Hub : Genes

MKL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0517 0.0238 0.0010 0.017 NA 0.031 NA 0.017 0.0077 NA 0.00042 NA 0.0069
2 TCGA Colon Adenocarcinoma 0.0530 0.0340 0.0079 0.032 0.035 0.019 NA 0.021 0.0060 0.0039 0.02600 NA 0.0210
3 TCGA Stomach Adenocarcinoma 0.0500 0.0270 0.0020 0.014 0.016 0.002 NA 0.008 0.0310 0.0220 0.23000 NA 0.0820

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.4 0.8 0.9 -0.5 -0.2
Bipolar Disorder or Schizophrenia 1.2 3.0 5.2 1.5 -1.3 -2.3
Depressed Affect (Nagel 2018) 0.6 1.3 2.3 -1.1 1.5 0.8
Depression (Nagel 2018) 0.1 0.2 0.3 -0.1 0.5 0.6
Intelligence (Savage-Jansen 2018) 0.7 2.3 4.5 1.5 -0.3 2.1
Neuroticism (Nagel 2018) 2.2 5.3 7.6 -2.5 2.8 1.4
Schizophrenia (2018) 1.7 3.6 7.6 1.2 -1.4 -2.8
Schizophrenia vs Biploar Disorder 1.4 1.8 3.5 1.9 -0.6 -1.2
Worry (Nagel 2018) 4.5 9.5 12.5 -3.1 3.5 2.5
Alzheimer’s Disease (in mother) 1.9 2.2 5.0 -2.2 1.0 0.9
Alzheimer’s Disease (in father) 0.3 0.3 0.4 0.4 0.6 0.6
Alzheimer’s Disease (including proxy) 0.6 0.9 1.6 -1.3 1.0 0.5
Crohns Disease (2017) 0.2 0.5 1.3 0.1 0.2 -1.2
Irritable Bowel Disease (IBD) 0.1 0.3 0.8 -0.3 0.9 0.3
Ulcerative Colitis (UC) 1.0 1.9 3.0 -1.1 1.2 1.7
Major Depression (MDD) 0.2 0.2 0.5 -0.3 0.7 0.2
Reaction Time 1.0 1.9 4.9 -2.2 0.8 0.2
Verbal and Numeric Reasoning (VNR) 0.8 1.9 3.0 1.7 0.4 1.6
Breast Cancer 45.3 109.0 146.4 7.6 -12.1 -11.1
Ovarian Cancer 0.1 0.2 0.3 -0.6 0.3 0.3
Prostate Cancer 2.5 3.5 10.4 -3.2 0.0 0.0
Age at First Birth 0.6 0.8 1.5 0.6 -1.2 -0.7
Bipolar Disorder (2011) 1.9 1.9 3.2 1.1 -1.8 -1.0
Body Mass Index (BMI) (2010) 1.0 1.4 2.6 1.1 -0.6 -1.6
Coronary Artery Disease (CAD) 0.5 0.6 1.3 -0.2 0.6 1.1
Crohns Disease (2012) 0.7 1.1 2.2 -0.8 1.5 0.5
Mean Putamen Volume 0.4 0.4 0.7 0.5 -0.6 -0.8
Fasting Glucose 0.8 0.9 1.7 0.2 1.3 1.1
HbA1C 1.2 1.3 2.5 1.0 -0.7 -1.6
HDL Cholesterol 0.6 1.0 1.3 -1.0 0.7 1.2
LDL Cholesterol 1.0 1.6 3.5 -0.3 -1.1 -1.9
Lupus 1.0 1.6 2.8 0.8 1.2 1.7
Neuroticism (2016) 0.3 0.4 0.7 -0.8 0.6 -0.5
Primary Biliary Cirrhosis 0.2 0.3 0.5 -0.7 0.5 0.2
Rheumatoid Arthritis 0.1 0.2 0.3 -0.4 0.5 0.3
Schizophrenia (2014) 2.7 6.0 10.1 1.9 -2.0 -3.2
Triglycerides 0.3 0.6 1.0 0.2 1.0 0.8
Type 2 Diabetes (T2D) (2012) 1.7 2.0 4.2 -2.1 1.3 -0.1
Ulcerative Colitis 0.7 1.1 1.8 0.7 0.9 1.3
Blood Eosinophil Count 0.4 3.4 5.7 0.7 -2.4 -2.0
Blood Platelet Count 0.5 5.3 11.7 0.9 -3.4 -1.9
Blood Red Count 0.5 4.8 12.2 0.5 1.4 3.5
Blood White Count 0.9 6.4 7.9 2.8 -2.5 -2.3
Heel T-Score 2.4 19.4 33.1 -1.5 4.8 5.8
BMI 5.4 31.4 47.5 4.3 -5.4 -6.9
Height 0.2 3.1 7.3 -0.6 1.3 2.7
Waist Hip Ratio (WHR) 0.1 0.3 0.7 0.8 -0.4 -0.1
Systolic Blood Pressure 2.0 9.9 18.8 -1.2 3.1 4.3
Smoking Status 0.3 0.6 1.4 -0.0 -0.7 1.2
Allergy or Eczema 1.8 4.7 12.9 -3.6 1.0 -0.5
Cardiovascular Disease 0.1 0.5 0.7 -0.8 -0.3 -0.8
Hypothyroidism (self reported) 2.5 5.7 9.1 3.0 -2.3 -1.6
Respiratory disease 2.3 5.1 7.9 -1.6 2.8 2.2
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.4 1.2 -0.7 -0.8
Lung FEV1/FVC ratio 5.5 27.8 35.3 4.1 -5.6 -5.9
Lung FVC 0.4 2.1 3.6 1.9 -0.7 1.4
Neuroticism 1.9 4.6 6.8 -2.0 2.6 1.8
Chronotype (morning person) 1.5 3.5 10.3 0.4 -0.3 -3.2
Hair Pigment 0.1 3.1 6.6 -1.1 1.3 2.6
Tanning 0.0 0.1 0.4 0.6 -0.1 -0.0
Hand grip strength (left) 0.8 2.2 3.4 1.8 -1.8 -0.1
Number of treatments/medications taken 0.2 0.3 0.6 0.3 -0.5 -0.8
Average weekly spirits intake 0.8 0.9 2.1 0.9 0.1 1.4
Sensitivity / hurt feelings 0.6 1.0 1.8 -0.9 1.3 0.6
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.6 -0.7 0.9 1.3
Hearing difficulty/problems: Yes 0.8 1.3 2.2 -0.6 1.1 1.5
Relative age of first facial hair 1.5 3.1 6.4 -1.1 1.2 2.5
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.2 0.2 -0.7 -1.5
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.7 -0.8 0.3 0.3
Ever had hysterectomy (womb removed) 5.3 6.0 8.3 -2.5 2.9 1.9
Systolic blood pressure, automated reading 0.5 1.5 2.8 -0.3 1.3 1.7
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 -0.2 0.1 -0.3
Angina 2.2 2.9 4.9 2.2 -0.2 1.9
Medication for hormone replacement therapy 1.4 1.6 1.8 -1.3 1.3 1.1
Vitamin and mineral supplements 0.7 0.9 2.7 0.1 -1.6 -0.1
Supplements: Zinc 0.1 0.2 0.3 -0.3 -0.5 -0.3
Medication: Co-codamol 0.4 0.4 1.0 1.0 -0.5 0.1
Medication: Metformin 0.2 0.3 0.6 0.8 0.0 -0.6
Diabetes (father) 0.1 0.1 0.2 0.4 -0.0 -0.3
Diabetes (mother) 0.8 1.0 2.0 1.4 -1.0 -0.4
Severe depression (siblings) 1.4 1.5 2.2 0.6 -1.5 -1.4
Pack years adult smoking proportion 0.1 0.2 0.4 0.2 -0.3 0.6
Impedance of leg (right) 6.7 32.7 43.3 -4.4 6.0 6.6
Leg fat-free mass (left) 3.0 16.0 19.7 3.0 -4.4 -4.4
Trunk fat percentage 0.1 0.6 1.0 -0.9 -0.1 -1.0
Hand grip strength (right) 0.5 1.4 2.1 1.5 -1.4 0.2
Townsend deprivation index at recruitment 0.2 0.3 0.7 0.1 -0.5 -0.8
Current tobacco smoking 0.5 0.9 2.6 0.2 -0.1 1.6
Average weekly fortified wine intake 1.1 1.3 1.9 -0.8 1.4 1.2
Maternal smoking around birth 0.1 0.2 0.3 0.5 -0.6 0.0
Fed-up feelings 1.0 1.8 2.5 0.6 -1.6 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.1 0.1 0.1 0.4 0.2
Relative age voice broke 0.7 1.0 1.8 -0.6 1.0 1.3
Taking other prescription medications 0.8 1.3 1.6 -1.1 1.3 0.9
Age when periods started (menarche) 0.9 2.1 2.8 -1.5 1.1 1.7
Bilateral oophorectomy (both ovaries removed) 3.5 4.1 5.5 -2.3 1.9 1.8
Heel bone mineral density (BMD) T-score, automated (left) 4.8 10.8 18.7 -1.7 3.3 4.3
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.7 0.3 -1.3 -0.9
Qualifications: CSEs or equivalent 1.1 1.4 2.5 -1.1 1.6 0.7
Serious illness, injury or assault to yourself 2.3 2.8 4.5 -1.1 1.7 2.1
High blood pressure 0.2 0.6 1.0 0.4 -1.0 -0.8
Hayfever, allergic rhinitis or eczema 2.1 4.6 12.4 -3.5 0.5 -1.0
Multivitamins +/- minerals 0.4 0.6 1.5 0.3 0.3 -1.2
Stomach or abdominal pain in last month 1.3 1.6 3.1 1.8 0.3 1.3
Supplements: Glucosamine 0.3 0.4 0.7 0.6 -0.8 -0.5
Diverticular disease/diverticulitis (self-reported) 2.3 2.7 5.0 1.6 0.7 2.2
Medication: Atenolol 2.0 2.5 5.0 2.2 -1.3 -1.0
Medication: Levothyroxine sodium 0.6 1.0 2.5 1.6 -0.6 -0.3
Sitting height 0.1 0.4 0.8 0.5 -0.3 0.9
Chronic bronchitis/emphysema (father) 0.2 0.3 0.7 0.8 0.3 -0.2
High blood pressure (mother) 1.6 2.2 2.6 1.5 -1.6 -1.3
Body mass index (BMI) 5.1 21.5 29.9 3.4 -4.8 -5.5
Impedance of leg (left) 7.2 35.2 44.1 -4.8 6.2 6.6
Leg predicted mass (left) 3.0 15.9 19.4 3.0 -4.4 -4.4
Trunk fat mass 0.5 2.2 4.3 0.4 -1.5 -2.1
Waist circumference 3.0 10.8 17.9 2.0 -3.2 -4.2
Number of incorrect matches in round 0.8 1.4 2.7 -1.6 -0.2 -1.2
Past tobacco smoking 0.2 0.3 0.5 0.7 -0.4 -0.6
Alcohol usually taken with meals 0.5 0.7 1.7 -1.3 0.7 -0.1
Nervous feelings 3.0 5.6 8.4 -2.1 2.9 2.0
Frequency of tenseness / restlessness in last 2 weeks 3.2 5.0 5.7 -1.9 2.4 2.4
Hearing difficulty/problems with background noise 1.4 2.2 3.6 -1.4 1.9 1.0
Hair/balding pattern: Pattern 2 0.5 0.7 1.7 1.3 -0.5 0.1
Had menopause 0.2 0.2 0.6 0.3 -0.2 0.8
Had other major operations 0.2 0.3 0.5 -0.6 0.1 -0.7
Forced vital capacity (FVC) 0.6 2.2 5.7 0.2 1.0 2.4
Heel bone mineral density (BMD) T-score, automated (right) 4.7 10.7 14.3 -2.1 3.7 3.8
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.7 -0.2 0.3 0.8
Qualifications: None of the above 0.1 0.2 0.5 0.2 0.3 -0.7
Financial difficulties in last 2 years 0.3 0.4 0.8 -0.9 0.2 0.5
Mouth/teeth dental problems 1.8 2.8 6.3 -0.7 -1.3 -2.5
Heart attack 3.8 4.8 10.3 3.2 -2.0 -0.4
Allergy 1.4 3.3 8.4 2.9 -1.2 0.4
Pain all over the body in last month 1.1 1.1 1.9 -0.4 1.4 1.2
Diabetes (self-reported) 1.3 2.1 3.2 1.8 -1.1 -1.3
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.1 -1.5 -0.6 -0.9
Medication: Ramipril 0.5 0.6 1.1 0.4 0.7 1.1
Medication: Simvastatin 0.3 0.4 0.8 0.9 -0.7 -0.3
Fluid intelligence score 1.0 2.1 4.6 2.1 -0.6 1.1
Illnesses of siblings 1.0 1.4 3.0 -1.7 1.1 0.2
Neuroticism score 2.3 4.8 6.6 -2.6 2.3 1.6
Weight 2.4 11.8 15.8 2.4 -3.7 -4.0
Impedance of arm (right) 9.2 42.8 50.7 -5.6 7.1 6.8
Arm fat percentage (right) 1.8 7.1 12.0 1.5 -2.6 -3.5
Trunk fat-free mass 3.7 21.0 24.7 4.3 -5.0 -4.4
Hip circumference 0.7 2.8 6.2 0.1 -1.5 -2.5
Time employed in main current job 1.7 2.0 4.3 -0.4 -1.3 -2.1
Alcohol intake versus 10 years previously 0.5 0.8 1.3 -0.2 1.0 1.1
Father’s age at death 1.5 2.0 3.2 -0.5 1.8 1.6
Worrier / anxious feelings 1.4 2.6 4.1 -2.0 1.7 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 0.8 0.0 0.7 0.9
Falls in the last year 6.4 8.6 10.5 -2.6 2.9 3.2
Hair/balding pattern: Pattern 3 0.6 0.8 2.1 -1.5 0.6 0.2
Number of live births 1.8 2.5 5.8 -0.9 1.0 2.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.4 1.2 -0.2 0.9
Pulse rate 1.8 3.1 3.7 1.4 -1.9 -1.9
Happiness 0.4 0.5 0.7 0.7 -0.7 -0.8
Noisy workplace 0.6 0.7 1.1 -1.0 1.1 0.3
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.1 -0.4 -0.3 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.6 0.2 0.1 1.6
Mouth/teeth dental problems: Dentures 0.6 1.0 2.3 1.5 0.1 0.9
Asthma 0.6 1.2 1.7 -1.0 1.3 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.0 -0.2 0.8 1.0
Medication: Cholesterol lowering 0.8 1.2 1.5 1.1 -1.2 -0.9
Depression (self-reported) 0.4 0.5 0.5 0.7 0.7 0.6
Medication: Lansoprazole 1.0 1.1 1.7 1.0 0.8 1.3
Prospective memory result 0.6 0.7 1.6 -1.3 0.6 0.3
Lung cancer (father) 0.3 0.3 0.5 0.7 -0.6 -0.3
Illnesses of mother 0.8 1.0 1.3 -0.9 1.1 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.2 1.1 -0.4 0.6
Pulse wave Arterial Stiffness index 3.8 4.4 5.7 2.0 -1.9 -2.4
Impedance of arm (left) 10.5 48.5 56.8 -6.6 7.5 6.8
Arm fat mass (right) 2.9 11.9 17.5 2.3 -3.6 -4.2
Trunk predicted mass 3.9 22.0 25.5 4.5 -5.1 -4.5
Standing height 0.4 3.9 6.0 -1.7 1.7 2.4
Length of working week for main job 0.7 0.8 1.5 -0.9 0.2 -1.2
Exposure to tobacco smoke at home 3.4 3.8 4.7 -2.2 1.9 1.8
Breastfed as a baby 1.1 1.3 2.0 -0.7 1.2 1.4
Tense / ‘highly strung’ 3.0 5.0 6.5 -2.6 2.4 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 3.0 4.6 7.8 -0.8 2.3 2.8
Hair/balding pattern: Pattern 4 0.2 0.4 0.9 -1.0 -0.2 -0.5
Birth weight of first child 0.5 1.0 1.5 -0.1 -1.2 -1.2
Peak expiratory flow (PEF) 1.4 3.2 3.9 1.6 -2.0 -1.8
Pulse wave reflection index 2.3 2.8 4.5 1.2 -1.5 -2.1
Ever highly irritable/argumentative for 2 days 1.6 1.9 2.3 -1.2 1.5 1.5
Loud music exposure frequency 1.4 1.5 2.2 -0.2 1.5 1.5
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 3.4 -1.6 1.1 1.8
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 0.8 -0.8 0.6 0.9
Blood clot in the leg (DVT) 0.2 0.2 0.3 -0.6 0.3 -0.5
Medication: Paracetamol 0.3 0.6 1.3 -0.5 -0.4 -1.1
Headache pain in last month 0.1 0.1 0.3 -0.5 -0.1 -0.1
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.3 -0.6 1.1 1.1
Glaucoma (self-reported) 7.0 8.2 11.7 -2.0 3.0 3.4
Gout (self-reported) 0.4 0.5 1.2 -1.1 0.5 0.2
Hypothyroidism/myxoedema (self-reported) 1.6 3.2 4.3 2.1 -1.9 -1.3
Medication: Amlodipine 3.6 5.1 6.7 1.6 -2.4 -2.6
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.2 -0.5 1.1 0.6
Birth weight 3.8 8.2 12.5 2.9 -3.5 -1.9
Chronic bronchitis/emphysema (mother) 1.5 1.7 2.2 1.5 -1.4 -1.1
High blood pressure (siblings) 0.8 1.2 1.8 1.3 -1.1 -0.7
Forced vital capacity (FVC), Best measure 0.5 1.7 4.6 -0.0 0.8 2.1
Body fat percentage 0.4 1.5 3.5 -0.0 -1.0 -1.9
Leg fat percentage (right) 1.0 3.7 5.5 1.2 -2.0 -2.4
Arm fat-free mass (right) 4.3 22.2 25.9 4.3 -5.1 -4.7
Exposure to tobacco smoke outside home 1.8 2.4 4.6 -1.3 1.0 2.2
Comparative body size at age 10 5.9 16.4 28.6 1.7 -4.2 -5.3
Number of full brothers 2.7 3.4 6.4 -0.6 1.9 2.5
Worry too long after embarrassment 0.8 1.4 2.1 -1.3 1.4 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 3.5 4.6 6.2 -1.7 2.5 2.1
Wheeze or whistling in the chest in last year 0.9 1.6 3.5 -1.9 1.2 -0.2
Number of children fathered 0.2 0.2 0.4 0.2 0.6 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.9 -0.9 0.9 0.0
Age at first live birth 2.3 4.2 7.5 0.6 -2.1 -2.7
Pulse wave peak to peak time 4.7 5.5 7.0 -2.2 2.1 2.7
Health satisfaction 0.3 0.4 0.6 -0.3 0.8 0.6
Shortness of breath walking on level ground 4.4 5.2 6.0 -2.2 2.5 2.2
Qualifications: College or University degree 0.6 1.8 3.2 1.1 -1.8 -1.0
Eye problems/disorders: None of the above 0.2 0.2 0.4 -0.6 0.4 0.2
Mouth/teeth dental problems: Loose teeth 3.3 3.9 6.2 -0.6 2.3 2.5
Emphysema/chronic bronchitis 1.4 1.6 3.8 -0.3 2.0 0.9
Medication for pain relief, constipation, heartburn 0.3 0.6 1.6 -0.1 -0.4 -1.2
Neck or shoulder pain in last month 0.8 1.2 2.3 0.1 1.1 1.5
Medication: Blood pressure 0.3 0.6 0.7 0.6 -0.8 -0.8
Angina (self-reported) 2.1 2.8 4.5 2.1 -0.2 1.9
Migraine (self-reported) 0.3 0.4 0.7 -0.4 0.5 0.8
Medication: Ibuprofen 1.2 1.4 2.1 -0.7 1.4 1.3
Medication: Allopurinol 0.1 0.1 0.2 0.3 0.5 0.2
Medication: Omeprazole 1.1 1.4 3.5 0.2 0.7 1.9
Medication: Seretide 50 evohaler 0.3 0.3 0.6 -0.7 0.4 -0.5
Mean time to correctly identify matches 0.7 1.4 3.9 -2.0 0.6 -0.1
Heart disease (mother) 0.9 1.1 2.4 0.8 -1.5 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.7 4.4 4.7 -2.1 2.0 2.2
Whole body fat mass 1.2 5.2 9.0 1.0 -2.3 -3.0
Leg fat mass (right) 2.1 8.0 11.9 1.7 -3.0 -3.4
Arm predicted mass (right) 4.3 21.9 25.3 4.3 -5.0 -4.7
Pulse rate, automated reading 0.9 2.8 3.1 1.5 -1.7 -1.8
Alcohol intake frequency. 0.0 0.1 0.2 0.5 0.2 -0.2
Comparative height size at age 10 0.5 2.8 3.9 -1.4 2.0 1.6
Number of full sisters 0.3 0.4 0.8 -0.4 0.4 0.9
Suffer from ‘nerves’ 8.5 13.3 15.0 -3.3 3.9 3.7
Overall health rating 0.4 0.9 1.6 1.3 0.7 0.7
Chest pain or discomfort 0.2 0.3 0.5 0.4 -0.3 0.7
Had major operations 0.7 0.9 1.4 1.2 0.1 1.1
Age at last live birth 0.6 0.9 1.7 -0.5 -1.3 -0.9
Family relationship satisfaction 2.8 3.5 4.8 2.2 -2.0 -1.3
Leg pain on walking 1.4 1.8 3.4 -1.1 1.8 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.0 1.0 0.3 -0.0
Commuting to job workplace: Car/motor vehicle 1.5 1.7 2.8 -0.6 1.7 1.4
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 -0.5 0.7 -0.0
Medication: Aspirin 1.2 1.5 2.8 1.3 0.5 1.7
Supplements: Vitamin C 1.5 1.8 3.5 -0.1 1.9 1.3
Knee pain experienced in last month 0.1 0.1 0.2 0.3 0.4 0.1
Hypertension (Self-reported) 0.3 0.7 1.0 0.7 -1.0 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.6 3.3 -0.7 0.9 1.8
Illnesses of father: Heart disease 1.9 2.6 4.9 1.2 -2.2 -1.2
Illnesses of siblings: Diabetes 1.8 2.2 4.5 2.1 -1.2 -0.8
Smoking status: Previous 0.1 0.1 0.2 -0.4 0.4 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.3 -1.2 -0.2 -0.2
Whole body fat-free mass 3.8 21.9 25.7 4.2 -5.1 -4.8
Leg fat-free mass (right) 2.9 15.4 19.3 2.9 -4.3 -4.4
Arm fat percentage (left) 1.5 6.1 11.5 1.0 -2.4 -3.4
Average weekly red wine intake 0.3 0.4 0.9 0.4 -0.9 -0.3
Handedness (chirality/laterality): Left-handed 2.0 2.4 3.2 1.1 -1.7 -1.8
Mood swings 1.8 3.2 7.7 -2.8 1.4 0.3
Loneliness, isolation 0.3 0.5 0.7 -0.2 0.9 0.8
Long-standing illness, disability or infirmity 0.2 0.3 0.5 0.6 0.1 -0.7
Ever had bowel cancer screening 0.1 0.1 0.2 -0.4 -0.1 -0.5
Diabetes diagnosed by doctor 0.4 0.7 1.2 1.1 -0.4 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 0.7 -0.6 -0.3
Friendships satisfaction 2.0 2.5 4.7 1.3 -1.0 -2.2
Qualifications: nursing, teaching 1.3 2.1 4.7 0.8 -2.2 -0.9
Commuting to job workplace: Walk 0.4 0.4 0.7 -0.5 0.5 0.9
Eye problems/disorders: Cataract 0.2 0.2 0.6 0.8 -0.1 0.0
Mouth/teeth dental problems: Mouth ulcers 4.3 6.8 9.0 -2.0 2.7 3.0
Medication for cholesterol 0.1 0.2 0.4 -0.3 -0.4 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 2.6 -1.6 1.4 1.0
Back pain experienced in last month 0.5 0.8 1.5 -0.1 0.9 1.2
Mineral and other dietary supplements 0.1 0.1 0.4 0.0 -0.6 0.0
Breast cancer (self-reported) 10.6 12.7 17.8 -3.5 4.2 2.9
Asthma (self-reported) 0.5 1.1 1.7 -0.9 1.3 0.9
Osteoporosis (self-reported) 2.1 2.6 3.8 0.6 -1.9 -2.0
Osteoarthritis (self-reported) 1.3 1.7 2.1 1.1 1.3 1.5
Medication: Aspirin 1.1 1.4 2.6 1.2 0.5 1.6
Medication: Gliclazide 1.3 1.5 2.5 0.3 -1.4 -1.6
Illnesses of father: None of the above (group 1) 0.0 0.0 0.1 -0.1 0.3 -0.1
Smoking status: Current 0.2 0.4 0.9 0.0 -0.6 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.3 1.1 -0.9 -0.0
Whole body water mass 3.9 22.5 26.0 4.3 -5.1 -4.8
Leg predicted mass (right) 2.8 15.0 19.0 2.8 -4.3 -4.4
Arm fat mass (left) 3.1 12.9 19.7 2.3 -3.7 -4.4
Number of self-reported non-cancer illnesses 0.3 0.4 0.7 0.9 -0.6 -0.4
Average weekly champagne plus white wine intake 0.2 0.2 0.7 0.1 0.1 -0.8
Miserableness 1.9 3.3 4.4 -2.1 1.9 1.4
Guilty feelings 1.7 2.5 4.1 -2.0 1.6 1.0
Wears glasses or contact lenses 0.5 0.6 0.7 0.5 -0.8 -0.8
Ever taken oral contraceptive pill 1.2 1.4 3.9 -2.0 0.4 0.2
Hearing aid user 1.2 1.4 3.4 -1.8 0.9 -0.1
Mother’s age at death 0.1 0.2 0.3 0.2 -0.5 -0.4
Financial situation satisfaction 0.5 0.6 1.0 -0.0 -1.0 -0.9
Tinnitus: Yes, now most or all of the time 3.5 4.0 6.2 -1.6 1.8 2.5
Commuting to job workplace: Public transport 0.5 0.6 0.8 -0.9 -0.8 0.3
Eye problems/disorders: Glaucoma 5.6 6.6 12.0 -0.7 2.7 3.5
Medication: Blood pressure 0.7 1.3 1.6 1.3 -1.0 -1.2
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.3 0.5 0.1 0.5
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.5 0.7 0.2 -0.6
High cholesterol (Self-reported) 0.2 0.3 0.8 -0.9 -0.1 -0.4
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.2 0.5 0.1
Medication: Paracetamol 0.4 0.7 1.4 -0.7 -0.4 -1.2
Medication: Lisinopril 0.4 0.5 0.7 0.4 -0.8 -0.8
Medication: Atorvastatin 0.1 0.1 0.2 0.2 -0.1 0.4
Illnesses of father: High blood pressure 0.2 0.2 0.7 0.2 -0.8 0.0
Alcohol drinker status: Never 0.1 0.1 0.2 -0.4 -0.1 -0.4
Ever smoked 0.9 1.6 3.9 -0.3 1.0 2.0
Basal metabolic rate 3.4 19.0 22.4 3.6 -4.7 -4.6
Leg fat percentage (left) 1.0 3.5 5.5 1.1 -1.9 -2.3
Arm fat-free mass (left) 4.6 23.2 26.8 4.5 -5.2 -4.8
Number of operations (self-reported) 0.0 0.0 0.1 -0.2 -0.3 0.0
Average weekly beer plus cider intake 0.2 0.2 0.4 0.3 -0.4 0.7
Irritability 0.4 0.7 1.6 -1.3 0.1 -0.7
Risk taking 1.8 2.7 4.3 -1.7 -1.0 -2.1
Ever had prostate specific antigen (PSA) test 1.6 1.8 3.2 0.4 -1.5 -1.8
Fractured/broken bones in last 5 years 0.0 0.0 0.1 0.3 0.0 -0.1
Age started oral contraceptive pill 0.9 1.1 1.8 -0.1 -1.3 -1.3
Diastolic blood pressure, automated reading 5.3 16.5 18.4 4.3 -4.1 -3.8
Ever depressed for a whole week 2.5 3.1 5.4 -0.7 1.9 2.3
Unable to work because of sickness or disability 0.1 0.2 0.3 -0.3 0.5 0.5
Commuting to job workplace: Cycle 2.2 2.7 5.1 0.2 -1.7 -2.3
Myopia 0.5 0.7 1.1 0.8 -0.6 1.0
Vascular/heart problems diagnosed by doctor 0.4 1.1 1.6 -1.1 1.3 0.7
Cholesterol lowering medication 0.3 0.5 0.9 -0.4 0.7 0.9
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 4.9 0.1 1.0 2.2
Pain experienced in last month 0.4 0.6 1.0 -1.0 -0.4 -0.8
Supplements: Calcium 0.4 0.4 0.6 -0.8 0.7 -0.4
Basal cell carcinoma (self-reported) 0.2 0.2 0.6 0.8 0.4 -0.0
Heart attack/myocardial infarction (self-reported) 3.6 4.7 10.5 3.2 -1.9 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.7 -0.8 0.5 -0.4
Heart disease (siblings) 0.3 0.4 1.1 -0.3 -0.1 1.1
Alcohol drinker status: Previous 0.1 0.2 0.2 0.4 0.3 0.5
Pack years of smoking 0.1 0.1 0.2 0.3 -0.5 0.3
Impedance of whole body 10.4 53.0 61.3 -6.4 7.8 7.5
Leg fat mass (left) 2.0 7.7 11.7 1.6 -3.0 -3.4
Arm predicted mass (left) 4.5 23.0 25.6 4.5 -5.1 -4.8