Hub : Genes

TNRC6B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.1110 0.0500 5.8e-03 -0.005 NA -0.003 NA 0.006 6.9e-01 NA 5.0e-01 NA 1.5e-01
2 GTEx Brain Cerebellum 0.1300 0.0600 3.7e-03 0.139 NA 0.064 NA 0.091 6.7e-05 NA 5.8e-03 NA 1.2e-03
3 TCGA Breast Invasive Carcinoma 0.0161 0.0085 1.6e-03 0.006 0.010 0.003 NA 0.004 1.5e-02 2.7e-03 7.5e-02 NA 4.5e-02
4 TCGA Brain Lower Grade Glioma 0.0521 0.0249 4.5e-05 0.026 0.040 0.037 NA 0.045 4.8e-04 2.3e-05 4.7e-05 NA 6.9e-06
5 TCGA Liver Hepatocellular Carcinoma 0.1350 0.0690 7.9e-03 -0.006 0.028 0.004 NA -0.005 8.1e-01 1.7e-02 2.0e-01 NA 6.2e-01
6 TCGA Pancreatic Adenocarcinoma 0.1240 0.0740 2.9e-03 0.051 0.004 0.018 NA 0.049 3.5e-03 2.1e-01 5.8e-02 NA 4.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.2 1.9 6.4 2.5 -0.8 0.6 -0.4 -1.1 -1.6
Bipolar Disorder or Schizophrenia 1.9 4.6 10.2 1.0 -1.9 -1.4 -2.3 -2.4 -3.2
Depressed Affect (Nagel 2018) 0.6 1.3 3.3 -0.1 1.8 1.8 0.8 0.2 0.9
Depression (Nagel 2018) 0.1 0.2 1.0 -1.0 0.1 0.3 0.2 0.1 -0.1
Intelligence (Savage-Jansen 2018) 1.3 3.9 9.7 3.1 -2.0 -1.3 0.5 1.6 -2.2
Neuroticism (Nagel 2018) 1.3 2.9 6.9 -0.2 2.6 2.6 0.9 -1.3 1.1
Schizophrenia (2018) 2.3 4.7 7.7 -0.7 -1.9 -2.2 -2.7 -2.2 -2.8
Schizophrenia vs Biploar Disorder 0.8 1.1 1.7 -1.0 -0.8 -1.3 -1.2 -1.3 -0.5
Worry (Nagel 2018) 2.7 5.7 11.8 0.8 3.3 3.4 2.1 -1.0 2.4
Alzheimer’s Disease (in mother) 1.7 2.0 5.0 1.0 1.6 2.2 0.9 -0.2 1.6
Alzheimer’s Disease (in father) 0.5 0.6 1.6 1.0 -0.7 -0.4 -0.5 0.0 -1.2
Alzheimer’s Disease (including proxy) 0.3 0.5 1.0 0.7 0.4 1.0 -0.6 -1.0 0.0
Crohns Disease (2017) 0.8 1.7 6.6 -1.1 0.3 0.2 -1.5 -2.6 0.0
Irritable Bowel Disease (IBD) 0.8 2.0 3.8 -0.1 1.9 1.9 -0.0 -1.9 0.8
Ulcerative Colitis (UC) 2.2 4.1 9.4 1.1 2.7 3.1 1.7 -0.5 1.9
Major Depression (MDD) 0.7 0.9 2.6 0.2 1.6 0.9 -0.6 -1.3 -0.2
Reaction Time 0.6 1.2 2.3 -1.1 1.4 0.8 -0.2 -1.5 1.0
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.8 1.9 -1.5 -0.4 0.1 0.7 -2.0
Breast Cancer 20.9 50.3 82.3 -1.9 -9.1 -8.7 -8.2 -2.5 -8.3
Ovarian Cancer 0.8 1.1 2.4 1.4 -0.6 0.3 0.9 1.6 0.9
Prostate Cancer 2.3 3.2 5.2 -1.8 1.8 -1.4 1.5 2.0 2.3
Age at First Birth 1.3 1.8 3.4 0.4 -1.4 -1.3 -1.2 -1.5 -1.8
Bipolar Disorder (2011) 0.7 0.7 2.1 1.4 -0.9 -0.1 -0.3 -0.1 -1.1
Body Mass Index (BMI) (2010) 3.1 4.2 7.4 -1.7 -1.2 -2.7 -2.3 -2.4 -1.6
Coronary Artery Disease (CAD) 0.2 0.2 0.6 0.2 0.8 -0.2 0.1 -0.1 -0.6
Crohns Disease (2012) 0.6 0.9 4.5 0.3 0.6 0.4 -0.6 -2.1 0.0
Mean Putamen Volume 0.3 0.4 1.0 1.0 -0.1 0.2 -0.4 0.8 -0.6
Fasting Glucose 0.6 0.8 1.9 -1.4 -0.2 -0.0 0.2 1.1 1.2
HbA1C 1.8 2.0 4.8 -1.1 -0.6 -0.5 -2.1 -2.2 -1.0
HDL Cholesterol 1.0 1.7 2.9 1.4 1.6 1.7 1.4 -0.5 0.9
LDL Cholesterol 1.3 2.0 4.0 -1.5 0.3 -1.2 -2.0 -2.0 -0.4
Lupus 1.0 1.6 3.3 1.0 1.5 1.8 1.4 0.6 0.9
Neuroticism (2016) 1.1 1.6 6.4 -0.4 -0.3 0.8 -1.5 -2.5 -0.3
Primary Biliary Cirrhosis 0.4 0.6 1.7 0.1 1.3 0.6 0.1 -1.1 0.5
Rheumatoid Arthritis 1.2 1.6 2.8 -1.7 1.5 1.5 0.8 -0.3 1.3
Schizophrenia (2014) 3.2 7.2 13.1 -0.0 -2.3 -2.3 -3.2 -3.0 -3.6
Triglycerides 0.2 0.3 1.0 -0.4 0.4 0.4 0.4 0.1 1.0
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.2 -0.3 1.2 1.2 0.7 0.4 1.5
Ulcerative Colitis 1.5 2.1 5.0 1.6 1.6 2.2 0.7 -1.5 -0.4
Blood Eosinophil Count 2.0 15.7 25.3 -5.0 -4.0 -4.7 -4.5 -1.2 -3.1
Blood Platelet Count 0.1 0.9 1.4 1.0 -1.2 -1.2 -0.5 0.6 -0.9
Blood Red Count 0.7 6.5 14.5 3.8 0.8 3.5 2.7 1.8 0.8
Blood White Count 0.5 3.8 7.7 0.3 -1.9 -2.8 -2.4 0.4 -2.3
Heel T-Score 0.9 7.2 18.1 3.2 1.9 4.3 2.2 0.5 2.3
BMI 6.3 36.6 69.2 -6.7 -3.8 -8.3 -7.6 -2.7 -5.0
Height 0.2 4.6 18.1 4.3 -0.8 2.1 1.9 -0.8 0.2
Waist Hip Ratio (WHR) 0.1 0.3 1.2 -0.2 0.2 -0.3 -1.1 -0.6 0.1
Systolic Blood Pressure 3.1 15.8 34.4 2.5 3.4 3.6 5.9 5.0 2.2
Smoking Status 2.1 5.0 13.5 0.6 1.9 1.2 3.0 3.7 1.4
Allergy or Eczema 0.5 1.2 3.9 -0.0 1.4 1.1 0.0 -0.6 2.0
Cardiovascular Disease 0.6 1.8 5.4 -2.3 0.4 -2.1 -0.9 0.5 0.1
Hypothyroidism (self reported) 1.3 3.1 5.0 -2.2 -1.9 -1.7 -1.7 -1.3 -1.6
Respiratory disease 0.4 0.9 3.5 0.2 0.7 0.7 0.8 0.6 1.9
Type 2 Diabetes (T2D) (2018) 0.2 0.5 1.3 -1.1 0.3 0.1 -0.4 -0.7 0.9
Lung FEV1/FVC ratio 2.4 12.2 20.7 -1.2 -4.5 -4.2 -3.8 -0.8 -4.3
Lung FVC 0.6 2.9 7.0 2.6 -1.5 -0.0 1.9 2.1 -0.5
Neuroticism 0.8 2.0 5.7 0.3 1.6 2.4 1.3 -0.4 1.3
Chronotype (morning person) 4.0 9.2 18.4 -2.8 -1.4 -3.0 -4.3 -4.0 -1.4
Hair Pigment 0.2 6.1 9.5 0.6 2.8 2.7 2.6 2.2 3.1
Tanning 0.1 1.3 5.2 0.7 -0.6 0.6 -0.9 -2.3 -0.7
Hand grip strength (left) 1.8 4.7 12.0 0.4 -1.7 -3.4 0.0 3.5 -1.2
Number of treatments/medications taken 0.6 1.0 3.0 -1.7 1.2 0.5 0.5 0.4 1.0
Average weekly spirits intake 2.3 2.8 5.9 1.5 1.6 1.6 1.9 2.4 0.4
Sensitivity / hurt feelings 0.3 0.6 1.2 -0.9 -0.7 1.1 -0.1 -0.9 0.1
Frequency of depressed mood in last 2 weeks 0.7 1.0 3.7 -0.4 -0.1 0.5 1.1 1.9 0.7
Hearing difficulty/problems: Yes 0.1 0.2 0.5 0.7 0.1 0.2 0.1 0.3 0.6
Relative age of first facial hair 1.3 2.8 5.2 2.3 0.3 1.9 1.9 1.0 1.6
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 6.7 -2.6 -0.0 -0.9 -1.1 -1.0 -0.5
Ever used hormone-replacement therapy (HRT) 1.2 1.5 4.2 -0.6 1.3 0.1 1.4 2.0 1.0
Ever had hysterectomy (womb removed) 2.7 3.1 7.4 0.4 2.7 2.2 1.5 0.0 2.0
Systolic blood pressure, automated reading 2.0 5.7 13.1 0.7 2.6 1.2 3.0 3.6 1.9
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 3.4 0.2 -0.1 -1.2 -1.2 -1.8 0.1
Angina 0.6 0.8 2.0 0.5 0.7 0.4 1.1 1.4 -0.8
Medication for hormone replacement therapy 3.1 3.5 6.2 0.9 1.1 1.5 2.5 2.3 2.3
Vitamin and mineral supplements 2.8 3.8 19.9 -0.5 -0.4 -1.0 1.2 4.5 0.5
Supplements: Zinc 0.2 0.2 0.4 0.6 0.1 0.4 0.3 -0.6 0.4
Medication: Co-codamol 1.0 1.2 4.0 0.5 -1.4 -0.7 0.1 2.0 -0.7
Medication: Metformin 0.3 0.5 2.2 -1.5 0.4 -0.1 -0.3 -0.5 0.2
Diabetes (father) 0.3 0.4 1.3 0.0 -0.1 -0.5 -1.1 -0.8 0.2
Diabetes (mother) 0.7 0.9 3.6 -1.9 0.2 -1.2 -0.4 0.2 -0.6
Severe depression (siblings) 1.2 1.3 2.9 0.3 -1.2 -1.3 -1.3 0.5 -1.7
Pack years adult smoking proportion 0.7 1.0 4.0 0.3 -0.1 0.4 1.3 2.0 0.4
Impedance of leg (right) 4.6 22.1 52.6 4.2 3.8 7.3 4.9 1.8 4.6
Leg fat-free mass (left) 2.1 11.1 23.6 -2.7 -2.8 -4.9 -3.4 -1.1 -3.9
Trunk fat percentage 0.6 2.2 6.5 -1.3 0.9 -1.4 -2.6 -1.3 -0.4
Hand grip strength (right) 0.9 2.4 8.8 0.7 -1.1 -1.7 0.6 3.0 -0.8
Townsend deprivation index at recruitment 2.5 3.5 6.2 -0.9 -2.5 -2.1 0.2 2.3 -2.2
Current tobacco smoking 2.6 4.2 8.7 1.0 0.9 2.1 2.8 2.9 1.6
Average weekly fortified wine intake 0.2 0.3 0.6 -0.3 0.8 0.6 0.5 0.4 0.4
Maternal smoking around birth 0.4 0.6 1.7 -0.3 0.9 -1.0 0.1 1.3 -0.4
Fed-up feelings 0.5 0.9 2.1 -0.1 -1.3 -0.9 -0.8 0.6 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.6 -0.6 -0.9 0.0 0.4 1.2 -1.0
Relative age voice broke 0.3 0.5 1.1 0.7 -1.0 0.7 0.7 0.3 0.5
Taking other prescription medications 1.3 2.0 3.6 0.3 1.3 1.9 1.6 0.6 1.8
Age when periods started (menarche) 1.0 2.3 4.2 2.1 1.9 1.8 1.3 -0.1 1.0
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 5.2 1.0 2.3 2.0 0.6 -0.2 1.7
Heel bone mineral density (BMD) T-score, automated (left) 2.7 6.2 8.1 2.8 2.2 2.6 2.6 2.1 2.3
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.8 -1.1 -0.5 -1.3 -0.2 1.4 -0.7
Qualifications: CSEs or equivalent 1.3 1.7 3.7 -0.7 1.1 1.9 1.1 0.2 1.9
Serious illness, injury or assault to yourself 1.6 2.0 4.6 2.1 1.8 1.3 1.3 -0.1 0.9
High blood pressure 0.7 2.0 5.6 -1.7 0.4 -2.4 -1.1 1.2 -0.7
Hayfever, allergic rhinitis or eczema 0.6 1.4 3.3 -1.3 1.6 0.8 -0.2 0.2 1.8
Multivitamins +/- minerals 3.2 4.1 19.3 -1.2 0.1 0.5 -1.7 -4.4 -0.9
Stomach or abdominal pain in last month 0.4 0.5 1.0 0.9 -0.9 -0.1 0.1 0.8 -1.0
Supplements: Glucosamine 0.5 0.6 2.0 -1.4 -0.8 -0.5 -0.7 -0.4 0.3
Diverticular disease/diverticulitis (self-reported) 2.0 2.3 5.7 1.7 0.2 1.2 1.9 2.4 0.5
Medication: Atenolol 0.6 0.7 2.1 -0.2 -1.2 0.2 -0.6 -0.4 -1.5
Medication: Levothyroxine sodium 0.8 1.4 5.2 -2.3 -0.6 -1.4 -0.7 0.2 -0.4
Sitting height 0.2 1.3 4.0 2.0 -1.5 0.3 0.7 0.1 -0.8
Chronic bronchitis/emphysema (father) 0.8 0.9 2.0 -1.2 0.4 -0.5 -1.1 -1.4 0.5
High blood pressure (mother) 0.6 0.9 4.0 -2.0 0.6 -0.5 -0.8 -0.1 -0.3
Body mass index (BMI) 4.7 20.1 43.1 -4.5 -2.4 -6.6 -5.6 -1.3 -4.3
Impedance of leg (left) 4.3 20.7 46.5 4.4 3.6 6.8 4.4 1.6 4.8
Leg predicted mass (left) 2.2 11.4 24.1 -2.8 -2.9 -4.9 -3.5 -1.1 -3.9
Trunk fat mass 1.0 4.5 10.7 -1.9 -0.2 -2.9 -3.3 -1.3 -1.6
Waist circumference 3.5 12.7 25.8 -3.8 -1.4 -5.1 -4.8 -1.3 -3.0
Number of incorrect matches in round 1.0 1.6 4.2 -2.0 0.6 -1.1 -1.5 -1.1 0.5
Past tobacco smoking 0.8 1.4 2.9 0.3 -1.7 -1.1 -1.2 -1.2 -1.1
Alcohol usually taken with meals 1.3 2.1 8.1 -0.2 1.7 0.7 -0.4 -2.8 1.0
Nervous feelings 1.6 2.9 7.3 0.5 2.6 2.7 1.3 -0.7 1.2
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.7 7.1 -0.2 2.7 2.2 2.1 1.5 1.9
Hearing difficulty/problems with background noise 0.2 0.3 0.7 -0.4 0.8 -0.4 -0.5 -0.1 0.8
Hair/balding pattern: Pattern 2 0.7 0.9 2.9 -0.4 -1.2 -0.9 0.1 1.7 -0.5
Had menopause 1.3 1.7 6.8 -1.0 0.9 -0.9 0.7 2.6 0.4
Had other major operations 2.3 2.8 12.2 -3.5 1.0 1.3 0.6 -0.3 1.1
Forced vital capacity (FVC) 0.7 2.6 6.3 2.5 -0.6 1.0 2.5 1.3 0.3
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.4 7.0 2.1 2.6 2.2 1.3 -0.0 1.7
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.2 -0.3 -0.5 0.2 0.9 1.5 0.3
Qualifications: None of the above 0.3 0.5 1.7 -0.6 1.3 0.6 0.3 -0.2 0.8
Financial difficulties in last 2 years 0.6 0.8 3.3 0.0 0.2 -0.3 0.6 1.8 0.9
Mouth/teeth dental problems 2.0 3.0 6.2 -1.6 -1.0 -1.3 -2.4 -2.5 -0.8
Heart attack 1.7 2.1 7.0 -0.3 -1.8 -1.1 -1.0 0.0 -2.7
Allergy 0.6 1.5 3.5 1.3 -1.4 -1.1 -0.2 -0.5 -1.9
Pain all over the body in last month 1.3 1.4 3.4 -0.5 0.8 1.8 1.2 -0.6 1.6
Diabetes (self-reported) 0.3 0.5 2.3 -0.7 0.3 -0.1 -0.2 -1.5 -0.3
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.8 -0.9 0.3 -0.3 0.2 0.9 1.4
Medication: Ramipril 0.3 0.4 1.6 0.7 -0.6 -1.3 -0.2 0.0 -0.1
Medication: Simvastatin 0.6 0.8 3.3 -1.0 -0.5 -1.8 -0.1 0.4 -0.3
Fluid intelligence score 1.5 3.0 6.3 2.5 -2.0 -1.1 -0.5 0.5 -2.5
Illnesses of siblings 0.7 1.0 1.8 -0.7 1.2 0.7 0.1 -1.3 1.3
Neuroticism score 0.5 1.1 3.6 0.2 1.0 1.9 1.0 0.3 0.9
Weight 2.5 12.4 28.1 -3.0 -2.4 -5.3 -4.2 -0.9 -3.6
Impedance of arm (right) 6.1 28.4 66.3 5.0 4.4 8.1 5.3 -0.2 5.6
Arm fat percentage (right) 2.3 9.0 20.0 -2.9 -0.7 -3.8 -4.5 -2.1 -2.5
Trunk fat-free mass 2.4 13.6 27.4 -2.8 -3.6 -5.2 -3.4 -0.6 -4.7
Hip circumference 1.0 4.5 9.4 -2.6 0.0 -3.1 -2.7 -0.7 -1.8
Time employed in main current job 1.1 1.2 3.3 -1.3 -0.6 -1.8 -0.9 -0.4 -1.0
Alcohol intake versus 10 years previously 1.1 1.7 4.3 2.1 0.5 1.6 1.6 0.1 0.5
Father’s age at death 0.7 0.9 2.3 1.1 -0.0 0.6 1.5 1.0 0.8
Worrier / anxious feelings 0.7 1.3 3.4 0.1 1.8 1.8 0.8 -0.2 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 3.0 1.1 -0.8 1.0 1.6 1.7 0.1
Falls in the last year 4.3 5.8 9.9 0.5 2.4 2.6 2.9 2.0 3.1
Hair/balding pattern: Pattern 3 0.6 0.9 2.7 1.7 0.1 1.1 0.3 -1.1 0.2
Number of live births 3.8 5.4 11.3 0.7 1.8 2.0 3.4 3.3 1.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 3.7 1.9 -1.2 0.2 1.5 1.2 -0.2
Pulse rate 0.8 1.4 2.3 0.9 -1.5 -1.5 -1.1 -0.3 -1.4
Happiness 1.7 2.0 4.2 -1.1 -2.0 -1.7 -0.9 0.9 -1.5
Noisy workplace 0.3 0.4 1.1 -0.4 -0.3 0.4 0.6 -0.8 1.1
Qualifications: A levels/AS levels or equivalent 0.8 1.9 5.9 -0.3 -2.4 -1.2 -1.2 -0.9 -1.2
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 2.1 0.4 1.3 1.4 1.4 0.6 1.2
Mouth/teeth dental problems: Dentures 0.6 1.1 3.2 -0.6 0.4 0.4 1.4 1.8 0.7
Asthma 0.3 0.5 1.7 0.3 0.4 0.4 0.5 1.3 0.8
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 4.0 1.6 1.5 2.0 1.1 -0.0 0.5
Medication: Cholesterol lowering 0.4 0.7 2.2 -1.0 -0.8 -1.5 -0.4 0.4 -0.3
Depression (self-reported) 0.6 0.7 1.7 0.8 1.2 1.3 0.5 -0.1 -0.2
Medication: Lansoprazole 0.7 0.8 1.7 0.9 0.4 1.3 1.3 0.8 -0.0
Prospective memory result 0.4 0.4 1.3 -1.1 0.1 -0.3 -0.4 0.2 1.0
Lung cancer (father) 0.3 0.4 1.0 0.4 -0.1 -0.4 0.3 1.0 -0.9
Illnesses of mother 0.6 0.8 2.4 1.6 -0.6 1.1 0.7 -0.3 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.4 5.3 2.3 -1.0 -0.2 0.7 1.2 -0.7
Pulse wave Arterial Stiffness index 1.6 1.9 4.0 -0.3 -2.0 -1.5 -1.3 -0.8 -1.7
Impedance of arm (left) 7.4 34.3 82.8 4.9 5.1 9.1 5.5 -0.4 6.5
Arm fat mass (right) 3.0 12.5 24.2 -3.4 -1.4 -4.9 -4.8 -1.7 -3.3
Trunk predicted mass 2.5 14.2 28.3 -2.8 -3.8 -5.3 -3.4 -0.6 -4.8
Standing height 0.3 3.0 6.2 2.5 -0.0 2.3 2.3 0.1 1.1
Length of working week for main job 1.2 1.3 3.5 -0.3 0.1 -1.9 -1.6 -1.2 0.1
Exposure to tobacco smoke at home 2.4 2.7 8.1 -0.2 1.1 0.5 2.2 2.8 1.4
Breastfed as a baby 1.1 1.3 3.2 1.8 -0.8 0.3 1.1 1.5 0.8
Tense / ‘highly strung’ 1.0 1.6 3.2 0.8 1.5 1.7 0.8 -0.3 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 3.6 5.4 10.5 1.4 2.0 3.0 3.2 1.7 2.1
Hair/balding pattern: Pattern 4 0.7 1.6 6.5 -2.5 0.2 -1.6 -0.5 0.3 0.5
Birth weight of first child 0.1 0.2 0.7 -0.9 -0.3 -0.3 -0.1 -0.3 0.3
Peak expiratory flow (PEF) 0.2 0.4 1.0 -0.1 -1.0 -0.7 -0.2 0.6 -0.8
Pulse wave reflection index 1.8 2.2 3.6 -0.6 -1.6 -0.9 -1.9 -1.7 -1.8
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.6 -0.9 0.6 1.6 1.5 0.6 1.2
Loud music exposure frequency 0.5 0.6 1.6 0.1 -0.1 0.9 0.9 -0.1 1.2
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 3.7 0.2 -0.0 1.5 1.9 1.2 1.8
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.9 0.3 0.3 -0.1 0.4 0.9 0.2
Blood clot in the leg (DVT) 0.3 0.4 0.8 -0.7 0.2 0.8 0.2 -0.9 0.3
Medication: Paracetamol 0.5 0.9 3.3 -1.3 0.1 1.8 0.5 -0.5 0.1
Headache pain in last month 1.2 2.1 7.5 1.6 1.1 2.7 1.1 -0.2 0.1
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.8 0.7 0.3 1.3 1.0 0.9 0.1
Glaucoma (self-reported) 3.0 3.6 4.9 1.6 1.5 2.0 2.2 2.1 1.8
Gout (self-reported) 0.5 0.7 1.5 -1.2 0.8 -0.1 -0.4 -1.2 0.9
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 5.2 -2.3 -1.3 -1.4 -1.1 -0.2 -0.7
Medication: Amlodipine 3.1 4.3 8.7 -1.8 -0.7 -3.0 -2.9 -0.6 -2.2
Medication: Ventolin 100micrograms inhaler 0.3 0.3 1.2 1.1 -0.9 0.0 -0.1 -0.0 0.1
Birth weight 1.3 2.8 7.8 -0.9 -1.8 -1.9 -1.0 -0.4 -2.8
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.3 0.5 -1.1 -0.2 -0.8 -0.2 -0.5
High blood pressure (siblings) 0.5 0.7 1.3 -0.0 -0.9 -1.1 -0.9 0.3 -1.0
Forced vital capacity (FVC), Best measure 0.7 2.7 6.9 2.6 0.0 1.0 2.2 1.8 0.3
Body fat percentage 1.0 4.0 10.9 -2.0 0.2 -2.5 -3.3 -1.1 -1.3
Leg fat percentage (right) 1.8 6.5 13.8 -2.4 -0.6 -3.7 -3.7 -0.2 -2.3
Arm fat-free mass (right) 3.0 15.4 33.2 -3.2 -3.4 -5.8 -4.0 -0.4 -4.6
Exposure to tobacco smoke outside home 1.6 2.1 7.1 -0.2 0.8 0.6 1.5 2.7 1.4
Comparative body size at age 10 4.5 12.5 30.4 -4.2 -1.2 -5.5 -3.8 -1.3 -3.2
Number of full brothers 2.0 2.6 6.1 0.6 1.6 1.9 2.5 1.5 0.7
Worry too long after embarrassment 0.6 0.9 2.7 -1.6 1.0 1.0 -0.2 -0.9 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.4 4.4 1.3 1.8 2.1 1.5 0.5 1.7
Wheeze or whistling in the chest in last year 1.1 2.0 3.7 -1.9 1.7 1.0 1.1 1.1 1.3
Number of children fathered 0.5 0.5 1.3 1.2 1.1 -0.4 -0.4 -0.1 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.9 -0.1 -0.1 -0.9 -0.1 -0.0 -0.2
Age at first live birth 2.7 4.9 9.3 -1.9 -1.7 -2.5 -3.1 -1.2 -2.4
Pulse wave peak to peak time 1.9 2.3 4.2 0.6 2.1 1.7 1.5 0.9 1.8
Health satisfaction 0.6 0.8 2.7 0.3 1.6 0.7 0.1 -0.8 1.1
Shortness of breath walking on level ground 3.3 3.9 8.8 -0.1 1.8 2.0 2.1 1.7 3.0
Qualifications: College or University degree 1.1 3.5 5.2 0.7 -2.3 -2.0 -2.0 -1.7 -2.1
Eye problems/disorders: None of the above 0.5 0.6 1.6 -0.9 -0.6 0.1 -0.5 -1.3 0.8
Mouth/teeth dental problems: Loose teeth 3.0 3.6 8.4 0.5 0.9 1.6 2.4 2.9 1.8
Emphysema/chronic bronchitis 1.0 1.1 2.4 -0.6 1.5 1.5 0.9 -0.3 0.9
Medication for pain relief, constipation, heartburn 2.0 3.4 10.0 -1.4 -1.5 -3.2 -2.2 -0.2 -0.9
Neck or shoulder pain in last month 1.5 2.1 3.8 1.9 1.3 1.9 1.5 0.5 1.1
Medication: Blood pressure 0.3 0.5 1.4 -0.7 0.2 -1.2 -0.9 -0.3 -0.2
Angina (self-reported) 0.6 0.8 2.1 0.6 0.8 0.4 1.1 1.4 -0.7
Migraine (self-reported) 1.8 2.3 10.9 3.3 -0.8 1.2 0.3 -0.6 -0.5
Medication: Ibuprofen 1.8 2.2 6.0 1.0 1.8 2.5 1.3 -0.2 0.9
Medication: Allopurinol 0.6 0.9 3.8 -0.6 -0.0 -0.2 -0.9 -1.9 0.1
Medication: Omeprazole 1.6 1.9 4.2 2.0 0.8 1.7 1.4 1.0 0.9
Medication: Seretide 50 evohaler 0.5 0.5 1.3 -1.1 -0.2 0.8 0.2 0.0 1.1
Mean time to correctly identify matches 1.0 2.0 4.5 -2.1 1.8 0.6 0.1 -1.4 1.3
Heart disease (mother) 1.0 1.2 3.8 -0.4 0.7 -1.6 0.1 2.0 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 4.2 0.7 1.2 2.1 1.4 -0.9 1.7
Whole body fat mass 1.9 7.8 16.1 -2.7 -0.9 -4.0 -4.0 -1.1 -2.4
Leg fat mass (right) 2.7 10.6 23.6 -3.1 -1.5 -4.9 -4.3 -0.5 -3.1
Arm predicted mass (right) 2.8 14.4 31.2 -2.9 -3.3 -5.6 -3.9 -0.4 -4.5
Pulse rate, automated reading 0.2 0.5 1.1 -0.3 -0.7 -0.8 -0.9 0.5 -1.0
Alcohol intake frequency. 0.1 0.3 0.5 0.5 -0.6 0.7 -0.4 -0.6 -0.5
Comparative height size at age 10 0.5 2.6 7.1 1.0 1.5 2.7 1.6 0.1 1.7
Number of full sisters 0.9 1.2 4.2 -0.6 0.5 0.4 1.3 2.1 0.6
Suffer from ‘nerves’ 3.3 5.2 9.1 1.4 2.3 2.7 3.0 1.6 2.2
Overall health rating 0.1 0.2 0.7 -0.1 0.4 0.5 0.2 0.4 -0.8
Chest pain or discomfort 0.3 0.5 1.6 0.3 -0.2 0.4 0.8 1.3 -0.6
Had major operations 1.6 1.8 8.8 3.0 0.1 1.3 0.4 -0.2 -0.5
Age at last live birth 0.6 0.9 1.5 -0.9 -0.6 -1.1 -1.1 0.2 -1.2
Family relationship satisfaction 1.8 2.2 4.1 -0.7 -1.7 -2.0 -1.3 -0.6 -1.9
Leg pain on walking 0.9 1.2 3.5 -0.6 1.9 0.7 1.0 0.7 1.2
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.6 -0.3 1.3 -0.1 -1.0 -1.1 -0.6
Commuting to job workplace: Car/motor vehicle 1.5 1.8 4.8 0.4 1.2 2.2 1.3 -0.4 1.5
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 0.7 -0.5 -0.6 -0.0 0.4 -0.0
Medication: Aspirin 0.5 0.7 1.3 0.8 0.5 0.9 1.1 1.0 0.3
Supplements: Vitamin C 1.1 1.3 4.2 1.4 0.4 1.3 -0.0 -2.0 -0.1
Knee pain experienced in last month 0.2 0.3 1.6 -0.1 -1.3 -0.3 -0.4 -0.3 -0.3
Hypertension (Self-reported) 0.8 2.1 6.1 -1.8 0.3 -2.5 -1.1 1.1 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 2.9 4.4 1.1 1.6 1.9 2.1 1.2 2.0
Illnesses of father: Heart disease 1.3 1.8 3.9 -0.4 -1.1 -1.1 -1.7 -1.4 -2.0
Illnesses of siblings: Diabetes 0.4 0.4 1.1 -0.5 -1.1 -0.2 -0.5 0.9 -0.2
Smoking status: Previous 0.3 0.5 1.5 -0.1 1.2 0.3 0.6 0.8 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.3 -0.4 -0.5 -0.2 0.0 0.6 0.3
Whole body fat-free mass 2.6 14.8 30.5 -3.0 -3.5 -5.5 -3.8 -0.9 -4.7
Leg fat-free mass (right) 2.2 11.8 26.3 -2.6 -3.0 -5.1 -3.5 -1.0 -3.8
Arm fat percentage (left) 2.0 7.9 18.3 -2.9 -0.6 -3.5 -4.3 -2.0 -2.1
Average weekly red wine intake 1.2 1.8 5.2 -2.0 -0.7 -2.3 -1.0 -0.2 -0.1
Handedness (chirality/laterality): Left-handed 5.2 6.3 14.1 0.8 -3.1 -3.8 -2.4 0.3 -2.7
Mood swings 0.3 0.6 1.4 -0.2 1.2 1.0 -0.0 -0.1 1.0
Loneliness, isolation 0.3 0.4 0.8 -0.1 -0.3 0.8 0.9 0.9 -0.3
Long-standing illness, disability or infirmity 0.6 1.0 2.6 -1.6 -1.2 -0.5 -0.6 -0.7 -0.7
Ever had bowel cancer screening 0.3 0.4 1.2 -0.7 0.3 1.1 0.1 -0.2 0.8
Diabetes diagnosed by doctor 0.3 0.5 1.5 -0.7 0.7 0.5 0.0 -1.2 0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.2 3.3 -0.7 -1.8 -0.8 -0.9 -0.0 -1.5
Friendships satisfaction 3.8 4.7 6.9 -1.9 -2.6 -2.2 -2.6 -1.3 -2.2
Qualifications: nursing, teaching 0.3 0.4 1.2 -0.7 -1.1 -0.5 -0.3 0.4 -0.3
Commuting to job workplace: Walk 0.3 0.3 0.8 0.2 0.7 -0.2 0.8 0.9 0.3
Eye problems/disorders: Cataract 0.6 0.7 1.3 1.1 1.1 0.9 0.5 0.8 -0.3
Mouth/teeth dental problems: Mouth ulcers 3.8 6.0 10.9 3.3 2.5 2.9 2.7 0.7 1.7
Medication for cholesterol 0.7 1.1 4.4 0.2 -1.1 0.5 -0.7 -2.1 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.8 0.4 1.0 1.7 1.5 1.0 0.8
Back pain experienced in last month 0.9 1.4 4.6 2.1 -0.7 1.0 1.3 0.4 -0.5
Mineral and other dietary supplements 0.6 0.8 3.0 0.3 -0.7 -0.6 0.4 1.7 -0.7
Breast cancer (self-reported) 7.7 9.1 17.9 -0.3 4.2 3.6 2.6 -0.7 4.1
Asthma (self-reported) 0.2 0.5 2.1 0.3 0.2 0.1 0.4 1.5 0.6
Osteoporosis (self-reported) 0.8 1.0 2.2 0.0 -0.7 -1.2 -1.5 -0.6 -1.2
Osteoarthritis (self-reported) 0.7 0.9 1.9 1.3 0.8 0.9 0.5 0.6 1.4
Medication: Aspirin 0.4 0.6 1.3 0.7 0.4 0.6 1.1 1.1 0.0
Medication: Gliclazide 0.7 0.8 2.0 -1.4 -0.4 -0.5 -1.1 -1.0 -0.1
Illnesses of father: None of the above (group 1) 0.5 0.7 3.1 0.2 0.3 -0.0 0.6 1.8 0.5
Smoking status: Current 1.8 2.8 6.5 0.7 0.6 1.7 2.4 2.5 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.5 1.0 -0.2 -1.3 0.5 1.6 -0.2
Whole body water mass 2.7 15.2 31.2 -3.0 -3.6 -5.6 -3.8 -0.9 -4.8
Leg predicted mass (right) 2.2 11.6 25.5 -2.7 -3.0 -5.1 -3.5 -1.1 -3.8
Arm fat mass (left) 3.2 13.3 25.0 -3.6 -1.6 -5.0 -5.0 -1.9 -3.3
Number of self-reported non-cancer illnesses 0.2 0.4 1.3 -1.1 -0.2 0.4 0.1 0.6 0.6
Average weekly champagne plus white wine intake 1.3 1.7 8.5 0.2 0.4 0.5 -1.2 -2.9 0.4
Miserableness 0.9 1.5 3.4 1.0 0.4 1.9 1.4 1.3 0.9
Guilty feelings 1.4 2.1 4.1 1.8 1.6 2.0 1.5 -0.6 0.5
Wears glasses or contact lenses 0.6 0.7 1.2 1.0 0.8 0.2 -0.4 -1.1 -1.0
Ever taken oral contraceptive pill 1.8 2.0 3.0 1.3 1.7 1.1 1.5 1.6 1.1
Hearing aid user 0.2 0.3 0.5 0.5 0.7 -0.2 -0.2 -0.6 0.7
Mother’s age at death 0.3 0.4 0.8 -0.9 0.7 -0.7 0.4 0.6 0.1
Financial situation satisfaction 1.2 1.4 2.8 -0.4 -1.7 -1.7 -1.6 0.0 -0.5
Tinnitus: Yes, now most or all of the time 2.9 3.4 5.9 2.4 1.4 2.2 2.4 0.9 1.2
Commuting to job workplace: Public transport 0.4 0.5 1.5 -0.0 -0.6 -1.0 0.0 1.2 -0.5
Eye problems/disorders: Glaucoma 3.1 3.7 6.3 1.7 1.8 2.0 2.5 2.1 1.2
Medication: Blood pressure 1.5 2.9 7.5 -1.7 -0.1 -2.7 -1.7 0.5 -1.9
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 0.3 -0.4 -0.1 -0.3 0.4 0.5
Supplements: Fish oil (including cod liver oil) 1.0 1.4 5.7 -0.3 -0.2 0.1 -1.5 -2.4 -0.3
High cholesterol (Self-reported) 0.5 0.8 3.2 -1.8 -0.3 -1.3 -0.2 -0.0 0.4
Medication: Bendroflumethiazide 0.3 0.4 1.4 0.1 0.1 -1.2 -0.6 -0.5 -0.5
Medication: Paracetamol 0.9 1.4 4.0 -1.6 0.7 2.0 0.8 -0.5 0.7
Medication: Lisinopril 0.3 0.4 1.3 -0.6 0.3 -0.4 -0.2 1.2 -0.5
Medication: Atorvastatin 0.5 0.7 2.5 -0.5 1.6 0.3 0.7 0.3 0.8
Illnesses of father: High blood pressure 0.5 0.6 1.5 0.6 -0.4 -0.9 0.5 1.2 -0.9
Alcohol drinker status: Never 1.9 2.3 6.1 -1.0 -1.2 -2.5 -0.5 1.9 -1.1
Ever smoked 0.9 1.6 2.2 0.3 1.4 1.5 1.3 1.2 1.4
Basal metabolic rate 2.6 14.2 29.8 -3.0 -3.2 -5.5 -3.9 -1.0 -4.5
Leg fat percentage (left) 2.0 7.1 16.1 -2.4 -0.6 -4.0 -4.0 -0.3 -2.2
Arm fat-free mass (left) 3.4 17.3 37.3 -2.9 -3.7 -6.1 -4.3 -0.6 -5.0
Number of operations (self-reported) 1.2 1.7 4.8 -0.6 1.9 2.2 0.5 -0.7 1.0
Average weekly beer plus cider intake 0.8 1.1 2.6 -0.4 0.7 1.3 1.4 1.6 0.0
Irritability 0.4 0.7 1.4 -0.6 -0.7 -0.6 -1.2 -0.5 -1.0
Risk taking 1.2 1.7 2.9 -1.7 -0.1 -0.3 -1.6 -1.6 1.5
Ever had prostate specific antigen (PSA) test 3.8 4.3 8.9 -1.5 -1.4 -2.0 -3.0 -2.8 -1.0
Fractured/broken bones in last 5 years 0.3 0.4 0.7 0.5 0.8 0.6 0.3 -0.8 0.2
Age started oral contraceptive pill 0.4 0.5 1.3 -1.1 0.0 -1.1 -0.5 -0.5 -0.0
Diastolic blood pressure, automated reading 4.8 15.0 27.8 -1.5 -4.8 -5.3 -3.7 0.5 -4.9
Ever depressed for a whole week 2.5 3.1 7.1 -0.1 1.2 1.4 2.7 2.2 1.9
Unable to work because of sickness or disability 0.3 0.4 1.0 0.1 0.2 0.8 0.9 1.0 -0.2
Commuting to job workplace: Cycle 1.9 2.2 6.2 -1.4 -0.5 -2.5 -1.7 -1.4 -0.4
Myopia 0.6 0.9 2.9 -0.0 -0.6 -1.4 0.3 1.7 -0.5
Vascular/heart problems diagnosed by doctor 0.6 1.5 4.4 1.1 -0.1 2.1 0.9 -1.1 1.2
Cholesterol lowering medication 0.2 0.3 1.2 -0.7 1.1 -0.1 0.3 -0.0 0.3
Medication: Omeprazole (e.g. Zanprol) 1.7 2.1 3.4 1.9 0.9 1.8 1.7 0.6 1.4
Pain experienced in last month 0.7 1.1 3.5 -1.9 0.5 -1.2 -0.9 -0.6 0.5
Supplements: Calcium 0.7 0.8 3.4 0.9 -0.2 0.1 -0.6 -1.8 -0.2
Basal cell carcinoma (self-reported) 0.6 0.7 2.1 -0.3 0.7 -0.4 0.5 1.0 -1.4
Heart attack/myocardial infarction (self-reported) 1.5 1.9 6.1 -0.3 -1.8 -1.1 -0.9 0.3 -2.5
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.8 -0.9 0.3 0.8 0.5 -0.5 0.5
Heart disease (siblings) 1.5 1.8 5.2 2.3 -0.6 0.0 0.8 2.0 -0.8
Alcohol drinker status: Previous 0.6 0.7 3.1 0.1 -0.2 1.8 1.1 0.1 0.1
Pack years of smoking 0.4 0.6 2.0 0.1 -0.1 0.6 1.0 1.4 0.3
Impedance of whole body 6.4 32.8 77.2 5.1 4.8 8.8 5.5 0.5 6.4
Leg fat mass (left) 2.8 10.8 24.9 -3.0 -1.5 -5.0 -4.4 -0.5 -3.0
Arm predicted mass (left) 3.3 16.8 36.5 -2.9 -3.5 -6.0 -4.2 -0.7 -5.0