Hub : Genes

SMG6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0400 0.0190 1.7e-02 0.048 0.013 0.033 0.017 0.041 1.4e-06 8.4e-03 6.0e-05 3.0e-03 8.9e-06
2 GTEx Brain Cerebellum 0.2370 0.0890 9.4e-03 0.027 NA 0.050 NA 0.050 5.5e-02 NA 1.3e-02 NA 1.4e-02
3 GTEx Testis 0.2800 0.0790 1.3e-05 0.070 NA 0.137 NA 0.124 4.8e-04 NA 1.2e-06 NA 4.0e-06
4 ROSMAP Brain Pre-frontal Cortex 0.1015 0.0293 1.1e-05 0.027 0.042 0.034 0.041 0.037 1.9e-04 4.0e-06 3.1e-05 4.7e-06 1.5e-05
5 TCGA Breast Invasive Carcinoma 0.0267 0.0160 1.0e-03 0.008 0.009 0.009 NA 0.006 6.2e-03 4.8e-03 5.6e-03 NA 2.0e-02
6 TCGA Kidney Renal Papillary Cell Carcinoma 0.0780 0.0360 1.3e-04 0.050 0.065 0.051 NA 0.046 7.7e-04 1.3e-04 7.2e-04 NA 1.2e-03
7 TCGA Prostate Adenocarcinoma 0.0388 0.0209 4.4e-03 0.008 0.017 0.010 NA 0.012 4.4e-02 5.5e-03 3.0e-02 NA 1.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.5 0.8 1.6 -1.3 0.4 0.7 -1.1 -0.9 -0.9 -0.6
Bipolar Disorder or Schizophrenia 1.8 4.4 14.2 -0.8 0.6 1.9 -0.0 -3.5 -3.8 0.4
Depressed Affect (Nagel 2018) 1.0 2.1 5.7 -1.5 -2.4 -1.8 0.4 1.4 0.8 -1.0
Depression (Nagel 2018) 1.8 2.7 8.1 -1.9 0.0 -1.2 -0.5 2.8 2.4 -0.4
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.7 -0.5 -0.3 -0.8 0.6 -0.2 -0.3 0.0
Neuroticism (Nagel 2018) 3.0 6.9 13.7 -3.7 -3.7 -3.2 -0.6 1.3 0.7 -3.0
Schizophrenia (2018) 2.5 5.3 17.1 -0.0 0.4 1.8 0.9 -3.8 -4.1 1.0
Schizophrenia vs Biploar Disorder 2.1 2.7 8.3 0.5 -2.1 -0.3 1.1 -2.2 -2.9 0.3
Worry (Nagel 2018) 5.5 11.6 20.4 -4.3 -4.5 -4.1 -2.4 -0.2 -0.3 -4.5
Alzheimer’s Disease (in mother) 0.4 0.5 1.6 -0.7 0.4 -1.2 -0.6 0.4 0.8 -0.3
Alzheimer’s Disease (in father) 0.6 0.7 2.0 0.5 -1.1 -1.0 -1.4 0.1 0.4 -0.1
Alzheimer’s Disease (including proxy) 0.7 1.1 3.4 0.1 -1.3 -1.8 -1.3 -0.1 0.4 -0.8
Crohns Disease (2017) 0.6 1.3 3.7 -0.2 1.9 0.4 0.3 -1.2 -1.3 1.3
Irritable Bowel Disease (IBD) 1.0 2.3 10.6 -0.3 3.3 0.1 0.7 -1.1 -0.9 1.7
Ulcerative Colitis (UC) 0.8 1.5 8.0 -0.8 2.8 0.1 0.5 -0.5 -0.2 1.1
Major Depression (MDD) 0.8 1.0 3.0 1.1 0.7 -0.7 1.7 0.2 0.7 1.0
Reaction Time 1.3 2.4 5.0 -1.8 -0.2 1.5 -2.2 -1.9 -0.7 -1.6
Verbal and Numeric Reasoning (VNR) 0.5 1.3 3.2 -1.2 -1.3 -1.8 -0.5 -0.0 -0.0 -1.6
Breast Cancer 2.0 4.7 12.3 1.4 0.2 3.5 2.9 -1.7 -1.8 2.1
Ovarian Cancer 1.6 2.1 5.9 1.7 1.5 -0.4 2.4 -0.0 -0.3 1.8
Prostate Cancer 0.1 0.1 0.6 -0.0 -0.0 0.8 -0.2 -0.1 0.3 -0.4
Age at First Birth 0.7 1.1 3.6 0.8 -0.7 0.3 0.2 -1.9 -1.6 -0.0
Bipolar Disorder (2011) 0.4 0.4 1.2 0.0 0.0 0.0 0.0 -1.1 -0.5 -1.0
Body Mass Index (BMI) (2010) 2.2 3.0 8.9 0.3 0.9 -1.6 -0.8 2.8 3.0 -0.0
Coronary Artery Disease (CAD) 4.8 5.8 16.0 -1.2 0.5 -1.8 -1.3 3.8 4.0 -1.8
Crohns Disease (2012) 0.3 0.4 2.2 0.3 1.5 0.4 0.4 0.3 -0.0 0.6
Mean Putamen Volume 0.5 0.6 1.6 1.3 1.0 -0.3 -0.6 -0.9 -0.2 0.5
Fasting Glucose 1.0 1.2 4.9 0.0 0.4 -0.0 0.5 -2.2 -1.8 0.4
HbA1C 0.2 0.2 0.8 0.1 -0.2 0.1 -0.6 -0.9 -0.3 -0.1
HDL Cholesterol 0.8 1.4 4.0 0.1 -0.2 0.1 1.5 -1.6 -2.0 0.8
LDL Cholesterol 1.2 2.0 7.5 -0.8 -0.8 -0.6 0.5 -2.1 -2.7 -0.3
Lupus 0.3 0.5 1.5 0.0 0.5 1.0 0.1 -1.2 -1.0 -0.1
Neuroticism (2016) 1.0 1.5 3.2 -1.0 -1.7 -1.8 1.3 0.7 0.1 -1.0
Primary Biliary Cirrhosis 0.6 0.9 1.7 1.2 0.9 0.2 1.3 0.4 0.9 1.2
Rheumatoid Arthritis 0.5 0.7 1.7 -0.2 -0.6 -1.3 -0.7 1.2 0.7 -0.8
Schizophrenia (2014) 3.6 7.9 29.1 -0.9 -0.9 1.4 0.6 -4.7 -5.4 0.1
Triglycerides 0.8 1.2 2.6 -0.6 -1.0 -0.6 -1.6 -1.4 -1.0 -1.2
Type 2 Diabetes (T2D) (2012) 1.3 1.5 3.6 -1.9 -0.3 0.4 -1.7 -1.0 -0.3 -1.6
Ulcerative Colitis 1.5 2.2 10.8 -0.0 3.3 0.0 1.4 0.1 0.4 1.7
Blood Eosinophil Count 0.2 1.7 4.3 -1.2 -0.7 0.9 -1.8 -1.3 -0.4 -2.1
Blood Platelet Count 10.2 118.4 334.9 -5.4 -8.7 3.2 -4.5 -18.3 -18.3 -5.0
Blood Red Count 0.7 6.8 20.6 1.6 0.9 0.6 1.6 4.5 4.5 0.6
Blood White Count 5.6 41.4 125.4 -3.6 -1.0 5.0 -2.1 -11.2 -10.8 -1.9
Heel T-Score 17.3 137.8 400.0 1.1 11.8 1.9 3.0 20.0 19.3 6.2
BMI 2.7 15.8 25.8 -1.6 -1.7 -5.1 -4.2 4.9 4.8 -3.9
Height 0.6 12.5 32.0 0.5 3.3 4.1 5.7 0.6 0.8 5.2
Waist Hip Ratio (WHR) 1.5 6.9 18.0 -1.1 -1.2 -1.2 -2.0 3.6 4.2 -3.0
Systolic Blood Pressure 7.6 37.9 77.4 -7.7 -8.6 -3.8 -5.8 -1.4 -2.5 -8.8
Smoking Status 6.8 16.3 32.7 5.0 5.7 2.9 4.1 1.7 1.6 5.1
Allergy or Eczema 4.2 11.0 16.8 3.7 2.3 2.8 3.2 -3.3 -3.5 4.1
Cardiovascular Disease 2.1 6.8 10.9 -2.9 -1.4 -2.4 -2.0 3.3 2.8 -3.0
Hypothyroidism (self reported) 0.7 1.7 4.7 1.0 2.2 -0.8 0.9 1.3 0.9 1.5
Respiratory disease 1.7 3.8 11.8 1.5 1.2 -0.2 0.2 3.4 3.3 0.3
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 0.7 0.2 0.2 -0.7 -0.5 0.2 -0.5
Lung FEV1/FVC ratio 5.3 26.9 89.9 -1.1 -2.9 1.3 -0.8 -9.2 -9.5 -0.7
Lung FVC 2.2 11.3 28.2 -4.5 -2.5 -1.9 -5.3 1.2 0.8 -4.2
Neuroticism 1.6 3.8 8.1 -2.6 -2.0 -2.8 -0.4 1.2 0.7 -2.4
Chronotype (morning person) 0.1 0.3 0.8 0.8 -0.5 0.2 0.9 0.5 0.2 0.5
Hair Pigment 0.0 1.1 3.9 1.1 0.6 0.4 0.4 1.3 2.0 -0.6
Tanning 0.3 3.2 9.3 -1.6 -3.0 -0.4 -2.3 -1.1 -1.5 -1.3
Hand grip strength (left) 1.3 3.3 5.1 -2.3 -1.8 -1.5 -1.3 2.0 1.6 -2.1
Number of treatments/medications taken 0.9 1.7 4.5 -0.3 -1.0 -1.0 -0.5 2.1 1.8 -1.2
Average weekly spirits intake 1.7 2.2 6.9 0.9 1.2 -0.1 0.4 2.6 2.0 1.4
Sensitivity / hurt feelings 0.4 0.7 2.4 -1.5 -0.6 -0.4 0.8 -0.1 -0.3 -0.9
Frequency of depressed mood in last 2 weeks 1.0 1.3 4.2 -0.6 0.2 -1.3 -0.6 2.0 1.7 0.1
Hearing difficulty/problems: Yes 1.1 1.6 8.4 0.0 -0.3 -1.4 2.9 0.8 0.4 0.4
Relative age of first facial hair 2.1 4.3 14.2 1.0 -0.4 0.7 0.2 -3.8 -3.8 0.1
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 2.0 -0.3 -0.4 1.2 -1.4 -0.5 -0.2 -0.8
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.7 0.8 0.0 0.3 0.5 -0.6 -0.5 0.5
Ever had hysterectomy (womb removed) 0.9 1.0 1.8 0.2 0.6 -1.1 1.0 1.3 1.3 0.9
Systolic blood pressure, automated reading 9.9 28.7 62.8 -6.7 -6.9 -3.8 -5.6 -0.2 -0.7 -7.9
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 2.1 -0.8 1.4 0.7 0.2 0.4 0.5 0.4
Angina 1.8 2.4 7.2 -0.9 -1.1 0.5 -0.5 2.2 2.7 -1.5
Medication for hormone replacement therapy 1.0 1.2 3.8 -0.9 -1.8 -0.4 -0.3 -0.2 -0.1 -2.0
Vitamin and mineral supplements 1.8 2.5 6.3 -0.9 0.3 -2.2 0.5 2.2 2.5 -0.6
Supplements: Zinc 2.4 2.6 4.2 1.9 1.2 2.1 1.4 -1.2 -1.1 2.0
Medication: Co-codamol 2.0 2.3 5.2 2.3 2.1 0.7 1.4 -0.6 -0.6 1.7
Medication: Metformin 0.7 1.0 1.7 1.1 -1.3 0.3 -0.8 -1.3 -0.8 -0.8
Diabetes (father) 1.8 2.3 7.9 0.5 -1.0 0.9 0.1 -2.8 -2.4 -0.5
Diabetes (mother) 1.5 2.0 6.7 -1.5 -0.9 -0.8 -2.6 -0.8 -0.7 -1.5
Severe depression (siblings) 0.9 1.0 2.1 1.4 1.4 0.5 0.9 0.2 0.3 1.3
Pack years adult smoking proportion 2.2 3.3 10.3 1.1 -1.3 -0.8 -0.8 -3.2 -3.0 -0.1
Impedance of leg (right) 5.7 27.7 62.6 0.8 0.2 6.3 4.6 -7.7 -7.9 3.2
Leg fat-free mass (left) 2.3 12.1 35.4 -0.2 1.1 -3.7 -1.4 6.0 5.7 -0.2
Trunk fat percentage 1.1 4.3 9.0 -1.7 -2.4 -2.7 -1.9 1.0 0.5 -3.0
Hand grip strength (right) 0.6 1.6 4.9 -2.2 -1.7 -0.3 -0.3 0.7 0.6 -1.7
Townsend deprivation index at recruitment 0.8 1.1 2.3 1.1 0.4 0.4 0.6 -1.5 -1.2 1.4
Current tobacco smoking 4.2 6.9 13.9 3.2 3.2 1.8 2.2 -1.5 -1.8 3.7
Average weekly fortified wine intake 2.9 3.4 8.4 1.2 2.9 1.8 1.4 1.2 0.9 2.5
Maternal smoking around birth 2.9 4.2 10.9 2.5 3.3 1.7 1.8 0.6 0.2 2.3
Fed-up feelings 0.6 1.0 2.7 1.4 0.2 -0.3 1.5 0.4 0.1 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.5 4.9 -0.7 0.6 -1.2 -0.5 2.2 1.8 0.2
Relative age voice broke 1.6 2.4 5.3 2.3 1.2 1.1 0.4 -1.9 -1.7 1.5
Taking other prescription medications 1.7 2.6 8.2 1.3 0.6 -0.6 0.9 2.7 2.9 0.1
Age when periods started (menarche) 1.8 4.4 9.7 1.6 0.5 3.1 1.8 -2.3 -2.6 1.8
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 0.3 0.5 0.0 0.5 0.1 0.3 0.6
Heel bone mineral density (BMD) T-score, automated (left) 12.9 29.3 82.7 2.0 5.5 0.6 2.9 9.1 8.3 3.2
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.1 1.0 0.9 0.3 -0.1 -0.4 -0.2 0.6
Qualifications: CSEs or equivalent 0.6 0.8 1.3 1.2 0.6 1.1 1.0 -1.0 -0.7 0.6
Serious illness, injury or assault to yourself 0.8 1.0 2.1 -0.5 -0.2 -0.8 -1.2 1.1 1.4 -1.2
High blood pressure 4.1 11.5 21.2 -2.3 -2.0 -3.3 -2.8 4.6 4.3 -3.6
Hayfever, allergic rhinitis or eczema 2.9 6.3 8.7 2.5 1.7 2.6 2.7 -2.6 -2.4 3.0
Multivitamins +/- minerals 0.8 1.0 3.5 0.4 -0.3 1.9 -0.6 -1.0 -1.4 0.3
Stomach or abdominal pain in last month 1.3 1.6 4.4 -0.2 1.3 0.6 0.2 2.1 2.0 0.9
Supplements: Glucosamine 1.4 1.9 4.0 -1.0 -0.7 0.0 -1.6 1.7 2.0 -1.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.3 0.8 1.5 0.1 0.5 0.7 0.5 1.1
Medication: Atenolol 2.6 3.2 9.7 -0.7 0.5 -1.9 0.0 2.8 3.1 -1.0
Medication: Levothyroxine sodium 0.5 0.8 1.7 -1.1 0.2 -1.3 -0.4 1.1 0.9 -0.6
Sitting height 0.3 1.8 8.2 -2.9 -1.7 0.1 -0.7 -0.4 -0.8 -0.8
Chronic bronchitis/emphysema (father) 0.2 0.2 0.5 0.1 -0.7 -0.4 -0.7 0.4 0.1 -0.5
High blood pressure (mother) 0.2 0.3 0.9 0.1 -1.0 0.4 -0.7 -0.3 -0.2 -0.8
Body mass index (BMI) 2.7 11.4 26.6 -0.5 -0.5 -4.4 -2.3 5.2 4.8 -2.2
Impedance of leg (left) 6.2 30.2 68.6 1.0 0.2 6.8 4.4 -8.1 -8.3 3.3
Leg predicted mass (left) 2.3 12.2 35.2 -0.2 1.1 -3.8 -1.4 5.9 5.7 -0.2
Trunk fat mass 0.9 3.8 6.9 -1.1 -1.3 -2.6 -1.3 2.6 2.1 -1.9
Waist circumference 2.3 8.3 21.4 -0.6 -0.6 -3.2 -1.5 4.6 4.5 -1.9
Number of incorrect matches in round 0.8 1.3 2.9 -0.5 -1.0 1.7 -1.3 -1.1 -1.3 -0.3
Past tobacco smoking 3.0 5.5 9.2 -2.3 -3.0 -2.8 -2.1 -1.4 -1.8 -2.6
Alcohol usually taken with meals 0.9 1.4 4.5 -0.5 1.3 0.1 0.7 1.3 2.1 1.1
Nervous feelings 7.7 14.3 26.7 -5.1 -4.3 -3.7 -3.9 -0.4 -0.8 -5.2
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 5.4 -1.5 -0.7 -2.2 -1.1 2.3 1.8 -0.8
Hearing difficulty/problems with background noise 1.6 2.5 13.4 0.3 1.1 -0.5 3.7 0.8 0.5 1.4
Hair/balding pattern: Pattern 2 3.2 4.1 12.5 -0.6 -0.6 0.6 1.5 -3.4 -3.5 1.1
Had menopause 1.1 1.4 3.5 -1.1 -0.8 -1.9 -1.3 -1.2 -0.8 -0.9
Had other major operations 1.7 2.1 3.4 0.2 1.7 1.8 0.3 1.8 1.7 1.5
Forced vital capacity (FVC) 0.8 3.1 8.9 -3.0 -0.2 -0.5 -2.2 1.8 1.5 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 10.0 22.9 68.1 1.6 4.3 0.5 2.8 8.3 7.5 2.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.8 -1.4 0.4 -0.7 -1.0 -0.7 -0.4 -0.9
Qualifications: None of the above 0.6 1.4 3.3 -1.1 -1.6 -0.8 -1.8 0.1 -0.3 -1.3
Financial difficulties in last 2 years 0.4 0.5 1.6 -1.3 -0.0 -0.0 -0.1 -0.2 -1.2 -0.6
Mouth/teeth dental problems 0.4 0.6 2.4 -0.3 -0.0 0.1 1.5 -0.4 -1.1 0.7
Heart attack 2.6 3.3 11.4 -0.7 -0.3 -0.3 -0.3 3.4 3.3 -0.2
Allergy 1.9 4.4 8.2 -2.1 -2.4 -2.3 -2.6 0.5 0.3 -2.9
Pain all over the body in last month 0.4 0.5 1.7 -0.9 -0.2 -0.2 -0.8 -0.0 -0.3 -1.3
Diabetes (self-reported) 1.1 1.7 4.8 -0.3 -1.6 -0.9 -1.5 0.4 1.2 -2.2
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 3.5 1.6 1.7 0.9 1.9 -1.2 -0.5 1.4
Medication: Ramipril 1.9 2.4 6.5 -1.2 -0.2 0.7 -1.7 2.1 2.5 -1.1
Medication: Simvastatin 1.2 1.7 6.4 -0.1 0.8 -0.9 0.6 2.5 1.9 -0.1
Fluid intelligence score 0.5 0.9 2.5 -0.2 -0.8 -1.5 1.6 0.9 0.5 -0.3
Illnesses of siblings 3.3 4.6 16.0 0.3 0.4 0.6 0.7 -4.0 -3.8 0.7
Neuroticism score 1.7 3.5 6.6 -2.6 -2.0 -2.2 -1.1 1.3 0.9 -2.2
Weight 1.7 8.3 26.4 0.0 0.6 -2.9 -0.8 5.1 4.7 -0.2
Impedance of arm (right) 3.7 17.1 37.7 -2.9 -4.8 0.6 -1.1 -6.1 -6.0 -3.5
Arm fat percentage (right) 2.8 11.0 21.0 -1.8 -3.0 -4.6 -2.9 3.2 2.8 -4.2
Trunk fat-free mass 2.6 14.9 39.4 1.6 3.8 -0.9 1.4 6.3 6.0 3.1
Hip circumference 0.7 3.1 9.0 -0.3 -0.7 -3.0 -0.7 2.6 2.1 -0.6
Time employed in main current job 0.3 0.4 0.8 0.5 0.5 0.4 -0.6 0.9 0.9 0.3
Alcohol intake versus 10 years previously 0.9 1.4 4.7 -1.1 -0.9 -0.2 -2.2 -0.4 0.4 -1.6
Father’s age at death 2.2 2.9 5.8 2.0 0.9 0.1 1.4 -2.4 -2.1 1.8
Worrier / anxious feelings 1.7 3.3 10.0 -3.2 -2.0 -1.6 -1.0 -0.4 -0.5 -2.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 1.8 0.2 1.4 -1.2 1.1 1.3 0.6 1.1
Falls in the last year 0.1 0.2 0.7 -0.4 0.1 -0.1 0.2 0.7 0.9 -0.1
Hair/balding pattern: Pattern 3 0.8 1.2 3.6 -1.4 0.2 0.8 0.4 1.9 1.3 -0.5
Number of live births 0.7 1.0 3.1 1.0 0.7 0.1 0.5 1.8 1.3 0.6
Forced expiratory volume in 1-second (FEV1) 0.8 2.7 9.9 -3.1 -0.8 -0.4 -2.2 -0.5 -1.0 -1.4
Pulse rate 0.3 0.4 2.0 -1.4 0.6 0.8 0.2 0.2 0.2 -0.1
Happiness 1.2 1.4 3.1 0.5 -0.4 1.3 1.8 -1.4 -1.7 0.6
Noisy workplace 0.3 0.3 1.2 -0.6 -0.4 -0.2 -0.5 0.2 0.4 -1.1
Qualifications: A levels/AS levels or equivalent 1.4 3.1 8.4 0.7 0.6 1.7 1.6 -2.9 -2.3 1.6
Serious illness, injury or assault of a close relative in last 2 years 2.3 2.6 6.4 1.4 2.5 2.0 1.2 0.6 1.1 1.7
Mouth/teeth dental problems: Dentures 0.6 1.1 2.4 -0.9 -0.6 0.5 -1.6 1.0 1.0 -1.3
Asthma 1.3 2.6 8.1 1.0 1.4 0.2 0.4 2.8 2.5 0.4
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.7 7.7 -0.1 -0.3 0.7 -1.7 -2.7 -2.8 -0.6
Medication: Cholesterol lowering 1.0 1.6 5.4 0.3 0.1 0.4 1.0 2.3 2.1 0.2
Depression (self-reported) 0.9 1.1 2.7 1.0 1.4 -0.2 -0.5 0.8 1.6 1.0
Medication: Lansoprazole 2.0 2.3 6.8 -0.9 1.1 0.9 -0.9 2.6 2.3 -0.1
Prospective memory result 0.9 1.1 3.3 -0.4 -0.7 -1.0 -1.8 -0.9 -0.9 -1.0
Lung cancer (father) 0.4 0.5 2.0 0.8 0.2 1.4 -0.0 -0.2 -0.4 0.8
Illnesses of mother 0.2 0.2 0.7 -0.2 -0.1 -0.2 0.3 -0.4 -0.9 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.4 13.2 -3.6 -0.8 -0.0 -2.3 -0.7 -1.0 -1.8
Pulse wave Arterial Stiffness index 0.7 0.8 2.4 -1.0 0.0 0.9 -0.4 -1.1 -1.6 -0.2
Impedance of arm (left) 3.5 16.3 43.1 -2.4 -3.6 1.5 -0.5 -6.6 -6.5 -2.6
Arm fat mass (right) 2.2 9.0 16.8 -1.3 -1.3 -4.0 -2.4 4.1 3.7 -2.8
Trunk predicted mass 2.6 14.7 39.6 1.5 3.7 -0.9 1.4 6.3 6.0 3.0
Standing height 0.6 5.8 16.0 1.0 2.5 2.7 3.0 0.8 0.8 4.0
Length of working week for main job 2.8 3.1 11.1 -1.0 0.3 -0.9 -0.6 3.3 2.9 -0.5
Exposure to tobacco smoke at home 1.5 1.7 4.0 -0.4 -0.6 -1.6 -0.2 1.8 2.0 -1.1
Breastfed as a baby 1.1 1.4 2.6 -0.8 -1.4 0.3 -1.6 0.9 1.3 -1.4
Tense / ‘highly strung’ 1.6 2.6 8.4 -2.9 -1.1 -2.3 -1.0 0.7 0.4 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.1 6.4 0.9 1.2 -0.8 0.8 1.7 2.5 1.2
Hair/balding pattern: Pattern 4 6.3 15.2 28.0 -3.1 -5.0 -5.3 -4.4 -0.6 -1.1 -4.7
Birth weight of first child 2.0 3.7 9.9 -0.6 -2.3 0.2 -1.0 -3.1 -2.6 -1.5
Peak expiratory flow (PEF) 0.1 0.2 0.3 -0.5 -0.6 -0.3 -0.4 -0.1 -0.5 -0.1
Pulse wave reflection index 1.0 1.3 3.9 0.3 -0.1 0.6 1.1 -1.6 -2.0 0.9
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.8 -0.1 0.7 -0.7 0.6 0.2 -0.1 0.9
Loud music exposure frequency 0.8 0.9 2.4 -1.4 -0.3 0.2 0.2 -1.1 -1.6 -0.7
Qualifications: O levels/GCSEs or equivalent 2.9 4.6 13.6 2.7 1.6 1.0 3.7 -0.8 -0.8 2.5
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.8 -0.8 0.6 -0.8 -0.9 0.2 0.9 -0.3
Blood clot in the leg (DVT) 2.6 3.3 12.1 0.7 3.5 1.7 0.6 1.0 2.0 1.7
Medication: Paracetamol 1.5 2.4 6.7 0.6 0.2 1.5 1.5 -2.6 -2.2 0.5
Headache pain in last month 2.1 3.6 10.1 -1.7 -1.1 0.6 -1.2 -3.2 -3.1 -0.6
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 9.4 1.1 0.2 1.2 0.1 -3.1 -2.6 0.9
Glaucoma (self-reported) 3.7 4.4 11.3 -0.5 0.3 2.4 1.6 -3.4 -3.0 1.3
Gout (self-reported) 1.6 2.3 3.8 -1.2 -1.9 -0.7 -2.0 1.1 1.1 -2.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.0 0.0 1.3 -0.9 0.1 1.4 0.8 0.7
Medication: Amlodipine 1.8 2.5 8.5 0.3 0.4 -1.8 -0.4 2.9 2.3 0.0
Medication: Ventolin 100micrograms inhaler 0.9 1.1 3.5 -0.6 0.3 1.1 0.5 1.9 1.5 -0.2
Birth weight 4.6 9.9 21.0 -2.8 -4.6 -3.0 -3.7 0.6 0.4 -4.2
Chronic bronchitis/emphysema (mother) 1.3 1.5 5.4 0.8 2.3 0.3 1.1 1.1 0.9 1.1
High blood pressure (siblings) 4.1 5.8 19.5 -0.2 -0.1 -0.9 -1.2 4.4 4.3 -0.9
Forced vital capacity (FVC), Best measure 0.8 2.9 11.8 -3.4 -0.2 0.0 -1.8 1.2 1.0 -1.6
Body fat percentage 0.9 3.6 7.1 -1.4 -2.1 -2.6 -1.6 1.3 0.8 -2.7
Leg fat percentage (right) 0.1 0.5 1.6 0.1 -0.7 -1.0 0.2 1.2 0.6 -0.5
Arm fat-free mass (right) 2.4 12.4 28.7 1.7 4.2 -0.6 1.1 5.4 5.2 3.1
Exposure to tobacco smoke outside home 2.2 3.0 8.3 -1.3 -2.9 -1.5 -1.9 -0.2 -0.9 -2.0
Comparative body size at age 10 7.7 21.2 38.8 -3.6 -3.9 -6.2 -5.0 4.2 4.0 -4.8
Number of full brothers 1.8 2.2 6.0 -1.2 -1.5 1.2 -0.5 -1.9 -2.4 -0.6
Worry too long after embarrassment 1.4 2.4 6.5 -2.1 -0.8 -2.5 0.2 1.6 0.6 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.3 0.1 -1.2 -0.8 -0.4 0.1 0.4 -0.9
Wheeze or whistling in the chest in last year 1.6 2.8 8.0 0.6 1.8 -0.3 0.8 2.8 2.4 1.2
Number of children fathered 0.4 0.4 0.9 0.8 -0.9 0.1 -0.0 0.8 0.7 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 4.1 -2.0 -0.5 -0.0 0.2 -1.0 -0.9 -0.9
Age at first live birth 0.1 0.2 0.4 -0.7 0.7 0.5 0.4 0.1 0.3 0.3
Pulse wave peak to peak time 0.7 0.9 2.2 1.2 0.4 -0.3 0.9 1.0 1.5 0.7
Health satisfaction 1.5 1.9 4.9 -0.9 -0.4 -0.6 -0.4 2.0 2.2 -1.7
Shortness of breath walking on level ground 2.0 2.4 7.0 0.9 1.1 -0.8 0.9 2.4 2.6 0.6
Qualifications: College or University degree 0.6 1.9 7.9 -0.5 -0.5 0.2 -1.1 -2.8 -1.8 -0.2
Eye problems/disorders: None of the above 1.3 1.5 3.8 -0.6 -1.5 -1.9 -0.4 1.1 0.6 -1.7
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.1 1.5 0.8 -1.1 -0.2 -0.4 0.8 -0.1
Emphysema/chronic bronchitis 1.1 1.3 2.8 1.3 0.6 -1.6 0.0 0.8 1.7 -1.1
Medication for pain relief, constipation, heartburn 0.4 0.7 1.7 0.6 0.2 -1.0 0.1 1.3 1.3 0.5
Neck or shoulder pain in last month 0.4 0.6 1.5 -1.2 0.5 0.3 -0.3 1.1 1.0 -0.2
Medication: Blood pressure 1.7 3.0 7.8 -1.4 -0.8 -1.6 -0.8 2.8 2.4 -1.5
Angina (self-reported) 1.7 2.2 7.3 -0.5 -0.8 0.5 -0.3 2.3 2.7 -1.1
Migraine (self-reported) 1.6 1.9 5.4 -0.2 -1.7 0.8 -0.7 -2.3 -1.9 -0.7
Medication: Ibuprofen 1.4 1.7 5.2 0.3 -0.5 0.4 -1.3 -2.0 -2.3 -0.5
Medication: Allopurinol 0.5 0.7 1.2 -0.6 -1.1 -0.6 -0.9 1.0 0.7 -0.8
Medication: Omeprazole 1.4 1.7 3.6 1.5 1.3 1.4 1.9 -0.4 0.1 1.3
Medication: Seretide 50 evohaler 0.6 0.7 1.9 -0.2 0.9 1.4 0.8 0.6 0.9 0.8
Mean time to correctly identify matches 1.0 1.9 4.1 -1.5 -0.4 1.5 -2.0 -1.4 -0.2 -1.6
Heart disease (mother) 1.4 1.7 4.0 0.4 0.0 0.6 1.8 2.0 2.0 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.6 0.7 0.1 -0.5 1.3 1.2 0.9 -0.1
Whole body fat mass 1.0 4.4 8.7 -1.0 -1.1 -2.9 -1.4 2.9 2.5 -1.9
Leg fat mass (right) 0.8 3.2 9.7 -0.2 -0.3 -2.2 -0.5 3.1 2.6 -0.7
Arm predicted mass (right) 2.2 11.5 27.0 1.6 4.0 -0.9 1.1 5.2 5.0 2.9
Pulse rate, automated reading 0.1 0.5 1.0 -0.9 1.0 -0.3 -0.3 0.9 0.6 -0.4
Alcohol intake frequency. 0.8 1.8 3.7 -1.1 -0.5 0.2 -1.9 -1.9 -1.4 -1.3
Comparative height size at age 10 0.3 1.5 5.5 -0.5 0.9 0.5 0.6 1.5 2.4 1.0
Number of full sisters 0.6 0.8 1.8 -0.4 1.3 1.3 1.1 0.0 -0.0 0.7
Suffer from ‘nerves’ 6.9 10.8 22.5 -3.9 -4.7 -2.3 -3.2 -0.2 -0.2 -4.7
Overall health rating 0.6 1.3 3.0 -1.7 0.5 -0.9 -0.6 1.5 1.0 -1.2
Chest pain or discomfort 0.5 0.7 1.9 0.1 0.4 -0.9 0.8 1.0 1.4 -0.6
Had major operations 3.7 4.3 10.2 -1.6 -2.1 -1.6 -1.4 1.7 2.4 -3.2
Age at last live birth 0.9 1.3 3.6 0.4 1.9 1.6 0.6 -0.3 -0.2 1.4
Family relationship satisfaction 1.1 1.3 3.9 -0.0 0.3 0.8 0.9 -2.0 -1.9 -0.1
Leg pain on walking 1.7 2.1 5.5 -1.6 -1.6 -0.2 -2.4 -0.4 -1.0 -1.7
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.9 -1.0 -0.6 0.4 -1.3 -1.3 -1.0 -1.7
Commuting to job workplace: Car/motor vehicle 1.4 1.6 6.8 0.2 -2.6 -0.3 -0.8 0.8 0.8 -1.5
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.5 0.5 -0.7 -1.2 0.9 0.5 0.3 0.6
Medication: Aspirin 2.8 3.7 6.1 -1.6 -1.7 -1.5 -2.2 2.0 1.8 -2.5
Supplements: Vitamin C 1.0 1.2 4.0 0.4 0.6 2.0 -0.3 -1.3 -1.4 0.6
Knee pain experienced in last month 2.4 3.8 9.1 -1.7 -1.1 -1.4 -3.0 2.0 1.6 -2.2
Hypertension (Self-reported) 3.9 10.8 21.0 -2.2 -2.0 -3.5 -2.3 4.6 4.1 -3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.6 -1.2 0.5 0.6 0.3 -0.6 -0.7 -0.1
Illnesses of father: Heart disease 5.0 7.0 27.4 -1.4 2.0 -0.1 0.7 3.8 5.2 -0.7
Illnesses of siblings: Diabetes 0.1 0.1 0.4 0.6 0.0 0.4 0.0 -0.3 -0.1 0.1
Smoking status: Previous 1.8 2.6 5.7 1.3 1.7 1.7 1.1 1.8 2.4 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 3.0 -0.4 0.8 1.7 0.8 -0.7 -1.3 1.7
Whole body fat-free mass 2.3 13.3 39.1 1.0 3.0 -2.0 0.3 6.2 6.0 1.9
Leg fat-free mass (right) 2.2 11.7 33.9 0.0 1.2 -3.6 -1.5 5.8 5.6 -0.0
Arm fat percentage (left) 2.4 9.4 17.7 -1.7 -2.5 -4.2 -2.8 3.0 2.5 -4.0
Average weekly red wine intake 0.5 0.8 2.1 -1.5 -0.6 -1.1 0.4 0.7 0.9 -0.6
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.8 -0.8 0.3 -0.0 -0.5 -0.9 -0.2 -0.7
Mood swings 1.1 2.0 7.0 -2.0 -2.6 -0.9 -0.4 0.2 0.2 -1.4
Loneliness, isolation 0.6 0.9 3.3 -1.0 -1.8 0.1 -0.7 -0.4 -0.5 -1.0
Long-standing illness, disability or infirmity 0.9 1.4 4.3 0.5 -0.4 -0.2 -0.8 2.1 2.0 -0.3
Ever had bowel cancer screening 2.9 3.4 10.6 0.3 0.7 -1.4 0.6 3.2 3.3 -0.0
Diabetes diagnosed by doctor 0.7 1.2 3.9 -0.3 -0.8 -0.2 -2.0 -0.8 -0.1 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.3 -0.2 1.3 0.0 1.0 1.5 1.5 0.5
Friendships satisfaction 0.5 0.7 1.7 -1.3 -0.8 0.4 0.4 -0.9 -1.0 -0.4
Qualifications: nursing, teaching 1.0 1.6 3.1 -0.0 1.3 1.3 0.9 -1.8 -1.5 1.1
Commuting to job workplace: Walk 1.6 1.7 5.9 0.0 0.1 0.0 -0.2 -2.4 -2.4 0.5
Eye problems/disorders: Cataract 0.4 0.5 1.6 -0.3 1.3 -0.4 -0.6 0.9 0.7 0.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.2 1.0 -0.5 -1.1 -0.2 -0.6 -0.2 -0.0
Medication for cholesterol 2.2 3.3 8.8 1.0 0.9 1.4 0.3 -3.0 -2.8 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 6.4 0.4 0.4 -0.0 -0.2 2.5 2.1 0.6
Back pain experienced in last month 1.3 2.0 5.5 2.3 1.8 1.7 0.7 -0.3 0.2 1.2
Mineral and other dietary supplements 0.6 0.8 1.7 0.1 1.3 -0.1 1.2 0.9 1.2 0.4
Breast cancer (self-reported) 0.7 0.8 2.1 -0.1 -0.8 -1.4 -0.9 0.0 0.6 -1.4
Asthma (self-reported) 0.9 1.8 5.4 1.0 1.3 0.7 0.3 2.3 2.0 0.4
Osteoporosis (self-reported) 1.4 1.8 2.7 -0.6 -1.6 -1.0 -1.6 -1.2 -1.4 -1.6
Osteoarthritis (self-reported) 3.1 4.0 7.5 2.0 2.7 1.8 1.5 1.2 2.1 2.3
Medication: Aspirin 3.1 4.0 5.7 -1.6 -1.3 -1.9 -1.8 2.4 2.3 -2.4
Medication: Gliclazide 2.8 3.1 8.7 -0.4 -3.0 -0.8 -2.7 0.7 0.5 -2.1
Illnesses of father: None of the above (group 1) 1.2 1.5 5.9 0.9 -0.2 0.5 0.3 -1.7 -2.4 0.7
Smoking status: Current 5.6 9.0 19.1 3.4 3.9 2.3 2.7 -1.3 -1.6 4.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.4 7.2 16.1 -4.0 -2.4 -1.9 -3.1 0.6 0.6 -3.9
Whole body water mass 2.3 12.9 37.9 1.0 3.0 -2.0 0.2 6.2 5.9 1.9
Leg predicted mass (right) 2.2 11.8 34.0 -0.1 1.2 -3.6 -1.6 5.8 5.6 -0.2
Arm fat mass (left) 1.9 7.6 15.7 -0.9 -0.9 -3.6 -2.0 4.0 3.6 -2.4
Number of self-reported non-cancer illnesses 1.4 2.4 9.1 0.1 1.4 -0.1 0.7 2.4 3.0 -0.2
Average weekly champagne plus white wine intake 0.8 1.1 4.0 -0.1 0.3 0.0 0.6 2.0 1.8 0.5
Miserableness 0.5 0.8 3.5 -0.2 -0.8 -1.9 0.8 0.8 0.4 -0.2
Guilty feelings 2.1 3.2 7.5 -0.5 0.1 -2.7 1.5 2.7 2.2 -0.6
Wears glasses or contact lenses 0.6 0.7 1.9 -1.4 -1.2 -0.2 0.3 0.7 0.5 -0.7
Ever taken oral contraceptive pill 1.6 1.8 4.3 -2.1 -1.2 1.0 -1.1 -1.5 -1.2 -1.1
Hearing aid user 0.5 0.5 1.6 1.0 -0.9 -0.3 1.3 -0.0 -0.1 0.5
Mother’s age at death 1.5 1.8 4.5 0.0 -1.1 0.7 -1.5 -2.1 -2.0 0.5
Financial situation satisfaction 0.6 0.8 2.7 -0.3 1.5 1.6 0.4 -0.0 -0.3 0.4
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.3 -0.6 0.2 -0.5 0.3 1.2 0.4 0.8
Commuting to job workplace: Public transport 1.0 1.1 2.0 0.7 1.4 0.3 1.1 -1.3 -0.9 1.4
Eye problems/disorders: Glaucoma 2.4 2.8 5.5 0.1 0.7 2.3 1.6 -2.2 -1.9 1.7
Medication: Blood pressure 2.4 4.5 12.7 -1.3 0.2 -1.6 -0.9 3.4 3.6 -1.4
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.1 -0.0 0.8 0.3 -0.1 -1.1 -0.8 -0.2
Supplements: Fish oil (including cod liver oil) 1.0 1.2 2.4 -1.1 -1.2 -0.1 -1.1 -1.3 -1.5 -0.8
High cholesterol (Self-reported) 0.1 0.2 0.5 -0.4 0.4 0.4 0.7 -0.2 -0.2 0.2
Medication: Bendroflumethiazide 1.0 1.5 4.2 -0.7 -1.2 -0.6 -0.9 2.0 1.3 -1.3
Medication: Paracetamol 0.6 0.9 2.7 -0.6 0.0 0.8 0.7 -1.7 -1.5 -0.2
Medication: Lisinopril 1.1 1.4 2.7 -0.4 1.3 -1.3 1.5 1.6 1.2 0.4
Medication: Atorvastatin 0.4 0.5 1.2 0.6 -0.8 0.5 -0.1 -1.1 -1.0 0.1
Illnesses of father: High blood pressure 0.8 1.0 2.2 -0.9 -1.0 -1.0 0.4 0.9 1.0 -1.5
Alcohol drinker status: Never 1.0 1.1 3.3 -1.1 -0.6 -0.5 -1.8 -1.0 -1.0 -1.0
Ever smoked 3.4 5.9 10.9 2.6 3.0 3.3 2.0 0.6 0.9 3.1
Basal metabolic rate 2.1 11.4 34.8 0.8 2.4 -2.3 0.1 5.9 5.6 1.4
Leg fat percentage (left) 0.2 0.7 2.2 0.2 -0.7 -1.0 -0.1 1.5 0.8 -0.6
Arm fat-free mass (left) 2.2 10.9 30.2 1.3 3.1 -1.5 0.7 5.5 5.2 2.3
Number of operations (self-reported) 1.5 2.3 9.1 -0.1 -0.2 -0.2 -0.9 2.3 3.0 -0.9
Average weekly beer plus cider intake 0.4 0.6 2.1 0.3 -0.2 -1.3 -1.5 0.7 0.2 -0.4
Irritability 0.5 0.8 2.6 1.4 0.6 0.6 0.4 0.3 0.7 1.6
Risk taking 1.3 1.9 5.0 -0.9 0.7 2.2 -0.9 -1.8 -1.5 0.7
Ever had prostate specific antigen (PSA) test 2.6 3.0 11.3 -0.6 -0.0 -1.3 0.6 3.4 2.6 0.2
Fractured/broken bones in last 5 years 0.4 0.5 1.3 -0.9 -0.1 -1.1 -0.6 -0.5 -0.6 -0.8
Age started oral contraceptive pill 0.9 1.2 3.5 -0.8 -1.1 -0.1 -0.3 -1.9 -1.6 -0.3
Diastolic blood pressure, automated reading 6.1 19.1 39.3 -4.8 -4.9 -4.0 -4.7 2.2 2.0 -6.3
Ever depressed for a whole week 0.2 0.2 0.6 -0.4 0.7 -0.8 -0.0 0.1 0.3 0.1
Unable to work because of sickness or disability 0.2 0.2 0.6 -0.8 0.1 0.3 0.2 0.8 0.2 0.3
Commuting to job workplace: Cycle 0.9 1.1 2.4 1.6 1.0 0.7 0.8 0.8 1.2 1.0
Myopia 0.6 0.9 2.7 1.6 0.8 -0.5 1.0 0.4 0.4 1.1
Vascular/heart problems diagnosed by doctor 4.8 13.2 24.5 2.7 2.1 3.0 3.2 -5.0 -4.7 3.7
Cholesterol lowering medication 0.4 0.6 2.3 -0.7 -0.1 -0.3 0.2 1.5 1.2 -0.4
Medication: Omeprazole (e.g. Zanprol) 2.6 3.2 7.6 1.7 2.0 1.5 2.8 -0.3 0.0 2.3
Pain experienced in last month 0.1 0.2 0.7 0.4 -0.4 0.2 0.8 -0.2 -0.3 0.4
Supplements: Calcium 0.9 1.0 1.5 0.9 0.5 1.2 -1.1 -1.2 -1.2 0.1
Basal cell carcinoma (self-reported) 3.0 3.6 9.1 -0.4 3.0 2.7 1.0 -0.7 -0.9 2.4
Heart attack/myocardial infarction (self-reported) 2.4 3.1 11.0 -0.6 -0.3 -0.5 -0.4 3.3 3.2 -0.3
Deep venous thrombosis (DVT) (self-reported) 3.0 3.9 13.2 1.0 3.6 1.7 0.7 1.3 2.1 1.8
Heart disease (siblings) 1.3 1.6 5.4 -0.9 0.3 -0.1 -0.3 1.9 2.3 -1.1
Alcohol drinker status: Previous 0.3 0.4 0.6 -0.7 -0.1 -0.7 -0.6 0.6 0.6 -0.8
Pack years of smoking 2.1 3.1 9.5 1.2 -1.5 -0.5 -0.7 -3.1 -2.8 -0.2
Impedance of whole body 4.5 23.0 67.1 -1.1 -2.4 4.2 1.8 -8.2 -8.2 -0.2
Leg fat mass (left) 0.9 3.5 10.6 -0.2 -0.3 -2.3 -0.6 3.3 2.7 -0.7
Arm predicted mass (left) 2.0 10.2 27.0 1.2 3.2 -1.2 0.7 5.2 5.0 2.3