Hub : Traits :

Frequency of tenseness / restlessness in last 2 weeks

404 significantly associated models · 35 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 43682052 45148674 1 1 1.4e-07 9.8e-07 0.130 90 TCAIM
2 3 48381826 50546340 8 1 1.0e-07 7.0e-07 0.028 80 GPX1
3 3 135273949 136755553 2 1 2.7e-08 6.9e-08 1.000 100 PCCB
4 12 109295508 110704487 2 1 3.4e-08 4.8e-08 0.158 93 KCTD10
5 13 31078511 32595740 1 1 4.6e-09 2.1e-06 0.177 92 B3GALTL
6 17 42607368 45796313 21 1 3.0e-14 6.8e-12 1.000 100 CRHR1-IT1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 17.44 4 3 6.7 1.00 0.0013 CRHR1-IT1 GPX1 KCTD10 PCCB
Depression (Nagel 2018) 9.96 2 1 2.2 0.00 1.0000 CRHR1-IT1 PCCB
Intelligence (Savage-Jansen 2018) 9.35 3 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1 PCCB
Neuroticism (Nagel 2018) 20.60 6 3 6.7 0.97 0.0011 B3GALTL CRHR1-IT1 GPX1 KCTD10 PCCB TCAIM
Schizophrenia (2018) 3.98 1 1 2.2 0.00 1.0000 PCCB
Schizophrenia vs Biploar Disorder 4.89 1 0 0.0 0.00 1.0000 CRHR1-IT1
Worry (Nagel 2018) 13.07 4 3 6.7 0.98 0.0197 B3GALTL CRHR1-IT1 KCTD10 PCCB
Crohns Disease (2017) 5.28 1 1 2.2 0.00 1.0000 GPX1
Irritable Bowel Disease (IBD) 7.17 1 1 2.2 0.00 1.0000 GPX1
Ulcerative Colitis (UC) 6.24 1 1 2.2 0.00 1.0000 GPX1
Major Depression (MDD) 7.42 1 0 0.0 0.00 1.0000 GPX1
Verbal and Numeric Reasoning (VNR) 7.09 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Breast Cancer 5.51 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Ovarian Cancer 5.37 1 1 2.2 0.00 1.0000 CRHR1-IT1
Prostate Cancer 3.92 1 0 0.0 0.00 1.0000 GPX1
Age at First Birth 8.17 1 1 2.2 0.00 1.0000 GPX1
Crohns Disease (2012) 4.26 1 1 2.2 0.00 1.0000 GPX1
HDL Cholesterol 5.34 1 1 2.2 0.00 1.0000 KCTD10
Neuroticism (2016) 10.43 1 1 2.2 0.00 1.0000 CRHR1-IT1
Primary Biliary Cirrhosis 3.02 1 0 0.0 0.00 1.0000 CRHR1-IT1
Schizophrenia (2014) 4.10 1 1 2.2 0.00 1.0000 PCCB
Ulcerative Colitis 5.84 1 1 2.2 0.00 1.0000 GPX1
Blood Eosinophil Count 3.83 2 1 2.2 0.00 1.0000 CRHR1-IT1 KCTD10
Blood Platelet Count 1.02 1 1 2.2 0.00 1.0000 PCCB
Blood Red Count 7.88 1 1 2.2 0.00 1.0000 CRHR1-IT1
Blood White Count 1.90 3 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1 PCCB
Heel T-Score 2.10 1 1 2.2 0.00 1.0000 CRHR1-IT1
BMI 3.47 1 1 2.2 0.00 1.0000 GPX1
Height 1.25 3 3 6.7 0.00 1.0000 CRHR1-IT1 GPX1 PCCB
Waist Hip Ratio (WHR) 4.94 3 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1 PCCB
Systolic Blood Pressure 3.96 2 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1
Smoking Status 3.85 1 1 2.2 0.00 1.0000 GPX1
Lung FEV1/FVC ratio 1.52 2 0 0.0 0.00 1.0000 CRHR1-IT1 GPX1
Lung FVC 7.50 2 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1
Neuroticism 18.74 5 4 8.9 0.98 0.0033 B3GALTL CRHR1-IT1 GPX1 KCTD10 PCCB
Hair Pigment 0.16 1 0 0.0 0.00 1.0000 CRHR1-IT1
Hand grip strength (left) 2.54 1 1 2.2 0.00 1.0000 CRHR1-IT1
Number of treatments/medications taken 4.51 1 1 2.2 0.00 1.0000 GPX1
Sensitivity / hurt feelings 13.81 3 2 4.4 0.00 1.0000 CRHR1-IT1 KCTD10 PCCB
Frequency of depressed mood in last 2 weeks 9.35 2 0 0.0 0.00 1.0000 CRHR1-IT1 PCCB
Hearing difficulty/problems: Yes 4.05 1 0 0.0 0.00 1.0000 KCTD10
Relative age of first facial hair 9.55 1 1 2.2 0.00 1.0000 CRHR1-IT1
Systolic blood pressure, automated reading 5.02 2 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1
Medication: Co-codamol 3.99 1 0 0.0 0.00 1.0000 GPX1
Pack years adult smoking proportion 3.80 1 0 0.0 0.00 1.0000 GPX1
Impedance of leg (right) 2.37 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Leg fat-free mass (left) 1.00 1 0 0.0 0.00 1.0000 GPX1
Trunk fat percentage 2.56 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Hand grip strength (right) 2.13 1 0 0.0 0.00 1.0000 CRHR1-IT1
Fed-up feelings 14.51 3 3 6.7 0.00 1.0000 CRHR1-IT1 GPX1 PCCB
Frequency of unenthusiasm / disinterest in last 2 weeks 8.42 2 0 0.0 0.00 1.0000 GPX1 PCCB
Relative age voice broke 6.83 1 1 2.2 0.00 1.0000 CRHR1-IT1
Taking other prescription medications 4.26 1 1 2.2 0.00 1.0000 GPX1
Age when periods started (menarche) 4.67 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Qualifications: CSEs or equivalent 4.74 1 0 0.0 0.00 1.0000 GPX1
High blood pressure 2.24 1 0 0.0 0.00 1.0000 CRHR1-IT1
Stomach or abdominal pain in last month 4.84 1 0 0.0 0.00 1.0000 PCCB
Sitting height 2.20 1 1 2.2 0.00 1.0000 CRHR1-IT1
Body mass index (BMI) 4.21 1 1 2.2 0.00 1.0000 GPX1
Impedance of leg (left) 2.55 2 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1
Leg predicted mass (left) 0.98 1 0 0.0 0.00 1.0000 GPX1
Trunk fat mass 2.18 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Waist circumference 1.91 1 1 2.2 0.00 1.0000 GPX1
Nervous feelings 10.56 3 2 4.4 0.00 1.0000 CRHR1-IT1 KCTD10 PCCB
Hearing difficulty/problems with background noise 4.86 2 0 0.0 0.00 1.0000 CRHR1-IT1 KCTD10
Hair/balding pattern: Pattern 2 3.63 1 0 0.0 0.00 1.0000 CRHR1-IT1
Forced vital capacity (FVC) 6.03 2 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1
Ever unenthusiastic/disinterested for a whole week 5.78 1 0 0.0 0.00 1.0000 CRHR1-IT1
Qualifications: None of the above 6.26 1 1 2.2 0.00 1.0000 GPX1
Mouth/teeth dental problems 4.72 2 0 0.0 0.00 1.0000 CRHR1-IT1 KCTD10
Allergy 1.48 1 0 0.0 0.00 1.0000 KCTD10
Pain all over the body in last month 3.99 1 0 0.0 0.00 1.0000 GPX1
Fluid intelligence score 6.68 2 1 2.2 0.00 1.0000 GPX1 PCCB
Neuroticism score 17.25 5 4 8.9 0.99 0.0012 B3GALTL CRHR1-IT1 GPX1 KCTD10 PCCB
Weight 1.98 1 1 2.2 0.00 1.0000 GPX1
Impedance of arm (right) 5.66 2 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1
Arm fat percentage (right) 2.54 1 1 2.2 0.00 1.0000 GPX1
Trunk fat-free mass 1.36 1 0 0.0 0.00 1.0000 GPX1
Hip circumference 2.03 1 1 2.2 0.00 1.0000 GPX1
Time employed in main current job 3.04 1 0 0.0 0.00 1.0000 CRHR1-IT1
Alcohol intake versus 10 years previously 2.22 1 0 0.0 0.00 1.0000 GPX1
Father's age at death 3.74 1 0 0.0 0.00 1.0000 GPX1
Worrier / anxious feelings 10.20 3 2 4.4 0.00 1.0000 CRHR1-IT1 KCTD10 PCCB
Frequency of tiredness / lethargy in last 2 weeks 12.40 4 1 2.2 0.98 0.0247 GPX1 KCTD10 PCCB TCAIM
Hair/balding pattern: Pattern 3 8.95 1 1 2.2 0.00 1.0000 CRHR1-IT1
Forced expiratory volume in 1-second (FEV1) 7.14 2 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1
Qualifications: A levels/AS levels or equivalent 8.72 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Mouth/teeth dental problems: Dentures 4.28 1 0 0.0 0.00 1.0000 GPX1
Medication: Ibuprofen (e.g. Nurofen) 4.23 1 0 0.0 0.00 1.0000 CRHR1-IT1
Depression (self-reported) 4.15 1 0 0.0 0.00 1.0000 B3GALTL
Forced expiratory volume in 1-second (FEV1), Best measure 6.53 2 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1
Impedance of arm (left) 6.94 3 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1 TCAIM
Arm fat mass (right) 2.78 1 1 2.2 0.00 1.0000 GPX1
Trunk predicted mass 1.33 1 0 0.0 0.00 1.0000 GPX1
Standing height 1.07 1 0 0.0 0.00 1.0000 GPX1
Exposure to tobacco smoke at home 3.36 1 0 0.0 0.00 1.0000 GPX1
Tense / 'highly strung' 6.81 1 0 0.0 0.00 1.0000 PCCB
Seen doctor (GP) for nerves, anxiety, tension or depression 6.29 2 1 2.2 0.00 1.0000 B3GALTL TCAIM
Hair/balding pattern: Pattern 4 16.90 1 1 2.2 0.00 1.0000 CRHR1-IT1
Peak expiratory flow (PEF) 3.92 2 1 2.2 0.00 1.0000 CRHR1-IT1 KCTD10
Ever highly irritable/argumentative for 2 days 5.64 1 0 0.0 0.00 1.0000 GPX1
Qualifications: O levels/GCSEs or equivalent 3.41 1 0 0.0 0.00 1.0000 GPX1
Medication: Paracetamol 9.98 3 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1 KCTD10
Headache pain in last month 10.04 1 1 2.2 0.00 1.0000 CRHR1-IT1
Forced vital capacity (FVC), Best measure 6.03 2 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1
Body fat percentage 2.65 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Leg fat percentage (right) 4.13 1 1 2.2 0.00 1.0000 GPX1
Arm fat-free mass (right) 1.84 1 1 2.2 0.00 1.0000 GPX1
Number of full brothers 4.10 1 0 0.0 0.00 1.0000 GPX1
Worry too long after embarrassment 10.00 3 1 2.2 0.00 1.0000 CRHR1-IT1 KCTD10 PCCB
Wheeze or whistling in the chest in last year 3.52 1 0 0.0 0.00 1.0000 GPX1
Age at first live birth 7.41 1 1 2.2 0.00 1.0000 GPX1
Health satisfaction 3.19 1 0 0.0 0.00 1.0000 GPX1
Qualifications: College or University degree 11.82 3 3 6.7 0.00 1.0000 B3GALTL CRHR1-IT1 GPX1
Medication for pain relief, constipation, heartburn 5.81 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Neck or shoulder pain in last month 4.70 1 0 0.0 0.00 1.0000 GPX1
Medication: Ibuprofen 4.39 1 0 0.0 0.00 1.0000 CRHR1-IT1
Whole body fat mass 2.71 1 1 2.2 0.00 1.0000 GPX1
Leg fat mass (right) 3.72 1 1 2.2 0.00 1.0000 GPX1
Arm predicted mass (right) 1.91 1 1 2.2 0.00 1.0000 GPX1
Alcohol intake frequency. 4.27 1 1 2.2 0.00 1.0000 CRHR1-IT1
Comparative height size at age 10 2.45 4 0 0.0 -1.00 0.0025 CRHR1-IT1 GPX1 KCTD10 PCCB
Suffer from 'nerves' 5.88 1 0 0.0 0.00 1.0000 CRHR1-IT1
Overall health rating 6.49 1 1 2.2 0.00 1.0000 GPX1
Age at last live birth 6.47 1 1 2.2 0.00 1.0000 GPX1
Leg pain on walking 5.07 1 0 0.0 0.00 1.0000 GPX1
Hypertension (Self-reported) 2.02 1 0 0.0 0.00 1.0000 CRHR1-IT1
Whole body fat-free mass 1.20 1 1 2.2 0.00 1.0000 GPX1
Leg fat-free mass (right) 0.81 1 0 0.0 0.00 1.0000 GPX1
Arm fat percentage (left) 2.48 1 1 2.2 0.00 1.0000 GPX1
Handedness (chirality/laterality): Left-handed 4.02 1 0 0.0 0.00 1.0000 CRHR1-IT1
Mood swings 14.40 4 2 4.4 1.00 0.0025 CRHR1-IT1 GPX1 KCTD10 TCAIM
Loneliness, isolation 7.21 2 0 0.0 0.00 1.0000 CRHR1-IT1 GPX1
Qualifications: nursing, teaching 5.08 1 0 0.0 0.00 1.0000 GPX1
Mouth/teeth dental problems: Mouth ulcers 5.34 1 1 2.2 0.00 1.0000 CRHR1-IT1
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.01 1 1 2.2 0.00 1.0000 CRHR1-IT1
Whole body water mass 1.26 1 1 2.2 0.00 1.0000 GPX1
Leg predicted mass (right) 0.82 1 0 0.0 0.00 1.0000 GPX1
Arm fat mass (left) 2.62 1 1 2.2 0.00 1.0000 GPX1
Average weekly champagne plus white wine intake 4.27 1 0 0.0 0.00 1.0000 CRHR1-IT1
Miserableness 15.60 5 2 4.4 0.98 0.0035 B3GALTL CRHR1-IT1 GPX1 KCTD10 PCCB
Guilty feelings 8.53 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Financial situation satisfaction 5.35 1 1 2.2 0.00 1.0000 GPX1
Medication: Blood pressure 3.41 1 0 0.0 0.00 1.0000 CRHR1-IT1
Medication: Paracetamol 9.77 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Basal metabolic rate 1.41 1 1 2.2 0.00 1.0000 GPX1
Leg fat percentage (left) 4.07 1 1 2.2 0.00 1.0000 GPX1
Arm fat-free mass (left) 2.25 1 1 2.2 0.00 1.0000 GPX1
Irritability 6.71 2 1 2.2 0.00 1.0000 CRHR1-IT1 KCTD10
Risk taking 3.11 1 0 0.0 0.00 1.0000 PCCB
Age started oral contraceptive pill 3.32 1 0 0.0 0.00 1.0000 GPX1
Diastolic blood pressure, automated reading 3.74 2 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1
Commuting to job workplace: Cycle 3.42 1 0 0.0 0.00 1.0000 TCAIM
Pain experienced in last month 7.87 3 1 2.2 0.00 1.0000 CRHR1-IT1 GPX1 KCTD10
Pack years of smoking 2.90 1 0 0.0 0.00 1.0000 GPX1
Impedance of whole body 4.79 2 2 4.4 0.00 1.0000 CRHR1-IT1 GPX1
Leg fat mass (left) 3.75 1 1 2.2 0.00 1.0000 GPX1
Arm predicted mass (left) 2.14 1 1 2.2 0.00 1.0000 GPX1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.258 1.6
GTEx Adipose Visceral Omentum 6 0.295 1.7
GTEx Adrenal Gland 5 0.343 1.6
GTEx Artery Aorta 8 0.269 1.6
GTEx Artery Coronary 10 0.845 1.9
GTEx Artery Tibial 7 0.186 1.6
GTEx Brain Caudate basal ganglia 4 0.435 1.7
GTEx Brain Cerebellar Hemisphere 6 0.403 1.7
GTEx Brain Cerebellum 6 0.303 1.6
GTEx Brain Cortex 6 0.580 1.7
GTEx Brain Frontal Cortex BA9 5 0.541 1.8
GTEx Brain Hippocampus 5 0.954 1.9
GTEx Brain Hypothalamus 4 0.678 1.8
GTEx Brain Nucleus accumbens basal ganglia 5 0.578 1.7
GTEx Brain Putamen basal ganglia 4 0.641 1.7
GTEx Breast Mammary Tissue 7 0.355 1.7
GTEx Breast Mammary Tissue (Male) 7 0.587 1.6
GTEx Breast Mammary Tissue (Female) 8 0.487 1.6
GTEx Cells EBV-transformed lymphocytes 11 0.773 1.8
GTEx Cells Transformed fibroblasts 8 0.191 1.6
GTEx Colon Sigmoid 8 0.547 1.7
GTEx Colon Transverse 7 0.339 1.7
GTEx Esophagus Gastroesophageal Junction 8 0.554 1.7
GTEx Esophagus Mucosa 10 0.301 1.6
GTEx Esophagus Muscularis 11 0.340 1.7
GTEx Heart Atrial Appendage 6 0.380 1.7
GTEx Heart Left Ventricle 6 0.392 1.8
GTEx Liver 3 0.418 1.8
GTEx Lung 10 0.348 1.6
GTEx Muscle Skeletal 6 0.208 1.6
GTEx Nerve Tibial 8 0.185 1.5
GTEx Ovary 7 0.771 1.9
GTEx Pancreas 6 0.368 1.6
GTEx Pituitary 5 0.448 1.9
GTEx Prostate 5 0.599 1.7
GTEx Skin Not Sun Exposed Suprapubic 8 0.325 1.7
GTEx Skin Sun Exposed Lower leg 12 0.330 1.6
GTEx Small Intestine Terminal Ileum 4 0.868 1.9
GTEx Spleen 7 0.496 1.6
GTEx Stomach 9 0.619 1.7
GTEx Testis 9 0.285 1.6
GTEx Thyroid 11 0.275 1.6
GTEx Uterus 6 1.058 1.9
GTEx Vagina 4 0.630 1.7
GTEx Whole Blood 4 0.201 1.6
METSIM Adipose 1 0.022 1.4
NTR Blood 3 0.125 1.5
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.5
YFS Blood 1 0.022 1.4
CommonMind Brain Pre-frontal Cortex 4 0.074 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 2 0.121 1.5
The Cancer Genome Atlas Breast Invasive Carcinoma 4 0.091 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 4 0.365 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 2 0.097 1.5
The Cancer Genome Atlas Esophageal Carcinoma 4 0.584 1.7
The Cancer Genome Atlas Glioblastoma Multiforme 3 0.294 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 5 0.184 1.5
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 5 0.122 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 3 0.146 1.5
The Cancer Genome Atlas Brain Lower Grade Glioma 3 0.070 1.4
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 2 0.181 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 6 0.204 1.5
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 6 0.239 1.5
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 3 0.188 1.5
The Cancer Genome Atlas Pancreatic Adenocarcinoma 2 0.120 1.6
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 3 0.226 1.6
The Cancer Genome Atlas Prostate Adenocarcinoma 6 0.130 1.5
The Cancer Genome Atlas Rectum Adenocarcinoma 2 0.289 1.5
The Cancer Genome Atlas Soft Tissue Sarcoma 3 0.281 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.187 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 4 0.238 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 2 0.156 1.4
The Cancer Genome Atlas Thyroid Carcinoma 6 0.116 1.5
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 2 0.394 1.5