Best TWAS P=2.46e-09 · Best GWAS P=1.9e-18 conditioned to 1.79e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SRR | 0.16 | 0.16 | lasso | 9 | 0.18 | 1.9e-14 | -4.9 | 5.7 | 1.3e-08 | -0.07 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adrenal Gland | SRR | 0.38 | 0.37 | lasso | 6 | 0.38 | 8.1e-15 | -4.3 | 5.3 | 9.9e-08 | -0.06 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Liver | SRR | 0.31 | 0.00 | lasso | 7 | 0.00 | 3.0e-01 | -6.5 | 5.6 | 1.9e-08 | -0.40 | 0.06 | 0.15 | TRUE |
| 4 | METSIM | Adipose | SRR | 0.07 | 0.07 | enet | 21 | 0.06 | 4.4e-09 | -4.3 | 5.2 | 1.8e-07 | -0.01 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SMG6 | 0.03 | 0.01 | blup | 144 | 0.01 | 4.8e-03 | 6.4 | 5.2 | 2.5e-07 | -0.04 | 0.00 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SRR | 0.30 | 0.40 | lasso | 7 | 0.39 | 8.5e-47 | -4.9 | 5.2 | 2.3e-07 | -0.07 | 0.84 | 0.16 | FALSE |
| 7 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SRR | 0.16 | 0.03 | blup | 61 | 0.02 | 8.7e-02 | -4.9 | 5.7 | 1.3e-08 | -0.07 | 0.01 | 0.59 | FALSE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SGSM2 | 0.13 | 0.01 | blup | 81 | 0.01 | 1.1e-01 | 5.5 | -6.0 | 2.5e-09 | 0.08 | 0.01 | 0.66 | TRUE |