[Hub]/) : Traits : Body mass index (BMI) : ← →

chr16:19,016,966-21,147,999

Best TWAS P=4.55e-16 · Best GWAS P=5.32e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Adipose Subcutaneous	GPRC5B	0.07	0.04	lasso	4	0.03	1.3e-03	-7.8	8.1	4.5e-16	-0.96	0.00	0.99	TRUE
68	GTEx	Skin Sun Exposed Lower leg	ACSM5	0.21	0.04	lasso	9	0.07	3.6e-06	1.1	-5.2	1.6e-07	0.16	0.27	0.35	TRUE
103	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCK	0.03	0.03	lasso	3	0.02	7.2e-04	-6.6	-6.7	2.4e-11	0.94	0.00	0.99	FALSE
29	GTEx	Breast Mammary Tissue (Male)	AC002550.5	0.37	0.29	lasso	3	0.35	4.8e-09	-6.5	-6.6	5.7e-11	0.90	0.05	0.95	FALSE
82	GTEx	Whole Blood	KNOP1	0.08	0.04	lasso	3	0.04	1.7e-04	-5.4	-6.5	1.1e-10	0.86	0.29	0.69	FALSE
38	GTEx	Colon Transverse	AC002550.5	0.35	0.36	enet	15	0.41	5.0e-21	-5.4	-6.4	1.7e-10	0.81	0.86	0.14	FALSE
39	GTEx	Esophagus Gastroesophageal Junction	KNOP1	0.51	0.44	enet	22	0.56	5.3e-24	-6.0	-6.4	1.8e-10	0.84	0.11	0.89	FALSE
49	GTEx	Liver	KNOP1	0.23	0.21	lasso	7	0.25	1.4e-07	-5.1	-6.4	1.8e-10	0.81	0.51	0.40	FALSE
66	GTEx	Skin Not Sun Exposed Suprapubic	AC002550.5	0.44	0.43	enet	24	0.43	1.2e-25	-5.2	-6.3	2.6e-10	0.79	0.99	0.01	FALSE
60	GTEx	Pancreas	KNOP1	0.42	0.37	lasso	11	0.40	4.2e-18	-5.1	-6.3	2.8e-10	0.84	0.60	0.40	FALSE
35	GTEx	Colon Sigmoid	KNOP1	0.32	0.35	lasso	6	0.32	4.9e-12	-5.4	-6.2	4.1e-10	0.80	0.21	0.78	FALSE
40	GTEx	Esophagus Gastroesophageal Junction	AC002550.5	0.62	0.54	enet	35	0.63	4.4e-29	-5.1	-6.2	4.3e-10	0.77	0.84	0.16	FALSE
10	GTEx	Artery Coronary	KNOP1	0.28	0.25	lasso	7	0.32	2.5e-11	-5.4	-6.2	5.9e-10	0.82	0.08	0.92	FALSE
88	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCK	0.05	0.02	blup	73	0.03	1.0e-03	-6.8	-6.2	6.0e-10	0.84	0.01	0.97	FALSE
8	GTEx	Artery Aorta	KNOP1	0.50	0.48	lasso	8	0.49	4.0e-30	-5.4	-6.2	6.6e-10	0.76	1.00	0.00	FALSE
73	GTEx	Stomach	KNOP1	0.28	0.21	lasso	6	0.21	1.8e-10	-4.7	-6.1	9.1e-10	0.77	0.09	0.91	FALSE
61	GTEx	Pancreas	AC002550.5	0.37	0.36	lasso	12	0.36	3.2e-16	-5.4	-6.1	9.7e-10	0.76	0.92	0.08	FALSE
28	GTEx	Breast Mammary Tissue	AC002550.5	0.37	0.49	enet	13	0.50	3.3e-29	-5.4	-6.1	1.1e-09	0.80	1.00	0.00	FALSE
30	GTEx	Breast Mammary Tissue (Female)	AC002550.5	0.36	0.26	enet	19	0.33	1.3e-10	-6.0	-6.1	1.1e-09	0.75	0.38	0.62	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C16orf88	0.10	0.10	lasso	3	0.13	3.7e-14	-6.0	-6.1	1.3e-09	0.80	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCK	0.03	0.03	blup	73	0.03	1.6e-07	-5.1	-6.1	1.4e-09	0.81	0.17	0.83	FALSE
94	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C16orf88	0.22	0.08	lasso	3	0.08	2.0e-09	-6.0	-6.0	1.8e-09	0.82	0.00	1.00	FALSE
50	GTEx	Liver	AC002550.5	0.43	0.42	enet	13	0.47	1.1e-14	-5.1	-6.0	1.9e-09	0.85	0.92	0.08	FALSE
97	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf88	0.07	0.05	lasso	2	0.05	7.7e-04	-6.0	-6.0	1.9e-09	0.83	0.00	0.94	FALSE
58	GTEx	Ovary	KNOP1	0.61	0.64	lasso	7	0.57	4.4e-17	-5.4	-6.0	2.1e-09	0.77	0.74	0.26	FALSE
105	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C16orf88	0.34	0.21	lasso	4	0.17	3.1e-07	-6.0	-6.0	2.1e-09	0.82	0.00	1.00	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	IQCK	0.04	0.01	blup	73	0.01	1.8e-02	-5.4	-6.0	2.4e-09	0.77	0.06	0.51	FALSE
95	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQCK	0.04	0.03	lasso	2	0.04	7.5e-05	-5.3	-6.0	2.6e-09	0.69	0.12	0.64	FALSE
11	GTEx	Artery Coronary	AC002550.5	0.30	0.34	enet	11	0.37	1.5e-13	-5.4	-6.0	2.7e-09	0.79	0.45	0.55	FALSE
37	GTEx	Colon Transverse	KNOP1	0.22	0.23	enet	19	0.24	9.8e-12	-5.4	-5.9	2.7e-09	0.81	0.47	0.53	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	GPRC5B	0.06	0.01	blup	38	0.01	2.4e-02	-5.2	-5.9	2.8e-09	0.67	0.01	0.08	FALSE
80	GTEx	Vagina	KNOP1	0.43	0.35	lasso	5	0.36	4.2e-09	-5.4	-5.9	2.9e-09	0.74	0.46	0.53	FALSE
6	GTEx	Adrenal Gland	KNOP1	0.40	0.34	lasso	4	0.40	1.1e-15	-6.0	-5.9	3.0e-09	0.79	0.64	0.36	FALSE
27	GTEx	Brain Putamen basal ganglia	AC002550.5	0.59	0.48	enet	23	0.58	1.2e-16	-5.4	-5.9	3.3e-09	0.62	0.99	0.00	FALSE
76	GTEx	Testis	AC002550.5	0.49	0.57	lasso	5	0.56	7.7e-30	-5.4	-5.9	3.3e-09	0.77	1.00	0.00	FALSE
9	GTEx	Artery Aorta	AC002550.5	0.52	0.52	lasso	7	0.49	1.9e-30	-5.4	-5.9	3.7e-09	0.75	1.00	0.00	FALSE
43	GTEx	Esophagus Muscularis	KNOP1	0.47	0.51	lasso	10	0.56	1.9e-40	-5.4	-5.9	4.8e-09	0.74	1.00	0.00	FALSE
7	GTEx	Adrenal Gland	AC002550.5	0.37	0.39	enet	28	0.40	1.6e-15	-5.4	-5.8	5.2e-09	0.75	0.97	0.03	FALSE
51	GTEx	Lung	KNOP1	0.34	0.48	lasso	8	0.49	4.0e-42	-5.4	-5.8	5.3e-09	0.76	1.00	0.00	FALSE
67	GTEx	Skin Sun Exposed Lower leg	KNOP1	0.33	0.47	lasso	9	0.48	5.4e-44	-5.4	-5.8	6.0e-09	0.76	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	AC002550.5	0.41	0.50	enet	17	0.52	7.9e-49	-5.3	-5.8	7.5e-09	0.74	1.00	0.00	FALSE
64	GTEx	Prostate	AC002550.5	0.49	0.25	lasso	8	0.33	5.7e-09	-5.4	-5.8	7.9e-09	0.74	0.97	0.03	FALSE
19	GTEx	Brain Frontal Cortex BA9	KNOP1	0.43	0.33	lasso	14	0.30	1.0e-08	-5.4	-5.8	8.1e-09	0.76	0.94	0.02	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf88	0.10	0.08	lasso	3	0.08	7.1e-17	-5.4	-5.8	8.3e-09	0.76	0.04	0.96	FALSE
71	GTEx	Spleen	KNOP1	0.45	0.36	lasso	7	0.41	1.2e-11	-5.4	-5.7	9.3e-09	0.74	0.34	0.66	FALSE
4	GTEx	Adipose Visceral Omentum	KNOP1	0.39	0.52	lasso	3	0.53	9.1e-32	-5.4	-5.7	9.5e-09	0.75	1.00	0.00	FALSE
74	GTEx	Stomach	AC002550.5	0.36	0.26	lasso	7	0.32	4.8e-16	-5.4	-5.7	9.6e-09	0.73	0.93	0.07	FALSE
13	GTEx	Artery Tibial	AC002550.5	0.31	0.36	lasso	8	0.39	6.8e-32	-5.4	-5.7	1.1e-08	0.73	1.00	0.00	FALSE
69	GTEx	Skin Sun Exposed Lower leg	AC002550.5	0.38	0.56	lasso	6	0.57	8.6e-58	-5.4	-5.7	1.4e-08	0.74	1.00	0.00	FALSE
79	GTEx	Uterus	AC002550.5	0.51	0.40	lasso	12	0.36	2.3e-08	-5.4	-5.7	1.4e-08	0.76	0.35	0.59	FALSE
41	GTEx	Esophagus Mucosa	KNOP1	0.31	0.43	lasso	5	0.43	5.6e-31	-5.4	-5.7	1.5e-08	0.74	1.00	0.00	FALSE
59	GTEx	Ovary	AC002550.5	0.66	0.56	lasso	4	0.47	3.6e-13	-5.4	-5.7	1.5e-08	0.72	0.87	0.13	FALSE
47	GTEx	Heart Left Ventricle	KNOP1	0.34	0.48	lasso	2	0.44	2.3e-25	-5.4	-5.6	1.7e-08	0.73	1.00	0.00	FALSE
24	GTEx	Brain Hypothalamus	AC002550.5	0.37	0.47	lasso	2	0.46	3.1e-12	-5.4	-5.6	2.0e-08	0.73	0.54	0.46	FALSE
55	GTEx	Muscle Skeletal	AC002550.5	0.35	0.53	lasso	6	0.52	3.2e-59	-5.4	-5.6	2.0e-08	0.73	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C16orf88	0.08	0.08	lasso	2	0.08	4.9e-07	-5.4	-5.6	2.0e-08	0.71	0.03	0.97	FALSE
62	GTEx	Pituitary	KNOP1	0.40	0.36	lasso	3	0.30	3.1e-08	-5.4	-5.6	2.1e-08	0.76	0.52	0.42	FALSE
53	GTEx	Lung	AC002550.5	0.43	0.55	lasso	9	0.54	6.4e-48	-5.4	-5.6	2.2e-08	0.73	1.00	0.00	FALSE
18	GTEx	Brain Cortex	AC002550.5	0.50	0.46	lasso	6	0.46	3.9e-14	-5.4	-5.6	2.3e-08	0.71	1.00	0.00	FALSE
65	GTEx	Skin Not Sun Exposed Suprapubic	KNOP1	0.37	0.43	lasso	3	0.41	5.0e-24	-5.1	-5.6	2.3e-08	0.74	1.00	0.00	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	IQCK	0.09	0.04	lasso	6	0.04	4.9e-05	-5.2	-5.6	2.4e-08	0.73	0.16	0.83	FALSE
108	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C16orf88	0.09	0.08	lasso	2	0.06	4.2e-03	-5.4	-5.6	2.7e-08	0.68	0.03	0.78	FALSE
77	GTEx	Thyroid	KNOP1	0.35	0.41	enet	11	0.43	4.7e-36	-5.4	-5.5	2.9e-08	0.71	1.00	0.00	FALSE
92	The Cancer Genome Atlas	Colon Adenocarcinoma	C16orf88	0.10	0.04	blup	37	0.04	1.6e-03	-5.4	-5.5	3.1e-08	0.69	0.03	0.92	FALSE
75	GTEx	Testis	KNOP1	0.37	0.34	lasso	5	0.30	8.1e-14	-5.4	-5.5	3.2e-08	0.70	0.98	0.02	FALSE
44	GTEx	Esophagus Muscularis	AC002550.5	0.40	0.49	lasso	7	0.47	1.4e-31	-5.4	-5.5	3.4e-08	0.71	1.00	0.00	FALSE
25	GTEx	Brain Nucleus accumbens basal ganglia	KNOP1	0.34	0.38	lasso	5	0.37	1.0e-10	-5.2	-5.5	3.5e-08	0.74	0.92	0.07	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	IQCK	0.05	0.04	lasso	3	0.03	4.3e-04	-5.4	-5.5	3.7e-08	0.68	0.52	0.14	FALSE
32	GTEx	Cells EBV-transformed lymphocytes	AC002550.5	0.81	0.65	lasso	15	0.64	2.9e-26	-5.4	-5.5	3.8e-08	0.70	1.00	0.00	FALSE
45	GTEx	Heart Atrial Appendage	KNOP1	0.43	0.45	lasso	3	0.44	6.5e-22	-5.4	-5.5	4.6e-08	0.70	1.00	0.00	FALSE
34	GTEx	Cells Transformed fibroblasts	AC002550.5	0.12	0.10	enet	15	0.10	4.3e-08	-5.3	-5.5	4.9e-08	0.70	0.99	0.01	FALSE
26	GTEx	Brain Nucleus accumbens basal ganglia	AC002550.5	0.36	0.41	enet	20	0.42	2.2e-12	-5.4	-5.4	5.2e-08	0.68	0.98	0.02	FALSE
83	GTEx	Whole Blood	AC002550.5	0.15	0.10	lasso	4	0.10	6.3e-10	-5.4	-5.4	5.3e-08	0.69	0.98	0.02	FALSE
20	GTEx	Brain Frontal Cortex BA9	AC002550.5	0.53	0.40	enet	15	0.43	9.0e-13	-5.4	-5.4	5.6e-08	0.71	1.00	0.00	FALSE
84	METSIM	Adipose	KNOP1	0.15	0.23	bslmm	442	0.24	9.4e-35	-5.4	-5.4	5.9e-08	0.71	1.00	0.00	FALSE
48	GTEx	Heart Left Ventricle	AC002550.5	0.38	0.41	lasso	2	0.38	2.8e-21	-5.4	-5.4	6.0e-08	0.69	1.00	0.00	FALSE
104	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C16orf88	0.12	0.06	lasso	7	0.05	2.8e-03	-5.4	-5.4	6.0e-08	0.68	0.04	0.83	FALSE
46	GTEx	Heart Atrial Appendage	AC002550.5	0.46	0.50	lasso	2	0.49	7.4e-25	-5.4	-5.4	6.1e-08	0.69	1.00	0.00	FALSE
81	GTEx	Vagina	AC002550.5	0.47	0.24	lasso	4	0.38	1.0e-09	-5.4	-5.4	6.1e-08	0.71	0.80	0.20	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf88	0.22	0.30	lasso	8	0.30	1.2e-34	-5.4	-5.4	6.1e-08	0.69	0.04	0.96	FALSE
17	GTEx	Brain Cerebellum	AC002550.5	0.49	0.52	lasso	2	0.52	9.7e-18	-5.4	-5.4	6.2e-08	0.69	1.00	0.00	FALSE
70	GTEx	Small Intestine Terminal Ileum	AC002550.5	0.42	0.32	lasso	2	0.31	1.2e-07	-5.4	-5.4	6.2e-08	0.69	0.55	0.32	FALSE
85	ROSMAP	Brain Pre-frontal Cortex	KNOP1	0.56	0.72	lasso	6	0.72	3.0e-135	-5.4	-5.4	6.2e-08	0.68	1.00	0.00	FALSE
15	GTEx	Brain Caudate basal ganglia	AC002550.5	0.64	0.42	lasso	2	0.43	1.0e-13	-5.4	-5.4	6.4e-08	0.69	1.00	0.00	FALSE
54	GTEx	Muscle Skeletal	KNOP1	0.29	0.45	lasso	6	0.44	7.0e-48	-5.4	-5.4	6.5e-08	0.70	1.00	0.00	FALSE
57	GTEx	Nerve Tibial	AC002550.5	0.39	0.55	lasso	4	0.55	2.0e-45	-5.4	-5.4	6.5e-08	0.69	1.00	0.00	FALSE
56	GTEx	Nerve Tibial	KNOP1	0.44	0.59	lasso	4	0.59	4.6e-51	-5.4	-5.4	6.7e-08	0.69	1.00	0.00	FALSE
14	GTEx	Brain Caudate basal ganglia	KNOP1	0.58	0.37	lasso	2	0.39	3.7e-12	-5.4	-5.4	6.9e-08	0.69	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	AC002550.5	0.40	0.51	lasso	1	0.50	8.1e-30	-5.4	-5.4	7.0e-08	0.69	1.00	0.00	FALSE
23	GTEx	Brain Hypothalamus	KNOP1	0.31	0.37	lasso	2	0.34	1.1e-08	-5.4	-5.4	7.0e-08	0.70	0.29	0.66	FALSE
33	GTEx	Cells Transformed fibroblasts	KNOP1	0.07	0.08	lasso	5	0.08	2.5e-06	-5.4	-5.4	7.0e-08	0.69	0.90	0.03	FALSE
42	GTEx	Esophagus Mucosa	AC002550.5	0.38	0.52	lasso	3	0.51	2.6e-39	-5.4	-5.4	7.0e-08	0.71	1.00	0.00	FALSE
12	GTEx	Artery Tibial	KNOP1	0.16	0.22	lasso	3	0.22	8.9e-17	-5.4	-5.4	7.1e-08	0.69	1.00	0.00	FALSE
93	The Cancer Genome Atlas	Glioblastoma Multiforme	C16orf88	0.34	0.07	lasso	3	0.12	1.5e-04	-6.0	-5.4	7.2e-08	0.78	0.00	0.93	FALSE
21	GTEx	Brain Hippocampus	KNOP1	0.25	0.25	lasso	7	0.14	3.2e-04	-5.3	-5.4	7.6e-08	0.70	0.57	0.08	FALSE
1	GTEx	Adipose Subcutaneous	KNOP1	0.26	0.38	lasso	6	0.40	9.0e-35	-5.3	-5.4	8.0e-08	0.69	1.00	0.00	FALSE
22	GTEx	Brain Hippocampus	AC002550.5	0.25	0.24	lasso	4	0.22	6.9e-06	-5.1	-5.4	8.0e-08	0.70	0.56	0.12	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	C16orf88	0.15	0.12	blup	37	0.12	1.1e-13	-5.4	-5.4	8.1e-08	0.70	0.04	0.96	FALSE
72	GTEx	Spleen	AC002550.5	0.53	0.44	enet	12	0.46	2.9e-13	-5.4	-5.4	8.5e-08	0.70	0.90	0.10	FALSE
78	GTEx	Uterus	KNOP1	0.29	0.22	enet	10	0.18	1.7e-04	-5.4	-5.3	9.1e-08	0.73	0.12	0.62	FALSE
86	ROSMAP	Brain Pre-frontal Cortex	CTD-2380F24.1	0.20	0.29	lasso	1	0.29	2.4e-37	-5.3	5.3	9.5e-08	-0.69	1.00	0.00	FALSE
36	GTEx	Colon Sigmoid	AC002550.5	0.41	0.38	lasso	2	0.35	4.2e-13	-5.4	-5.3	9.8e-08	0.65	0.92	0.08	FALSE
31	GTEx	Cells EBV-transformed lymphocytes	KNOP1	0.70	0.58	lasso	7	0.59	2.1e-23	-5.1	-5.3	1.2e-07	0.70	1.00	0.00	FALSE
91	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C16orf88	0.16	0.09	enet	10	0.14	2.2e-07	-5.2	-5.3	1.2e-07	0.74	0.03	0.97	FALSE
52	GTEx	Lung	GPRC5B	0.08	0.05	lasso	4	0.06	2.4e-05	-5.1	5.3	1.3e-07	-0.73	0.85	0.08	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	C16orf88	0.18	0.14	lasso	4	0.14	2.4e-14	-5.4	-5.3	1.3e-07	0.69	0.04	0.96	FALSE
99	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C16orf88	0.10	0.12	lasso	2	0.08	9.5e-05	-5.3	-5.3	1.5e-07	0.69	0.02	0.96	FALSE
16	GTEx	Brain Cerebellar Hemisphere	AC002550.5	0.50	0.44	lasso	8	0.43	2.0e-12	-5.1	-5.2	1.7e-07	0.69	1.00	0.00	FALSE
63	GTEx	Pituitary	AC002550.5	0.52	0.53	lasso	3	0.52	3.8e-15	-5.4	-5.2	1.9e-07	0.69	1.00	0.00	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf88	0.15	0.10	lasso	4	0.10	8.2e-12	-5.4	-5.2	2.2e-07	0.66	0.04	0.96	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf88	0.20	0.18	blup	37	0.19	6.3e-18	-5.4	-5.2	2.5e-07	0.68	0.04	0.96	FALSE