TWAS hub - ADARB1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1210	0.0360	8.1e-05	0.031	0.026	0.020	NA	0.016	1.0e-04	0.00036	1.7e-03	NA	3.7e-03
2	GTEx	Cells Transformed fibroblasts	0.3840	0.0570	7.2e-11	0.255	NA	0.274	NA	0.267	3.6e-19	NA	1.0e-20	NA	4.1e-20
3	GTEx	Skin Not Sun Exposed Suprapubic	0.2530	0.0870	8.5e-03	-0.005	NA	-0.003	NA	-0.004	7.8e-01	NA	5.2e-01	NA	6.7e-01
4	TCGA	Cervical Squamous Cell Carcinoma	0.0710	0.0420	7.1e-03	0.008	0.040	0.007	NA	0.019	1.3e-01	0.00450	1.3e-01	NA	3.7e-02
5	TCGA	Prostate Adenocarcinoma	0.0594	0.0265	2.5e-04	0.044	0.040	0.040	NA	0.044	1.9e-05	0.00005	4.3e-05	NA	1.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5
BMI	4.1	23.8	56.6	-7.0	-3.4	-7.5	-1.5
Average weekly beer plus cider intake	3.8	5.5	13.3	-3.6	-1.1	-3.6	-0.3
Leg fat mass (left)	3.6	13.9	33.9	-5.5	-2.0	-5.8	-1.2
Pack years adult smoking proportion	3.5	5.4	18.2	-2.5	-1.3	-4.3	-0.7
Body mass index (BMI)	3.5	15.0	37.4	-5.5	-2.4	-6.1	-1.1
Hand grip strength (right)	3.4	9.2	26.6	-2.9	-3.2	-5.2	0.8
Arm fat percentage (right)	3.3	13.0	35.7	-6.0	-1.4	-5.0	-1.5
Leg fat mass (right)	3.3	12.9	30.4	-5.5	-1.8	-5.5	-1.0
Arm fat percentage (left)	3.3	13.4	37.5	-6.1	-1.1	-5.2	-1.2
Pack years of smoking	3.3	4.8	16.7	-2.5	-1.1	-4.1	-0.1
Arm fat mass (left)	3.2	13.0	30.2	-5.4	-1.9	-5.5	-1.3
Leg fat percentage (left)	3.2	11.6	30.2	-5.5	-0.5	-5.1	-1.1
Arm fat mass (right)	3.1	12.7	29.2	-5.2	-2.2	-5.4	-1.4
Body fat percentage	3.1	12.2	32.7	-5.7	-0.8	-5.2	-0.8
Whole body fat mass	3.0	12.3	28.9	-5.3	-1.8	-5.4	-1.1
Trunk fat mass	2.9	12.7	29.4	-5.4	-2.0	-5.4	-0.9
Leg fat percentage (right)	2.8	10.2	29.7	-5.5	-0.2	-4.6	-0.8
Trunk fat percentage	2.7	11.0	27.8	-5.3	-1.2	-5.0	-0.8
Medication: Ventolin 100micrograms inhaler	2.7	3.5	12.1	0.5	-3.5	-1.9	-1.3
Hand grip strength (left)	2.6	6.9	22.6	-1.7	-2.9	-4.8	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.0	11.9	-2.3	-1.5	-3.5	-0.4
Weight	2.5	12.4	28.7	-4.7	-3.1	-5.4	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.3	10.0	-2.0	-1.5	-3.2	-0.2
Illness, injury, bereavement, stress in last 2 years	2.5	3.0	9.5	3.1	-0.7	0.5	2.2
Major Depression (MDD)	2.4	2.9	7.3	-2.3	-0.2	-2.7	-1.4
Waist circumference	2.3	8.2	19.0	-4.4	-1.3	-4.4	-1.3
Alzheimer’s Disease (in father)	2.2	2.4	5.9	2.1	-0.9	1.0	-2.4
Worrier / anxious feelings	2.2	4.2	7.6	2.8	0.2	2.6	-2.5
Cholesterol lowering medication	2.2	3.2	9.0	-2.2	-1.4	-3.0	-0.1
Supplements: Calcium	2.2	2.4	6.3	-2.0	1.3	-0.4	2.5
Birth weight of first child	2.1	3.8	10.8	-1.6	-2.0	-3.3	1.2
Ever highly irritable/argumentative for 2 days	2.1	2.5	7.7	-2.1	-0.3	-2.8	-0.5
Pulse wave peak to peak time	2.1	2.5	10.1	0.8	-1.0	0.8	-3.2
Number of operations (self-reported)	2.1	3.1	11.2	-0.8	-1.9	-3.4	0.3
Hip circumference	2.0	8.7	22.1	-3.9	-2.5	-4.7	-0.6
Pulse wave Arterial Stiffness index	2.0	2.3	9.3	-0.8	0.9	-0.9	3.0
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	4.7	-1.3	-0.9	-1.9	2.2
Leg predicted mass (right)	2.0	10.7	23.0	-3.1	-4.5	-4.8	-0.4
Leg fat-free mass (left)	1.9	10.0	20.0	-3.4	-4.3	-4.5	-0.5
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	5.2	-1.8	2.3	1.8	0.8
Leg fat-free mass (right)	1.9	10.3	21.7	-3.1	-4.5	-4.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	8.9	2.2	0.2	3.0	-1.1
Average weekly champagne plus white wine intake	1.9	2.6	4.4	2.0	2.1	2.1	0.4
Pain type(s) experienced in last month: Hip pain	1.9	2.4	10.3	-1.0	-0.4	-0.8	-3.2
Angina	1.8	2.4	4.7	-0.6	-2.2	-1.8	-1.9
Relative age voice broke	1.8	2.7	6.2	1.2	-0.7	2.5	-2.3
Leg predicted mass (left)	1.8	9.8	19.8	-3.4	-4.2	-4.4	-0.4
Alcohol drinker status: Never	1.8	2.2	8.8	0.5	3.0	1.3	0.2
Age when periods started (menarche)	1.7	4.1	9.7	1.0	-3.1	-2.9	-1.1
Hearing difficulty/problems with background noise	1.7	2.8	9.8	3.1	-0.4	1.6	-1.2
Heart attack	1.7	2.2	10.2	-0.5	-3.2	-0.6	-0.6
Diabetes (self-reported)	1.7	2.7	7.4	0.3	-2.4	-2.7	-0.0
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	7.9	2.2	0.0	2.8	-1.0
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	6.5	-0.9	2.5	0.1	2.5
Age at first live birth	1.7	3.0	7.2	2.3	0.5	2.7	1.6
Angina (self-reported)	1.7	2.3	4.7	-0.5	-2.2	-1.8	-1.7
Arm predicted mass (right)	1.7	8.7	22.3	-2.6	-3.8	-4.7	-0.3
Age at last live birth	1.7	2.4	7.9	1.1	-0.2	1.7	2.8
Basal metabolic rate	1.7	9.5	19.8	-3.0	-4.2	-4.5	-0.8
Unable to work because of sickness or disability	1.7	2.2	4.5	-1.9	-0.3	-1.7	-2.1
Heart attack/myocardial infarction (self-reported)	1.7	2.1	9.7	-0.6	-3.1	-0.6	-0.5
HDL Cholesterol	1.6	2.6	5.0	2.0	2.2	1.9	0.6
Hearing difficulty/problems: Yes	1.6	2.5	6.3	2.5	0.7	2.4	-0.2
Ever had hysterectomy (womb removed)	1.6	1.8	5.9	-1.6	0.3	-2.4	0.6
Impedance of leg (right)	1.6	7.8	17.4	2.7	3.8	4.2	-0.3
Townsend deprivation index at recruitment	1.6	2.2	6.2	-2.5	-0.4	-2.1	-0.4
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	8.1	-1.7	-0.1	-1.3	-2.9
Pulse rate	1.6	2.6	5.9	-2.1	2.4	-0.2	1.7
Depression (self-reported)	1.6	1.9	6.7	-1.2	-0.8	-2.6	-1.0
Chronic bronchitis/emphysema (mother)	1.6	1.8	4.6	-0.9	-1.9	-2.2	0.0
Wheeze or whistling in the chest in last year	1.6	2.8	7.7	-1.6	-1.9	-2.8	-0.5
Arm predicted mass (left)	1.6	8.2	17.5	-2.7	-4.0	-4.2	-0.7
Age at First Birth	1.5	2.2	5.8	2.4	0.7	1.7	1.3
Type 2 Diabetes (T2D) (2018)	1.5	2.8	7.1	-0.6	-2.4	-2.7	-1.0
Ever used hormone-replacement therapy (HRT)	1.5	1.9	5.5	-1.6	1.1	-2.4	-0.1
Alcohol usually taken with meals	1.5	2.4	5.0	1.8	1.8	2.2	0.7
Financial difficulties in last 2 years	1.5	2.1	4.2	-1.8	-0.9	-1.4	-2.1
Arm fat-free mass (right)	1.5	7.9	20.0	-2.6	-3.6	-4.5	-0.2
Number of full brothers	1.5	1.9	5.6	-2.4	-0.7	-0.7	-1.7
Diabetes diagnosed by doctor	1.5	2.5	7.4	0.0	-2.2	-2.7	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	5.5	-0.4	-1.5	-2.3	-0.8
Arm fat-free mass (left)	1.5	7.7	18.0	-2.5	-3.7	-4.2	-0.8
Systolic blood pressure, automated reading	1.4	4.1	8.0	-2.5	2.8	-1.6	2.0
Serious illness, injury or assault to yourself	1.4	1.7	6.2	-2.5	-0.9	-1.2	-0.5
Had other major operations	1.4	1.7	3.7	-1.6	-0.0	-1.9	1.5
Medication: Ramipril	1.4	1.8	4.5	-0.4	-2.1	-0.2	-2.1
Qualifications: A levels/AS levels or equivalent	1.4	3.0	9.3	3.1	-1.1	2.0	0.5
Emphysema/chronic bronchitis	1.4	1.5	3.1	0.0	-1.7	-1.2	-1.8
Medication: Blood pressure	1.4	2.5	6.4	1.1	-2.2	0.4	-2.5
Medication: Omeprazole	1.4	1.7	4.9	-0.7	-1.8	-2.2	0.0
Leg pain on walking	1.4	1.8	5.8	-0.6	-0.7	-2.4	-1.6
Whole body fat-free mass	1.4	8.3	19.8	-2.4	-4.5	-3.9	-0.7
Breast cancer (self-reported)	1.4	1.7	6.0	0.4	1.3	2.5	0.6
Whole body water mass	1.4	8.1	19.3	-2.3	-4.4	-4.0	-0.7
Ever taken oral contraceptive pill	1.4	1.6	5.9	-0.4	-1.0	-2.4	-0.9
Diastolic blood pressure, automated reading	1.4	4.3	9.9	-3.0	-0.0	-3.1	1.6
Schizophrenia vs Biploar Disorder	1.3	1.7	5.0	2.2	0.6	1.4	1.1
Body Mass Index (BMI) (2010)	1.3	1.8	3.6	-1.8	-0.3	-1.4	-1.9
Smoking Status	1.3	3.2	11.5	-1.1	-1.7	-3.4	-0.5
Stomach or abdominal pain in last month	1.3	1.6	4.8	2.2	0.2	0.6	-1.6
Impedance of leg (left)	1.3	6.2	11.8	2.6	3.4	3.4	-0.7
Alcohol intake versus 10 years previously	1.3	1.9	5.1	-1.7	-0.9	-0.8	-2.3
Medication: Seretide 50 evohaler	1.3	1.5	4.7	0.3	-2.2	-1.2	1.0
Long-standing illness, disability or infirmity	1.3	2.0	3.1	-1.4	-1.4	-1.7	-1.8
Commuting to job workplace: Walk	1.3	1.4	3.1	1.5	1.2	1.8	-0.4
Medication for cholesterol	1.3	2.0	7.6	2.7	-0.4	1.3	-0.7
Age started oral contraceptive pill	1.3	1.6	3.9	1.4	2.0	0.8	1.2
Alcohol drinker status: Previous	1.3	1.4	3.3	1.0	-1.0	-1.4	-1.8
Impedance of whole body	1.3	6.8	16.5	2.1	3.6	4.1	-0.4
Ulcerative Colitis (UC)	1.2	2.2	5.0	2.1	-2.2	-1.1	-0.7
Triglycerides	1.2	1.9	5.6	-1.4	-0.4	-2.4	-1.3
Ulcerative Colitis	1.2	1.8	4.3	2.1	-1.8	-0.6	-1.1
Fed-up feelings	1.2	2.1	7.7	-0.2	-1.7	-0.3	-2.8
Past tobacco smoking	1.2	2.2	6.4	1.7	0.8	2.5	-1.1
Loud music exposure frequency	1.2	1.3	2.5	-0.9	-1.6	-1.0	-1.4
Blood clot in the leg (DVT)	1.2	1.6	3.8	0.8	1.8	1.9	0.2
Heart disease (mother)	1.2	1.4	5.6	-1.2	-0.3	-2.4	0.2
Chest pain or discomfort	1.2	1.7	3.8	-1.3	-0.3	-1.8	-1.9
Risk taking	1.2	1.8	6.6	-0.2	-1.5	-2.6	-0.3
Ever depressed for a whole week	1.2	1.5	3.2	-0.6	-1.5	-1.8	-1.4
Intelligence (Savage-Jansen 2018)	1.1	3.5	6.3	1.6	2.0	2.5	2.2
Primary Biliary Cirrhosis	1.1	1.6	5.7	1.1	-2.4	-1.0	0.1
Average weekly spirits intake	1.1	1.4	4.3	0.5	-2.1	-1.5	0.4
Diabetes (mother)	1.1	1.4	6.6	-0.0	0.1	0.7	-2.6
High blood pressure (mother)	1.1	1.6	4.9	0.9	1.0	2.2	-1.0
Mouth/teeth dental problems	1.1	1.6	3.4	1.4	-1.8	-1.4	-0.8
Medication: Simvastatin	1.1	1.6	4.8	-1.0	-2.2	-1.5	0.2
Impedance of arm (right)	1.1	5.0	16.1	1.7	2.4	4.0	-0.4
Trunk fat-free mass	1.1	6.1	17.5	-1.5	-4.2	-3.1	-0.8
Noisy workplace	1.1	1.3	3.0	-1.7	-0.3	-1.4	1.2
Medication: Cholesterol lowering	1.1	1.7	5.4	-0.3	-2.3	-0.8	-1.5
Exposure to tobacco smoke outside home	1.1	1.4	3.5	-1.3	-1.3	-1.9	0.1
Number of children fathered	1.1	1.2	3.3	1.2	-1.8	-1.0	0.6
Medication: Ibuprofen	1.1	1.3	4.9	0.7	0.6	0.9	-2.2
Pulse rate, automated reading	1.1	3.5	8.0	-2.6	2.8	-0.2	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	5.2	-0.2	-2.3	-1.1	0.1
Back pain experienced in last month	1.1	1.7	3.4	-0.7	-1.5	-1.9	-1.4
Asthma (self-reported)	1.1	2.2	4.1	-1.7	-2.0	-1.8	1.0
Medication: Aspirin	1.1	1.4	2.2	-0.7	-1.4	-1.5	-1.5
Hearing aid user	1.1	1.2	3.2	1.8	-0.2	1.6	0.2
Blood White Count	1.0	7.2	19.8	-4.5	0.2	-4.0	0.6
Chronotype (morning person)	1.0	2.3	5.8	1.6	-0.2	1.8	2.4
Sensitivity / hurt feelings	1.0	1.7	3.9	1.2	1.3	2.0	-1.1
Diabetes (father)	1.0	1.2	2.4	-0.7	-1.3	-1.2	-1.6
Current tobacco smoking	1.0	1.7	7.4	-0.6	-0.8	-2.7	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	6.5	-1.8	0.3	-1.3	2.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	5.2	0.4	-1.4	-0.9	-2.3
Mouth/teeth dental problems: Dentures	1.0	1.7	3.6	-1.9	1.2	-0.4	1.8
Asthma	1.0	2.0	3.2	-1.6	-1.8	-1.6	1.2
Prospective memory result	1.0	1.2	2.0	-1.4	1.3	0.9	1.2
Impedance of arm (left)	1.0	4.7	12.6	1.4	3.0	3.6	0.2
Trunk predicted mass	1.0	5.7	16.1	-1.6	-4.0	-3.1	-0.8
Qualifications: College or University degree	1.0	3.3	10.4	3.2	0.3	2.2	-1.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.5	-1.5	0.1	-1.9	-0.6
Number of full sisters	1.0	1.2	2.8	-1.4	-0.8	-1.7	-0.7
Knee pain experienced in last month	1.0	1.6	3.8	-0.0	-1.2	-1.7	-1.9
Smoking status: Current	1.0	1.6	7.2	-0.4	-0.9	-2.7	-0.2
Financial situation satisfaction	1.0	1.2	2.7	-1.1	-0.4	-1.4	-1.6
Illnesses of father: High blood pressure	1.0	1.3	3.2	0.8	0.8	1.3	-1.8
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.6	1.6	0.9	1.2	-0.8
Alzheimer’s Disease (including proxy)	0.9	1.4	4.2	0.8	-1.2	0.6	-2.1
Irritable Bowel Disease (IBD)	0.9	2.2	4.1	1.9	-2.0	-1.6	-0.7
Coronary Artery Disease (CAD)	0.9	1.1	4.2	-2.0	0.0	-1.0	-0.6
Medication: Co-codamol	0.9	1.0	3.4	-0.5	-1.1	-0.5	-1.8
Fluid intelligence score	0.9	1.9	5.8	2.4	-0.1	1.4	1.3
Pulse wave reflection index	0.9	1.1	3.4	0.3	-0.8	-1.2	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.1	1.3	0.4	-1.3	1.4
Illnesses of father: Heart disease	0.9	1.3	3.7	-1.9	-0.4	-1.3	-0.8
Eye problems/disorders: Cataract	0.9	1.0	2.7	-0.7	-0.9	-1.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	9.1	-3.0	-0.6	0.1	0.4
Irritability	0.9	1.5	5.0	-0.8	-1.3	0.0	-2.2
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.8	1.9	0.8	1.6	1.8
Ovarian Cancer	0.8	1.0	3.7	0.5	0.8	1.9	-0.7
Sitting height	0.8	5.8	19.8	-0.7	-4.4	-2.9	0.2
Lung cancer (father)	0.8	0.9	2.2	1.1	-1.5	0.5	1.0
Illnesses of mother	0.8	0.9	2.4	1.3	-1.6	0.2	-0.8
High blood pressure (siblings)	0.8	1.2	3.9	-1.4	0.3	-2.0	0.1
Alcohol intake frequency.	0.8	1.9	8.2	-0.9	-0.6	-0.5	-2.9
Overall health rating	0.8	1.8	6.1	-2.5	-0.6	-1.5	-0.3
Had major operations	0.8	1.0	2.9	-0.9	-1.0	-1.7	-0.4
Smoking status: Previous	0.8	1.1	2.1	-1.5	-0.7	-1.4	1.0
Average weekly red wine intake	0.8	1.2	3.3	0.7	1.1	1.8	0.9
Osteoporosis (self-reported)	0.8	0.9	2.1	1.0	1.5	0.9	0.8
Myopia	0.8	1.1	2.8	1.7	0.4	1.3	-1.0
Mean Putamen Volume	0.7	0.8	2.3	-0.3	1.2	-0.6	1.5
HbA1C	0.7	0.7	1.4	-1.1	0.9	-0.5	1.2
Waist Hip Ratio (WHR)	0.7	3.2	10.1	-0.2	1.9	1.4	-3.2
Number of treatments/medications taken	0.7	1.2	2.6	-0.9	-1.6	-1.4	-0.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.7	-0.0	-1.0	0.4	-1.9
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.0	-1.1	1.4	1.3	-0.1
Medication: Metformin	0.7	1.0	2.5	-1.1	-0.9	-0.6	-1.6
Average weekly fortified wine intake	0.7	0.9	1.8	1.2	1.0	1.4	-0.0
Medication: Atenolol	0.7	0.9	2.0	0.9	-1.1	1.4	-0.6
Neuroticism score	0.7	1.4	4.6	0.0	0.3	1.5	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.7	1.3	0.5	1.0	-1.3
Eye problems/disorders: None of the above	0.7	0.8	1.4	1.0	0.7	1.2	-1.0
Medication: Allopurinol	0.7	0.9	3.3	-0.4	-0.7	-1.8	-0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.9	-0.9	0.1	-1.7	0.4
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.3	0.5	-0.8	-1.5	1.1
Friendships satisfaction	0.7	0.8	1.8	1.0	0.3	1.4	-1.1
Osteoarthritis (self-reported)	0.7	0.9	1.9	-1.4	1.1	-0.9	-0.7
Commuting to job workplace: Public transport	0.7	0.8	2.0	1.4	0.6	1.1	-0.7
Medication: Blood pressure	0.7	1.4	3.5	-1.9	1.7	0.1	-0.6
Bipolar Disorder (2018)	0.6	0.9	2.1	1.3	-0.7	-0.7	-1.4
Breast Cancer	0.6	1.5	3.4	-1.3	-1.1	-1.2	1.9
Bipolar Disorder (2011)	0.6	0.6	3.0	0.0	0.0	-1.7	-0.3
Neuroticism (2016)	0.6	0.8	2.3	-1.3	1.5	0.1	0.3
Schizophrenia (2014)	0.6	1.4	5.6	2.4	-0.7	0.2	0.9
Supplements: Zinc	0.6	0.7	2.3	0.1	0.7	0.7	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.2	-0.6	-0.8	-0.9	-1.5
Supplements: Glucosamine	0.6	0.8	1.9	1.4	-0.3	1.2	-0.6
Number of incorrect matches in round	0.6	1.0	1.8	-1.4	-0.9	-1.2	0.8
Illnesses of siblings	0.6	0.8	1.4	1.0	-1.2	1.0	0.9
Father’s age at death	0.6	0.8	2.4	0.9	0.3	0.9	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.0	0.1	1.4	1.0	-0.7
Breastfed as a baby	0.6	0.7	2.2	-1.5	-0.1	-1.0	0.6
Headache pain in last month	0.6	1.1	4.1	1.0	0.1	0.5	-2.0
Health satisfaction	0.6	0.8	2.4	-1.6	0.2	-1.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.7	1.0	1.3	0.1	1.0
Medication: Aspirin	0.6	0.7	1.1	-0.8	-0.9	-1.1	-1.0
Illnesses of siblings: Diabetes	0.6	0.7	2.1	0.3	-0.4	-1.2	-1.5
Mineral and other dietary supplements	0.6	0.8	1.8	-1.0	0.1	-1.0	-1.3
Illnesses of father: None of the above (group 1)	0.6	0.7	3.1	0.2	0.3	-0.5	1.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.9	-0.4	-1.2	-1.4	0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.0	1.0	1.0	1.4	0.2
Heart disease (siblings)	0.6	0.8	3.0	-1.7	0.7	-0.1	-0.5
Depressed Affect (Nagel 2018)	0.5	1.1	3.4	-0.6	-1.0	-1.0	-1.8
Lupus	0.5	0.7	1.4	0.1	1.1	1.0	1.2
Allergy or Eczema	0.5	1.2	4.0	-1.3	0.5	-0.5	2.0
Respiratory disease	0.5	1.1	3.3	-1.3	-1.8	-0.9	0.0
Neuroticism	0.5	1.3	6.5	0.0	-0.2	0.0	-2.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	2.4	-0.2	-0.3	-1.5	-0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.5	-1.2	-1.0	0.1	0.0
Qualifications: CSEs or equivalent	0.5	0.6	1.1	-0.9	-1.0	0.2	1.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.5	1.0	-0.8	-0.1	-1.2
Had menopause	0.5	0.7	1.5	1.2	1.2	0.3	-0.5
Qualifications: None of the above	0.5	1.0	2.3	-1.5	1.2	-1.1	0.1
Falls in the last year	0.5	0.7	2.0	1.4	0.2	1.0	-0.6
Happiness	0.5	0.6	1.4	-1.2	0.6	1.0	-0.4
Medication: Lansoprazole	0.5	0.5	2.6	-0.1	-0.1	-1.6	0.0
Exposure to tobacco smoke at home	0.5	0.5	1.1	-0.6	-1.0	-1.0	-0.5
Hair/balding pattern: Pattern 4	0.5	1.3	3.8	-0.9	-1.1	-1.9	0.9
Neck or shoulder pain in last month	0.5	0.7	1.7	-0.6	0.9	0.8	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.5	-0.8	-1.9	-0.9	0.7
Qualifications: nursing, teaching	0.5	0.7	1.8	1.2	-1.3	0.4	-0.1
Miserableness	0.5	0.8	2.8	-0.3	-0.8	-0.7	-1.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	-0.9	-0.9	-0.7	-1.0
Medication: Lisinopril	0.5	0.7	1.4	1.0	-0.7	0.6	-1.2
Ever smoked	0.5	0.9	3.2	-1.1	0.0	-1.8	0.3
Commuting to job workplace: Cycle	0.5	0.6	1.2	0.3	1.1	1.0	-1.0
Prostate Cancer	0.4	0.5	1.8	0.3	1.3	0.9	-0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.4	0.3	0.3	-0.7	-1.2
Blood Eosinophil Count	0.4	3.1	6.3	-2.3	-2.0	-2.5	-0.3
Heel T-Score	0.4	2.9	7.0	-2.6	-0.3	-1.6	2.2
Relative age of first facial hair	0.4	0.7	2.6	1.0	0.3	1.6	-0.3
Severe depression (siblings)	0.4	0.4	1.1	-0.8	0.5	0.0	-1.1
Taking other prescription medications	0.4	0.6	2.4	-1.6	-0.1	-0.8	0.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.2	-1.3	-0.2	-0.1	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.3	-0.9	-0.4	-0.8	1.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.2	0.2	0.1	1.5	0.5
Time employed in main current job	0.4	0.5	2.2	-0.4	1.5	0.1	-0.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	0.8	-0.7	0.4	1.2
Number of live births	0.4	0.6	2.3	-0.2	-0.4	-1.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.1	-1.5	-1.8	-0.3	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.7	-1.2	-2.2	-0.1	-1.0
Length of working week for main job	0.4	0.5	1.4	-0.8	0.5	0.2	-1.2
Peak expiratory flow (PEF)	0.4	1.0	1.8	-1.4	-1.0	0.7	-1.3
Gout (self-reported)	0.4	0.6	1.8	0.3	-0.3	-1.0	-1.4
Forced vital capacity (FVC), Best measure	0.4	1.3	4.9	-0.6	-2.2	0.1	-1.2
Worry too long after embarrassment	0.4	0.7	1.5	1.2	-1.0	0.9	-0.2
Supplements: Vitamin C	0.4	0.5	1.1	0.2	0.6	0.9	-1.0
Hypertension (Self-reported)	0.4	1.1	2.4	-1.6	0.1	-1.5	0.9
Mood swings	0.4	0.8	2.0	-0.8	-1.4	-1.0	-0.6
Number of self-reported non-cancer illnesses	0.4	0.7	1.5	-1.0	-1.0	-1.2	-0.4
Guilty feelings	0.4	0.5	2.6	0.3	0.1	-0.1	-1.6
Eye problems/disorders: Glaucoma	0.4	0.4	1.7	0.1	-0.7	-0.2	1.3
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	-0.4	-0.8	-1.1	0.6
Bipolar Disorder or Schizophrenia	0.3	0.6	1.4	1.2	-1.2	-0.6	-0.1
Reaction Time	0.3	0.5	1.0	-0.8	-0.6	-0.7	-1.0
Fasting Glucose	0.3	0.4	1.0	0.5	-1.0	-0.7	-0.6
Blood Platelet Count	0.3	3.0	6.1	1.9	-2.2	-2.5	0.9
Cardiovascular Disease	0.3	0.9	2.7	-0.7	-1.0	-1.6	-0.1
Lung FEV1/FVC ratio	0.3	1.3	3.6	-1.9	1.2	0.1	1.1
Maternal smoking around birth	0.3	0.5	1.7	-1.3	0.2	-0.1	0.9
High blood pressure	0.3	0.8	1.9	-1.1	0.2	-1.4	1.0
Nervous feelings	0.3	0.5	1.7	0.8	-0.0	1.3	-0.4
Forced vital capacity (FVC)	0.3	1.3	4.1	-0.7	-2.0	-0.0	-1.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	-1.0	0.0	-1.0	-0.0
Allergy	0.3	0.8	2.2	1.5	0.4	-0.3	-1.2
Glaucoma (self-reported)	0.3	0.4	1.0	-0.1	-1.0	0.4	0.8
Birth weight	0.3	0.6	1.5	1.2	-0.2	-1.2	0.5
Comparative body size at age 10	0.3	0.8	2.8	-0.9	0.5	0.1	-1.7
Shortness of breath walking on level ground	0.3	0.4	0.8	-0.6	0.9	-0.4	0.7
Medication for pain relief, constipation, heartburn	0.3	0.5	1.4	0.2	0.7	1.2	0.8
Migraine (self-reported)	0.3	0.3	0.9	-0.8	0.1	0.3	0.9
Suffer from ‘nerves’	0.3	0.5	1.5	-0.8	-0.2	0.7	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.6	-0.2	-0.5	-1.3	0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	1.0	-0.7	0.2	0.7
High cholesterol (Self-reported)	0.3	0.6	1.5	-1.1	-0.5	-1.2	0.1
Medication: Atorvastatin	0.3	0.4	0.9	-0.9	-0.6	-0.0	-0.8
Fractured/broken bones in last 5 years	0.3	0.3	1.2	-1.1	0.5	-0.3	-0.3
Depression (Nagel 2018)	0.2	0.3	0.5	-0.7	-0.5	-0.6	-0.5
Neuroticism (Nagel 2018)	0.2	0.6	1.4	-0.4	-1.0	-0.6	-1.2
Schizophrenia (2018)	0.2	0.5	1.0	0.6	-0.9	-0.2	1.0
Crohns Disease (2017)	0.2	0.5	1.9	1.4	-0.6	-0.7	-0.2
Crohns Disease (2012)	0.2	0.4	0.9	1.0	-0.8	-0.3	-0.3
Rheumatoid Arthritis	0.2	0.3	0.9	-0.1	-0.9	-0.2	0.9
Systolic Blood Pressure	0.2	1.0	2.5	-1.6	1.5	0.6	-0.1
Hypothyroidism (self reported)	0.2	0.5	2.1	0.0	-1.5	-0.4	0.6
Lung FVC	0.2	0.9	1.9	-0.9	-1.4	-0.6	-1.3
Multivitamins +/- minerals	0.2	0.2	0.6	0.6	-0.8	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.7	-0.5	0.8	-0.2	0.1
Standing height	0.2	1.6	4.6	1.3	-2.2	0.7	-1.1
Tense / ‘highly strung’	0.2	0.4	1.2	-1.1	-0.1	-0.8	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.0	-0.4	-1.0	0.1	0.6
Medication: Amlodipine	0.2	0.3	1.3	-1.1	0.1	0.3	-0.4
Mean time to correctly identify matches	0.2	0.3	0.8	-0.7	-0.3	-0.9	-0.4
Family relationship satisfaction	0.2	0.2	0.3	0.5	-0.2	0.6	0.6
Loneliness, isolation	0.2	0.3	1.5	0.1	-1.2	-0.3	0.1
Medication: Paracetamol	0.2	0.3	0.8	-0.7	0.3	-0.6	-0.9
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.9	0.9	0.2	0.9	-0.7
Worry (Nagel 2018)	0.1	0.2	0.6	-0.1	-0.0	0.6	-0.8
Alzheimer’s Disease (in mother)	0.1	0.2	0.8	-0.1	0.0	0.0	-0.9
LDL Cholesterol	0.1	0.1	0.5	-0.7	0.3	0.1	-0.2
Height	0.1	1.1	3.8	0.6	-1.3	1.9	0.0
Hair Pigment	0.1	3.2	7.4	-2.7	-1.1	-2.2	1.6
Tanning	0.1	1.4	4.5	0.3	2.1	1.2	-1.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	-0.6	0.1	-0.5	0.3
Medication for hormone replacement therapy	0.1	0.1	0.2	0.0	-0.3	0.5	0.5
Vitamin and mineral supplements	0.1	0.2	0.3	0.4	0.3	-0.5	-0.5
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.3	-0.5	-0.0	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.2	0.6	0.4	-0.4
Pain all over the body in last month	0.1	0.1	0.4	-0.6	0.1	0.0	-0.6
Medication: Paracetamol	0.1	0.2	0.8	-0.2	0.1	0.0	-0.9
Comparative height size at age 10	0.1	0.6	1.5	-0.4	0.2	1.2	-1.0
Medication: Gliclazide	0.1	0.1	0.2	-0.1	0.4	-0.5	-0.3
Wears glasses or contact lenses	0.1	0.1	0.3	-0.1	0.5	0.1	0.3
Medication: Bendroflumethiazide	0.1	0.2	0.5	0.7	0.2	0.1	0.5
Pain experienced in last month	0.1	0.1	0.3	0.2	0.3	0.5	0.4
Blood Red Count	0.0	0.4	1.4	-0.2	-1.2	-0.5	0.4
Ever had bowel cancer screening	0.0	0.0	0.1	0.2	0.2	0.2	-0.2
Mother’s age at death	0.0	0.1	0.1	0.2	0.3	0.3	0.3

Hub : Genes

ADARB1

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Trait associations