Hub : Genes

ADARB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1210 0.0360 8.1e-05 0.031 0.026 0.020 NA 0.016 1.0e-04 0.00036 1.7e-03 NA 3.7e-03
2 GTEx Cells Transformed fibroblasts 0.3840 0.0570 7.2e-11 0.255 NA 0.274 NA 0.267 3.6e-19 NA 1.0e-20 NA 4.1e-20
3 GTEx Skin Not Sun Exposed Suprapubic 0.2530 0.0870 8.5e-03 -0.005 NA -0.003 NA -0.004 7.8e-01 NA 5.2e-01 NA 6.7e-01
4 TCGA Cervical Squamous Cell Carcinoma 0.0710 0.0420 7.1e-03 0.008 0.040 0.007 NA 0.019 1.3e-01 0.00450 1.3e-01 NA 3.7e-02
5 TCGA Prostate Adenocarcinoma 0.0594 0.0265 2.5e-04 0.044 0.040 0.040 NA 0.044 1.9e-05 0.00005 4.3e-05 NA 1.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.6 0.9 2.1 1.3 -0.7 0.0 -0.7 -1.4
Bipolar Disorder or Schizophrenia 0.3 0.6 1.4 1.2 -1.2 0.0 -0.6 -0.1
Depressed Affect (Nagel 2018) 0.5 1.1 3.4 -0.6 -1.0 0.0 -1.0 -1.8
Depression (Nagel 2018) 0.2 0.3 0.5 -0.7 -0.5 0.0 -0.6 -0.5
Intelligence (Savage-Jansen 2018) 1.1 3.5 6.3 1.6 2.0 0.0 2.5 2.2
Neuroticism (Nagel 2018) 0.2 0.6 1.4 -0.4 -1.0 0.0 -0.6 -1.2
Schizophrenia (2018) 0.2 0.5 1.0 0.6 -0.9 0.0 -0.2 1.0
Schizophrenia vs Biploar Disorder 1.3 1.7 5.0 2.2 0.6 0.0 1.4 1.1
Worry (Nagel 2018) 0.1 0.2 0.6 -0.1 -0.0 0.0 0.6 -0.8
Alzheimer’s Disease (in mother) 0.1 0.2 0.8 -0.1 0.0 0.0 0.0 -0.9
Alzheimer’s Disease (in father) 2.2 2.4 5.9 2.1 -0.9 0.0 1.0 -2.4
Alzheimer’s Disease (including proxy) 0.9 1.4 4.2 0.8 -1.2 0.0 0.6 -2.1
Crohns Disease (2017) 0.2 0.5 1.9 1.4 -0.6 0.0 -0.7 -0.2
Irritable Bowel Disease (IBD) 0.9 2.2 4.1 1.9 -2.0 0.0 -1.6 -0.7
Ulcerative Colitis (UC) 1.2 2.2 5.0 2.1 -2.2 0.0 -1.1 -0.7
Major Depression (MDD) 2.4 2.9 7.3 -2.3 -0.2 0.0 -2.7 -1.4
Reaction Time 0.3 0.5 1.0 -0.8 -0.6 0.0 -0.7 -1.0
Verbal and Numeric Reasoning (VNR) 0.8 2.0 3.8 1.9 0.8 0.0 1.6 1.8
Breast Cancer 0.6 1.5 3.4 -1.3 -1.1 0.0 -1.2 1.9
Ovarian Cancer 0.8 1.0 3.7 0.5 0.8 0.0 1.9 -0.7
Prostate Cancer 0.4 0.5 1.8 0.3 1.3 0.0 0.9 -0.1
Age at First Birth 1.5 2.2 5.8 2.4 0.7 0.0 1.7 1.3
Bipolar Disorder (2011) 0.6 0.6 3.0 0.0 0.0 0.0 -1.7 -0.3
Body Mass Index (BMI) (2010) 1.3 1.8 3.6 -1.8 -0.3 0.0 -1.4 -1.9
Coronary Artery Disease (CAD) 0.9 1.1 4.2 -2.0 0.0 0.0 -1.0 -0.6
Crohns Disease (2012) 0.2 0.4 0.9 1.0 -0.8 0.0 -0.3 -0.3
Mean Putamen Volume 0.7 0.8 2.3 -0.3 1.2 0.0 -0.6 1.5
Fasting Glucose 0.3 0.4 1.0 0.5 -1.0 0.0 -0.7 -0.6
HbA1C 0.7 0.7 1.4 -1.1 0.9 0.0 -0.5 1.2
HDL Cholesterol 1.6 2.6 5.0 2.0 2.2 0.0 1.9 0.6
LDL Cholesterol 0.1 0.1 0.5 -0.7 0.3 0.0 0.1 -0.2
Lupus 0.5 0.7 1.4 0.1 1.1 0.0 1.0 1.2
Neuroticism (2016) 0.6 0.8 2.3 -1.3 1.5 0.0 0.1 0.3
Primary Biliary Cirrhosis 1.1 1.6 5.7 1.1 -2.4 0.0 -1.0 0.1
Rheumatoid Arthritis 0.2 0.3 0.9 -0.1 -0.9 0.0 -0.2 0.9
Schizophrenia (2014) 0.6 1.4 5.6 2.4 -0.7 0.0 0.2 0.9
Triglycerides 1.2 1.9 5.6 -1.4 -0.4 0.0 -2.4 -1.3
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.4 0.3 0.3 0.0 -0.7 -1.2
Ulcerative Colitis 1.2 1.8 4.3 2.1 -1.8 0.0 -0.6 -1.1
Blood Eosinophil Count 0.4 3.1 6.3 -2.3 -2.0 0.0 -2.5 -0.3
Blood Platelet Count 0.3 3.0 6.1 1.9 -2.2 0.0 -2.5 0.9
Blood Red Count 0.0 0.4 1.4 -0.2 -1.2 0.0 -0.5 0.4
Blood White Count 1.0 7.2 19.8 -4.5 0.2 0.0 -4.0 0.6
Heel T-Score 0.4 2.9 7.0 -2.6 -0.3 0.0 -1.6 2.2
BMI 4.1 23.8 56.6 -7.0 -3.4 0.0 -7.5 -1.5
Height 0.1 1.1 3.8 0.6 -1.3 0.0 1.9 0.0
Waist Hip Ratio (WHR) 0.7 3.2 10.1 -0.2 1.9 0.0 1.4 -3.2
Systolic Blood Pressure 0.2 1.0 2.5 -1.6 1.5 0.0 0.6 -0.1
Smoking Status 1.3 3.2 11.5 -1.1 -1.7 0.0 -3.4 -0.5
Allergy or Eczema 0.5 1.2 4.0 -1.3 0.5 0.0 -0.5 2.0
Cardiovascular Disease 0.3 0.9 2.7 -0.7 -1.0 0.0 -1.6 -0.1
Hypothyroidism (self reported) 0.2 0.5 2.1 0.0 -1.5 0.0 -0.4 0.6
Respiratory disease 0.5 1.1 3.3 -1.3 -1.8 0.0 -0.9 0.0
Type 2 Diabetes (T2D) (2018) 1.5 2.8 7.1 -0.6 -2.4 0.0 -2.7 -1.0
Lung FEV1/FVC ratio 0.3 1.3 3.6 -1.9 1.2 0.0 0.1 1.1
Lung FVC 0.2 0.9 1.9 -0.9 -1.4 0.0 -0.6 -1.3
Neuroticism 0.5 1.3 6.5 0.0 -0.2 0.0 0.0 -2.6
Chronotype (morning person) 1.0 2.3 5.8 1.6 -0.2 0.0 1.8 2.4
Hair Pigment 0.1 3.2 7.4 -2.7 -1.1 0.0 -2.2 1.6
Tanning 0.1 1.4 4.5 0.3 2.1 0.0 1.2 -1.0
Hand grip strength (left) 2.6 6.9 22.6 -1.7 -2.9 0.0 -4.8 -0.8
Number of treatments/medications taken 0.7 1.2 2.6 -0.9 -1.6 0.0 -1.4 -0.8
Average weekly spirits intake 1.1 1.4 4.3 0.5 -2.1 0.0 -1.5 0.4
Sensitivity / hurt feelings 1.0 1.7 3.9 1.2 1.3 0.0 2.0 -1.1
Frequency of depressed mood in last 2 weeks 0.7 1.0 3.7 -0.0 -1.0 0.0 0.4 -1.9
Hearing difficulty/problems: Yes 1.6 2.5 6.3 2.5 0.7 0.0 2.4 -0.2
Relative age of first facial hair 0.4 0.7 2.6 1.0 0.3 0.0 1.6 -0.3
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 2.0 -1.1 1.4 0.0 1.3 -0.1
Ever used hormone-replacement therapy (HRT) 1.5 1.9 5.5 -1.6 1.1 0.0 -2.4 -0.1
Ever had hysterectomy (womb removed) 1.6 1.8 5.9 -1.6 0.3 0.0 -2.4 0.6
Systolic blood pressure, automated reading 1.4 4.1 8.0 -2.5 2.8 0.0 -1.6 2.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.2 0.4 -0.6 0.1 0.0 -0.5 0.3
Angina 1.8 2.4 4.7 -0.6 -2.2 0.0 -1.8 -1.9
Medication for hormone replacement therapy 0.1 0.1 0.2 0.0 -0.3 0.0 0.5 0.5
Vitamin and mineral supplements 0.1 0.2 0.3 0.4 0.3 0.0 -0.5 -0.5
Supplements: Zinc 0.6 0.7 2.3 0.1 0.7 0.0 0.7 1.5
Medication: Co-codamol 0.9 1.0 3.4 -0.5 -1.1 0.0 -0.5 -1.8
Medication: Metformin 0.7 1.0 2.5 -1.1 -0.9 0.0 -0.6 -1.6
Diabetes (father) 1.0 1.2 2.4 -0.7 -1.3 0.0 -1.2 -1.6
Diabetes (mother) 1.1 1.4 6.6 -0.0 0.1 0.0 0.7 -2.6
Severe depression (siblings) 0.4 0.4 1.1 -0.8 0.5 0.0 0.0 -1.1
Pack years adult smoking proportion 3.5 5.4 18.2 -2.5 -1.3 0.0 -4.3 -0.7
Impedance of leg (right) 1.6 7.8 17.4 2.7 3.8 0.0 4.2 -0.3
Leg fat-free mass (left) 1.9 10.0 20.0 -3.4 -4.3 0.0 -4.5 -0.5
Trunk fat percentage 2.7 11.0 27.8 -5.3 -1.2 0.0 -5.0 -0.8
Hand grip strength (right) 3.4 9.2 26.6 -2.9 -3.2 0.0 -5.2 0.8
Townsend deprivation index at recruitment 1.6 2.2 6.2 -2.5 -0.4 0.0 -2.1 -0.4
Current tobacco smoking 1.0 1.7 7.4 -0.6 -0.8 0.0 -2.7 -0.2
Average weekly fortified wine intake 0.7 0.9 1.8 1.2 1.0 0.0 1.4 -0.0
Maternal smoking around birth 0.3 0.5 1.7 -1.3 0.2 0.0 -0.1 0.9
Fed-up feelings 1.2 2.1 7.7 -0.2 -1.7 0.0 -0.3 -2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.2 -0.6 -0.8 0.0 -0.9 -1.5
Relative age voice broke 1.8 2.7 6.2 1.2 -0.7 0.0 2.5 -2.3
Taking other prescription medications 0.4 0.6 2.4 -1.6 -0.1 0.0 -0.8 0.1
Age when periods started (menarche) 1.7 4.1 9.7 1.0 -3.1 0.0 -2.9 -1.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 2.4 -0.2 -0.3 0.0 -1.5 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 6.5 -1.8 0.3 0.0 -1.3 2.5
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.5 -1.2 -1.0 0.0 0.1 0.0
Qualifications: CSEs or equivalent 0.5 0.6 1.1 -0.9 -1.0 0.0 0.2 1.1
Serious illness, injury or assault to yourself 1.4 1.7 6.2 -2.5 -0.9 0.0 -1.2 -0.5
High blood pressure 0.3 0.8 1.9 -1.1 0.2 0.0 -1.4 1.0
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.2 -1.3 -0.2 0.0 -0.1 1.5
Multivitamins +/- minerals 0.2 0.2 0.6 0.6 -0.8 0.0 0.2 0.1
Stomach or abdominal pain in last month 1.3 1.6 4.8 2.2 0.2 0.0 0.6 -1.6
Supplements: Glucosamine 0.6 0.8 1.9 1.4 -0.3 0.0 1.2 -0.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.7 -0.5 0.8 0.0 -0.2 0.1
Medication: Atenolol 0.7 0.9 2.0 0.9 -1.1 0.0 1.4 -0.6
Medication: Levothyroxine sodium 0.1 0.1 0.3 -0.3 -0.5 0.0 -0.0 -0.2
Sitting height 0.8 5.8 19.8 -0.7 -4.4 0.0 -2.9 0.2
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 -0.2 0.6 0.0 0.4 -0.4
High blood pressure (mother) 1.1 1.6 4.9 0.9 1.0 0.0 2.2 -1.0
Body mass index (BMI) 3.5 15.0 37.4 -5.5 -2.4 0.0 -6.1 -1.1
Impedance of leg (left) 1.3 6.2 11.8 2.6 3.4 0.0 3.4 -0.7
Leg predicted mass (left) 1.8 9.8 19.8 -3.4 -4.2 0.0 -4.4 -0.4
Trunk fat mass 2.9 12.7 29.4 -5.4 -2.0 0.0 -5.4 -0.9
Waist circumference 2.3 8.2 19.0 -4.4 -1.3 0.0 -4.4 -1.3
Number of incorrect matches in round 0.6 1.0 1.8 -1.4 -0.9 0.0 -1.2 0.8
Past tobacco smoking 1.2 2.2 6.4 1.7 0.8 0.0 2.5 -1.1
Alcohol usually taken with meals 1.5 2.4 5.0 1.8 1.8 0.0 2.2 0.7
Nervous feelings 0.3 0.5 1.7 0.8 -0.0 0.0 1.3 -0.4
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 5.2 0.4 -1.4 0.0 -0.9 -2.3
Hearing difficulty/problems with background noise 1.7 2.8 9.8 3.1 -0.4 0.0 1.6 -1.2
Hair/balding pattern: Pattern 2 0.5 0.6 1.5 1.0 -0.8 0.0 -0.1 -1.2
Had menopause 0.5 0.7 1.5 1.2 1.2 0.0 0.3 -0.5
Had other major operations 1.4 1.7 3.7 -1.6 -0.0 0.0 -1.9 1.5
Forced vital capacity (FVC) 0.3 1.3 4.1 -0.7 -2.0 0.0 -0.0 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 3.3 -0.9 -0.4 0.0 -0.8 1.8
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.1 -1.0 0.0 0.0 -1.0 -0.0
Qualifications: None of the above 0.5 1.0 2.3 -1.5 1.2 0.0 -1.1 0.1
Financial difficulties in last 2 years 1.5 2.1 4.2 -1.8 -0.9 0.0 -1.4 -2.1
Mouth/teeth dental problems 1.1 1.6 3.4 1.4 -1.8 0.0 -1.4 -0.8
Heart attack 1.7 2.2 10.2 -0.5 -3.2 0.0 -0.6 -0.6
Allergy 0.3 0.8 2.2 1.5 0.4 0.0 -0.3 -1.2
Pain all over the body in last month 0.1 0.1 0.4 -0.6 0.1 0.0 0.0 -0.6
Diabetes (self-reported) 1.7 2.7 7.4 0.3 -2.4 0.0 -2.7 -0.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.2 0.2 0.1 0.0 1.5 0.5
Medication: Ramipril 1.4 1.8 4.5 -0.4 -2.1 0.0 -0.2 -2.1
Medication: Simvastatin 1.1 1.6 4.8 -1.0 -2.2 0.0 -1.5 0.2
Fluid intelligence score 0.9 1.9 5.8 2.4 -0.1 0.0 1.4 1.3
Illnesses of siblings 0.6 0.8 1.4 1.0 -1.2 0.0 1.0 0.9
Neuroticism score 0.7 1.4 4.6 0.0 0.3 0.0 1.5 -2.1
Weight 2.5 12.4 28.7 -4.7 -3.1 0.0 -5.4 -1.4
Impedance of arm (right) 1.1 5.0 16.1 1.7 2.4 0.0 4.0 -0.4
Arm fat percentage (right) 3.3 13.0 35.7 -6.0 -1.4 0.0 -5.0 -1.5
Trunk fat-free mass 1.1 6.1 17.5 -1.5 -4.2 0.0 -3.1 -0.8
Hip circumference 2.0 8.7 22.1 -3.9 -2.5 0.0 -4.7 -0.6
Time employed in main current job 0.4 0.5 2.2 -0.4 1.5 0.0 0.1 -0.1
Alcohol intake versus 10 years previously 1.3 1.9 5.1 -1.7 -0.9 0.0 -0.8 -2.3
Father’s age at death 0.6 0.8 2.4 0.9 0.3 0.0 0.9 -1.6
Worrier / anxious feelings 2.2 4.2 7.6 2.8 0.2 0.0 2.6 -2.5
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.5 8.1 -1.7 -0.1 0.0 -1.3 -2.9
Falls in the last year 0.5 0.7 2.0 1.4 0.2 0.0 1.0 -0.6
Hair/balding pattern: Pattern 3 0.4 0.6 1.5 0.8 -0.7 0.0 0.4 1.2
Number of live births 0.4 0.6 2.3 -0.2 -0.4 0.0 -1.5 -0.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 3.1 -1.5 -1.8 0.0 -0.3 -1.2
Pulse rate 1.6 2.6 5.9 -2.1 2.4 0.0 -0.2 1.7
Happiness 0.5 0.6 1.4 -1.2 0.6 0.0 1.0 -0.4
Noisy workplace 1.1 1.3 3.0 -1.7 -0.3 0.0 -1.4 1.2
Qualifications: A levels/AS levels or equivalent 1.4 3.0 9.3 3.1 -1.1 0.0 2.0 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.0 0.1 1.4 0.0 1.0 -0.7
Mouth/teeth dental problems: Dentures 1.0 1.7 3.6 -1.9 1.2 0.0 -0.4 1.8
Asthma 1.0 2.0 3.2 -1.6 -1.8 0.0 -1.6 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.7 1.3 0.5 0.0 1.0 -1.3
Medication: Cholesterol lowering 1.1 1.7 5.4 -0.3 -2.3 0.0 -0.8 -1.5
Depression (self-reported) 1.6 1.9 6.7 -1.2 -0.8 0.0 -2.6 -1.0
Medication: Lansoprazole 0.5 0.5 2.6 -0.1 -0.1 0.0 -1.6 0.0
Prospective memory result 1.0 1.2 2.0 -1.4 1.3 0.0 0.9 1.2
Lung cancer (father) 0.8 0.9 2.2 1.1 -1.5 0.0 0.5 1.0
Illnesses of mother 0.8 0.9 2.4 1.3 -1.6 0.0 0.2 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 4.7 -1.2 -2.2 0.0 -0.1 -1.0
Pulse wave Arterial Stiffness index 2.0 2.3 9.3 -0.8 0.9 0.0 -0.9 3.0
Impedance of arm (left) 1.0 4.7 12.6 1.4 3.0 0.0 3.6 0.2
Arm fat mass (right) 3.1 12.7 29.2 -5.2 -2.2 0.0 -5.4 -1.4
Trunk predicted mass 1.0 5.7 16.1 -1.6 -4.0 0.0 -3.1 -0.8
Standing height 0.2 1.6 4.6 1.3 -2.2 0.0 0.7 -1.1
Length of working week for main job 0.4 0.5 1.4 -0.8 0.5 0.0 0.2 -1.2
Exposure to tobacco smoke at home 0.5 0.5 1.1 -0.6 -1.0 0.0 -1.0 -0.5
Breastfed as a baby 0.6 0.7 2.2 -1.5 -0.1 0.0 -1.0 0.6
Tense / ‘highly strung’ 0.2 0.4 1.2 -1.1 -0.1 0.0 -0.8 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.6 4.0 11.9 -2.3 -1.5 0.0 -3.5 -0.4
Hair/balding pattern: Pattern 4 0.5 1.3 3.8 -0.9 -1.1 0.0 -1.9 0.9
Birth weight of first child 2.1 3.8 10.8 -1.6 -2.0 0.0 -3.3 1.2
Peak expiratory flow (PEF) 0.4 1.0 1.8 -1.4 -1.0 0.0 0.7 -1.3
Pulse wave reflection index 0.9 1.1 3.4 0.3 -0.8 0.0 -1.2 1.9
Ever highly irritable/argumentative for 2 days 2.1 2.5 7.7 -2.1 -0.3 0.0 -2.8 -0.5
Loud music exposure frequency 1.2 1.3 2.5 -0.9 -1.6 0.0 -1.0 -1.4
Qualifications: O levels/GCSEs or equivalent 1.7 2.7 7.9 2.2 0.0 0.0 2.8 -1.0
Mouth/teeth dental problems: Bleeding gums 1.9 2.4 5.2 -1.8 2.3 0.0 1.8 0.8
Blood clot in the leg (DVT) 1.2 1.6 3.8 0.8 1.8 0.0 1.9 0.2
Medication: Paracetamol 0.1 0.2 0.8 -0.2 0.1 0.0 0.0 -0.9
Headache pain in last month 0.6 1.1 4.1 1.0 0.1 0.0 0.5 -2.0
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 6.5 -0.9 2.5 0.0 0.1 2.5
Glaucoma (self-reported) 0.3 0.4 1.0 -0.1 -1.0 0.0 0.4 0.8
Gout (self-reported) 0.4 0.6 1.8 0.3 -0.3 0.0 -1.0 -1.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.0 -0.4 -1.0 0.0 0.1 0.6
Medication: Amlodipine 0.2 0.3 1.3 -1.1 0.1 0.0 0.3 -0.4
Medication: Ventolin 100micrograms inhaler 2.7 3.5 12.1 0.5 -3.5 0.0 -1.9 -1.3
Birth weight 0.3 0.6 1.5 1.2 -0.2 0.0 -1.2 0.5
Chronic bronchitis/emphysema (mother) 1.6 1.8 4.6 -0.9 -1.9 0.0 -2.2 0.0
High blood pressure (siblings) 0.8 1.2 3.9 -1.4 0.3 0.0 -2.0 0.1
Forced vital capacity (FVC), Best measure 0.4 1.3 4.9 -0.6 -2.2 0.0 0.1 -1.2
Body fat percentage 3.1 12.2 32.7 -5.7 -0.8 0.0 -5.2 -0.8
Leg fat percentage (right) 2.8 10.2 29.7 -5.5 -0.2 0.0 -4.6 -0.8
Arm fat-free mass (right) 1.5 7.9 20.0 -2.6 -3.6 0.0 -4.5 -0.2
Exposure to tobacco smoke outside home 1.1 1.4 3.5 -1.3 -1.3 0.0 -1.9 0.1
Comparative body size at age 10 0.3 0.8 2.8 -0.9 0.5 0.0 0.1 -1.7
Number of full brothers 1.5 1.9 5.6 -2.4 -0.7 0.0 -0.7 -1.7
Worry too long after embarrassment 0.4 0.7 1.5 1.2 -1.0 0.0 0.9 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.5 3.3 10.0 -2.0 -1.5 0.0 -3.2 -0.2
Wheeze or whistling in the chest in last year 1.6 2.8 7.7 -1.6 -1.9 0.0 -2.8 -0.5
Number of children fathered 1.1 1.2 3.3 1.2 -1.8 0.0 -1.0 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.1 1.3 0.4 0.0 -1.3 1.4
Age at first live birth 1.7 3.0 7.2 2.3 0.5 0.0 2.7 1.6
Pulse wave peak to peak time 2.1 2.5 10.1 0.8 -1.0 0.0 0.8 -3.2
Health satisfaction 0.6 0.8 2.4 -1.6 0.2 0.0 -1.1 -0.7
Shortness of breath walking on level ground 0.3 0.4 0.8 -0.6 0.9 0.0 -0.4 0.7
Qualifications: College or University degree 1.0 3.3 10.4 3.2 0.3 0.0 2.2 -1.0
Eye problems/disorders: None of the above 0.7 0.8 1.4 1.0 0.7 0.0 1.2 -1.0
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.5 -1.5 0.1 0.0 -1.9 -0.6
Emphysema/chronic bronchitis 1.4 1.5 3.1 0.0 -1.7 0.0 -1.2 -1.8
Medication for pain relief, constipation, heartburn 0.3 0.5 1.4 0.2 0.7 0.0 1.2 0.8
Neck or shoulder pain in last month 0.5 0.7 1.7 -0.6 0.9 0.0 0.8 -1.3
Medication: Blood pressure 1.4 2.5 6.4 1.1 -2.2 0.0 0.4 -2.5
Angina (self-reported) 1.7 2.3 4.7 -0.5 -2.2 0.0 -1.8 -1.7
Migraine (self-reported) 0.3 0.3 0.9 -0.8 0.1 0.0 0.3 0.9
Medication: Ibuprofen 1.1 1.3 4.9 0.7 0.6 0.0 0.9 -2.2
Medication: Allopurinol 0.7 0.9 3.3 -0.4 -0.7 0.0 -1.8 -0.9
Medication: Omeprazole 1.4 1.7 4.9 -0.7 -1.8 0.0 -2.2 0.0
Medication: Seretide 50 evohaler 1.3 1.5 4.7 0.3 -2.2 0.0 -1.2 1.0
Mean time to correctly identify matches 0.2 0.3 0.8 -0.7 -0.3 0.0 -0.9 -0.4
Heart disease (mother) 1.2 1.4 5.6 -1.2 -0.3 0.0 -2.4 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.8 1.7 1.0 1.3 0.0 0.1 1.0
Whole body fat mass 3.0 12.3 28.9 -5.3 -1.8 0.0 -5.4 -1.1
Leg fat mass (right) 3.3 12.9 30.4 -5.5 -1.8 0.0 -5.5 -1.0
Arm predicted mass (right) 1.7 8.7 22.3 -2.6 -3.8 0.0 -4.7 -0.3
Pulse rate, automated reading 1.1 3.5 8.0 -2.6 2.8 0.0 -0.2 1.7
Alcohol intake frequency. 0.8 1.9 8.2 -0.9 -0.6 0.0 -0.5 -2.9
Comparative height size at age 10 0.1 0.6 1.5 -0.4 0.2 0.0 1.2 -1.0
Number of full sisters 1.0 1.2 2.8 -1.4 -0.8 0.0 -1.7 -0.7
Suffer from ‘nerves’ 0.3 0.5 1.5 -0.8 -0.2 0.0 0.7 -1.2
Overall health rating 0.8 1.8 6.1 -2.5 -0.6 0.0 -1.5 -0.3
Chest pain or discomfort 1.2 1.7 3.8 -1.3 -0.3 0.0 -1.8 -1.9
Had major operations 0.8 1.0 2.9 -0.9 -1.0 0.0 -1.7 -0.4
Age at last live birth 1.7 2.4 7.9 1.1 -0.2 0.0 1.7 2.8
Family relationship satisfaction 0.2 0.2 0.3 0.5 -0.2 0.0 0.6 0.6
Leg pain on walking 1.4 1.8 5.8 -0.6 -0.7 0.0 -2.4 -1.6
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 5.2 -0.2 -2.3 0.0 -1.1 0.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.9 -0.9 0.1 0.0 -1.7 0.4
Illness, injury, bereavement, stress in last 2 years 2.5 3.0 9.5 3.1 -0.7 0.0 0.5 2.2
Medication: Aspirin 0.6 0.7 1.1 -0.8 -0.9 0.0 -1.1 -1.0
Supplements: Vitamin C 0.4 0.5 1.1 0.2 0.6 0.0 0.9 -1.0
Knee pain experienced in last month 1.0 1.6 3.8 -0.0 -1.2 0.0 -1.7 -1.9
Hypertension (Self-reported) 0.4 1.1 2.4 -1.6 0.1 0.0 -1.5 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.6 -0.2 -0.5 0.0 -1.3 0.0
Illnesses of father: Heart disease 0.9 1.3 3.7 -1.9 -0.4 0.0 -1.3 -0.8
Illnesses of siblings: Diabetes 0.6 0.7 2.1 0.3 -0.4 0.0 -1.2 -1.5
Smoking status: Previous 0.8 1.1 2.1 -1.5 -0.7 0.0 -1.4 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 3.5 -0.8 -1.9 0.0 -0.9 0.7
Whole body fat-free mass 1.4 8.3 19.8 -2.4 -4.5 0.0 -3.9 -0.7
Leg fat-free mass (right) 1.9 10.3 21.7 -3.1 -4.5 0.0 -4.7 -0.6
Arm fat percentage (left) 3.3 13.4 37.5 -6.1 -1.1 0.0 -5.2 -1.2
Average weekly red wine intake 0.8 1.2 3.3 0.7 1.1 0.0 1.8 0.9
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.3 0.5 -0.8 0.0 -1.5 1.1
Mood swings 0.4 0.8 2.0 -0.8 -1.4 0.0 -1.0 -0.6
Loneliness, isolation 0.2 0.3 1.5 0.1 -1.2 0.0 -0.3 0.1
Long-standing illness, disability or infirmity 1.3 2.0 3.1 -1.4 -1.4 0.0 -1.7 -1.8
Ever had bowel cancer screening 0.0 0.0 0.1 0.2 0.2 0.0 0.2 -0.2
Diabetes diagnosed by doctor 1.5 2.5 7.4 0.0 -2.2 0.0 -2.7 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.2 4.7 -1.3 -0.9 0.0 -1.9 2.2
Friendships satisfaction 0.7 0.8 1.8 1.0 0.3 0.0 1.4 -1.1
Qualifications: nursing, teaching 0.5 0.7 1.8 1.2 -1.3 0.0 0.4 -0.1
Commuting to job workplace: Walk 1.3 1.4 3.1 1.5 1.2 0.0 1.8 -0.4
Eye problems/disorders: Cataract 0.9 1.0 2.7 -0.7 -0.9 0.0 -1.6 1.1
Mouth/teeth dental problems: Mouth ulcers 1.9 3.0 8.9 2.2 0.2 0.0 3.0 -1.1
Medication for cholesterol 1.3 2.0 7.6 2.7 -0.4 0.0 1.3 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.7 5.5 -0.4 -1.5 0.0 -2.3 -0.8
Back pain experienced in last month 1.1 1.7 3.4 -0.7 -1.5 0.0 -1.9 -1.4
Mineral and other dietary supplements 0.6 0.8 1.8 -1.0 0.1 0.0 -1.0 -1.3
Breast cancer (self-reported) 1.4 1.7 6.0 0.4 1.3 0.0 2.5 0.6
Asthma (self-reported) 1.1 2.2 4.1 -1.7 -2.0 0.0 -1.8 1.0
Osteoporosis (self-reported) 0.8 0.9 2.1 1.0 1.5 0.0 0.9 0.8
Osteoarthritis (self-reported) 0.7 0.9 1.9 -1.4 1.1 0.0 -0.9 -0.7
Medication: Aspirin 1.1 1.4 2.2 -0.7 -1.4 0.0 -1.5 -1.5
Medication: Gliclazide 0.1 0.1 0.2 -0.1 0.4 0.0 -0.5 -0.3
Illnesses of father: None of the above (group 1) 0.6 0.7 3.1 0.2 0.3 0.0 -0.5 1.8
Smoking status: Current 1.0 1.6 7.2 -0.4 -0.9 0.0 -2.7 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 9.1 -3.0 -0.6 0.0 0.1 0.4
Whole body water mass 1.4 8.1 19.3 -2.3 -4.4 0.0 -4.0 -0.7
Leg predicted mass (right) 2.0 10.7 23.0 -3.1 -4.5 0.0 -4.8 -0.4
Arm fat mass (left) 3.2 13.0 30.2 -5.4 -1.9 0.0 -5.5 -1.3
Number of self-reported non-cancer illnesses 0.4 0.7 1.5 -1.0 -1.0 0.0 -1.2 -0.4
Average weekly champagne plus white wine intake 1.9 2.6 4.4 2.0 2.1 0.0 2.1 0.4
Miserableness 0.5 0.8 2.8 -0.3 -0.8 0.0 -0.7 -1.7
Guilty feelings 0.4 0.5 2.6 0.3 0.1 0.0 -0.1 -1.6
Wears glasses or contact lenses 0.1 0.1 0.3 -0.1 0.5 0.0 0.1 0.3
Ever taken oral contraceptive pill 1.4 1.6 5.9 -0.4 -1.0 0.0 -2.4 -0.9
Hearing aid user 1.1 1.2 3.2 1.8 -0.2 0.0 1.6 0.2
Mother’s age at death 0.0 0.1 0.1 0.2 0.3 0.0 0.3 0.3
Financial situation satisfaction 1.0 1.2 2.7 -1.1 -0.4 0.0 -1.4 -1.6
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.1 -0.9 -0.9 0.0 -0.7 -1.0
Commuting to job workplace: Public transport 0.7 0.8 2.0 1.4 0.6 0.0 1.1 -0.7
Eye problems/disorders: Glaucoma 0.4 0.4 1.7 0.1 -0.7 0.0 -0.2 1.3
Medication: Blood pressure 0.7 1.4 3.5 -1.9 1.7 0.0 0.1 -0.6
Pain type(s) experienced in last month: Hip pain 1.9 2.4 10.3 -1.0 -0.4 0.0 -0.8 -3.2
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.0 1.0 -0.7 0.0 0.2 0.7
High cholesterol (Self-reported) 0.3 0.6 1.5 -1.1 -0.5 0.0 -1.2 0.1
Medication: Bendroflumethiazide 0.1 0.2 0.5 0.7 0.2 0.0 0.1 0.5
Medication: Paracetamol 0.2 0.3 0.8 -0.7 0.3 0.0 -0.6 -0.9
Medication: Lisinopril 0.5 0.7 1.4 1.0 -0.7 0.0 0.6 -1.2
Medication: Atorvastatin 0.3 0.4 0.9 -0.9 -0.6 0.0 -0.0 -0.8
Illnesses of father: High blood pressure 1.0 1.3 3.2 0.8 0.8 0.0 1.3 -1.8
Alcohol drinker status: Never 1.8 2.2 8.8 0.5 3.0 0.0 1.3 0.2
Ever smoked 0.5 0.9 3.2 -1.1 0.0 0.0 -1.8 0.3
Basal metabolic rate 1.7 9.5 19.8 -3.0 -4.2 0.0 -4.5 -0.8
Leg fat percentage (left) 3.2 11.6 30.2 -5.5 -0.5 0.0 -5.1 -1.1
Arm fat-free mass (left) 1.5 7.7 18.0 -2.5 -3.7 0.0 -4.2 -0.8
Number of operations (self-reported) 2.1 3.1 11.2 -0.8 -1.9 0.0 -3.4 0.3
Average weekly beer plus cider intake 3.8 5.5 13.3 -3.6 -1.1 0.0 -3.6 -0.3
Irritability 0.9 1.5 5.0 -0.8 -1.3 0.0 0.0 -2.2
Risk taking 1.2 1.8 6.6 -0.2 -1.5 0.0 -2.6 -0.3
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.6 1.6 0.9 0.0 1.2 -0.8
Fractured/broken bones in last 5 years 0.3 0.3 1.2 -1.1 0.5 0.0 -0.3 -0.3
Age started oral contraceptive pill 1.3 1.6 3.9 1.4 2.0 0.0 0.8 1.2
Diastolic blood pressure, automated reading 1.4 4.3 9.9 -3.0 -0.0 0.0 -3.1 1.6
Ever depressed for a whole week 1.2 1.5 3.2 -0.6 -1.5 0.0 -1.8 -1.4
Unable to work because of sickness or disability 1.7 2.2 4.5 -1.9 -0.3 0.0 -1.7 -2.1
Commuting to job workplace: Cycle 0.5 0.6 1.2 0.3 1.1 0.0 1.0 -1.0
Myopia 0.8 1.1 2.8 1.7 0.4 0.0 1.3 -1.0
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.9 0.9 0.2 0.0 0.9 -0.7
Cholesterol lowering medication 2.2 3.2 9.0 -2.2 -1.4 0.0 -3.0 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.9 -0.4 -1.2 0.0 -1.4 0.1
Pain experienced in last month 0.1 0.1 0.3 0.2 0.3 0.0 0.5 0.4
Supplements: Calcium 2.2 2.4 6.3 -2.0 1.3 0.0 -0.4 2.5
Basal cell carcinoma (self-reported) 0.4 0.5 1.1 -0.4 -0.8 0.0 -1.1 0.6
Heart attack/myocardial infarction (self-reported) 1.7 2.1 9.7 -0.6 -3.1 0.0 -0.6 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.0 1.0 1.0 0.0 1.4 0.2
Heart disease (siblings) 0.6 0.8 3.0 -1.7 0.7 0.0 -0.1 -0.5
Alcohol drinker status: Previous 1.3 1.4 3.3 1.0 -1.0 0.0 -1.4 -1.8
Pack years of smoking 3.3 4.8 16.7 -2.5 -1.1 0.0 -4.1 -0.1
Impedance of whole body 1.3 6.8 16.5 2.1 3.6 0.0 4.1 -0.4
Leg fat mass (left) 3.6 13.9 33.9 -5.5 -2.0 0.0 -5.8 -1.2
Arm predicted mass (left) 1.6 8.2 17.5 -2.7 -4.0 0.0 -4.2 -0.7