Hub : Genes

TNRC6B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1110	0.0500	5.8e-03	-0.005	NA	-0.003	NA	0.006	6.9e-01	NA	5.0e-01	NA	1.5e-01
2	GTEx	Brain Cerebellum	0.1300	0.0600	3.7e-03	0.139	NA	0.064	NA	0.091	6.7e-05	NA	5.8e-03	NA	1.2e-03
3	TCGA	Breast Invasive Carcinoma	0.0161	0.0085	1.6e-03	0.006	0.010	0.003	NA	0.004	1.5e-02	2.7e-03	7.5e-02	NA	4.5e-02
4	TCGA	Brain Lower Grade Glioma	0.0521	0.0249	4.5e-05	0.026	0.040	0.037	NA	0.045	4.8e-04	2.3e-05	4.7e-05	NA	6.9e-06
5	TCGA	Liver Hepatocellular Carcinoma	0.1350	0.0690	7.9e-03	-0.006	0.028	0.004	NA	-0.005	8.1e-01	1.7e-02	2.0e-01	NA	6.2e-01
6	TCGA	Pancreatic Adenocarcinoma	0.1240	0.0740	2.9e-03	0.051	0.004	0.018	NA	0.049	3.5e-03	2.1e-01	5.8e-02	NA	4.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.2	1.9	6.4	2.5	-0.8	0.6	-0.4	-1.1	-1.6
Bipolar Disorder or Schizophrenia	1.9	4.6	10.2	1.0	-1.9	-1.4	-2.3	-2.4	-3.2
Depressed Affect (Nagel 2018)	0.6	1.3	3.3	-0.1	1.8	1.8	0.8	0.2	0.9
Depression (Nagel 2018)	0.1	0.2	1.0	-1.0	0.1	0.3	0.2	0.1	-0.1
Intelligence (Savage-Jansen 2018)	1.3	3.9	9.7	3.1	-2.0	-1.3	0.5	1.6	-2.2
Neuroticism (Nagel 2018)	1.3	2.9	6.9	-0.2	2.6	2.6	0.9	-1.3	1.1
Schizophrenia (2018)	2.3	4.7	7.7	-0.7	-1.9	-2.2	-2.7	-2.2	-2.8
Schizophrenia vs Biploar Disorder	0.8	1.1	1.7	-1.0	-0.8	-1.3	-1.2	-1.3	-0.5
Worry (Nagel 2018)	2.7	5.7	11.8	0.8	3.3	3.4	2.1	-1.0	2.4
Alzheimer’s Disease (in mother)	1.7	2.0	5.0	1.0	1.6	2.2	0.9	-0.2	1.6
Alzheimer’s Disease (in father)	0.5	0.6	1.6	1.0	-0.7	-0.4	-0.5	0.0	-1.2
Alzheimer’s Disease (including proxy)	0.3	0.5	1.0	0.7	0.4	1.0	-0.6	-1.0	0.0
Crohns Disease (2017)	0.8	1.7	6.6	-1.1	0.3	0.2	-1.5	-2.6	0.0
Irritable Bowel Disease (IBD)	0.8	2.0	3.8	-0.1	1.9	1.9	-0.0	-1.9	0.8
Ulcerative Colitis (UC)	2.2	4.1	9.4	1.1	2.7	3.1	1.7	-0.5	1.9
Major Depression (MDD)	0.7	0.9	2.6	0.2	1.6	0.9	-0.6	-1.3	-0.2
Reaction Time	0.6	1.2	2.3	-1.1	1.4	0.8	-0.2	-1.5	1.0
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.8	1.9	-1.5	-0.4	0.1	0.7	-2.0
Breast Cancer	20.9	50.3	82.3	-1.9	-9.1	-8.7	-8.2	-2.5	-8.3
Ovarian Cancer	0.8	1.1	2.4	1.4	-0.6	0.3	0.9	1.6	0.9
Prostate Cancer	2.3	3.2	5.2	-1.8	1.8	-1.4	1.5	2.0	2.3
Age at First Birth	1.3	1.8	3.4	0.4	-1.4	-1.3	-1.2	-1.5	-1.8
Bipolar Disorder (2011)	0.7	0.7	2.1	1.4	-0.9	-0.1	-0.3	-0.1	-1.1
Body Mass Index (BMI) (2010)	3.1	4.2	7.4	-1.7	-1.2	-2.7	-2.3	-2.4	-1.6
Coronary Artery Disease (CAD)	0.2	0.2	0.6	0.2	0.8	-0.2	0.1	-0.1	-0.6
Crohns Disease (2012)	0.6	0.9	4.5	0.3	0.6	0.4	-0.6	-2.1	0.0
Mean Putamen Volume	0.3	0.4	1.0	1.0	-0.1	0.2	-0.4	0.8	-0.6
Fasting Glucose	0.6	0.8	1.9	-1.4	-0.2	-0.0	0.2	1.1	1.2
HbA1C	1.8	2.0	4.8	-1.1	-0.6	-0.5	-2.1	-2.2	-1.0
HDL Cholesterol	1.0	1.7	2.9	1.4	1.6	1.7	1.4	-0.5	0.9
LDL Cholesterol	1.3	2.0	4.0	-1.5	0.3	-1.2	-2.0	-2.0	-0.4
Lupus	1.0	1.6	3.3	1.0	1.5	1.8	1.4	0.6	0.9
Neuroticism (2016)	1.1	1.6	6.4	-0.4	-0.3	0.8	-1.5	-2.5	-0.3
Primary Biliary Cirrhosis	0.4	0.6	1.7	0.1	1.3	0.6	0.1	-1.1	0.5
Rheumatoid Arthritis	1.2	1.6	2.8	-1.7	1.5	1.5	0.8	-0.3	1.3
Schizophrenia (2014)	3.2	7.2	13.1	-0.0	-2.3	-2.3	-3.2	-3.0	-3.6
Triglycerides	0.2	0.3	1.0	-0.4	0.4	0.4	0.4	0.1	1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.2	-0.3	1.2	1.2	0.7	0.4	1.5
Ulcerative Colitis	1.5	2.1	5.0	1.6	1.6	2.2	0.7	-1.5	-0.4
Blood Eosinophil Count	2.0	15.7	25.3	-5.0	-4.0	-4.7	-4.5	-1.2	-3.1
Blood Platelet Count	0.1	0.9	1.4	1.0	-1.2	-1.2	-0.5	0.6	-0.9
Blood Red Count	0.7	6.5	14.5	3.8	0.8	3.5	2.7	1.8	0.8
Blood White Count	0.5	3.8	7.7	0.3	-1.9	-2.8	-2.4	0.4	-2.3
Heel T-Score	0.9	7.2	18.1	3.2	1.9	4.3	2.2	0.5	2.3
BMI	6.3	36.6	69.2	-6.7	-3.8	-8.3	-7.6	-2.7	-5.0
Height	0.2	4.6	18.1	4.3	-0.8	2.1	1.9	-0.8	0.2
Waist Hip Ratio (WHR)	0.1	0.3	1.2	-0.2	0.2	-0.3	-1.1	-0.6	0.1
Systolic Blood Pressure	3.1	15.8	34.4	2.5	3.4	3.6	5.9	5.0	2.2
Smoking Status	2.1	5.0	13.5	0.6	1.9	1.2	3.0	3.7	1.4
Allergy or Eczema	0.5	1.2	3.9	-0.0	1.4	1.1	0.0	-0.6	2.0
Cardiovascular Disease	0.6	1.8	5.4	-2.3	0.4	-2.1	-0.9	0.5	0.1
Hypothyroidism (self reported)	1.3	3.1	5.0	-2.2	-1.9	-1.7	-1.7	-1.3	-1.6
Respiratory disease	0.4	0.9	3.5	0.2	0.7	0.7	0.8	0.6	1.9
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.3	-1.1	0.3	0.1	-0.4	-0.7	0.9
Lung FEV1/FVC ratio	2.4	12.2	20.7	-1.2	-4.5	-4.2	-3.8	-0.8	-4.3
Lung FVC	0.6	2.9	7.0	2.6	-1.5	-0.0	1.9	2.1	-0.5
Neuroticism	0.8	2.0	5.7	0.3	1.6	2.4	1.3	-0.4	1.3
Chronotype (morning person)	4.0	9.2	18.4	-2.8	-1.4	-3.0	-4.3	-4.0	-1.4
Hair Pigment	0.2	6.1	9.5	0.6	2.8	2.7	2.6	2.2	3.1
Tanning	0.1	1.3	5.2	0.7	-0.6	0.6	-0.9	-2.3	-0.7
Hand grip strength (left)	1.8	4.7	12.0	0.4	-1.7	-3.4	0.0	3.5	-1.2
Number of treatments/medications taken	0.6	1.0	3.0	-1.7	1.2	0.5	0.5	0.4	1.0
Average weekly spirits intake	2.3	2.8	5.9	1.5	1.6	1.6	1.9	2.4	0.4
Sensitivity / hurt feelings	0.3	0.6	1.2	-0.9	-0.7	1.1	-0.1	-0.9	0.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.7	-0.4	-0.1	0.5	1.1	1.9	0.7
Hearing difficulty/problems: Yes	0.1	0.2	0.5	0.7	0.1	0.2	0.1	0.3	0.6
Relative age of first facial hair	1.3	2.8	5.2	2.3	0.3	1.9	1.9	1.0	1.6
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	6.7	-2.6	-0.0	-0.9	-1.1	-1.0	-0.5
Ever used hormone-replacement therapy (HRT)	1.2	1.5	4.2	-0.6	1.3	0.1	1.4	2.0	1.0
Ever had hysterectomy (womb removed)	2.7	3.1	7.4	0.4	2.7	2.2	1.5	0.0	2.0
Systolic blood pressure, automated reading	2.0	5.7	13.1	0.7	2.6	1.2	3.0	3.6	1.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.4	0.2	-0.1	-1.2	-1.2	-1.8	0.1
Angina	0.6	0.8	2.0	0.5	0.7	0.4	1.1	1.4	-0.8
Medication for hormone replacement therapy	3.1	3.5	6.2	0.9	1.1	1.5	2.5	2.3	2.3
Vitamin and mineral supplements	2.8	3.8	19.9	-0.5	-0.4	-1.0	1.2	4.5	0.5
Supplements: Zinc	0.2	0.2	0.4	0.6	0.1	0.4	0.3	-0.6	0.4
Medication: Co-codamol	1.0	1.2	4.0	0.5	-1.4	-0.7	0.1	2.0	-0.7
Medication: Metformin	0.3	0.5	2.2	-1.5	0.4	-0.1	-0.3	-0.5	0.2
Diabetes (father)	0.3	0.4	1.3	0.0	-0.1	-0.5	-1.1	-0.8	0.2
Diabetes (mother)	0.7	0.9	3.6	-1.9	0.2	-1.2	-0.4	0.2	-0.6
Severe depression (siblings)	1.2	1.3	2.9	0.3	-1.2	-1.3	-1.3	0.5	-1.7
Pack years adult smoking proportion	0.7	1.0	4.0	0.3	-0.1	0.4	1.3	2.0	0.4
Impedance of leg (right)	4.6	22.1	52.6	4.2	3.8	7.3	4.9	1.8	4.6
Leg fat-free mass (left)	2.1	11.1	23.6	-2.7	-2.8	-4.9	-3.4	-1.1	-3.9
Trunk fat percentage	0.6	2.2	6.5	-1.3	0.9	-1.4	-2.6	-1.3	-0.4
Hand grip strength (right)	0.9	2.4	8.8	0.7	-1.1	-1.7	0.6	3.0	-0.8
Townsend deprivation index at recruitment	2.5	3.5	6.2	-0.9	-2.5	-2.1	0.2	2.3	-2.2
Current tobacco smoking	2.6	4.2	8.7	1.0	0.9	2.1	2.8	2.9	1.6
Average weekly fortified wine intake	0.2	0.3	0.6	-0.3	0.8	0.6	0.5	0.4	0.4
Maternal smoking around birth	0.4	0.6	1.7	-0.3	0.9	-1.0	0.1	1.3	-0.4
Fed-up feelings	0.5	0.9	2.1	-0.1	-1.3	-0.9	-0.8	0.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.6	-0.6	-0.9	0.0	0.4	1.2	-1.0
Relative age voice broke	0.3	0.5	1.1	0.7	-1.0	0.7	0.7	0.3	0.5
Taking other prescription medications	1.3	2.0	3.6	0.3	1.3	1.9	1.6	0.6	1.8
Age when periods started (menarche)	1.0	2.3	4.2	2.1	1.9	1.8	1.3	-0.1	1.0
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.2	1.0	2.3	2.0	0.6	-0.2	1.7
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.2	8.1	2.8	2.2	2.6	2.6	2.1	2.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.8	-1.1	-0.5	-1.3	-0.2	1.4	-0.7
Qualifications: CSEs or equivalent	1.3	1.7	3.7	-0.7	1.1	1.9	1.1	0.2	1.9
Serious illness, injury or assault to yourself	1.6	2.0	4.6	2.1	1.8	1.3	1.3	-0.1	0.9
High blood pressure	0.7	2.0	5.6	-1.7	0.4	-2.4	-1.1	1.2	-0.7
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.3	-1.3	1.6	0.8	-0.2	0.2	1.8
Multivitamins +/- minerals	3.2	4.1	19.3	-1.2	0.1	0.5	-1.7	-4.4	-0.9
Stomach or abdominal pain in last month	0.4	0.5	1.0	0.9	-0.9	-0.1	0.1	0.8	-1.0
Supplements: Glucosamine	0.5	0.6	2.0	-1.4	-0.8	-0.5	-0.7	-0.4	0.3
Diverticular disease/diverticulitis (self-reported)	2.0	2.3	5.7	1.7	0.2	1.2	1.9	2.4	0.5
Medication: Atenolol	0.6	0.7	2.1	-0.2	-1.2	0.2	-0.6	-0.4	-1.5
Medication: Levothyroxine sodium	0.8	1.4	5.2	-2.3	-0.6	-1.4	-0.7	0.2	-0.4
Sitting height	0.2	1.3	4.0	2.0	-1.5	0.3	0.7	0.1	-0.8
Chronic bronchitis/emphysema (father)	0.8	0.9	2.0	-1.2	0.4	-0.5	-1.1	-1.4	0.5
High blood pressure (mother)	0.6	0.9	4.0	-2.0	0.6	-0.5	-0.8	-0.1	-0.3
Body mass index (BMI)	4.7	20.1	43.1	-4.5	-2.4	-6.6	-5.6	-1.3	-4.3
Impedance of leg (left)	4.3	20.7	46.5	4.4	3.6	6.8	4.4	1.6	4.8
Leg predicted mass (left)	2.2	11.4	24.1	-2.8	-2.9	-4.9	-3.5	-1.1	-3.9
Trunk fat mass	1.0	4.5	10.7	-1.9	-0.2	-2.9	-3.3	-1.3	-1.6
Waist circumference	3.5	12.7	25.8	-3.8	-1.4	-5.1	-4.8	-1.3	-3.0
Number of incorrect matches in round	1.0	1.6	4.2	-2.0	0.6	-1.1	-1.5	-1.1	0.5
Past tobacco smoking	0.8	1.4	2.9	0.3	-1.7	-1.1	-1.2	-1.2	-1.1
Alcohol usually taken with meals	1.3	2.1	8.1	-0.2	1.7	0.7	-0.4	-2.8	1.0
Nervous feelings	1.6	2.9	7.3	0.5	2.6	2.7	1.3	-0.7	1.2
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.7	7.1	-0.2	2.7	2.2	2.1	1.5	1.9
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.4	0.8	-0.4	-0.5	-0.1	0.8
Hair/balding pattern: Pattern 2	0.7	0.9	2.9	-0.4	-1.2	-0.9	0.1	1.7	-0.5
Had menopause	1.3	1.7	6.8	-1.0	0.9	-0.9	0.7	2.6	0.4
Had other major operations	2.3	2.8	12.2	-3.5	1.0	1.3	0.6	-0.3	1.1
Forced vital capacity (FVC)	0.7	2.6	6.3	2.5	-0.6	1.0	2.5	1.3	0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	7.0	2.1	2.6	2.2	1.3	-0.0	1.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.2	-0.3	-0.5	0.2	0.9	1.5	0.3
Qualifications: None of the above	0.3	0.5	1.7	-0.6	1.3	0.6	0.3	-0.2	0.8
Financial difficulties in last 2 years	0.6	0.8	3.3	0.0	0.2	-0.3	0.6	1.8	0.9
Mouth/teeth dental problems	2.0	3.0	6.2	-1.6	-1.0	-1.3	-2.4	-2.5	-0.8
Heart attack	1.7	2.1	7.0	-0.3	-1.8	-1.1	-1.0	0.0	-2.7
Allergy	0.6	1.5	3.5	1.3	-1.4	-1.1	-0.2	-0.5	-1.9
Pain all over the body in last month	1.3	1.4	3.4	-0.5	0.8	1.8	1.2	-0.6	1.6
Diabetes (self-reported)	0.3	0.5	2.3	-0.7	0.3	-0.1	-0.2	-1.5	-0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.8	-0.9	0.3	-0.3	0.2	0.9	1.4
Medication: Ramipril	0.3	0.4	1.6	0.7	-0.6	-1.3	-0.2	0.0	-0.1
Medication: Simvastatin	0.6	0.8	3.3	-1.0	-0.5	-1.8	-0.1	0.4	-0.3
Fluid intelligence score	1.5	3.0	6.3	2.5	-2.0	-1.1	-0.5	0.5	-2.5
Illnesses of siblings	0.7	1.0	1.8	-0.7	1.2	0.7	0.1	-1.3	1.3
Neuroticism score	0.5	1.1	3.6	0.2	1.0	1.9	1.0	0.3	0.9
Weight	2.5	12.4	28.1	-3.0	-2.4	-5.3	-4.2	-0.9	-3.6
Impedance of arm (right)	6.1	28.4	66.3	5.0	4.4	8.1	5.3	-0.2	5.6
Arm fat percentage (right)	2.3	9.0	20.0	-2.9	-0.7	-3.8	-4.5	-2.1	-2.5
Trunk fat-free mass	2.4	13.6	27.4	-2.8	-3.6	-5.2	-3.4	-0.6	-4.7
Hip circumference	1.0	4.5	9.4	-2.6	0.0	-3.1	-2.7	-0.7	-1.8
Time employed in main current job	1.1	1.2	3.3	-1.3	-0.6	-1.8	-0.9	-0.4	-1.0
Alcohol intake versus 10 years previously	1.1	1.7	4.3	2.1	0.5	1.6	1.6	0.1	0.5
Father’s age at death	0.7	0.9	2.3	1.1	-0.0	0.6	1.5	1.0	0.8
Worrier / anxious feelings	0.7	1.3	3.4	0.1	1.8	1.8	0.8	-0.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.0	1.1	-0.8	1.0	1.6	1.7	0.1
Falls in the last year	4.3	5.8	9.9	0.5	2.4	2.6	2.9	2.0	3.1
Hair/balding pattern: Pattern 3	0.6	0.9	2.7	1.7	0.1	1.1	0.3	-1.1	0.2
Number of live births	3.8	5.4	11.3	0.7	1.8	2.0	3.4	3.3	1.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	3.7	1.9	-1.2	0.2	1.5	1.2	-0.2
Pulse rate	0.8	1.4	2.3	0.9	-1.5	-1.5	-1.1	-0.3	-1.4
Happiness	1.7	2.0	4.2	-1.1	-2.0	-1.7	-0.9	0.9	-1.5
Noisy workplace	0.3	0.4	1.1	-0.4	-0.3	0.4	0.6	-0.8	1.1
Qualifications: A levels/AS levels or equivalent	0.8	1.9	5.9	-0.3	-2.4	-1.2	-1.2	-0.9	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.1	0.4	1.3	1.4	1.4	0.6	1.2
Mouth/teeth dental problems: Dentures	0.6	1.1	3.2	-0.6	0.4	0.4	1.4	1.8	0.7
Asthma	0.3	0.5	1.7	0.3	0.4	0.4	0.5	1.3	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	4.0	1.6	1.5	2.0	1.1	-0.0	0.5
Medication: Cholesterol lowering	0.4	0.7	2.2	-1.0	-0.8	-1.5	-0.4	0.4	-0.3
Depression (self-reported)	0.6	0.7	1.7	0.8	1.2	1.3	0.5	-0.1	-0.2
Medication: Lansoprazole	0.7	0.8	1.7	0.9	0.4	1.3	1.3	0.8	-0.0
Prospective memory result	0.4	0.4	1.3	-1.1	0.1	-0.3	-0.4	0.2	1.0
Lung cancer (father)	0.3	0.4	1.0	0.4	-0.1	-0.4	0.3	1.0	-0.9
Illnesses of mother	0.6	0.8	2.4	1.6	-0.6	1.1	0.7	-0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	5.3	2.3	-1.0	-0.2	0.7	1.2	-0.7
Pulse wave Arterial Stiffness index	1.6	1.9	4.0	-0.3	-2.0	-1.5	-1.3	-0.8	-1.7
Impedance of arm (left)	7.4	34.3	82.8	4.9	5.1	9.1	5.5	-0.4	6.5
Arm fat mass (right)	3.0	12.5	24.2	-3.4	-1.4	-4.9	-4.8	-1.7	-3.3
Trunk predicted mass	2.5	14.2	28.3	-2.8	-3.8	-5.3	-3.4	-0.6	-4.8
Standing height	0.3	3.0	6.2	2.5	-0.0	2.3	2.3	0.1	1.1
Length of working week for main job	1.2	1.3	3.5	-0.3	0.1	-1.9	-1.6	-1.2	0.1
Exposure to tobacco smoke at home	2.4	2.7	8.1	-0.2	1.1	0.5	2.2	2.8	1.4
Breastfed as a baby	1.1	1.3	3.2	1.8	-0.8	0.3	1.1	1.5	0.8
Tense / ‘highly strung’	1.0	1.6	3.2	0.8	1.5	1.7	0.8	-0.3	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.4	10.5	1.4	2.0	3.0	3.2	1.7	2.1
Hair/balding pattern: Pattern 4	0.7	1.6	6.5	-2.5	0.2	-1.6	-0.5	0.3	0.5
Birth weight of first child	0.1	0.2	0.7	-0.9	-0.3	-0.3	-0.1	-0.3	0.3
Peak expiratory flow (PEF)	0.2	0.4	1.0	-0.1	-1.0	-0.7	-0.2	0.6	-0.8
Pulse wave reflection index	1.8	2.2	3.6	-0.6	-1.6	-0.9	-1.9	-1.7	-1.8
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.6	-0.9	0.6	1.6	1.5	0.6	1.2
Loud music exposure frequency	0.5	0.6	1.6	0.1	-0.1	0.9	0.9	-0.1	1.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.7	0.2	-0.0	1.5	1.9	1.2	1.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.9	0.3	0.3	-0.1	0.4	0.9	0.2
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.7	0.2	0.8	0.2	-0.9	0.3
Medication: Paracetamol	0.5	0.9	3.3	-1.3	0.1	1.8	0.5	-0.5	0.1
Headache pain in last month	1.2	2.1	7.5	1.6	1.1	2.7	1.1	-0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.8	0.7	0.3	1.3	1.0	0.9	0.1
Glaucoma (self-reported)	3.0	3.6	4.9	1.6	1.5	2.0	2.2	2.1	1.8
Gout (self-reported)	0.5	0.7	1.5	-1.2	0.8	-0.1	-0.4	-1.2	0.9
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	5.2	-2.3	-1.3	-1.4	-1.1	-0.2	-0.7
Medication: Amlodipine	3.1	4.3	8.7	-1.8	-0.7	-3.0	-2.9	-0.6	-2.2
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.2	1.1	-0.9	0.0	-0.1	-0.0	0.1
Birth weight	1.3	2.8	7.8	-0.9	-1.8	-1.9	-1.0	-0.4	-2.8
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	0.5	-1.1	-0.2	-0.8	-0.2	-0.5
High blood pressure (siblings)	0.5	0.7	1.3	-0.0	-0.9	-1.1	-0.9	0.3	-1.0
Forced vital capacity (FVC), Best measure	0.7	2.7	6.9	2.6	0.0	1.0	2.2	1.8	0.3
Body fat percentage	1.0	4.0	10.9	-2.0	0.2	-2.5	-3.3	-1.1	-1.3
Leg fat percentage (right)	1.8	6.5	13.8	-2.4	-0.6	-3.7	-3.7	-0.2	-2.3
Arm fat-free mass (right)	3.0	15.4	33.2	-3.2	-3.4	-5.8	-4.0	-0.4	-4.6
Exposure to tobacco smoke outside home	1.6	2.1	7.1	-0.2	0.8	0.6	1.5	2.7	1.4
Comparative body size at age 10	4.5	12.5	30.4	-4.2	-1.2	-5.5	-3.8	-1.3	-3.2
Number of full brothers	2.0	2.6	6.1	0.6	1.6	1.9	2.5	1.5	0.7
Worry too long after embarrassment	0.6	0.9	2.7	-1.6	1.0	1.0	-0.2	-0.9	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	4.4	1.3	1.8	2.1	1.5	0.5	1.7
Wheeze or whistling in the chest in last year	1.1	2.0	3.7	-1.9	1.7	1.0	1.1	1.1	1.3
Number of children fathered	0.5	0.5	1.3	1.2	1.1	-0.4	-0.4	-0.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.9	-0.1	-0.1	-0.9	-0.1	-0.0	-0.2
Age at first live birth	2.7	4.9	9.3	-1.9	-1.7	-2.5	-3.1	-1.2	-2.4
Pulse wave peak to peak time	1.9	2.3	4.2	0.6	2.1	1.7	1.5	0.9	1.8
Health satisfaction	0.6	0.8	2.7	0.3	1.6	0.7	0.1	-0.8	1.1
Shortness of breath walking on level ground	3.3	3.9	8.8	-0.1	1.8	2.0	2.1	1.7	3.0
Qualifications: College or University degree	1.1	3.5	5.2	0.7	-2.3	-2.0	-2.0	-1.7	-2.1
Eye problems/disorders: None of the above	0.5	0.6	1.6	-0.9	-0.6	0.1	-0.5	-1.3	0.8
Mouth/teeth dental problems: Loose teeth	3.0	3.6	8.4	0.5	0.9	1.6	2.4	2.9	1.8
Emphysema/chronic bronchitis	1.0	1.1	2.4	-0.6	1.5	1.5	0.9	-0.3	0.9
Medication for pain relief, constipation, heartburn	2.0	3.4	10.0	-1.4	-1.5	-3.2	-2.2	-0.2	-0.9
Neck or shoulder pain in last month	1.5	2.1	3.8	1.9	1.3	1.9	1.5	0.5	1.1
Medication: Blood pressure	0.3	0.5	1.4	-0.7	0.2	-1.2	-0.9	-0.3	-0.2
Angina (self-reported)	0.6	0.8	2.1	0.6	0.8	0.4	1.1	1.4	-0.7
Migraine (self-reported)	1.8	2.3	10.9	3.3	-0.8	1.2	0.3	-0.6	-0.5
Medication: Ibuprofen	1.8	2.2	6.0	1.0	1.8	2.5	1.3	-0.2	0.9
Medication: Allopurinol	0.6	0.9	3.8	-0.6	-0.0	-0.2	-0.9	-1.9	0.1
Medication: Omeprazole	1.6	1.9	4.2	2.0	0.8	1.7	1.4	1.0	0.9
Medication: Seretide 50 evohaler	0.5	0.5	1.3	-1.1	-0.2	0.8	0.2	0.0	1.1
Mean time to correctly identify matches	1.0	2.0	4.5	-2.1	1.8	0.6	0.1	-1.4	1.3
Heart disease (mother)	1.0	1.2	3.8	-0.4	0.7	-1.6	0.1	2.0	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	4.2	0.7	1.2	2.1	1.4	-0.9	1.7
Whole body fat mass	1.9	7.8	16.1	-2.7	-0.9	-4.0	-4.0	-1.1	-2.4
Leg fat mass (right)	2.7	10.6	23.6	-3.1	-1.5	-4.9	-4.3	-0.5	-3.1
Arm predicted mass (right)	2.8	14.4	31.2	-2.9	-3.3	-5.6	-3.9	-0.4	-4.5
Pulse rate, automated reading	0.2	0.5	1.1	-0.3	-0.7	-0.8	-0.9	0.5	-1.0
Alcohol intake frequency.	0.1	0.3	0.5	0.5	-0.6	0.7	-0.4	-0.6	-0.5
Comparative height size at age 10	0.5	2.6	7.1	1.0	1.5	2.7	1.6	0.1	1.7
Number of full sisters	0.9	1.2	4.2	-0.6	0.5	0.4	1.3	2.1	0.6
Suffer from ‘nerves’	3.3	5.2	9.1	1.4	2.3	2.7	3.0	1.6	2.2
Overall health rating	0.1	0.2	0.7	-0.1	0.4	0.5	0.2	0.4	-0.8
Chest pain or discomfort	0.3	0.5	1.6	0.3	-0.2	0.4	0.8	1.3	-0.6
Had major operations	1.6	1.8	8.8	3.0	0.1	1.3	0.4	-0.2	-0.5
Age at last live birth	0.6	0.9	1.5	-0.9	-0.6	-1.1	-1.1	0.2	-1.2
Family relationship satisfaction	1.8	2.2	4.1	-0.7	-1.7	-2.0	-1.3	-0.6	-1.9
Leg pain on walking	0.9	1.2	3.5	-0.6	1.9	0.7	1.0	0.7	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	-0.3	1.3	-0.1	-1.0	-1.1	-0.6
Commuting to job workplace: Car/motor vehicle	1.5	1.8	4.8	0.4	1.2	2.2	1.3	-0.4	1.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	0.7	-0.5	-0.6	-0.0	0.4	-0.0
Medication: Aspirin	0.5	0.7	1.3	0.8	0.5	0.9	1.1	1.0	0.3
Supplements: Vitamin C	1.1	1.3	4.2	1.4	0.4	1.3	-0.0	-2.0	-0.1
Knee pain experienced in last month	0.2	0.3	1.6	-0.1	-1.3	-0.3	-0.4	-0.3	-0.3
Hypertension (Self-reported)	0.8	2.1	6.1	-1.8	0.3	-2.5	-1.1	1.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	4.4	1.1	1.6	1.9	2.1	1.2	2.0
Illnesses of father: Heart disease	1.3	1.8	3.9	-0.4	-1.1	-1.1	-1.7	-1.4	-2.0
Illnesses of siblings: Diabetes	0.4	0.4	1.1	-0.5	-1.1	-0.2	-0.5	0.9	-0.2
Smoking status: Previous	0.3	0.5	1.5	-0.1	1.2	0.3	0.6	0.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.3	-0.4	-0.5	-0.2	0.0	0.6	0.3
Whole body fat-free mass	2.6	14.8	30.5	-3.0	-3.5	-5.5	-3.8	-0.9	-4.7
Leg fat-free mass (right)	2.2	11.8	26.3	-2.6	-3.0	-5.1	-3.5	-1.0	-3.8
Arm fat percentage (left)	2.0	7.9	18.3	-2.9	-0.6	-3.5	-4.3	-2.0	-2.1
Average weekly red wine intake	1.2	1.8	5.2	-2.0	-0.7	-2.3	-1.0	-0.2	-0.1
Handedness (chirality/laterality): Left-handed	5.2	6.3	14.1	0.8	-3.1	-3.8	-2.4	0.3	-2.7
Mood swings	0.3	0.6	1.4	-0.2	1.2	1.0	-0.0	-0.1	1.0
Loneliness, isolation	0.3	0.4	0.8	-0.1	-0.3	0.8	0.9	0.9	-0.3
Long-standing illness, disability or infirmity	0.6	1.0	2.6	-1.6	-1.2	-0.5	-0.6	-0.7	-0.7
Ever had bowel cancer screening	0.3	0.4	1.2	-0.7	0.3	1.1	0.1	-0.2	0.8
Diabetes diagnosed by doctor	0.3	0.5	1.5	-0.7	0.7	0.5	0.0	-1.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	3.3	-0.7	-1.8	-0.8	-0.9	-0.0	-1.5
Friendships satisfaction	3.8	4.7	6.9	-1.9	-2.6	-2.2	-2.6	-1.3	-2.2
Qualifications: nursing, teaching	0.3	0.4	1.2	-0.7	-1.1	-0.5	-0.3	0.4	-0.3
Commuting to job workplace: Walk	0.3	0.3	0.8	0.2	0.7	-0.2	0.8	0.9	0.3
Eye problems/disorders: Cataract	0.6	0.7	1.3	1.1	1.1	0.9	0.5	0.8	-0.3
Mouth/teeth dental problems: Mouth ulcers	3.8	6.0	10.9	3.3	2.5	2.9	2.7	0.7	1.7
Medication for cholesterol	0.7	1.1	4.4	0.2	-1.1	0.5	-0.7	-2.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.8	0.4	1.0	1.7	1.5	1.0	0.8
Back pain experienced in last month	0.9	1.4	4.6	2.1	-0.7	1.0	1.3	0.4	-0.5
Mineral and other dietary supplements	0.6	0.8	3.0	0.3	-0.7	-0.6	0.4	1.7	-0.7
Breast cancer (self-reported)	7.7	9.1	17.9	-0.3	4.2	3.6	2.6	-0.7	4.1
Asthma (self-reported)	0.2	0.5	2.1	0.3	0.2	0.1	0.4	1.5	0.6
Osteoporosis (self-reported)	0.8	1.0	2.2	0.0	-0.7	-1.2	-1.5	-0.6	-1.2
Osteoarthritis (self-reported)	0.7	0.9	1.9	1.3	0.8	0.9	0.5	0.6	1.4
Medication: Aspirin	0.4	0.6	1.3	0.7	0.4	0.6	1.1	1.1	0.0
Medication: Gliclazide	0.7	0.8	2.0	-1.4	-0.4	-0.5	-1.1	-1.0	-0.1
Illnesses of father: None of the above (group 1)	0.5	0.7	3.1	0.2	0.3	-0.0	0.6	1.8	0.5
Smoking status: Current	1.8	2.8	6.5	0.7	0.6	1.7	2.4	2.5	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.5	1.0	-0.2	-1.3	0.5	1.6	-0.2
Whole body water mass	2.7	15.2	31.2	-3.0	-3.6	-5.6	-3.8	-0.9	-4.8
Leg predicted mass (right)	2.2	11.6	25.5	-2.7	-3.0	-5.1	-3.5	-1.1	-3.8
Arm fat mass (left)	3.2	13.3	25.0	-3.6	-1.6	-5.0	-5.0	-1.9	-3.3
Number of self-reported non-cancer illnesses	0.2	0.4	1.3	-1.1	-0.2	0.4	0.1	0.6	0.6
Average weekly champagne plus white wine intake	1.3	1.7	8.5	0.2	0.4	0.5	-1.2	-2.9	0.4
Miserableness	0.9	1.5	3.4	1.0	0.4	1.9	1.4	1.3	0.9
Guilty feelings	1.4	2.1	4.1	1.8	1.6	2.0	1.5	-0.6	0.5
Wears glasses or contact lenses	0.6	0.7	1.2	1.0	0.8	0.2	-0.4	-1.1	-1.0
Ever taken oral contraceptive pill	1.8	2.0	3.0	1.3	1.7	1.1	1.5	1.6	1.1
Hearing aid user	0.2	0.3	0.5	0.5	0.7	-0.2	-0.2	-0.6	0.7
Mother’s age at death	0.3	0.4	0.8	-0.9	0.7	-0.7	0.4	0.6	0.1
Financial situation satisfaction	1.2	1.4	2.8	-0.4	-1.7	-1.7	-1.6	0.0	-0.5
Tinnitus: Yes, now most or all of the time	2.9	3.4	5.9	2.4	1.4	2.2	2.4	0.9	1.2
Commuting to job workplace: Public transport	0.4	0.5	1.5	-0.0	-0.6	-1.0	0.0	1.2	-0.5
Eye problems/disorders: Glaucoma	3.1	3.7	6.3	1.7	1.8	2.0	2.5	2.1	1.2
Medication: Blood pressure	1.5	2.9	7.5	-1.7	-0.1	-2.7	-1.7	0.5	-1.9
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.3	-0.4	-0.1	-0.3	0.4	0.5
Supplements: Fish oil (including cod liver oil)	1.0	1.4	5.7	-0.3	-0.2	0.1	-1.5	-2.4	-0.3
High cholesterol (Self-reported)	0.5	0.8	3.2	-1.8	-0.3	-1.3	-0.2	-0.0	0.4
Medication: Bendroflumethiazide	0.3	0.4	1.4	0.1	0.1	-1.2	-0.6	-0.5	-0.5
Medication: Paracetamol	0.9	1.4	4.0	-1.6	0.7	2.0	0.8	-0.5	0.7
Medication: Lisinopril	0.3	0.4	1.3	-0.6	0.3	-0.4	-0.2	1.2	-0.5
Medication: Atorvastatin	0.5	0.7	2.5	-0.5	1.6	0.3	0.7	0.3	0.8
Illnesses of father: High blood pressure	0.5	0.6	1.5	0.6	-0.4	-0.9	0.5	1.2	-0.9
Alcohol drinker status: Never	1.9	2.3	6.1	-1.0	-1.2	-2.5	-0.5	1.9	-1.1
Ever smoked	0.9	1.6	2.2	0.3	1.4	1.5	1.3	1.2	1.4
Basal metabolic rate	2.6	14.2	29.8	-3.0	-3.2	-5.5	-3.9	-1.0	-4.5
Leg fat percentage (left)	2.0	7.1	16.1	-2.4	-0.6	-4.0	-4.0	-0.3	-2.2
Arm fat-free mass (left)	3.4	17.3	37.3	-2.9	-3.7	-6.1	-4.3	-0.6	-5.0
Number of operations (self-reported)	1.2	1.7	4.8	-0.6	1.9	2.2	0.5	-0.7	1.0
Average weekly beer plus cider intake	0.8	1.1	2.6	-0.4	0.7	1.3	1.4	1.6	0.0
Irritability	0.4	0.7	1.4	-0.6	-0.7	-0.6	-1.2	-0.5	-1.0
Risk taking	1.2	1.7	2.9	-1.7	-0.1	-0.3	-1.6	-1.6	1.5
Ever had prostate specific antigen (PSA) test	3.8	4.3	8.9	-1.5	-1.4	-2.0	-3.0	-2.8	-1.0
Fractured/broken bones in last 5 years	0.3	0.4	0.7	0.5	0.8	0.6	0.3	-0.8	0.2
Age started oral contraceptive pill	0.4	0.5	1.3	-1.1	0.0	-1.1	-0.5	-0.5	-0.0
Diastolic blood pressure, automated reading	4.8	15.0	27.8	-1.5	-4.8	-5.3	-3.7	0.5	-4.9
Ever depressed for a whole week	2.5	3.1	7.1	-0.1	1.2	1.4	2.7	2.2	1.9
Unable to work because of sickness or disability	0.3	0.4	1.0	0.1	0.2	0.8	0.9	1.0	-0.2
Commuting to job workplace: Cycle	1.9	2.2	6.2	-1.4	-0.5	-2.5	-1.7	-1.4	-0.4
Myopia	0.6	0.9	2.9	-0.0	-0.6	-1.4	0.3	1.7	-0.5
Vascular/heart problems diagnosed by doctor	0.6	1.5	4.4	1.1	-0.1	2.1	0.9	-1.1	1.2
Cholesterol lowering medication	0.2	0.3	1.2	-0.7	1.1	-0.1	0.3	-0.0	0.3
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.4	1.9	0.9	1.8	1.7	0.6	1.4
Pain experienced in last month	0.7	1.1	3.5	-1.9	0.5	-1.2	-0.9	-0.6	0.5
Supplements: Calcium	0.7	0.8	3.4	0.9	-0.2	0.1	-0.6	-1.8	-0.2
Basal cell carcinoma (self-reported)	0.6	0.7	2.1	-0.3	0.7	-0.4	0.5	1.0	-1.4
Heart attack/myocardial infarction (self-reported)	1.5	1.9	6.1	-0.3	-1.8	-1.1	-0.9	0.3	-2.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.9	0.3	0.8	0.5	-0.5	0.5
Heart disease (siblings)	1.5	1.8	5.2	2.3	-0.6	0.0	0.8	2.0	-0.8
Alcohol drinker status: Previous	0.6	0.7	3.1	0.1	-0.2	1.8	1.1	0.1	0.1
Pack years of smoking	0.4	0.6	2.0	0.1	-0.1	0.6	1.0	1.4	0.3
Impedance of whole body	6.4	32.8	77.2	5.1	4.8	8.8	5.5	0.5	6.4
Leg fat mass (left)	2.8	10.8	24.9	-3.0	-1.5	-5.0	-4.4	-0.5	-3.0
Arm predicted mass (left)	3.3	16.8	36.5	-2.9	-3.5	-6.0	-4.2	-0.7	-5.0