Hub : Genes

SMG6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0400	0.0190	1.7e-02	0.048	0.013	0.033	0.017	0.041	1.4e-06	8.4e-03	6.0e-05	3.0e-03	8.9e-06
2	GTEx	Brain Cerebellum	0.2370	0.0890	9.4e-03	0.027	NA	0.050	NA	0.050	5.5e-02	NA	1.3e-02	NA	1.4e-02
3	GTEx	Testis	0.2800	0.0790	1.3e-05	0.070	NA	0.137	NA	0.124	4.8e-04	NA	1.2e-06	NA	4.0e-06
4	ROSMAP	Brain Pre-frontal Cortex	0.1015	0.0293	1.1e-05	0.027	0.042	0.034	0.041	0.037	1.9e-04	4.0e-06	3.1e-05	4.7e-06	1.5e-05
5	TCGA	Breast Invasive Carcinoma	0.0267	0.0160	1.0e-03	0.008	0.009	0.009	NA	0.006	6.2e-03	4.8e-03	5.6e-03	NA	2.0e-02
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0780	0.0360	1.3e-04	0.050	0.065	0.051	NA	0.046	7.7e-04	1.3e-04	7.2e-04	NA	1.2e-03
7	TCGA	Prostate Adenocarcinoma	0.0388	0.0209	4.4e-03	0.008	0.017	0.010	NA	0.012	4.4e-02	5.5e-03	3.0e-02	NA	1.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.8	1.6	-1.3	0.4	0.7	-1.1	-0.9	-0.9	-0.6
Bipolar Disorder or Schizophrenia	1.8	4.4	14.2	-0.8	0.6	1.9	-0.0	-3.5	-3.8	0.4
Depressed Affect (Nagel 2018)	1.0	2.1	5.7	-1.5	-2.4	-1.8	0.4	1.4	0.8	-1.0
Depression (Nagel 2018)	1.8	2.7	8.1	-1.9	0.0	-1.2	-0.5	2.8	2.4	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	-0.5	-0.3	-0.8	0.6	-0.2	-0.3	0.0
Neuroticism (Nagel 2018)	3.0	6.9	13.7	-3.7	-3.7	-3.2	-0.6	1.3	0.7	-3.0
Schizophrenia (2018)	2.5	5.3	17.1	-0.0	0.4	1.8	0.9	-3.8	-4.1	1.0
Schizophrenia vs Biploar Disorder	2.1	2.7	8.3	0.5	-2.1	-0.3	1.1	-2.2	-2.9	0.3
Worry (Nagel 2018)	5.5	11.6	20.4	-4.3	-4.5	-4.1	-2.4	-0.2	-0.3	-4.5
Alzheimer’s Disease (in mother)	0.4	0.5	1.6	-0.7	0.4	-1.2	-0.6	0.4	0.8	-0.3
Alzheimer’s Disease (in father)	0.6	0.7	2.0	0.5	-1.1	-1.0	-1.4	0.1	0.4	-0.1
Alzheimer’s Disease (including proxy)	0.7	1.1	3.4	0.1	-1.3	-1.8	-1.3	-0.1	0.4	-0.8
Crohns Disease (2017)	0.6	1.3	3.7	-0.2	1.9	0.4	0.3	-1.2	-1.3	1.3
Irritable Bowel Disease (IBD)	1.0	2.3	10.6	-0.3	3.3	0.1	0.7	-1.1	-0.9	1.7
Ulcerative Colitis (UC)	0.8	1.5	8.0	-0.8	2.8	0.1	0.5	-0.5	-0.2	1.1
Major Depression (MDD)	0.8	1.0	3.0	1.1	0.7	-0.7	1.7	0.2	0.7	1.0
Reaction Time	1.3	2.4	5.0	-1.8	-0.2	1.5	-2.2	-1.9	-0.7	-1.6
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.2	-1.2	-1.3	-1.8	-0.5	-0.0	-0.0	-1.6
Breast Cancer	2.0	4.7	12.3	1.4	0.2	3.5	2.9	-1.7	-1.8	2.1
Ovarian Cancer	1.6	2.1	5.9	1.7	1.5	-0.4	2.4	-0.0	-0.3	1.8
Prostate Cancer	0.1	0.1	0.6	-0.0	-0.0	0.8	-0.2	-0.1	0.3	-0.4
Age at First Birth	0.7	1.1	3.6	0.8	-0.7	0.3	0.2	-1.9	-1.6	-0.0
Bipolar Disorder (2011)	0.4	0.4	1.2	0.0	0.0	0.0	0.0	-1.1	-0.5	-1.0
Body Mass Index (BMI) (2010)	2.2	3.0	8.9	0.3	0.9	-1.6	-0.8	2.8	3.0	-0.0
Coronary Artery Disease (CAD)	4.8	5.8	16.0	-1.2	0.5	-1.8	-1.3	3.8	4.0	-1.8
Crohns Disease (2012)	0.3	0.4	2.2	0.3	1.5	0.4	0.4	0.3	-0.0	0.6
Mean Putamen Volume	0.5	0.6	1.6	1.3	1.0	-0.3	-0.6	-0.9	-0.2	0.5
Fasting Glucose	1.0	1.2	4.9	0.0	0.4	-0.0	0.5	-2.2	-1.8	0.4
HbA1C	0.2	0.2	0.8	0.1	-0.2	0.1	-0.6	-0.9	-0.3	-0.1
HDL Cholesterol	0.8	1.4	4.0	0.1	-0.2	0.1	1.5	-1.6	-2.0	0.8
LDL Cholesterol	1.2	2.0	7.5	-0.8	-0.8	-0.6	0.5	-2.1	-2.7	-0.3
Lupus	0.3	0.5	1.5	0.0	0.5	1.0	0.1	-1.2	-1.0	-0.1
Neuroticism (2016)	1.0	1.5	3.2	-1.0	-1.7	-1.8	1.3	0.7	0.1	-1.0
Primary Biliary Cirrhosis	0.6	0.9	1.7	1.2	0.9	0.2	1.3	0.4	0.9	1.2
Rheumatoid Arthritis	0.5	0.7	1.7	-0.2	-0.6	-1.3	-0.7	1.2	0.7	-0.8
Schizophrenia (2014)	3.6	7.9	29.1	-0.9	-0.9	1.4	0.6	-4.7	-5.4	0.1
Triglycerides	0.8	1.2	2.6	-0.6	-1.0	-0.6	-1.6	-1.4	-1.0	-1.2
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.6	-1.9	-0.3	0.4	-1.7	-1.0	-0.3	-1.6
Ulcerative Colitis	1.5	2.2	10.8	-0.0	3.3	0.0	1.4	0.1	0.4	1.7
Blood Eosinophil Count	0.2	1.7	4.3	-1.2	-0.7	0.9	-1.8	-1.3	-0.4	-2.1
Blood Platelet Count	10.2	118.4	334.9	-5.4	-8.7	3.2	-4.5	-18.3	-18.3	-5.0
Blood Red Count	0.7	6.8	20.6	1.6	0.9	0.6	1.6	4.5	4.5	0.6
Blood White Count	5.6	41.4	125.4	-3.6	-1.0	5.0	-2.1	-11.2	-10.8	-1.9
Heel T-Score	17.3	137.8	400.0	1.1	11.8	1.9	3.0	20.0	19.3	6.2
BMI	2.7	15.8	25.8	-1.6	-1.7	-5.1	-4.2	4.9	4.8	-3.9
Height	0.6	12.5	32.0	0.5	3.3	4.1	5.7	0.6	0.8	5.2
Waist Hip Ratio (WHR)	1.5	6.9	18.0	-1.1	-1.2	-1.2	-2.0	3.6	4.2	-3.0
Systolic Blood Pressure	7.6	37.9	77.4	-7.7	-8.6	-3.8	-5.8	-1.4	-2.5	-8.8
Smoking Status	6.8	16.3	32.7	5.0	5.7	2.9	4.1	1.7	1.6	5.1
Allergy or Eczema	4.2	11.0	16.8	3.7	2.3	2.8	3.2	-3.3	-3.5	4.1
Cardiovascular Disease	2.1	6.8	10.9	-2.9	-1.4	-2.4	-2.0	3.3	2.8	-3.0
Hypothyroidism (self reported)	0.7	1.7	4.7	1.0	2.2	-0.8	0.9	1.3	0.9	1.5
Respiratory disease	1.7	3.8	11.8	1.5	1.2	-0.2	0.2	3.4	3.3	0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.7	0.2	0.2	-0.7	-0.5	0.2	-0.5
Lung FEV1/FVC ratio	5.3	26.9	89.9	-1.1	-2.9	1.3	-0.8	-9.2	-9.5	-0.7
Lung FVC	2.2	11.3	28.2	-4.5	-2.5	-1.9	-5.3	1.2	0.8	-4.2
Neuroticism	1.6	3.8	8.1	-2.6	-2.0	-2.8	-0.4	1.2	0.7	-2.4
Chronotype (morning person)	0.1	0.3	0.8	0.8	-0.5	0.2	0.9	0.5	0.2	0.5
Hair Pigment	0.0	1.1	3.9	1.1	0.6	0.4	0.4	1.3	2.0	-0.6
Tanning	0.3	3.2	9.3	-1.6	-3.0	-0.4	-2.3	-1.1	-1.5	-1.3
Hand grip strength (left)	1.3	3.3	5.1	-2.3	-1.8	-1.5	-1.3	2.0	1.6	-2.1
Number of treatments/medications taken	0.9	1.7	4.5	-0.3	-1.0	-1.0	-0.5	2.1	1.8	-1.2
Average weekly spirits intake	1.7	2.2	6.9	0.9	1.2	-0.1	0.4	2.6	2.0	1.4
Sensitivity / hurt feelings	0.4	0.7	2.4	-1.5	-0.6	-0.4	0.8	-0.1	-0.3	-0.9
Frequency of depressed mood in last 2 weeks	1.0	1.3	4.2	-0.6	0.2	-1.3	-0.6	2.0	1.7	0.1
Hearing difficulty/problems: Yes	1.1	1.6	8.4	0.0	-0.3	-1.4	2.9	0.8	0.4	0.4
Relative age of first facial hair	2.1	4.3	14.2	1.0	-0.4	0.7	0.2	-3.8	-3.8	0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.0	-0.3	-0.4	1.2	-1.4	-0.5	-0.2	-0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	0.8	0.0	0.3	0.5	-0.6	-0.5	0.5
Ever had hysterectomy (womb removed)	0.9	1.0	1.8	0.2	0.6	-1.1	1.0	1.3	1.3	0.9
Systolic blood pressure, automated reading	9.9	28.7	62.8	-6.7	-6.9	-3.8	-5.6	-0.2	-0.7	-7.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.1	-0.8	1.4	0.7	0.2	0.4	0.5	0.4
Angina	1.8	2.4	7.2	-0.9	-1.1	0.5	-0.5	2.2	2.7	-1.5
Medication for hormone replacement therapy	1.0	1.2	3.8	-0.9	-1.8	-0.4	-0.3	-0.2	-0.1	-2.0
Vitamin and mineral supplements	1.8	2.5	6.3	-0.9	0.3	-2.2	0.5	2.2	2.5	-0.6
Supplements: Zinc	2.4	2.6	4.2	1.9	1.2	2.1	1.4	-1.2	-1.1	2.0
Medication: Co-codamol	2.0	2.3	5.2	2.3	2.1	0.7	1.4	-0.6	-0.6	1.7
Medication: Metformin	0.7	1.0	1.7	1.1	-1.3	0.3	-0.8	-1.3	-0.8	-0.8
Diabetes (father)	1.8	2.3	7.9	0.5	-1.0	0.9	0.1	-2.8	-2.4	-0.5
Diabetes (mother)	1.5	2.0	6.7	-1.5	-0.9	-0.8	-2.6	-0.8	-0.7	-1.5
Severe depression (siblings)	0.9	1.0	2.1	1.4	1.4	0.5	0.9	0.2	0.3	1.3
Pack years adult smoking proportion	2.2	3.3	10.3	1.1	-1.3	-0.8	-0.8	-3.2	-3.0	-0.1
Impedance of leg (right)	5.7	27.7	62.6	0.8	0.2	6.3	4.6	-7.7	-7.9	3.2
Leg fat-free mass (left)	2.3	12.1	35.4	-0.2	1.1	-3.7	-1.4	6.0	5.7	-0.2
Trunk fat percentage	1.1	4.3	9.0	-1.7	-2.4	-2.7	-1.9	1.0	0.5	-3.0
Hand grip strength (right)	0.6	1.6	4.9	-2.2	-1.7	-0.3	-0.3	0.7	0.6	-1.7
Townsend deprivation index at recruitment	0.8	1.1	2.3	1.1	0.4	0.4	0.6	-1.5	-1.2	1.4
Current tobacco smoking	4.2	6.9	13.9	3.2	3.2	1.8	2.2	-1.5	-1.8	3.7
Average weekly fortified wine intake	2.9	3.4	8.4	1.2	2.9	1.8	1.4	1.2	0.9	2.5
Maternal smoking around birth	2.9	4.2	10.9	2.5	3.3	1.7	1.8	0.6	0.2	2.3
Fed-up feelings	0.6	1.0	2.7	1.4	0.2	-0.3	1.5	0.4	0.1	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	4.9	-0.7	0.6	-1.2	-0.5	2.2	1.8	0.2
Relative age voice broke	1.6	2.4	5.3	2.3	1.2	1.1	0.4	-1.9	-1.7	1.5
Taking other prescription medications	1.7	2.6	8.2	1.3	0.6	-0.6	0.9	2.7	2.9	0.1
Age when periods started (menarche)	1.8	4.4	9.7	1.6	0.5	3.1	1.8	-2.3	-2.6	1.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.3	0.5	0.0	0.5	0.1	0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	12.9	29.3	82.7	2.0	5.5	0.6	2.9	9.1	8.3	3.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.1	1.0	0.9	0.3	-0.1	-0.4	-0.2	0.6
Qualifications: CSEs or equivalent	0.6	0.8	1.3	1.2	0.6	1.1	1.0	-1.0	-0.7	0.6
Serious illness, injury or assault to yourself	0.8	1.0	2.1	-0.5	-0.2	-0.8	-1.2	1.1	1.4	-1.2
High blood pressure	4.1	11.5	21.2	-2.3	-2.0	-3.3	-2.8	4.6	4.3	-3.6
Hayfever, allergic rhinitis or eczema	2.9	6.3	8.7	2.5	1.7	2.6	2.7	-2.6	-2.4	3.0
Multivitamins +/- minerals	0.8	1.0	3.5	0.4	-0.3	1.9	-0.6	-1.0	-1.4	0.3
Stomach or abdominal pain in last month	1.3	1.6	4.4	-0.2	1.3	0.6	0.2	2.1	2.0	0.9
Supplements: Glucosamine	1.4	1.9	4.0	-1.0	-0.7	0.0	-1.6	1.7	2.0	-1.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.3	0.8	1.5	0.1	0.5	0.7	0.5	1.1
Medication: Atenolol	2.6	3.2	9.7	-0.7	0.5	-1.9	0.0	2.8	3.1	-1.0
Medication: Levothyroxine sodium	0.5	0.8	1.7	-1.1	0.2	-1.3	-0.4	1.1	0.9	-0.6
Sitting height	0.3	1.8	8.2	-2.9	-1.7	0.1	-0.7	-0.4	-0.8	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.1	-0.7	-0.4	-0.7	0.4	0.1	-0.5
High blood pressure (mother)	0.2	0.3	0.9	0.1	-1.0	0.4	-0.7	-0.3	-0.2	-0.8
Body mass index (BMI)	2.7	11.4	26.6	-0.5	-0.5	-4.4	-2.3	5.2	4.8	-2.2
Impedance of leg (left)	6.2	30.2	68.6	1.0	0.2	6.8	4.4	-8.1	-8.3	3.3
Leg predicted mass (left)	2.3	12.2	35.2	-0.2	1.1	-3.8	-1.4	5.9	5.7	-0.2
Trunk fat mass	0.9	3.8	6.9	-1.1	-1.3	-2.6	-1.3	2.6	2.1	-1.9
Waist circumference	2.3	8.3	21.4	-0.6	-0.6	-3.2	-1.5	4.6	4.5	-1.9
Number of incorrect matches in round	0.8	1.3	2.9	-0.5	-1.0	1.7	-1.3	-1.1	-1.3	-0.3
Past tobacco smoking	3.0	5.5	9.2	-2.3	-3.0	-2.8	-2.1	-1.4	-1.8	-2.6
Alcohol usually taken with meals	0.9	1.4	4.5	-0.5	1.3	0.1	0.7	1.3	2.1	1.1
Nervous feelings	7.7	14.3	26.7	-5.1	-4.3	-3.7	-3.9	-0.4	-0.8	-5.2
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	5.4	-1.5	-0.7	-2.2	-1.1	2.3	1.8	-0.8
Hearing difficulty/problems with background noise	1.6	2.5	13.4	0.3	1.1	-0.5	3.7	0.8	0.5	1.4
Hair/balding pattern: Pattern 2	3.2	4.1	12.5	-0.6	-0.6	0.6	1.5	-3.4	-3.5	1.1
Had menopause	1.1	1.4	3.5	-1.1	-0.8	-1.9	-1.3	-1.2	-0.8	-0.9
Had other major operations	1.7	2.1	3.4	0.2	1.7	1.8	0.3	1.8	1.7	1.5
Forced vital capacity (FVC)	0.8	3.1	8.9	-3.0	-0.2	-0.5	-2.2	1.8	1.5	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	10.0	22.9	68.1	1.6	4.3	0.5	2.8	8.3	7.5	2.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	-1.4	0.4	-0.7	-1.0	-0.7	-0.4	-0.9
Qualifications: None of the above	0.6	1.4	3.3	-1.1	-1.6	-0.8	-1.8	0.1	-0.3	-1.3
Financial difficulties in last 2 years	0.4	0.5	1.6	-1.3	-0.0	-0.0	-0.1	-0.2	-1.2	-0.6
Mouth/teeth dental problems	0.4	0.6	2.4	-0.3	-0.0	0.1	1.5	-0.4	-1.1	0.7
Heart attack	2.6	3.3	11.4	-0.7	-0.3	-0.3	-0.3	3.4	3.3	-0.2
Allergy	1.9	4.4	8.2	-2.1	-2.4	-2.3	-2.6	0.5	0.3	-2.9
Pain all over the body in last month	0.4	0.5	1.7	-0.9	-0.2	-0.2	-0.8	-0.0	-0.3	-1.3
Diabetes (self-reported)	1.1	1.7	4.8	-0.3	-1.6	-0.9	-1.5	0.4	1.2	-2.2
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	3.5	1.6	1.7	0.9	1.9	-1.2	-0.5	1.4
Medication: Ramipril	1.9	2.4	6.5	-1.2	-0.2	0.7	-1.7	2.1	2.5	-1.1
Medication: Simvastatin	1.2	1.7	6.4	-0.1	0.8	-0.9	0.6	2.5	1.9	-0.1
Fluid intelligence score	0.5	0.9	2.5	-0.2	-0.8	-1.5	1.6	0.9	0.5	-0.3
Illnesses of siblings	3.3	4.6	16.0	0.3	0.4	0.6	0.7	-4.0	-3.8	0.7
Neuroticism score	1.7	3.5	6.6	-2.6	-2.0	-2.2	-1.1	1.3	0.9	-2.2
Weight	1.7	8.3	26.4	0.0	0.6	-2.9	-0.8	5.1	4.7	-0.2
Impedance of arm (right)	3.7	17.1	37.7	-2.9	-4.8	0.6	-1.1	-6.1	-6.0	-3.5
Arm fat percentage (right)	2.8	11.0	21.0	-1.8	-3.0	-4.6	-2.9	3.2	2.8	-4.2
Trunk fat-free mass	2.6	14.9	39.4	1.6	3.8	-0.9	1.4	6.3	6.0	3.1
Hip circumference	0.7	3.1	9.0	-0.3	-0.7	-3.0	-0.7	2.6	2.1	-0.6
Time employed in main current job	0.3	0.4	0.8	0.5	0.5	0.4	-0.6	0.9	0.9	0.3
Alcohol intake versus 10 years previously	0.9	1.4	4.7	-1.1	-0.9	-0.2	-2.2	-0.4	0.4	-1.6
Father’s age at death	2.2	2.9	5.8	2.0	0.9	0.1	1.4	-2.4	-2.1	1.8
Worrier / anxious feelings	1.7	3.3	10.0	-3.2	-2.0	-1.6	-1.0	-0.4	-0.5	-2.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.8	0.2	1.4	-1.2	1.1	1.3	0.6	1.1
Falls in the last year	0.1	0.2	0.7	-0.4	0.1	-0.1	0.2	0.7	0.9	-0.1
Hair/balding pattern: Pattern 3	0.8	1.2	3.6	-1.4	0.2	0.8	0.4	1.9	1.3	-0.5
Number of live births	0.7	1.0	3.1	1.0	0.7	0.1	0.5	1.8	1.3	0.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	9.9	-3.1	-0.8	-0.4	-2.2	-0.5	-1.0	-1.4
Pulse rate	0.3	0.4	2.0	-1.4	0.6	0.8	0.2	0.2	0.2	-0.1
Happiness	1.2	1.4	3.1	0.5	-0.4	1.3	1.8	-1.4	-1.7	0.6
Noisy workplace	0.3	0.3	1.2	-0.6	-0.4	-0.2	-0.5	0.2	0.4	-1.1
Qualifications: A levels/AS levels or equivalent	1.4	3.1	8.4	0.7	0.6	1.7	1.6	-2.9	-2.3	1.6
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	6.4	1.4	2.5	2.0	1.2	0.6	1.1	1.7
Mouth/teeth dental problems: Dentures	0.6	1.1	2.4	-0.9	-0.6	0.5	-1.6	1.0	1.0	-1.3
Asthma	1.3	2.6	8.1	1.0	1.4	0.2	0.4	2.8	2.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	7.7	-0.1	-0.3	0.7	-1.7	-2.7	-2.8	-0.6
Medication: Cholesterol lowering	1.0	1.6	5.4	0.3	0.1	0.4	1.0	2.3	2.1	0.2
Depression (self-reported)	0.9	1.1	2.7	1.0	1.4	-0.2	-0.5	0.8	1.6	1.0
Medication: Lansoprazole	2.0	2.3	6.8	-0.9	1.1	0.9	-0.9	2.6	2.3	-0.1
Prospective memory result	0.9	1.1	3.3	-0.4	-0.7	-1.0	-1.8	-0.9	-0.9	-1.0
Lung cancer (father)	0.4	0.5	2.0	0.8	0.2	1.4	-0.0	-0.2	-0.4	0.8
Illnesses of mother	0.2	0.2	0.7	-0.2	-0.1	-0.2	0.3	-0.4	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	13.2	-3.6	-0.8	-0.0	-2.3	-0.7	-1.0	-1.8
Pulse wave Arterial Stiffness index	0.7	0.8	2.4	-1.0	0.0	0.9	-0.4	-1.1	-1.6	-0.2
Impedance of arm (left)	3.5	16.3	43.1	-2.4	-3.6	1.5	-0.5	-6.6	-6.5	-2.6
Arm fat mass (right)	2.2	9.0	16.8	-1.3	-1.3	-4.0	-2.4	4.1	3.7	-2.8
Trunk predicted mass	2.6	14.7	39.6	1.5	3.7	-0.9	1.4	6.3	6.0	3.0
Standing height	0.6	5.8	16.0	1.0	2.5	2.7	3.0	0.8	0.8	4.0
Length of working week for main job	2.8	3.1	11.1	-1.0	0.3	-0.9	-0.6	3.3	2.9	-0.5
Exposure to tobacco smoke at home	1.5	1.7	4.0	-0.4	-0.6	-1.6	-0.2	1.8	2.0	-1.1
Breastfed as a baby	1.1	1.4	2.6	-0.8	-1.4	0.3	-1.6	0.9	1.3	-1.4
Tense / ‘highly strung’	1.6	2.6	8.4	-2.9	-1.1	-2.3	-1.0	0.7	0.4	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.1	6.4	0.9	1.2	-0.8	0.8	1.7	2.5	1.2
Hair/balding pattern: Pattern 4	6.3	15.2	28.0	-3.1	-5.0	-5.3	-4.4	-0.6	-1.1	-4.7
Birth weight of first child	2.0	3.7	9.9	-0.6	-2.3	0.2	-1.0	-3.1	-2.6	-1.5
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.5	-0.6	-0.3	-0.4	-0.1	-0.5	-0.1
Pulse wave reflection index	1.0	1.3	3.9	0.3	-0.1	0.6	1.1	-1.6	-2.0	0.9
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	-0.1	0.7	-0.7	0.6	0.2	-0.1	0.9
Loud music exposure frequency	0.8	0.9	2.4	-1.4	-0.3	0.2	0.2	-1.1	-1.6	-0.7
Qualifications: O levels/GCSEs or equivalent	2.9	4.6	13.6	2.7	1.6	1.0	3.7	-0.8	-0.8	2.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	-0.8	0.6	-0.8	-0.9	0.2	0.9	-0.3
Blood clot in the leg (DVT)	2.6	3.3	12.1	0.7	3.5	1.7	0.6	1.0	2.0	1.7
Medication: Paracetamol	1.5	2.4	6.7	0.6	0.2	1.5	1.5	-2.6	-2.2	0.5
Headache pain in last month	2.1	3.6	10.1	-1.7	-1.1	0.6	-1.2	-3.2	-3.1	-0.6
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	9.4	1.1	0.2	1.2	0.1	-3.1	-2.6	0.9
Glaucoma (self-reported)	3.7	4.4	11.3	-0.5	0.3	2.4	1.6	-3.4	-3.0	1.3
Gout (self-reported)	1.6	2.3	3.8	-1.2	-1.9	-0.7	-2.0	1.1	1.1	-2.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.0	0.0	1.3	-0.9	0.1	1.4	0.8	0.7
Medication: Amlodipine	1.8	2.5	8.5	0.3	0.4	-1.8	-0.4	2.9	2.3	0.0
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.5	-0.6	0.3	1.1	0.5	1.9	1.5	-0.2
Birth weight	4.6	9.9	21.0	-2.8	-4.6	-3.0	-3.7	0.6	0.4	-4.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.4	0.8	2.3	0.3	1.1	1.1	0.9	1.1
High blood pressure (siblings)	4.1	5.8	19.5	-0.2	-0.1	-0.9	-1.2	4.4	4.3	-0.9
Forced vital capacity (FVC), Best measure	0.8	2.9	11.8	-3.4	-0.2	0.0	-1.8	1.2	1.0	-1.6
Body fat percentage	0.9	3.6	7.1	-1.4	-2.1	-2.6	-1.6	1.3	0.8	-2.7
Leg fat percentage (right)	0.1	0.5	1.6	0.1	-0.7	-1.0	0.2	1.2	0.6	-0.5
Arm fat-free mass (right)	2.4	12.4	28.7	1.7	4.2	-0.6	1.1	5.4	5.2	3.1
Exposure to tobacco smoke outside home	2.2	3.0	8.3	-1.3	-2.9	-1.5	-1.9	-0.2	-0.9	-2.0
Comparative body size at age 10	7.7	21.2	38.8	-3.6	-3.9	-6.2	-5.0	4.2	4.0	-4.8
Number of full brothers	1.8	2.2	6.0	-1.2	-1.5	1.2	-0.5	-1.9	-2.4	-0.6
Worry too long after embarrassment	1.4	2.4	6.5	-2.1	-0.8	-2.5	0.2	1.6	0.6	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.1	-1.2	-0.8	-0.4	0.1	0.4	-0.9
Wheeze or whistling in the chest in last year	1.6	2.8	8.0	0.6	1.8	-0.3	0.8	2.8	2.4	1.2
Number of children fathered	0.4	0.4	0.9	0.8	-0.9	0.1	-0.0	0.8	0.7	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	4.1	-2.0	-0.5	-0.0	0.2	-1.0	-0.9	-0.9
Age at first live birth	0.1	0.2	0.4	-0.7	0.7	0.5	0.4	0.1	0.3	0.3
Pulse wave peak to peak time	0.7	0.9	2.2	1.2	0.4	-0.3	0.9	1.0	1.5	0.7
Health satisfaction	1.5	1.9	4.9	-0.9	-0.4	-0.6	-0.4	2.0	2.2	-1.7
Shortness of breath walking on level ground	2.0	2.4	7.0	0.9	1.1	-0.8	0.9	2.4	2.6	0.6
Qualifications: College or University degree	0.6	1.9	7.9	-0.5	-0.5	0.2	-1.1	-2.8	-1.8	-0.2
Eye problems/disorders: None of the above	1.3	1.5	3.8	-0.6	-1.5	-1.9	-0.4	1.1	0.6	-1.7
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.1	1.5	0.8	-1.1	-0.2	-0.4	0.8	-0.1
Emphysema/chronic bronchitis	1.1	1.3	2.8	1.3	0.6	-1.6	0.0	0.8	1.7	-1.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.7	0.6	0.2	-1.0	0.1	1.3	1.3	0.5
Neck or shoulder pain in last month	0.4	0.6	1.5	-1.2	0.5	0.3	-0.3	1.1	1.0	-0.2
Medication: Blood pressure	1.7	3.0	7.8	-1.4	-0.8	-1.6	-0.8	2.8	2.4	-1.5
Angina (self-reported)	1.7	2.2	7.3	-0.5	-0.8	0.5	-0.3	2.3	2.7	-1.1
Migraine (self-reported)	1.6	1.9	5.4	-0.2	-1.7	0.8	-0.7	-2.3	-1.9	-0.7
Medication: Ibuprofen	1.4	1.7	5.2	0.3	-0.5	0.4	-1.3	-2.0	-2.3	-0.5
Medication: Allopurinol	0.5	0.7	1.2	-0.6	-1.1	-0.6	-0.9	1.0	0.7	-0.8
Medication: Omeprazole	1.4	1.7	3.6	1.5	1.3	1.4	1.9	-0.4	0.1	1.3
Medication: Seretide 50 evohaler	0.6	0.7	1.9	-0.2	0.9	1.4	0.8	0.6	0.9	0.8
Mean time to correctly identify matches	1.0	1.9	4.1	-1.5	-0.4	1.5	-2.0	-1.4	-0.2	-1.6
Heart disease (mother)	1.4	1.7	4.0	0.4	0.0	0.6	1.8	2.0	2.0	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	0.7	0.1	-0.5	1.3	1.2	0.9	-0.1
Whole body fat mass	1.0	4.4	8.7	-1.0	-1.1	-2.9	-1.4	2.9	2.5	-1.9
Leg fat mass (right)	0.8	3.2	9.7	-0.2	-0.3	-2.2	-0.5	3.1	2.6	-0.7
Arm predicted mass (right)	2.2	11.5	27.0	1.6	4.0	-0.9	1.1	5.2	5.0	2.9
Pulse rate, automated reading	0.1	0.5	1.0	-0.9	1.0	-0.3	-0.3	0.9	0.6	-0.4
Alcohol intake frequency.	0.8	1.8	3.7	-1.1	-0.5	0.2	-1.9	-1.9	-1.4	-1.3
Comparative height size at age 10	0.3	1.5	5.5	-0.5	0.9	0.5	0.6	1.5	2.4	1.0
Number of full sisters	0.6	0.8	1.8	-0.4	1.3	1.3	1.1	0.0	-0.0	0.7
Suffer from ‘nerves’	6.9	10.8	22.5	-3.9	-4.7	-2.3	-3.2	-0.2	-0.2	-4.7
Overall health rating	0.6	1.3	3.0	-1.7	0.5	-0.9	-0.6	1.5	1.0	-1.2
Chest pain or discomfort	0.5	0.7	1.9	0.1	0.4	-0.9	0.8	1.0	1.4	-0.6
Had major operations	3.7	4.3	10.2	-1.6	-2.1	-1.6	-1.4	1.7	2.4	-3.2
Age at last live birth	0.9	1.3	3.6	0.4	1.9	1.6	0.6	-0.3	-0.2	1.4
Family relationship satisfaction	1.1	1.3	3.9	-0.0	0.3	0.8	0.9	-2.0	-1.9	-0.1
Leg pain on walking	1.7	2.1	5.5	-1.6	-1.6	-0.2	-2.4	-0.4	-1.0	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.9	-1.0	-0.6	0.4	-1.3	-1.3	-1.0	-1.7
Commuting to job workplace: Car/motor vehicle	1.4	1.6	6.8	0.2	-2.6	-0.3	-0.8	0.8	0.8	-1.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.5	0.5	-0.7	-1.2	0.9	0.5	0.3	0.6
Medication: Aspirin	2.8	3.7	6.1	-1.6	-1.7	-1.5	-2.2	2.0	1.8	-2.5
Supplements: Vitamin C	1.0	1.2	4.0	0.4	0.6	2.0	-0.3	-1.3	-1.4	0.6
Knee pain experienced in last month	2.4	3.8	9.1	-1.7	-1.1	-1.4	-3.0	2.0	1.6	-2.2
Hypertension (Self-reported)	3.9	10.8	21.0	-2.2	-2.0	-3.5	-2.3	4.6	4.1	-3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.6	-1.2	0.5	0.6	0.3	-0.6	-0.7	-0.1
Illnesses of father: Heart disease	5.0	7.0	27.4	-1.4	2.0	-0.1	0.7	3.8	5.2	-0.7
Illnesses of siblings: Diabetes	0.1	0.1	0.4	0.6	0.0	0.4	0.0	-0.3	-0.1	0.1
Smoking status: Previous	1.8	2.6	5.7	1.3	1.7	1.7	1.1	1.8	2.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.0	-0.4	0.8	1.7	0.8	-0.7	-1.3	1.7
Whole body fat-free mass	2.3	13.3	39.1	1.0	3.0	-2.0	0.3	6.2	6.0	1.9
Leg fat-free mass (right)	2.2	11.7	33.9	0.0	1.2	-3.6	-1.5	5.8	5.6	-0.0
Arm fat percentage (left)	2.4	9.4	17.7	-1.7	-2.5	-4.2	-2.8	3.0	2.5	-4.0
Average weekly red wine intake	0.5	0.8	2.1	-1.5	-0.6	-1.1	0.4	0.7	0.9	-0.6
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	-0.8	0.3	-0.0	-0.5	-0.9	-0.2	-0.7
Mood swings	1.1	2.0	7.0	-2.0	-2.6	-0.9	-0.4	0.2	0.2	-1.4
Loneliness, isolation	0.6	0.9	3.3	-1.0	-1.8	0.1	-0.7	-0.4	-0.5	-1.0
Long-standing illness, disability or infirmity	0.9	1.4	4.3	0.5	-0.4	-0.2	-0.8	2.1	2.0	-0.3
Ever had bowel cancer screening	2.9	3.4	10.6	0.3	0.7	-1.4	0.6	3.2	3.3	-0.0
Diabetes diagnosed by doctor	0.7	1.2	3.9	-0.3	-0.8	-0.2	-2.0	-0.8	-0.1	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.3	-0.2	1.3	0.0	1.0	1.5	1.5	0.5
Friendships satisfaction	0.5	0.7	1.7	-1.3	-0.8	0.4	0.4	-0.9	-1.0	-0.4
Qualifications: nursing, teaching	1.0	1.6	3.1	-0.0	1.3	1.3	0.9	-1.8	-1.5	1.1
Commuting to job workplace: Walk	1.6	1.7	5.9	0.0	0.1	0.0	-0.2	-2.4	-2.4	0.5
Eye problems/disorders: Cataract	0.4	0.5	1.6	-0.3	1.3	-0.4	-0.6	0.9	0.7	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.2	1.0	-0.5	-1.1	-0.2	-0.6	-0.2	-0.0
Medication for cholesterol	2.2	3.3	8.8	1.0	0.9	1.4	0.3	-3.0	-2.8	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	6.4	0.4	0.4	-0.0	-0.2	2.5	2.1	0.6
Back pain experienced in last month	1.3	2.0	5.5	2.3	1.8	1.7	0.7	-0.3	0.2	1.2
Mineral and other dietary supplements	0.6	0.8	1.7	0.1	1.3	-0.1	1.2	0.9	1.2	0.4
Breast cancer (self-reported)	0.7	0.8	2.1	-0.1	-0.8	-1.4	-0.9	0.0	0.6	-1.4
Asthma (self-reported)	0.9	1.8	5.4	1.0	1.3	0.7	0.3	2.3	2.0	0.4
Osteoporosis (self-reported)	1.4	1.8	2.7	-0.6	-1.6	-1.0	-1.6	-1.2	-1.4	-1.6
Osteoarthritis (self-reported)	3.1	4.0	7.5	2.0	2.7	1.8	1.5	1.2	2.1	2.3
Medication: Aspirin	3.1	4.0	5.7	-1.6	-1.3	-1.9	-1.8	2.4	2.3	-2.4
Medication: Gliclazide	2.8	3.1	8.7	-0.4	-3.0	-0.8	-2.7	0.7	0.5	-2.1
Illnesses of father: None of the above (group 1)	1.2	1.5	5.9	0.9	-0.2	0.5	0.3	-1.7	-2.4	0.7
Smoking status: Current	5.6	9.0	19.1	3.4	3.9	2.3	2.7	-1.3	-1.6	4.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.4	7.2	16.1	-4.0	-2.4	-1.9	-3.1	0.6	0.6	-3.9
Whole body water mass	2.3	12.9	37.9	1.0	3.0	-2.0	0.2	6.2	5.9	1.9
Leg predicted mass (right)	2.2	11.8	34.0	-0.1	1.2	-3.6	-1.6	5.8	5.6	-0.2
Arm fat mass (left)	1.9	7.6	15.7	-0.9	-0.9	-3.6	-2.0	4.0	3.6	-2.4
Number of self-reported non-cancer illnesses	1.4	2.4	9.1	0.1	1.4	-0.1	0.7	2.4	3.0	-0.2
Average weekly champagne plus white wine intake	0.8	1.1	4.0	-0.1	0.3	0.0	0.6	2.0	1.8	0.5
Miserableness	0.5	0.8	3.5	-0.2	-0.8	-1.9	0.8	0.8	0.4	-0.2
Guilty feelings	2.1	3.2	7.5	-0.5	0.1	-2.7	1.5	2.7	2.2	-0.6
Wears glasses or contact lenses	0.6	0.7	1.9	-1.4	-1.2	-0.2	0.3	0.7	0.5	-0.7
Ever taken oral contraceptive pill	1.6	1.8	4.3	-2.1	-1.2	1.0	-1.1	-1.5	-1.2	-1.1
Hearing aid user	0.5	0.5	1.6	1.0	-0.9	-0.3	1.3	-0.0	-0.1	0.5
Mother’s age at death	1.5	1.8	4.5	0.0	-1.1	0.7	-1.5	-2.1	-2.0	0.5
Financial situation satisfaction	0.6	0.8	2.7	-0.3	1.5	1.6	0.4	-0.0	-0.3	0.4
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.3	-0.6	0.2	-0.5	0.3	1.2	0.4	0.8
Commuting to job workplace: Public transport	1.0	1.1	2.0	0.7	1.4	0.3	1.1	-1.3	-0.9	1.4
Eye problems/disorders: Glaucoma	2.4	2.8	5.5	0.1	0.7	2.3	1.6	-2.2	-1.9	1.7
Medication: Blood pressure	2.4	4.5	12.7	-1.3	0.2	-1.6	-0.9	3.4	3.6	-1.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-0.0	0.8	0.3	-0.1	-1.1	-0.8	-0.2
Supplements: Fish oil (including cod liver oil)	1.0	1.2	2.4	-1.1	-1.2	-0.1	-1.1	-1.3	-1.5	-0.8
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.4	0.4	0.4	0.7	-0.2	-0.2	0.2
Medication: Bendroflumethiazide	1.0	1.5	4.2	-0.7	-1.2	-0.6	-0.9	2.0	1.3	-1.3
Medication: Paracetamol	0.6	0.9	2.7	-0.6	0.0	0.8	0.7	-1.7	-1.5	-0.2
Medication: Lisinopril	1.1	1.4	2.7	-0.4	1.3	-1.3	1.5	1.6	1.2	0.4
Medication: Atorvastatin	0.4	0.5	1.2	0.6	-0.8	0.5	-0.1	-1.1	-1.0	0.1
Illnesses of father: High blood pressure	0.8	1.0	2.2	-0.9	-1.0	-1.0	0.4	0.9	1.0	-1.5
Alcohol drinker status: Never	1.0	1.1	3.3	-1.1	-0.6	-0.5	-1.8	-1.0	-1.0	-1.0
Ever smoked	3.4	5.9	10.9	2.6	3.0	3.3	2.0	0.6	0.9	3.1
Basal metabolic rate	2.1	11.4	34.8	0.8	2.4	-2.3	0.1	5.9	5.6	1.4
Leg fat percentage (left)	0.2	0.7	2.2	0.2	-0.7	-1.0	-0.1	1.5	0.8	-0.6
Arm fat-free mass (left)	2.2	10.9	30.2	1.3	3.1	-1.5	0.7	5.5	5.2	2.3
Number of operations (self-reported)	1.5	2.3	9.1	-0.1	-0.2	-0.2	-0.9	2.3	3.0	-0.9
Average weekly beer plus cider intake	0.4	0.6	2.1	0.3	-0.2	-1.3	-1.5	0.7	0.2	-0.4
Irritability	0.5	0.8	2.6	1.4	0.6	0.6	0.4	0.3	0.7	1.6
Risk taking	1.3	1.9	5.0	-0.9	0.7	2.2	-0.9	-1.8	-1.5	0.7
Ever had prostate specific antigen (PSA) test	2.6	3.0	11.3	-0.6	-0.0	-1.3	0.6	3.4	2.6	0.2
Fractured/broken bones in last 5 years	0.4	0.5	1.3	-0.9	-0.1	-1.1	-0.6	-0.5	-0.6	-0.8
Age started oral contraceptive pill	0.9	1.2	3.5	-0.8	-1.1	-0.1	-0.3	-1.9	-1.6	-0.3
Diastolic blood pressure, automated reading	6.1	19.1	39.3	-4.8	-4.9	-4.0	-4.7	2.2	2.0	-6.3
Ever depressed for a whole week	0.2	0.2	0.6	-0.4	0.7	-0.8	-0.0	0.1	0.3	0.1
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.8	0.1	0.3	0.2	0.8	0.2	0.3
Commuting to job workplace: Cycle	0.9	1.1	2.4	1.6	1.0	0.7	0.8	0.8	1.2	1.0
Myopia	0.6	0.9	2.7	1.6	0.8	-0.5	1.0	0.4	0.4	1.1
Vascular/heart problems diagnosed by doctor	4.8	13.2	24.5	2.7	2.1	3.0	3.2	-5.0	-4.7	3.7
Cholesterol lowering medication	0.4	0.6	2.3	-0.7	-0.1	-0.3	0.2	1.5	1.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	7.6	1.7	2.0	1.5	2.8	-0.3	0.0	2.3
Pain experienced in last month	0.1	0.2	0.7	0.4	-0.4	0.2	0.8	-0.2	-0.3	0.4
Supplements: Calcium	0.9	1.0	1.5	0.9	0.5	1.2	-1.1	-1.2	-1.2	0.1
Basal cell carcinoma (self-reported)	3.0	3.6	9.1	-0.4	3.0	2.7	1.0	-0.7	-0.9	2.4
Heart attack/myocardial infarction (self-reported)	2.4	3.1	11.0	-0.6	-0.3	-0.5	-0.4	3.3	3.2	-0.3
Deep venous thrombosis (DVT) (self-reported)	3.0	3.9	13.2	1.0	3.6	1.7	0.7	1.3	2.1	1.8
Heart disease (siblings)	1.3	1.6	5.4	-0.9	0.3	-0.1	-0.3	1.9	2.3	-1.1
Alcohol drinker status: Previous	0.3	0.4	0.6	-0.7	-0.1	-0.7	-0.6	0.6	0.6	-0.8
Pack years of smoking	2.1	3.1	9.5	1.2	-1.5	-0.5	-0.7	-3.1	-2.8	-0.2
Impedance of whole body	4.5	23.0	67.1	-1.1	-2.4	4.2	1.8	-8.2	-8.2	-0.2
Leg fat mass (left)	0.9	3.5	10.6	-0.2	-0.3	-2.3	-0.6	3.3	2.7	-0.7
Arm predicted mass (left)	2.0	10.2	27.0	1.2	3.2	-1.2	0.7	5.2	5.0	2.3