Best TWAS P=4.52e-11 · Best GWAS P=5.91e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-298P3.4 | 0.09 | 0.01 | lasso | 7 | 0.00 | 1.9e-01 | -5.9 | -6.2 | 5.6e-10 | 0.84 | 0.06 | 0.87 | FALSE |
| 2 | GTEx | Artery Aorta | N4BP2L2 | 0.13 | 0.10 | lasso | 3 | 0.09 | 1.1e-05 | -6.5 | -6.3 | 3.3e-10 | 0.98 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Whole Blood | KL | 0.12 | 0.00 | lasso | 7 | 0.00 | 4.9e-01 | -2.7 | 5.9 | 4.8e-09 | -0.58 | 0.12 | 0.17 | FALSE |
| 4 | YFS | Blood | PDS5B | 0.03 | 0.04 | lasso | 1 | 0.03 | 1.4e-11 | -5.3 | -5.3 | 1.4e-07 | 0.81 | 0.29 | 0.71 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CG030 | 0.04 | 0.01 | lasso | 3 | 0.02 | 2.1e-04 | -6.5 | 6.3 | 3.2e-10 | -0.97 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | N4BP2L2 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.4e-03 | -6.5 | -6.4 | 1.7e-10 | 1.00 | 0.01 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CG030 | 0.07 | 0.02 | lasso | 4 | 0.03 | 2.4e-04 | -6.1 | 5.8 | 6.4e-09 | -0.83 | 0.01 | 0.66 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | N4BP2L2 | 0.04 | 0.03 | blup | 69 | 0.02 | 9.4e-04 | -6.5 | -6.0 | 2.1e-09 | 0.97 | 0.01 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CG030 | 0.06 | 0.01 | blup | 38 | 0.02 | 1.9e-03 | 3.4 | 5.3 | 9.0e-08 | -0.82 | 0.02 | 0.89 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | N4BP2L2 | 0.10 | 0.10 | lasso | 4 | 0.11 | 5.2e-12 | -6.5 | -6.1 | 1.1e-09 | 0.97 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | N4BP2L2 | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.5e-04 | -6.5 | -6.6 | 4.5e-11 | 0.99 | 0.00 | 0.99 | TRUE |
| 12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CG030 | 0.08 | 0.04 | blup | 38 | 0.04 | 1.4e-03 | -6.1 | 6.1 | 8.4e-10 | -0.92 | 0.00 | 0.91 | FALSE |
| 13 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CG030 | 0.12 | 0.02 | blup | 38 | 0.03 | 3.1e-02 | -6.1 | 6.1 | 1.1e-09 | -0.82 | 0.00 | 0.59 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | N4BP2L2 | 0.06 | 0.03 | lasso | 3 | 0.05 | 1.0e-05 | 4.8 | -5.9 | 2.7e-09 | 0.79 | 0.02 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | N4BP2L2 | 0.12 | 0.14 | enet | 7 | 0.16 | 1.1e-15 | -5.8 | -6.3 | 2.7e-10 | 0.98 | 0.01 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | PDS5B | 0.02 | 0.01 | blup | 78 | 0.02 | 1.2e-02 | -6.0 | 5.8 | 5.1e-09 | -0.92 | 0.02 | 0.78 | FALSE |