Best TWAS P=3.36e-08 · Best GWAS P=4.76e-08 conditioned to 0.158
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MMAB | 0.12 | 0.09 | enet | 13 | 0.08 | 2.9e-10 | 5.1 | -5.2 | 1.8e-07 | -0.66 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | MMAB | 0.07 | 0.06 | enet | 9 | 0.05 | 7.3e-05 | 4.8 | -5.3 | 1.2e-07 | -0.89 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Thyroid | MMAB | 0.07 | 0.00 | lasso | 6 | 0.02 | 5.4e-03 | -4.3 | -5.5 | 3.4e-08 | -0.76 | 0.05 | 0.85 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MMAB | 0.03 | 0.01 | blup | 57 | 0.02 | 6.5e-06 | 5.1 | -5.2 | 2.0e-07 | -0.55 | 0.02 | 0.92 | FALSE |
| 5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MMAB | 0.05 | 0.01 | blup | 57 | 0.02 | 5.8e-02 | 5.0 | -5.4 | 5.5e-08 | -0.61 | 0.02 | 0.69 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MMAB | 0.03 | 0.02 | blup | 57 | 0.02 | 2.2e-03 | 4.6 | -5.4 | 5.7e-08 | -0.74 | 0.04 | 0.63 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MMAB | 0.04 | 0.02 | blup | 53 | 0.02 | 5.2e-03 | 5.1 | -5.2 | 2.5e-07 | -0.62 | 0.01 | 0.58 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MMAB | 0.09 | 0.05 | blup | 57 | 0.09 | 6.3e-06 | 5.1 | -5.5 | 4.9e-08 | -0.64 | 0.05 | 0.83 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | MMAB | 0.03 | 0.02 | blup | 57 | 0.02 | 2.4e-03 | 5.1 | -5.2 | 2.1e-07 | -0.48 | 0.02 | 0.77 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | KCTD10 | 0.15 | 0.08 | lasso | 6 | 0.08 | 2.1e-08 | 5.2 | -5.5 | 3.4e-08 | -0.86 | 0.01 | 0.99 | TRUE |