TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Body mass index (BMI)
:
←
→
chr1:71,163,715-73,435,171
Best TWAS P=2.46e-17 · Best GWAS P=2.96e-24 conditioned to 3.84e-12
71.5M
72M
72.5M
73M
73.5M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
NEGR1
0.24
0.15
lasso
8
0.22
1.3e-27
5.8
8.5
2.5e-17
-0.48
1.00
0.0
TRUE
1
GTEx
Esophagus Muscularis
NEGR1
0.13
0.04
lasso
3
0.05
5.1e-04
-6.4
7.0
3.1e-12
-0.66
0.73
0.1
FALSE