TWAS hub - SMG6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0400	0.0190	1.7e-02	0.048	0.013	0.033	0.017	0.041	1.4e-06	8.4e-03	6.0e-05	3.0e-03	8.9e-06
2	GTEx	Brain Cerebellum	0.2370	0.0890	9.4e-03	0.027	NA	0.050	NA	0.050	5.5e-02	NA	1.3e-02	NA	1.4e-02
3	GTEx	Testis	0.2800	0.0790	1.3e-05	0.070	NA	0.137	NA	0.124	4.8e-04	NA	1.2e-06	NA	4.0e-06
4	ROSMAP	Brain Pre-frontal Cortex	0.1015	0.0293	1.1e-05	0.027	0.042	0.034	0.041	0.037	1.9e-04	4.0e-06	3.1e-05	4.7e-06	1.5e-05
5	TCGA	Breast Invasive Carcinoma	0.0267	0.0160	1.0e-03	0.008	0.009	0.009	NA	0.006	6.2e-03	4.8e-03	5.6e-03	NA	2.0e-02
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0780	0.0360	1.3e-04	0.050	0.065	0.051	NA	0.046	7.7e-04	1.3e-04	7.2e-04	NA	1.2e-03
7	TCGA	Prostate Adenocarcinoma	0.0388	0.0209	4.4e-03	0.008	0.017	0.010	NA	0.012	4.4e-02	5.5e-03	3.0e-02	NA	1.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Heel T-Score	17.3	137.8	400.0	1.1	11.8	1.9	3.0	20.0	19.3	6.2
Heel bone mineral density (BMD) T-score, automated (left)	12.9	29.3	82.7	2.0	5.5	0.6	2.9	9.1	8.3	3.2
Blood Platelet Count	10.2	118.4	334.9	-5.4	-8.7	3.2	-4.5	-18.3	-18.3	-5.0
Heel bone mineral density (BMD) T-score, automated (right)	10.0	22.9	68.1	1.6	4.3	0.5	2.8	8.3	7.5	2.6
Systolic blood pressure, automated reading	9.9	28.7	62.8	-6.7	-6.9	-3.8	-5.6	-0.2	-0.7	-7.9
Nervous feelings	7.7	14.3	26.7	-5.1	-4.3	-3.7	-3.9	-0.4	-0.8	-5.2
Comparative body size at age 10	7.7	21.2	38.8	-3.6	-3.9	-6.2	-5.0	4.2	4.0	-4.8
Systolic Blood Pressure	7.6	37.9	77.4	-7.7	-8.6	-3.8	-5.8	-1.4	-2.5	-8.8
Suffer from ‘nerves’	6.9	10.8	22.5	-3.9	-4.7	-2.3	-3.2	-0.2	-0.2	-4.7
Smoking Status	6.8	16.3	32.7	5.0	5.7	2.9	4.1	1.7	1.6	5.1
Hair/balding pattern: Pattern 4	6.3	15.2	28.0	-3.1	-5.0	-5.3	-4.4	-0.6	-1.1	-4.7
Impedance of leg (left)	6.2	30.2	68.6	1.0	0.2	6.8	4.4	-8.1	-8.3	3.3
Diastolic blood pressure, automated reading	6.1	19.1	39.3	-4.8	-4.9	-4.0	-4.7	2.2	2.0	-6.3
Impedance of leg (right)	5.7	27.7	62.6	0.8	0.2	6.3	4.6	-7.7	-7.9	3.2
Blood White Count	5.6	41.4	125.4	-3.6	-1.0	5.0	-2.1	-11.2	-10.8	-1.9
Smoking status: Current	5.6	9.0	19.1	3.4	3.9	2.3	2.7	-1.3	-1.6	4.4
Worry (Nagel 2018)	5.5	11.6	20.4	-4.3	-4.5	-4.1	-2.4	-0.2	-0.3	-4.5
Lung FEV1/FVC ratio	5.3	26.9	89.9	-1.1	-2.9	1.3	-0.8	-9.2	-9.5	-0.7
Illnesses of father: Heart disease	5.0	7.0	27.4	-1.4	2.0	-0.1	0.7	3.8	5.2	-0.7
Coronary Artery Disease (CAD)	4.8	5.8	16.0	-1.2	0.5	-1.8	-1.3	3.8	4.0	-1.8
Vascular/heart problems diagnosed by doctor	4.8	13.2	24.5	2.7	2.1	3.0	3.2	-5.0	-4.7	3.7
Birth weight	4.6	9.9	21.0	-2.8	-4.6	-3.0	-3.7	0.6	0.4	-4.2
Impedance of whole body	4.5	23.0	67.1	-1.1	-2.4	4.2	1.8	-8.2	-8.2	-0.2
Allergy or Eczema	4.2	11.0	16.8	3.7	2.3	2.8	3.2	-3.3	-3.5	4.1
Current tobacco smoking	4.2	6.9	13.9	3.2	3.2	1.8	2.2	-1.5	-1.8	3.7
High blood pressure	4.1	11.5	21.2	-2.3	-2.0	-3.3	-2.8	4.6	4.3	-3.6
High blood pressure (siblings)	4.1	5.8	19.5	-0.2	-0.1	-0.9	-1.2	4.4	4.3	-0.9
Hypertension (Self-reported)	3.9	10.8	21.0	-2.2	-2.0	-3.5	-2.3	4.6	4.1	-3.3
Impedance of arm (right)	3.7	17.1	37.7	-2.9	-4.8	0.6	-1.1	-6.1	-6.0	-3.5
Glaucoma (self-reported)	3.7	4.4	11.3	-0.5	0.3	2.4	1.6	-3.4	-3.0	1.3
Had major operations	3.7	4.3	10.2	-1.6	-2.1	-1.6	-1.4	1.7	2.4	-3.2
Schizophrenia (2014)	3.6	7.9	29.1	-0.9	-0.9	1.4	0.6	-4.7	-5.4	0.1
Impedance of arm (left)	3.5	16.3	43.1	-2.4	-3.6	1.5	-0.5	-6.6	-6.5	-2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.4	7.2	16.1	-4.0	-2.4	-1.9	-3.1	0.6	0.6	-3.9
Ever smoked	3.4	5.9	10.9	2.6	3.0	3.3	2.0	0.6	0.9	3.1
Illnesses of siblings	3.3	4.6	16.0	0.3	0.4	0.6	0.7	-4.0	-3.8	0.7
Hair/balding pattern: Pattern 2	3.2	4.1	12.5	-0.6	-0.6	0.6	1.5	-3.4	-3.5	1.1
Osteoarthritis (self-reported)	3.1	4.0	7.5	2.0	2.7	1.8	1.5	1.2	2.1	2.3
Medication: Aspirin	3.1	4.0	5.7	-1.6	-1.3	-1.9	-1.8	2.4	2.3	-2.4
Neuroticism (Nagel 2018)	3.0	6.9	13.7	-3.7	-3.7	-3.2	-0.6	1.3	0.7	-3.0
Past tobacco smoking	3.0	5.5	9.2	-2.3	-3.0	-2.8	-2.1	-1.4	-1.8	-2.6
Basal cell carcinoma (self-reported)	3.0	3.6	9.1	-0.4	3.0	2.7	1.0	-0.7	-0.9	2.4
Deep venous thrombosis (DVT) (self-reported)	3.0	3.9	13.2	1.0	3.6	1.7	0.7	1.3	2.1	1.8
Average weekly fortified wine intake	2.9	3.4	8.4	1.2	2.9	1.8	1.4	1.2	0.9	2.5
Maternal smoking around birth	2.9	4.2	10.9	2.5	3.3	1.7	1.8	0.6	0.2	2.3
Hayfever, allergic rhinitis or eczema	2.9	6.3	8.7	2.5	1.7	2.6	2.7	-2.6	-2.4	3.0
Qualifications: O levels/GCSEs or equivalent	2.9	4.6	13.6	2.7	1.6	1.0	3.7	-0.8	-0.8	2.5
Ever had bowel cancer screening	2.9	3.4	10.6	0.3	0.7	-1.4	0.6	3.2	3.3	-0.0
Arm fat percentage (right)	2.8	11.0	21.0	-1.8	-3.0	-4.6	-2.9	3.2	2.8	-4.2
Length of working week for main job	2.8	3.1	11.1	-1.0	0.3	-0.9	-0.6	3.3	2.9	-0.5
Medication: Aspirin	2.8	3.7	6.1	-1.6	-1.7	-1.5	-2.2	2.0	1.8	-2.5
Medication: Gliclazide	2.8	3.1	8.7	-0.4	-3.0	-0.8	-2.7	0.7	0.5	-2.1
BMI	2.7	15.8	25.8	-1.6	-1.7	-5.1	-4.2	4.9	4.8	-3.9
Body mass index (BMI)	2.7	11.4	26.6	-0.5	-0.5	-4.4	-2.3	5.2	4.8	-2.2
Medication: Atenolol	2.6	3.2	9.7	-0.7	0.5	-1.9	0.0	2.8	3.1	-1.0
Heart attack	2.6	3.3	11.4	-0.7	-0.3	-0.3	-0.3	3.4	3.3	-0.2
Trunk fat-free mass	2.6	14.9	39.4	1.6	3.8	-0.9	1.4	6.3	6.0	3.1
Trunk predicted mass	2.6	14.7	39.6	1.5	3.7	-0.9	1.4	6.3	6.0	3.0
Blood clot in the leg (DVT)	2.6	3.3	12.1	0.7	3.5	1.7	0.6	1.0	2.0	1.7
Ever had prostate specific antigen (PSA) test	2.6	3.0	11.3	-0.6	-0.0	-1.3	0.6	3.4	2.6	0.2
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	7.6	1.7	2.0	1.5	2.8	-0.3	0.0	2.3
Schizophrenia (2018)	2.5	5.3	17.1	-0.0	0.4	1.8	0.9	-3.8	-4.1	1.0
Supplements: Zinc	2.4	2.6	4.2	1.9	1.2	2.1	1.4	-1.2	-1.1	2.0
Arm fat-free mass (right)	2.4	12.4	28.7	1.7	4.2	-0.6	1.1	5.4	5.2	3.1
Knee pain experienced in last month	2.4	3.8	9.1	-1.7	-1.1	-1.4	-3.0	2.0	1.6	-2.2
Arm fat percentage (left)	2.4	9.4	17.7	-1.7	-2.5	-4.2	-2.8	3.0	2.5	-4.0
Eye problems/disorders: Glaucoma	2.4	2.8	5.5	0.1	0.7	2.3	1.6	-2.2	-1.9	1.7
Medication: Blood pressure	2.4	4.5	12.7	-1.3	0.2	-1.6	-0.9	3.4	3.6	-1.4
Heart attack/myocardial infarction (self-reported)	2.4	3.1	11.0	-0.6	-0.3	-0.5	-0.4	3.3	3.2	-0.3
Leg fat-free mass (left)	2.3	12.1	35.4	-0.2	1.1	-3.7	-1.4	6.0	5.7	-0.2
Leg predicted mass (left)	2.3	12.2	35.2	-0.2	1.1	-3.8	-1.4	5.9	5.7	-0.2
Waist circumference	2.3	8.3	21.4	-0.6	-0.6	-3.2	-1.5	4.6	4.5	-1.9
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	6.4	1.4	2.5	2.0	1.2	0.6	1.1	1.7
Whole body fat-free mass	2.3	13.3	39.1	1.0	3.0	-2.0	0.3	6.2	6.0	1.9
Whole body water mass	2.3	12.9	37.9	1.0	3.0	-2.0	0.2	6.2	5.9	1.9
Body Mass Index (BMI) (2010)	2.2	3.0	8.9	0.3	0.9	-1.6	-0.8	2.8	3.0	-0.0
Lung FVC	2.2	11.3	28.2	-4.5	-2.5	-1.9	-5.3	1.2	0.8	-4.2
Pack years adult smoking proportion	2.2	3.3	10.3	1.1	-1.3	-0.8	-0.8	-3.2	-3.0	-0.1
Father’s age at death	2.2	2.9	5.8	2.0	0.9	0.1	1.4	-2.4	-2.1	1.8
Arm fat mass (right)	2.2	9.0	16.8	-1.3	-1.3	-4.0	-2.4	4.1	3.7	-2.8
Exposure to tobacco smoke outside home	2.2	3.0	8.3	-1.3	-2.9	-1.5	-1.9	-0.2	-0.9	-2.0
Arm predicted mass (right)	2.2	11.5	27.0	1.6	4.0	-0.9	1.1	5.2	5.0	2.9
Leg fat-free mass (right)	2.2	11.7	33.9	0.0	1.2	-3.6	-1.5	5.8	5.6	-0.0
Medication for cholesterol	2.2	3.3	8.8	1.0	0.9	1.4	0.3	-3.0	-2.8	1.5
Leg predicted mass (right)	2.2	11.8	34.0	-0.1	1.2	-3.6	-1.6	5.8	5.6	-0.2
Arm fat-free mass (left)	2.2	10.9	30.2	1.3	3.1	-1.5	0.7	5.5	5.2	2.3
Schizophrenia vs Biploar Disorder	2.1	2.7	8.3	0.5	-2.1	-0.3	1.1	-2.2	-2.9	0.3
Cardiovascular Disease	2.1	6.8	10.9	-2.9	-1.4	-2.4	-2.0	3.3	2.8	-3.0
Relative age of first facial hair	2.1	4.3	14.2	1.0	-0.4	0.7	0.2	-3.8	-3.8	0.1
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	7.7	-0.1	-0.3	0.7	-1.7	-2.7	-2.8	-0.6
Headache pain in last month	2.1	3.6	10.1	-1.7	-1.1	0.6	-1.2	-3.2	-3.1	-0.6
Guilty feelings	2.1	3.2	7.5	-0.5	0.1	-2.7	1.5	2.7	2.2	-0.6
Basal metabolic rate	2.1	11.4	34.8	0.8	2.4	-2.3	0.1	5.9	5.6	1.4
Pack years of smoking	2.1	3.1	9.5	1.2	-1.5	-0.5	-0.7	-3.1	-2.8	-0.2
Breast Cancer	2.0	4.7	12.3	1.4	0.2	3.5	2.9	-1.7	-1.8	2.1
Medication: Co-codamol	2.0	2.3	5.2	2.3	2.1	0.7	1.4	-0.6	-0.6	1.7
Medication: Lansoprazole	2.0	2.3	6.8	-0.9	1.1	0.9	-0.9	2.6	2.3	-0.1
Birth weight of first child	2.0	3.7	9.9	-0.6	-2.3	0.2	-1.0	-3.1	-2.6	-1.5
Shortness of breath walking on level ground	2.0	2.4	7.0	0.9	1.1	-0.8	0.9	2.4	2.6	0.6
Arm predicted mass (left)	2.0	10.2	27.0	1.2	3.2	-1.2	0.7	5.2	5.0	2.3
Allergy	1.9	4.4	8.2	-2.1	-2.4	-2.3	-2.6	0.5	0.3	-2.9
Medication: Ramipril	1.9	2.4	6.5	-1.2	-0.2	0.7	-1.7	2.1	2.5	-1.1
Arm fat mass (left)	1.9	7.6	15.7	-0.9	-0.9	-3.6	-2.0	4.0	3.6	-2.4
Bipolar Disorder or Schizophrenia	1.8	4.4	14.2	-0.8	0.6	1.9	-0.0	-3.5	-3.8	0.4
Depression (Nagel 2018)	1.8	2.7	8.1	-1.9	0.0	-1.2	-0.5	2.8	2.4	-0.4
Angina	1.8	2.4	7.2	-0.9	-1.1	0.5	-0.5	2.2	2.7	-1.5
Vitamin and mineral supplements	1.8	2.5	6.3	-0.9	0.3	-2.2	0.5	2.2	2.5	-0.6
Diabetes (father)	1.8	2.3	7.9	0.5	-1.0	0.9	0.1	-2.8	-2.4	-0.5
Age when periods started (menarche)	1.8	4.4	9.7	1.6	0.5	3.1	1.8	-2.3	-2.6	1.8
Medication: Amlodipine	1.8	2.5	8.5	0.3	0.4	-1.8	-0.4	2.9	2.3	0.0
Number of full brothers	1.8	2.2	6.0	-1.2	-1.5	1.2	-0.5	-1.9	-2.4	-0.6
Smoking status: Previous	1.8	2.6	5.7	1.3	1.7	1.7	1.1	1.8	2.4	0.9
Respiratory disease	1.7	3.8	11.8	1.5	1.2	-0.2	0.2	3.4	3.3	0.3
Average weekly spirits intake	1.7	2.2	6.9	0.9	1.2	-0.1	0.4	2.6	2.0	1.4
Taking other prescription medications	1.7	2.6	8.2	1.3	0.6	-0.6	0.9	2.7	2.9	0.1
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	5.4	-1.5	-0.7	-2.2	-1.1	2.3	1.8	-0.8
Had other major operations	1.7	2.1	3.4	0.2	1.7	1.8	0.3	1.8	1.7	1.5
Neuroticism score	1.7	3.5	6.6	-2.6	-2.0	-2.2	-1.1	1.3	0.9	-2.2
Weight	1.7	8.3	26.4	0.0	0.6	-2.9	-0.8	5.1	4.7	-0.2
Worrier / anxious feelings	1.7	3.3	10.0	-3.2	-2.0	-1.6	-1.0	-0.4	-0.5	-2.2
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	9.4	1.1	0.2	1.2	0.1	-3.1	-2.6	0.9
Medication: Blood pressure	1.7	3.0	7.8	-1.4	-0.8	-1.6	-0.8	2.8	2.4	-1.5
Angina (self-reported)	1.7	2.2	7.3	-0.5	-0.8	0.5	-0.3	2.3	2.7	-1.1
Leg pain on walking	1.7	2.1	5.5	-1.6	-1.6	-0.2	-2.4	-0.4	-1.0	-1.7
Ovarian Cancer	1.6	2.1	5.9	1.7	1.5	-0.4	2.4	-0.0	-0.3	1.8
Neuroticism	1.6	3.8	8.1	-2.6	-2.0	-2.8	-0.4	1.2	0.7	-2.4
Relative age voice broke	1.6	2.4	5.3	2.3	1.2	1.1	0.4	-1.9	-1.7	1.5
Hearing difficulty/problems with background noise	1.6	2.5	13.4	0.3	1.1	-0.5	3.7	0.8	0.5	1.4
Tense / ‘highly strung’	1.6	2.6	8.4	-2.9	-1.1	-2.3	-1.0	0.7	0.4	-1.2
Gout (self-reported)	1.6	2.3	3.8	-1.2	-1.9	-0.7	-2.0	1.1	1.1	-2.0
Wheeze or whistling in the chest in last year	1.6	2.8	8.0	0.6	1.8	-0.3	0.8	2.8	2.4	1.2
Migraine (self-reported)	1.6	1.9	5.4	-0.2	-1.7	0.8	-0.7	-2.3	-1.9	-0.7
Commuting to job workplace: Walk	1.6	1.7	5.9	0.0	0.1	0.0	-0.2	-2.4	-2.4	0.5
Ever taken oral contraceptive pill	1.6	1.8	4.3	-2.1	-1.2	1.0	-1.1	-1.5	-1.2	-1.1
Ulcerative Colitis	1.5	2.2	10.8	-0.0	3.3	0.0	1.4	0.1	0.4	1.7
Waist Hip Ratio (WHR)	1.5	6.9	18.0	-1.1	-1.2	-1.2	-2.0	3.6	4.2	-3.0
Diabetes (mother)	1.5	2.0	6.7	-1.5	-0.9	-0.8	-2.6	-0.8	-0.7	-1.5
Exposure to tobacco smoke at home	1.5	1.7	4.0	-0.4	-0.6	-1.6	-0.2	1.8	2.0	-1.1
Medication: Paracetamol	1.5	2.4	6.7	0.6	0.2	1.5	1.5	-2.6	-2.2	0.5
Health satisfaction	1.5	1.9	4.9	-0.9	-0.4	-0.6	-0.4	2.0	2.2	-1.7
Mother’s age at death	1.5	1.8	4.5	0.0	-1.1	0.7	-1.5	-2.1	-2.0	0.5
Number of operations (self-reported)	1.5	2.3	9.1	-0.1	-0.2	-0.2	-0.9	2.3	3.0	-0.9
Supplements: Glucosamine	1.4	1.9	4.0	-1.0	-0.7	0.0	-1.6	1.7	2.0	-1.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	3.5	1.6	1.7	0.9	1.9	-1.2	-0.5	1.4
Qualifications: A levels/AS levels or equivalent	1.4	3.1	8.4	0.7	0.6	1.7	1.6	-2.9	-2.3	1.6
Worry too long after embarrassment	1.4	2.4	6.5	-2.1	-0.8	-2.5	0.2	1.6	0.6	-1.6
Medication: Ibuprofen	1.4	1.7	5.2	0.3	-0.5	0.4	-1.3	-2.0	-2.3	-0.5
Medication: Omeprazole	1.4	1.7	3.6	1.5	1.3	1.4	1.9	-0.4	0.1	1.3
Heart disease (mother)	1.4	1.7	4.0	0.4	0.0	0.6	1.8	2.0	2.0	0.6
Commuting to job workplace: Car/motor vehicle	1.4	1.6	6.8	0.2	-2.6	-0.3	-0.8	0.8	0.8	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	6.4	0.4	0.4	-0.0	-0.2	2.5	2.1	0.6
Osteoporosis (self-reported)	1.4	1.8	2.7	-0.6	-1.6	-1.0	-1.6	-1.2	-1.4	-1.6
Number of self-reported non-cancer illnesses	1.4	2.4	9.1	0.1	1.4	-0.1	0.7	2.4	3.0	-0.2
Reaction Time	1.3	2.4	5.0	-1.8	-0.2	1.5	-2.2	-1.9	-0.7	-1.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.6	-1.9	-0.3	0.4	-1.7	-1.0	-0.3	-1.6
Hand grip strength (left)	1.3	3.3	5.1	-2.3	-1.8	-1.5	-1.3	2.0	1.6	-2.1
Stomach or abdominal pain in last month	1.3	1.6	4.4	-0.2	1.3	0.6	0.2	2.1	2.0	0.9
Asthma	1.3	2.6	8.1	1.0	1.4	0.2	0.4	2.8	2.5	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.1	6.4	0.9	1.2	-0.8	0.8	1.7	2.5	1.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	5.4	0.8	2.3	0.3	1.1	1.1	0.9	1.1
Eye problems/disorders: None of the above	1.3	1.5	3.8	-0.6	-1.5	-1.9	-0.4	1.1	0.6	-1.7
Back pain experienced in last month	1.3	2.0	5.5	2.3	1.8	1.7	0.7	-0.3	0.2	1.2
Risk taking	1.3	1.9	5.0	-0.9	0.7	2.2	-0.9	-1.8	-1.5	0.7
Heart disease (siblings)	1.3	1.6	5.4	-0.9	0.3	-0.1	-0.3	1.9	2.3	-1.1
LDL Cholesterol	1.2	2.0	7.5	-0.8	-0.8	-0.6	0.5	-2.1	-2.7	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	4.9	-0.7	0.6	-1.2	-0.5	2.2	1.8	0.2
Medication: Simvastatin	1.2	1.7	6.4	-0.1	0.8	-0.9	0.6	2.5	1.9	-0.1
Happiness	1.2	1.4	3.1	0.5	-0.4	1.3	1.8	-1.4	-1.7	0.6
Illnesses of father: None of the above (group 1)	1.2	1.5	5.9	0.9	-0.2	0.5	0.3	-1.7	-2.4	0.7
Hearing difficulty/problems: Yes	1.1	1.6	8.4	0.0	-0.3	-1.4	2.9	0.8	0.4	0.4
Trunk fat percentage	1.1	4.3	9.0	-1.7	-2.4	-2.7	-1.9	1.0	0.5	-3.0
Had menopause	1.1	1.4	3.5	-1.1	-0.8	-1.9	-1.3	-1.2	-0.8	-0.9
Diabetes (self-reported)	1.1	1.7	4.8	-0.3	-1.6	-0.9	-1.5	0.4	1.2	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	13.2	-3.6	-0.8	-0.0	-2.3	-0.7	-1.0	-1.8
Breastfed as a baby	1.1	1.4	2.6	-0.8	-1.4	0.3	-1.6	0.9	1.3	-1.4
Emphysema/chronic bronchitis	1.1	1.3	2.8	1.3	0.6	-1.6	0.0	0.8	1.7	-1.1
Family relationship satisfaction	1.1	1.3	3.9	-0.0	0.3	0.8	0.9	-2.0	-1.9	-0.1
Mood swings	1.1	2.0	7.0	-2.0	-2.6	-0.9	-0.4	0.2	0.2	-1.4
Medication: Lisinopril	1.1	1.4	2.7	-0.4	1.3	-1.3	1.5	1.6	1.2	0.4
Depressed Affect (Nagel 2018)	1.0	2.1	5.7	-1.5	-2.4	-1.8	0.4	1.4	0.8	-1.0
Irritable Bowel Disease (IBD)	1.0	2.3	10.6	-0.3	3.3	0.1	0.7	-1.1	-0.9	1.7
Fasting Glucose	1.0	1.2	4.9	0.0	0.4	-0.0	0.5	-2.2	-1.8	0.4
Neuroticism (2016)	1.0	1.5	3.2	-1.0	-1.7	-1.8	1.3	0.7	0.1	-1.0
Frequency of depressed mood in last 2 weeks	1.0	1.3	4.2	-0.6	0.2	-1.3	-0.6	2.0	1.7	0.1
Medication for hormone replacement therapy	1.0	1.2	3.8	-0.9	-1.8	-0.4	-0.3	-0.2	-0.1	-2.0
Medication: Cholesterol lowering	1.0	1.6	5.4	0.3	0.1	0.4	1.0	2.3	2.1	0.2
Pulse wave reflection index	1.0	1.3	3.9	0.3	-0.1	0.6	1.1	-1.6	-2.0	0.9
Mean time to correctly identify matches	1.0	1.9	4.1	-1.5	-0.4	1.5	-2.0	-1.4	-0.2	-1.6
Whole body fat mass	1.0	4.4	8.7	-1.0	-1.1	-2.9	-1.4	2.9	2.5	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.9	-1.0	-0.6	0.4	-1.3	-1.3	-1.0	-1.7
Supplements: Vitamin C	1.0	1.2	4.0	0.4	0.6	2.0	-0.3	-1.3	-1.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.3	-0.2	1.3	0.0	1.0	1.5	1.5	0.5
Qualifications: nursing, teaching	1.0	1.6	3.1	-0.0	1.3	1.3	0.9	-1.8	-1.5	1.1
Commuting to job workplace: Public transport	1.0	1.1	2.0	0.7	1.4	0.3	1.1	-1.3	-0.9	1.4
Supplements: Fish oil (including cod liver oil)	1.0	1.2	2.4	-1.1	-1.2	-0.1	-1.1	-1.3	-1.5	-0.8
Medication: Bendroflumethiazide	1.0	1.5	4.2	-0.7	-1.2	-0.6	-0.9	2.0	1.3	-1.3
Alcohol drinker status: Never	1.0	1.1	3.3	-1.1	-0.6	-0.5	-1.8	-1.0	-1.0	-1.0
Number of treatments/medications taken	0.9	1.7	4.5	-0.3	-1.0	-1.0	-0.5	2.1	1.8	-1.2
Ever had hysterectomy (womb removed)	0.9	1.0	1.8	0.2	0.6	-1.1	1.0	1.3	1.3	0.9
Severe depression (siblings)	0.9	1.0	2.1	1.4	1.4	0.5	0.9	0.2	0.3	1.3
Trunk fat mass	0.9	3.8	6.9	-1.1	-1.3	-2.6	-1.3	2.6	2.1	-1.9
Alcohol usually taken with meals	0.9	1.4	4.5	-0.5	1.3	0.1	0.7	1.3	2.1	1.1
Alcohol intake versus 10 years previously	0.9	1.4	4.7	-1.1	-0.9	-0.2	-2.2	-0.4	0.4	-1.6
Depression (self-reported)	0.9	1.1	2.7	1.0	1.4	-0.2	-0.5	0.8	1.6	1.0
Prospective memory result	0.9	1.1	3.3	-0.4	-0.7	-1.0	-1.8	-0.9	-0.9	-1.0
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.5	-0.6	0.3	1.1	0.5	1.9	1.5	-0.2
Body fat percentage	0.9	3.6	7.1	-1.4	-2.1	-2.6	-1.6	1.3	0.8	-2.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	4.1	-2.0	-0.5	-0.0	0.2	-1.0	-0.9	-0.9
Age at last live birth	0.9	1.3	3.6	0.4	1.9	1.6	0.6	-0.3	-0.2	1.4
Long-standing illness, disability or infirmity	0.9	1.4	4.3	0.5	-0.4	-0.2	-0.8	2.1	2.0	-0.3
Asthma (self-reported)	0.9	1.8	5.4	1.0	1.3	0.7	0.3	2.3	2.0	0.4
Age started oral contraceptive pill	0.9	1.2	3.5	-0.8	-1.1	-0.1	-0.3	-1.9	-1.6	-0.3
Commuting to job workplace: Cycle	0.9	1.1	2.4	1.6	1.0	0.7	0.8	0.8	1.2	1.0
Supplements: Calcium	0.9	1.0	1.5	0.9	0.5	1.2	-1.1	-1.2	-1.2	0.1
Leg fat mass (left)	0.9	3.5	10.6	-0.2	-0.3	-2.3	-0.6	3.3	2.7	-0.7
Ulcerative Colitis (UC)	0.8	1.5	8.0	-0.8	2.8	0.1	0.5	-0.5	-0.2	1.1
Major Depression (MDD)	0.8	1.0	3.0	1.1	0.7	-0.7	1.7	0.2	0.7	1.0
HDL Cholesterol	0.8	1.4	4.0	0.1	-0.2	0.1	1.5	-1.6	-2.0	0.8
Triglycerides	0.8	1.2	2.6	-0.6	-1.0	-0.6	-1.6	-1.4	-1.0	-1.2
Townsend deprivation index at recruitment	0.8	1.1	2.3	1.1	0.4	0.4	0.6	-1.5	-1.2	1.4
Serious illness, injury or assault to yourself	0.8	1.0	2.1	-0.5	-0.2	-0.8	-1.2	1.1	1.4	-1.2
Multivitamins +/- minerals	0.8	1.0	3.5	0.4	-0.3	1.9	-0.6	-1.0	-1.4	0.3
Number of incorrect matches in round	0.8	1.3	2.9	-0.5	-1.0	1.7	-1.3	-1.1	-1.3	-0.3
Forced vital capacity (FVC)	0.8	3.1	8.9	-3.0	-0.2	-0.5	-2.2	1.8	1.5	-1.5
Hair/balding pattern: Pattern 3	0.8	1.2	3.6	-1.4	0.2	0.8	0.4	1.9	1.3	-0.5
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	9.9	-3.1	-0.8	-0.4	-2.2	-0.5	-1.0	-1.4
Loud music exposure frequency	0.8	0.9	2.4	-1.4	-0.3	0.2	0.2	-1.1	-1.6	-0.7
Forced vital capacity (FVC), Best measure	0.8	2.9	11.8	-3.4	-0.2	0.0	-1.8	1.2	1.0	-1.6
Leg fat mass (right)	0.8	3.2	9.7	-0.2	-0.3	-2.2	-0.5	3.1	2.6	-0.7
Alcohol intake frequency.	0.8	1.8	3.7	-1.1	-0.5	0.2	-1.9	-1.9	-1.4	-1.3
Average weekly champagne plus white wine intake	0.8	1.1	4.0	-0.1	0.3	0.0	0.6	2.0	1.8	0.5
Illnesses of father: High blood pressure	0.8	1.0	2.2	-0.9	-1.0	-1.0	0.4	0.9	1.0	-1.5
Alzheimer’s Disease (including proxy)	0.7	1.1	3.4	0.1	-1.3	-1.8	-1.3	-0.1	0.4	-0.8
Age at First Birth	0.7	1.1	3.6	0.8	-0.7	0.3	0.2	-1.9	-1.6	-0.0
Blood Red Count	0.7	6.8	20.6	1.6	0.9	0.6	1.6	4.5	4.5	0.6
Hypothyroidism (self reported)	0.7	1.7	4.7	1.0	2.2	-0.8	0.9	1.3	0.9	1.5
Medication: Metformin	0.7	1.0	1.7	1.1	-1.3	0.3	-0.8	-1.3	-0.8	-0.8
Hip circumference	0.7	3.1	9.0	-0.3	-0.7	-3.0	-0.7	2.6	2.1	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.8	0.2	1.4	-1.2	1.1	1.3	0.6	1.1
Number of live births	0.7	1.0	3.1	1.0	0.7	0.1	0.5	1.8	1.3	0.6
Pulse wave Arterial Stiffness index	0.7	0.8	2.4	-1.0	0.0	0.9	-0.4	-1.1	-1.6	-0.2
Pulse wave peak to peak time	0.7	0.9	2.2	1.2	0.4	-0.3	0.9	1.0	1.5	0.7
Diabetes diagnosed by doctor	0.7	1.2	3.9	-0.3	-0.8	-0.2	-2.0	-0.8	-0.1	-1.7
Breast cancer (self-reported)	0.7	0.8	2.1	-0.1	-0.8	-1.4	-0.9	0.0	0.6	-1.4
Alzheimer’s Disease (in father)	0.6	0.7	2.0	0.5	-1.1	-1.0	-1.4	0.1	0.4	-0.1
Crohns Disease (2017)	0.6	1.3	3.7	-0.2	1.9	0.4	0.3	-1.2	-1.3	1.3
Primary Biliary Cirrhosis	0.6	0.9	1.7	1.2	0.9	0.2	1.3	0.4	0.9	1.2
Height	0.6	12.5	32.0	0.5	3.3	4.1	5.7	0.6	0.8	5.2
Hand grip strength (right)	0.6	1.6	4.9	-2.2	-1.7	-0.3	-0.3	0.7	0.6	-1.7
Fed-up feelings	0.6	1.0	2.7	1.4	0.2	-0.3	1.5	0.4	0.1	1.6
Qualifications: CSEs or equivalent	0.6	0.8	1.3	1.2	0.6	1.1	1.0	-1.0	-0.7	0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.3	0.8	1.5	0.1	0.5	0.7	0.5	1.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	-1.4	0.4	-0.7	-1.0	-0.7	-0.4	-0.9
Qualifications: None of the above	0.6	1.4	3.3	-1.1	-1.6	-0.8	-1.8	0.1	-0.3	-1.3
Mouth/teeth dental problems: Dentures	0.6	1.1	2.4	-0.9	-0.6	0.5	-1.6	1.0	1.0	-1.3
Standing height	0.6	5.8	16.0	1.0	2.5	2.7	3.0	0.8	0.8	4.0
Qualifications: College or University degree	0.6	1.9	7.9	-0.5	-0.5	0.2	-1.1	-2.8	-1.8	-0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.1	1.5	0.8	-1.1	-0.2	-0.4	0.8	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	1.9	-0.2	0.9	1.4	0.8	0.6	0.9	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	0.7	0.1	-0.5	1.3	1.2	0.9	-0.1
Number of full sisters	0.6	0.8	1.8	-0.4	1.3	1.3	1.1	0.0	-0.0	0.7
Overall health rating	0.6	1.3	3.0	-1.7	0.5	-0.9	-0.6	1.5	1.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.0	-0.4	0.8	1.7	0.8	-0.7	-1.3	1.7
Loneliness, isolation	0.6	0.9	3.3	-1.0	-1.8	0.1	-0.7	-0.4	-0.5	-1.0
Mineral and other dietary supplements	0.6	0.8	1.7	0.1	1.3	-0.1	1.2	0.9	1.2	0.4
Wears glasses or contact lenses	0.6	0.7	1.9	-1.4	-1.2	-0.2	0.3	0.7	0.5	-0.7
Financial situation satisfaction	0.6	0.8	2.7	-0.3	1.5	1.6	0.4	-0.0	-0.3	0.4
Medication: Paracetamol	0.6	0.9	2.7	-0.6	0.0	0.8	0.7	-1.7	-1.5	-0.2
Myopia	0.6	0.9	2.7	1.6	0.8	-0.5	1.0	0.4	0.4	1.1
Bipolar Disorder (2018)	0.5	0.8	1.6	-1.3	0.4	0.7	-1.1	-0.9	-0.9	-0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.2	-1.2	-1.3	-1.8	-0.5	-0.0	-0.0	-1.6
Mean Putamen Volume	0.5	0.6	1.6	1.3	1.0	-0.3	-0.6	-0.9	-0.2	0.5
Rheumatoid Arthritis	0.5	0.7	1.7	-0.2	-0.6	-1.3	-0.7	1.2	0.7	-0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.0	-0.3	-0.4	1.2	-1.4	-0.5	-0.2	-0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.1	-0.8	1.4	0.7	0.2	0.4	0.5	0.4
Medication: Levothyroxine sodium	0.5	0.8	1.7	-1.1	0.2	-1.3	-0.4	1.1	0.9	-0.6
Fluid intelligence score	0.5	0.9	2.5	-0.2	-0.8	-1.5	1.6	0.9	0.5	-0.3
Medication: Allopurinol	0.5	0.7	1.2	-0.6	-1.1	-0.6	-0.9	1.0	0.7	-0.8
Chest pain or discomfort	0.5	0.7	1.9	0.1	0.4	-0.9	0.8	1.0	1.4	-0.6
Average weekly red wine intake	0.5	0.8	2.1	-1.5	-0.6	-1.1	0.4	0.7	0.9	-0.6
Friendships satisfaction	0.5	0.7	1.7	-1.3	-0.8	0.4	0.4	-0.9	-1.0	-0.4
Miserableness	0.5	0.8	3.5	-0.2	-0.8	-1.9	0.8	0.8	0.4	-0.2
Hearing aid user	0.5	0.5	1.6	1.0	-0.9	-0.3	1.3	-0.0	-0.1	0.5
Irritability	0.5	0.8	2.6	1.4	0.6	0.6	0.4	0.3	0.7	1.6
Alzheimer’s Disease (in mother)	0.4	0.5	1.6	-0.7	0.4	-1.2	-0.6	0.4	0.8	-0.3
Bipolar Disorder (2011)	0.4	0.4	1.2	0.0	0.0	0.0	0.0	-1.1	-0.5	-1.0
Sensitivity / hurt feelings	0.4	0.7	2.4	-1.5	-0.6	-0.4	0.8	-0.1	-0.3	-0.9
Financial difficulties in last 2 years	0.4	0.5	1.6	-1.3	-0.0	-0.0	-0.1	-0.2	-1.2	-0.6
Mouth/teeth dental problems	0.4	0.6	2.4	-0.3	-0.0	0.1	1.5	-0.4	-1.1	0.7
Pain all over the body in last month	0.4	0.5	1.7	-0.9	-0.2	-0.2	-0.8	-0.0	-0.3	-1.3
Lung cancer (father)	0.4	0.5	2.0	0.8	0.2	1.4	-0.0	-0.2	-0.4	0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	-0.8	0.6	-0.8	-0.9	0.2	0.9	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.0	0.0	1.3	-0.9	0.1	1.4	0.8	0.7
Number of children fathered	0.4	0.4	0.9	0.8	-0.9	0.1	-0.0	0.8	0.7	-0.4
Medication for pain relief, constipation, heartburn	0.4	0.7	1.7	0.6	0.2	-1.0	0.1	1.3	1.3	0.5
Neck or shoulder pain in last month	0.4	0.6	1.5	-1.2	0.5	0.3	-0.3	1.1	1.0	-0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.5	0.5	-0.7	-1.2	0.9	0.5	0.3	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.6	-1.2	0.5	0.6	0.3	-0.6	-0.7	-0.1
Eye problems/disorders: Cataract	0.4	0.5	1.6	-0.3	1.3	-0.4	-0.6	0.9	0.7	0.4
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.3	-0.6	0.2	-0.5	0.3	1.2	0.4	0.8
Medication: Atorvastatin	0.4	0.5	1.2	0.6	-0.8	0.5	-0.1	-1.1	-1.0	0.1
Average weekly beer plus cider intake	0.4	0.6	2.1	0.3	-0.2	-1.3	-1.5	0.7	0.2	-0.4
Fractured/broken bones in last 5 years	0.4	0.5	1.3	-0.9	-0.1	-1.1	-0.6	-0.5	-0.6	-0.8
Cholesterol lowering medication	0.4	0.6	2.3	-0.7	-0.1	-0.3	0.2	1.5	1.2	-0.4
Crohns Disease (2012)	0.3	0.4	2.2	0.3	1.5	0.4	0.4	0.3	-0.0	0.6
Lupus	0.3	0.5	1.5	0.0	0.5	1.0	0.1	-1.2	-1.0	-0.1
Tanning	0.3	3.2	9.3	-1.6	-3.0	-0.4	-2.3	-1.1	-1.5	-1.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.1	1.0	0.9	0.3	-0.1	-0.4	-0.2	0.6
Sitting height	0.3	1.8	8.2	-2.9	-1.7	0.1	-0.7	-0.4	-0.8	-0.8
Time employed in main current job	0.3	0.4	0.8	0.5	0.5	0.4	-0.6	0.9	0.9	0.3
Pulse rate	0.3	0.4	2.0	-1.4	0.6	0.8	0.2	0.2	0.2	-0.1
Noisy workplace	0.3	0.3	1.2	-0.6	-0.4	-0.2	-0.5	0.2	0.4	-1.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	-0.1	0.7	-0.7	0.6	0.2	-0.1	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.1	-1.2	-0.8	-0.4	0.1	0.4	-0.9
Comparative height size at age 10	0.3	1.5	5.5	-0.5	0.9	0.5	0.6	1.5	2.4	1.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	-0.8	0.3	-0.0	-0.5	-0.9	-0.2	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.2	1.0	-0.5	-1.1	-0.2	-0.6	-0.2	-0.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-0.0	0.8	0.3	-0.1	-1.1	-0.8	-0.2
Alcohol drinker status: Previous	0.3	0.4	0.6	-0.7	-0.1	-0.7	-0.6	0.6	0.6	-0.8
HbA1C	0.2	0.2	0.8	0.1	-0.2	0.1	-0.6	-0.9	-0.3	-0.1
Blood Eosinophil Count	0.2	1.7	4.3	-1.2	-0.7	0.9	-1.8	-1.3	-0.4	-2.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	0.8	0.0	0.3	0.5	-0.6	-0.5	0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.1	-0.7	-0.4	-0.7	0.4	0.1	-0.5
High blood pressure (mother)	0.2	0.3	0.9	0.1	-1.0	0.4	-0.7	-0.3	-0.2	-0.8
Illnesses of mother	0.2	0.2	0.7	-0.2	-0.1	-0.2	0.3	-0.4	-0.9	0.5
Leg fat percentage (left)	0.2	0.7	2.2	0.2	-0.7	-1.0	-0.1	1.5	0.8	-0.6
Ever depressed for a whole week	0.2	0.2	0.6	-0.4	0.7	-0.8	-0.0	0.1	0.3	0.1
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.8	0.1	0.3	0.2	0.8	0.2	0.3
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.7	-0.5	-0.3	-0.8	0.6	-0.2	-0.3	0.0
Prostate Cancer	0.1	0.1	0.6	-0.0	-0.0	0.8	-0.2	-0.1	0.3	-0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.7	0.2	0.2	-0.7	-0.5	0.2	-0.5
Chronotype (morning person)	0.1	0.3	0.8	0.8	-0.5	0.2	0.9	0.5	0.2	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.3	0.5	0.0	0.5	0.1	0.3	0.6
Falls in the last year	0.1	0.2	0.7	-0.4	0.1	-0.1	0.2	0.7	0.9	-0.1
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.5	-0.6	-0.3	-0.4	-0.1	-0.5	-0.1
Leg fat percentage (right)	0.1	0.5	1.6	0.1	-0.7	-1.0	0.2	1.2	0.6	-0.5
Age at first live birth	0.1	0.2	0.4	-0.7	0.7	0.5	0.4	0.1	0.3	0.3
Pulse rate, automated reading	0.1	0.5	1.0	-0.9	1.0	-0.3	-0.3	0.9	0.6	-0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.4	0.6	0.0	0.4	0.0	-0.3	-0.1	0.1
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.4	0.4	0.4	0.7	-0.2	-0.2	0.2
Pain experienced in last month	0.1	0.2	0.7	0.4	-0.4	0.2	0.8	-0.2	-0.3	0.4
Hair Pigment	0.0	1.1	3.9	1.1	0.6	0.4	0.4	1.3	2.0	-0.6

Hub : Genes

SMG6

Models

Trait associations