Best TWAS P=4.63e-14 · Best GWAS P=1.06e-13 conditioned to 0.00189
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AFF3 | 0.31 | 0.24 | enet | 32 | 0.25 | 9.2e-31 | -5.3 | -5.5 | 3.5e-08 | 0.68 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | AFF3 | 0.14 | 0.06 | lasso | 5 | 0.07 | 1.2e-04 | -7.2 | -7.5 | 4.6e-14 | 0.69 | 0.02 | 0.98 | TRUE |
| 3 | GTEx | Artery Tibial | AFF3 | 0.06 | 0.04 | enet | 6 | 0.04 | 4.3e-04 | 3.6 | -5.2 | 1.6e-07 | 0.74 | 0.16 | 0.78 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | LONRF2 | 0.05 | 0.03 | lasso | 2 | 0.02 | 9.3e-03 | 5.1 | -5.8 | 5.6e-09 | 0.42 | 0.31 | 0.13 | FALSE |
| 5 | GTEx | Thyroid | CHST10 | 0.05 | 0.05 | lasso | 5 | 0.03 | 2.6e-03 | -4.8 | -5.9 | 4.1e-09 | 0.39 | 0.48 | 0.26 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | AFF3 | 0.31 | 0.24 | enet | 38 | 0.25 | 3.5e-32 | -5.3 | -5.5 | 4.5e-08 | 0.68 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LONRF2 | 0.06 | 0.04 | blup | 69 | 0.04 | 3.4e-05 | 4.8 | -6.1 | 1.1e-09 | 0.53 | 0.45 | 0.53 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LONRF2 | 0.05 | 0.08 | lasso | 2 | 0.08 | 2.9e-05 | 5.3 | -5.2 | 2.3e-07 | 0.48 | 0.21 | 0.16 | FALSE |