Hub : Traits :

Frequency of tenseness / restlessness in last 2 weeks

404 significantly associated models · 35 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	43682052	45148674	1	1	1.4e-07	9.8e-07	0.130	90	TCAIM
2	3	48381826	50546340	8	1	1.0e-07	7.0e-07	0.028	80	GPX1
3	3	135273949	136755553	2	1	2.7e-08	6.9e-08	1.000	100	PCCB
4	12	109295508	110704487	2	1	3.4e-08	4.8e-08	0.158	93	KCTD10
5	13	31078511	32595740	1	1	4.6e-09	2.1e-06	0.177	92	B3GALTL
6	17	42607368	45796313	21	1	3.0e-14	6.8e-12	1.000	100	CRHR1-IT1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Neuroticism (Nagel 2018)	20.60	6	3	6.7	0.97	0.0011	B3GALTL CRHR1-IT1 GPX1 KCTD10 PCCB TCAIM
Neuroticism	18.74	5	4	8.9	0.98	0.0033	B3GALTL CRHR1-IT1 GPX1 KCTD10 PCCB
Depressed Affect (Nagel 2018)	17.44	4	3	6.7	1.00	0.0013	CRHR1-IT1 GPX1 KCTD10 PCCB
Neuroticism score	17.25	5	4	8.9	0.99	0.0012	B3GALTL CRHR1-IT1 GPX1 KCTD10 PCCB
Hair/balding pattern: Pattern 4	16.90	1	1	2.2	0.00	1.0000	CRHR1-IT1
Miserableness	15.60	5	2	4.4	0.98	0.0035	B3GALTL CRHR1-IT1 GPX1 KCTD10 PCCB
Fed-up feelings	14.51	3	3	6.7	0.00	1.0000	CRHR1-IT1 GPX1 PCCB
Mood swings	14.40	4	2	4.4	1.00	0.0025	CRHR1-IT1 GPX1 KCTD10 TCAIM
Sensitivity / hurt feelings	13.81	3	2	4.4	0.00	1.0000	CRHR1-IT1 KCTD10 PCCB
Worry (Nagel 2018)	13.07	4	3	6.7	0.98	0.0197	B3GALTL CRHR1-IT1 KCTD10 PCCB
Frequency of tiredness / lethargy in last 2 weeks	12.40	4	1	2.2	0.98	0.0247	GPX1 KCTD10 PCCB TCAIM
Qualifications: College or University degree	11.82	3	3	6.7	0.00	1.0000	B3GALTL CRHR1-IT1 GPX1
Nervous feelings	10.56	3	2	4.4	0.00	1.0000	CRHR1-IT1 KCTD10 PCCB
Neuroticism (2016)	10.43	1	1	2.2	0.00	1.0000	CRHR1-IT1
Worrier / anxious feelings	10.20	3	2	4.4	0.00	1.0000	CRHR1-IT1 KCTD10 PCCB
Headache pain in last month	10.04	1	1	2.2	0.00	1.0000	CRHR1-IT1
Worry too long after embarrassment	10.00	3	1	2.2	0.00	1.0000	CRHR1-IT1 KCTD10 PCCB
Medication: Paracetamol	9.98	3	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1 KCTD10
Depression (Nagel 2018)	9.96	2	1	2.2	0.00	1.0000	CRHR1-IT1 PCCB
Medication: Paracetamol	9.77	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Relative age of first facial hair	9.55	1	1	2.2	0.00	1.0000	CRHR1-IT1
Intelligence (Savage-Jansen 2018)	9.35	3	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1 PCCB
Frequency of depressed mood in last 2 weeks	9.35	2	0	0.0	0.00	1.0000	CRHR1-IT1 PCCB
Hair/balding pattern: Pattern 3	8.95	1	1	2.2	0.00	1.0000	CRHR1-IT1
Qualifications: A levels/AS levels or equivalent	8.72	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Guilty feelings	8.53	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Frequency of unenthusiasm / disinterest in last 2 weeks	8.42	2	0	0.0	0.00	1.0000	GPX1 PCCB
Age at First Birth	8.17	1	1	2.2	0.00	1.0000	GPX1
Blood Red Count	7.88	1	1	2.2	0.00	1.0000	CRHR1-IT1
Pain experienced in last month	7.87	3	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1 KCTD10
Lung FVC	7.50	2	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1
Major Depression (MDD)	7.42	1	0	0.0	0.00	1.0000	GPX1
Age at first live birth	7.41	1	1	2.2	0.00	1.0000	GPX1
Loneliness, isolation	7.21	2	0	0.0	0.00	1.0000	CRHR1-IT1 GPX1
Irritable Bowel Disease (IBD)	7.17	1	1	2.2	0.00	1.0000	GPX1
Forced expiratory volume in 1-second (FEV1)	7.14	2	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1
Verbal and Numeric Reasoning (VNR)	7.09	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Impedance of arm (left)	6.94	3	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1 TCAIM
Relative age voice broke	6.83	1	1	2.2	0.00	1.0000	CRHR1-IT1
Tense / 'highly strung'	6.81	1	0	0.0	0.00	1.0000	PCCB
Irritability	6.71	2	1	2.2	0.00	1.0000	CRHR1-IT1 KCTD10
Fluid intelligence score	6.68	2	1	2.2	0.00	1.0000	GPX1 PCCB
Forced expiratory volume in 1-second (FEV1), Best measure	6.53	2	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1
Overall health rating	6.49	1	1	2.2	0.00	1.0000	GPX1
Age at last live birth	6.47	1	1	2.2	0.00	1.0000	GPX1
Seen doctor (GP) for nerves, anxiety, tension or depression	6.29	2	1	2.2	0.00	1.0000	B3GALTL TCAIM
Qualifications: None of the above	6.26	1	1	2.2	0.00	1.0000	GPX1
Ulcerative Colitis (UC)	6.24	1	1	2.2	0.00	1.0000	GPX1
Forced vital capacity (FVC)	6.03	2	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1
Forced vital capacity (FVC), Best measure	6.03	2	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.01	1	1	2.2	0.00	1.0000	CRHR1-IT1
Suffer from 'nerves'	5.88	1	0	0.0	0.00	1.0000	CRHR1-IT1
Ulcerative Colitis	5.84	1	1	2.2	0.00	1.0000	GPX1
Medication for pain relief, constipation, heartburn	5.81	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Ever unenthusiastic/disinterested for a whole week	5.78	1	0	0.0	0.00	1.0000	CRHR1-IT1
Impedance of arm (right)	5.66	2	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1
Ever highly irritable/argumentative for 2 days	5.64	1	0	0.0	0.00	1.0000	GPX1
Breast Cancer	5.51	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Ovarian Cancer	5.37	1	1	2.2	0.00	1.0000	CRHR1-IT1
Financial situation satisfaction	5.35	1	1	2.2	0.00	1.0000	GPX1
HDL Cholesterol	5.34	1	1	2.2	0.00	1.0000	KCTD10
Mouth/teeth dental problems: Mouth ulcers	5.34	1	1	2.2	0.00	1.0000	CRHR1-IT1
Crohns Disease (2017)	5.28	1	1	2.2	0.00	1.0000	GPX1
Qualifications: nursing, teaching	5.08	1	0	0.0	0.00	1.0000	GPX1
Leg pain on walking	5.07	1	0	0.0	0.00	1.0000	GPX1
Systolic blood pressure, automated reading	5.02	2	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1
Waist Hip Ratio (WHR)	4.94	3	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1 PCCB
Schizophrenia vs Biploar Disorder	4.89	1	0	0.0	0.00	1.0000	CRHR1-IT1
Hearing difficulty/problems with background noise	4.86	2	0	0.0	0.00	1.0000	CRHR1-IT1 KCTD10
Stomach or abdominal pain in last month	4.84	1	0	0.0	0.00	1.0000	PCCB
Impedance of whole body	4.79	2	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1
Qualifications: CSEs or equivalent	4.74	1	0	0.0	0.00	1.0000	GPX1
Mouth/teeth dental problems	4.72	2	0	0.0	0.00	1.0000	CRHR1-IT1 KCTD10
Neck or shoulder pain in last month	4.70	1	0	0.0	0.00	1.0000	GPX1
Age when periods started (menarche)	4.67	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Number of treatments/medications taken	4.51	1	1	2.2	0.00	1.0000	GPX1
Medication: Ibuprofen	4.39	1	0	0.0	0.00	1.0000	CRHR1-IT1
Mouth/teeth dental problems: Dentures	4.28	1	0	0.0	0.00	1.0000	GPX1
Alcohol intake frequency.	4.27	1	1	2.2	0.00	1.0000	CRHR1-IT1
Average weekly champagne plus white wine intake	4.27	1	0	0.0	0.00	1.0000	CRHR1-IT1
Crohns Disease (2012)	4.26	1	1	2.2	0.00	1.0000	GPX1
Taking other prescription medications	4.26	1	1	2.2	0.00	1.0000	GPX1
Medication: Ibuprofen (e.g. Nurofen)	4.23	1	0	0.0	0.00	1.0000	CRHR1-IT1
Body mass index (BMI)	4.21	1	1	2.2	0.00	1.0000	GPX1
Depression (self-reported)	4.15	1	0	0.0	0.00	1.0000	B3GALTL
Leg fat percentage (right)	4.13	1	1	2.2	0.00	1.0000	GPX1
Schizophrenia (2014)	4.10	1	1	2.2	0.00	1.0000	PCCB
Number of full brothers	4.10	1	0	0.0	0.00	1.0000	GPX1
Leg fat percentage (left)	4.07	1	1	2.2	0.00	1.0000	GPX1
Hearing difficulty/problems: Yes	4.05	1	0	0.0	0.00	1.0000	KCTD10
Handedness (chirality/laterality): Left-handed	4.02	1	0	0.0	0.00	1.0000	CRHR1-IT1
Medication: Co-codamol	3.99	1	0	0.0	0.00	1.0000	GPX1
Pain all over the body in last month	3.99	1	0	0.0	0.00	1.0000	GPX1
Schizophrenia (2018)	3.98	1	1	2.2	0.00	1.0000	PCCB
Systolic Blood Pressure	3.96	2	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1
Prostate Cancer	3.92	1	0	0.0	0.00	1.0000	GPX1
Peak expiratory flow (PEF)	3.92	2	1	2.2	0.00	1.0000	CRHR1-IT1 KCTD10
Smoking Status	3.85	1	1	2.2	0.00	1.0000	GPX1
Blood Eosinophil Count	3.83	2	1	2.2	0.00	1.0000	CRHR1-IT1 KCTD10
Pack years adult smoking proportion	3.80	1	0	0.0	0.00	1.0000	GPX1
Leg fat mass (left)	3.75	1	1	2.2	0.00	1.0000	GPX1
Father's age at death	3.74	1	0	0.0	0.00	1.0000	GPX1
Diastolic blood pressure, automated reading	3.74	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Leg fat mass (right)	3.72	1	1	2.2	0.00	1.0000	GPX1
Hair/balding pattern: Pattern 2	3.63	1	0	0.0	0.00	1.0000	CRHR1-IT1
Wheeze or whistling in the chest in last year	3.52	1	0	0.0	0.00	1.0000	GPX1
BMI	3.47	1	1	2.2	0.00	1.0000	GPX1
Commuting to job workplace: Cycle	3.42	1	0	0.0	0.00	1.0000	TCAIM
Qualifications: O levels/GCSEs or equivalent	3.41	1	0	0.0	0.00	1.0000	GPX1
Medication: Blood pressure	3.41	1	0	0.0	0.00	1.0000	CRHR1-IT1
Exposure to tobacco smoke at home	3.36	1	0	0.0	0.00	1.0000	GPX1
Age started oral contraceptive pill	3.32	1	0	0.0	0.00	1.0000	GPX1
Health satisfaction	3.19	1	0	0.0	0.00	1.0000	GPX1
Risk taking	3.11	1	0	0.0	0.00	1.0000	PCCB
Time employed in main current job	3.04	1	0	0.0	0.00	1.0000	CRHR1-IT1
Primary Biliary Cirrhosis	3.02	1	0	0.0	0.00	1.0000	CRHR1-IT1
Pack years of smoking	2.90	1	0	0.0	0.00	1.0000	GPX1
Arm fat mass (right)	2.78	1	1	2.2	0.00	1.0000	GPX1
Whole body fat mass	2.71	1	1	2.2	0.00	1.0000	GPX1
Body fat percentage	2.65	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Arm fat mass (left)	2.62	1	1	2.2	0.00	1.0000	GPX1
Trunk fat percentage	2.56	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Impedance of leg (left)	2.55	2	2	4.4	0.00	1.0000	CRHR1-IT1 GPX1
Hand grip strength (left)	2.54	1	1	2.2	0.00	1.0000	CRHR1-IT1
Arm fat percentage (right)	2.54	1	1	2.2	0.00	1.0000	GPX1
Arm fat percentage (left)	2.48	1	1	2.2	0.00	1.0000	GPX1
Comparative height size at age 10	2.45	4	0	0.0	-1.00	0.0025	CRHR1-IT1 GPX1 KCTD10 PCCB
Impedance of leg (right)	2.37	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Arm fat-free mass (left)	2.25	1	1	2.2	0.00	1.0000	GPX1
High blood pressure	2.24	1	0	0.0	0.00	1.0000	CRHR1-IT1
Alcohol intake versus 10 years previously	2.22	1	0	0.0	0.00	1.0000	GPX1
Sitting height	2.20	1	1	2.2	0.00	1.0000	CRHR1-IT1
Trunk fat mass	2.18	2	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1
Arm predicted mass (left)	2.14	1	1	2.2	0.00	1.0000	GPX1
Hand grip strength (right)	2.13	1	0	0.0	0.00	1.0000	CRHR1-IT1
Heel T-Score	2.10	1	1	2.2	0.00	1.0000	CRHR1-IT1
Hip circumference	2.03	1	1	2.2	0.00	1.0000	GPX1
Hypertension (Self-reported)	2.02	1	0	0.0	0.00	1.0000	CRHR1-IT1
Weight	1.98	1	1	2.2	0.00	1.0000	GPX1
Waist circumference	1.91	1	1	2.2	0.00	1.0000	GPX1
Arm predicted mass (right)	1.91	1	1	2.2	0.00	1.0000	GPX1
Blood White Count	1.90	3	1	2.2	0.00	1.0000	CRHR1-IT1 GPX1 PCCB
Arm fat-free mass (right)	1.84	1	1	2.2	0.00	1.0000	GPX1
Lung FEV1/FVC ratio	1.52	2	0	0.0	0.00	1.0000	CRHR1-IT1 GPX1
Allergy	1.48	1	0	0.0	0.00	1.0000	KCTD10
Basal metabolic rate	1.41	1	1	2.2	0.00	1.0000	GPX1
Trunk fat-free mass	1.36	1	0	0.0	0.00	1.0000	GPX1
Trunk predicted mass	1.33	1	0	0.0	0.00	1.0000	GPX1
Whole body water mass	1.26	1	1	2.2	0.00	1.0000	GPX1
Height	1.25	3	3	6.7	0.00	1.0000	CRHR1-IT1 GPX1 PCCB
Whole body fat-free mass	1.20	1	1	2.2	0.00	1.0000	GPX1
Standing height	1.07	1	0	0.0	0.00	1.0000	GPX1
Blood Platelet Count	1.02	1	1	2.2	0.00	1.0000	PCCB
Leg fat-free mass (left)	1.00	1	0	0.0	0.00	1.0000	GPX1
Leg predicted mass (left)	0.98	1	0	0.0	0.00	1.0000	GPX1
Leg predicted mass (right)	0.82	1	0	0.0	0.00	1.0000	GPX1
Leg fat-free mass (right)	0.81	1	0	0.0	0.00	1.0000	GPX1
Hair Pigment	0.16	1	0	0.0	0.00	1.0000	CRHR1-IT1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Artery Coronary	10	0.845	1.9
GTEx	Brain Hippocampus	5	0.954	1.9
GTEx	Ovary	7	0.771	1.9
GTEx	Pituitary	5	0.448	1.9
GTEx	Small Intestine Terminal Ileum	4	0.868	1.9
GTEx	Uterus	6	1.058	1.9
GTEx	Brain Frontal Cortex BA9	5	0.541	1.8
GTEx	Brain Hypothalamus	4	0.678	1.8
GTEx	Cells EBV-transformed lymphocytes	11	0.773	1.8
GTEx	Heart Left Ventricle	6	0.392	1.8
GTEx	Liver	3	0.418	1.8
GTEx	Adipose Visceral Omentum	6	0.295	1.7
GTEx	Brain Caudate basal ganglia	4	0.435	1.7
GTEx	Brain Cerebellar Hemisphere	6	0.403	1.7
GTEx	Brain Cortex	6	0.580	1.7
GTEx	Brain Nucleus accumbens basal ganglia	5	0.578	1.7
GTEx	Brain Putamen basal ganglia	4	0.641	1.7
GTEx	Breast Mammary Tissue	7	0.355	1.7
GTEx	Colon Sigmoid	8	0.547	1.7
GTEx	Colon Transverse	7	0.339	1.7
GTEx	Esophagus Gastroesophageal Junction	8	0.554	1.7
GTEx	Esophagus Muscularis	11	0.340	1.7
GTEx	Heart Atrial Appendage	6	0.380	1.7
GTEx	Prostate	5	0.599	1.7
GTEx	Skin Not Sun Exposed Suprapubic	8	0.325	1.7
GTEx	Stomach	9	0.619	1.7
GTEx	Vagina	4	0.630	1.7
The Cancer Genome Atlas	Esophageal Carcinoma	4	0.584	1.7
GTEx	Adipose Subcutaneous	9	0.258	1.6
GTEx	Adrenal Gland	5	0.343	1.6
GTEx	Artery Aorta	8	0.269	1.6
GTEx	Artery Tibial	7	0.186	1.6
GTEx	Brain Cerebellum	6	0.303	1.6
GTEx	Breast Mammary Tissue (Male)	7	0.587	1.6
GTEx	Breast Mammary Tissue (Female)	8	0.487	1.6
GTEx	Cells Transformed fibroblasts	8	0.191	1.6
GTEx	Esophagus Mucosa	10	0.301	1.6
GTEx	Lung	10	0.348	1.6
GTEx	Muscle Skeletal	6	0.208	1.6
GTEx	Pancreas	6	0.368	1.6
GTEx	Skin Sun Exposed Lower leg	12	0.330	1.6
GTEx	Spleen	7	0.496	1.6
GTEx	Testis	9	0.285	1.6
GTEx	Thyroid	11	0.275	1.6
GTEx	Whole Blood	4	0.201	1.6
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	2	0.120	1.6
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	3	0.226	1.6
GTEx	Nerve Tibial	8	0.185	1.5
NTR	Blood	3	0.125	1.5
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	4	0.365	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.097	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	3	0.294	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	5	0.184	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	3	0.146	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	6	0.204	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	6	0.239	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	3	0.188	1.5
The Cancer Genome Atlas	Prostate Adenocarcinoma	6	0.130	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	2	0.289	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	3	0.281	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	4	0.238	1.5
The Cancer Genome Atlas	Thyroid Carcinoma	6	0.116	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	2	0.394	1.5
METSIM	Adipose	1	0.022	1.4
YFS	Blood	1	0.022	1.4
CommonMind	Brain Pre-frontal Cortex	4	0.074	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	4	0.091	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	5	0.122	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	3	0.070	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	2	0.181	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	2	0.156	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.3