Best TWAS P=3.46e-18 · Best GWAS P=4.95e-25 conditioned to 1.07e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | SLX4 | 0.33 | 0.14 | lasso | 3 | 0.10 | 6.8e-04 | 5.1 | -5.3 | 1.2e-07 | -0.01 | 0.16 | 0.05 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | NLRC3 | 0.50 | 0.18 | enet | 30 | 0.33 | 1.6e-09 | 3.3 | -6.1 | 1.0e-09 | 0.03 | 0.44 | 0.06 | TRUE |
| 3 | GTEx | Brain Hippocampus | CLUAP1 | 0.37 | 0.10 | lasso | 5 | 0.09 | 4.9e-03 | 4.8 | 5.6 | 2.5e-08 | 0.02 | 0.17 | 0.06 | FALSE |
| 4 | GTEx | Lung | ZSCAN32 | 0.08 | 0.02 | lasso | 3 | 0.02 | 6.3e-03 | 5.1 | 5.2 | 2.6e-07 | 0.04 | 0.07 | 0.45 | FALSE |
| 5 | GTEx | Nerve Tibial | UBN1 | 0.14 | 0.12 | lasso | 4 | 0.11 | 5.6e-08 | 5.2 | -5.2 | 2.3e-07 | -0.04 | 0.03 | 0.97 | TRUE |
| 6 | GTEx | Skin Sun Exposed Lower leg | CLUAP1 | 0.34 | 0.25 | lasso | 6 | 0.27 | 1.1e-22 | 5.1 | 5.4 | 5.1e-08 | 0.04 | 1.00 | 0.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | RP11-462G12.1 | 0.11 | 0.07 | enet | 18 | 0.06 | 1.1e-08 | -9.9 | -8.7 | 3.5e-18 | 0.86 | 0.00 | 1.00 | TRUE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NLRC3 | 0.05 | 0.01 | blup | 39 | 0.02 | 9.8e-03 | 5.2 | -5.5 | 3.5e-08 | -0.09 | 0.01 | 0.86 | FALSE |
| 9 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | NLRC3 | 0.07 | 0.02 | blup | 39 | 0.01 | 7.4e-02 | -3.6 | -5.4 | 7.0e-08 | -0.12 | 0.02 | 0.61 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | NLRC3 | 0.14 | 0.04 | blup | 39 | 0.10 | 1.9e-06 | 3.7 | -5.2 | 2.2e-07 | -0.09 | 0.03 | 0.85 | FALSE |