Best TWAS P=7.17e-10 · Best GWAS P=2.37e-10 conditioned to 0.0329
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DPY19L3 | 0.07 | 0.05 | lasso | 2 | 0.06 | 8.7e-08 | -5.0 | -5.1 | 2.9e-07 | 0.01 | 0.02 | 0.97 | FALSE |
2 | GTEx | Esophagus Mucosa | PEPD | 0.37 | 0.32 | enet | 20 | 0.39 | 9.5e-28 | 5.0 | 5.5 | 3.6e-08 | 0.71 | 0.10 | 0.90 | FALSE |
3 | METSIM | Adipose | CHST8 | 0.22 | 0.17 | lasso | 4 | 0.17 | 3.7e-25 | 5.0 | 5.2 | 1.5e-07 | 0.60 | 0.90 | 0.10 | FALSE |
4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PEPD | 0.06 | 0.01 | blup | 114 | 0.04 | 2.6e-04 | 6.0 | 6.0 | 2.5e-09 | 0.84 | 0.02 | 0.94 | FALSE |
5 | The Cancer Genome Atlas | Colon Adenocarcinoma | PEPD | 0.13 | 0.06 | blup | 113 | 0.10 | 1.2e-06 | 4.6 | 6.2 | 7.2e-10 | 0.81 | 0.04 | 0.96 | TRUE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF507 | 0.05 | 0.03 | blup | 39 | 0.05 | 1.3e-06 | -5.3 | -5.4 | 7.3e-08 | -0.02 | 0.00 | 1.00 | TRUE |
7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PEPD | 0.16 | 0.07 | lasso | 3 | 0.05 | 3.1e-03 | 6.0 | 6.0 | 2.4e-09 | 0.79 | 0.04 | 0.85 | FALSE |
8 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF507 | 0.14 | 0.14 | lasso | 5 | 0.18 | 2.4e-17 | -4.8 | -5.4 | 8.4e-08 | -0.01 | 0.01 | 0.99 | FALSE |