Hub : Genes

ADSL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1180	0.0420	6.3e-06	0.038	0.048	0.038	0.052	0.042	2.0e-05	1.6e-06	0.00002	5.7e-07	6.1e-06
2	GTEx	Adipose Visceral Omentum	0.1520	0.0640	2.8e-03	0.015	NA	0.022	NA	0.005	5.4e-02	NA	0.02400	NA	1.6e-01
3	GTEx	Testis	0.1790	0.0800	9.9e-03	0.129	NA	0.063	NA	0.095	2.5e-06	NA	0.00091	NA	5.2e-05
4	TCGA	Breast Invasive Carcinoma	0.0500	0.0256	3.2e-05	0.006	0.009	0.015	NA	0.008	2.1e-02	4.4e-03	0.00042	NA	6.9e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0438	0.0253	1.4e-03	0.030	0.027	0.032	NA	0.022	2.2e-04	4.8e-04	0.00016	NA	1.3e-03
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0710	0.0380	2.1e-04	0.021	0.053	0.025	NA	0.023	2.2e-02	5.2e-04	0.01300	NA	1.7e-02
7	TCGA	Liver Hepatocellular Carcinoma	0.0580	0.0350	3.6e-03	0.006	0.032	0.005	NA	0.005	1.7e-01	1.1e-02	0.18000	NA	1.8e-01
8	TCGA	Lung Adenocarcinoma	0.0341	0.0218	4.0e-03	0.004	0.013	0.005	NA	0.005	1.0e-01	8.9e-03	0.08100	NA	8.1e-02
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0650	0.0400	8.8e-03	0.016	0.024	0.023	NA	0.026	2.6e-02	8.9e-03	0.01000	NA	6.7e-03
10	TCGA	Pancreatic Adenocarcinoma	0.0880	0.0540	8.1e-03	0.029	0.008	0.008	NA	0.015	2.2e-02	1.5e-01	0.14000	NA	7.7e-02
11	TCGA	Prostate Adenocarcinoma	0.0801	0.0459	1.0e-03	0.016	0.016	0.021	NA	0.000	6.9e-03	8.3e-03	0.00230	NA	3.1e-01
12	TCGA	Soft Tissue Sarcoma	0.1430	0.0760	5.8e-06	0.045	0.055	0.054	NA	0.062	1.1e-03	3.3e-04	0.00039	NA	1.5e-04
13	TCGA	Stomach Adenocarcinoma	0.0450	0.0260	7.2e-04	-0.002	0.031	0.006	NA	0.007	4.4e-01	2.6e-03	0.11000	NA	9.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	1.2	2.0	21.9	-0.1	4.7	-1.1	0.8	-0.1	-0.3	-0.4	-0.4	0.6	-0.3	-0.7	-0.5	0.0
Bipolar Disorder or Schizophrenia	1.5	3.6	17.8	-0.5	4.2	-0.6	-0.5	-1.4	-1.9	-1.8	-2.1	-0.3	-1.7	-1.8	-2.5	-1.7
Depressed Affect (Nagel 2018)	0.6	1.2	3.3	-0.6	1.6	0.3	-0.5	1.4	1.2	-0.1	1.4	1.7	1.8	0.3	0.5	0.9
Depression (Nagel 2018)	0.5	0.7	2.9	-0.4	1.7	1.3	-0.5	1.0	0.1	-0.5	0.8	0.3	0.4	1.3	0.6	0.3
Intelligence (Savage-Jansen 2018)	0.9	2.8	7.8	2.5	0.6	0.3	1.7	-0.4	-0.8	1.1	-0.6	-2.8	-2.5	2.5	2.0	0.5
Neuroticism (Nagel 2018)	1.1	2.5	6.3	-2.4	2.5	-0.3	-1.0	1.5	1.7	0.1	1.7	2.2	2.5	-0.3	0.3	1.0
Schizophrenia (2018)	1.6	3.3	7.8	-0.5	1.8	0.2	-1.3	-1.7	-2.2	-2.0	-2.4	-0.9	-1.9	-1.8	-2.8	-2.2
Schizophrenia vs Biploar Disorder	0.5	0.6	1.6	-0.0	-0.4	0.7	-1.3	-0.6	-0.7	-0.9	-0.6	-0.5	-0.3	-0.7	-1.2	-1.1
Worry (Nagel 2018)	2.5	5.3	12.3	-3.5	3.2	-1.1	-0.6	2.0	2.9	1.5	2.6	2.6	3.3	0.1	1.5	2.1
Alzheimer’s Disease (in mother)	1.6	1.8	5.5	-0.9	1.2	0.4	-0.6	1.9	1.3	-0.6	1.9	2.4	2.2	0.4	0.4	1.1
Alzheimer’s Disease (in father)	0.3	0.4	3.7	0.4	1.9	0.6	-0.7	0.1	0.0	-0.2	-0.1	0.3	-0.0	0.2	-0.1	-0.1
Alzheimer’s Disease (including proxy)	1.2	1.7	5.4	-0.8	2.3	1.2	-1.2	1.5	0.5	-1.3	1.0	2.3	1.5	0.4	-0.3	0.1
Crohns Disease (2017)	1.1	2.5	10.6	-1.3	3.3	-0.3	-1.3	-0.8	-0.6	-1.4	-1.1	0.8	0.4	-2.4	-2.4	-1.5
Irritable Bowel Disease (IBD)	1.0	2.4	13.6	-1.4	3.7	0.4	-0.8	1.0	0.9	-0.9	1.0	2.3	1.9	-0.9	-0.9	0.4
Ulcerative Colitis (UC)	2.3	4.3	10.0	-1.0	2.5	1.0	0.4	2.7	2.2	0.0	2.9	3.2	3.1	1.0	1.1	2.3
Major Depression (MDD)	1.2	1.4	4.0	0.4	1.6	2.0	0.0	1.7	-0.0	-1.5	1.0	1.7	1.4	0.8	-0.3	0.0
Reaction Time	0.4	0.7	2.8	-1.7	-1.3	-1.3	-0.8	-0.2	0.6	0.2	0.0	0.4	0.9	-1.0	-0.1	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.5	1.9	1.2	-0.2	1.3	-0.4	-0.8	-0.1	-0.6	-1.4	-1.4	0.7	0.4	0.1
Breast Cancer	17.2	41.3	87.0	3.5	1.8	0.0	-2.9	-6.6	-9.3	-7.1	-8.6	-5.7	-8.7	-4.4	-8.2	-8.1
Ovarian Cancer	0.4	0.5	1.5	-0.2	0.8	-0.4	1.0	0.2	1.0	1.2	0.4	0.6	0.4	0.0	0.6	0.8
Prostate Cancer	1.0	1.5	7.5	-2.7	-1.9	-2.4	0.0	0.0	0.0	0.0	0.0	-1.3	0.0	0.0	0.0	0.0
Age at First Birth	1.6	2.3	5.8	-0.5	1.3	-0.8	-0.9	-1.3	-2.4	-2.0	-1.6	-2.2	-1.9	-0.4	-1.2	-1.6
Bipolar Disorder (2011)	0.5	0.5	4.7	0.1	2.2	-0.6	0.7	-0.2	-0.5	-0.5	-0.4	-0.0	-0.5	-0.2	-0.5	-0.1
Body Mass Index (BMI) (2010)	3.5	4.8	9.9	-0.4	-0.5	-1.2	-3.1	-3.2	-1.9	-0.5	-2.8	-3.1	-2.6	-1.7	-1.6	-2.7
Coronary Artery Disease (CAD)	0.5	0.6	2.7	0.4	-1.6	1.0	0.8	0.7	-0.2	-0.4	0.5	0.7	0.1	1.1	0.5	0.3
Crohns Disease (2012)	1.0	1.7	9.8	-2.1	3.1	-0.6	-0.9	-0.4	0.3	-0.4	-0.3	0.9	0.8	-1.6	-1.2	-0.6
Mean Putamen Volume	0.3	0.4	2.9	0.1	1.7	-0.2	0.1	0.0	-0.3	-0.6	-0.2	0.4	0.0	-0.7	-0.9	-0.2
Fasting Glucose	0.4	0.4	1.2	0.6	-1.0	1.1	-0.7	0.4	0.7	0.7	0.5	-0.1	0.4	0.8	0.7	0.1
HbA1C	1.5	1.7	5.4	0.3	0.1	1.1	-2.1	-0.7	-0.8	-1.5	-1.3	0.3	-0.3	-1.4	-2.3	-1.9
HDL Cholesterol	1.1	1.8	3.5	-0.7	0.0	-0.3	1.4	1.7	1.6	0.9	1.6	1.9	1.6	1.0	1.6	1.6
LDL Cholesterol	1.5	2.4	7.8	-0.4	-1.7	0.3	-2.8	-0.7	-1.6	-2.5	-1.0	-0.0	-0.6	-1.3	-2.0	-2.1
Lupus	1.1	1.6	3.0	1.4	-0.0	0.9	0.5	1.2	1.7	1.4	1.6	1.0	1.2	1.2	1.5	1.6
Neuroticism (2016)	0.9	1.3	3.3	-0.5	1.4	0.0	-1.5	0.1	-0.4	-1.8	-0.4	1.2	0.9	-1.3	-1.8	-1.2
Primary Biliary Cirrhosis	0.3	0.4	1.4	0.5	0.2	0.9	0.1	0.6	0.4	-0.3	0.4	1.2	1.1	-0.4	-0.4	0.2
Rheumatoid Arthritis	1.1	1.6	6.5	-0.7	-2.5	-0.1	0.0	1.1	1.0	-0.4	1.3	2.1	2.0	-0.7	-0.3	0.8
Schizophrenia (2014)	2.1	4.6	9.9	-0.0	2.7	0.1	-1.5	-1.8	-2.7	-2.7	-2.6	-0.8	-2.2	-2.0	-3.1	-2.6
Triglycerides	0.3	0.4	0.9	-0.2	-0.5	0.9	0.2	0.7	0.5	0.2	0.9	0.3	0.9	0.9	0.8	0.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.7	-1.6	-0.4	-1.2	-0.2	-0.3	1.4	1.4	0.3	0.8	0.9	-1.4	-0.1	0.7
Ulcerative Colitis	1.6	2.2	5.9	-0.7	2.4	0.6	2.0	1.9	1.2	-0.1	1.6	2.3	1.7	0.8	0.7	1.3
Blood Eosinophil Count	1.5	11.5	24.3	-2.8	2.4	-0.7	-4.9	-2.7	-4.5	-4.7	-3.2	-2.6	-3.0	-1.9	-3.5	-4.5
Blood Platelet Count	0.1	1.5	4.4	1.8	1.1	0.7	-0.7	0.6	-1.9	-2.1	-0.0	-0.5	-1.2	1.8	0.3	-0.6
Blood Red Count	1.9	18.7	41.5	3.9	3.2	5.5	3.4	6.4	2.4	-0.9	5.2	5.4	4.0	5.6	3.2	4.0
Blood White Count	0.5	4.0	8.1	2.4	-0.9	1.3	-1.4	-1.9	-2.6	-1.4	-2.5	-2.6	-2.9	-0.2	-1.6	-2.4
Heel T-Score	2.3	18.1	37.3	1.9	5.4	5.0	1.9	6.1	3.2	-0.1	5.2	5.0	4.5	5.2	3.5	3.5
BMI	6.7	38.8	73.0	0.6	-4.4	-1.9	-5.4	-7.8	-7.4	-3.8	-8.5	-7.7	-8.0	-4.5	-6.0	-8.3
Height	0.4	7.3	41.2	1.6	6.4	0.9	2.4	3.0	1.5	0.0	2.6	2.7	2.4	2.1	2.0	2.2
Waist Hip Ratio (WHR)	0.3	1.4	7.6	1.9	-1.6	2.8	-0.4	1.1	0.1	-0.8	0.2	1.0	0.7	0.8	-0.5	-0.6
Systolic Blood Pressure	2.4	12.0	30.6	-0.8	-1.9	-0.5	4.3	1.9	4.4	5.5	3.7	0.7	2.0	2.7	4.9	5.5
Smoking Status	2.2	5.4	13.5	0.5	-2.3	1.2	3.3	1.9	1.5	2.3	2.4	-0.4	0.6	3.7	3.7	2.8
Allergy or Eczema	1.4	3.6	10.6	-3.3	2.6	-2.9	-2.2	-0.3	0.7	-0.5	0.4	1.7	1.8	-2.7	-0.9	-0.1
Cardiovascular Disease	1.2	3.9	10.0	-2.0	-3.1	-1.7	-2.4	-2.4	-1.3	0.3	-1.8	-3.2	-2.3	-0.4	-0.0	-1.5
Hypothyroidism (self reported)	1.0	2.3	6.1	2.0	-1.6	2.5	-0.3	0.3	-2.0	-2.4	-0.9	-0.5	-0.9	1.3	-1.0	-1.6
Respiratory disease	0.2	0.5	2.1	-0.2	0.6	-0.3	-0.7	0.2	1.1	0.7	0.8	0.7	1.4	-0.7	0.2	0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.2	-0.4	-1.5	0.4	-0.9	-0.2	0.5	0.0	-0.3	0.8	0.8	-1.3	-1.1	-0.5
Lung FEV1/FVC ratio	2.6	13.1	26.5	0.1	-0.7	-2.7	-2.4	-4.8	-4.2	-2.2	-5.2	-3.7	-5.0	-3.8	-4.0	-4.1
Lung FVC	0.5	2.5	7.4	2.0	0.3	-1.1	1.7	0.0	0.3	1.8	0.6	-2.0	-1.4	2.2	2.7	1.7
Neuroticism	1.0	2.3	5.4	-1.9	2.3	-0.5	-0.2	1.6	1.7	0.4	1.8	1.9	2.3	0.2	0.9	1.3
Chronotype (morning person)	5.8	13.4	28.1	-1.0	-1.3	-2.1	-3.8	-5.2	-2.5	-0.9	-5.1	-3.0	-3.2	-5.3	-4.8	-4.8
Hair Pigment	0.3	9.5	22.0	1.9	-2.3	2.8	2.3	4.7	1.9	-0.4	4.1	3.8	3.7	3.7	2.7	3.0
Tanning	0.1	1.4	6.6	1.4	-0.1	2.6	1.0	1.5	-0.4	-1.5	0.5	1.3	0.4	1.5	-0.3	-0.3
Hand grip strength (left)	2.3	6.0	27.9	2.3	-1.0	-0.7	0.8	-2.8	-2.0	1.6	-2.3	-5.3	-4.3	1.4	1.3	-0.9
Number of treatments/medications taken	0.2	0.4	2.0	-0.2	0.3	1.4	0.3	0.3	0.9	0.9	0.4	0.4	1.0	0.2	0.1	0.4
Average weekly spirits intake	1.7	2.1	4.4	0.9	-1.3	0.4	1.3	2.1	0.9	0.3	2.1	0.8	1.2	2.1	2.0	1.8
Sensitivity / hurt feelings	0.9	1.5	4.5	-0.3	-0.3	2.1	-0.3	1.9	0.3	-1.4	1.1	2.0	1.7	0.7	-0.4	0.2
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.4	-0.8	1.9	1.1	-0.2	1.4	0.6	0.3	1.5	0.1	0.6	2.1	1.7	1.0
Hearing difficulty/problems: Yes	0.9	1.3	3.9	1.3	0.1	2.0	-0.2	1.7	0.0	-1.1	1.4	1.1	1.1	1.5	0.5	0.4
Relative age of first facial hair	2.9	6.0	14.4	0.8	1.6	2.6	1.7	3.5	1.9	0.5	3.1	2.4	2.4	3.8	2.9	2.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.3	-0.6	-0.9	0.8	-1.4	-0.7	-0.9	-1.1	-0.8	-0.2	-0.4	-0.9	-1.5	-1.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.8	0.5	-1.7	-0.1	0.9	0.0	0.7	1.7	0.5	-0.9	-0.2	1.1	1.6	0.9
Ever had hysterectomy (womb removed)	1.6	1.8	4.7	-1.7	-0.6	-0.8	0.5	1.1	2.0	1.2	1.6	1.6	2.2	-0.0	1.1	1.4
Systolic blood pressure, automated reading	1.2	3.4	12.5	-0.4	-2.4	-0.5	1.9	0.3	2.4	3.5	1.5	-0.3	0.8	1.1	2.5	2.5
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	9.8	-1.3	0.7	-1.5	-3.1	-1.8	-0.4	-0.1	-1.2	-1.3	-0.7	-1.7	-1.0	-1.6
Angina	2.1	2.7	10.1	2.6	0.2	2.0	1.8	1.1	0.5	1.2	1.0	-0.8	-0.2	3.2	2.4	1.1
Medication for hormone replacement therapy	1.8	2.0	4.5	0.1	-0.8	-0.2	1.7	1.2	1.8	2.0	1.7	0.7	1.3	0.9	1.9	2.1
Vitamin and mineral supplements	1.3	1.7	5.9	0.7	-2.4	-0.5	0.8	-0.3	-0.2	1.3	0.1	-1.9	-1.5	1.7	1.9	0.8
Supplements: Zinc	0.3	0.3	1.3	-1.0	-0.0	-1.1	-0.3	-0.2	0.5	0.3	0.1	0.5	0.5	-1.0	-0.2	0.3
Medication: Co-codamol	0.4	0.5	2.2	0.3	1.5	-0.2	0.2	-0.5	-0.2	0.7	-0.3	-0.9	-1.1	0.9	0.8	0.1
Medication: Metformin	0.7	1.0	3.5	-0.9	-1.8	-0.7	-0.6	-1.2	0.2	0.5	-0.8	-0.3	-0.1	-1.9	-1.1	-0.6
Diabetes (father)	0.7	0.9	4.8	1.5	0.8	2.2	-0.4	0.5	-0.6	-0.8	-0.3	0.2	-0.2	1.0	-0.3	-0.9
Diabetes (mother)	1.7	2.2	13.1	1.3	-3.6	1.8	0.5	-0.9	-0.5	1.0	-1.0	-1.8	-1.4	1.0	0.2	-0.8
Severe depression (siblings)	1.2	1.3	2.6	0.3	0.4	-0.4	-1.2	-1.1	-1.6	-1.4	-1.4	-1.2	-1.6	-0.6	-1.2	-1.3
Pack years adult smoking proportion	1.9	2.9	7.5	0.6	-2.0	1.8	2.7	1.7	1.1	1.5	1.3	0.6	0.5	2.7	2.1	1.6
Impedance of leg (right)	5.9	28.4	63.3	0.4	4.4	2.8	2.6	7.5	5.7	1.0	7.4	8.0	7.7	3.9	4.2	5.9
Leg fat-free mass (left)	2.5	13.5	30.1	-0.7	-1.0	-2.2	-1.2	-5.2	-4.3	-1.1	-5.2	-5.5	-5.5	-2.7	-2.9	-4.2
Trunk fat percentage	0.6	2.4	6.7	-0.5	-0.3	-0.8	-2.6	-1.4	-1.6	-1.7	-1.8	-0.9	-0.9	-1.5	-1.7	-2.6
Hand grip strength (right)	1.2	3.2	13.5	2.1	-0.4	-0.7	1.0	-1.7	-1.1	1.5	-1.4	-3.7	-3.1	1.4	1.4	-0.1
Townsend deprivation index at recruitment	1.1	1.5	5.2	0.1	-1.0	-0.1	1.9	-1.2	-1.4	0.3	-1.2	-2.2	-2.3	0.5	0.2	-0.0
Current tobacco smoking	5.0	8.1	22.3	1.9	-0.9	3.2	3.7	3.2	2.0	1.8	3.2	1.0	1.5	4.7	3.8	3.1
Average weekly fortified wine intake	0.2	0.2	0.6	-0.0	0.3	-0.0	-0.2	0.5	0.5	0.1	0.6	0.8	0.7	-0.2	-0.0	0.5
Maternal smoking around birth	1.2	1.7	6.9	1.6	-2.1	1.5	0.3	0.7	-0.8	-0.3	0.4	-1.1	-1.0	2.6	1.3	0.1
Fed-up feelings	0.5	1.0	2.3	1.0	1.5	0.2	-0.3	-0.8	-1.4	-1.0	-1.0	-1.0	-1.1	-0.4	-1.0	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.9	-0.6	0.8	1.0	0.7	0.4	-0.2	-0.1	0.4	-0.4	-0.5	1.4	0.6	0.5
Relative age voice broke	1.2	1.8	5.2	0.6	1.0	2.0	1.0	1.9	0.9	0.4	1.4	1.1	1.1	2.3	1.5	1.1
Taking other prescription medications	1.0	1.5	4.5	-0.9	0.5	-0.0	0.4	1.1	1.8	1.0	1.7	1.5	2.1	0.1	0.9	1.5
Age when periods started (menarche)	1.1	2.6	5.5	-1.5	2.1	0.8	0.5	2.2	1.2	-0.5	2.3	2.3	2.1	1.2	1.1	1.5
Bilateral oophorectomy (both ovaries removed)	2.4	2.8	6.6	0.3	-0.7	2.0	0.7	2.6	1.7	0.3	2.0	2.4	2.4	1.8	1.2	1.1
Heel bone mineral density (BMD) T-score, automated (left)	4.1	9.4	18.6	0.7	3.0	2.7	1.7	4.0	3.0	1.7	4.0	2.5	2.9	4.3	4.0	3.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.2	-0.8	-1.5	0.1	-0.1	-0.9	-0.7	-0.0	-0.7	-1.2	-1.1	-0.1	-0.4	-0.4
Qualifications: CSEs or equivalent	1.2	1.5	10.0	0.3	-3.2	0.1	-0.5	0.9	1.1	0.1	1.3	1.3	1.8	-0.4	0.2	0.8
Serious illness, injury or assault to yourself	1.6	2.0	4.1	0.0	1.9	1.2	1.4	1.3	1.4	1.3	1.5	0.6	0.8	2.0	1.9	1.6
High blood pressure	1.0	2.9	10.2	-1.4	-2.2	-0.9	-1.1	-2.0	-1.7	0.2	-1.8	-3.2	-2.5	0.4	0.3	-1.5
Hayfever, allergic rhinitis or eczema	1.1	2.4	8.4	-2.9	0.8	-2.8	-1.8	-0.5	0.5	-0.4	0.1	1.1	1.3	-2.6	-1.0	-0.3
Multivitamins +/- minerals	1.6	2.1	7.1	-0.5	1.1	1.2	-1.1	0.2	-0.5	-2.1	-0.5	1.9	1.2	-1.9	-2.7	-1.4
Stomach or abdominal pain in last month	2.8	3.5	15.6	1.6	1.8	3.9	0.5	2.3	-0.1	-1.2	1.7	1.1	0.8	3.2	1.2	0.8
Supplements: Glucosamine	0.3	0.4	1.9	1.2	-1.2	1.4	0.0	-0.0	-0.1	0.1	-0.4	-0.1	0.0	0.2	-0.4	-0.5
Diverticular disease/diverticulitis (self-reported)	3.7	4.4	11.0	1.9	0.6	2.6	2.2	2.5	1.5	1.3	2.3	1.2	1.2	3.3	2.7	2.3
Medication: Atenolol	0.7	0.9	6.2	2.5	-0.5	1.2	1.8	0.0	-0.2	0.1	-0.7	0.2	-0.4	0.2	-0.5	-0.2
Medication: Levothyroxine sodium	0.5	0.9	3.7	0.7	-1.8	1.9	-0.2	0.2	-0.9	-0.7	-0.3	-0.8	-0.7	1.2	0.0	-0.6
Sitting height	0.2	1.6	14.6	1.2	3.8	-0.0	1.4	0.0	0.1	0.7	-0.0	-0.5	-0.8	0.9	0.8	0.6
Chronic bronchitis/emphysema (father)	0.3	0.4	1.4	0.5	0.3	1.0	-1.2	-0.1	-0.3	-0.6	-0.3	-0.2	0.5	-0.1	-0.6	-1.1
High blood pressure (mother)	1.0	1.5	7.5	0.2	-2.7	-1.0	-1.1	-1.4	-0.6	0.1	-1.3	-1.3	-0.9	-1.2	-0.7	-1.0
Body mass index (BMI)	5.5	23.5	45.2	0.2	-3.7	-1.7	-3.6	-6.2	-5.7	-2.3	-6.7	-6.6	-6.6	-3.1	-4.1	-6.3
Impedance of leg (left)	5.6	27.3	60.0	0.6	4.9	3.0	2.1	7.4	5.5	0.9	7.2	7.7	7.5	3.9	4.0	5.5
Leg predicted mass (left)	2.5	13.4	30.3	-0.7	-1.0	-2.1	-1.2	-5.2	-4.3	-1.1	-5.2	-5.5	-5.5	-2.6	-2.9	-4.2
Trunk fat mass	1.3	5.6	12.6	-0.5	-0.3	-1.1	-2.7	-2.8	-2.8	-1.8	-3.2	-2.6	-2.6	-1.9	-2.3	-3.6
Waist circumference	4.0	14.8	28.5	-0.1	-2.8	-1.1	-3.5	-4.7	-4.6	-2.5	-5.2	-4.6	-4.7	-2.8	-3.7	-5.3
Number of incorrect matches in round	1.6	2.7	9.0	-2.2	-0.1	-1.5	-3.0	-1.7	-0.9	-0.8	-1.4	-1.0	-0.6	-2.1	-1.7	-2.0
Past tobacco smoking	0.5	1.0	3.5	0.5	1.9	0.4	-0.7	-0.7	-1.3	-1.0	-1.1	-0.7	-1.2	-0.3	-1.0	-1.2
Alcohol usually taken with meals	0.5	0.8	2.8	-1.2	0.7	-0.9	-1.7	-0.2	0.5	-0.2	-0.0	1.0	1.0	-1.5	-0.8	-0.5
Nervous feelings	1.5	2.8	6.2	-1.4	2.4	-0.1	-1.0	2.1	1.6	-0.1	2.4	2.2	2.5	0.9	1.2	1.5
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	8.0	-1.2	1.8	0.8	-0.1	2.4	1.6	0.4	2.8	1.4	2.2	2.2	2.2	2.0
Hearing difficulty/problems with background noise	0.2	0.4	2.1	-1.5	-1.0	0.5	-1.0	0.1	0.3	-0.0	0.2	0.2	0.5	-0.2	-0.2	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	2.4	1.0	-0.1	1.5	0.1	0.1	-0.4	0.3	-0.1	-1.0	-0.8	1.2	0.5	0.1
Had menopause	1.2	1.5	5.4	1.3	-1.7	0.5	0.4	0.2	-0.1	1.1	0.2	-1.7	-1.1	2.3	2.0	0.5
Had other major operations	0.9	1.1	2.7	-1.2	-1.4	0.7	1.1	0.9	0.8	-0.0	1.2	1.6	1.5	0.0	0.0	0.9
Forced vital capacity (FVC)	0.6	2.3	7.5	0.4	2.7	-1.5	1.3	0.5	1.1	1.7	1.3	-0.5	0.2	1.3	2.3	2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.5	13.8	0.2	2.8	2.8	0.8	3.7	2.1	0.4	3.2	2.9	2.7	3.6	2.7	2.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	0.3	0.8	0.8	0.7	0.7	0.7	0.8	1.0	0.1	0.3	1.2	1.1	1.0
Qualifications: None of the above	0.4	0.8	3.5	-0.8	-1.9	0.2	0.9	-0.7	0.9	1.5	-0.2	0.1	0.5	-1.1	-0.4	0.1
Financial difficulties in last 2 years	0.3	0.5	1.2	-0.4	-1.0	-1.1	-1.1	-0.2	-0.3	0.0	0.2	-1.0	-0.4	0.6	0.9	0.1
Mouth/teeth dental problems	2.0	3.1	7.3	-0.7	-1.1	-0.4	-2.2	-1.7	-1.7	-1.8	-2.2	-0.4	-1.4	-2.3	-2.7	-2.3
Heart attack	1.4	1.8	7.5	2.1	1.3	2.7	0.5	0.4	-1.5	-1.4	-0.4	-0.7	-1.2	1.8	-0.1	-0.5
Allergy	0.8	1.9	6.2	2.5	-0.9	2.0	1.3	0.2	-1.0	-0.1	-0.4	-1.3	-1.7	2.5	0.9	-0.1
Pain all over the body in last month	1.9	2.1	4.7	-0.4	0.0	1.6	0.4	1.7	2.0	0.9	1.9	1.8	2.2	1.1	1.1	1.5
Diabetes (self-reported)	0.4	0.5	2.2	-0.3	-1.5	0.5	-0.3	-0.8	0.2	0.3	-0.6	0.0	-0.0	-1.3	-1.2	-0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.4	-0.8	-0.9	-1.0	-1.5	-0.3	0.3	-0.3	0.2	0.6	0.7	-1.4	-0.7	-0.0
Medication: Ramipril	0.6	0.7	3.4	0.1	0.7	1.7	0.1	0.3	-0.0	0.5	0.0	-0.8	-0.8	1.8	1.0	0.1
Medication: Simvastatin	1.2	1.8	7.3	0.6	-2.1	0.7	-0.2	-1.5	-0.4	1.4	-1.2	-2.7	-1.9	0.8	0.5	-0.6
Fluid intelligence score	0.8	1.6	6.8	2.6	1.1	0.5	0.0	-0.5	-1.5	-0.8	-0.8	-1.7	-1.9	1.2	0.3	-0.4
Illnesses of siblings	0.6	0.9	3.5	-1.9	0.8	-0.8	-0.8	0.3	0.4	-0.7	0.6	1.2	1.2	-1.1	-0.6	0.0
Neuroticism score	0.7	1.5	3.8	-1.9	1.6	-0.6	-0.5	1.4	1.1	0.0	1.5	1.3	1.7	0.5	1.0	1.0
Weight	3.0	14.8	30.3	-0.3	-1.0	-1.8	-2.5	-5.1	-4.7	-1.8	-5.4	-5.5	-5.5	-2.5	-3.1	-4.9
Impedance of arm (right)	7.1	33.2	86.7	-0.6	3.9	1.9	2.8	7.8	6.9	1.6	7.8	9.3	9.1	2.6	3.8	6.4
Arm fat percentage (right)	2.4	9.3	21.0	-0.0	-2.2	-0.6	-3.1	-3.4	-3.6	-2.5	-4.2	-3.0	-3.3	-2.4	-3.4	-4.6
Trunk fat-free mass	2.4	13.9	36.3	0.1	-0.1	-1.4	-1.0	-5.2	-4.5	-1.0	-5.3	-6.0	-6.0	-2.0	-2.7	-4.2
Hip circumference	1.7	7.3	12.5	-1.9	-1.2	-2.3	-2.5	-3.5	-2.9	-1.2	-3.5	-3.5	-3.3	-2.2	-2.0	-3.3
Time employed in main current job	4.5	5.2	13.8	-2.2	-0.9	-3.7	-0.7	-3.3	-1.6	0.4	-2.7	-2.8	-2.6	-2.9	-1.4	-1.6
Alcohol intake versus 10 years previously	1.1	1.7	3.3	0.8	0.8	0.9	1.8	1.5	1.4	0.8	1.5	1.6	1.7	0.7	0.9	1.7
Father’s age at death	0.8	1.1	4.2	-1.1	0.2	-0.7	1.1	0.2	1.6	2.0	0.8	0.2	0.7	0.1	1.2	1.4
Worrier / anxious feelings	0.5	1.0	4.4	-2.1	1.2	-0.4	-0.3	0.5	1.3	0.8	0.7	1.0	1.3	-0.6	0.1	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	5.8	-0.1	2.4	1.1	0.9	1.1	1.0	0.8	1.4	0.5	1.0	1.1	1.0	1.5
Falls in the last year	3.1	4.2	9.7	-0.2	-0.2	0.8	0.9	2.4	2.5	1.7	3.1	1.5	2.6	2.0	2.7	2.8
Hair/balding pattern: Pattern 3	0.5	0.8	3.0	-1.5	1.7	-0.8	0.4	0.5	0.5	-0.3	0.5	1.4	1.0	-0.7	-0.3	0.5
Number of live births	3.2	4.5	10.0	1.2	-2.4	0.3	2.5	1.6	2.1	2.4	2.5	0.3	0.9	2.5	3.2	3.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	5.6	0.3	2.0	-2.4	0.4	-0.5	0.3	1.1	0.2	-0.9	-0.6	-0.0	1.1	1.1
Pulse rate	0.9	1.5	3.3	0.5	1.8	0.2	-1.3	-1.1	-1.5	-1.3	-1.1	-1.1	-1.6	-0.6	-1.4	-1.1
Happiness	0.7	0.9	2.4	-0.4	0.7	0.0	-0.8	-0.7	-1.6	-1.1	-0.9	-1.5	-1.4	0.2	-0.5	-1.0
Noisy workplace	0.7	0.8	3.2	-1.3	-0.9	0.1	1.7	-0.6	0.8	1.8	-0.3	-0.3	0.2	-0.6	-0.0	0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.9	-0.8	1.1	-1.2	-0.5	-1.6	-1.2	-0.5	-1.6	-1.4	-1.7	-1.1	-1.1	-1.2
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	6.3	1.5	-0.8	1.0	0.7	2.1	0.7	-0.1	2.2	0.8	1.5	2.5	2.1	1.5
Mouth/teeth dental problems: Dentures	0.9	1.4	3.2	1.4	-0.9	1.0	1.8	0.6	1.1	1.8	1.0	-0.1	0.7	1.3	1.5	1.3
Asthma	0.2	0.5	1.5	-0.7	0.5	-1.2	-0.2	-0.7	0.7	1.2	-0.1	-0.5	0.4	-1.1	-0.0	0.1
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	7.2	0.9	2.7	2.2	0.5	2.2	1.0	-0.4	1.9	1.9	1.8	1.7	0.8	1.4
Medication: Cholesterol lowering	0.5	0.8	2.9	-0.4	-1.3	-0.2	-1.0	-1.3	-0.5	0.4	-1.0	-1.7	-1.2	-0.2	-0.2	-0.7
Depression (self-reported)	0.2	0.3	2.3	0.5	1.5	-0.1	0.1	0.3	0.4	0.4	0.4	0.1	0.3	0.3	0.5	0.6
Medication: Lansoprazole	1.6	1.9	3.4	1.1	0.5	1.5	1.9	1.7	1.1	0.9	1.4	0.9	1.2	1.8	1.5	1.5
Prospective memory result	0.3	0.3	1.0	-0.6	0.4	1.0	-1.0	0.5	0.4	-0.2	0.3	0.8	0.6	0.2	-0.2	-0.2
Lung cancer (father)	0.4	0.5	2.1	0.3	0.9	1.4	0.7	0.1	-0.4	0.2	-0.0	-0.7	-0.7	1.1	0.3	0.3
Illnesses of mother	1.1	1.4	6.3	-0.0	2.5	0.9	1.1	1.4	0.7	0.1	1.2	1.4	0.9	1.0	0.6	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	6.5	0.9	2.5	-2.2	-0.1	-0.7	-0.2	0.6	-0.2	-1.1	-0.9	-0.2	0.7	0.4
Pulse wave Arterial Stiffness index	1.7	2.0	3.8	1.9	1.1	0.7	0.1	-1.7	-1.5	-0.5	-1.9	-1.6	-1.8	-1.1	-1.7	-1.3
Impedance of arm (left)	8.1	37.6	105.3	-0.9	4.0	1.6	2.8	8.2	7.4	1.5	8.3	10.3	10.0	2.2	3.7	6.7
Arm fat mass (right)	3.4	13.8	27.5	0.1	-2.1	-1.0	-3.0	-4.6	-4.5	-2.3	-5.2	-4.6	-4.8	-2.5	-3.5	-5.2
Trunk predicted mass	2.5	14.1	36.6	0.1	-0.1	-1.3	-1.1	-5.2	-4.6	-1.1	-5.3	-6.0	-6.1	-2.0	-2.8	-4.2
Standing height	0.5	5.0	27.8	-0.7	5.3	-0.1	2.0	2.0	1.9	0.8	2.3	2.3	2.2	0.8	1.5	2.3
Length of working week for main job	2.6	2.9	7.3	-1.4	0.0	-1.6	-2.2	-2.1	-1.0	-0.6	-2.0	-1.1	-0.9	-2.7	-2.1	-2.1
Exposure to tobacco smoke at home	1.5	1.6	5.6	-1.0	-0.1	-0.7	0.7	0.2	1.5	2.4	1.2	-0.8	0.5	1.1	2.2	1.8
Breastfed as a baby	0.6	0.8	1.6	0.2	1.1	0.7	0.8	0.6	1.1	1.2	1.0	0.6	0.4	0.7	0.9	1.3
Tense / ‘highly strung’	1.6	2.7	8.7	-2.1	3.0	-0.1	-1.3	1.9	1.3	-0.4	1.9	2.0	2.3	0.8	1.0	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	3.3	5.1	10.8	0.3	1.5	1.2	1.5	2.5	2.7	1.9	3.3	1.7	2.7	2.2	2.8	3.2
Hair/balding pattern: Pattern 4	1.4	3.4	8.3	-1.2	-2.9	-2.3	-1.5	-2.3	-1.4	0.1	-1.7	-2.9	-2.1	-1.2	-0.4	-1.5
Birth weight of first child	0.6	1.0	4.1	-0.4	1.2	-2.0	-0.4	-1.3	-0.3	0.1	-0.8	-0.6	-0.3	-1.9	-0.9	-0.5
Peak expiratory flow (PEF)	0.5	1.1	4.6	0.0	-0.2	-2.1	-0.6	-1.1	-0.8	-0.7	-0.8	-0.3	-0.6	-1.9	-1.2	-0.4
Pulse wave reflection index	1.5	1.8	3.7	1.3	1.3	0.4	-0.1	-1.4	-1.5	-1.1	-1.9	-1.0	-1.3	-1.2	-1.9	-1.8
Ever highly irritable/argumentative for 2 days	2.0	2.4	3.6	-0.4	0.2	1.6	1.7	1.7	1.9	1.6	1.8	1.4	1.7	1.7	1.6	1.7
Loud music exposure frequency	0.5	0.6	1.5	-0.7	0.5	-0.4	0.4	0.8	0.8	0.7	1.0	0.3	1.0	0.6	1.2	0.8
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.9	-0.3	-0.1	0.4	1.9	1.6	1.7	1.4	1.8	1.0	1.5	1.6	2.0	2.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.9	-0.5	0.2	-0.3	-0.6	0.3	0.1	0.1	0.5	-0.4	-0.0	0.9	1.0	0.3
Blood clot in the leg (DVT)	0.2	0.3	1.6	-1.3	-0.9	0.3	0.6	-0.3	0.2	0.3	0.0	0.0	0.3	-0.7	-0.5	0.2
Medication: Paracetamol	1.0	1.6	4.4	-1.5	1.7	1.5	0.3	1.4	0.5	-1.0	1.2	2.1	1.8	-0.3	-0.8	0.7
Headache pain in last month	1.6	2.7	8.0	1.3	1.8	1.9	2.3	2.1	0.9	-0.6	1.6	2.8	1.9	0.3	-0.5	1.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.6	1.4	1.1	0.3	1.6	1.3	0.8	0.4	1.2	1.2	1.0	0.8	0.9	1.3
Glaucoma (self-reported)	2.7	3.2	6.5	-0.5	1.8	0.6	0.6	2.1	1.9	1.2	2.5	1.6	1.8	2.1	2.4	2.3
Gout (self-reported)	0.3	0.3	1.5	-0.1	-0.6	1.2	-0.8	0.6	0.2	-0.2	0.4	0.4	0.4	1.0	0.3	-0.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.9	2.0	-1.2	1.7	-0.4	-0.0	-1.6	-1.6	-0.7	-0.7	-0.8	0.7	-0.8	-1.2
Medication: Amlodipine	4.3	6.0	12.2	0.7	-1.7	-0.5	-1.8	-3.0	-3.0	-1.5	-3.5	-3.1	-3.5	-1.5	-2.3	-3.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.8	-0.2	1.6	-1.3	-1.1	-0.9	0.1	0.2	-0.6	-0.3	0.1	-1.7	-0.8	-0.5
Birth weight	0.9	1.9	4.9	2.2	1.4	0.9	0.0	-0.6	-2.2	-1.8	-1.1	-1.3	-2.0	0.6	-0.7	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.2	1.1	0.8	0.4	0.4	0.3	-0.9	-1.5	-0.2	0.5	0.1	0.1	-0.8	-0.6
High blood pressure (siblings)	0.7	1.0	2.3	-0.0	-0.7	-0.9	-0.6	-1.3	-1.0	-0.1	-1.5	-1.5	-1.4	-0.7	-0.6	-1.1
Forced vital capacity (FVC), Best measure	0.6	2.0	5.6	0.8	2.4	-1.4	1.2	0.6	1.1	1.6	1.3	-0.5	0.3	1.4	2.3	1.9
Body fat percentage	1.2	4.7	11.6	-0.4	-0.9	-0.8	-2.9	-2.3	-2.5	-2.0	-2.8	-2.0	-2.1	-1.7	-2.2	-3.4
Leg fat percentage (right)	1.9	7.0	14.9	0.2	-1.7	-0.4	-2.8	-2.9	-3.4	-2.1	-3.5	-3.4	-3.4	-1.0	-2.1	-3.9
Arm fat-free mass (right)	3.3	16.7	42.4	0.1	-0.4	-1.5	-1.9	-5.6	-5.1	-1.5	-5.7	-6.5	-6.5	-2.0	-2.8	-4.8
Exposure to tobacco smoke outside home	1.8	2.3	8.8	-0.5	-1.5	1.5	0.6	1.7	0.9	0.8	1.9	0.0	0.8	3.0	2.4	1.5
Comparative body size at age 10	9.4	25.9	53.5	-2.2	-4.0	-5.5	-3.0	-7.3	-4.8	-0.7	-6.5	-7.2	-6.4	-5.1	-3.9	-5.0
Number of full brothers	4.0	5.1	13.7	0.4	-1.3	2.3	2.6	2.5	1.7	1.5	2.7	1.0	1.2	3.7	3.2	2.6
Worry too long after embarrassment	0.3	0.5	1.7	-1.3	-0.7	-0.2	-1.0	0.6	0.2	-0.7	0.5	0.6	1.1	-0.2	-0.2	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	4.7	-0.7	1.8	0.0	-0.2	1.4	1.9	0.8	1.9	1.8	2.2	0.2	1.0	1.7
Wheeze or whistling in the chest in last year	0.4	0.8	4.2	-2.0	0.4	-1.0	-0.1	-0.2	0.7	0.4	0.6	0.4	1.1	-1.4	-0.5	0.5
Number of children fathered	0.3	0.3	1.3	0.8	-0.1	1.1	0.1	-0.5	-0.3	0.2	-0.6	-0.6	-0.7	0.3	-0.3	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.1	15.0	-3.4	-0.2	-3.9	-2.1	-2.5	-0.3	0.8	-1.5	-1.9	-1.2	-2.7	-0.6	-0.8
Age at first live birth	3.1	5.6	9.6	-1.5	0.5	-2.0	-2.7	-2.6	-2.6	-2.2	-2.9	-1.9	-2.4	-2.4	-2.8	-3.1
Pulse wave peak to peak time	1.9	2.3	4.6	-2.1	-0.8	-1.0	0.2	1.6	1.7	0.8	2.0	1.6	1.8	1.1	1.9	1.5
Health satisfaction	0.7	1.0	2.4	-0.7	1.4	1.2	-1.0	1.3	0.6	-0.6	1.1	1.0	1.6	0.6	0.2	0.2
Shortness of breath walking on level ground	2.6	3.1	6.9	-1.5	1.0	0.4	0.0	1.8	2.4	1.3	2.6	1.9	2.6	1.0	1.8	2.1
Qualifications: College or University degree	1.0	3.1	6.7	-0.6	2.6	-1.5	-1.7	-1.6	-2.1	-1.9	-2.0	-1.4	-1.9	-1.3	-1.6	-1.9
Eye problems/disorders: None of the above	0.5	0.6	1.7	-0.1	-1.0	0.6	-0.5	0.8	-0.1	-1.2	0.5	1.3	1.3	-0.2	-0.6	-0.6
Mouth/teeth dental problems: Loose teeth	1.8	2.1	4.9	-0.7	0.0	0.0	0.5	1.4	1.8	1.5	2.2	0.6	1.7	1.5	2.2	2.1
Emphysema/chronic bronchitis	0.5	0.6	1.6	-0.6	-0.0	0.5	0.5	0.7	1.1	0.5	1.1	1.2	1.3	-0.2	0.1	0.7
Medication for pain relief, constipation, heartburn	3.9	6.6	13.8	-0.6	-3.0	-3.7	-2.1	-3.3	-2.2	-1.0	-3.0	-2.6	-2.7	-2.9	-1.9	-2.7
Neck or shoulder pain in last month	2.1	3.0	5.4	0.5	2.2	1.8	1.8	2.1	1.3	0.8	2.0	1.3	1.6	2.3	2.0	1.8
Medication: Blood pressure	0.5	0.9	2.0	-1.2	-0.8	-0.4	-1.4	-1.3	-0.7	-0.1	-1.1	-1.4	-1.1	-0.5	-0.5	-1.1
Angina (self-reported)	2.2	3.0	10.8	2.7	-0.0	2.2	1.9	1.1	0.5	1.3	0.9	-0.8	-0.3	3.3	2.4	1.2
Migraine (self-reported)	0.9	1.1	3.6	1.2	1.7	0.5	0.5	1.2	0.4	-0.7	0.8	1.9	1.3	-0.2	-0.3	0.6
Medication: Ibuprofen	3.3	4.0	8.8	0.9	3.0	2.5	0.5	2.7	1.4	-0.5	2.4	2.8	2.7	1.4	0.6	1.6
Medication: Allopurinol	0.9	1.1	4.6	1.0	0.5	2.1	-0.8	1.4	-0.2	-1.4	0.6	1.3	0.9	1.2	-0.1	-0.5
Medication: Omeprazole	4.2	5.0	10.9	1.4	1.5	3.3	1.2	3.0	1.6	0.4	2.9	2.0	2.0	3.3	2.2	2.1
Medication: Seretide 50 evohaler	0.5	0.5	2.4	-0.5	0.0	0.1	-0.1	0.9	0.5	-0.5	0.7	1.6	1.5	-0.6	-0.4	0.2
Mean time to correctly identify matches	0.5	1.0	6.8	-1.8	-2.6	-0.7	0.1	0.0	0.8	0.7	0.2	0.3	0.8	-0.5	0.2	0.1
Heart disease (mother)	1.2	1.4	5.1	0.4	-2.3	-0.8	-0.1	-1.1	-0.7	0.9	-0.9	-2.2	-1.8	0.8	1.0	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	6.6	-0.6	0.1	1.1	0.8	2.5	1.8	0.3	2.3	2.4	2.6	1.6	1.7	1.7
Whole body fat mass	2.3	9.4	19.0	-0.4	-1.1	-1.2	-2.9	-3.8	-3.7	-2.0	-4.3	-3.9	-3.9	-2.2	-2.8	-4.4
Leg fat mass (right)	3.1	12.1	22.9	-0.1	-1.8	-1.0	-2.9	-4.3	-4.4	-2.1	-4.8	-4.8	-4.8	-1.9	-2.8	-4.7
Arm predicted mass (right)	3.2	16.3	40.5	0.0	-0.2	-1.7	-1.7	-5.6	-5.0	-1.4	-5.7	-6.3	-6.4	-2.2	-2.9	-4.7
Pulse rate, automated reading	0.3	1.0	3.4	-0.2	1.9	0.3	-1.6	-0.5	-1.1	-1.3	-0.5	-0.6	-0.8	-0.3	-1.0	-0.9
Alcohol intake frequency.	0.2	0.5	1.4	-0.7	0.9	-0.2	-0.4	0.1	0.5	-0.2	-0.1	1.1	0.8	-1.2	-0.9	-0.2
Comparative height size at age 10	0.6	3.0	8.3	0.0	2.9	0.3	1.0	2.1	1.7	0.3	2.2	2.5	2.7	0.5	0.9	1.7
Number of full sisters	1.2	1.4	6.1	0.6	-2.5	1.3	1.1	0.9	0.4	0.8	1.1	-0.1	0.2	1.9	1.5	1.0
Suffer from ‘nerves’	3.2	5.0	11.2	-1.4	0.9	-0.2	1.2	2.4	2.8	2.4	3.0	1.4	2.4	2.3	3.3	2.9
Overall health rating	0.4	0.8	5.5	0.5	0.9	2.3	0.1	0.9	0.4	-0.0	0.8	0.5	0.6	1.1	0.4	0.5
Chest pain or discomfort	0.4	0.6	1.7	0.5	0.3	0.9	1.3	0.7	0.4	0.6	0.7	-0.1	0.1	1.3	1.1	1.0
Had major operations	2.6	3.0	9.7	2.3	0.2	3.1	2.0	2.2	1.0	-0.0	1.4	2.0	1.1	2.1	0.9	1.3
Age at last live birth	1.0	1.5	4.1	-0.8	0.6	-2.0	-1.4	-1.4	-1.0	-0.6	-1.3	-1.3	-1.3	-1.1	-0.9	-1.3
Family relationship satisfaction	0.9	1.1	2.6	0.4	1.4	0.4	0.2	-0.7	-1.6	-0.9	-1.4	-1.3	-1.6	0.1	-0.8	-1.2
Leg pain on walking	0.8	1.1	3.8	-2.0	-0.9	-0.2	0.6	0.4	1.5	1.6	0.8	0.4	1.0	0.3	1.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	0.9	-0.7	1.2	-1.2	-0.1	-0.7	-1.1	-0.3	-0.0	-0.1	-0.1	-0.9	-0.9
Commuting to job workplace: Car/motor vehicle	1.7	1.9	6.8	1.3	-0.3	0.4	0.6	1.5	1.6	0.1	1.6	2.6	2.6	-0.6	-0.0	1.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.7	-1.0	-0.5	-1.6	0.2	-1.5	0.3	1.6	-1.1	-1.3	-1.0	-1.1	0.0	-0.3
Medication: Aspirin	1.0	1.4	2.7	1.6	0.3	1.6	1.4	0.8	1.1	1.5	0.9	0.1	0.6	1.5	1.3	1.2
Supplements: Vitamin C	0.6	0.8	3.8	-0.0	1.9	-0.1	0.2	0.8	0.3	-0.8	0.7	1.5	1.2	-0.4	-0.5	0.3
Knee pain experienced in last month	0.1	0.2	0.8	0.3	0.0	0.9	0.5	0.5	-0.4	-0.6	-0.0	0.3	0.2	0.4	-0.2	-0.3
Hypertension (Self-reported)	1.1	3.0	11.4	-1.1	-2.2	-0.6	-1.0	-2.0	-1.8	0.1	-1.9	-3.4	-2.7	0.7	0.3	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.6	5.6	0.8	-0.9	2.0	2.0	2.2	2.0	1.5	2.4	1.3	2.0	2.3	2.1	2.1
Illnesses of father: Heart disease	1.5	2.0	5.8	2.4	1.4	2.4	0.3	0.2	-1.8	-1.9	-1.1	-0.0	-1.2	0.8	-1.2	-1.2
Illnesses of siblings: Diabetes	1.1	1.4	7.6	2.1	1.0	2.7	0.0	1.0	-0.0	-0.3	0.5	0.7	0.3	1.6	0.3	-0.0
Smoking status: Previous	0.3	0.4	1.3	-0.5	-1.1	-1.1	-0.1	-0.2	0.8	0.7	0.2	0.3	0.7	-1.0	-0.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	3.0	-1.6	1.7	-1.7	-0.6	-0.5	-0.2	-0.5	-0.4	0.2	-0.0	-1.4	-0.8	-0.2
Whole body fat-free mass	2.8	16.0	39.2	-0.2	-0.4	-1.8	-1.3	-5.6	-4.8	-1.3	-5.7	-6.2	-6.3	-2.5	-3.1	-4.6
Leg fat-free mass (right)	2.7	14.3	33.1	-0.6	-0.7	-2.2	-1.5	-5.4	-4.4	-1.1	-5.4	-5.8	-5.7	-2.7	-2.9	-4.3
Arm fat percentage (left)	2.2	8.6	19.3	-0.2	-2.2	-0.8	-3.0	-3.3	-3.4	-2.3	-4.0	-2.8	-3.1	-2.5	-3.3	-4.4
Average weekly red wine intake	1.5	2.3	7.7	-0.4	-1.7	-1.2	-2.8	-1.4	-1.7	-1.2	-1.1	-2.1	-1.7	-0.2	-0.3	-1.6
Handedness (chirality/laterality): Left-handed	4.5	5.4	12.5	0.5	1.1	-0.6	-1.6	-2.8	-3.1	-1.7	-3.2	-2.9	-3.5	-1.4	-2.3	-2.7
Mood swings	0.6	1.1	2.8	-1.7	1.4	0.2	-1.3	1.2	0.5	-0.9	1.1	1.3	1.6	0.2	0.1	0.1
Loneliness, isolation	0.2	0.3	1.0	0.4	0.4	-0.4	0.3	0.7	0.2	-0.0	0.8	0.1	0.2	1.0	1.0	0.8
Long-standing illness, disability or infirmity	0.3	0.4	1.3	-0.8	-0.5	1.1	-0.7	-0.8	-0.2	0.1	-0.6	-0.7	-0.5	-0.3	-0.7	-0.6
Ever had bowel cancer screening	1.2	1.4	4.2	-0.3	1.8	0.9	-0.5	1.7	0.7	-0.8	1.4	2.1	1.8	0.5	0.2	0.5
Diabetes diagnosed by doctor	0.4	0.6	2.6	-1.0	-1.3	-0.2	-0.6	-0.7	0.7	0.5	-0.2	0.5	0.5	-1.6	-1.0	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.8	0.6	-0.4	0.6	0.3	0.2	-1.3	-1.3	-0.4	-0.4	-0.7	0.8	-0.2	-0.7
Friendships satisfaction	2.7	3.3	7.9	0.6	0.2	0.8	-1.6	-1.2	-2.6	-2.8	-2.0	-1.1	-1.5	-1.3	-2.7	-2.5
Qualifications: nursing, teaching	0.2	0.4	1.4	1.2	0.3	0.1	0.3	-0.5	-0.6	-0.2	-0.7	-0.8	-1.0	-0.0	-0.3	-0.4
Commuting to job workplace: Walk	0.5	0.5	1.4	-0.8	0.4	-0.6	0.9	-0.1	0.4	1.2	0.3	-0.8	-0.3	0.7	1.2	0.6
Eye problems/disorders: Cataract	0.5	0.6	3.5	0.1	1.9	-0.9	0.4	-0.7	0.6	0.9	-0.2	-0.1	-0.3	-0.9	-0.1	0.5
Mouth/teeth dental problems: Mouth ulcers	3.0	4.8	8.7	-2.2	2.2	-0.9	1.8	2.3	2.5	1.2	2.9	2.4	2.9	0.8	2.0	2.8
Medication for cholesterol	0.9	1.4	4.3	-0.7	2.1	-0.5	-0.8	-0.1	-0.1	-1.3	-0.2	1.5	0.8	-2.0	-1.9	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.2	-1.3	0.6	-0.2	1.0	0.8	1.4	1.2	1.3	0.6	1.1	0.8	1.4	1.5
Back pain experienced in last month	1.3	1.9	4.8	-0.1	1.9	1.5	2.0	1.4	0.6	0.8	1.2	0.4	0.3	2.2	1.7	1.5
Mineral and other dietary supplements	0.5	0.6	2.0	-0.4	0.6	-1.3	0.1	-0.6	-0.6	0.2	-0.3	-1.4	-1.4	0.5	0.9	0.1
Breast cancer (self-reported)	4.5	5.4	16.2	-1.6	-2.4	-0.5	-0.0	2.3	3.2	1.8	3.1	2.7	4.0	0.3	2.0	2.3
Asthma (self-reported)	0.3	0.5	1.6	-0.6	0.5	-1.2	-0.3	-0.9	0.4	1.1	-0.3	-0.9	0.0	-1.1	-0.2	-0.1
Osteoporosis (self-reported)	0.8	1.0	2.5	0.8	0.9	1.4	-0.8	-0.4	-1.1	-1.5	-0.8	0.0	-0.5	-0.5	-1.6	-1.2
Osteoarthritis (self-reported)	1.8	2.3	5.1	0.2	1.8	1.7	-0.9	2.3	0.9	-0.9	2.1	2.1	2.2	1.4	0.8	0.7
Medication: Aspirin	1.0	1.3	2.9	1.7	-0.2	1.6	1.5	0.4	0.9	1.7	0.5	-0.4	0.0	1.5	1.3	1.1
Medication: Gliclazide	1.7	1.9	5.9	-1.1	-1.3	-1.4	-1.4	-2.0	-0.4	0.2	-1.7	-0.8	-0.9	-2.4	-1.6	-1.3
Illnesses of father: None of the above (group 1)	0.4	0.5	2.0	-1.0	-1.2	-1.4	-0.4	-0.5	0.2	0.6	0.2	-0.6	-0.1	-0.4	0.4	0.2
Smoking status: Current	3.5	5.5	15.8	1.3	-0.9	2.7	3.2	2.6	1.5	1.6	2.6	0.6	1.0	4.0	3.2	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	9.8	0.1	0.5	-3.1	-1.8	-1.9	-0.6	0.8	-0.9	-2.7	-1.8	-0.5	0.7	-0.2
Whole body water mass	2.9	16.3	39.9	-0.2	-0.3	-1.8	-1.5	-5.6	-4.9	-1.3	-5.7	-6.3	-6.3	-2.4	-3.1	-4.6
Leg predicted mass (right)	2.6	13.9	31.8	-0.7	-0.8	-2.2	-1.4	-5.3	-4.3	-1.1	-5.3	-5.6	-5.6	-2.7	-2.9	-4.3
Arm fat mass (left)	3.5	14.2	28.5	0.1	-2.2	-1.0	-3.1	-4.6	-4.6	-2.5	-5.3	-4.4	-4.8	-2.7	-3.8	-5.3
Number of self-reported non-cancer illnesses	0.2	0.3	1.9	0.2	0.1	1.4	0.4	0.5	0.5	0.4	0.4	0.3	0.5	0.7	0.2	0.2
Average weekly champagne plus white wine intake	1.9	2.6	6.5	-0.0	2.5	1.9	-1.7	1.6	-0.1	-2.4	0.9	2.5	1.8	0.1	-1.2	-0.7
Miserableness	0.7	1.2	2.3	-0.5	0.8	0.7	1.1	1.2	1.5	1.3	1.3	0.9	1.0	1.0	1.1	1.5
Guilty feelings	1.1	1.6	4.2	-2.1	1.9	-2.1	0.9	-0.2	1.4	1.4	0.6	0.3	0.7	-1.1	0.4	1.3
Wears glasses or contact lenses	0.5	0.6	3.8	1.2	2.0	0.5	1.1	-0.2	-0.2	-0.0	-0.4	-0.1	-0.4	-0.3	-0.6	-0.2
Ever taken oral contraceptive pill	0.9	1.0	4.2	-2.1	-0.2	-1.2	1.0	-0.0	1.0	1.4	0.8	-0.1	0.4	-0.2	0.8	1.3
Hearing aid user	0.5	0.6	2.8	-0.5	-0.2	-0.8	-0.6	-1.1	0.2	0.6	-0.8	-0.4	-0.2	-1.7	-0.9	-0.5
Mother’s age at death	0.3	0.3	1.1	0.1	-0.9	0.9	1.0	-0.2	0.3	0.9	-0.0	-0.6	-0.3	0.4	0.3	0.4
Financial situation satisfaction	1.2	1.4	4.7	0.8	0.9	1.8	-1.3	0.5	-1.7	-2.2	-0.3	-0.5	-0.6	1.3	-0.5	-1.4
Tinnitus: Yes, now most or all of the time	3.2	3.8	6.8	0.1	1.5	0.8	2.3	2.3	2.1	1.3	2.6	2.2	2.2	1.6	2.0	2.6
Commuting to job workplace: Public transport	0.5	0.6	1.9	-0.6	-0.9	0.2	0.3	-0.1	-0.5	0.2	-0.1	-1.2	-1.3	1.4	0.9	0.1
Eye problems/disorders: Glaucoma	3.6	4.2	9.3	0.2	1.5	1.3	1.1	2.5	2.0	1.5	2.7	1.2	1.6	3.0	3.1	2.6
Medication: Blood pressure	1.4	2.7	9.8	0.3	-1.2	0.3	-0.5	-1.7	-2.1	-0.4	-2.0	-3.1	-2.8	0.8	-0.1	-1.8
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.9	0.3	1.4	1.7	-0.3	1.0	0.0	-0.6	0.6	0.7	0.6	0.9	0.1	-0.0
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.5	1.4	0.9	2.1	-0.9	0.8	-0.4	-1.8	-0.0	1.6	1.1	-0.3	-1.5	-1.0
High cholesterol (Self-reported)	0.7	1.3	4.0	-1.4	-2.0	-0.5	-1.5	-1.5	-0.1	0.9	-0.8	-1.7	-0.9	-0.3	0.0	-0.7
Medication: Bendroflumethiazide	0.5	0.7	2.3	-1.1	-0.5	-0.5	-0.4	-1.1	-0.6	0.2	-1.0	-1.5	-1.3	0.0	0.0	-0.7
Medication: Paracetamol	1.0	1.5	4.3	-1.6	1.5	0.6	0.4	1.1	0.8	-0.5	1.2	2.1	2.0	-0.8	-0.7	0.9
Medication: Lisinopril	0.3	0.4	1.4	-0.6	-0.8	-0.3	-0.0	-0.4	-0.6	0.1	-0.5	-1.2	-1.0	0.8	0.7	-0.3
Medication: Atorvastatin	0.6	0.8	3.4	-1.1	-1.8	-1.3	-1.0	-0.5	0.3	0.7	0.3	-0.9	0.1	-0.1	0.8	0.2
Illnesses of father: High blood pressure	0.9	1.1	4.2	0.2	0.4	-1.2	0.9	-1.3	-0.5	1.0	-1.1	-2.0	-1.6	-0.1	0.4	0.2
Alcohol drinker status: Never	2.8	3.3	9.1	-2.0	-1.4	-3.0	-1.5	-2.3	-1.2	0.6	-1.8	-3.0	-2.2	-1.1	-0.0	-1.1
Ever smoked	1.5	2.7	5.9	1.1	-1.4	1.5	1.0	2.1	1.5	0.8	2.1	1.1	1.6	2.4	2.1	1.6
Basal metabolic rate	2.9	15.9	37.2	-0.2	-0.5	-1.8	-1.6	-5.5	-4.8	-1.4	-5.7	-6.1	-6.1	-2.5	-3.1	-4.7
Leg fat percentage (left)	2.1	7.6	17.0	0.3	-1.4	-0.1	-3.2	-3.0	-3.5	-2.1	-3.6	-3.6	-3.5	-0.9	-2.1	-4.1
Arm fat-free mass (left)	3.4	17.3	43.8	0.3	-0.3	-1.2	-1.8	-5.5	-5.3	-1.7	-5.9	-6.5	-6.6	-1.9	-3.0	-5.0
Number of operations (self-reported)	3.2	4.7	12.4	0.6	-1.2	3.2	1.2	3.3	1.1	-1.3	2.6	3.5	2.8	2.0	0.6	1.4
Average weekly beer plus cider intake	1.0	1.4	5.0	0.7	-2.2	-0.3	1.4	1.2	0.3	0.1	1.3	0.3	0.5	1.7	1.6	1.4
Irritability	0.7	1.3	2.5	-1.2	1.6	-0.9	-1.3	-0.8	-1.2	-1.4	-1.0	-0.6	-0.5	-1.0	-1.2	-1.3
Risk taking	1.0	1.4	4.0	-1.2	-0.6	1.4	-1.3	0.2	-0.2	-1.4	-0.3	1.7	1.1	-1.2	-2.0	-1.2
Ever had prostate specific antigen (PSA) test	2.8	3.2	8.2	-0.1	0.8	-0.0	-2.4	-1.7	-2.0	-2.0	-2.2	-1.0	-1.2	-1.7	-2.5	-2.9
Fractured/broken bones in last 5 years	0.2	0.3	1.2	0.0	-0.5	1.1	0.3	0.5	0.4	-0.0	0.6	1.0	0.5	0.0	-0.2	0.5
Age started oral contraceptive pill	0.3	0.4	1.6	-0.7	-1.3	-0.1	0.2	-0.8	-0.3	0.1	-0.8	-0.6	-0.5	-0.6	-0.7	-0.6
Diastolic blood pressure, automated reading	3.7	11.6	30.6	1.5	0.1	-0.1	-1.8	-4.3	-4.3	-1.7	-4.9	-4.8	-5.5	-1.6	-3.1	-3.9
Ever depressed for a whole week	2.5	3.1	7.3	-0.2	1.4	0.3	1.2	1.6	2.1	2.0	2.4	0.7	1.5	1.9	2.7	2.6
Unable to work because of sickness or disability	0.5	0.6	2.0	-1.4	-0.8	-0.2	1.0	0.5	0.7	0.6	0.8	0.7	0.7	0.2	0.6	0.9
Commuting to job workplace: Cycle	4.3	5.2	12.1	-0.7	-1.1	-2.8	-1.6	-3.5	-1.6	0.4	-3.0	-3.2	-3.0	-2.3	-1.4	-2.3
Myopia	0.8	1.1	5.5	0.6	-0.4	0.2	-0.0	0.2	-0.7	0.2	0.1	-1.7	-1.4	2.3	1.8	0.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	8.7	0.3	1.9	-0.0	0.2	1.6	1.5	-0.3	1.6	3.0	2.5	-1.0	-0.5	1.1
Cholesterol lowering medication	0.5	0.8	2.4	0.6	-1.5	0.8	-0.4	0.0	0.1	0.7	0.2	-1.3	-0.4	1.5	1.3	0.0
Medication: Omeprazole (e.g. Zanprol)	4.3	5.2	11.4	0.9	1.3	3.1	1.0	3.1	1.9	0.8	3.0	1.9	2.3	3.4	2.5	2.2
Pain experienced in last month	2.1	3.6	9.7	-1.4	-1.8	-3.1	-2.5	-2.5	-0.7	-0.1	-1.7	-1.6	-1.2	-2.7	-1.4	-1.6
Supplements: Calcium	0.9	1.0	5.2	-0.4	0.5	-0.4	-0.6	-1.0	-0.0	-0.4	-0.7	0.5	0.4	-2.3	-1.9	-0.6
Basal cell carcinoma (self-reported)	0.5	0.6	2.8	0.6	0.8	-0.8	0.2	-0.8	-0.7	0.3	-0.4	-1.7	-1.3	0.2	0.5	0.1
Heart attack/myocardial infarction (self-reported)	1.6	2.0	8.4	2.4	1.3	2.9	0.6	0.6	-1.3	-1.3	-0.3	-0.7	-1.1	2.1	0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.5	-1.6	-1.3	-0.2	0.6	-0.4	0.3	0.6	-0.0	-0.2	0.2	-0.8	-0.3	0.3
Heart disease (siblings)	1.4	1.7	5.3	2.1	-0.7	0.9	2.3	0.2	0.1	1.4	0.0	-1.1	-1.1	1.9	1.5	0.9
Alcohol drinker status: Previous	1.6	1.9	3.8	-0.3	1.1	0.9	0.9	2.0	1.4	0.6	1.7	1.9	1.6	1.5	1.4	1.4
Pack years of smoking	1.8	2.6	6.1	0.7	-1.7	2.0	2.5	1.9	1.1	1.1	1.4	1.2	0.9	2.4	1.7	1.5
Impedance of whole body	7.8	39.6	103.2	-0.4	5.1	2.5	2.3	8.7	7.2	1.1	8.6	10.2	9.9	3.2	4.2	6.7
Leg fat mass (left)	3.2	12.4	23.7	-0.1	-1.6	-1.0	-3.0	-4.4	-4.4	-2.1	-4.9	-4.9	-4.8	-1.9	-2.9	-4.9
Arm predicted mass (left)	3.5	17.7	43.5	0.3	-0.3	-1.4	-1.8	-5.8	-5.2	-1.5	-6.0	-6.5	-6.6	-2.2	-3.2	-5.0