TWAS hub - ADSL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1180	0.0420	6.3e-06	0.038	0.048	0.038	0.052	0.042	2.0e-05	1.6e-06	0.00002	5.7e-07	6.1e-06
2	GTEx	Adipose Visceral Omentum	0.1520	0.0640	2.8e-03	0.015	NA	0.022	NA	0.005	5.4e-02	NA	0.02400	NA	1.6e-01
3	GTEx	Testis	0.1790	0.0800	9.9e-03	0.129	NA	0.063	NA	0.095	2.5e-06	NA	0.00091	NA	5.2e-05
4	TCGA	Breast Invasive Carcinoma	0.0500	0.0256	3.2e-05	0.006	0.009	0.015	NA	0.008	2.1e-02	4.4e-03	0.00042	NA	6.9e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0438	0.0253	1.4e-03	0.030	0.027	0.032	NA	0.022	2.2e-04	4.8e-04	0.00016	NA	1.3e-03
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0710	0.0380	2.1e-04	0.021	0.053	0.025	NA	0.023	2.2e-02	5.2e-04	0.01300	NA	1.7e-02
7	TCGA	Liver Hepatocellular Carcinoma	0.0580	0.0350	3.6e-03	0.006	0.032	0.005	NA	0.005	1.7e-01	1.1e-02	0.18000	NA	1.8e-01
8	TCGA	Lung Adenocarcinoma	0.0341	0.0218	4.0e-03	0.004	0.013	0.005	NA	0.005	1.0e-01	8.9e-03	0.08100	NA	8.1e-02
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0650	0.0400	8.8e-03	0.016	0.024	0.023	NA	0.026	2.6e-02	8.9e-03	0.01000	NA	6.7e-03
10	TCGA	Pancreatic Adenocarcinoma	0.0880	0.0540	8.1e-03	0.029	0.008	0.008	NA	0.015	2.2e-02	1.5e-01	0.14000	NA	7.7e-02
11	TCGA	Prostate Adenocarcinoma	0.0801	0.0459	1.0e-03	0.016	0.016	0.021	NA	0.000	6.9e-03	8.3e-03	0.00230	NA	3.1e-01
12	TCGA	Soft Tissue Sarcoma	0.1430	0.0760	5.8e-06	0.045	0.055	0.054	NA	0.062	1.1e-03	3.3e-04	0.00039	NA	1.5e-04
13	TCGA	Stomach Adenocarcinoma	0.0450	0.0260	7.2e-04	-0.002	0.031	0.006	NA	0.007	4.4e-01	2.6e-03	0.11000	NA	9.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Breast Cancer	17.2	41.3	87.0	3.5	1.8	0.0	-2.9	-6.6	-9.3	-7.1	-8.6	-5.7	-8.7	-4.4	-8.2	-8.1
Comparative body size at age 10	9.4	25.9	53.5	-2.2	-4.0	-5.5	-3.0	-7.3	-4.8	-0.7	-6.5	-7.2	-6.4	-5.1	-3.9	-5.0
Impedance of arm (left)	8.1	37.6	105.3	-0.9	4.0	1.6	2.8	8.2	7.4	1.5	8.3	10.3	10.0	2.2	3.7	6.7
Impedance of whole body	7.8	39.6	103.2	-0.4	5.1	2.5	2.3	8.7	7.2	1.1	8.6	10.2	9.9	3.2	4.2	6.7
Impedance of arm (right)	7.1	33.2	86.7	-0.6	3.9	1.9	2.8	7.8	6.9	1.6	7.8	9.3	9.1	2.6	3.8	6.4
BMI	6.7	38.8	73.0	0.6	-4.4	-1.9	-5.4	-7.8	-7.4	-3.8	-8.5	-7.7	-8.0	-4.5	-6.0	-8.3
Impedance of leg (right)	5.9	28.4	63.3	0.4	4.4	2.8	2.6	7.5	5.7	1.0	7.4	8.0	7.7	3.9	4.2	5.9
Chronotype (morning person)	5.8	13.4	28.1	-1.0	-1.3	-2.1	-3.8	-5.2	-2.5	-0.9	-5.1	-3.0	-3.2	-5.3	-4.8	-4.8
Impedance of leg (left)	5.6	27.3	60.0	0.6	4.9	3.0	2.1	7.4	5.5	0.9	7.2	7.7	7.5	3.9	4.0	5.5
Body mass index (BMI)	5.5	23.5	45.2	0.2	-3.7	-1.7	-3.6	-6.2	-5.7	-2.3	-6.7	-6.6	-6.6	-3.1	-4.1	-6.3
Current tobacco smoking	5.0	8.1	22.3	1.9	-0.9	3.2	3.7	3.2	2.0	1.8	3.2	1.0	1.5	4.7	3.8	3.1
Time employed in main current job	4.5	5.2	13.8	-2.2	-0.9	-3.7	-0.7	-3.3	-1.6	0.4	-2.7	-2.8	-2.6	-2.9	-1.4	-1.6
Handedness (chirality/laterality): Left-handed	4.5	5.4	12.5	0.5	1.1	-0.6	-1.6	-2.8	-3.1	-1.7	-3.2	-2.9	-3.5	-1.4	-2.3	-2.7
Breast cancer (self-reported)	4.5	5.4	16.2	-1.6	-2.4	-0.5	-0.0	2.3	3.2	1.8	3.1	2.7	4.0	0.3	2.0	2.3
Medication: Amlodipine	4.3	6.0	12.2	0.7	-1.7	-0.5	-1.8	-3.0	-3.0	-1.5	-3.5	-3.1	-3.5	-1.5	-2.3	-3.1
Commuting to job workplace: Cycle	4.3	5.2	12.1	-0.7	-1.1	-2.8	-1.6	-3.5	-1.6	0.4	-3.0	-3.2	-3.0	-2.3	-1.4	-2.3
Medication: Omeprazole (e.g. Zanprol)	4.3	5.2	11.4	0.9	1.3	3.1	1.0	3.1	1.9	0.8	3.0	1.9	2.3	3.4	2.5	2.2
Medication: Omeprazole	4.2	5.0	10.9	1.4	1.5	3.3	1.2	3.0	1.6	0.4	2.9	2.0	2.0	3.3	2.2	2.1
Heel bone mineral density (BMD) T-score, automated (left)	4.1	9.4	18.6	0.7	3.0	2.7	1.7	4.0	3.0	1.7	4.0	2.5	2.9	4.3	4.0	3.1
Waist circumference	4.0	14.8	28.5	-0.1	-2.8	-1.1	-3.5	-4.7	-4.6	-2.5	-5.2	-4.6	-4.7	-2.8	-3.7	-5.3
Number of full brothers	4.0	5.1	13.7	0.4	-1.3	2.3	2.6	2.5	1.7	1.5	2.7	1.0	1.2	3.7	3.2	2.6
Medication for pain relief, constipation, heartburn	3.9	6.6	13.8	-0.6	-3.0	-3.7	-2.1	-3.3	-2.2	-1.0	-3.0	-2.6	-2.7	-2.9	-1.9	-2.7
Diverticular disease/diverticulitis (self-reported)	3.7	4.4	11.0	1.9	0.6	2.6	2.2	2.5	1.5	1.3	2.3	1.2	1.2	3.3	2.7	2.3
Diastolic blood pressure, automated reading	3.7	11.6	30.6	1.5	0.1	-0.1	-1.8	-4.3	-4.3	-1.7	-4.9	-4.8	-5.5	-1.6	-3.1	-3.9
Eye problems/disorders: Glaucoma	3.6	4.2	9.3	0.2	1.5	1.3	1.1	2.5	2.0	1.5	2.7	1.2	1.6	3.0	3.1	2.6
Body Mass Index (BMI) (2010)	3.5	4.8	9.9	-0.4	-0.5	-1.2	-3.1	-3.2	-1.9	-0.5	-2.8	-3.1	-2.6	-1.7	-1.6	-2.7
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.1	15.0	-3.4	-0.2	-3.9	-2.1	-2.5	-0.3	0.8	-1.5	-1.9	-1.2	-2.7	-0.6	-0.8
Smoking status: Current	3.5	5.5	15.8	1.3	-0.9	2.7	3.2	2.6	1.5	1.6	2.6	0.6	1.0	4.0	3.2	2.6
Arm fat mass (left)	3.5	14.2	28.5	0.1	-2.2	-1.0	-3.1	-4.6	-4.6	-2.5	-5.3	-4.4	-4.8	-2.7	-3.8	-5.3
Arm predicted mass (left)	3.5	17.7	43.5	0.3	-0.3	-1.4	-1.8	-5.8	-5.2	-1.5	-6.0	-6.5	-6.6	-2.2	-3.2	-5.0
Arm fat mass (right)	3.4	13.8	27.5	0.1	-2.1	-1.0	-3.0	-4.6	-4.5	-2.3	-5.2	-4.6	-4.8	-2.5	-3.5	-5.2
Arm fat-free mass (left)	3.4	17.3	43.8	0.3	-0.3	-1.2	-1.8	-5.5	-5.3	-1.7	-5.9	-6.5	-6.6	-1.9	-3.0	-5.0
Seen doctor (GP) for nerves, anxiety, tension or depression	3.3	5.1	10.8	0.3	1.5	1.2	1.5	2.5	2.7	1.9	3.3	1.7	2.7	2.2	2.8	3.2
Arm fat-free mass (right)	3.3	16.7	42.4	0.1	-0.4	-1.5	-1.9	-5.6	-5.1	-1.5	-5.7	-6.5	-6.5	-2.0	-2.8	-4.8
Medication: Ibuprofen	3.3	4.0	8.8	0.9	3.0	2.5	0.5	2.7	1.4	-0.5	2.4	2.8	2.7	1.4	0.6	1.6
Number of live births	3.2	4.5	10.0	1.2	-2.4	0.3	2.5	1.6	2.1	2.4	2.5	0.3	0.9	2.5	3.2	3.1
Arm predicted mass (right)	3.2	16.3	40.5	0.0	-0.2	-1.7	-1.7	-5.6	-5.0	-1.4	-5.7	-6.3	-6.4	-2.2	-2.9	-4.7
Suffer from ‘nerves’	3.2	5.0	11.2	-1.4	0.9	-0.2	1.2	2.4	2.8	2.4	3.0	1.4	2.4	2.3	3.3	2.9
Tinnitus: Yes, now most or all of the time	3.2	3.8	6.8	0.1	1.5	0.8	2.3	2.3	2.1	1.3	2.6	2.2	2.2	1.6	2.0	2.6
Number of operations (self-reported)	3.2	4.7	12.4	0.6	-1.2	3.2	1.2	3.3	1.1	-1.3	2.6	3.5	2.8	2.0	0.6	1.4
Leg fat mass (left)	3.2	12.4	23.7	-0.1	-1.6	-1.0	-3.0	-4.4	-4.4	-2.1	-4.9	-4.9	-4.8	-1.9	-2.9	-4.9
Falls in the last year	3.1	4.2	9.7	-0.2	-0.2	0.8	0.9	2.4	2.5	1.7	3.1	1.5	2.6	2.0	2.7	2.8
Age at first live birth	3.1	5.6	9.6	-1.5	0.5	-2.0	-2.7	-2.6	-2.6	-2.2	-2.9	-1.9	-2.4	-2.4	-2.8	-3.1
Leg fat mass (right)	3.1	12.1	22.9	-0.1	-1.8	-1.0	-2.9	-4.3	-4.4	-2.1	-4.8	-4.8	-4.8	-1.9	-2.8	-4.7
Weight	3.0	14.8	30.3	-0.3	-1.0	-1.8	-2.5	-5.1	-4.7	-1.8	-5.4	-5.5	-5.5	-2.5	-3.1	-4.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.6	5.6	0.8	-0.9	2.0	2.0	2.2	2.0	1.5	2.4	1.3	2.0	2.3	2.1	2.1
Mouth/teeth dental problems: Mouth ulcers	3.0	4.8	8.7	-2.2	2.2	-0.9	1.8	2.3	2.5	1.2	2.9	2.4	2.9	0.8	2.0	2.8
Relative age of first facial hair	2.9	6.0	14.4	0.8	1.6	2.6	1.7	3.5	1.9	0.5	3.1	2.4	2.4	3.8	2.9	2.4
Whole body water mass	2.9	16.3	39.9	-0.2	-0.3	-1.8	-1.5	-5.6	-4.9	-1.3	-5.7	-6.3	-6.3	-2.4	-3.1	-4.6
Basal metabolic rate	2.9	15.9	37.2	-0.2	-0.5	-1.8	-1.6	-5.5	-4.8	-1.4	-5.7	-6.1	-6.1	-2.5	-3.1	-4.7
Stomach or abdominal pain in last month	2.8	3.5	15.6	1.6	1.8	3.9	0.5	2.3	-0.1	-1.2	1.7	1.1	0.8	3.2	1.2	0.8
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.5	13.8	0.2	2.8	2.8	0.8	3.7	2.1	0.4	3.2	2.9	2.7	3.6	2.7	2.0
Whole body fat-free mass	2.8	16.0	39.2	-0.2	-0.4	-1.8	-1.3	-5.6	-4.8	-1.3	-5.7	-6.2	-6.3	-2.5	-3.1	-4.6
Alcohol drinker status: Never	2.8	3.3	9.1	-2.0	-1.4	-3.0	-1.5	-2.3	-1.2	0.6	-1.8	-3.0	-2.2	-1.1	-0.0	-1.1
Ever had prostate specific antigen (PSA) test	2.8	3.2	8.2	-0.1	0.8	-0.0	-2.4	-1.7	-2.0	-2.0	-2.2	-1.0	-1.2	-1.7	-2.5	-2.9
Glaucoma (self-reported)	2.7	3.2	6.5	-0.5	1.8	0.6	0.6	2.1	1.9	1.2	2.5	1.6	1.8	2.1	2.4	2.3
Leg fat-free mass (right)	2.7	14.3	33.1	-0.6	-0.7	-2.2	-1.5	-5.4	-4.4	-1.1	-5.4	-5.8	-5.7	-2.7	-2.9	-4.3
Friendships satisfaction	2.7	3.3	7.9	0.6	0.2	0.8	-1.6	-1.2	-2.6	-2.8	-2.0	-1.1	-1.5	-1.3	-2.7	-2.5
Lung FEV1/FVC ratio	2.6	13.1	26.5	0.1	-0.7	-2.7	-2.4	-4.8	-4.2	-2.2	-5.2	-3.7	-5.0	-3.8	-4.0	-4.1
Length of working week for main job	2.6	2.9	7.3	-1.4	0.0	-1.6	-2.2	-2.1	-1.0	-0.6	-2.0	-1.1	-0.9	-2.7	-2.1	-2.1
Shortness of breath walking on level ground	2.6	3.1	6.9	-1.5	1.0	0.4	0.0	1.8	2.4	1.3	2.6	1.9	2.6	1.0	1.8	2.1
Had major operations	2.6	3.0	9.7	2.3	0.2	3.1	2.0	2.2	1.0	-0.0	1.4	2.0	1.1	2.1	0.9	1.3
Leg predicted mass (right)	2.6	13.9	31.8	-0.7	-0.8	-2.2	-1.4	-5.3	-4.3	-1.1	-5.3	-5.6	-5.6	-2.7	-2.9	-4.3
Worry (Nagel 2018)	2.5	5.3	12.3	-3.5	3.2	-1.1	-0.6	2.0	2.9	1.5	2.6	2.6	3.3	0.1	1.5	2.1
Leg fat-free mass (left)	2.5	13.5	30.1	-0.7	-1.0	-2.2	-1.2	-5.2	-4.3	-1.1	-5.2	-5.5	-5.5	-2.7	-2.9	-4.2
Leg predicted mass (left)	2.5	13.4	30.3	-0.7	-1.0	-2.1	-1.2	-5.2	-4.3	-1.1	-5.2	-5.5	-5.5	-2.6	-2.9	-4.2
Trunk predicted mass	2.5	14.1	36.6	0.1	-0.1	-1.3	-1.1	-5.2	-4.6	-1.1	-5.3	-6.0	-6.1	-2.0	-2.8	-4.2
Ever depressed for a whole week	2.5	3.1	7.3	-0.2	1.4	0.3	1.2	1.6	2.1	2.0	2.4	0.7	1.5	1.9	2.7	2.6
Systolic Blood Pressure	2.4	12.0	30.6	-0.8	-1.9	-0.5	4.3	1.9	4.4	5.5	3.7	0.7	2.0	2.7	4.9	5.5
Bilateral oophorectomy (both ovaries removed)	2.4	2.8	6.6	0.3	-0.7	2.0	0.7	2.6	1.7	0.3	2.0	2.4	2.4	1.8	1.2	1.1
Arm fat percentage (right)	2.4	9.3	21.0	-0.0	-2.2	-0.6	-3.1	-3.4	-3.6	-2.5	-4.2	-3.0	-3.3	-2.4	-3.4	-4.6
Trunk fat-free mass	2.4	13.9	36.3	0.1	-0.1	-1.4	-1.0	-5.2	-4.5	-1.0	-5.3	-6.0	-6.0	-2.0	-2.7	-4.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	6.6	-0.6	0.1	1.1	0.8	2.5	1.8	0.3	2.3	2.4	2.6	1.6	1.7	1.7
Ulcerative Colitis (UC)	2.3	4.3	10.0	-1.0	2.5	1.0	0.4	2.7	2.2	0.0	2.9	3.2	3.1	1.0	1.1	2.3
Heel T-Score	2.3	18.1	37.3	1.9	5.4	5.0	1.9	6.1	3.2	-0.1	5.2	5.0	4.5	5.2	3.5	3.5
Hand grip strength (left)	2.3	6.0	27.9	2.3	-1.0	-0.7	0.8	-2.8	-2.0	1.6	-2.3	-5.3	-4.3	1.4	1.3	-0.9
Whole body fat mass	2.3	9.4	19.0	-0.4	-1.1	-1.2	-2.9	-3.8	-3.7	-2.0	-4.3	-3.9	-3.9	-2.2	-2.8	-4.4
Smoking Status	2.2	5.4	13.5	0.5	-2.3	1.2	3.3	1.9	1.5	2.3	2.4	-0.4	0.6	3.7	3.7	2.8
Angina (self-reported)	2.2	3.0	10.8	2.7	-0.0	2.2	1.9	1.1	0.5	1.3	0.9	-0.8	-0.3	3.3	2.4	1.2
Arm fat percentage (left)	2.2	8.6	19.3	-0.2	-2.2	-0.8	-3.0	-3.3	-3.4	-2.3	-4.0	-2.8	-3.1	-2.5	-3.3	-4.4
Schizophrenia (2014)	2.1	4.6	9.9	-0.0	2.7	0.1	-1.5	-1.8	-2.7	-2.7	-2.6	-0.8	-2.2	-2.0	-3.1	-2.6
Angina	2.1	2.7	10.1	2.6	0.2	2.0	1.8	1.1	0.5	1.2	1.0	-0.8	-0.2	3.2	2.4	1.1
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	8.0	-1.2	1.8	0.8	-0.1	2.4	1.6	0.4	2.8	1.4	2.2	2.2	2.2	2.0
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	7.2	0.9	2.7	2.2	0.5	2.2	1.0	-0.4	1.9	1.9	1.8	1.7	0.8	1.4
Neck or shoulder pain in last month	2.1	3.0	5.4	0.5	2.2	1.8	1.8	2.1	1.3	0.8	2.0	1.3	1.6	2.3	2.0	1.8
Leg fat percentage (left)	2.1	7.6	17.0	0.3	-1.4	-0.1	-3.2	-3.0	-3.5	-2.1	-3.6	-3.6	-3.5	-0.9	-2.1	-4.1
Pain experienced in last month	2.1	3.6	9.7	-1.4	-1.8	-3.1	-2.5	-2.5	-0.7	-0.1	-1.7	-1.6	-1.2	-2.7	-1.4	-1.6
Mouth/teeth dental problems	2.0	3.1	7.3	-0.7	-1.1	-0.4	-2.2	-1.7	-1.7	-1.8	-2.2	-0.4	-1.4	-2.3	-2.7	-2.3
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	6.3	1.5	-0.8	1.0	0.7	2.1	0.7	-0.1	2.2	0.8	1.5	2.5	2.1	1.5
Ever highly irritable/argumentative for 2 days	2.0	2.4	3.6	-0.4	0.2	1.6	1.7	1.7	1.9	1.6	1.8	1.4	1.7	1.7	1.6	1.7
Blood Red Count	1.9	18.7	41.5	3.9	3.2	5.5	3.4	6.4	2.4	-0.9	5.2	5.4	4.0	5.6	3.2	4.0
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	9.8	-1.3	0.7	-1.5	-3.1	-1.8	-0.4	-0.1	-1.2	-1.3	-0.7	-1.7	-1.0	-1.6
Pack years adult smoking proportion	1.9	2.9	7.5	0.6	-2.0	1.8	2.7	1.7	1.1	1.5	1.3	0.6	0.5	2.7	2.1	1.6
Pain all over the body in last month	1.9	2.1	4.7	-0.4	0.0	1.6	0.4	1.7	2.0	0.9	1.9	1.8	2.2	1.1	1.1	1.5
Leg fat percentage (right)	1.9	7.0	14.9	0.2	-1.7	-0.4	-2.8	-2.9	-3.4	-2.1	-3.5	-3.4	-3.4	-1.0	-2.1	-3.9
Pulse wave peak to peak time	1.9	2.3	4.6	-2.1	-0.8	-1.0	0.2	1.6	1.7	0.8	2.0	1.6	1.8	1.1	1.9	1.5
Average weekly champagne plus white wine intake	1.9	2.6	6.5	-0.0	2.5	1.9	-1.7	1.6	-0.1	-2.4	0.9	2.5	1.8	0.1	-1.2	-0.7
Medication for hormone replacement therapy	1.8	2.0	4.5	0.1	-0.8	-0.2	1.7	1.2	1.8	2.0	1.7	0.7	1.3	0.9	1.9	2.1
Exposure to tobacco smoke outside home	1.8	2.3	8.8	-0.5	-1.5	1.5	0.6	1.7	0.9	0.8	1.9	0.0	0.8	3.0	2.4	1.5
Mouth/teeth dental problems: Loose teeth	1.8	2.1	4.9	-0.7	0.0	0.0	0.5	1.4	1.8	1.5	2.2	0.6	1.7	1.5	2.2	2.1
Osteoarthritis (self-reported)	1.8	2.3	5.1	0.2	1.8	1.7	-0.9	2.3	0.9	-0.9	2.1	2.1	2.2	1.4	0.8	0.7
Pack years of smoking	1.8	2.6	6.1	0.7	-1.7	2.0	2.5	1.9	1.1	1.1	1.4	1.2	0.9	2.4	1.7	1.5
Average weekly spirits intake	1.7	2.1	4.4	0.9	-1.3	0.4	1.3	2.1	0.9	0.3	2.1	0.8	1.2	2.1	2.0	1.8
Diabetes (mother)	1.7	2.2	13.1	1.3	-3.6	1.8	0.5	-0.9	-0.5	1.0	-1.0	-1.8	-1.4	1.0	0.2	-0.8
Hip circumference	1.7	7.3	12.5	-1.9	-1.2	-2.3	-2.5	-3.5	-2.9	-1.2	-3.5	-3.5	-3.3	-2.2	-2.0	-3.3
Pulse wave Arterial Stiffness index	1.7	2.0	3.8	1.9	1.1	0.7	0.1	-1.7	-1.5	-0.5	-1.9	-1.6	-1.8	-1.1	-1.7	-1.3
Commuting to job workplace: Car/motor vehicle	1.7	1.9	6.8	1.3	-0.3	0.4	0.6	1.5	1.6	0.1	1.6	2.6	2.6	-0.6	-0.0	1.3
Medication: Gliclazide	1.7	1.9	5.9	-1.1	-1.3	-1.4	-1.4	-2.0	-0.4	0.2	-1.7	-0.8	-0.9	-2.4	-1.6	-1.3
Schizophrenia (2018)	1.6	3.3	7.8	-0.5	1.8	0.2	-1.3	-1.7	-2.2	-2.0	-2.4	-0.9	-1.9	-1.8	-2.8	-2.2
Alzheimer’s Disease (in mother)	1.6	1.8	5.5	-0.9	1.2	0.4	-0.6	1.9	1.3	-0.6	1.9	2.4	2.2	0.4	0.4	1.1
Age at First Birth	1.6	2.3	5.8	-0.5	1.3	-0.8	-0.9	-1.3	-2.4	-2.0	-1.6	-2.2	-1.9	-0.4	-1.2	-1.6
Ulcerative Colitis	1.6	2.2	5.9	-0.7	2.4	0.6	2.0	1.9	1.2	-0.1	1.6	2.3	1.7	0.8	0.7	1.3
Ever had hysterectomy (womb removed)	1.6	1.8	4.7	-1.7	-0.6	-0.8	0.5	1.1	2.0	1.2	1.6	1.6	2.2	-0.0	1.1	1.4
Serious illness, injury or assault to yourself	1.6	2.0	4.1	0.0	1.9	1.2	1.4	1.3	1.4	1.3	1.5	0.6	0.8	2.0	1.9	1.6
Multivitamins +/- minerals	1.6	2.1	7.1	-0.5	1.1	1.2	-1.1	0.2	-0.5	-2.1	-0.5	1.9	1.2	-1.9	-2.7	-1.4
Number of incorrect matches in round	1.6	2.7	9.0	-2.2	-0.1	-1.5	-3.0	-1.7	-0.9	-0.8	-1.4	-1.0	-0.6	-2.1	-1.7	-2.0
Medication: Lansoprazole	1.6	1.9	3.4	1.1	0.5	1.5	1.9	1.7	1.1	0.9	1.4	0.9	1.2	1.8	1.5	1.5
Tense / ‘highly strung’	1.6	2.7	8.7	-2.1	3.0	-0.1	-1.3	1.9	1.3	-0.4	1.9	2.0	2.3	0.8	1.0	0.9
Headache pain in last month	1.6	2.7	8.0	1.3	1.8	1.9	2.3	2.1	0.9	-0.6	1.6	2.8	1.9	0.3	-0.5	1.5
Heart attack/myocardial infarction (self-reported)	1.6	2.0	8.4	2.4	1.3	2.9	0.6	0.6	-1.3	-1.3	-0.3	-0.7	-1.1	2.1	0.1	-0.4
Alcohol drinker status: Previous	1.6	1.9	3.8	-0.3	1.1	0.9	0.9	2.0	1.4	0.6	1.7	1.9	1.6	1.5	1.4	1.4
Bipolar Disorder or Schizophrenia	1.5	3.6	17.8	-0.5	4.2	-0.6	-0.5	-1.4	-1.9	-1.8	-2.1	-0.3	-1.7	-1.8	-2.5	-1.7
HbA1C	1.5	1.7	5.4	0.3	0.1	1.1	-2.1	-0.7	-0.8	-1.5	-1.3	0.3	-0.3	-1.4	-2.3	-1.9
LDL Cholesterol	1.5	2.4	7.8	-0.4	-1.7	0.3	-2.8	-0.7	-1.6	-2.5	-1.0	-0.0	-0.6	-1.3	-2.0	-2.1
Blood Eosinophil Count	1.5	11.5	24.3	-2.8	2.4	-0.7	-4.9	-2.7	-4.5	-4.7	-3.2	-2.6	-3.0	-1.9	-3.5	-4.5
Nervous feelings	1.5	2.8	6.2	-1.4	2.4	-0.1	-1.0	2.1	1.6	-0.1	2.4	2.2	2.5	0.9	1.2	1.5
Exposure to tobacco smoke at home	1.5	1.6	5.6	-1.0	-0.1	-0.7	0.7	0.2	1.5	2.4	1.2	-0.8	0.5	1.1	2.2	1.8
Pulse wave reflection index	1.5	1.8	3.7	1.3	1.3	0.4	-0.1	-1.4	-1.5	-1.1	-1.9	-1.0	-1.3	-1.2	-1.9	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	4.7	-0.7	1.8	0.0	-0.2	1.4	1.9	0.8	1.9	1.8	2.2	0.2	1.0	1.7
Illnesses of father: Heart disease	1.5	2.0	5.8	2.4	1.4	2.4	0.3	0.2	-1.8	-1.9	-1.1	-0.0	-1.2	0.8	-1.2	-1.2
Average weekly red wine intake	1.5	2.3	7.7	-0.4	-1.7	-1.2	-2.8	-1.4	-1.7	-1.2	-1.1	-2.1	-1.7	-0.2	-0.3	-1.6
Ever smoked	1.5	2.7	5.9	1.1	-1.4	1.5	1.0	2.1	1.5	0.8	2.1	1.1	1.6	2.4	2.1	1.6
Allergy or Eczema	1.4	3.6	10.6	-3.3	2.6	-2.9	-2.2	-0.3	0.7	-0.5	0.4	1.7	1.8	-2.7	-0.9	-0.1
Heart attack	1.4	1.8	7.5	2.1	1.3	2.7	0.5	0.4	-1.5	-1.4	-0.4	-0.7	-1.2	1.8	-0.1	-0.5
Hair/balding pattern: Pattern 4	1.4	3.4	8.3	-1.2	-2.9	-2.3	-1.5	-2.3	-1.4	0.1	-1.7	-2.9	-2.1	-1.2	-0.4	-1.5
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.9	-0.3	-0.1	0.4	1.9	1.6	1.7	1.4	1.8	1.0	1.5	1.6	2.0	2.0
Medication: Blood pressure	1.4	2.7	9.8	0.3	-1.2	0.3	-0.5	-1.7	-2.1	-0.4	-2.0	-3.1	-2.8	0.8	-0.1	-1.8
Heart disease (siblings)	1.4	1.7	5.3	2.1	-0.7	0.9	2.3	0.2	0.1	1.4	0.0	-1.1	-1.1	1.9	1.5	0.9
Vitamin and mineral supplements	1.3	1.7	5.9	0.7	-2.4	-0.5	0.8	-0.3	-0.2	1.3	0.1	-1.9	-1.5	1.7	1.9	0.8
Trunk fat mass	1.3	5.6	12.6	-0.5	-0.3	-1.1	-2.7	-2.8	-2.8	-1.8	-3.2	-2.6	-2.6	-1.9	-2.3	-3.6
Back pain experienced in last month	1.3	1.9	4.8	-0.1	1.9	1.5	2.0	1.4	0.6	0.8	1.2	0.4	0.3	2.2	1.7	1.5
Bipolar Disorder (2018)	1.2	2.0	21.9	-0.1	4.7	-1.1	0.8	-0.1	-0.3	-0.4	-0.4	0.6	-0.3	-0.7	-0.5	0.0
Alzheimer’s Disease (including proxy)	1.2	1.7	5.4	-0.8	2.3	1.2	-1.2	1.5	0.5	-1.3	1.0	2.3	1.5	0.4	-0.3	0.1
Major Depression (MDD)	1.2	1.4	4.0	0.4	1.6	2.0	0.0	1.7	-0.0	-1.5	1.0	1.7	1.4	0.8	-0.3	0.0
Cardiovascular Disease	1.2	3.9	10.0	-2.0	-3.1	-1.7	-2.4	-2.4	-1.3	0.3	-1.8	-3.2	-2.3	-0.4	-0.0	-1.5
Systolic blood pressure, automated reading	1.2	3.4	12.5	-0.4	-2.4	-0.5	1.9	0.3	2.4	3.5	1.5	-0.3	0.8	1.1	2.5	2.5
Severe depression (siblings)	1.2	1.3	2.6	0.3	0.4	-0.4	-1.2	-1.1	-1.6	-1.4	-1.4	-1.2	-1.6	-0.6	-1.2	-1.3
Hand grip strength (right)	1.2	3.2	13.5	2.1	-0.4	-0.7	1.0	-1.7	-1.1	1.5	-1.4	-3.7	-3.1	1.4	1.4	-0.1
Maternal smoking around birth	1.2	1.7	6.9	1.6	-2.1	1.5	0.3	0.7	-0.8	-0.3	0.4	-1.1	-1.0	2.6	1.3	0.1
Relative age voice broke	1.2	1.8	5.2	0.6	1.0	2.0	1.0	1.9	0.9	0.4	1.4	1.1	1.1	2.3	1.5	1.1
Qualifications: CSEs or equivalent	1.2	1.5	10.0	0.3	-3.2	0.1	-0.5	0.9	1.1	0.1	1.3	1.3	1.8	-0.4	0.2	0.8
Had menopause	1.2	1.5	5.4	1.3	-1.7	0.5	0.4	0.2	-0.1	1.1	0.2	-1.7	-1.1	2.3	2.0	0.5
Medication: Simvastatin	1.2	1.8	7.3	0.6	-2.1	0.7	-0.2	-1.5	-0.4	1.4	-1.2	-2.7	-1.9	0.8	0.5	-0.6
Body fat percentage	1.2	4.7	11.6	-0.4	-0.9	-0.8	-2.9	-2.3	-2.5	-2.0	-2.8	-2.0	-2.1	-1.7	-2.2	-3.4
Heart disease (mother)	1.2	1.4	5.1	0.4	-2.3	-0.8	-0.1	-1.1	-0.7	0.9	-0.9	-2.2	-1.8	0.8	1.0	-0.2
Number of full sisters	1.2	1.4	6.1	0.6	-2.5	1.3	1.1	0.9	0.4	0.8	1.1	-0.1	0.2	1.9	1.5	1.0
Ever had bowel cancer screening	1.2	1.4	4.2	-0.3	1.8	0.9	-0.5	1.7	0.7	-0.8	1.4	2.1	1.8	0.5	0.2	0.5
Financial situation satisfaction	1.2	1.4	4.7	0.8	0.9	1.8	-1.3	0.5	-1.7	-2.2	-0.3	-0.5	-0.6	1.3	-0.5	-1.4
Neuroticism (Nagel 2018)	1.1	2.5	6.3	-2.4	2.5	-0.3	-1.0	1.5	1.7	0.1	1.7	2.2	2.5	-0.3	0.3	1.0
Crohns Disease (2017)	1.1	2.5	10.6	-1.3	3.3	-0.3	-1.3	-0.8	-0.6	-1.4	-1.1	0.8	0.4	-2.4	-2.4	-1.5
HDL Cholesterol	1.1	1.8	3.5	-0.7	0.0	-0.3	1.4	1.7	1.6	0.9	1.6	1.9	1.6	1.0	1.6	1.6
Lupus	1.1	1.6	3.0	1.4	-0.0	0.9	0.5	1.2	1.7	1.4	1.6	1.0	1.2	1.2	1.5	1.6
Rheumatoid Arthritis	1.1	1.6	6.5	-0.7	-2.5	-0.1	0.0	1.1	1.0	-0.4	1.3	2.1	2.0	-0.7	-0.3	0.8
Townsend deprivation index at recruitment	1.1	1.5	5.2	0.1	-1.0	-0.1	1.9	-1.2	-1.4	0.3	-1.2	-2.2	-2.3	0.5	0.2	-0.0
Age when periods started (menarche)	1.1	2.6	5.5	-1.5	2.1	0.8	0.5	2.2	1.2	-0.5	2.3	2.3	2.1	1.2	1.1	1.5
Hayfever, allergic rhinitis or eczema	1.1	2.4	8.4	-2.9	0.8	-2.8	-1.8	-0.5	0.5	-0.4	0.1	1.1	1.3	-2.6	-1.0	-0.3
Alcohol intake versus 10 years previously	1.1	1.7	3.3	0.8	0.8	0.9	1.8	1.5	1.4	0.8	1.5	1.6	1.7	0.7	0.9	1.7
Illnesses of mother	1.1	1.4	6.3	-0.0	2.5	0.9	1.1	1.4	0.7	0.1	1.2	1.4	0.9	1.0	0.6	1.1
Hypertension (Self-reported)	1.1	3.0	11.4	-1.1	-2.2	-0.6	-1.0	-2.0	-1.8	0.1	-1.9	-3.4	-2.7	0.7	0.3	-1.5
Illnesses of siblings: Diabetes	1.1	1.4	7.6	2.1	1.0	2.7	0.0	1.0	-0.0	-0.3	0.5	0.7	0.3	1.6	0.3	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	9.8	0.1	0.5	-3.1	-1.8	-1.9	-0.6	0.8	-0.9	-2.7	-1.8	-0.5	0.7	-0.2
Guilty feelings	1.1	1.6	4.2	-2.1	1.9	-2.1	0.9	-0.2	1.4	1.4	0.6	0.3	0.7	-1.1	0.4	1.3
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.5	1.4	0.9	2.1	-0.9	0.8	-0.4	-1.8	-0.0	1.6	1.1	-0.3	-1.5	-1.0
Irritable Bowel Disease (IBD)	1.0	2.4	13.6	-1.4	3.7	0.4	-0.8	1.0	0.9	-0.9	1.0	2.3	1.9	-0.9	-0.9	0.4
Prostate Cancer	1.0	1.5	7.5	-2.7	-1.9	-2.4	0.0	0.0	0.0	0.0	0.0	-1.3	0.0	0.0	0.0	0.0
Crohns Disease (2012)	1.0	1.7	9.8	-2.1	3.1	-0.6	-0.9	-0.4	0.3	-0.4	-0.3	0.9	0.8	-1.6	-1.2	-0.6
Hypothyroidism (self reported)	1.0	2.3	6.1	2.0	-1.6	2.5	-0.3	0.3	-2.0	-2.4	-0.9	-0.5	-0.9	1.3	-1.0	-1.6
Neuroticism	1.0	2.3	5.4	-1.9	2.3	-0.5	-0.2	1.6	1.7	0.4	1.8	1.9	2.3	0.2	0.9	1.3
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.4	-0.8	1.9	1.1	-0.2	1.4	0.6	0.3	1.5	0.1	0.6	2.1	1.7	1.0
Taking other prescription medications	1.0	1.5	4.5	-0.9	0.5	-0.0	0.4	1.1	1.8	1.0	1.7	1.5	2.1	0.1	0.9	1.5
High blood pressure	1.0	2.9	10.2	-1.4	-2.2	-0.9	-1.1	-2.0	-1.7	0.2	-1.8	-3.2	-2.5	0.4	0.3	-1.5
High blood pressure (mother)	1.0	1.5	7.5	0.2	-2.7	-1.0	-1.1	-1.4	-0.6	0.1	-1.3	-1.3	-0.9	-1.2	-0.7	-1.0
Medication: Paracetamol	1.0	1.6	4.4	-1.5	1.7	1.5	0.3	1.4	0.5	-1.0	1.2	2.1	1.8	-0.3	-0.8	0.7
Qualifications: College or University degree	1.0	3.1	6.7	-0.6	2.6	-1.5	-1.7	-1.6	-2.1	-1.9	-2.0	-1.4	-1.9	-1.3	-1.6	-1.9
Age at last live birth	1.0	1.5	4.1	-0.8	0.6	-2.0	-1.4	-1.4	-1.0	-0.6	-1.3	-1.3	-1.3	-1.1	-0.9	-1.3
Medication: Aspirin	1.0	1.4	2.7	1.6	0.3	1.6	1.4	0.8	1.1	1.5	0.9	0.1	0.6	1.5	1.3	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.2	-1.3	0.6	-0.2	1.0	0.8	1.4	1.2	1.3	0.6	1.1	0.8	1.4	1.5
Medication: Aspirin	1.0	1.3	2.9	1.7	-0.2	1.6	1.5	0.4	0.9	1.7	0.5	-0.4	0.0	1.5	1.3	1.1
Medication: Paracetamol	1.0	1.5	4.3	-1.6	1.5	0.6	0.4	1.1	0.8	-0.5	1.2	2.1	2.0	-0.8	-0.7	0.9
Average weekly beer plus cider intake	1.0	1.4	5.0	0.7	-2.2	-0.3	1.4	1.2	0.3	0.1	1.3	0.3	0.5	1.7	1.6	1.4
Risk taking	1.0	1.4	4.0	-1.2	-0.6	1.4	-1.3	0.2	-0.2	-1.4	-0.3	1.7	1.1	-1.2	-2.0	-1.2
Intelligence (Savage-Jansen 2018)	0.9	2.8	7.8	2.5	0.6	0.3	1.7	-0.4	-0.8	1.1	-0.6	-2.8	-2.5	2.5	2.0	0.5
Neuroticism (2016)	0.9	1.3	3.3	-0.5	1.4	0.0	-1.5	0.1	-0.4	-1.8	-0.4	1.2	0.9	-1.3	-1.8	-1.2
Sensitivity / hurt feelings	0.9	1.5	4.5	-0.3	-0.3	2.1	-0.3	1.9	0.3	-1.4	1.1	2.0	1.7	0.7	-0.4	0.2
Hearing difficulty/problems: Yes	0.9	1.3	3.9	1.3	0.1	2.0	-0.2	1.7	0.0	-1.1	1.4	1.1	1.1	1.5	0.5	0.4
Had other major operations	0.9	1.1	2.7	-1.2	-1.4	0.7	1.1	0.9	0.8	-0.0	1.2	1.6	1.5	0.0	0.0	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	5.8	-0.1	2.4	1.1	0.9	1.1	1.0	0.8	1.4	0.5	1.0	1.1	1.0	1.5
Pulse rate	0.9	1.5	3.3	0.5	1.8	0.2	-1.3	-1.1	-1.5	-1.3	-1.1	-1.1	-1.6	-0.6	-1.4	-1.1
Mouth/teeth dental problems: Dentures	0.9	1.4	3.2	1.4	-0.9	1.0	1.8	0.6	1.1	1.8	1.0	-0.1	0.7	1.3	1.5	1.3
Birth weight	0.9	1.9	4.9	2.2	1.4	0.9	0.0	-0.6	-2.2	-1.8	-1.1	-1.3	-2.0	0.6	-0.7	-0.9
Migraine (self-reported)	0.9	1.1	3.6	1.2	1.7	0.5	0.5	1.2	0.4	-0.7	0.8	1.9	1.3	-0.2	-0.3	0.6
Medication: Allopurinol	0.9	1.1	4.6	1.0	0.5	2.1	-0.8	1.4	-0.2	-1.4	0.6	1.3	0.9	1.2	-0.1	-0.5
Family relationship satisfaction	0.9	1.1	2.6	0.4	1.4	0.4	0.2	-0.7	-1.6	-0.9	-1.4	-1.3	-1.6	0.1	-0.8	-1.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.7	-1.0	-0.5	-1.6	0.2	-1.5	0.3	1.6	-1.1	-1.3	-1.0	-1.1	0.0	-0.3
Medication for cholesterol	0.9	1.4	4.3	-0.7	2.1	-0.5	-0.8	-0.1	-0.1	-1.3	-0.2	1.5	0.8	-2.0	-1.9	-0.4
Ever taken oral contraceptive pill	0.9	1.0	4.2	-2.1	-0.2	-1.2	1.0	-0.0	1.0	1.4	0.8	-0.1	0.4	-0.2	0.8	1.3
Illnesses of father: High blood pressure	0.9	1.1	4.2	0.2	0.4	-1.2	0.9	-1.3	-0.5	1.0	-1.1	-2.0	-1.6	-0.1	0.4	0.2
Supplements: Calcium	0.9	1.0	5.2	-0.4	0.5	-0.4	-0.6	-1.0	-0.0	-0.4	-0.7	0.5	0.4	-2.3	-1.9	-0.6
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.7	-1.6	-0.4	-1.2	-0.2	-0.3	1.4	1.4	0.3	0.8	0.9	-1.4	-0.1	0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.8	0.5	-1.7	-0.1	0.9	0.0	0.7	1.7	0.5	-0.9	-0.2	1.1	1.6	0.9
Allergy	0.8	1.9	6.2	2.5	-0.9	2.0	1.3	0.2	-1.0	-0.1	-0.4	-1.3	-1.7	2.5	0.9	-0.1
Fluid intelligence score	0.8	1.6	6.8	2.6	1.1	0.5	0.0	-0.5	-1.5	-0.8	-0.8	-1.7	-1.9	1.2	0.3	-0.4
Father’s age at death	0.8	1.1	4.2	-1.1	0.2	-0.7	1.1	0.2	1.6	2.0	0.8	0.2	0.7	0.1	1.2	1.4
Leg pain on walking	0.8	1.1	3.8	-2.0	-0.9	-0.2	0.6	0.4	1.5	1.6	0.8	0.4	1.0	0.3	1.0	0.9
Osteoporosis (self-reported)	0.8	1.0	2.5	0.8	0.9	1.4	-0.8	-0.4	-1.1	-1.5	-0.8	0.0	-0.5	-0.5	-1.6	-1.2
Myopia	0.8	1.1	5.5	0.6	-0.4	0.2	-0.0	0.2	-0.7	0.2	0.1	-1.7	-1.4	2.3	1.8	0.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	8.7	0.3	1.9	-0.0	0.2	1.6	1.5	-0.3	1.6	3.0	2.5	-1.0	-0.5	1.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.3	-0.6	-0.9	0.8	-1.4	-0.7	-0.9	-1.1	-0.8	-0.2	-0.4	-0.9	-1.5	-1.2
Medication: Metformin	0.7	1.0	3.5	-0.9	-1.8	-0.7	-0.6	-1.2	0.2	0.5	-0.8	-0.3	-0.1	-1.9	-1.1	-0.6
Diabetes (father)	0.7	0.9	4.8	1.5	0.8	2.2	-0.4	0.5	-0.6	-0.8	-0.3	0.2	-0.2	1.0	-0.3	-0.9
Medication: Atenolol	0.7	0.9	6.2	2.5	-0.5	1.2	1.8	0.0	-0.2	0.1	-0.7	0.2	-0.4	0.2	-0.5	-0.2
Neuroticism score	0.7	1.5	3.8	-1.9	1.6	-0.6	-0.5	1.4	1.1	0.0	1.5	1.3	1.7	0.5	1.0	1.0
Happiness	0.7	0.9	2.4	-0.4	0.7	0.0	-0.8	-0.7	-1.6	-1.1	-0.9	-1.5	-1.4	0.2	-0.5	-1.0
Noisy workplace	0.7	0.8	3.2	-1.3	-0.9	0.1	1.7	-0.6	0.8	1.8	-0.3	-0.3	0.2	-0.6	-0.0	0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.9	-0.8	1.1	-1.2	-0.5	-1.6	-1.2	-0.5	-1.6	-1.4	-1.7	-1.1	-1.1	-1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.6	1.4	1.1	0.3	1.6	1.3	0.8	0.4	1.2	1.2	1.0	0.8	0.9	1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.9	2.0	-1.2	1.7	-0.4	-0.0	-1.6	-1.6	-0.7	-0.7	-0.8	0.7	-0.8	-1.2
High blood pressure (siblings)	0.7	1.0	2.3	-0.0	-0.7	-0.9	-0.6	-1.3	-1.0	-0.1	-1.5	-1.5	-1.4	-0.7	-0.6	-1.1
Health satisfaction	0.7	1.0	2.4	-0.7	1.4	1.2	-1.0	1.3	0.6	-0.6	1.1	1.0	1.6	0.6	0.2	0.2
Miserableness	0.7	1.2	2.3	-0.5	0.8	0.7	1.1	1.2	1.5	1.3	1.3	0.9	1.0	1.0	1.1	1.5
High cholesterol (Self-reported)	0.7	1.3	4.0	-1.4	-2.0	-0.5	-1.5	-1.5	-0.1	0.9	-0.8	-1.7	-0.9	-0.3	0.0	-0.7
Irritability	0.7	1.3	2.5	-1.2	1.6	-0.9	-1.3	-0.8	-1.2	-1.4	-1.0	-0.6	-0.5	-1.0	-1.2	-1.3
Depressed Affect (Nagel 2018)	0.6	1.2	3.3	-0.6	1.6	0.3	-0.5	1.4	1.2	-0.1	1.4	1.7	1.8	0.3	0.5	0.9
Trunk fat percentage	0.6	2.4	6.7	-0.5	-0.3	-0.8	-2.6	-1.4	-1.6	-1.7	-1.8	-0.9	-0.9	-1.5	-1.7	-2.6
Forced vital capacity (FVC)	0.6	2.3	7.5	0.4	2.7	-1.5	1.3	0.5	1.1	1.7	1.3	-0.5	0.2	1.3	2.3	2.1
Medication: Ramipril	0.6	0.7	3.4	0.1	0.7	1.7	0.1	0.3	-0.0	0.5	0.0	-0.8	-0.8	1.8	1.0	0.1
Illnesses of siblings	0.6	0.9	3.5	-1.9	0.8	-0.8	-0.8	0.3	0.4	-0.7	0.6	1.2	1.2	-1.1	-0.6	0.0
Breastfed as a baby	0.6	0.8	1.6	0.2	1.1	0.7	0.8	0.6	1.1	1.2	1.0	0.6	0.4	0.7	0.9	1.3
Birth weight of first child	0.6	1.0	4.1	-0.4	1.2	-2.0	-0.4	-1.3	-0.3	0.1	-0.8	-0.6	-0.3	-1.9	-0.9	-0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.8	-0.2	1.6	-1.3	-1.1	-0.9	0.1	0.2	-0.6	-0.3	0.1	-1.7	-0.8	-0.5
Forced vital capacity (FVC), Best measure	0.6	2.0	5.6	0.8	2.4	-1.4	1.2	0.6	1.1	1.6	1.3	-0.5	0.3	1.4	2.3	1.9
Comparative height size at age 10	0.6	3.0	8.3	0.0	2.9	0.3	1.0	2.1	1.7	0.3	2.2	2.5	2.7	0.5	0.9	1.7
Supplements: Vitamin C	0.6	0.8	3.8	-0.0	1.9	-0.1	0.2	0.8	0.3	-0.8	0.7	1.5	1.2	-0.4	-0.5	0.3
Mood swings	0.6	1.1	2.8	-1.7	1.4	0.2	-1.3	1.2	0.5	-0.9	1.1	1.3	1.6	0.2	0.1	0.1
Medication: Atorvastatin	0.6	0.8	3.4	-1.1	-1.8	-1.3	-1.0	-0.5	0.3	0.7	0.3	-0.9	0.1	-0.1	0.8	0.2
Depression (Nagel 2018)	0.5	0.7	2.9	-0.4	1.7	1.3	-0.5	1.0	0.1	-0.5	0.8	0.3	0.4	1.3	0.6	0.3
Schizophrenia vs Biploar Disorder	0.5	0.6	1.6	-0.0	-0.4	0.7	-1.3	-0.6	-0.7	-0.9	-0.6	-0.5	-0.3	-0.7	-1.2	-1.1
Bipolar Disorder (2011)	0.5	0.5	4.7	0.1	2.2	-0.6	0.7	-0.2	-0.5	-0.5	-0.4	-0.0	-0.5	-0.2	-0.5	-0.1
Coronary Artery Disease (CAD)	0.5	0.6	2.7	0.4	-1.6	1.0	0.8	0.7	-0.2	-0.4	0.5	0.7	0.1	1.1	0.5	0.3
Blood White Count	0.5	4.0	8.1	2.4	-0.9	1.3	-1.4	-1.9	-2.6	-1.4	-2.5	-2.6	-2.9	-0.2	-1.6	-2.4
Lung FVC	0.5	2.5	7.4	2.0	0.3	-1.1	1.7	0.0	0.3	1.8	0.6	-2.0	-1.4	2.2	2.7	1.7
Fed-up feelings	0.5	1.0	2.3	1.0	1.5	0.2	-0.3	-0.8	-1.4	-1.0	-1.0	-1.0	-1.1	-0.4	-1.0	-1.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.2	-0.8	-1.5	0.1	-0.1	-0.9	-0.7	-0.0	-0.7	-1.2	-1.1	-0.1	-0.4	-0.4
Medication: Levothyroxine sodium	0.5	0.9	3.7	0.7	-1.8	1.9	-0.2	0.2	-0.9	-0.7	-0.3	-0.8	-0.7	1.2	0.0	-0.6
Past tobacco smoking	0.5	1.0	3.5	0.5	1.9	0.4	-0.7	-0.7	-1.3	-1.0	-1.1	-0.7	-1.2	-0.3	-1.0	-1.2
Alcohol usually taken with meals	0.5	0.8	2.8	-1.2	0.7	-0.9	-1.7	-0.2	0.5	-0.2	-0.0	1.0	1.0	-1.5	-0.8	-0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	0.3	0.8	0.8	0.7	0.7	0.7	0.8	1.0	0.1	0.3	1.2	1.1	1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.4	-0.8	-0.9	-1.0	-1.5	-0.3	0.3	-0.3	0.2	0.6	0.7	-1.4	-0.7	-0.0
Worrier / anxious feelings	0.5	1.0	4.4	-2.1	1.2	-0.4	-0.3	0.5	1.3	0.8	0.7	1.0	1.3	-0.6	0.1	0.7
Hair/balding pattern: Pattern 3	0.5	0.8	3.0	-1.5	1.7	-0.8	0.4	0.5	0.5	-0.3	0.5	1.4	1.0	-0.7	-0.3	0.5
Medication: Cholesterol lowering	0.5	0.8	2.9	-0.4	-1.3	-0.2	-1.0	-1.3	-0.5	0.4	-1.0	-1.7	-1.2	-0.2	-0.2	-0.7
Standing height	0.5	5.0	27.8	-0.7	5.3	-0.1	2.0	2.0	1.9	0.8	2.3	2.3	2.2	0.8	1.5	2.3
Peak expiratory flow (PEF)	0.5	1.1	4.6	0.0	-0.2	-2.1	-0.6	-1.1	-0.8	-0.7	-0.8	-0.3	-0.6	-1.9	-1.2	-0.4
Loud music exposure frequency	0.5	0.6	1.5	-0.7	0.5	-0.4	0.4	0.8	0.8	0.7	1.0	0.3	1.0	0.6	1.2	0.8
Eye problems/disorders: None of the above	0.5	0.6	1.7	-0.1	-1.0	0.6	-0.5	0.8	-0.1	-1.2	0.5	1.3	1.3	-0.2	-0.6	-0.6
Emphysema/chronic bronchitis	0.5	0.6	1.6	-0.6	-0.0	0.5	0.5	0.7	1.1	0.5	1.1	1.2	1.3	-0.2	0.1	0.7
Medication: Blood pressure	0.5	0.9	2.0	-1.2	-0.8	-0.4	-1.4	-1.3	-0.7	-0.1	-1.1	-1.4	-1.1	-0.5	-0.5	-1.1
Medication: Seretide 50 evohaler	0.5	0.5	2.4	-0.5	0.0	0.1	-0.1	0.9	0.5	-0.5	0.7	1.6	1.5	-0.6	-0.4	0.2
Mean time to correctly identify matches	0.5	1.0	6.8	-1.8	-2.6	-0.7	0.1	0.0	0.8	0.7	0.2	0.3	0.8	-0.5	0.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	0.9	-0.7	1.2	-1.2	-0.1	-0.7	-1.1	-0.3	-0.0	-0.1	-0.1	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	3.0	-1.6	1.7	-1.7	-0.6	-0.5	-0.2	-0.5	-0.4	0.2	-0.0	-1.4	-0.8	-0.2
Commuting to job workplace: Walk	0.5	0.5	1.4	-0.8	0.4	-0.6	0.9	-0.1	0.4	1.2	0.3	-0.8	-0.3	0.7	1.2	0.6
Eye problems/disorders: Cataract	0.5	0.6	3.5	0.1	1.9	-0.9	0.4	-0.7	0.6	0.9	-0.2	-0.1	-0.3	-0.9	-0.1	0.5
Mineral and other dietary supplements	0.5	0.6	2.0	-0.4	0.6	-1.3	0.1	-0.6	-0.6	0.2	-0.3	-1.4	-1.4	0.5	0.9	0.1
Wears glasses or contact lenses	0.5	0.6	3.8	1.2	2.0	0.5	1.1	-0.2	-0.2	-0.0	-0.4	-0.1	-0.4	-0.3	-0.6	-0.2
Hearing aid user	0.5	0.6	2.8	-0.5	-0.2	-0.8	-0.6	-1.1	0.2	0.6	-0.8	-0.4	-0.2	-1.7	-0.9	-0.5
Commuting to job workplace: Public transport	0.5	0.6	1.9	-0.6	-0.9	0.2	0.3	-0.1	-0.5	0.2	-0.1	-1.2	-1.3	1.4	0.9	0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.9	0.3	1.4	1.7	-0.3	1.0	0.0	-0.6	0.6	0.7	0.6	0.9	0.1	-0.0
Medication: Bendroflumethiazide	0.5	0.7	2.3	-1.1	-0.5	-0.5	-0.4	-1.1	-0.6	0.2	-1.0	-1.5	-1.3	0.0	0.0	-0.7
Unable to work because of sickness or disability	0.5	0.6	2.0	-1.4	-0.8	-0.2	1.0	0.5	0.7	0.6	0.8	0.7	0.7	0.2	0.6	0.9
Cholesterol lowering medication	0.5	0.8	2.4	0.6	-1.5	0.8	-0.4	0.0	0.1	0.7	0.2	-1.3	-0.4	1.5	1.3	0.0
Basal cell carcinoma (self-reported)	0.5	0.6	2.8	0.6	0.8	-0.8	0.2	-0.8	-0.7	0.3	-0.4	-1.7	-1.3	0.2	0.5	0.1
Reaction Time	0.4	0.7	2.8	-1.7	-1.3	-1.3	-0.8	-0.2	0.6	0.2	0.0	0.4	0.9	-1.0	-0.1	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.5	1.9	1.2	-0.2	1.3	-0.4	-0.8	-0.1	-0.6	-1.4	-1.4	0.7	0.4	0.1
Ovarian Cancer	0.4	0.5	1.5	-0.2	0.8	-0.4	1.0	0.2	1.0	1.2	0.4	0.6	0.4	0.0	0.6	0.8
Fasting Glucose	0.4	0.4	1.2	0.6	-1.0	1.1	-0.7	0.4	0.7	0.7	0.5	-0.1	0.4	0.8	0.7	0.1
Height	0.4	7.3	41.2	1.6	6.4	0.9	2.4	3.0	1.5	0.0	2.6	2.7	2.4	2.1	2.0	2.2
Medication: Co-codamol	0.4	0.5	2.2	0.3	1.5	-0.2	0.2	-0.5	-0.2	0.7	-0.3	-0.9	-1.1	0.9	0.8	0.1
Hair/balding pattern: Pattern 2	0.4	0.5	2.4	1.0	-0.1	1.5	0.1	0.1	-0.4	0.3	-0.1	-1.0	-0.8	1.2	0.5	0.1
Qualifications: None of the above	0.4	0.8	3.5	-0.8	-1.9	0.2	0.9	-0.7	0.9	1.5	-0.2	0.1	0.5	-1.1	-0.4	0.1
Diabetes (self-reported)	0.4	0.5	2.2	-0.3	-1.5	0.5	-0.3	-0.8	0.2	0.3	-0.6	0.0	-0.0	-1.3	-1.2	-0.5
Lung cancer (father)	0.4	0.5	2.1	0.3	0.9	1.4	0.7	0.1	-0.4	0.2	-0.0	-0.7	-0.7	1.1	0.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	6.5	0.9	2.5	-2.2	-0.1	-0.7	-0.2	0.6	-0.2	-1.1	-0.9	-0.2	0.7	0.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.2	1.1	0.8	0.4	0.4	0.3	-0.9	-1.5	-0.2	0.5	0.1	0.1	-0.8	-0.6
Wheeze or whistling in the chest in last year	0.4	0.8	4.2	-2.0	0.4	-1.0	-0.1	-0.2	0.7	0.4	0.6	0.4	1.1	-1.4	-0.5	0.5
Overall health rating	0.4	0.8	5.5	0.5	0.9	2.3	0.1	0.9	0.4	-0.0	0.8	0.5	0.6	1.1	0.4	0.5
Chest pain or discomfort	0.4	0.6	1.7	0.5	0.3	0.9	1.3	0.7	0.4	0.6	0.7	-0.1	0.1	1.3	1.1	1.0
Diabetes diagnosed by doctor	0.4	0.6	2.6	-1.0	-1.3	-0.2	-0.6	-0.7	0.7	0.5	-0.2	0.5	0.5	-1.6	-1.0	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.8	0.6	-0.4	0.6	0.3	0.2	-1.3	-1.3	-0.4	-0.4	-0.7	0.8	-0.2	-0.7
Illnesses of father: None of the above (group 1)	0.4	0.5	2.0	-1.0	-1.2	-1.4	-0.4	-0.5	0.2	0.6	0.2	-0.6	-0.1	-0.4	0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.5	-1.6	-1.3	-0.2	0.6	-0.4	0.3	0.6	-0.0	-0.2	0.2	-0.8	-0.3	0.3
Alzheimer’s Disease (in father)	0.3	0.4	3.7	0.4	1.9	0.6	-0.7	0.1	0.0	-0.2	-0.1	0.3	-0.0	0.2	-0.1	-0.1
Mean Putamen Volume	0.3	0.4	2.9	0.1	1.7	-0.2	0.1	0.0	-0.3	-0.6	-0.2	0.4	0.0	-0.7	-0.9	-0.2
Primary Biliary Cirrhosis	0.3	0.4	1.4	0.5	0.2	0.9	0.1	0.6	0.4	-0.3	0.4	1.2	1.1	-0.4	-0.4	0.2
Triglycerides	0.3	0.4	0.9	-0.2	-0.5	0.9	0.2	0.7	0.5	0.2	0.9	0.3	0.9	0.9	0.8	0.5
Waist Hip Ratio (WHR)	0.3	1.4	7.6	1.9	-1.6	2.8	-0.4	1.1	0.1	-0.8	0.2	1.0	0.7	0.8	-0.5	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.2	-0.4	-1.5	0.4	-0.9	-0.2	0.5	0.0	-0.3	0.8	0.8	-1.3	-1.1	-0.5
Hair Pigment	0.3	9.5	22.0	1.9	-2.3	2.8	2.3	4.7	1.9	-0.4	4.1	3.8	3.7	3.7	2.7	3.0
Supplements: Zinc	0.3	0.3	1.3	-1.0	-0.0	-1.1	-0.3	-0.2	0.5	0.3	0.1	0.5	0.5	-1.0	-0.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.9	-0.6	0.8	1.0	0.7	0.4	-0.2	-0.1	0.4	-0.4	-0.5	1.4	0.6	0.5
Supplements: Glucosamine	0.3	0.4	1.9	1.2	-1.2	1.4	0.0	-0.0	-0.1	0.1	-0.4	-0.1	0.0	0.2	-0.4	-0.5
Chronic bronchitis/emphysema (father)	0.3	0.4	1.4	0.5	0.3	1.0	-1.2	-0.1	-0.3	-0.6	-0.3	-0.2	0.5	-0.1	-0.6	-1.1
Financial difficulties in last 2 years	0.3	0.5	1.2	-0.4	-1.0	-1.1	-1.1	-0.2	-0.3	0.0	0.2	-1.0	-0.4	0.6	0.9	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	5.6	0.3	2.0	-2.4	0.4	-0.5	0.3	1.1	0.2	-0.9	-0.6	-0.0	1.1	1.1
Prospective memory result	0.3	0.3	1.0	-0.6	0.4	1.0	-1.0	0.5	0.4	-0.2	0.3	0.8	0.6	0.2	-0.2	-0.2
Gout (self-reported)	0.3	0.3	1.5	-0.1	-0.6	1.2	-0.8	0.6	0.2	-0.2	0.4	0.4	0.4	1.0	0.3	-0.2
Worry too long after embarrassment	0.3	0.5	1.7	-1.3	-0.7	-0.2	-1.0	0.6	0.2	-0.7	0.5	0.6	1.1	-0.2	-0.2	-0.3
Number of children fathered	0.3	0.3	1.3	0.8	-0.1	1.1	0.1	-0.5	-0.3	0.2	-0.6	-0.6	-0.7	0.3	-0.3	-0.4
Pulse rate, automated reading	0.3	1.0	3.4	-0.2	1.9	0.3	-1.6	-0.5	-1.1	-1.3	-0.5	-0.6	-0.8	-0.3	-1.0	-0.9
Smoking status: Previous	0.3	0.4	1.3	-0.5	-1.1	-1.1	-0.1	-0.2	0.8	0.7	0.2	0.3	0.7	-1.0	-0.0	0.4
Long-standing illness, disability or infirmity	0.3	0.4	1.3	-0.8	-0.5	1.1	-0.7	-0.8	-0.2	0.1	-0.6	-0.7	-0.5	-0.3	-0.7	-0.6
Asthma (self-reported)	0.3	0.5	1.6	-0.6	0.5	-1.2	-0.3	-0.9	0.4	1.1	-0.3	-0.9	0.0	-1.1	-0.2	-0.1
Mother’s age at death	0.3	0.3	1.1	0.1	-0.9	0.9	1.0	-0.2	0.3	0.9	-0.0	-0.6	-0.3	0.4	0.3	0.4
Medication: Lisinopril	0.3	0.4	1.4	-0.6	-0.8	-0.3	-0.0	-0.4	-0.6	0.1	-0.5	-1.2	-1.0	0.8	0.7	-0.3
Age started oral contraceptive pill	0.3	0.4	1.6	-0.7	-1.3	-0.1	0.2	-0.8	-0.3	0.1	-0.8	-0.6	-0.5	-0.6	-0.7	-0.6
Respiratory disease	0.2	0.5	2.1	-0.2	0.6	-0.3	-0.7	0.2	1.1	0.7	0.8	0.7	1.4	-0.7	0.2	0.5
Number of treatments/medications taken	0.2	0.4	2.0	-0.2	0.3	1.4	0.3	0.3	0.9	0.9	0.4	0.4	1.0	0.2	0.1	0.4
Average weekly fortified wine intake	0.2	0.2	0.6	-0.0	0.3	-0.0	-0.2	0.5	0.5	0.1	0.6	0.8	0.7	-0.2	-0.0	0.5
Sitting height	0.2	1.6	14.6	1.2	3.8	-0.0	1.4	0.0	0.1	0.7	-0.0	-0.5	-0.8	0.9	0.8	0.6
Hearing difficulty/problems with background noise	0.2	0.4	2.1	-1.5	-1.0	0.5	-1.0	0.1	0.3	-0.0	0.2	0.2	0.5	-0.2	-0.2	-0.5
Asthma	0.2	0.5	1.5	-0.7	0.5	-1.2	-0.2	-0.7	0.7	1.2	-0.1	-0.5	0.4	-1.1	-0.0	0.1
Depression (self-reported)	0.2	0.3	2.3	0.5	1.5	-0.1	0.1	0.3	0.4	0.4	0.4	0.1	0.3	0.3	0.5	0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.9	-0.5	0.2	-0.3	-0.6	0.3	0.1	0.1	0.5	-0.4	-0.0	0.9	1.0	0.3
Blood clot in the leg (DVT)	0.2	0.3	1.6	-1.3	-0.9	0.3	0.6	-0.3	0.2	0.3	0.0	0.0	0.3	-0.7	-0.5	0.2
Alcohol intake frequency.	0.2	0.5	1.4	-0.7	0.9	-0.2	-0.4	0.1	0.5	-0.2	-0.1	1.1	0.8	-1.2	-0.9	-0.2
Loneliness, isolation	0.2	0.3	1.0	0.4	0.4	-0.4	0.3	0.7	0.2	-0.0	0.8	0.1	0.2	1.0	1.0	0.8
Qualifications: nursing, teaching	0.2	0.4	1.4	1.2	0.3	0.1	0.3	-0.5	-0.6	-0.2	-0.7	-0.8	-1.0	-0.0	-0.3	-0.4
Number of self-reported non-cancer illnesses	0.2	0.3	1.9	0.2	0.1	1.4	0.4	0.5	0.5	0.4	0.4	0.3	0.5	0.7	0.2	0.2
Fractured/broken bones in last 5 years	0.2	0.3	1.2	0.0	-0.5	1.1	0.3	0.5	0.4	-0.0	0.6	1.0	0.5	0.0	-0.2	0.5
Blood Platelet Count	0.1	1.5	4.4	1.8	1.1	0.7	-0.7	0.6	-1.9	-2.1	-0.0	-0.5	-1.2	1.8	0.3	-0.6
Tanning	0.1	1.4	6.6	1.4	-0.1	2.6	1.0	1.5	-0.4	-1.5	0.5	1.3	0.4	1.5	-0.3	-0.3
Knee pain experienced in last month	0.1	0.2	0.8	0.3	0.0	0.9	0.5	0.5	-0.4	-0.6	-0.0	0.3	0.2	0.4	-0.2	-0.3

Hub : Genes

ADSL

Models

Trait associations