Best TWAS P=5.51e-08 · Best GWAS P=1.07e-09 conditioned to 0.00199
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PSMG1 | 0.19 | 0.12 | enet | 26 | 0.13 | 4.1e-11 | -4.9 | 5.2 | 2.2e-07 | 0.72 | 0.54 | 0.46 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | PSMG1 | 0.14 | 0.09 | lasso | 11 | 0.07 | 3.3e-03 | -4.8 | 5.2 | 2.3e-07 | 0.64 | 0.13 | 0.59 | FALSE |
| 3 | GTEx | Esophagus Mucosa | BRWD1-IT2 | 0.08 | 0.06 | lasso | 5 | 0.06 | 3.9e-05 | -4.2 | -5.4 | 5.6e-08 | -0.88 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | BRWD1 | 0.09 | 0.05 | lasso | 8 | 0.04 | 4.9e-04 | -4.7 | 5.2 | 2.1e-07 | 0.58 | 0.07 | 0.82 | FALSE |
| 5 | GTEx | Vagina | PSMG1 | 0.40 | 0.16 | lasso | 8 | 0.20 | 2.1e-05 | 4.4 | 5.4 | 5.5e-08 | 0.74 | 0.13 | 0.73 | TRUE |
| 6 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSMG1 | 0.07 | 0.07 | blup | 61 | 0.04 | 6.3e-03 | -4.9 | 5.1 | 2.8e-07 | 0.76 | 0.01 | 0.85 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMG1 | 0.04 | 0.04 | blup | 61 | 0.04 | 2.1e-05 | 4.5 | 5.4 | 8.0e-08 | 0.82 | 0.03 | 0.95 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PSMG1 | 0.07 | 0.04 | blup | 61 | 0.06 | 1.7e-03 | -2.9 | 5.2 | 1.8e-07 | 0.71 | 0.02 | 0.84 | FALSE |