Best TWAS P=2.51e-09 · Best GWAS P=1.22e-10 conditioned to 0.0139
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | HMGB1 | 0.26 | 0.02 | lasso | 6 | 0.03 | 9.1e-03 | -6.4 | 6.0 | 2.5e-09 | -0.90 | 0.00 | 0.97 | TRUE |
| 2 | GTEx | Muscle Skeletal | HMGB1 | 0.21 | 0.05 | lasso | 6 | 0.08 | 7.1e-08 | -5.3 | 5.5 | 3.2e-08 | -0.74 | 0.04 | 0.95 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HMGB1 | 0.08 | 0.04 | lasso | 1 | 0.04 | 6.9e-05 | -5.9 | 5.9 | 4.8e-09 | -0.78 | 0.03 | 0.95 | FALSE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HMGB1 | 0.10 | 0.07 | lasso | 4 | 0.06 | 1.4e-06 | -5.3 | 5.5 | 4.7e-08 | -0.80 | 0.15 | 0.85 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | HMGB1 | 0.07 | 0.06 | lasso | 1 | 0.05 | 1.2e-05 | -5.3 | 5.3 | 1.3e-07 | -0.79 | 0.03 | 0.96 | FALSE |