TWAS hub - LONRF2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.0754	0.0334	2.1e-03	0.001	NA	-0.002	NA	0.001	2.8e-01	NA	4.8e-01	NA	2.4e-01
2	GTEx	Muscle Skeletal	0.0670	0.0233	1.7e-05	0.085	NA	0.067	NA	0.081	1.0e-08	NA	4.1e-07	NA	2.4e-08
3	GTEx	Skin Sun Exposed Lower leg	0.0530	0.0260	5.8e-03	0.032	NA	0.017	NA	0.019	1.1e-03	NA	1.3e-02	NA	9.3e-03
4	METSIM	Adipose	0.0439	0.0227	1.8e-03	0.007	0.012	0.009	0.015	0.011	2.4e-02	5.2e-03	1.4e-02	0.0019	8.6e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0589	0.0296	3.3e-06	0.040	0.038	0.028	NA	0.026	2.3e-05	3.4e-05	3.3e-04	NA	5.7e-04
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0480	0.0270	2.1e-03	0.085	0.034	0.067	NA	0.079	1.4e-05	5.0e-03	1.1e-04	NA	2.9e-05
7	TCGA	Brain Lower Grade Glioma	0.0746	0.0363	7.4e-06	0.033	0.038	0.037	NA	0.015	1.1e-04	3.2e-05	4.7e-05	NA	7.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Qualifications: A levels/AS levels or equivalent	12.3	27.3	38.3	2.0	5.4	5.8	5.5	6.2	6.2	4.2
Qualifications: College or University degree	12.3	38.8	67.6	3.3	6.6	7.4	5.5	8.2	7.3	3.4
Intelligence (Savage-Jansen 2018)	12.0	36.9	55.1	0.5	7.1	7.4	5.3	7.3	7.3	4.1
Commuting to job workplace: Public transport	11.7	14.0	21.7	1.6	4.4	4.7	3.0	4.6	4.0	2.8
Qualifications: None of the above	10.2	21.8	31.5	-1.3	-5.3	-5.5	-4.9	-5.6	-5.0	-3.4
Verbal and Numeric Reasoning (VNR)	9.3	22.2	34.5	0.8	5.4	5.6	4.1	5.9	5.8	3.0
Alcohol usually taken with meals	9.0	14.6	21.8	3.5	4.2	4.3	4.4	4.7	3.1	1.5
Financial difficulties in last 2 years	8.1	10.9	18.1	-0.2	-4.0	-4.2	-2.8	-4.2	-3.4	-2.5
Age at last live birth	7.5	10.9	23.2	1.2	3.1	4.0	1.8	4.8	4.1	2.4
Fluid intelligence score	7.4	15.5	24.2	0.1	4.8	4.8	3.2	4.4	4.9	2.9
Commuting to job workplace: Car/motor vehicle	6.9	7.9	14.4	-1.5	-3.8	-3.6	-2.1	-2.6	-2.5	-2.8
Eye problems/disorders: Cataract	6.5	7.6	13.2	0.5	-3.2	-3.3	-2.2	-2.6	-2.5	-3.6
Leg fat percentage (left)	6.3	22.7	36.6	-1.3	-5.6	-6.0	-3.5	-6.0	-5.5	-3.2
Age at First Birth	6.2	9.0	15.3	3.6	2.8	3.0	2.1	3.5	3.9	1.2
Leg fat percentage (right)	6.2	22.4	36.1	-1.6	-5.6	-6.0	-3.4	-6.0	-5.4	-3.3
Body fat percentage	6.1	23.9	38.9	-1.2	-5.7	-6.2	-3.6	-6.2	-5.3	-3.8
Average weekly red wine intake	5.9	8.7	13.0	1.5	3.2	3.3	3.6	3.4	3.1	1.9
Trunk fat percentage	5.8	23.2	38.4	-1.0	-5.6	-6.1	-3.6	-6.2	-5.1	-3.9
Leg fat mass (right)	5.8	22.5	38.9	-1.4	-5.5	-6.2	-2.9	-6.2	-5.5	-3.2
Leg fat mass (left)	5.8	22.6	39.8	-1.3	-5.5	-6.2	-2.8	-6.3	-5.5	-3.2
Guilty feelings	5.7	8.6	11.7	3.0	3.4	3.1	2.9	3.1	2.7	2.2
Hair/balding pattern: Pattern 3	5.6	8.3	10.2	2.2	3.1	3.1	3.2	3.0	3.1	2.3
Heart attack/myocardial infarction (self-reported)	5.6	7.2	11.5	-0.7	-3.4	-3.2	-2.4	-2.6	-3.0	-2.7
Fed-up feelings	5.4	9.8	20.8	-1.0	-3.3	-4.1	-1.1	-4.6	-4.0	-1.3
Waist circumference	5.3	19.4	38.2	-0.4	-4.9	-6.0	-2.0	-6.2	-5.3	-2.6
Commuting to job workplace: Walk	5.3	5.7	9.4	1.5	3.0	3.0	1.9	3.1	2.2	1.4
Smoking Status	5.2	12.5	20.4	-3.3	-3.9	-4.2	-2.5	-4.5	-3.3	-2.6
Whole body fat mass	5.2	21.6	40.1	-1.1	-5.2	-6.0	-2.8	-6.3	-5.2	-3.3
BMI	5.1	29.9	58.8	-0.4	-6.2	-7.3	-2.9	-7.7	-5.8	-3.9
Heart attack	5.1	6.5	10.1	-0.8	-3.2	-3.0	-2.2	-2.4	-2.9	-2.5
Supplements: Zinc	4.8	5.3	13.4	0.2	2.7	2.2	3.7	1.8	2.0	2.1
Trunk fat mass	4.8	20.6	37.1	-1.3	-5.2	-5.9	-2.9	-6.1	-5.0	-3.3
Qualifications: nursing, teaching	4.6	7.2	13.6	0.6	2.4	3.2	2.1	3.4	3.7	2.2
Arm fat mass (left)	4.6	18.8	37.2	-1.1	-4.8	-5.7	-2.0	-6.1	-5.0	-2.8
Body mass index (BMI)	4.5	19.4	37.1	-0.7	-4.9	-5.8	-2.3	-6.1	-5.2	-2.7
Arm fat mass (right)	4.4	18.0	34.8	-0.8	-4.8	-5.6	-2.1	-5.9	-4.9	-2.9
Arm fat percentage (left)	4.4	17.5	31.2	-0.8	-4.8	-5.4	-2.4	-5.6	-4.7	-3.1
Arm fat percentage (right)	4.3	16.9	29.6	-0.8	-4.8	-5.3	-2.4	-5.4	-4.6	-3.1
Number of full brothers	3.8	4.8	9.4	-0.8	-2.1	-2.6	-2.1	-3.1	-2.6	-1.2
Qualifications: O levels/GCSEs or equivalent	3.7	5.9	9.3	2.2	2.2	2.3	3.1	2.6	2.3	2.2
Age started oral contraceptive pill	3.7	4.6	8.2	2.9	1.9	2.3	1.1	2.5	2.7	0.7
Age when periods started (menarche)	3.6	8.7	14.2	-3.8	-3.3	-2.9	-2.7	-2.2	-2.3	-3.1
Noisy workplace	3.6	4.4	6.8	1.7	-2.0	-2.4	-2.1	-2.6	-2.1	-1.7
Illnesses of father: Heart disease	3.4	4.8	8.8	0.6	2.1	2.5	0.9	2.8	3.0	2.3
Illness, injury, bereavement, stress in last 2 years	3.3	4.0	6.2	0.5	2.0	2.2	1.8	2.5	2.1	2.2
Hip circumference	3.2	14.0	27.1	-0.7	-4.2	-4.9	-1.4	-5.2	-4.5	-2.4
Father’s age at death	3.2	4.3	10.3	-0.2	2.3	2.8	1.4	3.2	1.9	0.9
Age at first live birth	3.2	5.7	13.8	1.4	1.6	2.5	1.2	3.7	3.6	1.0
Friendships satisfaction	3.1	3.9	6.4	1.3	2.1	2.1	2.0	2.1	1.1	2.5
Leg pain on walking	3.0	3.7	6.3	0.1	-2.2	-2.5	-0.8	-2.3	-2.4	-1.9
Townsend deprivation index at recruitment	2.9	4.1	7.7	-0.7	-1.9	-2.4	-2.4	-2.8	-2.0	-1.2
Supplements: Fish oil (including cod liver oil)	2.9	3.8	5.9	-2.0	2.4	2.3	0.4	2.4	1.7	1.5
Depressed Affect (Nagel 2018)	2.7	5.8	10.7	0.8	-2.9	-3.3	-0.6	-3.1	-2.7	-1.8
Angina	2.7	3.6	5.8	0.9	-2.3	-2.4	-1.6	-2.0	-2.0	-1.7
Taking other prescription medications	2.7	4.1	7.6	-0.6	-2.2	-2.8	-2.0	-2.7	-1.7	-1.2
Serious illness, injury or assault to yourself	2.7	3.3	6.4	-0.9	-2.1	-1.8	-2.5	-1.6	-1.1	-2.1
Weight	2.7	13.4	28.5	-1.1	-4.0	-5.0	-1.2	-5.3	-4.3	-1.9
Medication: Allopurinol	2.7	3.6	6.1	1.4	1.9	2.2	1.7	2.5	2.0	1.2
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	4.9	-0.3	2.1	2.2	1.1	1.9	1.0	2.2
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	6.8	0.7	1.7	1.9	1.7	2.0	2.6	1.8
Blood clot in the leg (DVT)	2.6	3.4	6.9	0.7	1.7	1.9	1.6	2.1	2.6	1.7
Chronotype (morning person)	2.5	5.7	15.1	3.9	2.3	1.8	2.5	2.4	1.4	1.6
Angina (self-reported)	2.5	3.2	5.2	1.1	-2.1	-2.3	-1.4	-1.9	-1.9	-1.5
Multivitamins +/- minerals	2.4	3.1	4.9	1.5	2.2	2.1	1.5	2.2	1.4	1.1
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.8	4.8	-2.1	-1.3	-1.8	-1.1	-2.2	-2.1	-0.7
Hypothyroidism (self reported)	2.3	5.3	8.4	-0.0	-2.6	-2.9	-2.5	-2.9	-2.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.7	6.7	-1.7	-1.9	-2.2	-1.4	-2.3	-2.6	-0.5
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	8.8	-0.2	-2.2	-2.7	-2.1	-3.0	-2.1	-0.5
Comparative body size at age 10	2.2	6.1	11.6	-0.5	3.0	2.6	2.1	1.9	2.5	3.4
Knee pain experienced in last month	2.2	3.4	8.3	-0.1	-2.1	-2.6	-0.3	-2.9	-1.7	-1.2
Average weekly champagne plus white wine intake	2.2	3.0	5.5	-1.1	1.6	1.9	2.0	1.6	2.3	1.4
Cholesterol lowering medication	2.2	3.2	4.0	2.0	-1.8	-1.9	-1.4	-1.5	-2.0	-1.8
HbA1C	2.1	2.3	4.5	1.1	2.1	1.5	1.8	1.2	1.2	1.5
Current tobacco smoking	2.0	3.2	5.7	-0.7	-2.2	-2.4	-1.9	-2.4	-1.2	-1.1
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	8.4	-2.9	-1.0	-0.9	-2.6	-1.4	-1.7	0.3
Average weekly beer plus cider intake	2.0	2.8	6.2	-2.2	-1.1	-1.8	-1.5	-2.5	-1.4	-0.0
Major Depression (MDD)	1.9	2.3	7.2	-0.9	-1.1	-1.3	-1.3	-1.4	-2.7	-1.2
Rheumatoid Arthritis	1.9	2.6	7.4	-2.7	-1.2	-1.1	-1.1	-1.7	-1.0	1.7
Hair/balding pattern: Pattern 2	1.9	2.5	6.1	-2.3	-1.1	-1.2	-2.5	-1.3	-1.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	4.1	0.9	1.5	1.7	0.8	1.3	2.0	1.9
Mother’s age at death	1.9	2.4	5.4	2.3	1.4	1.4	1.1	2.0	1.6	-0.2
Mean Putamen Volume	1.8	2.1	4.2	-1.3	-0.9	-1.5	-1.1	-1.9	-2.0	-1.0
Worrier / anxious feelings	1.8	3.5	9.2	3.0	1.6	1.3	1.9	2.2	1.4	0.7
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	40.2	-6.3	0.4	0.3	-0.6	0.0	1.0	1.2
Length of working week for main job	1.7	1.9	3.9	0.7	2.0	1.6	1.5	0.8	0.4	1.9
Wheeze or whistling in the chest in last year	1.7	3.1	5.8	0.0	-2.3	-2.4	-1.5	-2.4	-1.6	0.2
Smoking status: Current	1.7	2.7	4.6	-1.1	-2.0	-2.1	-1.8	-2.1	-1.0	-0.9
Number of treatments/medications taken	1.6	2.8	4.6	1.6	-2.0	-2.1	-1.1	-1.5	-1.6	-1.7
Medication: Atenolol	1.6	2.0	4.2	0.8	-1.6	-1.6	-1.1	-1.3	-1.0	-2.0
Medication: Simvastatin	1.6	2.4	4.2	-0.7	-1.7	-1.8	-1.3	-1.3	-2.0	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	33.1	-5.8	0.5	0.5	-0.3	0.2	1.0	1.0
Gout (self-reported)	1.6	2.2	3.7	0.5	1.7	1.7	1.6	1.9	1.4	1.0
Illnesses of siblings: Diabetes	1.6	1.9	3.7	-0.6	-1.8	-1.7	-0.9	-1.4	-1.9	-0.9
Schizophrenia vs Biploar Disorder	1.5	2.0	10.6	3.2	-0.5	-0.9	0.8	-1.1	0.0	-0.5
Alzheimer’s Disease (in father)	1.5	1.6	2.9	0.8	1.3	1.3	1.1	1.1	1.4	1.7
Maternal smoking around birth	1.5	2.2	5.9	-2.4	-0.6	-1.3	-0.1	-2.3	-1.1	0.7
Alcohol intake versus 10 years previously	1.5	2.2	3.8	1.0	-1.4	-1.7	-1.5	-1.9	-2.0	-0.3
Medication for cholesterol	1.5	2.3	13.5	-3.7	0.1	0.9	-1.2	0.6	0.0	0.3
Hearing aid user	1.5	1.6	4.1	2.0	1.3	1.0	1.2	1.0	1.0	1.1
Alcohol drinker status: Never	1.5	1.8	3.2	0.1	-1.6	-1.5	-1.7	-1.8	-1.0	-0.8
Ever depressed for a whole week	1.5	1.9	2.9	-1.6	-1.7	-1.4	-1.1	-1.5	-1.2	-0.9
Worry (Nagel 2018)	1.4	3.0	10.7	3.3	0.5	0.4	2.0	1.9	1.6	-0.1
HDL Cholesterol	1.4	2.3	3.6	1.8	1.6	1.7	0.9	1.9	1.6	0.8
Hand grip strength (left)	1.4	3.7	5.7	0.1	2.4	2.3	1.0	2.4	2.4	1.6
Alcohol intake frequency.	1.4	3.2	5.2	2.1	-2.1	-2.3	-0.7	-2.1	-1.8	-0.4
Mineral and other dietary supplements	1.4	1.9	7.1	2.7	-1.4	-1.1	-0.3	-1.3	-0.7	-0.6
Financial situation satisfaction	1.4	1.8	3.8	0.2	-1.5	-2.0	-0.9	-1.6	-1.6	-0.6
Risk taking	1.4	2.1	4.3	0.4	-1.5	-1.4	-0.6	-1.4	-2.0	-2.1
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.4	1.4	1.2	1.4	1.8	1.5	1.1	-0.1
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.9	2.2	-1.1	-0.9	-0.5	-0.4	-0.4	-1.5
Qualifications: CSEs or equivalent	1.3	1.8	4.1	-1.3	-1.0	-1.3	-0.8	-1.7	-2.0	0.5
Past tobacco smoking	1.3	2.4	4.8	2.2	1.5	1.4	1.1	1.5	1.8	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.9	0.5	-1.4	-2.0	-0.0	-1.9	-1.5	-1.3
Suffer from ‘nerves’	1.3	2.0	9.4	3.1	0.5	0.4	1.4	1.5	0.2	-0.4
Overall health rating	1.3	2.8	4.7	1.4	-2.0	-2.0	-0.9	-1.9	-2.2	-0.9
Medication: Lisinopril	1.3	1.7	3.2	1.8	-1.2	-1.7	-0.0	-1.4	-0.7	-1.5
Family relationship satisfaction	1.2	1.5	2.8	1.2	0.9	1.3	0.5	1.4	1.1	1.7
Smoking status: Previous	1.2	1.9	3.8	-2.0	-1.2	-1.1	-1.0	-1.1	-1.7	-1.3
Loneliness, isolation	1.2	1.6	2.8	1.5	-1.5	-1.4	-0.4	-1.1	-1.7	-0.5
Arm fat-free mass (left)	1.2	6.0	13.9	-1.2	-2.5	-3.4	-0.1	-3.7	-2.9	-0.7
Fractured/broken bones in last 5 years	1.2	1.5	2.8	0.5	-1.3	-1.3	-1.1	-0.8	-1.7	-1.4
Arm predicted mass (left)	1.2	6.2	14.3	-1.1	-2.5	-3.4	-0.1	-3.8	-3.1	-0.7
Waist Hip Ratio (WHR)	1.1	4.9	10.2	-1.5	-2.6	-3.2	-0.7	-2.9	-2.2	-1.1
Hand grip strength (right)	1.1	3.1	5.0	0.8	2.2	2.0	0.9	1.9	1.9	2.0
Forced vital capacity (FVC)	1.1	4.2	27.2	-5.2	0.2	-0.1	-0.6	-0.5	0.8	1.0
Medication: Ramipril	1.1	1.4	3.5	1.4	0.9	0.7	1.9	0.8	1.1	1.1
Medication: Cholesterol lowering	1.1	1.7	3.1	-0.9	-1.4	-1.4	-1.1	-1.3	-1.8	-1.1
Arm fat-free mass (right)	1.1	5.7	13.8	-1.0	-2.3	-3.3	0.0	-3.7	-3.0	-0.6
Arm predicted mass (right)	1.1	5.5	12.6	-1.0	-2.4	-3.3	-0.1	-3.5	-2.9	-0.7
Medication: Atorvastatin	1.1	1.4	5.1	2.3	-0.9	-0.8	-0.7	-0.4	-1.3	-1.0
Supplements: Calcium	1.1	1.2	6.4	-2.5	0.7	0.6	1.0	-0.1	0.3	0.5
Type 2 Diabetes (T2D) (2012)	1.0	1.1	4.0	0.3	-1.0	-1.6	-0.3	-2.0	0.0	-0.2
Lung FEV1/FVC ratio	1.0	5.0	27.0	-5.2	-1.4	-1.1	-1.8	-0.5	-0.6	-0.9
Lung FVC	1.0	4.9	31.7	-5.6	-0.1	0.1	-1.1	-0.3	0.5	1.0
Average weekly spirits intake	1.0	1.2	2.4	1.5	-0.4	-0.7	1.4	-1.5	-0.8	-0.5
Relative age of first facial hair	1.0	2.1	5.7	-0.0	-1.5	-1.8	-1.1	-2.4	-1.3	-0.8
Diabetes (father)	1.0	1.2	2.4	1.5	-1.0	-1.3	1.2	-0.8	-0.5	-1.2
Medication: Levothyroxine sodium	1.0	1.8	4.1	0.1	-1.5	-2.0	-0.8	-2.0	-1.1	-0.4
Depression (self-reported)	1.0	1.2	2.9	-0.6	-1.0	-1.3	-0.5	-0.8	-1.7	-1.3
Pulse wave Arterial Stiffness index	1.0	1.1	5.9	2.4	0.2	-0.3	1.0	-0.6	0.5	0.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.1	-0.5	-1.4	-1.4	0.1	-1.4	-1.2	-1.2
Number of full sisters	1.0	1.2	2.6	1.2	-0.3	-0.9	0.5	-1.6	-1.6	0.6
Number of self-reported non-cancer illnesses	1.0	1.7	5.1	2.3	-1.0	-1.5	-0.1	-1.3	-1.0	-0.8
Irritability	1.0	1.8	3.7	-1.1	-1.3	-1.6	-0.7	-1.9	-1.2	-1.1
Triglycerides	0.9	1.5	3.5	-0.8	-1.2	-1.4	-0.3	-1.9	-1.1	-1.4
Medication: Metformin	0.9	1.3	2.6	0.1	-1.2	-1.5	0.3	-1.5	-1.6	-0.8
High blood pressure (mother)	0.9	1.3	3.7	1.9	1.1	0.7	1.5	0.4	0.9	0.5
Nervous feelings	0.9	1.6	4.2	2.1	1.0	0.9	1.1	1.7	1.0	0.7
Diabetes (self-reported)	0.9	1.5	2.9	0.7	-1.5	-1.3	0.0	-0.9	-1.7	-1.5
Peak expiratory flow (PEF)	0.9	2.1	9.5	-3.1	0.6	0.6	0.9	0.4	1.1	1.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.2	0.3	-0.9	-1.2	0.7	-1.8	-1.3	-0.3
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.0	0.8	-0.8	-1.0	0.2	-1.7	-0.6	1.6
Forced vital capacity (FVC), Best measure	0.9	3.3	21.0	-4.6	0.5	0.4	-0.1	0.1	1.1	0.8
Pulse wave peak to peak time	0.9	1.1	6.1	-2.5	-0.2	0.3	-0.8	0.5	-0.5	-0.5
Shortness of breath walking on level ground	0.9	1.1	1.9	1.1	-1.3	-1.4	-0.2	-1.2	-0.9	-0.4
Medication for pain relief, constipation, heartburn	0.9	1.5	2.9	-1.4	1.3	1.2	0.6	0.9	1.7	1.0
Supplements: Vitamin C	0.9	1.1	2.0	-1.4	1.2	1.1	1.2	1.0	0.7	0.6
Diabetes diagnosed by doctor	0.9	1.5	2.9	0.9	-1.3	-1.3	0.1	-0.9	-1.7	-1.6
Asthma (self-reported)	0.9	1.7	4.8	1.3	-0.7	-1.3	0.8	-2.2	-0.7	1.5
Wears glasses or contact lenses	0.9	1.0	2.4	-0.9	-1.1	-0.8	-1.6	-0.9	-0.9	-0.5
Medication: Blood pressure	0.9	1.7	8.8	3.0	-0.5	-1.0	0.6	-0.7	-0.4	-0.9
Illnesses of father: High blood pressure	0.9	1.1	3.4	0.2	-1.5	-1.2	-0.4	-0.7	-0.2	-1.8
Basal metabolic rate	0.9	4.8	12.4	-0.9	-2.0	-3.0	0.4	-3.5	-2.6	-0.5
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.2	0.5	1.2	1.2	1.5	1.1	0.9	-0.2
Neuroticism (Nagel 2018)	0.8	2.0	3.3	1.7	-1.7	-1.8	0.3	-1.0	-1.2	-1.5
Crohns Disease (2017)	0.8	1.7	3.8	0.1	1.2	1.6	1.2	2.0	1.2	1.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.0	-1.4	-1.0	-0.9	-1.0	-1.2	-0.9	-0.3
Mouth/teeth dental problems	0.8	1.2	2.1	1.1	1.0	1.1	0.7	1.1	1.2	1.4
Asthma	0.8	1.6	3.6	1.5	-0.5	-1.1	1.1	-1.9	-0.4	1.6
Medication: Paracetamol	0.8	1.4	3.5	0.8	-1.0	-1.3	-0.0	-1.6	-1.9	-0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.5	0.3	1.3	1.5	0.9	1.0	0.8	1.6
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.4	1.0	-0.6	-1.1	0.4	-1.6	-1.2	-0.1
Exposure to tobacco smoke outside home	0.8	1.1	4.3	2.1	0.4	0.7	0.2	1.1	1.1	0.2
Eye problems/disorders: None of the above	0.8	1.0	5.8	-2.4	0.2	0.4	-0.2	0.3	-0.4	0.7
Heart disease (mother)	0.8	0.9	2.2	1.4	0.7	0.5	1.5	1.0	0.6	-0.4
Mood swings	0.8	1.5	3.2	0.4	-1.1	-1.8	0.2	-1.8	-1.5	-0.3
Medication: Aspirin	0.8	1.0	1.8	0.8	-1.2	-1.4	-0.7	-0.6	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	10.8	-3.3	0.5	0.3	-0.3	-0.2	0.6	0.2
Medication: Paracetamol	0.8	1.2	2.4	1.1	-1.0	-1.2	0.1	-1.1	-1.6	-0.8
Myopia	0.8	1.2	1.8	-0.6	1.0	1.3	1.0	1.3	1.3	0.8
Ulcerative Colitis (UC)	0.7	1.4	3.1	0.4	-1.8	-1.6	-1.0	-0.8	-1.5	-0.3
Reaction Time	0.7	1.2	5.3	1.7	0.3	0.2	2.3	-0.1	0.3	0.3
Bipolar Disorder (2011)	0.7	0.7	2.3	-0.7	-0.8	-0.3	-1.5	0.2	0.0	-1.1
Fasting Glucose	0.7	0.8	3.0	-0.1	-0.5	-0.8	-0.1	-1.0	-1.7	-0.9
Type 2 Diabetes (T2D) (2018)	0.7	1.4	2.5	0.2	-1.2	-1.6	0.5	-1.3	-1.5	-1.2
Medication for hormone replacement therapy	0.7	0.7	2.1	0.8	1.1	0.5	1.5	0.2	0.5	0.8
Vitamin and mineral supplements	0.7	1.0	2.0	0.1	-1.4	-1.2	-1.0	-1.4	-0.6	-0.4
Medication: Co-codamol	0.7	0.9	1.5	-0.6	-1.1	-1.0	-1.1	-0.3	-1.2	-0.7
Leg fat-free mass (left)	0.7	3.8	10.8	-0.5	-1.7	-2.7	0.5	-3.3	-2.2	-0.4
Sitting height	0.7	5.0	9.2	1.4	2.7	2.2	3.0	1.6	2.3	2.0
Leg predicted mass (left)	0.7	3.8	10.7	-0.5	-1.7	-2.7	0.5	-3.3	-2.2	-0.4
Pain all over the body in last month	0.7	0.8	1.8	0.8	-1.1	-1.3	0.2	-1.1	-0.7	-0.4
Number of live births	0.7	1.0	2.2	1.5	1.1	1.0	0.9	0.3	0.1	1.1
Loud music exposure frequency	0.7	0.8	2.4	0.6	1.1	0.4	1.6	-0.6	0.3	0.9
Mean time to correctly identify matches	0.7	1.3	4.8	1.9	0.7	0.5	2.2	0.2	0.1	0.3
Ever taken oral contraceptive pill	0.7	0.7	2.5	-0.3	-0.9	-0.7	-1.6	0.1	-0.1	-1.2
Schizophrenia (2018)	0.6	1.2	2.8	0.3	-1.3	-1.5	0.9	-1.7	0.0	-0.9
Ovarian Cancer	0.6	0.9	1.9	-1.4	0.2	0.5	-1.1	1.3	0.5	-0.8
Respiratory disease	0.6	1.2	3.1	1.8	-0.7	-1.0	0.7	-1.4	-0.2	1.2
Relative age voice broke	0.6	0.9	1.9	-1.1	-1.0	-1.2	-0.6	-1.4	-0.5	-0.4
Time employed in main current job	0.6	0.7	1.4	0.2	0.7	0.8	1.1	0.9	1.2	0.3
Falls in the last year	0.6	0.8	1.7	1.0	0.8	0.5	1.3	-0.3	0.4	1.3
Mouth/teeth dental problems: Dentures	0.6	1.0	4.1	2.0	-0.1	-0.4	0.2	-0.2	-0.2	-1.7
Prospective memory result	0.6	0.8	1.5	0.7	-0.9	-1.2	-0.5	-0.9	-0.4	-1.2
Impedance of arm (left)	0.6	2.8	6.4	-0.1	1.7	2.2	0.2	2.3	2.5	0.1
Exposure to tobacco smoke at home	0.6	0.7	1.7	0.2	-0.8	-0.9	-0.7	-1.3	-0.8	-0.6
Glaucoma (self-reported)	0.6	0.7	2.5	0.2	-0.7	-1.0	-0.7	-1.6	-0.3	-0.7
Birth weight	0.6	1.3	2.1	-1.2	-1.1	-1.2	-1.4	-1.4	-0.8	-0.4
Mouth/teeth dental problems: Loose teeth	0.6	0.8	3.0	-1.7	0.4	0.5	0.4	0.1	1.1	0.7
Long-standing illness, disability or infirmity	0.6	0.9	1.8	1.0	-1.1	-1.3	-0.3	-0.8	-0.8	-1.2
Medication: Gliclazide	0.6	0.7	2.5	0.4	-0.4	-0.6	1.6	-0.2	-0.8	-1.0
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.2	0.4	-1.0	-0.9	-1.1	-0.9	-0.8	-0.8
Heart disease (siblings)	0.6	0.7	1.7	-0.0	-1.1	-1.3	-0.3	-1.3	-0.4	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.8	2.3	0.7	1.2	1.5	0.2	0.7	0.0	0.8
Crohns Disease (2012)	0.5	0.8	2.4	-0.9	0.9	1.2	0.5	1.6	0.0	0.4
Schizophrenia (2014)	0.5	1.1	1.9	0.6	-1.3	-1.4	1.0	-1.3	0.0	-1.1
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.3	-0.7	-0.6	-0.8	-0.2	-1.1	-1.5	0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	1.2	-0.4	-0.7	0.9	-0.5	-0.8	-0.7
Pack years adult smoking proportion	0.5	0.7	3.8	1.9	-0.5	-0.3	-0.7	0.2	0.2	-0.6
Supplements: Glucosamine	0.5	0.7	4.2	-2.0	0.2	0.3	0.3	0.6	-0.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	1.1	-0.7	-0.9	-0.2	-0.6	-0.9	-0.6
Number of incorrect matches in round	0.5	0.9	1.7	-0.0	1.2	1.1	-0.2	0.8	0.9	1.3
Impedance of arm (right)	0.5	2.4	5.4	-0.4	1.4	2.0	-0.1	2.3	2.3	-0.2
Happiness	0.5	0.6	1.8	0.4	0.8	0.9	0.3	1.4	0.6	0.8
Illnesses of mother	0.5	0.6	2.6	-1.6	0.0	0.4	-1.0	0.2	-0.3	0.3
Medication: Amlodipine	0.5	0.6	1.8	1.2	-0.4	0.2	-0.8	0.5	-0.1	-1.3
Medication: Omeprazole	0.5	0.6	2.0	-0.1	-1.0	-0.9	-1.4	-0.2	-0.1	-0.2
Chest pain or discomfort	0.5	0.7	1.4	0.9	-1.1	-1.2	0.3	-0.7	-0.7	-0.8
Whole body fat-free mass	0.5	3.0	8.2	-0.8	-1.4	-2.4	0.8	-2.9	-2.1	-0.1
Leg fat-free mass (right)	0.5	2.9	8.9	-0.0	-1.4	-2.4	0.6	-3.0	-1.9	-0.2
Back pain experienced in last month	0.5	0.7	2.0	-0.2	-0.5	-0.5	-1.2	-0.3	-1.4	-0.9
Whole body water mass	0.5	3.0	8.0	-0.8	-1.4	-2.4	0.7	-2.8	-2.0	-0.1
Leg predicted mass (right)	0.5	2.8	8.5	0.0	-1.4	-2.3	0.7	-2.9	-1.9	-0.2
High cholesterol (Self-reported)	0.5	1.0	1.9	0.2	-1.4	-1.3	-0.3	-1.3	-1.0	-0.7
Medication: Bendroflumethiazide	0.5	0.8	2.5	1.6	-0.9	-0.8	-0.1	-0.3	-0.1	-1.3
Commuting to job workplace: Cycle	0.5	0.6	1.8	0.5	1.3	0.9	0.9	0.1	0.4	0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	2.1	-0.7	-1.3	-1.4	0.4	-1.4	0.0	-0.8
Depression (Nagel 2018)	0.4	0.6	1.5	0.3	-0.6	-0.9	-0.3	-1.1	-1.2	0.5
Body Mass Index (BMI) (2010)	0.4	0.6	1.5	-0.6	-0.4	-0.8	0.3	-1.2	-1.2	-0.1
Heel T-Score	0.4	2.9	5.8	1.6	2.4	1.8	1.1	1.2	2.4	0.1
Sensitivity / hurt feelings	0.4	0.6	1.6	1.3	0.4	0.5	0.7	1.1	0.8	0.1
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	0.5	-0.7	-0.8	0.5	-0.8	-1.0	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.6	0.3	0.2	-0.2	-0.4	-0.7	-1.0	1.3
Stomach or abdominal pain in last month	0.4	0.5	2.4	1.5	0.3	-0.1	0.9	-0.7	-0.0	0.0
Hearing difficulty/problems with background noise	0.4	0.7	1.6	0.9	0.4	0.2	1.3	-0.5	-0.5	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.2	1.5	1.1	0.6	0.8	0.3	1.2	-0.0
Allergy	0.4	1.0	4.7	-2.2	0.3	0.3	-1.2	0.6	0.3	-0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.2	0.5	-1.1	-0.7	-0.6	-0.6	-1.0	-0.2
Neuroticism score	0.4	0.8	4.1	2.0	0.1	-0.3	1.1	0.2	-0.2	0.2
High blood pressure (siblings)	0.4	0.5	1.0	0.7	0.7	0.6	0.7	0.9	1.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.7	0.4	0.8	0.7	0.9	0.9	0.2	0.8
Migraine (self-reported)	0.4	0.5	2.1	0.5	-0.8	-0.3	-1.5	0.1	0.7	-0.0
Medication: Seretide 50 evohaler	0.4	0.4	1.6	0.5	-0.0	-0.1	0.7	0.0	0.9	1.3
Comparative height size at age 10	0.4	2.0	4.2	0.3	2.0	1.3	1.6	1.1	0.6	2.1
Medication: Aspirin	0.4	0.5	1.3	1.1	-0.7	-0.8	-0.7	-0.2	-0.7	-0.6
Hypertension (Self-reported)	0.4	1.0	5.3	2.3	0.4	-0.1	1.0	0.5	0.3	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.9	0.5	-0.8	-0.8	1.0	-0.5	-0.6	-0.4
Ever had bowel cancer screening	0.4	0.5	2.0	0.2	0.0	0.4	-0.6	1.0	-0.0	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	3.2	1.8	0.2	0.4	-0.2	0.2	0.3	-0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	2.0	-1.4	0.5	0.0	0.4	-0.5	-0.6	0.5
Ever smoked	0.4	0.6	1.1	-1.0	-0.9	-0.9	-0.4	-0.8	-0.9	-0.5
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	0.4	0.7	0.5	0.8	0.7	0.9	0.6
Alcohol drinker status: Previous	0.4	0.4	1.5	0.2	-0.0	-0.7	0.0	-1.2	-0.7	0.6
Pack years of smoking	0.4	0.6	4.1	2.0	-0.2	-0.1	-0.4	0.3	0.2	-0.4
Prostate Cancer	0.3	0.4	0.9	0.1	-0.5	-0.5	-0.8	0.1	-1.0	-0.6
LDL Cholesterol	0.3	0.5	1.6	0.6	-0.8	-0.7	-1.3	-0.2	0.2	-0.8
Lupus	0.3	0.4	1.7	-1.3	0.0	-0.3	-0.1	-0.9	0.2	0.7
Neuroticism (2016)	0.3	0.4	0.9	0.4	-0.4	-1.0	-0.6	-0.9	0.0	-0.7
Primary Biliary Cirrhosis	0.3	0.5	1.7	-0.7	-0.0	-0.0	-1.3	0.2	-0.6	0.9
Blood Red Count	0.3	3.3	6.6	-1.6	-2.1	-1.9	-2.6	-1.5	-1.8	0.8
Blood White Count	0.3	2.6	4.3	-1.1	-1.9	-1.8	-1.4	-2.1	-1.6	-1.1
Systolic Blood Pressure	0.3	1.3	5.2	-0.0	-1.1	-0.7	-2.3	-0.1	-0.7	-1.2
Allergy or Eczema	0.3	0.7	3.1	1.8	-0.3	-0.3	0.9	0.2	-0.2	-0.8
Cardiovascular Disease	0.3	1.1	2.5	1.6	-1.0	-1.5	0.1	-1.2	-0.5	-0.6
Neuroticism	0.3	0.8	2.7	1.6	-0.7	-1.1	0.6	-0.3	-0.5	-0.9
Hearing difficulty/problems: Yes	0.3	0.4	1.0	1.0	-0.0	-0.2	0.8	-0.7	-0.6	0.5
Diabetes (mother)	0.3	0.4	1.1	0.5	-0.5	-1.0	0.4	-1.0	-0.3	-0.2
Severe depression (siblings)	0.3	0.3	0.9	0.9	-0.0	-0.4	1.0	0.1	-0.2	-0.5
Average weekly fortified wine intake	0.3	0.4	1.4	-0.1	-0.1	-0.7	1.2	-0.5	0.5	0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.8	1.3	-0.4	-0.4	-0.1	0.2	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.9	1.4	0.8	0.6	0.1	0.4	1.3	0.1
High blood pressure	0.3	1.0	5.7	2.4	0.4	-0.0	0.7	0.3	0.2	-0.3
Had menopause	0.3	0.4	1.6	0.2	-0.2	0.2	-1.3	0.1	-0.9	-0.1
Illnesses of siblings	0.3	0.5	1.1	0.2	0.8	1.1	0.4	0.6	0.6	0.7
Trunk fat-free mass	0.3	1.7	3.8	-1.1	-0.6	-1.5	1.4	-2.0	-1.4	0.5
Trunk predicted mass	0.3	1.6	3.8	-1.0	-0.6	-1.4	1.4	-1.9	-1.4	0.6
Breastfed as a baby	0.3	0.4	1.2	-0.5	0.4	0.4	-1.1	-0.1	-0.5	0.9
Tense / ‘highly strung’	0.3	0.4	1.2	0.7	-0.4	-0.7	1.1	-0.5	-0.7	-0.3
Number of children fathered	0.3	0.3	1.2	0.0	0.5	0.6	-0.3	0.3	-0.1	1.1
Health satisfaction	0.3	0.3	0.6	0.5	-0.8	-0.8	0.2	-0.4	-0.8	-0.3
Medication: Blood pressure	0.3	0.5	0.8	0.4	-0.8	-0.8	-0.9	-0.6	-0.2	-0.9
Pulse rate, automated reading	0.3	1.1	1.4	1.2	-1.0	-1.1	1.1	-1.2	-1.1	-0.6
Had major operations	0.3	0.3	0.7	-0.7	0.8	0.5	0.4	0.3	0.3	0.8
Osteoarthritis (self-reported)	0.3	0.4	1.2	1.1	-0.0	-0.6	0.1	-0.7	-0.3	-0.6
Miserableness	0.3	0.5	1.1	-0.2	-1.0	-1.0	0.2	-0.9	-0.5	-0.5
Eye problems/disorders: Glaucoma	0.3	0.4	1.4	1.0	0.3	-0.3	-0.3	-1.2	0.1	-0.1
Number of operations (self-reported)	0.3	0.4	0.8	0.8	-0.2	-0.5	0.7	-0.9	-0.7	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.3	-1.8	0.4	1.0	0.1	0.7	0.8	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.1	0.9	-0.7	-0.4	-1.1	0.1	0.5	0.1
Pain experienced in last month	0.3	0.6	1.4	-0.2	0.9	0.9	0.2	1.2	0.8	0.5
Bipolar Disorder (2018)	0.2	0.4	2.0	-1.4	-0.5	-0.4	-0.5	-0.3	0.0	-0.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.2	0.4	0.7	-0.3	0.5	-0.2	-0.4
Impedance of leg (right)	0.2	1.2	3.4	-1.8	-0.6	0.0	-1.7	0.7	0.2	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	1.3	-0.7	-0.5	0.5	-0.3	-0.8	-0.6
Impedance of leg (left)	0.2	1.1	4.1	-1.2	-0.8	-0.1	-2.0	0.6	0.2	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	0.9	-0.1	-0.2	0.6	-0.3	-0.8	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.2	-0.2	-0.3	0.6	-0.4	-0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.4	-0.4	0.2	0.3	0.9	-0.4	-0.8
Medication: Lansoprazole	0.2	0.3	0.8	0.9	0.4	0.4	0.5	0.6	0.3	-0.2
Lung cancer (father)	0.2	0.2	0.7	-0.8	-0.4	0.1	-0.8	0.1	-0.5	0.1
Pulse wave reflection index	0.2	0.3	1.7	1.3	0.1	-0.1	-0.3	-0.3	0.2	0.1
Headache pain in last month	0.2	0.4	1.6	-0.2	-0.0	0.1	0.8	0.1	0.3	1.3
Worry too long after embarrassment	0.2	0.4	0.8	0.6	0.9	0.6	0.8	0.3	-0.1	0.3
Neck or shoulder pain in last month	0.2	0.2	0.7	0.8	-0.7	0.1	-0.3	0.0	-0.3	-0.6
Medication: Ibuprofen	0.2	0.2	0.6	-0.3	-0.2	0.1	0.8	0.6	-0.2	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.1	0.8	0.1	0.4	-1.0	0.3	0.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.5	0.5	0.2	0.4	0.2	0.8	1.2	0.3
Osteoporosis (self-reported)	0.2	0.3	1.0	0.2	0.4	0.6	1.0	0.7	-0.2	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	-0.0	-0.4	-0.6	0.6	-0.7	-0.3	0.6
Diastolic blood pressure, automated reading	0.2	0.6	3.2	1.8	0.2	0.5	0.0	0.9	0.4	-0.0
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.2	0.7	0.6	0.3	0.5	-0.0	0.8
Impedance of whole body	0.2	1.2	2.9	-0.7	0.5	1.1	-1.0	1.6	1.7	-0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.2	-0.4	-0.1	-0.0	0.6	-0.5	0.5
Breast Cancer	0.1	0.3	1.3	0.4	-0.1	-0.3	0.5	-1.1	0.0	0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.3	-0.3	-0.2	-0.5	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.2	0.5	-0.2	-0.7	-0.4	-0.6	0.0	0.0	0.5
Blood Eosinophil Count	0.1	1.0	4.2	0.7	1.0	0.8	0.8	0.1	0.4	2.0
Blood Platelet Count	0.1	1.5	4.5	1.8	-1.1	-1.0	-0.3	-0.5	-0.4	-2.1
Height	0.1	1.4	5.2	-2.3	0.9	0.1	1.3	-1.1	-0.1	0.9
Hair Pigment	0.1	3.5	6.8	-0.8	-1.8	-2.3	-1.2	-2.6	-2.5	-0.8
Tanning	0.1	0.8	1.3	-1.0	-1.1	-0.7	-0.8	-1.2	-0.9	-0.4
Systolic blood pressure, automated reading	0.1	0.4	0.9	0.9	-0.7	-0.4	-0.7	0.2	-0.3	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.3	0.5	0.5	-0.2	0.6	-0.1	-0.4	0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	0.6	0.2	0.5	-0.2	0.1	0.1	-0.5
Had other major operations	0.1	0.1	0.5	-0.7	-0.5	-0.2	0.2	-0.4	-0.1	-0.0
Pulse rate	0.1	0.3	0.8	0.9	-0.3	-0.3	0.6	-0.4	-0.0	-0.3
Standing height	0.1	1.2	2.8	-1.2	1.2	0.7	1.7	0.4	0.8	1.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.7	-0.8	0.1	0.2	0.0	0.5	0.5	-0.4
Birth weight of first child	0.1	0.1	0.5	0.7	0.2	0.3	0.1	0.4	0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.2	0.2	0.1	0.6	-0.5	0.4	-0.2
Emphysema/chronic bronchitis	0.1	0.2	0.8	0.0	-0.4	-0.2	-0.3	0.2	0.9	-0.0
Breast cancer (self-reported)	0.1	0.1	0.4	-0.1	-0.3	-0.2	-0.6	-0.5	0.2	-0.1

Hub : Genes

LONRF2

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