Best TWAS P=9.57e-09 · Best GWAS P=2.81e-10 conditioned to 1.58e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CRIPT | 0.12 | 0.10 | lasso | 3 | 0.09 | 7.1e-08 | -5.2 | -5.7 | 9.6e-09 | 0.41 | 0.56 | 0.43 | TRUE |
2 | GTEx | Cells EBV-transformed lymphocytes | CRIPT | 0.28 | 0.16 | enet | 10 | 0.23 | 5.4e-08 | -4.3 | -5.5 | 4.0e-08 | 0.41 | 0.61 | 0.29 | FALSE |
3 | GTEx | Esophagus Muscularis | CRIPT | 0.15 | 0.21 | lasso | 4 | 0.20 | 2.1e-12 | -5.2 | -5.2 | 2.0e-07 | 0.29 | 0.57 | 0.43 | FALSE |
4 | GTEx | Muscle Skeletal | CRIPT | 0.14 | 0.05 | enet | 25 | 0.08 | 1.8e-08 | -4.2 | -5.4 | 7.1e-08 | 0.36 | 0.79 | 0.21 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | PIGF | 0.14 | 0.08 | lasso | 4 | 0.07 | 1.7e-04 | -5.5 | 5.2 | 1.6e-07 | -0.83 | 0.02 | 0.97 | FALSE |
6 | NTR | Blood | CRIPT | 0.04 | 0.05 | lasso | 6 | 0.05 | 3.0e-15 | -5.2 | 5.5 | 5.0e-08 | -0.34 | 0.56 | 0.44 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | CRIPT | 0.36 | 0.31 | enet | 24 | 0.32 | 1.3e-41 | -5.2 | -5.4 | 8.5e-08 | 0.33 | 0.56 | 0.44 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ATP6V1E2 | 0.13 | 0.03 | blup | 76 | 0.04 | 3.8e-09 | -3.5 | 5.3 | 1.1e-07 | -0.36 | 0.02 | 0.17 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | CRIPT | 0.10 | 0.06 | blup | 66 | 0.07 | 5.6e-05 | -4.0 | -5.2 | 2.6e-07 | 0.33 | 0.09 | 0.83 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CRIPT | 0.13 | 0.12 | lasso | 5 | 0.11 | 5.5e-12 | -5.2 | -5.2 | 2.6e-07 | 0.31 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CRIPT | 0.13 | 0.13 | lasso | 3 | 0.15 | 1.2e-15 | -4.9 | -5.3 | 1.0e-07 | 0.37 | 0.01 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | CRIPT | 0.11 | 0.10 | lasso | 4 | 0.11 | 1.6e-10 | -4.3 | -5.2 | 2.2e-07 | 0.32 | 0.02 | 0.97 | FALSE |