Best TWAS P=1.75e-11 · Best GWAS P=4.42e-12 conditioned to 0.0185
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TNRC6B | 0.02 | 0.01 | blup | 92 | 0.01 | 2.7e-03 | -5.8 | -6.6 | 5.3e-11 | 0.85 | 0.02 | 0.80 | FALSE |
2 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADSL | 0.04 | 0.03 | enet | 6 | 0.03 | 1.6e-04 | -6.9 | -6.2 | 5.0e-10 | 0.90 | 0.00 | 0.94 | FALSE |
3 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADSL | 0.07 | 0.02 | blup | 33 | 0.05 | 5.2e-04 | -3.8 | -5.7 | 9.5e-09 | 0.68 | 0.07 | 0.50 | FALSE |
4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TNRC6B | 0.05 | 0.03 | lasso | 8 | 0.04 | 6.9e-06 | -4.2 | -5.6 | 1.9e-08 | 0.54 | 0.78 | 0.07 | FALSE |
5 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADSL | 0.03 | 0.00 | blup | 33 | 0.01 | 8.9e-03 | -6.8 | -6.7 | 1.8e-11 | 0.84 | 0.01 | 0.61 | TRUE |
6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ADSL | 0.06 | 0.02 | lasso | 2 | 0.03 | 6.6e-03 | -6.9 | -6.6 | 3.3e-11 | 0.97 | 0.00 | 0.82 | FALSE |
7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADSL | 0.09 | 0.03 | lasso | 3 | 0.01 | 7.7e-02 | -6.9 | -6.6 | 2.9e-11 | 0.92 | 0.00 | 0.76 | FALSE |
8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ADSL | 0.04 | 0.00 | blup | 33 | 0.03 | 2.6e-03 | -3.8 | -6.3 | 3.4e-10 | 0.68 | 0.02 | 0.73 | FALSE |
9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MKL1 | 0.05 | 0.01 | blup | 95 | 0.02 | 2.2e-02 | 5.2 | -5.5 | 4.5e-08 | 0.47 | 0.01 | 0.90 | FALSE |