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chr15:65,989,359-68,789,191

Best TWAS P=1.15e-18 · Best GWAS P=3.51e-23 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Muscle Skeletal	MAP2K5	0.08	0.03	lasso	6	0.05	1.9e-05	6.7	8.8	1.2e-18	-0.91	0.01	0.99	TRUE
21	METSIM	Adipose	MAP2K5	0.07	0.05	enet	19	0.06	2.8e-09	-9.2	8.7	5.2e-18	-0.60	0.24	0.76	TRUE
6	GTEx	Artery Tibial	MAP2K5	0.15	0.18	lasso	3	0.18	6.3e-14	-7.8	7.8	6.7e-15	-0.66	1.00	0.00	TRUE
32	The Cancer Genome Atlas	Soft Tissue Sarcoma	LBXCOR1	0.07	0.03	blup	57	0.03	6.3e-03	-7.3	5.8	8.1e-09	-0.65	0.04	0.09	TRUE
7	GTEx	Brain Cerebellum	MAP2K5	0.27	0.12	lasso	5	0.14	7.9e-05	-3.2	5.7	9.3e-09	-0.54	0.37	0.26	TRUE
23	YFS	Blood	MAP2K1	0.07	0.05	lasso	3	0.05	2.0e-17	-4.8	5.2	1.5e-07	0.05	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	MAP2K1	0.09	0.05	lasso	4	0.05	2.2e-06	4.9	5.2	1.7e-07	-0.06	0.66	0.07	TRUE
11	GTEx	Heart Atrial Appendage	MAP2K5	0.16	0.08	lasso	5	0.16	1.3e-07	-7.7	8.3	1.3e-16	-0.80	0.09	0.91	FALSE
4	GTEx	Adipose Visceral Omentum	MAP2K5	0.07	0.08	lasso	3	0.05	1.0e-03	-7.8	8.2	2.3e-16	-0.65	0.12	0.81	FALSE
9	GTEx	Breast Mammary Tissue	MAP2K5	0.14	0.07	lasso	5	0.09	2.8e-05	-9.3	8.1	5.6e-16	-0.62	0.10	0.90	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP2K5	0.03	0.03	blup	142	0.02	1.6e-03	-7.8	8.0	9.9e-16	-0.53	0.14	0.78	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	MAP2K5	0.04	0.04	lasso	3	0.03	8.7e-05	-7.8	7.9	1.9e-15	-0.66	0.25	0.68	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	MAP2K5	0.10	0.06	lasso	5	0.04	6.1e-05	-7.8	7.9	2.1e-15	-0.64	0.77	0.18	FALSE
12	GTEx	Heart Left Ventricle	MAP2K5	0.10	0.10	lasso	3	0.10	9.4e-06	-7.8	7.9	2.7e-15	-0.66	0.77	0.16	FALSE
15	GTEx	Nerve Tibial	MAP2K5	0.19	0.21	lasso	2	0.20	3.3e-14	-7.8	7.8	7.2e-15	-0.66	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	MAP2K5	0.14	0.18	lasso	4	0.18	1.0e-14	-7.8	7.8	8.4e-15	-0.66	1.00	0.00	FALSE
19	GTEx	Thyroid	MAP2K5	0.11	0.16	lasso	4	0.15	9.6e-12	-7.8	7.7	9.5e-15	-0.68	0.99	0.01	FALSE
5	GTEx	Artery Aorta	MAP2K5	0.06	0.05	enet	6	0.05	7.7e-04	-7.8	7.7	1.2e-14	-0.65	0.42	0.36	FALSE
10	GTEx	Esophagus Muscularis	MAP2K5	0.24	0.14	lasso	4	0.13	2.1e-08	-7.8	7.6	2.5e-14	-0.65	1.00	0.00	FALSE
24	YFS	Blood	MAP2K5	0.05	0.07	lasso	4	0.07	1.2e-21	-7.8	7.6	3.0e-14	-0.63	1.00	0.00	FALSE
16	GTEx	Ovary	MAP2K5	0.19	0.24	lasso	3	0.21	8.3e-06	-7.8	7.6	3.5e-14	-0.65	0.19	0.56	FALSE
20	GTEx	Whole Blood	MAP2K5	0.09	0.06	lasso	6	0.06	8.1e-06	-7.8	7.2	5.0e-13	-0.64	0.69	0.18	FALSE
17	GTEx	Skin Sun Exposed Lower leg	MAP2K5	0.13	0.06	lasso	4	0.09	4.4e-08	4.8	7.1	1.6e-12	-0.73	0.84	0.16	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MAP2K5	0.11	0.07	bslmm	474	0.08	1.2e-09	-7.8	7.0	3.3e-12	-0.53	0.97	0.03	FALSE
13	GTEx	Lung	MAP2K5	0.12	0.09	enet	11	0.07	3.6e-06	-7.7	6.8	1.4e-11	-0.60	0.96	0.02	FALSE
18	GTEx	Spleen	MAP2K5	0.25	0.19	lasso	3	0.18	2.1e-05	-7.8	6.5	6.7e-11	-0.45	0.15	0.71	FALSE
30	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCH	0.04	0.02	enet	6	0.03	1.6e-04	-7.8	6.4	1.4e-10	-0.63	0.01	0.98	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	LBXCOR1	0.06	0.01	lasso	3	0.03	7.0e-04	-6.2	6.3	3.6e-10	-0.43	0.10	0.49	FALSE
8	GTEx	Brain Hippocampus	IQCH-AS1	0.20	0.08	enet	11	0.05	2.2e-02	4.8	-6.3	3.8e-10	0.74	0.13	0.29	FALSE
22	NTR	Blood	MAP2K5	0.02	0.00	enet	13	0.01	5.7e-04	-7.3	6.2	4.2e-10	-0.60	0.44	0.47	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	IQCH	0.04	0.02	enet	8	0.01	1.6e-02	-6.2	6.2	4.5e-10	-0.71	0.12	0.11	FALSE
31	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IQCH	0.11	0.10	blup	112	0.10	2.3e-07	-6.2	5.6	2.4e-08	-0.71	0.06	0.94	FALSE
27	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	IQCH	0.10	0.01	blup	111	0.03	1.4e-02	6.0	5.6	2.8e-08	-0.72	0.05	0.24	FALSE
25	The Cancer Genome Atlas	Glioblastoma Multiforme	IQCH	0.19	0.14	enet	21	0.12	2.4e-04	-3.5	5.5	3.4e-08	-0.66	0.13	0.76	FALSE