TWAS
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Models
Genes
Traits
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Traits
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Body mass index (BMI)
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chr21:45,583,922-47,343,320
Best TWAS P=1.85e-10 · Best GWAS P=9.77e-14 conditioned to 0.00439
45.6M
45.8M
46M
46.2M
46.4M
46.6M
46.8M
47M
47.2M
47.4M
0
5
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
C21orf122
0.05
0.04
lasso
3
0.04
6.5e-05
6.4
-6.4
1.9e-10
0.60
0.00
1.00
TRUE
1
CommonMind
Brain Pre-frontal Cortex
ADARB1
0.12
0.03
blup
656
0.03
3.6e-04
-3.9
-5.5
3.0e-08
0.51
0.30
0.66
TRUE
5
The Cancer Genome Atlas
Pancreatic Adenocarcinoma
C21orf122
0.20
0.04
lasso
6
0.08
2.6e-04
6.4
-6.2
4.8e-10
0.57
0.00
0.99
FALSE
3
The Cancer Genome Atlas
Cervical Squamous Cell Carcinoma
ADARB1
0.07
0.01
blup
139
0.04
4.5e-03
5.8
-6.1
9.4e-10
0.83
0.01
0.90
FALSE
2
GTEx
Muscle Skeletal
PTTG1IP
0.07
0.01
enet
6
0.00
9.7e-02
-6.9
6.1
9.8e-10
-0.71
0.01
0.89
FALSE