Hub : Genes

IQCH-AS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1580 0.0410 4.4e-10 0.123 NA 0.127 NA 0.133 2.8e-10 NA 1.6e-10 NA 5.1e-11
2 GTEx Adipose Visceral Omentum 0.0880 0.0380 2.4e-03 0.036 NA 0.024 NA 0.026 6.0e-03 NA 2.0e-02 NA 1.7e-02
3 GTEx Adrenal Gland 0.1055 0.0488 8.1e-03 -0.003 NA 0.005 NA 0.014 4.5e-01 NA 2.0e-01 NA 9.9e-02
4 GTEx Artery Aorta 0.2190 0.0570 2.1e-09 0.130 NA 0.164 NA 0.178 1.3e-07 NA 2.4e-09 NA 4.2e-10
5 GTEx Artery Coronary 0.3290 0.0890 4.7e-07 0.119 NA 0.129 NA 0.138 8.3e-05 NA 4.2e-05 NA 2.2e-05
6 GTEx Artery Tibial 0.1531 0.0395 7.1e-11 0.127 NA 0.134 NA 0.179 3.5e-10 NA 1.2e-10 NA 5.6e-14
7 GTEx Brain Cerebellar Hemisphere 0.1800 0.0760 1.3e-03 0.174 NA 0.006 NA 0.145 3.2e-05 NA 2.2e-01 NA 1.5e-04
8 GTEx Brain Cerebellum 0.2650 0.0920 2.5e-04 0.045 NA 0.029 NA 0.100 1.8e-02 NA 4.9e-02 NA 7.1e-04
9 GTEx Brain Hippocampus 0.2022 0.0812 1.4e-03 0.078 NA 0.053 NA 0.000 6.9e-03 NA 2.2e-02 NA 3.3e-01
10 GTEx Breast Mammary Tissue 0.1180 0.0450 8.6e-04 0.096 NA 0.048 NA 0.048 1.2e-05 NA 1.7e-03 NA 1.7e-03
11 GTEx Cells Transformed fibroblasts 0.1680 0.0480 9.9e-09 0.135 NA 0.116 NA 0.139 2.8e-10 NA 4.9e-09 NA 1.5e-10
12 GTEx Colon Sigmoid 0.4440 0.0860 1.2e-09 0.305 NA 0.261 NA 0.310 2.2e-11 NA 9.1e-10 NA 1.4e-11
13 GTEx Colon Transverse 0.2410 0.0730 1.6e-05 0.014 NA 0.077 NA 0.026 6.7e-02 NA 1.5e-04 NA 2.1e-02
14 GTEx Esophagus Muscularis 0.2230 0.0500 2.5e-14 0.246 NA 0.269 NA 0.277 4.4e-15 NA 1.5e-16 NA 4.2e-17
15 GTEx Heart Atrial Appendage 0.1860 0.0610 8.3e-05 0.062 NA 0.092 NA 0.074 9.4e-04 NA 6.4e-05 NA 3.3e-04
16 GTEx Heart Left Ventricle 0.0877 0.0412 3.7e-03 0.010 NA 0.003 NA 0.013 9.3e-02 NA 2.1e-01 NA 6.5e-02
17 GTEx Lung 0.2103 0.0435 1.1e-14 0.243 NA 0.200 NA 0.221 1.4e-18 NA 2.8e-15 NA 7.4e-17
18 GTEx Muscle Skeletal 0.0812 0.0270 8.2e-06 0.040 NA 0.031 NA 0.036 7.7e-05 NA 4.5e-04 NA 1.7e-04
19 GTEx Nerve Tibial 0.1811 0.0459 3.2e-10 0.153 NA 0.127 NA 0.175 5.5e-11 NA 2.7e-09 NA 1.8e-12
20 GTEx Ovary 0.2870 0.0950 1.3e-04 0.074 NA 0.042 NA 0.048 7.0e-03 NA 3.4e-02 NA 2.5e-02
21 GTEx Pituitary 0.4140 0.1090 1.2e-05 0.220 NA 0.261 NA 0.249 3.2e-06 NA 2.9e-07 NA 6.2e-07
22 GTEx Skin Sun Exposed Lower leg 0.1160 0.0490 3.2e-03 0.024 NA 0.020 NA 0.021 3.8e-03 NA 7.8e-03 NA 7.2e-03
23 GTEx Small Intestine Terminal Ileum 0.3000 0.1020 2.6e-04 0.203 NA 0.148 NA 0.176 2.7e-05 NA 3.6e-04 NA 9.7e-05
24 GTEx Spleen 0.3980 0.0890 1.5e-08 0.344 NA 0.456 NA 0.466 1.2e-09 NA 3.2e-13 NA 1.5e-13
25 GTEx Whole Blood 0.0470 0.0230 5.2e-03 0.026 NA 0.021 NA 0.034 1.9e-03 NA 4.6e-03 NA 3.9e-04
26 METSIM Adipose 0.1938 0.0385 0.0e+00 0.259 0.26 0.271 0.268 0.271 1.4e-38 1.1e-38 1.7e-40 5.5e-40 1.5e-40

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26
Bipolar Disorder (2018) 3.6 5.6 7.7 -2.7 -2.6 -2.1 -2.8 -2.4 -2.6 -2.8 -2.0 -2.6 -2.1 -2.5 -2.1 -2.5 -2.7 -2.7 -2.3 -2.7 -2.1 -2.4 -2.1 2.4 0.6 -1.8 -2.5 -2.0 -2.7
Bipolar Disorder or Schizophrenia 1.4 3.3 7.7 -1.9 -1.8 -1.4 -2.0 -2.1 -2.1 -1.6 -1.4 -2.8 -1.2 -2.1 -1.5 -1.8 -2.0 -1.4 -1.5 -2.3 -1.9 -2.0 -1.9 1.3 0.6 -1.5 -2.0 -1.6 -2.5
Depressed Affect (Nagel 2018) 0.8 1.7 6.8 -1.1 -1.2 -1.5 -1.2 -1.2 -1.3 -1.5 -1.6 1.6 -2.6 -1.2 -1.5 -1.8 -0.9 -0.5 -1.1 -0.2 -1.2 -1.4 -0.9 1.0 -1.4 -1.5 -1.5 -1.0 -0.3
Depression (Nagel 2018) 0.3 0.4 3.8 -0.3 -0.3 -0.6 -0.4 -0.6 -0.6 -0.5 -1.2 2.0 -1.6 -0.1 -0.3 -0.1 -0.4 0.2 -0.1 -0.0 -0.3 -0.5 -0.2 0.4 -0.5 -0.2 -0.7 -0.2 -0.0
Intelligence (Savage-Jansen 2018) 0.6 1.8 4.3 -1.7 -1.7 -0.6 -1.3 -1.0 -1.0 -1.9 -0.8 -1.3 -0.5 -0.9 -1.1 -2.0 -1.5 -2.1 -1.4 -1.5 -1.3 -1.0 -1.4 1.7 1.3 -1.1 -0.8 -0.9 -1.7
Neuroticism (Nagel 2018) 0.9 2.1 9.5 -1.2 -1.2 -1.2 -1.3 -1.3 -1.5 -1.1 -1.5 3.1 -3.0 -1.3 -1.5 -1.0 -1.1 0.0 -1.3 -0.5 -1.5 -1.6 -1.2 1.1 -0.8 -1.6 -1.7 -1.2 -0.7
Schizophrenia (2018) 0.2 0.3 2.6 -0.2 -0.2 -0.1 -0.4 -0.8 -0.6 0.1 -0.2 -1.6 0.1 -0.7 -0.2 -0.3 -0.4 0.4 -0.1 -0.8 -0.7 -0.6 -0.7 -0.2 0.3 -0.5 -0.6 -0.4 -1.0
Schizophrenia vs Biploar Disorder 0.0 0.1 0.8 0.1 -0.1 0.3 -0.0 0.2 -0.1 0.2 0.2 0.1 0.2 -0.1 0.0 0.4 0.1 0.2 -0.4 0.0 -0.3 -0.0 -0.1 0.0 0.9 -0.1 -0.1 0.1 -0.3
Worry (Nagel 2018) 0.4 0.8 8.4 -0.6 -0.7 -0.4 -0.7 -0.4 -0.8 -0.5 -0.4 2.9 -1.9 -0.9 -0.6 -0.5 -0.6 0.7 -0.7 -0.6 -0.8 -0.8 -0.8 0.4 -0.3 -0.7 -0.9 -0.9 -0.5
Alzheimer’s Disease (in mother) 0.6 0.7 2.5 0.8 1.0 0.2 0.7 0.6 0.5 0.8 1.0 -0.3 0.9 0.9 1.6 1.0 0.4 0.1 0.6 0.0 1.1 0.8 1.1 -0.4 1.1 1.5 0.6 1.1 0.2
Alzheimer’s Disease (in father) 0.4 0.4 2.5 0.7 0.5 -0.1 0.8 0.4 0.8 0.7 0.5 -0.5 0.4 0.5 0.2 -0.4 0.9 -0.5 0.7 1.2 0.2 0.5 0.2 -0.5 -1.6 -0.2 0.7 -0.0 0.8
Alzheimer’s Disease (including proxy) 0.8 1.1 2.2 1.4 1.4 0.6 1.3 0.7 1.1 1.2 1.0 -0.5 1.1 1.3 1.5 0.6 1.1 0.2 1.1 1.0 1.2 1.2 1.2 -1.1 -0.3 1.2 1.0 1.1 1.0
Crohns Disease (2017) 0.3 0.7 4.3 0.8 0.8 0.8 0.7 0.8 0.5 0.5 0.4 -0.4 0.3 1.2 1.0 -2.1 0.7 -0.2 0.9 0.7 1.0 0.7 1.1 -0.6 -0.3 1.2 0.5 1.0 0.8
Irritable Bowel Disease (IBD) 0.2 0.5 8.8 -0.0 0.1 0.2 -0.3 -0.5 -0.5 0.0 -0.6 -0.4 -0.7 -0.1 -0.1 -3.0 -0.3 -1.0 -0.0 -0.1 -0.2 -0.5 -0.1 -0.0 -0.7 -0.2 -0.5 -0.5 0.1
Ulcerative Colitis (UC) 0.6 1.2 6.0 -0.7 -0.5 -0.5 -1.0 -1.3 -1.2 -0.4 -1.1 -0.4 -1.3 -1.1 -0.9 -2.4 -0.9 -1.4 -0.7 -0.7 -1.1 -1.3 -0.9 0.4 -1.1 -1.2 -1.3 -1.4 -0.5
Major Depression (MDD) 0.9 1.2 3.4 -1.3 -1.5 0.1 -1.1 -1.1 -0.9 -1.4 -0.5 -0.4 -0.6 -1.5 -0.8 0.2 -1.1 -1.8 -1.4 -1.4 -1.3 -1.0 -1.1 0.6 -0.0 -1.1 -1.0 -0.6 -1.3
Reaction Time 0.2 0.3 1.0 -0.6 -0.5 -0.9 -0.5 0.0 -0.4 -0.6 -0.7 0.7 -0.3 -0.5 -0.3 -0.0 -0.6 -0.7 -0.4 -0.9 -0.2 -0.3 -0.3 0.6 1.0 0.1 -0.3 -0.4 -0.6
Verbal and Numeric Reasoning (VNR) 2.1 5.1 13.8 -2.4 -2.4 -1.6 -2.4 -2.5 -2.3 -2.2 -2.1 -1.7 -2.5 -2.2 -2.3 -3.7 -2.2 -2.1 -2.0 -1.8 -2.5 -2.4 -2.4 1.9 -0.7 -2.5 -2.3 -2.5 -2.1
Breast Cancer 3.6 8.7 14.3 2.4 2.5 3.4 2.9 3.3 3.2 1.8 2.3 1.9 3.6 3.2 3.1 3.0 2.5 3.8 2.6 1.9 3.3 3.3 3.3 -2.3 2.4 3.5 3.4 3.8 2.3
Ovarian Cancer 0.2 0.3 1.3 0.4 0.2 -0.1 0.5 0.7 0.7 -0.1 -0.3 0.3 0.4 0.5 0.3 0.2 0.6 1.1 -0.1 0.6 0.5 0.7 0.5 -0.0 0.4 0.5 0.6 0.6 0.6
Prostate Cancer 2.8 4.0 6.1 -1.9 -1.9 -2.3 -2.1 -2.3 -2.2 -1.6 -1.4 -1.1 -1.8 -2.5 -1.9 -0.6 -2.0 -2.1 -2.2 -2.0 -2.4 -2.2 -2.4 2.1 -0.0 -2.3 -2.2 -2.3 -1.9
Age at First Birth 3.4 5.0 11.7 2.3 2.3 3.4 2.2 2.2 2.1 2.4 2.4 1.4 2.6 2.5 2.9 1.8 1.8 0.3 2.1 1.2 2.2 2.3 2.3 -2.2 2.0 2.6 2.3 2.9 1.5
Bipolar Disorder (2011) 8.8 8.6 11.9 -3.5 -3.4 -3.1 -3.3 -3.0 -3.2 -3.3 -3.4 -0.7 -3.4 -3.0 -3.0 -1.8 -3.3 -2.0 -3.2 -2.8 -2.9 -3.2 -3.0 2.8 -0.4 -2.7 -3.2 -2.8 -3.0
Body Mass Index (BMI) (2010) 1.2 1.6 17.3 0.9 0.9 1.4 0.8 0.9 0.5 0.8 1.1 -4.2 1.7 1.1 0.8 -2.1 0.8 -0.1 1.4 1.2 0.8 0.6 1.1 -0.7 -0.1 0.8 0.4 0.5 0.7
Coronary Artery Disease (CAD) 0.4 0.5 1.3 -0.9 -0.7 -1.0 -0.5 -0.6 -0.3 -0.6 -1.0 -0.2 0.1 -0.7 -1.0 -0.1 -0.6 -0.6 -0.9 0.1 -0.8 -0.5 -0.9 0.5 -1.1 -1.1 -0.5 -0.8 -0.1
Crohns Disease (2012) 0.5 0.7 4.0 0.6 0.6 0.7 0.5 0.8 0.2 0.3 1.0 -1.3 0.4 1.1 1.0 -2.0 0.2 -1.7 0.6 0.2 0.7 0.5 0.8 -0.1 1.1 1.2 0.2 0.7 0.3
Mean Putamen Volume 0.2 0.2 0.8 -0.6 -0.1 -0.1 -0.6 -0.2 -0.4 -0.6 -0.1 0.3 -0.1 -0.0 -0.0 -0.4 -0.7 -0.6 0.1 -0.8 -0.0 -0.3 0.0 0.9 0.9 0.0 -0.2 0.1 -0.5
Fasting Glucose 0.5 0.5 1.8 0.5 0.4 0.3 0.6 1.0 0.9 0.5 0.6 0.6 1.3 0.8 0.5 0.8 0.6 0.3 0.5 0.4 0.7 1.0 0.7 -0.1 0.8 0.9 0.9 1.3 0.4
HbA1C 0.4 0.4 2.5 0.5 0.4 0.8 0.4 0.5 0.5 0.1 0.9 -0.7 0.8 0.6 0.6 1.6 0.4 0.1 0.3 0.2 0.4 0.4 0.4 -0.9 1.2 0.7 0.6 0.5 -0.0
HDL Cholesterol 2.5 4.2 6.1 2.2 2.2 1.7 2.2 2.5 2.5 2.1 2.4 2.2 1.2 2.3 2.2 1.0 2.2 0.8 1.8 2.1 2.2 2.3 2.3 -2.2 0.0 2.2 2.4 2.0 2.2
LDL Cholesterol 0.8 1.3 3.6 1.4 1.3 1.9 1.2 1.0 1.1 1.3 1.7 0.2 0.9 1.2 1.3 -0.5 1.3 0.6 1.2 1.1 1.1 1.0 1.1 -1.4 -0.3 0.9 1.2 1.0 1.3
Lupus 0.7 1.1 2.1 1.1 1.3 1.1 1.2 0.9 0.9 1.3 0.8 0.6 1.4 0.9 1.5 0.3 0.9 -0.0 1.1 0.5 1.2 1.1 1.0 -1.5 0.4 1.2 1.0 1.2 0.8
Neuroticism (2016) 0.3 0.5 2.4 -0.2 -0.2 -1.0 -0.4 -0.3 -0.3 -0.6 -0.6 1.5 -1.0 -0.5 -0.8 -0.8 -0.1 -0.9 -0.6 0.4 -0.5 -0.6 -0.2 0.3 -1.0 -1.0 -0.5 -0.8 0.4
Primary Biliary Cirrhosis 0.3 0.5 3.2 -0.2 -0.3 -0.9 -0.4 -0.5 -0.5 -0.3 -0.6 -1.7 -0.6 -0.0 -0.4 -1.8 -0.1 -0.9 -0.5 0.3 -0.3 -0.4 -0.3 0.5 -0.6 -0.3 -0.6 -0.7 0.0
Rheumatoid Arthritis 1.1 1.5 2.6 -1.4 -1.4 -0.1 -1.3 -1.3 -1.3 -1.3 -1.3 0.3 -1.6 -1.4 -1.0 -1.6 -1.3 -1.3 -1.2 -1.4 -1.2 -1.2 -1.2 0.9 0.0 -1.0 -1.3 -1.3 -1.3
Schizophrenia (2014) 0.8 1.7 5.1 -1.2 -1.1 -1.0 -1.4 -1.5 -1.5 -0.9 -0.9 -2.3 -0.7 -1.3 -0.9 -1.2 -1.4 -1.1 -1.1 -1.6 -1.4 -1.4 -1.4 1.0 0.6 -0.9 -1.5 -1.2 -1.9
Triglycerides 2.1 3.5 6.4 -2.0 -2.0 -1.4 -2.0 -1.9 -2.1 -2.0 -1.3 -1.7 -1.1 -1.9 -1.5 -0.1 -2.2 -1.6 -2.2 -2.5 -2.0 -2.0 -2.1 2.4 1.8 -1.5 -1.9 -1.3 -2.5
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.9 -1.4 -1.4 -0.7 -1.3 -0.9 -1.2 -1.7 -1.4 -1.6 -0.7 -0.6 -1.1 -0.3 -1.1 -1.0 -1.5 -1.2 -1.0 -1.0 -0.8 1.6 1.2 -0.7 -1.2 -0.8 -1.3
Ulcerative Colitis 0.5 0.7 7.1 -0.4 -0.4 -0.4 -0.7 -0.7 -0.8 -0.3 -0.3 -0.1 -1.0 -0.8 -0.8 -2.7 -0.5 -0.8 -0.6 -0.2 -0.9 -0.8 -0.9 0.3 -0.7 -1.0 -0.8 -1.2 -0.2
Blood Eosinophil Count 1.7 13.3 31.0 3.8 4.0 5.6 3.8 3.3 3.8 3.8 3.7 -2.2 4.6 3.9 3.9 -3.5 3.6 -0.8 3.6 3.2 3.5 3.8 3.6 -4.1 -0.1 3.4 4.0 3.8 3.2
Blood Platelet Count 0.1 1.5 5.2 1.0 1.1 1.9 1.1 1.2 1.1 1.0 2.3 -1.5 1.7 0.7 1.2 -0.5 1.0 -0.9 1.1 0.9 0.9 1.0 0.9 -1.6 -1.1 0.7 1.1 1.0 0.9
Blood Red Count 1.3 12.3 25.2 -3.8 -3.7 -4.0 -3.8 -3.2 -3.3 -4.0 -3.4 -3.8 -1.9 -3.6 -3.9 0.2 -3.6 -5.0 -4.0 -3.5 -3.2 -3.3 -3.5 4.8 1.4 -3.0 -3.2 -3.0 -3.5
Blood White Count 0.4 3.3 7.1 1.7 2.1 1.0 1.7 2.0 2.0 1.5 1.0 -0.6 2.4 2.0 1.0 -1.6 2.1 -0.2 2.0 2.4 2.2 1.8 2.1 -1.4 -2.0 1.3 1.8 1.9 2.7
Heel T-Score 0.3 2.7 20.1 0.6 1.0 2.7 1.1 1.2 0.8 1.6 1.2 4.2 0.8 0.6 0.8 -2.4 0.6 4.5 1.2 0.3 0.7 0.7 0.5 -2.1 0.4 0.3 1.0 0.5 0.7
BMI 1.1 6.4 67.8 -1.2 -0.7 -2.3 -1.4 -1.6 -1.2 -0.8 -0.5 -8.2 1.4 -1.1 -2.5 -5.8 -0.7 -2.7 -1.0 0.4 -1.2 -1.6 -1.1 1.8 -3.4 -2.4 -1.5 -2.2 -0.7
Height 0.1 1.9 10.2 -0.4 -0.8 -2.4 -1.1 -1.3 -0.7 -0.6 -2.5 1.6 -2.1 -0.7 -1.4 0.1 -0.2 -3.2 -1.5 0.4 -1.0 -0.9 -0.9 1.6 -1.3 -1.3 -1.0 -1.1 0.3
Waist Hip Ratio (WHR) 0.1 0.7 6.2 0.0 0.0 -0.3 -0.4 -0.3 -0.9 0.2 -0.8 -1.0 -1.8 -0.5 -0.3 -1.4 -0.3 -2.5 -0.1 -0.1 -0.3 -0.8 -0.0 0.2 -0.4 -0.1 -1.2 -0.6 0.2
Systolic Blood Pressure 0.1 0.5 2.3 -0.2 -0.1 -0.2 -0.6 0.1 -1.0 0.0 1.1 1.5 -1.2 -0.6 -0.1 -0.1 -0.8 -0.1 -0.2 -1.0 -0.3 -0.7 -0.5 0.8 0.7 -0.0 -1.0 -0.7 -0.6
Smoking Status 1.0 2.5 20.6 -0.9 -0.8 -1.1 -1.0 -0.9 -1.4 -0.4 0.4 -4.5 -0.1 -1.1 -0.5 -3.1 -1.2 -3.4 -0.6 -1.1 -1.1 -1.3 -1.1 1.3 0.4 -0.9 -1.5 -1.4 -1.3
Allergy or Eczema 0.8 2.1 6.5 1.1 1.3 2.5 1.4 1.3 1.6 0.8 1.2 -0.9 1.4 1.4 1.4 -0.4 1.2 -2.5 1.0 0.9 1.4 1.5 1.5 -1.8 0.6 1.3 1.8 2.1 1.3
Cardiovascular Disease 0.6 2.0 20.4 -0.2 0.1 0.1 -0.6 -0.1 -1.3 0.2 1.5 -4.5 0.3 -0.3 0.2 -3.0 -1.0 -2.6 -0.1 -1.1 -0.3 -0.9 -0.4 1.3 1.0 0.2 -1.3 -1.0 -1.2
Hypothyroidism (self reported) 0.4 1.0 5.7 1.0 1.1 0.7 1.1 0.6 0.7 1.2 1.0 0.9 1.0 0.7 1.2 2.4 0.6 0.1 1.2 0.1 0.8 0.8 0.7 -0.9 1.4 1.0 0.9 0.6 0.3
Respiratory disease 1.2 2.6 25.2 0.8 0.8 1.9 0.7 1.1 0.8 0.4 0.7 -3.2 1.4 0.9 1.2 -3.5 0.7 -5.0 0.5 0.6 1.0 0.9 1.0 -1.1 0.2 1.2 0.8 1.0 0.9
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.3 0.4 0.8 -0.3 0.2 0.8 0.1 0.3 0.3 -0.8 0.6 0.7 0.6 -0.4 0.2 0.6 0.6 0.2 0.9 0.3 1.2 1.0 0.6 1.0 0.0 0.7 0.2
Lung FEV1/FVC ratio 0.8 3.9 7.8 -2.3 -2.0 -2.5 -2.1 -1.9 -2.1 -2.3 -1.1 -0.8 -1.2 -2.4 -2.1 2.0 -2.2 0.4 -2.0 -2.1 -2.0 -2.1 -2.1 2.8 0.6 -2.0 -2.0 -1.8 -2.4
Lung FVC 0.5 2.6 26.9 0.1 -0.3 -0.0 0.1 0.2 -0.1 0.1 1.5 -5.2 0.4 -0.4 -0.4 -3.9 0.1 -4.4 -0.2 0.5 -0.7 -0.3 -0.8 -0.5 -1.1 -0.8 -0.2 -1.0 0.0
Neuroticism 0.5 1.1 20.6 -0.4 -0.3 -0.8 -0.4 -0.1 -0.2 -0.5 -0.9 4.5 -1.7 -0.6 -0.6 -0.6 -0.2 0.7 -0.4 0.0 -0.5 -0.4 -0.4 0.4 -0.9 -0.7 -0.3 -0.5 0.2
Chronotype (morning person) 0.3 0.7 4.6 -0.1 0.1 1.2 -0.1 0.2 -0.4 -0.1 1.1 -2.0 1.0 0.3 0.7 -0.4 -0.5 -1.1 0.1 -0.9 0.2 -0.0 0.1 -0.1 2.1 0.8 -0.2 0.2 -1.0
Hair Pigment 0.1 2.5 4.7 1.9 1.9 1.4 1.9 1.6 1.5 1.9 1.6 -0.0 1.6 1.5 2.0 0.4 1.7 0.2 1.9 1.5 1.6 1.6 1.7 -2.2 -0.4 1.6 1.4 1.6 1.7
Tanning 0.1 1.4 4.0 1.0 1.0 0.8 1.0 1.2 1.2 1.2 0.6 1.5 1.4 1.0 1.1 2.0 1.0 1.5 0.8 0.5 1.3 1.3 1.3 -1.1 1.1 1.4 1.3 1.4 0.8
Hand grip strength (left) 0.2 0.5 5.4 0.3 0.1 0.7 0.0 -0.2 -0.4 0.6 0.3 -1.3 -0.6 -0.0 0.1 -2.3 0.1 1.0 0.1 0.5 -0.3 -0.4 -0.2 -0.8 -1.3 -0.2 -0.7 -0.7 -0.1
Number of treatments/medications taken 0.8 1.5 5.7 -0.8 -0.7 -0.7 -1.1 -1.3 -1.4 -0.4 -0.1 -2.0 -1.3 -1.1 -0.9 -1.9 -1.2 -2.4 -0.2 -1.0 -1.3 -1.4 -1.2 1.1 -0.3 -1.3 -1.5 -1.2 -1.1
Average weekly spirits intake 0.8 0.9 2.1 -1.3 -1.3 -1.1 -1.0 -0.8 -0.5 -1.4 -1.3 0.8 -1.1 -1.1 -1.3 -0.6 -0.8 -0.1 -1.2 -0.7 -0.9 -0.8 -1.1 0.7 -0.5 -1.2 -0.5 -0.6 -0.7
Sensitivity / hurt feelings 0.4 0.7 10.9 0.5 0.7 0.3 0.5 0.4 0.1 0.7 0.1 3.3 -0.3 0.5 0.9 0.6 0.1 0.8 0.5 -0.2 0.5 0.4 0.4 -0.3 1.0 0.8 0.2 0.5 0.1
Frequency of depressed mood in last 2 weeks 0.3 0.5 2.2 -0.5 -0.3 -1.0 -0.6 -0.3 -0.6 -0.7 -0.6 1.0 -1.5 -0.5 -0.6 -1.5 -0.4 -0.4 -0.2 -0.0 -0.2 -0.6 -0.2 0.7 -1.1 -0.5 -0.8 -0.5 0.1
Hearing difficulty/problems: Yes 4.3 6.6 17.1 -2.6 -2.5 -2.6 -2.6 -2.5 -2.4 -2.6 -2.6 -4.1 -2.0 -2.4 -2.3 -3.8 -2.4 -3.1 -2.5 -2.1 -2.4 -2.5 -2.4 2.6 -0.6 -2.3 -2.4 -2.3 -2.4
Relative age of first facial hair 0.1 0.2 0.9 0.1 0.2 0.7 0.3 0.7 0.6 0.0 0.3 0.5 0.1 0.3 -0.0 -0.6 0.5 -0.1 0.2 0.6 0.4 0.4 0.2 -0.8 -1.0 -0.0 0.5 0.3 0.5
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 4.6 -0.7 -0.4 -0.6 -0.7 -1.3 -1.1 -0.3 -0.7 -2.1 -0.7 -0.8 -0.7 -1.9 -0.9 -1.9 -0.3 -0.7 -1.1 -1.2 -0.9 1.2 -0.4 -1.2 -1.2 -0.8 -1.0
Ever used hormone-replacement therapy (HRT) 2.3 2.9 5.9 -1.7 -1.8 -1.8 -1.8 -1.9 -1.5 -1.8 -2.4 0.1 -2.2 -2.0 -2.0 -0.4 -1.4 -1.4 -1.8 -0.9 -1.8 -1.7 -1.8 1.3 -1.8 -2.1 -1.7 -2.0 -1.0
Ever had hysterectomy (womb removed) 5.1 5.8 9.4 -2.5 -2.4 -2.6 -2.5 -2.6 -2.7 -2.2 -1.7 -2.1 -2.2 -2.6 -2.1 -0.8 -2.6 -3.1 -2.4 -2.6 -2.7 -2.6 -2.8 2.5 0.3 -2.3 -2.7 -2.5 -2.6
Systolic blood pressure, automated reading 0.1 0.3 1.1 -0.2 0.0 -0.4 -0.6 -0.4 -0.9 0.2 0.6 1.1 -0.9 -0.6 -0.3 0.1 -0.6 -0.4 -0.0 -0.6 -0.5 -0.8 -0.6 0.2 0.2 -0.5 -1.0 -0.8 -0.4
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 2.1 1.0 1.4 0.7 0.7 0.8 0.2 1.2 1.5 -0.2 0.4 0.8 1.0 -0.7 0.5 0.3 1.2 0.4 1.0 0.5 1.0 -0.6 0.2 1.0 0.2 0.7 0.6
Angina 0.3 0.4 1.4 0.6 0.8 0.1 0.5 0.8 0.7 0.8 0.7 -0.8 1.2 0.5 0.6 -0.4 0.5 0.2 0.6 0.1 0.8 0.7 0.6 0.0 0.2 0.7 0.8 0.8 0.4
Medication for hormone replacement therapy 2.0 2.3 3.6 -1.7 -1.7 -1.4 -1.7 -1.7 -1.6 -1.8 -1.8 0.4 -1.7 -1.9 -1.4 -0.8 -1.8 -0.5 -1.5 -1.9 -1.5 -1.6 -1.5 1.6 0.0 -1.3 -1.6 -1.5 -1.6
Vitamin and mineral supplements 0.5 0.7 1.4 0.8 0.7 0.8 0.9 0.9 0.9 0.7 0.4 -1.1 1.1 0.8 0.6 -0.3 1.0 0.0 0.6 1.2 0.7 0.8 0.7 -1.1 -0.8 0.5 0.9 0.8 0.9
Supplements: Zinc 2.4 2.6 5.0 -1.6 -1.3 -1.0 -1.7 -2.1 -2.1 -1.2 -1.9 0.6 -2.2 -1.7 -0.8 -0.6 -2.0 -0.1 -1.5 -2.2 -1.6 -1.9 -1.6 1.5 1.4 -1.2 -2.0 -1.6 -2.0
Medication: Co-codamol 0.7 0.8 1.9 1.0 1.2 0.9 0.8 0.5 0.6 1.1 -0.1 1.4 -0.0 0.9 0.9 0.2 0.8 0.4 1.1 1.0 1.0 0.6 1.1 -0.6 -1.2 0.8 0.5 1.0 1.3
Medication: Metformin 0.2 0.3 1.4 -0.3 -0.1 -0.7 -0.5 -0.4 -0.6 -0.3 -0.6 -0.8 -0.7 -0.3 -0.7 -1.2 -0.3 -0.2 -0.3 0.2 -0.3 -0.6 0.1 1.2 -0.6 -0.6 -0.7 -0.1 -0.1
Diabetes (father) 1.0 1.3 5.4 -1.2 -0.9 -1.2 -1.1 -0.8 -1.1 -1.2 -0.9 -1.0 -0.8 -1.0 -1.6 -1.3 -1.1 -2.3 -1.0 -0.6 -0.9 -1.2 -0.8 1.4 -0.8 -1.2 -1.2 -1.0 -0.7
Diabetes (mother) 0.4 0.5 1.9 -0.7 -0.6 -1.3 -0.6 -0.3 -0.3 -1.0 -1.4 1.0 -0.9 -0.6 -1.0 -0.3 -0.3 -0.1 -0.5 0.0 -0.2 -0.4 -0.1 0.8 -1.0 -0.4 -0.5 -0.4 0.1
Severe depression (siblings) 0.9 1.1 6.8 0.7 0.9 2.1 0.8 0.7 0.4 0.7 1.4 0.4 0.7 1.0 1.4 -0.0 0.3 1.1 0.9 -0.2 0.7 0.6 1.1 -0.6 2.6 1.4 0.5 0.9 -0.1
Pack years adult smoking proportion 0.1 0.2 0.9 -0.4 -0.4 -0.4 -0.5 -0.4 -0.5 -0.5 -0.3 0.0 -0.4 -0.3 -0.3 1.0 -0.5 0.1 -0.4 -0.5 -0.3 -0.5 -0.1 0.4 0.5 -0.2 -0.5 -0.4 -0.3
Impedance of leg (right) 0.7 3.2 22.0 1.7 1.2 0.3 1.6 1.3 1.8 1.4 -0.9 4.7 -1.0 1.0 0.9 3.4 2.0 0.4 1.0 2.0 1.3 1.5 1.1 -1.9 -1.1 0.9 1.5 1.6 2.5
Leg fat-free mass (left) 0.6 3.0 21.3 -1.2 -1.0 -1.5 -1.4 -1.6 -1.3 -1.1 -0.7 -4.6 0.3 -0.9 -1.8 -3.8 -1.0 -2.3 -1.4 -0.3 -1.3 -1.4 -1.0 1.9 -1.1 -1.7 -1.4 -1.7 -1.1
Trunk fat percentage 1.1 4.6 26.5 -0.7 -0.9 -3.4 -0.8 -1.5 0.1 -0.9 -2.7 -5.2 0.7 -0.9 -3.1 -1.7 0.5 -4.3 -1.2 1.8 -1.0 -0.7 -1.0 1.4 -4.2 -2.6 -0.3 -1.3 0.8
Hand grip strength (right) 0.2 0.5 3.0 0.7 0.3 1.3 0.4 0.3 -0.3 1.0 1.1 -1.0 -0.4 0.0 0.5 -1.7 0.3 1.3 0.1 0.5 -0.1 -0.1 0.0 -0.8 -0.9 0.1 -0.5 -0.3 0.1
Townsend deprivation index at recruitment 0.7 1.0 12.0 -0.1 0.1 -0.9 -0.0 -0.1 0.2 0.1 0.4 -3.5 0.9 -0.3 -0.6 -2.7 0.3 -1.1 0.1 0.5 -0.2 -0.1 -0.3 0.3 -1.5 -0.9 0.1 -0.7 0.2
Current tobacco smoking 0.7 1.2 3.1 1.2 1.3 0.7 1.1 1.2 0.8 1.3 1.8 -0.5 1.6 1.2 1.6 -0.9 0.8 -0.2 1.3 0.5 1.2 1.0 1.2 -1.0 0.7 1.5 0.9 1.1 0.7
Average weekly fortified wine intake 0.4 0.4 3.2 0.3 0.0 -0.2 0.2 -0.0 0.4 0.2 -0.6 1.8 -0.5 0.1 -0.2 1.8 0.4 1.7 -0.1 0.6 0.0 0.2 -0.1 -0.5 -0.5 -0.2 0.3 0.0 0.5
Maternal smoking around birth 1.8 2.5 11.6 -1.6 -1.9 -1.5 -1.5 -1.2 -1.4 -1.8 -1.4 -2.5 -0.7 -1.4 -1.4 -0.6 -1.5 -3.4 -2.0 -1.3 -1.4 -1.3 -1.5 1.4 0.5 -1.1 -1.4 -1.7 -1.4
Fed-up feelings 2.1 3.7 7.0 2.0 2.1 1.1 2.0 2.2 2.1 1.7 1.6 2.6 1.0 1.9 1.5 0.2 2.3 1.3 2.1 2.6 2.0 1.9 2.4 -1.9 -1.5 1.5 2.0 2.2 2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 1.5 -0.0 0.2 -0.6 0.0 -0.1 0.1 -0.1 -0.6 1.2 -0.6 0.1 -0.4 -0.2 0.2 0.2 0.3 0.6 0.2 -0.0 0.2 0.1 -1.2 -0.3 0.0 0.2 0.6
Relative age voice broke 1.8 2.8 4.2 1.7 1.7 2.0 1.7 2.0 1.7 1.6 1.3 2.0 0.9 1.9 1.6 0.5 1.7 1.8 1.6 1.7 1.9 1.7 1.7 -1.8 -0.7 1.6 1.6 1.6 1.9
Taking other prescription medications 2.2 3.3 12.7 -1.7 -1.5 -1.5 -1.8 -2.0 -1.9 -1.4 -1.0 -2.5 -1.5 -2.1 -1.8 -0.8 -1.8 -3.6 -1.4 -1.7 -1.9 -2.0 -1.8 2.0 -0.2 -2.0 -2.0 -1.6 -1.7
Age when periods started (menarche) 0.9 2.3 23.9 0.9 0.8 1.1 0.8 0.8 0.6 1.2 0.8 4.9 -0.8 0.8 1.1 2.6 0.6 3.6 1.0 0.4 0.5 0.6 0.6 -1.0 0.6 0.7 0.6 0.4 0.8
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 2.6 -1.4 -1.1 -1.0 -1.2 -1.2 -1.2 -1.1 -0.8 -0.7 -0.8 -1.1 -0.9 -0.7 -1.4 -1.4 -1.2 -1.6 -1.2 -1.2 -1.4 1.4 0.1 -1.0 -1.1 -0.9 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.0 6.4 2.0 2.0 2.1 1.9 1.7 1.5 2.3 1.7 2.3 0.8 1.7 1.4 -0.4 1.9 2.3 1.8 2.0 1.5 1.5 1.5 -2.5 -0.5 1.1 1.4 1.0 2.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 2.4 0.3 0.1 -0.9 0.1 0.0 0.1 0.3 -0.4 -0.5 -0.4 -0.1 -0.4 -1.1 0.4 -0.2 0.1 0.8 -0.1 -0.1 -0.0 -0.7 -1.5 -0.3 -0.2 -0.2 0.6
Qualifications: CSEs or equivalent 0.7 0.9 2.6 1.3 1.4 0.6 0.8 0.6 0.4 1.3 0.6 0.3 -0.1 0.7 1.0 -0.7 0.9 1.6 1.6 1.0 0.8 0.5 0.9 -1.6 -0.9 0.8 0.2 -0.0 1.1
Serious illness, injury or assault to yourself 0.2 0.3 2.2 0.2 0.4 -0.1 0.0 0.0 0.1 0.3 -0.1 -0.7 -0.4 0.1 -0.1 -1.5 0.3 -1.0 0.3 0.6 0.2 -0.0 0.3 0.1 -1.4 -0.2 -0.0 0.3 0.6
High blood pressure 1.2 3.3 22.3 -1.2 -1.1 -1.0 -1.5 -1.1 -2.0 -1.0 -0.1 -4.7 -0.9 -1.4 -1.1 -2.7 -1.6 -3.1 -1.1 -1.4 -1.4 -1.8 -1.4 1.8 0.2 -1.1 -2.2 -1.9 -1.7
Hayfever, allergic rhinitis or eczema 1.4 3.1 8.5 1.5 1.6 2.9 1.6 1.9 1.8 1.2 1.6 -0.1 1.8 2.0 2.0 0.3 1.4 -1.6 1.2 1.0 2.0 1.9 2.1 -1.8 1.4 2.2 2.0 2.5 1.4
Multivitamins +/- minerals 0.2 0.2 3.0 -0.1 0.1 -0.6 -0.1 0.0 -0.0 0.0 -0.3 1.7 -0.4 0.0 0.0 0.6 -0.1 0.7 0.1 -0.3 0.3 0.1 0.3 0.5 0.5 0.3 0.0 -0.1 -0.1
Stomach or abdominal pain in last month 0.5 0.7 1.4 1.2 1.1 0.8 1.0 0.8 0.8 1.1 1.0 -0.3 0.5 0.9 0.8 0.2 1.1 -0.3 0.7 1.2 0.8 0.8 0.8 -0.9 -0.2 0.7 0.7 0.7 0.9
Supplements: Glucosamine 0.1 0.2 1.2 -0.0 -0.2 0.1 -0.1 -0.3 -0.4 0.1 0.6 0.2 -0.1 -0.2 0.6 1.0 -0.4 -0.1 0.1 -0.7 -0.1 -0.2 -0.4 -0.2 1.1 0.3 -0.3 -0.3 -0.6
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 5.0 -1.7 -1.7 -1.2 -1.5 -1.3 -1.1 -1.6 -1.0 -2.2 -0.1 -1.2 -1.3 -2.1 -1.5 -1.7 -1.5 -1.5 -1.3 -1.2 -1.4 1.6 0.0 -1.1 -1.0 -1.0 -1.8
Medication: Atenolol 2.1 2.6 4.5 1.7 1.8 0.8 1.7 1.6 1.8 1.9 1.0 -0.2 1.6 1.8 1.3 -1.1 1.9 1.6 1.7 2.1 1.7 1.7 1.6 -1.5 -1.8 1.3 1.7 1.4 2.0
Medication: Levothyroxine sodium 1.0 1.7 4.3 1.6 1.6 1.3 1.6 0.8 1.1 1.9 1.2 1.3 1.0 1.3 1.6 2.1 1.1 0.7 1.6 0.7 1.0 1.2 1.0 -1.1 1.3 1.2 1.2 1.0 0.8
Sitting height 0.4 3.1 6.2 -1.4 -1.7 -2.2 -2.0 -2.1 -1.9 -1.3 -1.8 -0.7 -2.0 -1.6 -1.7 -2.5 -1.6 -1.6 -2.1 -1.3 -2.0 -1.9 -1.9 1.7 0.5 -1.6 -2.0 -1.9 -1.6
Chronic bronchitis/emphysema (father) 2.9 3.5 16.1 -1.6 -1.4 -1.4 -1.7 -2.2 -1.8 -1.7 -1.9 -4.0 -1.2 -1.6 -1.4 -1.6 -1.7 -3.8 -1.4 -1.5 -1.4 -1.8 -1.4 1.7 0.5 -1.4 -1.9 -1.4 -1.5
High blood pressure (mother) 0.3 0.5 1.6 -0.1 0.1 -0.5 -0.4 -0.5 -0.9 0.4 0.9 -0.9 -0.9 -0.6 -0.3 -1.3 -0.5 0.2 0.3 -0.3 -0.5 -0.9 -0.6 0.3 -0.9 -0.6 -1.1 -1.1 -0.4
Body mass index (BMI) 1.1 4.9 39.2 -1.1 -0.9 -2.6 -1.3 -1.8 -1.0 -0.8 -1.1 -6.3 0.6 -1.2 -2.7 -4.3 -0.5 -2.6 -1.0 0.6 -1.5 -1.5 -1.3 1.6 -3.5 -2.6 -1.3 -2.2 -0.5
Impedance of leg (left) 0.5 2.5 20.6 1.4 0.8 0.2 1.3 1.0 1.5 1.1 -1.1 4.5 -1.0 0.6 0.7 3.4 1.7 0.1 0.7 1.6 0.9 1.3 0.8 -1.7 -0.8 0.7 1.3 1.5 2.1
Leg predicted mass (left) 0.5 2.9 21.0 -1.1 -1.0 -1.5 -1.3 -1.5 -1.2 -1.0 -0.7 -4.6 0.3 -0.8 -1.7 -3.7 -0.9 -2.3 -1.4 -0.2 -1.2 -1.3 -1.0 1.8 -1.1 -1.6 -1.3 -1.7 -1.0
Trunk fat mass 1.4 6.1 33.5 -1.3 -1.4 -3.7 -1.5 -2.1 -0.7 -1.3 -2.7 -5.8 0.1 -1.4 -3.5 -3.0 -0.2 -4.6 -1.8 1.2 -1.6 -1.4 -1.5 2.0 -4.1 -3.0 -1.1 -2.1 0.0
Waist circumference 1.9 7.0 36.6 -1.7 -1.6 -3.2 -1.8 -2.3 -1.3 -1.5 -2.6 -6.0 -0.3 -1.9 -3.5 -4.5 -0.9 -4.5 -1.9 0.2 -2.0 -1.9 -1.8 2.4 -3.5 -3.3 -1.6 -2.4 -0.7
Number of incorrect matches in round 3.1 5.1 7.0 -2.5 -2.6 -2.5 -2.6 -2.4 -2.3 -2.5 -2.2 -1.7 -1.7 -2.4 -2.3 -0.4 -2.5 -2.1 -2.6 -2.5 -2.3 -2.2 -2.5 2.4 1.2 -1.8 -2.2 -2.2 -2.6
Past tobacco smoking 2.7 5.0 32.5 1.6 1.4 1.3 1.8 1.8 2.3 1.2 0.4 5.7 1.0 1.8 1.4 4.0 1.9 3.9 1.5 1.6 1.8 2.2 1.8 -1.9 0.0 1.7 2.4 2.3 2.0
Alcohol usually taken with meals 0.4 0.7 3.7 -0.8 -0.8 -0.1 -0.7 -0.7 -0.8 -1.1 -0.4 0.5 -0.5 -0.6 -0.4 1.2 -1.0 0.3 -0.7 -1.3 -0.7 -0.6 -0.7 1.2 1.9 -0.2 -0.6 -0.4 -1.1
Nervous feelings 0.5 0.9 11.0 0.7 0.5 0.5 0.4 0.8 -0.0 0.6 1.0 3.3 -1.3 0.1 0.4 0.6 0.4 2.0 0.6 0.6 0.2 0.1 0.3 -0.9 -0.2 0.2 -0.2 -0.2 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.1 1.3 1.3 0.6 1.3 1.4 1.2 1.2 1.4 0.6 0.9 1.1 0.9 -0.9 1.3 -0.2 1.3 1.3 1.3 1.2 1.2 -1.0 -0.6 1.1 1.1 1.0 1.5
Hearing difficulty/problems with background noise 1.5 2.4 5.3 -1.6 -1.4 -1.2 -1.7 -1.5 -1.7 -1.5 -1.1 -1.7 -1.3 -1.5 -1.3 -2.3 -1.7 -2.2 -1.4 -1.6 -1.6 -1.7 -1.4 1.8 0.1 -1.4 -1.6 -1.5 -1.7
Hair/balding pattern: Pattern 2 0.3 0.4 6.6 0.2 0.2 0.4 -0.0 -0.2 -0.1 0.6 -0.3 2.6 -0.9 -0.1 -0.0 0.4 0.1 1.3 0.1 0.1 -0.3 -0.2 -0.1 -0.1 -0.1 -0.4 -0.2 -0.2 0.2
Had menopause 1.1 1.4 3.3 -1.5 -1.4 -0.9 -1.3 -1.4 -1.1 -1.3 -1.0 -0.5 -0.1 -1.2 -0.8 0.3 -1.5 -1.4 -1.4 -1.7 -1.3 -1.0 -1.3 1.3 1.0 -0.9 -0.9 -0.9 -1.8
Had other major operations 0.8 0.9 2.1 1.1 1.3 1.3 1.1 0.7 0.8 1.5 1.2 -0.0 1.3 1.0 1.2 0.7 0.8 0.7 1.1 0.6 0.9 0.9 1.0 -0.7 0.1 0.9 0.9 0.9 0.6
Forced vital capacity (FVC) 0.4 1.4 4.1 1.3 0.8 1.3 1.2 1.3 1.2 1.2 1.5 -1.3 1.2 1.2 1.1 -2.0 1.2 -1.7 0.6 1.2 0.8 1.2 0.7 -1.2 0.2 1.0 1.2 0.7 1.0
Heel bone mineral density (BMD) T-score, automated (right) 2.2 5.0 9.6 2.3 2.4 3.1 2.4 2.3 2.1 2.8 2.3 2.7 1.9 2.3 2.3 -0.0 2.2 2.7 2.2 1.9 2.2 2.1 2.1 -2.8 0.6 1.9 2.2 2.0 2.1
Ever unenthusiastic/disinterested for a whole week 6.1 7.4 13.8 3.4 3.1 2.0 3.1 3.1 2.9 3.2 2.7 0.6 2.4 2.9 2.4 0.1 3.4 1.5 3.1 3.7 2.8 2.8 2.8 -3.1 -1.7 2.2 2.6 2.1 3.5
Qualifications: None of the above 0.1 0.2 1.5 0.2 0.2 -0.7 0.0 0.2 0.2 0.3 0.1 0.8 -0.4 -0.1 -0.4 1.2 0.4 -0.3 0.1 0.6 0.1 0.1 0.3 -0.2 -0.8 -0.2 0.1 0.1 0.7
Financial difficulties in last 2 years 0.6 0.8 2.6 1.0 1.2 -0.3 0.7 0.4 0.6 0.9 -0.1 -0.4 0.4 1.1 0.7 -1.6 1.0 0.1 1.2 1.4 1.0 0.7 1.0 -0.6 -1.3 0.7 0.4 0.1 1.4
Mouth/teeth dental problems 1.2 1.9 4.6 1.2 1.1 0.8 1.4 1.5 1.8 1.1 0.9 0.8 1.6 1.3 0.8 1.0 1.6 2.1 1.5 1.6 1.4 1.6 1.2 -1.7 -0.9 1.0 1.8 1.1 1.6
Heart attack 0.8 1.0 6.6 0.8 0.8 -0.8 0.7 0.4 0.9 0.8 -0.7 -1.6 0.4 0.8 -0.1 -1.1 1.2 -0.7 0.9 1.7 0.7 0.6 0.6 -0.8 -2.6 0.1 0.7 0.3 1.5
Allergy 2.0 4.6 9.4 -2.0 -2.0 -3.1 -2.0 -2.5 -2.2 -1.7 -2.1 1.3 -2.2 -2.3 -2.2 1.3 -2.1 2.9 -1.5 -1.8 -2.2 -2.3 -2.4 2.3 -0.6 -2.3 -2.3 -2.5 -2.1
Pain all over the body in last month 0.3 0.3 1.4 -0.3 -0.4 -1.0 -0.5 -0.5 -0.4 -0.3 -0.8 0.6 -1.2 -0.5 -0.7 -0.4 -0.2 0.3 -0.4 -0.0 -0.4 -0.5 -0.5 0.4 -0.9 -0.6 -0.5 -0.3 -0.0
Diabetes (self-reported) 0.3 0.4 2.1 -0.4 -0.1 -1.4 -0.7 -0.4 -0.8 -0.4 -0.3 -1.0 -0.7 -0.3 -0.7 -0.9 -0.5 -0.1 -0.2 -0.0 -0.3 -0.7 -0.1 1.1 -0.9 -0.5 -1.0 -0.6 -0.2
Hayfever/allergic rhinitis (self-reported) 2.1 2.7 4.7 1.7 1.7 2.1 1.7 1.8 1.8 1.5 1.2 2.0 0.8 1.9 1.8 1.2 1.8 0.1 1.3 1.6 1.8 1.9 1.7 -2.2 0.1 1.9 1.8 1.8 1.8
Medication: Ramipril 0.3 0.4 5.3 0.2 0.4 -0.1 0.0 -0.0 -0.3 0.5 0.5 -2.3 0.0 0.0 -0.0 -1.7 -0.1 -0.5 0.6 -0.1 0.0 -0.2 0.0 0.2 -0.4 -0.0 -0.3 -0.6 -0.1
Medication: Simvastatin 0.9 1.3 5.0 -1.2 -0.9 -1.0 -1.0 -0.9 -0.9 -0.9 -0.4 -2.2 -0.1 -1.0 -1.4 -1.1 -1.1 -1.8 -0.7 -0.9 -1.1 -1.1 -1.1 1.7 -0.2 -1.4 -0.9 -1.0 -1.0
Fluid intelligence score 3.6 7.5 9.8 -3.0 -3.0 -1.5 -2.9 -3.0 -3.0 -2.8 -2.4 -1.7 -2.7 -3.0 -2.6 -2.7 -3.0 -2.4 -2.8 -2.8 -3.1 -3.0 -3.0 2.7 0.1 -2.8 -2.9 -3.1 -3.0
Illnesses of siblings 0.3 0.4 6.3 -0.2 -0.3 0.2 -0.1 -0.2 0.1 -0.3 -1.3 2.5 -0.8 -0.2 -0.3 0.6 0.0 -0.1 -0.4 0.1 -0.1 -0.0 -0.0 -0.5 -0.2 -0.2 0.1 0.1 0.5
Neuroticism score 0.4 0.9 15.6 0.6 0.7 0.3 0.5 0.8 0.4 0.6 0.6 3.9 -0.7 0.4 0.4 -0.1 0.5 1.2 0.7 0.6 0.5 0.4 0.6 -0.5 -0.3 0.3 0.4 0.4 0.8
Weight 1.2 6.1 32.7 -1.5 -1.4 -3.1 -1.8 -2.3 -1.4 -1.3 -1.9 -5.7 -0.2 -1.6 -3.2 -4.5 -0.9 -3.7 -1.9 0.4 -2.0 -1.9 -1.8 2.1 -3.2 -3.1 -1.7 -2.5 -0.8
Impedance of arm (right) 1.0 4.7 35.0 1.6 1.1 0.8 2.0 1.8 2.7 1.0 -0.6 4.0 0.9 1.6 1.0 5.9 2.3 -0.5 1.1 2.1 1.8 2.4 1.5 -1.4 0.1 1.5 2.7 2.4 2.6
Arm fat percentage (right) 1.5 6.0 39.4 -1.3 -1.4 -3.5 -1.4 -2.0 -0.7 -1.3 -2.3 -6.3 0.3 -1.5 -3.5 -2.7 -0.3 -4.2 -1.6 1.1 -1.7 -1.4 -1.6 1.9 -4.2 -3.2 -1.1 -2.2 -0.1
Trunk fat-free mass 0.8 4.6 21.3 -1.8 -1.6 -1.3 -2.1 -2.2 -2.3 -1.5 -0.7 -3.7 -1.0 -1.7 -1.7 -4.6 -2.0 -1.9 -2.1 -1.6 -2.1 -2.2 -1.8 2.2 -0.1 -2.0 -2.3 -2.3 -2.3
Hip circumference 1.8 7.9 35.0 -2.3 -2.2 -3.7 -2.2 -2.7 -1.4 -2.2 -2.8 -5.9 -0.2 -2.2 -3.8 -4.0 -1.2 -4.1 -2.5 -0.1 -2.4 -2.1 -2.4 2.9 -3.5 -3.7 -1.6 -2.5 -1.3
Time employed in main current job 0.4 0.4 1.8 0.8 0.5 0.4 0.7 0.2 0.6 0.7 -0.3 0.9 -0.3 0.4 0.1 0.4 1.0 0.2 0.6 1.4 0.3 0.5 0.3 -0.8 -1.2 0.1 0.4 0.4 1.2
Alcohol intake versus 10 years previously 0.2 0.3 0.7 0.7 0.8 0.4 0.5 0.4 0.3 0.8 0.7 -0.3 0.5 0.5 0.7 0.0 0.5 0.4 0.8 0.4 0.6 0.4 0.8 -0.5 -0.1 0.6 0.2 0.5 0.5
Father’s age at death 2.6 3.5 8.2 -2.1 -1.9 -2.1 -2.0 -2.6 -1.8 -2.0 -2.9 -1.2 -1.8 -2.2 -2.0 -0.7 -1.9 -1.3 -1.9 -1.8 -1.8 -1.9 -2.0 1.6 -0.8 -2.0 -1.8 -1.5 -1.7
Worrier / anxious feelings 0.3 0.5 7.1 0.4 0.5 0.5 0.3 0.6 0.3 0.4 0.7 2.7 -0.1 0.2 0.6 0.2 0.2 0.7 0.4 -0.1 0.4 0.4 0.4 -0.3 1.0 0.5 0.4 0.4 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.7 0.9 1.0 -0.1 0.9 0.4 0.9 0.9 -0.4 1.3 -0.1 0.6 0.3 -0.9 1.0 0.6 0.9 1.2 0.8 0.7 0.7 -0.5 -1.6 0.3 0.8 0.5 1.4
Falls in the last year 0.9 1.2 2.8 -1.2 -1.2 -1.0 -1.0 -1.1 -0.7 -1.2 -1.3 -0.0 -1.2 -1.1 -1.5 -0.7 -0.8 -0.9 -1.2 -0.5 -1.1 -1.0 -1.0 1.6 -1.2 -1.7 -0.6 -0.9 -0.6
Hair/balding pattern: Pattern 3 0.2 0.2 2.5 0.3 0.4 0.3 0.4 0.0 0.1 0.3 0.6 -1.6 0.6 0.1 0.6 -0.7 0.1 0.7 0.4 -0.1 0.3 0.2 0.4 -0.5 -0.1 0.3 0.1 -0.1 -0.1
Number of live births 0.2 0.2 1.0 -0.2 -0.4 -0.3 -0.1 -0.7 -0.3 -0.1 -1.0 0.7 -0.9 -0.5 -0.5 -0.0 -0.1 -0.5 -0.3 -0.0 -0.7 -0.4 -0.5 0.0 -0.7 -0.7 -0.4 -0.7 -0.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.9 0.6 0.3 0.5 0.6 0.7 0.5 0.6 0.9 -1.4 0.4 0.5 0.4 -1.4 0.6 -0.9 0.0 0.7 0.2 0.5 0.1 -0.4 0.0 0.3 0.5 0.1 0.4
Pulse rate 1.9 3.3 5.8 -1.7 -1.7 -1.0 -1.8 -1.9 -2.2 -1.4 -1.5 -1.1 -2.0 -1.7 -1.6 -1.5 -2.0 -2.4 -1.9 -1.8 -2.2 -2.1 -1.9 1.7 1.3 -1.7 -2.3 -1.7 -2.2
Happiness 0.3 0.3 2.7 0.4 0.7 -0.5 0.4 0.2 0.3 0.3 -0.2 -0.1 -0.2 0.4 0.2 0.1 0.6 -0.3 0.8 0.9 0.6 0.3 0.7 -0.3 -1.6 0.2 0.2 0.2 1.0
Noisy workplace 0.1 0.2 1.1 0.4 0.6 -0.3 0.2 0.2 0.1 0.5 0.2 0.0 -0.0 0.3 0.1 -0.4 0.3 -0.3 0.4 0.5 0.3 0.1 0.4 -0.5 -1.0 0.1 0.0 0.2 0.6
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.5 0.4 0.4 1.2 0.6 0.4 0.7 0.4 -0.3 1.0 0.5 0.2 0.4 0.0 0.5 0.9 0.4 0.4 0.4 0.6 0.3 -0.8 -0.2 0.2 0.8 0.2 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 1.3 0.3 0.5 0.8 0.4 0.5 0.4 0.3 0.8 -0.2 1.0 0.4 0.8 -0.3 0.1 -0.5 0.4 -0.2 0.3 0.4 0.4 -0.1 1.1 0.5 0.5 0.4 -0.1
Mouth/teeth dental problems: Dentures 2.6 4.4 7.7 -1.8 -1.9 -2.5 -2.1 -2.6 -2.5 -1.5 -1.5 -0.9 -2.5 -2.3 -1.9 0.1 -2.1 -2.8 -2.0 -1.9 -2.5 -2.5 -2.4 1.8 0.2 -2.3 -2.6 -2.5 -2.1
Asthma 1.5 3.0 12.9 1.5 1.4 2.1 1.4 1.9 1.4 1.1 1.4 -2.3 1.7 1.4 1.7 -2.7 1.4 -3.6 1.2 1.3 1.6 1.5 1.6 -1.9 0.0 1.7 1.4 1.4 1.5
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.9 1.1 1.3 1.6 1.3 1.1 1.1 1.5 1.1 1.7 0.5 1.4 1.3 0.4 1.0 1.1 1.6 0.8 1.2 1.1 1.1 -1.1 0.1 1.2 1.1 1.1 1.0
Medication: Cholesterol lowering 0.3 0.4 3.8 -0.4 0.1 0.1 -0.4 -0.1 -0.7 -0.0 0.7 -1.9 0.2 0.1 -0.2 -1.5 -0.6 -0.6 0.1 -0.6 -0.1 -0.5 0.0 1.1 0.3 -0.0 -0.6 -0.0 -0.5
Depression (self-reported) 0.2 0.3 1.0 0.4 0.1 0.9 0.6 0.7 0.7 0.4 1.0 -0.4 1.0 0.5 0.3 -0.2 0.6 -0.6 0.2 0.6 0.1 0.5 0.1 -0.3 0.5 -0.0 0.7 0.7 0.1
Medication: Lansoprazole 0.4 0.5 2.3 -0.4 -0.6 -0.6 -0.3 -0.4 -0.1 -0.4 -0.8 0.5 -0.7 -0.8 -1.3 -0.2 0.0 -0.0 -0.4 0.4 -0.9 -0.5 -0.8 0.3 -1.5 -1.4 -0.3 -0.4 0.2
Prospective memory result 2.1 2.6 5.9 1.7 1.7 1.5 1.9 1.6 1.7 1.7 1.4 0.6 1.8 1.7 1.7 2.4 1.7 1.1 1.4 1.5 1.7 1.7 1.7 -1.4 -0.0 1.7 1.7 1.9 1.4
Lung cancer (father) 1.4 1.6 2.6 -1.5 -1.4 -1.5 -1.5 -1.1 -1.3 -1.3 -0.4 -1.3 -0.9 -1.4 -1.5 -0.5 -1.4 -1.3 -1.4 -1.3 -1.3 -1.3 -1.2 1.6 -0.2 -1.4 -1.3 -1.1 -1.3
Illnesses of mother 0.3 0.3 1.8 -0.7 -0.8 0.1 -0.1 -0.1 0.6 -1.1 -1.3 0.0 0.2 -0.1 -0.9 0.4 0.1 0.0 -0.7 0.4 -0.2 0.2 -0.3 0.1 -0.8 -0.8 0.7 0.1 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 1.5 0.3 -0.0 0.2 0.1 0.3 0.0 0.4 0.6 -0.7 0.1 0.1 0.2 -1.2 0.1 -1.0 -0.2 0.1 -0.1 0.0 -0.2 -0.1 0.4 0.1 -0.0 -0.3 -0.1
Pulse wave Arterial Stiffness index 1.9 2.2 7.6 -1.4 -1.1 0.2 -1.3 -1.3 -1.6 -1.1 -0.5 -2.6 -1.1 -1.1 -1.5 -2.8 -1.3 -2.5 -0.9 -0.8 -1.6 -1.7 -1.1 1.1 -0.3 -1.8 -1.7 -1.5 -1.3
Impedance of arm (left) 1.2 5.8 33.6 1.9 1.4 1.1 2.3 2.2 3.1 1.2 -0.6 4.3 1.3 1.9 1.2 5.8 2.7 -0.3 1.3 2.5 2.1 2.8 1.8 -1.8 -0.2 1.7 3.1 2.8 3.0
Arm fat mass (right) 1.7 6.9 39.1 -1.7 -1.6 -3.4 -1.8 -2.5 -1.3 -1.4 -2.2 -6.3 -0.1 -1.7 -3.5 -4.0 -0.9 -4.0 -1.9 0.5 -2.1 -2.0 -1.9 2.2 -3.6 -3.3 -1.7 -2.7 -0.7
Trunk predicted mass 0.8 4.6 21.7 -1.8 -1.6 -1.3 -2.1 -2.2 -2.4 -1.5 -0.7 -3.7 -1.0 -1.7 -1.7 -4.7 -2.0 -2.0 -2.1 -1.7 -2.1 -2.3 -1.8 2.2 -0.0 -2.0 -2.4 -2.3 -2.3
Standing height 0.2 1.5 5.9 -0.9 -1.3 -1.2 -1.2 -1.3 -0.9 -1.1 -1.9 0.6 -1.5 -0.9 -1.3 -0.6 -0.8 -2.4 -2.0 -0.5 -1.3 -1.0 -1.2 1.4 0.4 -1.2 -1.0 -1.1 -0.7
Length of working week for main job 0.1 0.1 0.6 0.2 0.3 -0.4 0.0 -0.4 -0.2 0.2 -0.4 0.2 -0.3 -0.0 0.1 0.2 0.1 0.3 0.2 0.1 0.2 -0.1 0.1 -0.5 -0.8 0.1 -0.3 -0.2 0.2
Exposure to tobacco smoke at home 1.9 2.1 8.8 -1.5 -1.4 -1.1 -1.4 -1.3 -1.3 -1.4 -1.2 -2.0 -1.0 -1.6 -1.6 -3.0 -1.3 -1.1 -1.2 -1.1 -1.3 -1.4 -1.4 1.5 -0.9 -1.5 -1.3 -1.4 -1.3
Breastfed as a baby 0.8 1.1 2.7 -1.1 -1.0 -1.2 -1.1 -1.1 -0.7 -1.1 -1.3 -0.8 -0.8 -0.9 -1.2 -1.6 -0.9 -0.7 -1.2 -0.7 -1.1 -0.9 -1.3 1.0 -0.4 -1.2 -0.6 -0.9 -0.8
Tense / ‘highly strung’ 0.4 0.7 2.0 1.0 1.1 0.6 0.9 1.1 0.6 1.1 0.9 1.4 -0.2 0.7 0.8 0.2 0.9 0.4 1.0 1.0 0.7 0.6 0.8 -1.1 -0.6 0.6 0.5 0.4 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 4.3 1.7 1.2 1.1 1.6 1.3 1.4 1.4 1.6 -1.6 1.6 1.2 0.8 -0.3 1.8 -0.3 1.2 2.1 0.9 1.2 1.1 -1.8 -0.2 0.6 1.1 1.1 1.3
Hair/balding pattern: Pattern 4 0.4 1.0 10.9 -0.8 -0.8 -1.1 -0.8 -0.1 -1.0 -0.7 -0.3 3.3 -1.7 -0.6 -1.0 -0.1 -0.7 1.2 -0.6 -0.5 -0.6 -0.8 -0.6 0.6 -0.0 -0.4 -1.1 -0.9 -0.4
Birth weight of first child 1.5 2.8 7.7 -1.8 -1.9 -0.4 -1.5 -1.4 -1.2 -1.7 -0.9 -2.8 -0.2 -1.4 -1.5 -2.2 -1.6 -2.7 -2.0 -1.8 -1.7 -1.3 -1.8 2.1 1.3 -1.6 -0.9 -1.0 -2.0
Peak expiratory flow (PEF) 0.1 0.3 1.0 0.7 0.5 0.8 0.4 0.4 0.1 0.7 0.2 0.3 -0.1 0.6 0.8 0.0 0.5 1.0 0.3 0.6 0.4 0.3 0.4 -0.8 0.4 0.7 -0.0 0.2 0.3
Pulse wave reflection index 0.7 0.8 3.1 -0.8 -0.8 -0.8 -0.7 -0.7 -0.6 -0.8 -0.9 -1.8 -0.7 -0.6 -1.2 -1.4 -0.4 -1.5 -0.7 0.1 -0.8 -0.8 -0.7 0.7 -1.3 -1.2 -0.7 -0.9 -0.4
Ever highly irritable/argumentative for 2 days 0.3 0.4 2.8 0.9 0.6 -0.4 0.5 0.5 0.2 0.7 0.0 1.7 -1.0 0.4 0.3 0.3 0.8 0.0 0.5 1.1 0.3 0.2 0.3 -0.5 -0.5 0.4 -0.1 -0.0 1.0
Loud music exposure frequency 3.2 3.5 7.4 -1.7 -1.9 -2.2 -1.9 -2.1 -1.8 -1.5 -2.2 0.4 -2.4 -2.3 -2.7 -1.1 -1.5 -1.1 -1.7 -0.9 -2.2 -2.1 -2.1 1.3 -1.9 -2.6 -2.0 -2.0 -1.1
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 4.2 -1.8 -1.7 -0.8 -1.3 -1.3 -0.8 -2.1 -1.3 -0.6 -0.4 -1.6 -1.5 -0.9 -1.3 -0.7 -1.5 -1.3 -1.4 -1.1 -1.6 1.1 -0.6 -1.6 -0.7 -1.3 -1.3
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 4.3 -0.4 -0.2 0.2 -0.4 0.0 -0.5 -0.6 -0.4 -0.5 -0.6 0.2 -0.1 -2.1 -0.3 -1.1 -0.5 -0.0 0.1 -0.3 0.2 1.1 -0.2 0.1 -0.5 0.0 -0.1
Blood clot in the leg (DVT) 0.4 0.5 1.9 -0.3 -0.3 -1.1 -0.5 -0.6 -0.5 -0.1 0.0 0.3 -1.0 -0.9 -0.8 -0.8 -0.3 -0.7 -0.4 -0.0 -0.6 -0.7 -0.5 0.6 -1.4 -1.1 -0.6 -1.3 0.1
Medication: Paracetamol 3.1 5.1 10.9 2.2 2.2 2.7 2.3 2.4 2.4 2.1 1.9 3.3 1.6 2.2 2.2 2.0 2.2 2.4 2.2 1.9 2.3 2.4 2.4 -2.1 0.4 2.2 2.4 2.6 2.2
Headache pain in last month 4.1 7.0 13.6 2.6 2.5 3.1 2.7 3.3 2.9 2.4 2.7 3.7 2.3 2.9 2.9 0.7 2.5 2.3 2.0 2.0 2.9 3.0 3.0 -1.9 0.7 3.0 3.0 3.2 2.5
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 8.8 1.1 0.7 0.6 1.3 0.8 1.6 0.8 -0.2 3.0 0.4 0.7 0.9 1.9 1.4 1.6 0.5 1.3 0.8 1.3 0.7 -2.0 -0.2 0.6 1.5 0.7 1.3
Glaucoma (self-reported) 0.5 0.6 7.6 0.2 0.2 0.4 0.4 0.2 0.5 0.2 -0.5 2.8 -0.3 0.4 -0.1 2.0 0.4 1.2 -0.0 0.6 0.4 0.4 0.3 -0.4 -0.6 0.1 0.5 0.2 0.8
Gout (self-reported) 0.5 0.7 1.7 -0.9 -0.9 -1.0 -0.9 -0.9 -0.7 -0.9 -1.3 -0.3 -0.2 -1.0 -1.0 -0.4 -0.7 -0.9 -1.0 -0.7 -0.8 -0.8 -0.8 1.1 -0.5 -1.0 -0.6 -0.3 -0.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 4.8 0.9 1.0 0.7 1.1 0.5 0.8 1.1 0.7 1.1 1.0 0.7 1.1 2.2 0.6 0.0 1.1 0.1 0.7 0.8 0.6 -0.7 1.4 0.9 0.9 0.5 0.3
Medication: Amlodipine 0.4 0.6 1.6 -0.9 -0.8 -0.8 -0.9 -0.8 -1.0 -0.7 -0.6 -0.0 -1.1 -0.6 -1.0 -0.2 -0.8 -0.0 -0.8 -0.5 -0.8 -1.0 -0.8 1.3 -0.4 -0.9 -1.0 -0.5 -0.8
Medication: Ventolin 100micrograms inhaler 1.2 1.6 3.2 1.2 1.1 1.3 1.2 1.2 1.6 1.1 0.4 -1.1 1.8 1.3 1.4 -1.0 1.3 -1.5 0.8 1.1 1.3 1.5 1.1 -1.3 -0.5 1.3 1.6 1.4 1.3
Birth weight 0.2 0.3 2.0 0.5 0.6 1.4 0.7 0.3 0.5 0.8 0.5 -0.3 0.7 0.4 0.7 -1.2 0.4 0.1 0.4 0.1 0.3 0.4 0.4 -0.2 -0.0 0.3 0.6 0.7 0.1
Chronic bronchitis/emphysema (mother) 0.9 1.0 5.6 0.6 0.5 1.1 0.7 0.8 0.7 0.7 1.9 -2.4 2.1 0.5 0.7 -1.0 0.5 -1.5 0.3 0.2 0.3 0.7 0.4 -0.8 1.3 0.5 0.8 0.8 -0.1
High blood pressure (siblings) 0.4 0.6 5.7 -0.7 -0.5 -0.3 -0.6 -0.3 -0.7 -0.7 0.5 -2.4 0.4 -0.5 -0.3 -1.0 -0.8 -0.5 -0.3 -0.8 -0.5 -0.6 -0.7 1.2 0.5 -0.3 -0.6 -0.7 -1.2
Forced vital capacity (FVC), Best measure 0.2 0.8 4.5 0.9 0.5 1.1 0.8 0.9 0.6 1.0 1.1 -1.0 0.8 0.7 1.0 -2.1 0.6 -1.7 0.4 0.5 0.4 0.7 0.4 -0.8 0.8 0.8 0.6 0.3 0.4
Body fat percentage 1.4 5.7 32.3 -1.0 -1.1 -3.6 -1.1 -1.9 -0.4 -1.0 -2.7 -5.7 0.1 -1.3 -3.4 -2.5 0.1 -4.2 -1.4 1.6 -1.5 -1.2 -1.4 1.5 -4.7 -3.1 -0.9 -1.9 0.5
Leg fat percentage (right) 1.6 5.8 27.9 -1.0 -1.0 -3.7 -1.3 -2.0 -0.9 -0.9 -2.2 -5.3 -0.8 -1.6 -3.4 -3.4 -0.1 -3.5 -1.2 1.4 -1.7 -1.7 -1.6 1.2 -5.0 -3.3 -1.5 -2.4 0.3
Arm fat-free mass (right) 0.8 4.1 25.8 -1.5 -1.2 -1.6 -1.8 -2.0 -1.9 -1.2 -0.9 -4.3 -0.5 -1.3 -1.8 -5.1 -1.6 -1.9 -1.7 -0.9 -1.7 -1.9 -1.4 2.0 -0.9 -1.9 -2.0 -2.1 -1.7
Exposure to tobacco smoke outside home 2.1 2.8 4.8 1.6 1.9 1.6 1.8 1.7 1.9 1.6 1.6 1.5 1.8 1.9 1.4 0.6 1.7 0.6 1.9 1.8 1.9 1.8 2.2 -1.6 -0.6 1.4 1.9 2.1 2.0
Comparative body size at age 10 1.6 4.4 52.9 -1.3 -0.8 -0.0 -1.1 -0.8 -1.0 -1.3 0.1 -7.3 2.6 -0.1 -0.6 -4.5 -1.4 -3.5 -0.9 -1.2 -0.4 -0.8 -0.4 1.8 1.4 -0.1 -0.7 -0.6 -1.8
Number of full brothers 0.8 1.0 2.7 1.0 1.2 1.0 0.7 1.0 -0.0 0.9 1.6 -1.4 0.3 1.1 1.6 -1.4 0.5 0.0 1.2 0.4 1.0 0.5 1.2 -0.7 1.3 1.6 -0.1 0.7 0.2
Worry too long after embarrassment 0.5 0.9 15.6 0.4 0.5 0.4 0.5 0.5 0.5 0.6 0.4 4.0 -0.3 0.3 0.3 0.7 0.4 1.9 0.6 0.3 0.2 0.4 0.3 -0.2 0.4 0.1 0.5 0.4 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 2.7 -0.1 -0.4 -0.0 -0.0 0.5 0.2 -0.4 0.3 -1.2 0.2 -0.2 -0.5 -1.0 0.3 -1.7 -0.3 0.6 -0.2 0.1 -0.1 -0.3 -1.1 -0.4 0.1 0.0 0.2
Wheeze or whistling in the chest in last year 0.9 1.6 6.6 1.2 1.0 1.1 1.2 1.4 1.4 0.9 0.7 -1.4 1.6 1.1 1.1 -0.8 1.3 -2.6 0.5 1.0 1.2 1.4 1.1 -1.1 0.0 1.3 1.4 1.3 1.2
Number of children fathered 0.4 0.4 1.8 -0.1 -0.4 -1.0 -0.4 -0.3 -0.8 -0.3 -0.4 1.2 -1.3 -0.4 -0.5 -0.2 -0.3 1.0 -0.1 -0.0 -0.5 -0.7 -0.4 0.2 -0.8 -0.2 -1.0 -0.8 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 1.5 -0.1 -0.0 0.1 -0.2 -0.1 -0.5 -0.1 -0.3 1.0 -0.5 -0.2 0.3 1.2 -0.3 -0.9 -0.2 -0.4 0.1 -0.2 0.0 0.1 0.3 0.3 -0.5 -0.3 -0.1
Age at first live birth 2.7 4.8 8.4 2.6 2.5 2.2 2.3 2.2 1.8 2.8 2.9 2.3 1.2 2.3 2.6 1.8 2.0 2.4 2.3 1.5 2.3 2.1 2.3 -2.1 1.4 2.6 1.8 1.9 1.8
Pulse wave peak to peak time 1.4 1.6 6.3 1.2 0.9 -0.4 1.1 1.1 1.4 0.9 0.2 2.5 0.9 0.8 1.2 2.5 1.1 2.2 0.6 0.6 1.3 1.5 0.9 -0.9 0.3 1.6 1.4 1.3 1.1
Health satisfaction 0.4 0.5 3.5 -0.1 0.1 -1.5 -0.2 -0.2 -0.2 -0.2 -0.4 -0.9 -0.4 -0.1 -0.8 -1.9 0.1 -0.6 0.1 0.7 -0.0 -0.3 0.2 0.7 -1.8 -0.5 -0.4 -0.3 0.5
Shortness of breath walking on level ground 0.2 0.2 1.8 0.3 0.4 -0.2 0.3 0.4 0.5 0.2 -0.2 0.5 -0.1 0.1 -0.3 -0.4 0.5 -0.0 0.7 0.7 0.4 0.3 0.4 -0.3 -1.3 -0.0 0.4 0.3 0.9
Qualifications: College or University degree 0.1 0.5 2.2 0.1 -0.0 1.5 0.6 0.4 0.8 0.2 0.6 -0.0 1.2 0.3 0.5 1.1 0.2 0.4 0.2 -0.3 0.2 0.7 0.2 0.1 1.5 0.4 1.1 0.9 -0.3
Eye problems/disorders: None of the above 0.6 0.7 4.4 -0.4 -0.6 -0.5 -0.7 -0.5 -0.9 -0.3 -0.1 -2.1 -0.5 -0.5 -0.1 -2.1 -0.7 0.3 -0.2 -0.9 -0.6 -0.7 -0.7 0.7 1.0 -0.1 -0.9 -0.8 -0.9
Mouth/teeth dental problems: Loose teeth 0.2 0.2 2.1 -0.5 -0.4 0.3 -0.3 -0.2 -0.1 -0.7 -0.5 -1.5 0.7 0.1 -0.3 -0.5 -0.3 -0.5 -0.3 -0.1 -0.1 -0.1 -0.1 0.5 0.5 -0.1 -0.0 0.3 -0.3
Emphysema/chronic bronchitis 0.3 0.3 2.3 0.4 0.4 0.5 0.4 0.4 0.5 0.2 -0.5 0.1 0.1 0.4 0.1 0.0 0.6 -0.9 0.2 1.0 0.5 0.4 0.5 -0.5 -1.5 0.3 0.4 0.1 1.0
Medication for pain relief, constipation, heartburn 0.6 1.1 2.1 -1.1 -1.2 -1.3 -1.2 -1.2 -1.1 -1.1 -1.3 -0.5 -0.9 -1.2 -1.1 -0.9 -1.0 -0.4 -1.5 -0.9 -1.1 -1.1 -1.1 0.9 -0.1 -1.1 -1.1 -1.0 -1.0
Neck or shoulder pain in last month 0.7 1.0 1.7 -1.2 -1.2 -0.7 -1.1 -0.8 -1.1 -1.0 -0.8 0.5 -1.1 -1.2 -1.0 -0.3 -1.1 -0.8 -1.3 -1.2 -1.0 -1.1 -1.1 1.1 0.4 -0.9 -1.1 -1.0 -1.1
Medication: Blood pressure 0.3 0.4 4.1 -0.2 0.0 0.1 -0.4 0.1 -0.6 -0.1 0.6 -2.0 0.1 0.2 -0.3 -1.8 -0.4 -1.0 0.1 -0.1 0.0 -0.4 0.1 1.0 -0.4 0.1 -0.7 0.1 -0.3
Angina (self-reported) 0.3 0.4 1.4 0.5 0.7 0.2 0.4 0.7 0.7 0.7 0.7 -0.9 1.2 0.5 0.6 -0.3 0.4 0.2 0.5 0.1 0.7 0.6 0.6 0.1 0.3 0.7 0.8 0.8 0.4
Migraine (self-reported) 0.3 0.4 1.0 0.7 0.7 0.8 0.7 0.4 0.6 0.8 0.2 0.4 0.5 0.7 0.5 0.4 0.7 1.0 0.6 0.9 0.5 0.6 0.6 -0.3 -0.3 0.3 0.6 0.5 0.7
Medication: Ibuprofen 0.5 0.6 3.6 0.7 0.8 1.0 0.8 0.6 0.7 1.0 0.5 1.9 -0.1 0.7 0.6 0.3 0.7 1.4 1.1 0.6 0.6 0.6 0.5 -0.8 -0.4 0.4 0.7 0.7 0.7
Medication: Allopurinol 0.1 0.2 1.1 -0.1 0.0 -0.4 -0.2 -0.3 -0.2 0.1 -0.3 -0.4 0.1 -0.3 -0.3 -1.0 -0.1 -1.0 -0.2 0.0 -0.2 -0.3 -0.1 0.4 -1.0 -0.4 -0.2 -0.0 -0.0
Medication: Omeprazole 1.8 2.2 5.0 -1.3 -1.2 -1.2 -1.4 -1.8 -1.5 -1.2 -1.6 -1.9 -1.8 -1.5 -1.4 -0.3 -1.3 -2.2 -1.3 -0.8 -1.5 -1.6 -1.6 1.1 -1.3 -1.7 -1.6 -1.7 -1.2
Medication: Seretide 50 evohaler 1.3 1.5 4.3 1.1 0.9 2.1 1.2 1.4 1.5 0.7 1.3 -0.1 1.5 1.1 1.1 0.1 1.3 -0.7 1.1 1.0 1.1 1.4 1.1 -1.4 1.1 1.1 1.5 1.6 1.2
Mean time to correctly identify matches 1.1 2.2 3.7 -1.8 -1.8 -1.9 -1.6 -1.1 -1.4 -1.9 -1.8 -0.1 -1.1 -1.5 -1.4 0.2 -1.7 -1.9 -1.6 -1.8 -1.3 -1.3 -1.3 1.7 1.2 -1.0 -1.3 -1.1 -1.6
Heart disease (mother) 0.4 0.5 2.6 1.0 1.2 0.5 0.5 0.7 -0.1 1.3 1.6 -0.0 0.3 0.5 1.2 -0.2 0.3 -0.3 1.4 0.1 0.6 0.2 0.7 -0.5 0.1 0.9 -0.2 -0.3 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 6.0 0.3 0.1 -0.7 0.3 0.4 0.8 0.3 -0.4 1.0 -0.3 0.2 -0.5 -1.0 0.8 0.1 -0.1 1.3 0.1 0.4 -0.2 -0.7 -2.4 -0.6 0.6 -0.4 1.1
Whole body fat mass 1.6 6.9 36.4 -1.4 -1.5 -3.7 -1.7 -2.4 -1.1 -1.3 -2.7 -6.0 -0.3 -1.6 -3.6 -3.8 -0.5 -4.3 -1.9 1.0 -1.9 -1.8 -1.7 2.1 -4.2 -3.4 -1.5 -2.5 -0.2
Leg fat mass (right) 1.8 6.8 35.7 -1.3 -1.3 -3.9 -1.7 -2.3 -1.4 -1.2 -2.2 -6.0 -0.7 -1.6 -3.5 -4.2 -0.6 -3.8 -1.6 1.0 -1.9 -2.0 -1.7 1.9 -4.4 -3.3 -1.9 -2.7 -0.2
Arm predicted mass (right) 1.0 5.3 25.6 -1.9 -1.6 -1.9 -2.2 -2.4 -2.4 -1.5 -1.2 -4.3 -1.0 -1.8 -2.2 -5.1 -2.0 -2.1 -2.1 -1.3 -2.1 -2.4 -1.8 2.3 -1.0 -2.3 -2.5 -2.5 -2.1
Pulse rate, automated reading 1.1 3.4 7.9 -1.9 -1.7 -0.1 -1.9 -1.4 -2.1 -1.9 -0.6 -2.8 -1.0 -1.8 -1.0 -2.8 -2.2 -2.8 -1.7 -2.4 -1.6 -1.9 -1.5 2.0 1.5 -1.0 -2.0 -1.4 -2.2
Alcohol intake frequency. 2.6 6.0 8.0 -2.6 -2.6 -2.5 -2.8 -2.4 -2.8 -2.7 -1.7 -2.0 -2.3 -2.8 -2.2 -0.8 -2.8 -1.9 -2.6 -2.7 -2.5 -2.8 -2.6 2.8 0.9 -2.2 -2.8 -2.6 -2.7
Comparative height size at age 10 0.3 1.4 10.4 -0.6 -0.8 -1.4 -0.8 -1.3 -0.7 -0.8 -1.8 -1.9 -0.7 -0.5 -1.1 -1.1 -0.5 -3.2 -1.6 -0.1 -1.0 -0.8 -0.8 1.5 0.1 -0.9 -0.8 -0.9 -0.5
Number of full sisters 1.2 1.5 5.1 1.4 1.2 0.6 1.4 1.0 1.5 1.2 0.2 0.2 0.8 0.8 0.2 -0.1 1.8 0.6 1.3 2.1 1.0 1.1 1.2 -1.5 -2.3 0.2 1.3 0.7 2.0
Suffer from ‘nerves’ 0.4 0.7 13.1 0.1 0.0 -0.2 -0.1 0.2 -0.4 0.1 -0.0 3.6 -1.6 -0.1 -0.3 -0.5 -0.0 0.8 -0.0 0.3 -0.3 -0.4 -0.1 -0.1 -0.6 -0.3 -0.5 -0.3 0.4
Overall health rating 1.3 2.8 14.1 -1.2 -1.0 -2.0 -1.3 -1.4 -1.3 -1.1 -1.4 -2.5 -1.4 -1.3 -1.9 -3.8 -0.9 -2.9 -1.2 -0.2 -1.3 -1.5 -1.2 1.5 -2.1 -1.9 -1.5 -1.4 -0.4
Chest pain or discomfort 0.3 0.5 3.5 -0.2 0.1 0.5 -0.2 -0.1 -0.2 -0.1 0.2 -0.6 1.0 -0.1 0.7 0.2 -0.6 -1.7 0.1 -1.3 0.3 0.1 0.2 0.8 1.9 0.7 0.1 0.2 -0.7
Had major operations 1.1 1.3 8.1 -1.0 -0.9 -1.5 -1.0 -1.1 -1.0 -1.2 -1.1 -2.8 -0.7 -0.8 -1.1 -1.7 -0.9 -1.5 -0.8 -0.5 -0.8 -1.1 -0.8 1.0 -0.9 -1.1 -1.0 -1.0 -0.7
Age at last live birth 0.8 1.2 2.3 1.5 1.3 0.3 1.2 1.0 0.8 1.5 1.5 1.2 -0.3 1.1 1.1 0.5 1.3 1.2 1.2 1.4 1.0 0.9 1.0 -1.4 -0.1 1.0 0.6 0.4 1.3
Family relationship satisfaction 0.3 0.4 1.8 0.3 0.8 -0.0 0.2 0.8 -0.1 -0.1 1.1 -0.1 0.3 0.6 1.0 -0.3 -0.0 0.1 1.1 -0.1 1.1 0.3 1.1 0.1 0.4 1.3 -0.1 0.8 0.3
Leg pain on walking 1.9 2.3 6.6 1.4 1.8 2.3 1.5 1.7 1.3 1.7 2.6 1.0 1.9 1.7 1.8 0.3 1.0 1.0 1.7 0.6 1.6 1.4 1.6 -1.2 1.2 1.7 1.5 1.7 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 1.9 0.3 0.3 -0.2 0.2 -0.0 0.1 0.7 -0.2 1.4 0.2 0.1 0.0 0.8 0.2 1.0 0.4 0.2 -0.1 0.1 -0.1 -0.4 -0.5 -0.2 0.2 -0.1 0.2
Commuting to job workplace: Car/motor vehicle 4.7 5.4 8.8 -2.2 -2.3 -2.3 -2.4 -2.9 -2.5 -1.9 -2.3 -1.5 -2.4 -2.8 -2.8 -1.1 -2.1 -2.1 -2.3 -1.8 -2.8 -2.7 -2.7 1.9 -0.5 -3.0 -2.7 -2.7 -2.0
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.9 -0.5 -0.6 1.0 -0.3 -0.5 -0.5 -0.3 0.6 0.2 0.1 -0.6 0.0 1.7 -0.8 1.7 -0.6 -1.3 -0.6 -0.4 -0.6 0.3 1.3 -0.1 -0.3 0.1 -1.2
Medication: Aspirin 1.0 1.3 3.5 1.4 1.4 1.0 1.2 1.4 0.9 1.5 1.9 -0.0 1.1 1.4 1.3 0.3 1.1 -0.2 1.5 1.0 1.1 1.1 1.1 -0.7 0.5 1.2 0.9 1.0 1.0
Supplements: Vitamin C 0.5 0.6 5.5 0.5 0.8 0.8 0.1 0.0 -0.4 0.7 0.3 2.4 -0.8 0.4 0.8 1.1 -0.2 0.9 0.8 -0.4 0.5 -0.0 0.6 -0.3 1.4 0.9 -0.3 0.4 0.2
Knee pain experienced in last month 0.7 1.0 4.5 0.8 0.8 -0.2 0.9 1.0 1.3 0.8 0.8 -0.5 1.4 0.7 0.3 -1.4 1.1 -1.0 0.5 1.2 0.9 1.0 0.7 -0.8 -2.1 0.3 1.2 0.8 1.3
Hypertension (Self-reported) 1.3 3.5 20.3 -1.5 -1.4 -1.1 -1.6 -1.2 -2.1 -1.3 -0.3 -4.5 -1.0 -1.6 -1.3 -2.5 -1.7 -3.3 -1.4 -1.5 -1.6 -1.9 -1.6 1.9 0.2 -1.4 -2.2 -1.9 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.6 0.6 0.3 -0.2 0.5 0.3 0.5 0.4 -0.2 0.5 -0.4 0.3 -0.1 -0.6 0.7 0.1 0.3 1.2 0.2 0.3 0.3 -0.4 -1.3 -0.1 0.3 -0.1 0.8
Illnesses of father: Heart disease 1.6 2.3 5.8 1.4 1.6 2.4 1.4 1.7 1.1 1.3 2.1 1.1 1.5 1.4 1.9 1.5 1.0 1.5 1.9 0.6 1.6 1.3 1.7 -0.8 1.2 1.8 1.2 1.6 1.0
Illnesses of siblings: Diabetes 0.5 0.6 3.4 -0.8 -0.5 -0.5 -0.7 -0.6 -0.5 -0.7 -0.2 -1.8 0.3 -0.6 -0.8 -1.7 -0.6 -1.1 -0.7 -0.4 -0.5 -0.6 -0.4 1.0 -0.3 -0.9 -0.5 -0.3 -0.7
Smoking status: Previous 3.2 4.8 23.4 -1.9 -1.7 -1.5 -1.9 -2.0 -2.2 -1.5 -0.8 -4.8 -1.3 -2.0 -1.7 -3.4 -2.0 -3.1 -1.7 -1.8 -2.1 -2.2 -2.2 2.2 -0.0 -2.0 -2.3 -2.5 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.7 1.1 1.0 1.5 1.0 0.9 0.7 1.2 0.7 1.6 0.6 0.8 1.3 -0.1 0.8 0.4 0.7 0.4 0.8 0.9 1.0 -0.9 0.8 1.1 0.8 0.8 0.5
Whole body fat-free mass 0.8 4.5 21.2 -1.7 -1.5 -1.5 -2.0 -2.1 -2.1 -1.4 -0.8 -4.4 -0.5 -1.5 -1.9 -4.6 -1.8 -2.3 -2.0 -1.3 -1.9 -2.1 -1.6 2.3 -0.4 -2.0 -2.1 -2.2 -2.0
Leg fat-free mass (right) 0.5 2.7 19.4 -1.2 -1.1 -1.2 -1.4 -1.4 -1.2 -1.1 -0.5 -4.4 0.4 -0.9 -1.7 -3.6 -1.0 -2.1 -1.4 -0.4 -1.2 -1.3 -1.0 1.9 -0.7 -1.5 -1.3 -1.6 -1.3
Arm fat percentage (left) 1.3 5.2 36.0 -1.1 -1.1 -3.3 -1.1 -1.7 -0.4 -1.0 -2.2 -6.0 0.6 -1.1 -3.3 -2.8 0.0 -3.9 -1.2 1.4 -1.3 -1.2 -1.3 1.6 -4.3 -2.9 -0.8 -1.9 0.2
Average weekly red wine intake 1.5 2.2 5.2 -1.5 -1.7 -1.1 -1.6 -1.1 -1.6 -1.6 -0.4 -1.8 -1.2 -1.4 -1.3 -1.3 -1.5 -2.3 -1.3 -1.4 -1.5 -1.5 -1.6 1.5 1.1 -1.1 -1.6 -1.7 -1.7
Handedness (chirality/laterality): Left-handed 0.5 0.6 5.1 0.6 0.6 -0.0 0.7 0.4 0.8 0.8 0.2 2.3 -0.1 0.2 0.0 0.4 0.9 1.2 0.5 1.1 0.1 0.5 0.1 -0.8 -1.5 -0.4 0.8 0.2 0.8
Mood swings 0.1 0.2 1.9 0.2 0.3 -0.3 0.1 0.2 0.1 0.1 -0.1 1.0 -0.4 0.2 0.0 -1.4 0.2 0.2 0.3 0.5 0.2 0.0 0.5 0.0 -0.4 0.0 -0.0 0.2 0.4
Loneliness, isolation 0.5 0.7 7.1 -0.3 -0.3 -1.1 -0.3 -0.3 0.1 -0.8 -1.4 0.0 -0.9 -0.0 -1.1 -1.5 0.3 -0.1 -0.3 1.2 0.0 -0.2 0.2 0.1 -2.7 -0.7 -0.1 -0.1 0.9
Long-standing illness, disability or infirmity 1.7 2.6 16.2 -1.1 -0.7 -1.2 -1.3 -1.2 -1.2 -0.9 -0.9 -3.2 -0.7 -1.3 -1.5 -4.0 -1.0 -3.1 -0.7 -0.6 -1.0 -1.3 -0.8 1.7 -1.9 -1.5 -1.3 -1.1 -0.7
Ever had bowel cancer screening 0.8 0.9 4.8 -1.1 -0.9 -0.4 -0.9 -0.7 -0.9 -1.0 -0.1 -2.2 0.1 -0.8 -0.7 -0.6 -1.1 -1.1 -0.9 -1.3 -0.8 -0.8 -0.9 1.1 1.2 -0.7 -0.7 -0.6 -1.3
Diabetes diagnosed by doctor 0.2 0.3 1.7 -0.1 0.1 -1.3 -0.4 -0.1 -0.5 -0.1 -0.3 -0.7 -0.8 -0.0 -0.5 -1.1 -0.1 -0.1 -0.0 0.3 -0.0 -0.5 0.2 0.9 -0.9 -0.2 -0.7 -0.4 0.1
Ever had stillbirth, spontaneous miscarriage or termination 3.6 3.9 6.6 2.3 2.3 2.6 2.1 2.1 1.8 2.3 2.1 0.5 2.0 2.2 2.3 -0.2 1.9 2.1 2.1 1.7 2.0 2.0 2.2 -1.7 0.6 2.3 1.9 2.0 1.7
Friendships satisfaction 0.1 0.1 0.4 -0.0 0.1 -0.4 -0.0 0.4 -0.1 -0.5 0.1 -0.1 -0.1 0.2 0.3 0.2 -0.0 0.0 0.5 -0.0 0.6 0.1 0.5 0.0 -0.2 0.6 -0.1 0.2 0.2
Qualifications: nursing, teaching 0.8 1.2 3.2 1.3 1.2 1.3 1.2 0.9 0.7 1.3 0.8 0.9 0.5 1.5 1.5 0.8 0.9 1.8 1.4 0.7 1.1 0.9 1.1 -1.2 0.8 1.5 0.7 1.0 0.6
Commuting to job workplace: Walk 0.1 0.1 0.5 -0.4 -0.3 0.0 -0.2 0.3 -0.1 -0.6 0.2 0.1 -0.2 0.0 -0.0 -0.7 -0.2 -0.2 -0.2 -0.2 0.1 -0.0 0.1 0.5 0.5 0.2 -0.1 0.2 -0.2
Eye problems/disorders: Cataract 0.8 0.9 4.2 -1.1 -1.1 -1.1 -0.9 -0.5 -0.6 -1.5 -0.3 0.7 -0.6 -1.0 -0.9 2.1 -0.9 -1.1 -1.3 -0.8 -0.7 -0.7 -0.6 1.0 -0.1 -0.8 -0.5 -0.5 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 1.0 0.3 0.4 0.3 0.2 0.4 0.2 0.2 0.4 1.0 -0.1 -0.0 0.5 0.7 0.2 0.6 0.1 0.0 0.5 0.3 0.5 -0.1 -0.0 0.6 0.3 0.4 0.3
Medication for cholesterol 0.2 0.3 2.7 0.2 -0.0 0.5 0.2 0.3 0.1 0.1 0.3 0.5 0.6 0.4 0.5 1.1 0.1 0.9 -0.1 -0.1 0.1 0.3 0.3 -0.3 1.6 0.6 0.2 0.7 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 3.3 -0.2 -0.0 0.3 0.1 -0.2 0.3 -0.3 -0.0 -1.8 1.1 -0.0 -0.2 0.7 0.0 -0.2 0.0 -0.1 0.0 0.2 0.0 0.3 0.3 -0.1 0.4 0.5 -0.3
Back pain experienced in last month 1.6 2.4 11.3 -1.8 -1.5 -1.2 -1.5 -1.3 -1.5 -1.9 -1.5 -0.8 -1.4 -1.4 -1.4 -3.4 -1.6 -1.9 -1.4 -1.4 -1.2 -1.5 -1.2 1.5 -0.7 -1.3 -1.4 -1.4 -1.2
Mineral and other dietary supplements 0.3 0.4 2.9 -0.3 -0.4 -0.3 -0.0 0.1 0.4 -0.3 -0.4 -1.7 1.0 -0.2 -0.8 -1.0 0.2 -0.7 -0.5 0.3 -0.2 0.1 -0.2 0.4 -1.0 -0.6 0.4 0.2 0.1
Breast cancer (self-reported) 4.7 5.6 8.4 -2.6 -2.5 -2.8 -2.6 -2.6 -2.5 -2.6 -2.1 -1.6 -2.2 -2.9 -2.5 -0.5 -2.5 -1.9 -2.5 -2.4 -2.6 -2.5 -2.7 2.3 -0.2 -2.6 -2.5 -2.4 -2.4
Asthma (self-reported) 1.4 2.8 13.6 1.3 1.3 2.2 1.2 1.8 1.2 1.1 1.5 -2.6 1.6 1.3 1.7 -2.9 1.2 -3.7 1.0 1.0 1.4 1.3 1.4 -1.6 0.4 1.6 1.2 1.3 1.1
Osteoporosis (self-reported) 0.1 0.2 1.3 0.0 -0.3 0.1 -0.0 -0.3 -0.3 -0.0 0.2 -0.4 -0.3 0.1 -0.1 0.6 -0.2 -1.1 -0.4 -0.1 -0.5 -0.3 -0.4 0.4 1.0 -0.2 -0.3 0.3 -0.4
Osteoarthritis (self-reported) 0.8 1.1 3.2 1.0 0.9 0.6 1.1 0.8 1.1 1.3 1.4 -1.8 1.6 0.9 1.0 -0.9 1.0 -1.4 0.9 0.8 0.8 1.0 0.7 -0.7 -0.7 0.7 1.1 0.9 0.6
Medication: Aspirin 1.6 2.1 4.2 1.8 1.8 1.2 1.6 1.7 1.4 1.8 2.0 0.0 1.6 1.8 1.6 0.6 1.5 -0.1 1.8 1.4 1.5 1.5 1.5 -1.1 0.4 1.5 1.4 1.4 1.4
Medication: Gliclazide 0.5 0.5 1.5 0.9 0.8 0.4 0.8 1.0 0.7 0.9 1.2 -0.7 1.0 1.0 0.6 0.1 0.8 0.3 0.9 0.9 0.6 0.7 0.6 -0.1 -0.1 0.6 0.6 0.7 0.4
Illnesses of father: None of the above (group 1) 0.9 1.2 7.7 0.8 0.6 0.3 0.8 1.0 1.3 0.7 0.3 2.1 0.8 1.0 0.3 0.4 1.1 2.8 0.4 1.2 0.8 1.2 0.7 -1.1 -0.1 0.6 1.3 1.0 1.1
Smoking status: Current 0.4 0.7 1.6 0.8 0.9 0.2 0.7 0.8 0.4 0.9 1.3 -1.1 1.3 0.8 1.2 -1.1 0.4 -0.8 1.0 0.2 0.9 0.6 0.8 -0.5 0.7 1.1 0.5 0.7 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 4.6 -0.6 -0.7 -1.4 -0.7 -0.8 -0.8 -0.6 -0.1 -2.2 -0.6 -0.9 -0.9 -1.7 -0.6 -1.6 -0.5 -0.4 -1.0 -0.9 -1.0 0.7 -0.6 -1.0 -0.8 -1.0 -0.7
Whole body water mass 0.8 4.5 21.1 -1.7 -1.5 -1.5 -2.0 -2.1 -2.1 -1.4 -0.8 -4.4 -0.5 -1.5 -1.9 -4.6 -1.8 -2.2 -2.0 -1.2 -1.9 -2.1 -1.6 2.2 -0.5 -2.0 -2.1 -2.3 -2.0
Leg predicted mass (right) 0.6 3.1 20.0 -1.4 -1.2 -1.4 -1.5 -1.6 -1.4 -1.3 -0.6 -4.5 0.3 -1.0 -1.8 -3.7 -1.2 -2.2 -1.5 -0.6 -1.4 -1.5 -1.2 2.0 -0.7 -1.7 -1.4 -1.8 -1.4
Arm fat mass (left) 1.5 6.2 37.8 -1.5 -1.4 -3.2 -1.7 -2.3 -1.2 -1.3 -2.1 -6.1 0.1 -1.6 -3.4 -4.0 -0.7 -3.8 -1.7 0.6 -1.9 -1.8 -1.7 2.0 -3.7 -3.1 -1.5 -2.5 -0.6
Number of self-reported non-cancer illnesses 1.5 2.6 18.9 -0.8 -0.6 -0.7 -1.0 -0.9 -1.2 -0.4 0.3 -4.3 -0.4 -0.9 -0.8 -3.4 -1.0 -4.1 -0.7 -0.8 -1.1 -1.2 -1.0 1.2 -0.5 -1.0 -1.2 -1.2 -1.1
Average weekly champagne plus white wine intake 1.7 2.4 4.5 -1.6 -1.7 -1.7 -1.7 -1.5 -1.7 -1.7 -2.1 -0.7 -1.9 -1.5 -1.6 -0.3 -1.5 -0.7 -1.8 -1.3 -1.6 -1.6 -1.7 1.6 0.8 -1.3 -1.8 -1.7 -1.5
Miserableness 0.6 1.0 4.3 -0.8 -0.9 -1.4 -0.8 -0.7 -0.8 -0.9 -0.9 2.1 -1.6 -1.0 -1.2 -1.1 -0.6 0.2 -1.0 -0.2 -1.0 -1.0 -0.7 1.1 -0.7 -1.3 -0.9 -0.8 -0.2
Guilty feelings 0.3 0.5 10.5 -0.0 -0.1 -0.5 -0.2 0.1 0.0 -0.1 -0.1 3.2 -1.0 0.0 -0.2 0.1 -0.0 0.5 -0.4 0.1 -0.0 -0.1 -0.1 0.4 0.3 -0.1 0.0 0.2 0.3
Wears glasses or contact lenses 1.4 1.6 3.0 -1.5 -1.3 -1.2 -1.4 -1.4 -1.4 -1.4 -0.7 0.1 -1.1 -1.4 -1.0 -0.0 -1.5 -0.8 -1.3 -1.5 -1.5 -1.4 -1.6 1.7 0.2 -1.3 -1.3 -1.4 -1.6
Ever taken oral contraceptive pill 0.2 0.3 2.0 0.3 0.2 -0.3 0.2 0.4 0.5 0.3 0.4 1.2 -0.1 -0.1 -0.1 0.1 0.4 1.4 -0.1 0.5 0.1 0.3 0.1 -0.1 -1.4 -0.1 0.4 0.1 0.5
Hearing aid user 2.4 2.7 5.1 -1.7 -1.6 -1.8 -1.8 -1.8 -1.6 -1.6 -1.7 -0.3 -2.0 -2.0 -2.0 -2.3 -1.5 -0.7 -1.6 -1.2 -1.8 -1.8 -1.6 1.7 -1.3 -2.0 -1.6 -1.8 -1.2
Mother’s age at death 0.6 0.8 5.0 0.9 0.7 0.5 0.8 0.4 0.5 1.0 0.5 2.2 -0.0 0.7 0.5 1.8 0.7 1.4 0.8 0.7 0.5 0.5 0.6 -0.9 0.7 0.4 0.4 0.8 0.7
Financial situation satisfaction 2.3 2.8 5.9 2.2 2.0 0.3 2.0 1.5 1.7 1.9 1.4 1.4 1.1 2.0 1.6 0.6 2.1 1.5 1.8 2.4 1.7 1.7 1.7 -1.5 -0.5 1.5 1.5 1.4 2.2
Tinnitus: Yes, now most or all of the time 2.4 2.8 4.6 -2.0 -1.7 -0.3 -1.9 -1.9 -1.9 -1.8 -1.4 -0.6 -1.7 -1.8 -1.3 -1.7 -2.1 -1.9 -1.8 -2.1 -1.6 -1.8 -1.6 1.8 0.4 -1.5 -1.7 -1.3 -1.8
Commuting to job workplace: Public transport 3.3 3.9 7.3 2.0 2.2 1.8 2.2 2.3 2.0 1.8 2.2 0.5 1.8 2.1 2.0 1.5 2.0 1.2 2.7 2.0 2.3 2.1 2.3 -2.3 -0.5 2.0 2.0 1.8 2.1
Eye problems/disorders: Glaucoma 1.4 1.7 13.2 1.1 1.1 0.8 1.1 0.9 1.2 1.1 -0.0 3.6 0.1 1.1 0.7 2.3 1.2 1.7 0.8 1.2 1.1 1.1 1.1 -0.9 -0.8 0.8 1.1 1.0 1.6
Medication: Blood pressure 0.3 0.6 2.1 -0.6 -0.4 -0.7 -0.7 -0.7 -0.7 -0.4 -0.6 -1.4 -0.8 -0.7 -0.6 -1.4 -0.6 -1.4 -0.5 -0.3 -0.6 -0.8 -0.7 0.5 -0.8 -0.8 -0.8 -1.1 -0.3
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.6 -1.0 -0.6 -0.2 -0.9 -1.0 -1.1 -0.7 -0.6 -0.5 -0.5 -0.8 -0.6 -1.1 -1.2 -0.9 -0.6 -1.3 -0.9 -1.0 -0.8 1.3 0.5 -0.7 -1.0 -0.7 -1.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 3.6 -0.2 -0.3 -0.4 -0.6 -0.6 -1.0 -0.4 -0.4 1.7 -1.9 -0.2 -0.1 0.4 -0.6 0.8 -0.0 -0.3 -0.5 -0.8 -0.3 -0.1 0.1 -0.2 -1.1 -1.0 -0.2
High cholesterol (Self-reported) 0.3 0.6 5.1 0.2 0.5 0.4 0.1 0.1 -0.1 0.6 1.3 -2.3 0.8 0.1 0.3 -1.8 -0.2 -1.2 0.7 -0.4 0.0 -0.1 -0.2 0.5 0.5 -0.0 -0.0 -0.1 -0.3
Medication: Bendroflumethiazide 1.5 2.3 7.9 -1.1 -1.0 -1.8 -1.6 -1.1 -1.8 -1.0 -0.4 -2.5 -1.5 -1.4 -0.9 -2.8 -1.4 -2.3 -0.9 -1.1 -1.3 -1.6 -1.3 1.2 -0.5 -1.1 -1.9 -1.8 -1.4
Medication: Paracetamol 3.0 4.7 8.4 2.1 2.1 2.9 2.2 2.4 2.2 2.1 1.9 2.8 1.8 2.1 2.2 1.9 2.0 2.5 2.1 1.6 2.2 2.2 2.3 -1.9 0.9 2.2 2.3 2.7 1.9
Medication: Lisinopril 0.2 0.2 1.5 -0.1 -0.2 -0.3 -0.3 -0.3 -0.4 -0.2 -0.1 0.1 -0.8 -0.5 -0.5 0.9 -0.1 -0.6 -0.5 0.2 -0.3 -0.4 -0.1 0.3 -1.2 -0.5 -0.5 -0.4 0.2
Medication: Atorvastatin 0.6 0.7 1.8 1.1 1.3 1.0 0.8 0.7 0.5 1.3 0.9 0.2 0.3 1.0 1.2 -0.8 0.7 -0.4 1.1 0.6 0.9 0.7 1.0 -0.4 0.5 1.1 0.5 0.9 0.9
Illnesses of father: High blood pressure 0.4 0.5 2.8 -0.6 -0.6 -1.1 -0.7 -0.7 -0.5 -0.7 -0.7 -0.6 -0.7 -0.5 -0.7 -1.7 -0.5 -1.1 -0.5 -0.2 -0.5 -0.6 -0.7 0.7 -0.7 -0.7 -0.6 -0.8 -0.4
Alcohol drinker status: Never 4.7 5.6 10.9 -3.0 -3.0 -2.3 -2.7 -2.1 -2.2 -3.3 -2.0 -2.1 -1.5 -2.6 -2.2 0.0 -2.7 -1.8 -3.0 -2.7 -2.5 -2.2 -2.5 3.0 0.8 -2.1 -1.9 -1.8 -2.9
Ever smoked 1.3 2.3 17.5 -1.0 -0.8 -0.6 -1.1 -1.2 -1.4 -0.6 -0.2 -4.2 -0.4 -1.0 -0.9 -3.5 -1.1 -2.7 -0.9 -0.8 -1.1 -1.4 -1.1 1.2 -0.5 -1.1 -1.5 -1.3 -1.2
Basal metabolic rate 0.8 4.6 22.2 -1.6 -1.4 -1.8 -1.9 -2.1 -1.8 -1.3 -1.1 -4.7 -0.4 -1.5 -2.2 -4.7 -1.4 -2.6 -1.9 -0.7 -1.9 -2.0 -1.6 2.2 -1.3 -2.3 -2.0 -2.3 -1.6
Leg fat percentage (left) 1.7 6.2 29.4 -1.3 -1.3 -3.7 -1.5 -2.2 -1.1 -1.2 -2.3 -5.4 -0.8 -1.8 -3.5 -3.5 -0.4 -3.6 -1.5 1.1 -2.0 -1.9 -1.8 1.5 -4.6 -3.5 -1.6 -2.5 -0.0
Arm fat-free mass (left) 1.3 6.7 26.9 -2.1 -1.9 -2.2 -2.5 -2.7 -2.6 -1.8 -1.4 -4.6 -1.1 -2.1 -2.6 -5.2 -2.2 -2.8 -2.4 -1.5 -2.5 -2.7 -2.2 2.6 -1.1 -2.7 -2.7 -2.8 -2.3
Number of operations (self-reported) 1.7 2.5 11.3 -1.4 -1.1 -1.1 -1.4 -1.7 -1.6 -1.0 -1.3 -3.4 -1.0 -1.1 -1.0 -2.8 -1.5 -2.7 -1.3 -1.4 -1.2 -1.5 -1.1 1.7 -0.6 -1.1 -1.5 -1.2 -1.5
Average weekly beer plus cider intake 0.5 0.7 1.7 0.8 1.0 0.5 0.9 0.8 1.0 0.9 0.6 0.1 1.0 0.6 0.4 -0.5 1.0 0.8 1.0 1.1 0.8 0.8 1.1 -1.0 -1.1 0.3 0.9 0.7 1.3
Irritability 0.5 0.8 2.9 1.2 1.2 0.9 0.9 0.3 0.4 1.4 0.4 0.0 -0.2 0.7 0.3 -0.8 1.1 1.2 1.2 1.7 0.4 0.3 0.8 -1.0 -1.4 -0.0 0.1 0.2 1.3
Risk taking 0.2 0.3 1.5 0.7 0.7 -0.3 0.4 0.3 0.2 0.9 0.2 0.3 -0.2 0.4 0.3 -0.0 0.6 -0.2 0.7 0.8 0.6 0.2 0.8 -0.6 -1.2 0.4 -0.1 0.1 0.8
Ever had prostate specific antigen (PSA) test 0.5 0.5 4.8 -0.4 -0.3 0.1 -0.3 -0.6 -0.5 -0.3 0.5 -2.2 0.5 -0.6 0.1 -0.4 -0.7 -0.8 -0.3 -1.1 -0.6 -0.4 -0.7 0.7 1.2 -0.3 -0.3 -0.3 -1.1
Fractured/broken bones in last 5 years 0.7 0.8 3.7 0.8 0.7 -0.3 0.8 0.6 0.9 0.8 0.0 -1.8 0.6 0.8 0.1 -0.6 1.2 -0.1 0.9 1.5 0.8 0.8 0.7 -0.9 -1.9 0.4 0.7 0.7 1.2
Age started oral contraceptive pill 3.5 4.4 6.2 -2.4 -2.2 -2.2 -2.4 -2.1 -2.3 -2.2 -1.5 -1.0 -2.5 -2.1 -2.4 -1.0 -2.3 -2.3 -2.2 -1.8 -2.3 -2.4 -2.2 2.2 -0.7 -2.3 -2.4 -2.3 -2.0
Diastolic blood pressure, automated reading 1.0 3.1 16.5 -1.3 -1.2 -1.6 -1.5 -1.2 -1.6 -1.1 -0.5 -4.1 -0.7 -1.5 -1.6 -2.4 -1.4 -4.0 -1.3 -1.1 -1.5 -1.6 -1.7 1.4 -0.5 -1.5 -1.7 -1.8 -1.2
Ever depressed for a whole week 1.4 1.8 4.7 1.3 1.1 1.0 1.5 1.7 1.9 1.0 1.0 -0.5 2.2 1.4 0.9 0.5 1.7 0.1 1.0 1.7 1.3 1.7 1.2 -1.3 -0.2 1.0 1.9 1.3 1.4
Unable to work because of sickness or disability 1.9 2.5 6.5 -1.6 -1.4 -1.2 -1.5 -1.6 -1.4 -1.0 -0.6 -1.0 -1.2 -2.0 -1.9 -2.5 -1.4 -1.4 -1.4 -1.3 -2.0 -1.7 -1.8 1.6 -0.8 -2.4 -1.4 -1.7 -1.5
Commuting to job workplace: Cycle 1.2 1.4 2.6 1.3 1.3 1.6 1.5 1.2 1.2 1.3 1.6 0.4 1.0 1.4 1.1 0.7 1.3 1.2 1.4 1.3 1.1 1.1 1.1 -1.1 -0.3 1.0 1.2 1.3 1.1
Myopia 2.7 3.9 5.9 -2.2 -2.2 -0.9 -2.2 -2.0 -2.3 -2.4 -1.4 -1.2 -2.0 -1.9 -1.5 -1.1 -2.4 -1.8 -1.7 -2.4 -2.1 -2.1 -2.1 2.0 2.1 -1.5 -2.2 -2.1 -2.4
Vascular/heart problems diagnosed by doctor 0.9 2.5 24.5 0.7 0.5 1.0 1.0 0.8 1.5 0.4 -0.1 5.0 0.5 0.9 0.8 2.8 1.1 3.2 0.5 0.8 1.0 1.4 1.0 -1.4 0.3 0.9 1.7 1.5 1.1
Cholesterol lowering medication 0.3 0.4 2.5 -0.1 -0.0 -0.6 0.0 -0.3 0.2 0.0 -0.1 -1.0 0.1 -0.4 -0.8 -1.2 0.1 -1.6 -0.0 0.3 -0.4 -0.2 -0.5 0.4 -1.4 -1.0 0.1 -0.8 0.4
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 3.9 -0.5 -0.2 -0.6 -0.4 -0.7 -0.3 -0.4 -0.9 -1.6 -0.7 -0.6 -0.7 0.1 -0.2 -2.0 -0.3 0.1 -0.4 -0.5 -0.5 0.1 -1.8 -0.9 -0.3 -0.6 -0.1
Pain experienced in last month 0.3 0.4 4.1 0.5 0.5 1.0 0.5 0.2 0.3 0.5 0.8 -0.8 0.9 0.2 0.7 2.0 0.3 0.6 0.6 0.1 0.2 0.4 0.2 -0.7 0.9 0.4 0.4 0.3 -0.0
Supplements: Calcium 0.2 0.2 1.3 0.0 0.1 -1.1 -0.2 -0.5 -0.1 0.1 -0.7 0.7 -0.7 -0.0 -0.2 0.9 0.0 -0.1 0.0 0.2 -0.0 -0.2 -0.0 0.4 -0.7 -0.2 -0.2 -0.3 0.3
Basal cell carcinoma (self-reported) 0.4 0.4 1.9 0.8 1.0 0.6 0.6 0.3 0.1 1.0 0.7 0.5 -0.2 0.7 0.9 -0.2 0.4 0.7 1.4 0.5 0.6 0.2 0.9 -0.7 -0.4 0.7 -0.0 0.0 0.7
Heart attack/myocardial infarction (self-reported) 0.7 1.0 5.8 0.8 0.8 -0.7 0.7 0.5 0.9 0.8 -0.6 -1.6 0.6 0.8 -0.1 -1.0 1.2 -0.8 0.9 1.6 0.7 0.7 0.6 -0.7 -2.4 0.1 0.7 0.3 1.5
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.7 -0.4 -0.4 -0.9 -0.6 -0.6 -0.5 -0.2 0.0 0.4 -0.9 -1.0 -0.8 -0.6 -0.3 -0.6 -0.5 -0.2 -0.7 -0.7 -0.5 0.7 -1.1 -1.1 -0.6 -1.3 -0.0
Heart disease (siblings) 0.4 0.5 6.3 0.5 0.7 -0.1 0.5 0.5 0.3 0.8 0.8 0.4 0.4 0.4 0.7 1.2 0.4 2.5 0.7 0.1 0.6 0.4 0.5 -0.4 -0.0 0.6 0.3 0.4 0.1
Alcohol drinker status: Previous 0.2 0.2 1.5 -0.3 -0.0 -0.4 -0.5 -0.1 -0.9 -0.4 0.1 -0.3 -1.2 -0.3 -0.2 -0.2 -0.6 -0.5 -0.0 -0.4 -0.1 -0.7 -0.1 0.3 0.4 -0.0 -1.1 -0.6 -0.2
Pack years of smoking 1.2 1.8 3.0 -1.5 -1.4 -1.7 -1.6 -1.5 -1.5 -1.6 -1.3 -0.6 -1.3 -1.4 -1.4 0.8 -1.4 -0.6 -1.4 -1.3 -1.3 -1.5 -1.2 1.4 0.3 -1.3 -1.5 -1.3 -1.2
Impedance of whole body 0.9 4.6 28.0 1.8 1.2 0.7 2.0 1.7 2.5 1.2 -1.0 4.6 0.3 1.5 1.0 5.3 2.4 -0.2 1.1 2.2 1.7 2.2 1.4 -1.8 -0.3 1.4 2.4 2.4 2.7
Leg fat mass (left) 1.9 7.5 37.0 -1.6 -1.6 -4.0 -1.9 -2.6 -1.6 -1.4 -2.3 -6.1 -0.9 -1.9 -3.7 -4.3 -0.8 -3.9 -1.9 0.7 -2.2 -2.2 -2.0 2.2 -4.2 -3.5 -2.1 -2.9 -0.5
Arm predicted mass (left) 1.1 5.6 23.1 -1.9 -1.7 -1.9 -2.3 -2.5 -2.4 -1.6 -1.1 -4.3 -1.0 -2.0 -2.3 -4.8 -2.0 -2.4 -2.2 -1.4 -2.3 -2.5 -2.0 2.3 -1.0 -2.5 -2.5 -2.7 -2.1