Best TWAS P=2.54e-10 · Best GWAS P=4.08e-09 conditioned to 0.000667
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | RABEP1 | 0.13 | 0.03 | lasso | 13 | 0.02 | 7.2e-02 | -4.0 | -5.2 | 1.7e-07 | -0.80 | 0.04 | 0.83 | FALSE |
2 | GTEx | Brain Putamen basal ganglia | AC012146.7 | 0.30 | 0.03 | enet | 23 | 0.03 | 7.6e-02 | 4.8 | -6.3 | 2.5e-10 | -0.45 | 0.08 | 0.28 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | GP1BA | 0.22 | 0.10 | enet | 9 | 0.18 | 3.1e-13 | 5.7 | 5.1 | 2.9e-07 | 0.26 | 0.03 | 0.97 | FALSE |
4 | GTEx | Colon Sigmoid | GP1BA | 0.25 | 0.17 | lasso | 4 | 0.12 | 3.6e-05 | 5.0 | 5.2 | 2.5e-07 | 0.28 | 0.18 | 0.34 | FALSE |
5 | GTEx | Esophagus Gastroesophageal Junction | DHX33 | 0.12 | 0.08 | lasso | 5 | 0.07 | 1.8e-03 | 5.8 | -5.6 | 1.8e-08 | -0.96 | 0.02 | 0.96 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | RABEP1 | 0.19 | -0.01 | lasso | 13 | 0.00 | 4.2e-01 | 4.6 | -5.3 | 9.3e-08 | -0.82 | 0.04 | 0.79 | FALSE |
7 | GTEx | Esophagus Gastroesophageal Junction | GP1BA | 0.35 | 0.16 | lasso | 11 | 0.18 | 5.9e-07 | 4.5 | 6.0 | 2.0e-09 | 0.56 | 0.16 | 0.74 | FALSE |
8 | GTEx | Esophagus Muscularis | RABEP1 | 0.13 | 0.09 | lasso | 10 | 0.10 | 2.1e-06 | 5.8 | -5.5 | 3.7e-08 | -0.94 | 0.02 | 0.98 | FALSE |
9 | GTEx | Lung | CAMTA2 | 0.10 | 0.02 | lasso | 3 | 0.02 | 1.2e-02 | 4.1 | 5.2 | 2.2e-07 | 0.36 | 0.28 | 0.23 | FALSE |
10 | GTEx | Whole Blood | RP5-1050D4.2 | 0.05 | 0.02 | enet | 11 | 0.04 | 3.1e-04 | 4.9 | 5.2 | 1.7e-07 | 0.37 | 0.35 | 0.54 | FALSE |
11 | NTR | Blood | MINK1 | 0.11 | 0.15 | lasso | 3 | 0.15 | 2.1e-46 | 5.7 | 5.4 | 6.4e-08 | 0.24 | 0.01 | 0.99 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | RABEP1 | 0.20 | 0.22 | bslmm | 546 | 0.20 | 7.4e-25 | 4.6 | -5.5 | 3.6e-08 | -0.75 | 0.75 | 0.25 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | RPAIN | 0.06 | 0.06 | lasso | 3 | 0.06 | 3.1e-08 | 5.9 | -6.1 | 1.3e-09 | -0.98 | 0.00 | 1.00 | FALSE |
14 | ROSMAP | Brain Pre-frontal Cortex | MINK1 | 0.08 | 0.06 | lasso | 3 | 0.05 | 4.0e-07 | 5.3 | 5.3 | 1.3e-07 | 0.31 | 0.10 | 0.89 | FALSE |
15 | The Cancer Genome Atlas | Glioblastoma Multiforme | RABEP1 | 0.23 | 0.13 | blup | 79 | 0.15 | 3.4e-05 | 4.7 | -5.7 | 9.9e-09 | -0.77 | 0.06 | 0.85 | FALSE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C17orf107 | 0.03 | 0.01 | enet | 8 | 0.03 | 5.1e-04 | 2.6 | 5.5 | 3.8e-08 | 0.19 | 0.01 | 0.68 | FALSE |
17 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C17orf107 | 0.10 | 0.03 | blup | 40 | 0.05 | 3.9e-03 | 4.0 | 5.2 | 2.0e-07 | 0.31 | 0.03 | 0.85 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GP1BA | 0.02 | 0.02 | blup | 49 | 0.02 | 9.3e-03 | 4.9 | 5.8 | 5.9e-09 | 0.33 | 0.01 | 0.79 | FALSE |
19 | The Cancer Genome Atlas | Soft Tissue Sarcoma | INCA1 | 0.06 | 0.00 | enet | 11 | 0.00 | 1.7e-01 | 4.5 | 5.5 | 3.7e-08 | 0.30 | 0.01 | 0.73 | FALSE |
20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C17orf107 | 0.05 | 0.01 | blup | 40 | 0.03 | 2.0e-03 | 5.7 | 5.5 | 4.9e-08 | 0.31 | 0.00 | 0.96 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | RABEP1 | 0.04 | 0.03 | enet | 5 | 0.03 | 1.5e-03 | -4.3 | -5.3 | 8.7e-08 | -0.67 | 0.09 | 0.82 | FALSE |