenocarcinoma | PCCB | 0.11 | 0.03 | blup | 54 | 0.04 | 2.3e-03 | -5.4 | -5.4 | 5.3e-08 | 0.98 | 0.01 | 0.76 | FALSE |
5 | The Cancer Genome Atlas | Esophageal Carcinoma | PCCB | 0.15 | 0.03 | blup | 54 | 0.05 | 9.6e-03 | -5.2 | -5.5 | 3.1e-08 | 0.94 | 0.01 | 0.70 | FALSE |
6 | The Cancer Genome Atlas | Glioblastoma Multiforme | PCCB | 0.10 | 0.03 | blup | 53 | 0.02 | 5.8e-02 | -5.2 | -5.5 | 4.0e-08 | 0.97 | 0.01 | 0.75 | FALSE |
7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PCCB | 0.12 | 0.05 | enet | 7 | 0.09 | 9.7e-11 | -5.1 | -5.6 | 2.7e-08 | 0.88 | 0.01 | 0.99 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STAG1 | 0.04 | 0.02 | lasso | 3 | 0.02 | 4.1e-03 | 4.6 | -5.3 | 1.4e-07 | 0.81 | 0.03 | 0.91 | FALSE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | PCCB | 0.11 | 0.10 | lasso | 3 | 0.10 | 1.3e-11 | -5.4 | -5.4 | 7.4e-08 | 1.00 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | STAG1 | 0.02 | 0.02 | enet | 6 | 0.02 | 3.5e-03 | -5.2 | -5.2 | 1.6e-07 | 0.97 | 0.02 | 0.89 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PCCB | 0.13 | 0.10 | lasso | 4 | 0.10 | 2.4e-11 | -5.2 | -5.3 | 1.4e-07 | 0.96 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | STAG1 | 0.05 | 0.00 | blup | 151 | 0.01 | 2.9e-02 | -5.2 | -5.3 | 1.2e-07 | 0.94 | 0.03 | 0.96 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PCCB | 0.06 | 0.02 | lasso | 2 | 0.03 | 2.3e-04 | 4.2 | -5.3 | 1.5e-07 | 0.86 | 0.02 | 0.96 | FALSE |
14 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PCCB | 0.14 | 0.10 | enet | 6 | 0.10 | 1.0e-06 | -5.4 | -5.2 | 2.0e-07 | 0.99 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PCCB | 0.07 | 0.04 | lasso | 1 | 0.02 | 1.1e-02 | -5.4 | -5.4 | 7.1e-08 | 0.99 | 0.01 | 0.96 | FALSE |