TWAS hub - MKL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0517	0.0238	0.0010	0.017	NA	0.031	NA	0.017	0.0077	NA	0.00042	NA	0.0069
2	TCGA	Colon Adenocarcinoma	0.0530	0.0340	0.0079	0.032	0.035	0.019	NA	0.021	0.0060	0.0039	0.02600	NA	0.0210
3	TCGA	Stomach Adenocarcinoma	0.0500	0.0270	0.0020	0.014	0.016	0.002	NA	0.008	0.0310	0.0220	0.23000	NA	0.0820

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Breast Cancer	45.3	109.0	146.4	7.6	-12.1	-11.1
Breast cancer (self-reported)	10.6	12.7	17.8	-3.5	4.2	2.9
Impedance of arm (left)	10.5	48.5	56.8	-6.6	7.5	6.8
Impedance of whole body	10.4	53.0	61.3	-6.4	7.8	7.5
Impedance of arm (right)	9.2	42.8	50.7	-5.6	7.1	6.8
Suffer from ‘nerves’	8.5	13.3	15.0	-3.3	3.9	3.7
Impedance of leg (left)	7.2	35.2	44.1	-4.8	6.2	6.6
Glaucoma (self-reported)	7.0	8.2	11.7	-2.0	3.0	3.4
Impedance of leg (right)	6.7	32.7	43.3	-4.4	6.0	6.6
Falls in the last year	6.4	8.6	10.5	-2.6	2.9	3.2
Comparative body size at age 10	5.9	16.4	28.6	1.7	-4.2	-5.3
Eye problems/disorders: Glaucoma	5.6	6.6	12.0	-0.7	2.7	3.5
Lung FEV1/FVC ratio	5.5	27.8	35.3	4.1	-5.6	-5.9
BMI	5.4	31.4	47.5	4.3	-5.4	-6.9
Ever had hysterectomy (womb removed)	5.3	6.0	8.3	-2.5	2.9	1.9
Diastolic blood pressure, automated reading	5.3	16.5	18.4	4.3	-4.1	-3.8
Body mass index (BMI)	5.1	21.5	29.9	3.4	-4.8	-5.5
Heel bone mineral density (BMD) T-score, automated (left)	4.8	10.8	18.7	-1.7	3.3	4.3
Heel bone mineral density (BMD) T-score, automated (right)	4.7	10.7	14.3	-2.1	3.7	3.8
Pulse wave peak to peak time	4.7	5.5	7.0	-2.2	2.1	2.7
Arm fat-free mass (left)	4.6	23.2	26.8	4.5	-5.2	-4.8
Worry (Nagel 2018)	4.5	9.5	12.5	-3.1	3.5	2.5
Arm predicted mass (left)	4.5	23.0	25.6	4.5	-5.1	-4.8
Shortness of breath walking on level ground	4.4	5.2	6.0	-2.2	2.5	2.2
Arm fat-free mass (right)	4.3	22.2	25.9	4.3	-5.1	-4.7
Arm predicted mass (right)	4.3	21.9	25.3	4.3	-5.0	-4.7
Mouth/teeth dental problems: Mouth ulcers	4.3	6.8	9.0	-2.0	2.7	3.0
Trunk predicted mass	3.9	22.0	25.5	4.5	-5.1	-4.5
Whole body water mass	3.9	22.5	26.0	4.3	-5.1	-4.8
Heart attack	3.8	4.8	10.3	3.2	-2.0	-0.4
Pulse wave Arterial Stiffness index	3.8	4.4	5.7	2.0	-1.9	-2.4
Birth weight	3.8	8.2	12.5	2.9	-3.5	-1.9
Whole body fat-free mass	3.8	21.9	25.7	4.2	-5.1	-4.8
Trunk fat-free mass	3.7	21.0	24.7	4.3	-5.0	-4.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.4	4.7	-2.1	2.0	2.2
Medication: Amlodipine	3.6	5.1	6.7	1.6	-2.4	-2.6
Heart attack/myocardial infarction (self-reported)	3.6	4.7	10.5	3.2	-1.9	-0.2
Bilateral oophorectomy (both ovaries removed)	3.5	4.1	5.5	-2.3	1.9	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	3.5	4.6	6.2	-1.7	2.5	2.1
Tinnitus: Yes, now most or all of the time	3.5	4.0	6.2	-1.6	1.8	2.5
Exposure to tobacco smoke at home	3.4	3.8	4.7	-2.2	1.9	1.8
Basal metabolic rate	3.4	19.0	22.4	3.6	-4.7	-4.6
Mouth/teeth dental problems: Loose teeth	3.3	3.9	6.2	-0.6	2.3	2.5
Frequency of tenseness / restlessness in last 2 weeks	3.2	5.0	5.7	-1.9	2.4	2.4
Arm fat mass (left)	3.1	12.9	19.7	2.3	-3.7	-4.4
Leg fat-free mass (left)	3.0	16.0	19.7	3.0	-4.4	-4.4
Leg predicted mass (left)	3.0	15.9	19.4	3.0	-4.4	-4.4
Waist circumference	3.0	10.8	17.9	2.0	-3.2	-4.2
Nervous feelings	3.0	5.6	8.4	-2.1	2.9	2.0
Tense / ‘highly strung’	3.0	5.0	6.5	-2.6	2.4	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	3.0	4.6	7.8	-0.8	2.3	2.8
Arm fat mass (right)	2.9	11.9	17.5	2.3	-3.6	-4.2
Leg fat-free mass (right)	2.9	15.4	19.3	2.9	-4.3	-4.4
Family relationship satisfaction	2.8	3.5	4.8	2.2	-2.0	-1.3
Leg predicted mass (right)	2.8	15.0	19.0	2.8	-4.3	-4.4
Schizophrenia (2014)	2.7	6.0	10.1	1.9	-2.0	-3.2
Number of full brothers	2.7	3.4	6.4	-0.6	1.9	2.5
Prostate Cancer	2.5	3.5	10.4	-3.2	0.0	0.0
Hypothyroidism (self reported)	2.5	5.7	9.1	3.0	-2.3	-1.6
Ever depressed for a whole week	2.5	3.1	5.4	-0.7	1.9	2.3
Heel T-Score	2.4	19.4	33.1	-1.5	4.8	5.8
Weight	2.4	11.8	15.8	2.4	-3.7	-4.0
Respiratory disease	2.3	5.1	7.9	-1.6	2.8	2.2
Serious illness, injury or assault to yourself	2.3	2.8	4.5	-1.1	1.7	2.1
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	5.0	1.6	0.7	2.2
Neuroticism score	2.3	4.8	6.6	-2.6	2.3	1.6
Pulse wave reflection index	2.3	2.8	4.5	1.2	-1.5	-2.1
Age at first live birth	2.3	4.2	7.5	0.6	-2.1	-2.7
Neuroticism (Nagel 2018)	2.2	5.3	7.6	-2.5	2.8	1.4
Angina	2.2	2.9	4.9	2.2	-0.2	1.9
Commuting to job workplace: Cycle	2.2	2.7	5.1	0.2	-1.7	-2.3
Hayfever, allergic rhinitis or eczema	2.1	4.6	12.4	-3.5	0.5	-1.0
Angina (self-reported)	2.1	2.8	4.5	2.1	-0.2	1.9
Leg fat mass (right)	2.1	8.0	11.9	1.7	-3.0	-3.4
Osteoporosis (self-reported)	2.1	2.6	3.8	0.6	-1.9	-2.0
Systolic Blood Pressure	2.0	9.9	18.8	-1.2	3.1	4.3
Medication: Atenolol	2.0	2.5	5.0	2.2	-1.3	-1.0
Handedness (chirality/laterality): Left-handed	2.0	2.4	3.2	1.1	-1.7	-1.8
Friendships satisfaction	2.0	2.5	4.7	1.3	-1.0	-2.2
Leg fat mass (left)	2.0	7.7	11.7	1.6	-3.0	-3.4
Alzheimer’s Disease (in mother)	1.9	2.2	5.0	-2.2	1.0	0.9
Bipolar Disorder (2011)	1.9	1.9	3.2	1.1	-1.8	-1.0
Neuroticism	1.9	4.6	6.8	-2.0	2.6	1.8
Illnesses of father: Heart disease	1.9	2.6	4.9	1.2	-2.2	-1.2
Miserableness	1.9	3.3	4.4	-2.1	1.9	1.4
Allergy or Eczema	1.8	4.7	12.9	-3.6	1.0	-0.5
Mouth/teeth dental problems	1.8	2.8	6.3	-0.7	-1.3	-2.5
Arm fat percentage (right)	1.8	7.1	12.0	1.5	-2.6	-3.5
Number of live births	1.8	2.5	5.8	-0.9	1.0	2.4
Pulse rate	1.8	3.1	3.7	1.4	-1.9	-1.9
Exposure to tobacco smoke outside home	1.8	2.4	4.6	-1.3	1.0	2.2
Illnesses of siblings: Diabetes	1.8	2.2	4.5	2.1	-1.2	-0.8
Mood swings	1.8	3.2	7.7	-2.8	1.4	0.3
Risk taking	1.8	2.7	4.3	-1.7	-1.0	-2.1
Schizophrenia (2018)	1.7	3.6	7.6	1.2	-1.4	-2.8
Type 2 Diabetes (T2D) (2012)	1.7	2.0	4.2	-2.1	1.3	-0.1
Time employed in main current job	1.7	2.0	4.3	-0.4	-1.3	-2.1
Guilty feelings	1.7	2.5	4.1	-2.0	1.6	1.0
High blood pressure (mother)	1.6	2.2	2.6	1.5	-1.6	-1.3
Ever highly irritable/argumentative for 2 days	1.6	1.9	2.3	-1.2	1.5	1.5
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	4.3	2.1	-1.9	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	2.6	-1.6	1.4	1.0
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.2	0.4	-1.5	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	4.9	0.1	1.0	2.2
Chronotype (morning person)	1.5	3.5	10.3	0.4	-0.3	-3.2
Relative age of first facial hair	1.5	3.1	6.4	-1.1	1.2	2.5
Father’s age at death	1.5	2.0	3.2	-0.5	1.8	1.6
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	3.4	-1.6	1.1	1.8
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.2	1.5	-1.4	-1.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	2.8	-0.6	1.7	1.4
Supplements: Vitamin C	1.5	1.8	3.5	-0.1	1.9	1.3
Arm fat percentage (left)	1.5	6.1	11.5	1.0	-2.4	-3.4
Schizophrenia vs Biploar Disorder	1.4	1.8	3.5	1.9	-0.6	-1.2
Medication for hormone replacement therapy	1.4	1.6	1.8	-1.3	1.3	1.1
Severe depression (siblings)	1.4	1.5	2.2	0.6	-1.5	-1.4
Hearing difficulty/problems with background noise	1.4	2.2	3.6	-1.4	1.9	1.0
Allergy	1.4	3.3	8.4	2.9	-1.2	0.4
Worrier / anxious feelings	1.4	2.6	4.1	-2.0	1.7	0.9
Peak expiratory flow (PEF)	1.4	3.2	3.9	1.6	-2.0	-1.8
Loud music exposure frequency	1.4	1.5	2.2	-0.2	1.5	1.5
Emphysema/chronic bronchitis	1.4	1.6	3.8	-0.3	2.0	0.9
Leg pain on walking	1.4	1.8	3.4	-1.1	1.8	0.9
Stomach or abdominal pain in last month	1.3	1.6	3.1	1.8	0.3	1.3
Diabetes (self-reported)	1.3	2.1	3.2	1.8	-1.1	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.3	-0.7	0.9	1.8
Qualifications: nursing, teaching	1.3	2.1	4.7	0.8	-2.2	-0.9
Osteoarthritis (self-reported)	1.3	1.7	2.1	1.1	1.3	1.5
Medication: Gliclazide	1.3	1.5	2.5	0.3	-1.4	-1.6
Bipolar Disorder or Schizophrenia	1.2	3.0	5.2	1.5	-1.3	-2.3
HbA1C	1.2	1.3	2.5	1.0	-0.7	-1.6
Medication: Ibuprofen	1.2	1.4	2.1	-0.7	1.4	1.3
Whole body fat mass	1.2	5.2	9.0	1.0	-2.3	-3.0
Medication: Aspirin	1.2	1.5	2.8	1.3	0.5	1.7
Ever taken oral contraceptive pill	1.2	1.4	3.9	-2.0	0.4	0.2
Hearing aid user	1.2	1.4	3.4	-1.8	0.9	-0.1
Average weekly fortified wine intake	1.1	1.3	1.9	-0.8	1.4	1.2
Qualifications: CSEs or equivalent	1.1	1.4	2.5	-1.1	1.6	0.7
Pain all over the body in last month	1.1	1.1	1.9	-0.4	1.4	1.2
Breastfed as a baby	1.1	1.3	2.0	-0.7	1.2	1.4
Medication: Omeprazole	1.1	1.4	3.5	0.2	0.7	1.9
Medication: Aspirin	1.1	1.4	2.6	1.2	0.5	1.6
Ulcerative Colitis (UC)	1.0	1.9	3.0	-1.1	1.2	1.7
Reaction Time	1.0	1.9	4.9	-2.2	0.8	0.2
Body Mass Index (BMI) (2010)	1.0	1.4	2.6	1.1	-0.6	-1.6
LDL Cholesterol	1.0	1.6	3.5	-0.3	-1.1	-1.9
Lupus	1.0	1.6	2.8	0.8	1.2	1.7
Fed-up feelings	1.0	1.8	2.5	0.6	-1.6	-1.5
Fluid intelligence score	1.0	2.1	4.6	2.1	-0.6	1.1
Illnesses of siblings	1.0	1.4	3.0	-1.7	1.1	0.2
Medication: Lansoprazole	1.0	1.1	1.7	1.0	0.8	1.3
Leg fat percentage (right)	1.0	3.7	5.5	1.2	-2.0	-2.4
Leg fat percentage (left)	1.0	3.5	5.5	1.1	-1.9	-2.3
Blood White Count	0.9	6.4	7.9	2.8	-2.5	-2.3
Age when periods started (menarche)	0.9	2.1	2.8	-1.5	1.1	1.7
Wheeze or whistling in the chest in last year	0.9	1.6	3.5	-1.9	1.2	-0.2
Heart disease (mother)	0.9	1.1	2.4	0.8	-1.5	-0.5
Pulse rate, automated reading	0.9	2.8	3.1	1.5	-1.7	-1.8
Ever smoked	0.9	1.6	3.9	-0.3	1.0	2.0
Age started oral contraceptive pill	0.9	1.1	1.8	-0.1	-1.3	-1.3
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.0	1.7	0.4	1.6
Fasting Glucose	0.8	0.9	1.7	0.2	1.3	1.1
Hand grip strength (left)	0.8	2.2	3.4	1.8	-1.8	-0.1
Average weekly spirits intake	0.8	0.9	2.1	0.9	0.1	1.4
Hearing difficulty/problems: Yes	0.8	1.3	2.2	-0.6	1.1	1.5
Diabetes (mother)	0.8	1.0	2.0	1.4	-1.0	-0.4
Taking other prescription medications	0.8	1.3	1.6	-1.1	1.3	0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.7	0.3	-1.3	-0.9
Number of incorrect matches in round	0.8	1.4	2.7	-1.6	-0.2	-1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.1	-1.5	-0.6	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.6	0.2	0.1	1.6
Medication: Cholesterol lowering	0.8	1.2	1.5	1.1	-1.2	-0.9
Illnesses of mother	0.8	1.0	1.3	-0.9	1.1	1.0
High blood pressure (siblings)	0.8	1.2	1.8	1.3	-1.1	-0.7
Worry too long after embarrassment	0.8	1.4	2.1	-1.3	1.4	0.6
Neck or shoulder pain in last month	0.8	1.2	2.3	0.1	1.1	1.5
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.5	1.5	-0.3	2.1
Crohns Disease (2012)	0.7	1.1	2.2	-0.8	1.5	0.5
Ulcerative Colitis	0.7	1.1	1.8	0.7	0.9	1.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.6	-0.7	0.9	1.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.2	0.2	-0.7	-1.5
Vitamin and mineral supplements	0.7	0.9	2.7	0.1	-1.6	-0.1
Relative age voice broke	0.7	1.0	1.8	-0.6	1.0	1.3
Hip circumference	0.7	2.8	6.2	0.1	-1.5	-2.5
Length of working week for main job	0.7	0.8	1.5	-0.9	0.2	-1.2
Mean time to correctly identify matches	0.7	1.4	3.9	-2.0	0.6	-0.1
Had major operations	0.7	0.9	1.4	1.2	0.1	1.1
Medication: Blood pressure	0.7	1.3	1.6	1.3	-1.0	-1.2
Depressed Affect (Nagel 2018)	0.6	1.3	2.3	-1.1	1.5	0.8
Alzheimer’s Disease (including proxy)	0.6	0.9	1.6	-1.3	1.0	0.5
Age at First Birth	0.6	0.8	1.5	0.6	-1.2	-0.7
HDL Cholesterol	0.6	1.0	1.3	-1.0	0.7	1.2
Sensitivity / hurt feelings	0.6	1.0	1.8	-0.9	1.3	0.6
Medication: Levothyroxine sodium	0.6	1.0	2.5	1.6	-0.6	-0.3
Forced vital capacity (FVC)	0.6	2.2	5.7	0.2	1.0	2.4
Hair/balding pattern: Pattern 3	0.6	0.8	2.1	-1.5	0.6	0.2
Noisy workplace	0.6	0.7	1.1	-1.0	1.1	0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	2.3	1.5	0.1	0.9
Asthma	0.6	1.2	1.7	-1.0	1.3	0.9
Prospective memory result	0.6	0.7	1.6	-1.3	0.6	0.3
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.3	-0.6	1.1	1.1
Qualifications: College or University degree	0.6	1.8	3.2	1.1	-1.8	-1.0
Age at last live birth	0.6	0.9	1.7	-0.5	-1.3	-0.9
Coronary Artery Disease (CAD)	0.5	0.6	1.3	-0.2	0.6	1.1
Blood Platelet Count	0.5	5.3	11.7	0.9	-3.4	-1.9
Blood Red Count	0.5	4.8	12.2	0.5	1.4	3.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.4	1.2	-0.7	-0.8
Systolic blood pressure, automated reading	0.5	1.5	2.8	-0.3	1.3	1.7
Hand grip strength (right)	0.5	1.4	2.1	1.5	-1.4	0.2
Current tobacco smoking	0.5	0.9	2.6	0.2	-0.1	1.6
Trunk fat mass	0.5	2.2	4.3	0.4	-1.5	-2.1
Alcohol usually taken with meals	0.5	0.7	1.7	-1.3	0.7	-0.1
Hair/balding pattern: Pattern 2	0.5	0.7	1.7	1.3	-0.5	0.1
Medication: Ramipril	0.5	0.6	1.1	0.4	0.7	1.1
Alcohol intake versus 10 years previously	0.5	0.8	1.3	-0.2	1.0	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	-0.2	0.8	1.0
Birth weight of first child	0.5	1.0	1.5	-0.1	-1.2	-1.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	0.8	-0.8	0.6	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.2	-0.5	1.1	0.6
Forced vital capacity (FVC), Best measure	0.5	1.7	4.6	-0.0	0.8	2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.9	-0.9	0.9	0.0
Comparative height size at age 10	0.5	2.8	3.9	-1.4	2.0	1.6
Back pain experienced in last month	0.5	0.8	1.5	-0.1	0.9	1.2
Asthma (self-reported)	0.5	1.1	1.7	-0.9	1.3	0.9
Wears glasses or contact lenses	0.5	0.6	0.7	0.5	-0.8	-0.8
Financial situation satisfaction	0.5	0.6	1.0	-0.0	-1.0	-0.9
Commuting to job workplace: Public transport	0.5	0.6	0.8	-0.9	-0.8	0.3
Myopia	0.5	0.7	1.1	0.8	-0.6	1.0
Mean Putamen Volume	0.4	0.4	0.7	0.5	-0.6	-0.8
Blood Eosinophil Count	0.4	3.4	5.7	0.7	-2.4	-2.0
Lung FVC	0.4	2.1	3.6	1.9	-0.7	1.4
Medication: Co-codamol	0.4	0.4	1.0	1.0	-0.5	0.1
Multivitamins +/- minerals	0.4	0.6	1.5	0.3	0.3	-1.2
Happiness	0.4	0.5	0.7	0.7	-0.7	-0.8
Depression (self-reported)	0.4	0.5	0.5	0.7	0.7	0.6
Standing height	0.4	3.9	6.0	-1.7	1.7	2.4
Gout (self-reported)	0.4	0.5	1.2	-1.1	0.5	0.2
Body fat percentage	0.4	1.5	3.5	-0.0	-1.0	-1.9
Overall health rating	0.4	0.9	1.6	1.3	0.7	0.7
Diabetes diagnosed by doctor	0.4	0.7	1.2	1.1	-0.4	-0.9
Commuting to job workplace: Walk	0.4	0.4	0.7	-0.5	0.5	0.9
Medication: Paracetamol	0.4	0.7	1.4	-0.7	-0.4	-1.2
Medication: Lisinopril	0.4	0.5	0.7	0.4	-0.8	-0.8
Irritability	0.4	0.7	1.6	-1.3	0.1	-0.7
Vascular/heart problems diagnosed by doctor	0.4	1.1	1.6	-1.1	1.3	0.7
Pain experienced in last month	0.4	0.6	1.0	-1.0	-0.4	-0.8
Supplements: Calcium	0.4	0.4	0.6	-0.8	0.7	-0.4
Alzheimer’s Disease (in father)	0.3	0.3	0.4	0.4	0.6	0.6
Neuroticism (2016)	0.3	0.4	0.7	-0.8	0.6	-0.5
Triglycerides	0.3	0.6	1.0	0.2	1.0	0.8
Smoking Status	0.3	0.6	1.4	-0.0	-0.7	1.2
Supplements: Glucosamine	0.3	0.4	0.7	0.6	-0.8	-0.5
Financial difficulties in last 2 years	0.3	0.4	0.8	-0.9	0.2	0.5
Medication: Simvastatin	0.3	0.4	0.8	0.9	-0.7	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.8	0.0	0.7	0.9
Lung cancer (father)	0.3	0.3	0.5	0.7	-0.6	-0.3
Medication: Paracetamol	0.3	0.6	1.3	-0.5	-0.4	-1.1
Health satisfaction	0.3	0.4	0.6	-0.3	0.8	0.6
Medication for pain relief, constipation, heartburn	0.3	0.6	1.6	-0.1	-0.4	-1.2
Medication: Blood pressure	0.3	0.6	0.7	0.6	-0.8	-0.8
Migraine (self-reported)	0.3	0.4	0.7	-0.4	0.5	0.8
Medication: Seretide 50 evohaler	0.3	0.3	0.6	-0.7	0.4	-0.5
Number of full sisters	0.3	0.4	0.8	-0.4	0.4	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	1.0	0.3	-0.0
Hypertension (Self-reported)	0.3	0.7	1.0	0.7	-1.0	-0.8
Average weekly red wine intake	0.3	0.4	0.9	0.4	-0.9	-0.3
Loneliness, isolation	0.3	0.5	0.7	-0.2	0.9	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.7	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.3	1.1	-0.9	-0.0
Number of self-reported non-cancer illnesses	0.3	0.4	0.7	0.9	-0.6	-0.4
Cholesterol lowering medication	0.3	0.5	0.9	-0.4	0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	-0.8	0.5	-0.4
Heart disease (siblings)	0.3	0.4	1.1	-0.3	-0.1	1.1
Bipolar Disorder (2018)	0.2	0.4	0.8	0.9	-0.5	-0.2
Crohns Disease (2017)	0.2	0.5	1.3	0.1	0.2	-1.2
Major Depression (MDD)	0.2	0.2	0.5	-0.3	0.7	0.2
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.7	0.5	0.2
Height	0.2	3.1	7.3	-0.6	1.3	2.7
Number of treatments/medications taken	0.2	0.3	0.6	0.3	-0.5	-0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	-0.8	0.3	0.3
Medication: Metformin	0.2	0.3	0.6	0.8	0.0	-0.6
Townsend deprivation index at recruitment	0.2	0.3	0.7	0.1	-0.5	-0.8
High blood pressure	0.2	0.6	1.0	0.4	-1.0	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	0.8	0.3	-0.2
Past tobacco smoking	0.2	0.3	0.5	0.7	-0.4	-0.6
Had menopause	0.2	0.2	0.6	0.3	-0.2	0.8
Had other major operations	0.2	0.3	0.5	-0.6	0.1	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	-0.2	0.3	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.4	1.2	-0.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.2	1.1	-0.4	0.6
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-1.0	-0.2	-0.5
Blood clot in the leg (DVT)	0.2	0.2	0.3	-0.6	0.3	-0.5
Number of children fathered	0.2	0.2	0.4	0.2	0.6	0.4
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.6	0.4	0.2
Chest pain or discomfort	0.2	0.3	0.5	0.4	-0.3	0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.5	0.7	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.3	-1.2	-0.2	-0.2
Long-standing illness, disability or infirmity	0.2	0.3	0.5	0.6	0.1	-0.7
Eye problems/disorders: Cataract	0.2	0.2	0.6	0.8	-0.1	0.0
Smoking status: Current	0.2	0.4	0.9	0.0	-0.6	0.9
Average weekly champagne plus white wine intake	0.2	0.2	0.7	0.1	0.1	-0.8
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	0.7	0.2	-0.6
High cholesterol (Self-reported)	0.2	0.3	0.8	-0.9	-0.1	-0.4
Illnesses of father: High blood pressure	0.2	0.2	0.7	0.2	-0.8	0.0
Average weekly beer plus cider intake	0.2	0.2	0.4	0.3	-0.4	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.8	0.4	-0.0
Depression (Nagel 2018)	0.1	0.2	0.3	-0.1	0.5	0.6
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.3	0.9	0.3
Ovarian Cancer	0.1	0.2	0.3	-0.6	0.3	0.3
Rheumatoid Arthritis	0.1	0.2	0.3	-0.4	0.5	0.3
Waist Hip Ratio (WHR)	0.1	0.3	0.7	0.8	-0.4	-0.1
Cardiovascular Disease	0.1	0.5	0.7	-0.8	-0.3	-0.8
Hair Pigment	0.1	3.1	6.6	-1.1	1.3	2.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.2	0.1	-0.3
Supplements: Zinc	0.1	0.2	0.3	-0.3	-0.5	-0.3
Diabetes (father)	0.1	0.1	0.2	0.4	-0.0	-0.3
Pack years adult smoking proportion	0.1	0.2	0.4	0.2	-0.3	0.6
Trunk fat percentage	0.1	0.6	1.0	-0.9	-0.1	-1.0
Maternal smoking around birth	0.1	0.2	0.3	0.5	-0.6	0.0
Sitting height	0.1	0.4	0.8	0.5	-0.3	0.9
Qualifications: None of the above	0.1	0.2	0.5	0.2	0.3	-0.7
Headache pain in last month	0.1	0.1	0.3	-0.5	-0.1	-0.1
Medication: Allopurinol	0.1	0.1	0.2	0.3	0.5	0.2
Knee pain experienced in last month	0.1	0.1	0.2	0.3	0.4	0.1
Smoking status: Previous	0.1	0.1	0.2	-0.4	0.4	0.2
Ever had bowel cancer screening	0.1	0.1	0.2	-0.4	-0.1	-0.5
Medication for cholesterol	0.1	0.2	0.4	-0.3	-0.4	-0.6
Mineral and other dietary supplements	0.1	0.1	0.4	0.0	-0.6	0.0
Mother’s age at death	0.1	0.2	0.3	0.2	-0.5	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	0.5	0.1	0.5
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.2	0.5	0.1
Medication: Atorvastatin	0.1	0.1	0.2	0.2	-0.1	0.4
Alcohol drinker status: Never	0.1	0.1	0.2	-0.4	-0.1	-0.4
Unable to work because of sickness or disability	0.1	0.2	0.3	-0.3	0.5	0.5
Alcohol drinker status: Previous	0.1	0.2	0.2	0.4	0.3	0.5
Pack years of smoking	0.1	0.1	0.2	0.3	-0.5	0.3
Tanning	0.0	0.1	0.4	0.6	-0.1	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	0.1	0.4	0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	-0.4	-0.3	-0.2
Alcohol intake frequency.	0.0	0.1	0.2	0.5	0.2	-0.2
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.1	0.3	-0.1
Number of operations (self-reported)	0.0	0.0	0.1	-0.2	-0.3	0.0
Fractured/broken bones in last 5 years	0.0	0.0	0.1	0.3	0.0	-0.1

Hub : Genes

MKL1

Models

Trait associations