Hub : Genes

AFF3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3100	0.0530	0.0e+00	0.237	0.197	0.254	0.247	0.251	1.6e-28	2.0e-23	9.2e-31	9.8e-30	2.7e-30
2	GTEx	Artery Aorta	0.1400	0.0490	1.8e-04	0.058	NA	0.042	NA	0.069	4.1e-04	NA	2.4e-03	NA	1.2e-04
3	GTEx	Artery Tibial	0.0557	0.0252	5.8e-03	0.044	NA	0.040	NA	0.027	2.2e-04	NA	4.3e-04	NA	3.0e-03
4	GTEx	Brain Nucleus accumbens basal ganglia	0.2950	0.1120	2.3e-03	-0.001	NA	-0.008	NA	0.010	3.5e-01	NA	5.8e-01	NA	1.7e-01
5	GTEx	Skin Not Sun Exposed Suprapubic	0.2210	0.0840	4.0e-03	0.018	NA	0.022	NA	-0.001	3.5e-02	NA	2.2e-02	NA	3.6e-01
6	GTEx	Skin Sun Exposed Lower leg	0.0770	0.0370	7.6e-03	0.016	NA	0.017	NA	0.025	1.6e-02	NA	1.5e-02	NA	3.5e-03
7	GTEx	Spleen	0.3880	0.1300	3.2e-03	-0.011	NA	-0.008	NA	-0.010	8.5e-01	NA	6.0e-01	NA	7.1e-01
8	NTR	Blood	0.0290	0.0121	1.6e-03	0.006	0.006	0.003	0.006	0.005	4.7e-03	4.0e-03	3.2e-02	4.1e-03	6.6e-03
9	ROSMAP	Brain Pre-frontal Cortex	0.3066	0.0558	0.0e+00	0.239	0.198	0.252	0.248	0.246	2.0e-30	6.8e-25	3.5e-32	1.5e-31	2.9e-31
10	YFS	Blood	0.0600	0.0162	7.6e-13	0.037	0.048	0.057	0.052	0.056	4.0e-12	2.8e-15	6.2e-18	1.5e-16	8.2e-18
11	TCGA	Brain Lower Grade Glioma	0.0276	0.0141	5.5e-03	0.014	0.015	0.011	NA	0.012	9.2e-03	6.6e-03	2.0e-02	NA	1.4e-02
12	TCGA	Liver Hepatocellular Carcinoma	0.1130	0.0500	1.2e-03	0.010	0.029	-0.001	NA	0.013	1.0e-01	1.6e-02	3.7e-01	NA	7.7e-02
13	TCGA	Prostate Adenocarcinoma	0.0634	0.0289	2.7e-03	-0.002	0.013	0.000	NA	-0.002	8.1e-01	1.4e-02	3.2e-01	NA	7.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	1.6	2.5	9.4	1.1	-0.2	0.3	2.6	0.5	0.6	3.1	0.9	1.3	1.2	1.7	2.8	-0.2
Bipolar Disorder or Schizophrenia	0.7	1.6	8.4	0.5	0.1	0.1	2.1	1.4	1.0	2.9	0.2	0.3	0.7	0.7	1.5	-1.2
Depressed Affect (Nagel 2018)	0.6	1.2	7.3	-1.1	-1.1	-1.1	0.2	2.7	0.1	-0.9	-1.5	-0.8	-0.5	-0.6	-0.3	-0.9
Depression (Nagel 2018)	0.3	0.4	1.4	-0.9	-1.2	-0.0	0.2	0.8	-0.0	0.4	-0.6	-0.3	-0.1	0.3	0.4	-1.1
Intelligence (Savage-Jansen 2018)	6.4	19.8	44.2	6.6	6.2	6.1	0.0	-4.3	-0.4	-2.2	-0.3	6.0	-2.9	5.4	3.2	5.6
Neuroticism (Nagel 2018)	1.0	2.3	9.1	1.4	1.6	1.3	1.0	2.4	-0.1	-1.2	-3.0	1.3	-1.6	0.8	0.9	0.3
Schizophrenia (2018)	0.3	0.6	2.3	-0.3	0.2	-0.1	0.6	1.5	1.0	1.3	-0.5	-0.7	-0.1	-0.4	-0.3	-1.5
Schizophrenia vs Biploar Disorder	2.6	3.4	12.6	-0.1	0.5	0.4	0.4	2.9	2.5	-0.6	-2.0	-0.5	-1.9	-2.8	-3.5	0.4
Worry (Nagel 2018)	2.4	5.1	21.8	2.2	4.7	3.0	2.2	1.4	1.0	-0.9	-2.9	1.9	-2.3	0.2	-0.4	2.2
Alzheimer’s Disease (in mother)	1.3	1.5	4.4	1.3	1.2	2.1	1.5	-1.1	-0.2	-0.0	-1.1	1.6	-0.2	1.8	1.1	-0.1
Alzheimer’s Disease (in father)	1.0	1.1	3.5	-1.4	-0.5	-0.7	-1.0	-0.3	0.9	1.9	1.1	-0.6	0.3	-1.6	-1.5	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	1.6	-0.1	-0.3	0.5	-0.1	-1.3	-0.4	0.2	-0.4	0.4	-0.0	0.2	-0.3	-0.3
Crohns Disease (2017)	0.3	0.7	3.6	0.0	1.4	0.3	0.0	-1.9	-0.6	0.8	-0.1	0.6	-1.0	0.6	0.4	0.7
Irritable Bowel Disease (IBD)	0.7	1.6	4.0	-2.0	0.4	-1.9	-0.3	-0.4	-0.5	1.6	1.7	-1.1	0.9	-1.8	-1.3	0.2
Ulcerative Colitis (UC)	1.9	3.5	8.2	-2.6	-0.3	-2.5	-0.5	1.4	-0.2	2.0	2.2	-1.7	2.2	-2.9	-2.2	0.3
Major Depression (MDD)	1.9	2.3	6.1	-1.7	-1.3	-1.8	-0.8	1.5	-0.4	1.7	0.8	-1.6	2.3	-1.0	1.0	-2.5
Reaction Time	0.5	1.0	3.3	-1.2	0.3	-0.0	-0.1	1.0	0.5	-1.3	-1.0	-1.8	-1.4	-1.2	-1.2	-0.2
Verbal and Numeric Reasoning (VNR)	6.2	14.8	32.4	5.7	5.0	5.4	-0.1	-3.9	-0.8	-1.6	-0.5	5.0	-2.9	4.3	2.3	5.5
Breast Cancer	0.5	1.3	4.1	-1.3	-2.0	-1.0	-0.2	-0.5	-0.3	-1.1	-1.6	-1.5	-0.8	-1.0	0.0	-1.3
Ovarian Cancer	0.8	1.0	4.3	1.2	2.1	1.1	-0.9	-1.3	-0.1	0.5	0.2	1.2	-0.5	1.1	0.8	-0.3
Prostate Cancer	2.1	3.0	7.3	-2.0	-0.7	-2.5	-0.6	1.0	1.1	1.6	1.9	-1.6	2.0	-2.7	-0.9	-2.2
Age at First Birth	6.8	9.9	34.1	3.6	4.3	5.8	0.5	-0.0	-0.1	-0.5	-3.5	3.5	-4.3	3.0	1.4	3.1
Bipolar Disorder (2011)	1.2	1.2	5.5	0.1	0.3	0.1	0.4	0.3	-2.1	1.1	0.3	0.6	0.2	1.7	2.4	0.9
Body Mass Index (BMI) (2010)	0.8	1.1	4.8	-1.6	-2.2	-1.1	-0.9	-0.4	-0.4	-0.7	-0.6	-1.5	-0.2	-0.5	-0.9	-0.6
Coronary Artery Disease (CAD)	0.8	1.0	3.0	-0.5	0.2	-0.5	1.7	1.0	0.8	1.7	0.8	0.1	0.8	-1.5	-1.1	0.5
Crohns Disease (2012)	0.7	1.1	3.2	0.6	1.2	0.4	0.1	-1.8	-0.5	1.3	0.6	1.3	-0.2	1.3	1.6	0.6
Mean Putamen Volume	0.9	1.1	5.0	-0.6	-1.4	-1.3	-2.2	0.3	0.6	0.1	0.7	-0.5	0.6	-0.3	0.1	-1.8
Fasting Glucose	1.5	1.8	4.7	-1.1	-1.0	-2.2	0.3	2.1	2.0	-0.3	1.0	-1.0	1.4	-1.6	-1.1	-0.6
HbA1C	0.5	0.6	3.4	-0.3	0.0	-0.7	0.2	-0.8	0.8	-0.5	0.0	-0.1	0.3	-1.0	-1.8	0.8
HDL Cholesterol	0.6	1.1	3.9	1.1	1.1	2.0	0.0	-0.1	-1.5	0.1	-0.1	0.9	-1.2	1.1	1.0	0.9
LDL Cholesterol	0.1	0.2	0.6	0.1	0.0	-0.1	-0.2	-0.2	-0.2	-0.7	0.1	0.2	-0.8	-0.4	-0.8	-0.0
Lupus	0.6	0.8	2.3	-1.0	-1.5	-1.3	-0.2	-0.9	-0.6	-0.8	0.5	-0.8	0.9	-0.1	1.1	-1.1
Neuroticism (2016)	0.9	1.4	3.4	1.2	0.5	1.7	1.0	0.3	-0.8	-0.0	-1.1	1.5	-0.7	1.8	1.8	0.7
Primary Biliary Cirrhosis	1.1	1.6	4.6	-1.3	-0.6	-1.8	0.4	-0.0	0.9	1.3	1.9	-0.2	2.1	-2.0	-0.7	-0.1
Rheumatoid Arthritis	6.9	9.4	30.2	-3.5	-3.3	-4.5	0.3	0.6	1.4	3.0	4.3	-2.1	5.5	-3.3	-1.0	-1.8
Schizophrenia (2014)	0.4	0.8	4.8	0.2	0.6	0.1	1.1	2.2	0.7	1.5	-0.7	-0.1	-0.1	-0.4	0.3	-0.8
Triglycerides	0.3	0.4	1.7	0.0	0.0	-0.3	0.3	0.6	1.3	-0.1	-1.3	-0.4	-0.9	-0.1	0.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.8	-0.6	-1.7	-0.7	0.3	0.8	0.6	0.3	-0.7	-0.9	-0.5	-0.2	-0.9	0.5
Ulcerative Colitis	2.2	3.1	10.5	-1.7	1.1	-2.6	-0.3	1.7	-0.7	1.5	2.8	-0.8	3.2	-2.1	-0.9	0.2
Blood Eosinophil Count	0.5	3.8	10.0	-2.5	-2.2	-3.2	-2.4	-0.5	-2.0	-0.9	2.5	-2.0	0.9	-2.2	-1.5	-0.1
Blood Platelet Count	0.3	3.2	10.7	0.8	0.2	2.6	0.0	0.9	0.2	0.1	-1.9	0.7	-3.3	2.7	3.3	-0.2
Blood Red Count	3.2	31.1	83.6	-7.3	-4.7	-9.1	1.2	1.2	2.1	2.2	5.6	-5.1	7.2	-9.0	-4.9	-4.2
Blood White Count	0.3	2.2	8.7	-1.9	-2.0	-0.6	1.2	0.6	0.5	2.0	0.5	-1.9	0.4	0.0	1.1	-3.0
Heel T-Score	0.7	5.7	13.8	2.1	2.4	3.7	1.0	0.6	-0.9	-1.3	-3.0	-0.2	-3.6	3.0	3.4	-1.7
BMI	2.9	16.8	76.9	-5.4	-8.8	-5.3	0.6	0.8	-1.8	-1.0	-4.3	-5.8	-1.5	-2.6	-1.7	-3.9
Height	0.5	9.3	33.9	3.3	-0.4	3.0	-2.5	-3.8	-2.7	-2.8	-2.4	3.1	-1.8	5.8	3.3	1.7
Waist Hip Ratio (WHR)	2.8	12.8	51.4	-3.5	-2.1	-2.6	1.2	1.5	7.2	2.1	1.3	-3.8	1.7	-4.8	-6.3	-1.5
Systolic Blood Pressure	1.1	5.5	13.5	-2.5	0.2	-2.1	0.1	2.3	3.2	2.4	2.8	-1.8	2.7	-3.7	-2.0	-1.8
Smoking Status	1.9	4.4	13.4	0.0	-2.4	-0.6	3.7	2.0	2.4	3.3	0.2	0.4	1.5	0.7	1.4	-3.5
Allergy or Eczema	0.9	2.4	7.6	-0.4	1.3	-0.1	2.2	1.1	2.8	-0.9	-1.2	-0.5	-0.7	-2.4	-2.7	0.2
Cardiovascular Disease	0.8	2.7	8.0	-0.8	-0.4	-1.0	1.6	2.4	2.2	0.7	-2.2	-1.7	-0.3	-2.8	-0.8	-1.9
Hypothyroidism (self reported)	2.7	6.1	20.2	-3.7	-2.9	-4.5	-1.2	0.9	-1.1	1.9	1.3	-3.5	1.8	-2.8	-1.0	-2.1
Respiratory disease	2.4	5.4	15.4	-3.2	-3.1	-3.3	-2.2	0.9	-0.8	-1.1	0.4	-3.2	1.4	-3.9	-1.9	-0.9
Type 2 Diabetes (T2D) (2018)	1.5	2.9	9.4	-2.4	-1.4	-1.8	-0.2	0.5	2.4	1.1	-0.4	-3.1	-0.2	-2.5	-1.1	-1.3
Lung FEV1/FVC ratio	1.1	5.7	19.7	-1.7	-1.3	-2.2	3.5	-2.2	1.1	2.0	2.7	-1.7	2.7	0.6	2.0	-4.4
Lung FVC	1.0	5.3	19.8	2.1	1.3	-0.8	-0.1	-1.9	-2.1	2.2	3.0	2.7	4.5	2.0	3.1	0.2
Neuroticism	0.6	1.6	8.9	0.9	1.2	1.2	1.4	1.3	0.4	-0.6	-3.0	0.9	-1.4	0.4	1.0	0.2
Chronotype (morning person)	0.8	1.8	7.2	-0.6	1.8	1.3	-0.1	-1.3	-0.1	-0.9	-1.3	-0.5	-2.7	-1.1	-1.9	0.9
Hair Pigment	0.1	1.4	5.2	-1.0	-1.6	-1.0	1.7	1.0	0.5	0.8	-0.6	-0.7	0.7	-1.2	-1.2	-2.3
Tanning	0.1	0.7	4.8	-0.4	-2.2	-0.8	-0.3	0.9	-0.2	-0.2	0.9	0.1	1.1	-0.1	0.3	-0.6
Hand grip strength (left)	2.1	5.6	19.0	3.7	2.1	2.5	-0.3	-1.1	-1.1	-2.0	-0.3	4.3	-0.2	2.0	-0.2	4.4
Number of treatments/medications taken	1.2	2.2	5.7	-1.1	-0.5	-0.9	0.9	2.4	2.4	0.9	-1.2	-1.6	-0.3	-2.1	-1.2	-1.8
Average weekly spirits intake	1.3	1.6	5.8	-0.4	-0.6	0.7	0.8	1.7	-0.3	-2.0	-2.4	-1.3	-1.8	-0.0	0.5	-0.9
Sensitivity / hurt feelings	0.4	0.7	3.0	1.1	1.7	1.1	0.5	0.5	-0.3	-0.6	-1.2	0.5	-0.8	0.0	0.3	0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	-0.8	-0.8	-0.6	-0.3	-0.1	0.8	0.6	0.4	0.2	1.0	0.3	0.4	-0.8
Hearing difficulty/problems: Yes	0.7	1.1	3.3	-1.2	-1.4	-0.9	-1.2	0.0	-0.6	-1.8	-0.4	-1.3	-0.2	-1.1	-1.4	-0.0
Relative age of first facial hair	0.9	1.9	4.3	-1.7	-2.0	-1.9	-1.0	0.8	0.4	-0.0	0.9	-2.1	1.0	-1.6	-0.6	-1.6
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.4	1.5	1.6	2.3	2.0	0.3	0.9	-0.8	-1.9	0.9	-1.7	1.4	1.2	-0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.5	0.7	0.4	1.0	0.2	0.5	-0.1	0.1	-1.6	0.6	-1.1	0.8	1.5	0.2
Ever had hysterectomy (womb removed)	0.9	1.0	4.2	-1.2	-1.2	-1.3	0.8	0.9	0.5	0.2	-0.3	-1.0	0.7	-0.7	0.8	-2.1
Systolic blood pressure, automated reading	0.9	2.6	9.3	-3.0	-1.0	-1.8	0.5	0.9	1.2	1.1	1.0	-2.4	0.8	-2.9	-1.0	-0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.6	-0.3	0.3	-0.1	-0.2	0.7	-0.1	-0.5	-1.6	-0.6	-1.2	-0.3	-0.8	1.0
Angina	4.5	5.9	15.9	-2.8	-2.6	-3.2	0.3	1.7	1.8	-1.0	-0.4	-3.2	1.0	-4.0	-3.1	-2.8
Medication for hormone replacement therapy	1.3	1.4	4.0	1.6	0.4	2.0	1.1	-0.0	-0.7	-0.8	-1.1	1.0	-1.4	1.8	1.0	0.8
Vitamin and mineral supplements	0.7	0.9	4.2	-0.9	-2.1	-1.6	-1.0	-0.2	-1.3	0.2	0.2	-0.7	-0.5	-0.7	0.5	-0.3
Supplements: Zinc	0.3	0.4	1.4	-1.2	0.2	0.5	-0.5	-0.8	0.1	0.3	0.6	-1.1	-0.1	0.4	0.3	0.2
Medication: Co-codamol	1.1	1.3	3.2	-1.2	-0.0	-1.7	1.0	-0.2	1.3	1.1	1.0	-1.8	0.9	-1.2	-0.2	-1.3
Medication: Metformin	1.1	1.5	3.6	-1.9	-1.2	-1.6	-0.1	0.8	1.7	1.7	-0.1	-1.9	-0.1	-1.4	-0.4	-0.8
Diabetes (father)	0.8	1.0	3.7	0.4	0.9	1.3	-0.5	1.9	0.2	-0.4	-1.6	-0.1	-1.7	0.1	0.8	-0.6
Diabetes (mother)	1.1	1.4	4.0	-0.9	-0.2	0.2	1.9	-0.0	2.0	0.0	-1.1	-1.7	-1.1	-1.0	-1.4	-1.1
Severe depression (siblings)	2.0	2.2	4.3	1.8	2.0	1.9	0.1	0.6	-0.2	0.9	-2.1	1.3	-1.4	1.4	2.0	1.6
Pack years adult smoking proportion	0.3	0.5	1.0	-0.6	-0.1	-0.5	-1.0	0.8	-0.9	-0.2	-0.4	-0.6	-0.7	-0.8	-0.7	0.8
Impedance of leg (right)	1.4	6.6	17.1	2.6	3.2	1.7	0.9	2.8	4.1	3.1	2.8	3.5	3.1	0.3	0.4	-0.3
Leg fat-free mass (left)	1.4	7.5	29.4	-2.7	-5.4	-2.1	-1.0	-2.9	-3.5	-3.0	-2.9	-3.3	-2.0	0.6	-0.2	-1.1
Trunk fat percentage	1.6	6.3	30.5	-3.2	-5.5	-3.1	0.7	1.7	-0.4	0.2	-1.7	-3.3	0.1	-1.6	-1.1	-3.1
Hand grip strength (right)	1.4	3.8	14.8	2.6	1.7	1.8	-1.4	-1.0	-1.7	-2.5	-0.2	2.8	-0.7	1.1	-0.7	3.9
Townsend deprivation index at recruitment	0.8	1.1	4.5	-1.2	-2.1	-1.6	-1.3	0.7	0.5	0.3	0.4	-0.7	0.9	-0.6	-0.4	-1.3
Current tobacco smoking	1.6	2.6	9.4	-2.1	-2.0	-1.5	1.8	0.0	0.7	1.8	1.0	-2.2	0.6	-0.8	0.2	-3.1
Average weekly fortified wine intake	0.7	0.8	3.8	0.1	1.3	1.0	1.9	0.2	1.0	0.2	-1.0	-0.8	-0.8	0.6	0.4	0.4
Maternal smoking around birth	1.1	1.6	8.6	-0.4	-2.1	-1.2	0.5	-0.0	-0.1	0.9	1.0	-0.5	1.4	0.4	1.3	-2.9
Fed-up feelings	2.0	3.7	14.8	-2.3	-3.9	-3.0	-0.0	1.5	0.8	-0.1	-1.1	-1.8	0.7	-1.4	-0.7	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	5.0	-2.2	-1.8	-1.6	-0.7	-0.2	-0.4	0.4	0.2	-1.9	0.5	-1.3	-1.0	-1.5
Relative age voice broke	0.2	0.4	1.4	0.2	0.5	0.0	0.1	0.0	-0.9	0.7	0.4	0.4	1.2	0.7	0.7	-0.7
Taking other prescription medications	1.9	3.0	6.7	-1.8	-1.4	-2.5	0.4	1.0	1.9	1.2	1.1	-1.7	1.7	-2.2	-1.5	-2.6
Age when periods started (menarche)	1.5	3.6	14.1	0.6	-0.8	1.3	-1.7	-0.4	-0.9	2.4	1.6	1.1	1.4	3.8	3.7	-1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.3	-0.4	-0.5	-0.3	0.5	0.6	-0.7	-0.8	-1.2	-0.0	-0.4	-0.1	1.1	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	6.7	0.8	0.4	1.9	0.6	-0.3	-2.4	-1.0	-2.5	-0.5	-2.2	2.1	2.6	-1.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.2	-1.0	-0.6	-0.0	-1.2	-1.0	-0.9	-0.3	-0.9	-1.8	-1.4	0.2	0.3	-1.4
Qualifications: CSEs or equivalent	3.8	5.0	12.0	-2.8	-2.5	-3.5	0.5	0.3	1.8	1.4	1.0	-1.6	2.7	-3.0	-2.6	-2.6
Serious illness, injury or assault to yourself	1.0	1.2	6.2	-0.4	-0.9	-1.2	0.9	1.9	0.5	0.5	-0.2	-0.2	1.1	-0.6	0.7	-2.5
High blood pressure	0.4	1.1	4.9	0.3	1.7	0.9	0.6	1.6	0.5	0.1	-2.2	-0.7	-0.8	-1.1	0.4	-0.2
Hayfever, allergic rhinitis or eczema	1.6	3.5	11.8	-0.9	0.4	-0.9	1.7	2.2	3.4	-0.6	-0.7	-0.4	0.6	-3.3	-3.4	-0.2
Multivitamins +/- minerals	1.2	1.5	4.6	1.5	2.1	2.1	0.8	-0.3	0.5	-1.1	-0.7	1.1	-1.0	0.9	-0.6	1.7
Stomach or abdominal pain in last month	1.8	2.2	6.1	-2.2	-1.1	-1.6	-0.3	0.2	-0.5	-2.1	-0.6	-2.5	-0.1	-1.5	-1.5	-2.0
Supplements: Glucosamine	1.5	1.9	7.3	1.4	0.3	1.2	1.2	-0.9	-0.4	1.2	0.4	1.4	1.5	2.5	2.7	-0.2
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.0	-0.2	-0.5	0.8	0.8	1.0	-0.7	-0.9	-2.0	-0.5	-1.5	0.7	1.1	-1.6
Medication: Atenolol	1.2	1.5	3.3	-1.2	-1.0	-1.3	-0.6	1.5	-0.5	-1.4	-1.2	-1.7	0.1	-1.8	-0.5	-1.8
Medication: Levothyroxine sodium	1.3	2.2	8.2	-2.1	-2.2	-2.9	0.4	0.4	-0.5	1.5	-0.0	-2.1	0.5	-1.6	-0.4	-1.1
Sitting height	1.3	9.2	25.8	2.1	0.0	2.3	-3.5	-4.1	-4.0	-5.1	-2.2	1.6	-3.1	3.4	1.0	3.0
Chronic bronchitis/emphysema (father)	1.3	1.6	3.6	0.6	0.5	1.6	0.6	-1.5	-1.6	-1.6	-1.0	-0.1	-1.8	1.9	1.4	0.2
High blood pressure (mother)	0.9	1.2	5.1	-0.2	0.5	1.5	-0.5	0.0	0.5	-1.6	-2.3	-0.9	-1.5	0.1	-0.4	-1.4
Body mass index (BMI)	3.2	13.8	56.9	-5.5	-7.5	-5.2	0.8	-0.0	-1.8	-0.4	-2.3	-5.5	-0.2	-3.0	-1.6	-3.7
Impedance of leg (left)	1.4	6.7	16.0	3.0	3.5	1.9	0.8	3.2	4.0	2.7	2.5	3.7	2.7	0.5	0.2	-0.0
Leg predicted mass (left)	1.4	7.5	29.5	-2.7	-5.4	-2.1	-1.1	-2.9	-3.6	-3.0	-2.8	-3.4	-2.0	0.6	-0.2	-1.0
Trunk fat mass	1.6	6.8	38.7	-3.4	-6.2	-3.2	0.4	0.4	-1.3	-0.4	-2.1	-3.4	-0.3	-1.0	-0.7	-2.9
Waist circumference	3.0	11.1	49.0	-4.8	-7.0	-4.4	0.1	0.4	0.3	-0.8	-2.1	-5.0	-0.2	-2.9	-3.0	-2.4
Number of incorrect matches in round	0.8	1.3	4.8	1.6	1.2	0.5	0.0	0.9	-1.1	0.8	0.7	2.2	0.9	1.0	0.8	1.6
Past tobacco smoking	0.7	1.2	5.3	-1.1	1.0	-0.2	-2.3	-0.6	-1.2	-1.1	0.1	-1.2	-0.7	-1.4	-0.4	1.1
Alcohol usually taken with meals	4.9	8.0	22.2	3.1	4.7	4.2	-0.8	-1.3	-1.7	-1.5	-2.2	2.2	-3.5	3.1	2.4	2.9
Nervous feelings	1.3	2.4	6.0	2.2	2.4	1.9	1.1	1.3	-0.0	-1.9	-1.2	2.5	-0.3	0.3	-0.4	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.3	0.1	0.5	0.4	-1.1	0.1	-0.7	-0.0	-1.1	0.1	-0.5	0.8	0.8	-0.4
Hearing difficulty/problems with background noise	0.6	1.0	2.4	-1.4	-0.6	-1.2	-1.6	-0.4	-1.5	-1.1	-0.1	-1.4	-0.1	-1.0	-0.1	-0.4
Hair/balding pattern: Pattern 2	0.6	0.8	3.7	0.3	-0.7	-0.4	0.2	0.8	0.6	1.2	1.2	0.8	1.9	0.4	0.6	-0.9
Had menopause	0.5	0.7	4.5	-0.6	0.6	-0.7	-0.3	-0.3	-0.8	-0.2	2.1	-0.5	1.0	-0.7	-0.1	0.4
Had other major operations	1.1	1.3	5.0	-1.0	-0.7	-1.1	0.5	1.1	-0.8	-0.3	1.1	-1.3	1.4	-0.2	1.5	-2.2
Forced vital capacity (FVC)	1.1	4.1	13.5	2.9	0.3	1.0	-0.3	-2.4	-1.0	0.2	1.4	3.7	2.7	3.2	1.9	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	9.5	1.1	1.4	2.4	0.7	0.4	-1.9	-0.3	-3.1	-0.2	-2.6	2.3	3.0	-1.4
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	11.2	-2.1	-3.4	-2.0	-1.7	-1.4	-1.7	-0.9	1.3	-1.9	1.0	-0.1	0.6	-2.1
Qualifications: None of the above	5.0	10.8	27.1	-3.8	-4.1	-4.4	2.6	3.7	1.3	2.7	0.4	-3.1	2.3	-3.8	-1.8	-5.2
Financial difficulties in last 2 years	3.1	4.1	20.8	-2.7	-4.6	-2.4	0.6	-0.1	1.8	0.1	-1.2	-3.0	-0.6	-1.5	-1.3	-1.2
Mouth/teeth dental problems	1.4	2.1	7.8	1.5	1.3	1.4	0.7	-0.1	1.8	1.2	0.2	2.8	-0.5	-0.5	-1.5	2.5
Heart attack	1.3	1.7	6.3	-1.5	-2.5	-2.4	-0.2	0.8	-0.2	-0.6	-0.5	-1.5	0.6	-1.1	-0.1	-1.6
Allergy	2.2	5.2	21.2	2.4	1.5	2.3	0.2	-1.9	-2.3	1.4	0.2	2.1	-0.8	4.6	4.0	0.7
Pain all over the body in last month	1.5	1.6	5.0	-2.2	-0.9	-0.9	-0.8	1.3	1.5	0.3	-0.1	-2.0	-0.1	-1.5	-1.1	-1.3
Diabetes (self-reported)	2.2	3.4	10.4	-2.9	-2.5	-2.4	-1.1	0.6	1.5	-0.1	0.3	-3.2	-0.0	-2.6	-0.9	-1.6
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	8.5	-1.1	-0.0	-0.8	-0.8	1.3	2.9	1.3	1.1	-0.3	0.6	-2.2	-2.1	-0.1
Medication: Ramipril	1.0	1.2	3.5	-1.5	-0.2	-0.4	0.1	-1.1	0.9	-0.6	-0.9	-1.9	-1.1	-1.6	-1.8	0.0
Medication: Simvastatin	0.8	1.2	5.0	-0.7	0.6	-0.7	1.7	-0.0	1.7	0.7	-0.7	-1.0	0.6	-1.1	0.1	-2.2
Fluid intelligence score	6.9	14.3	28.4	5.3	4.2	5.3	-0.8	-3.7	-1.0	-1.5	-0.5	4.8	-3.2	5.1	3.5	4.8
Illnesses of siblings	0.6	0.8	2.2	0.9	0.7	1.0	-0.6	-0.4	-0.9	-0.3	-0.2	0.7	-1.3	1.3	0.9	1.5
Neuroticism score	0.5	1.0	5.5	0.5	1.1	0.9	1.1	1.0	0.1	-0.9	-2.4	0.2	-1.3	0.0	0.5	-0.0
Weight	1.9	9.3	47.7	-3.9	-6.9	-3.7	-0.3	-1.4	-2.4	-1.9	-2.6	-4.1	-0.8	-1.0	-1.0	-2.4
Impedance of arm (right)	1.5	7.2	24.4	4.2	4.9	4.2	0.6	0.9	2.7	0.8	1.5	3.6	-0.5	2.3	0.9	1.8
Arm fat percentage (right)	2.2	8.7	34.8	-4.3	-5.9	-3.9	1.4	0.4	-0.8	0.0	-1.9	-4.4	-0.4	-2.3	-1.3	-3.5
Trunk fat-free mass	0.9	5.4	17.9	-1.9	-4.2	-1.6	-0.6	-3.7	-3.5	-2.4	-2.1	-2.1	-1.1	1.4	0.9	-0.7
Hip circumference	1.8	7.8	39.3	-3.0	-6.3	-3.2	-1.0	-0.6	-3.7	-2.1	-2.8	-3.2	-0.7	0.1	0.6	-2.0
Time employed in main current job	1.0	1.2	2.8	1.2	1.4	1.6	-0.0	-1.7	-0.5	-0.5	-0.5	1.3	-1.0	1.4	0.5	0.9
Alcohol intake versus 10 years previously	1.1	1.6	4.6	-1.6	-2.1	-2.1	0.3	0.0	0.2	-0.2	0.3	-2.0	0.1	-1.7	-1.4	-0.6
Father’s age at death	2.7	3.6	11.4	2.9	2.7	2.3	0.5	-0.8	-0.3	1.3	0.6	3.4	-0.5	2.0	1.3	2.3
Worrier / anxious feelings	1.1	2.1	6.3	1.1	2.5	2.0	0.6	0.1	-0.7	-1.7	-2.3	1.0	-2.0	0.2	0.4	1.1
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.3	17.2	-3.9	-4.1	-3.6	-0.5	-0.4	0.5	-0.3	-0.1	-3.2	1.3	-2.4	-1.1	-4.2
Falls in the last year	1.6	2.1	6.1	-2.5	-1.6	-1.5	-0.7	0.1	-0.0	-2.1	1.0	-2.1	0.4	-1.4	-1.1	-1.9
Hair/balding pattern: Pattern 3	3.3	4.9	13.9	3.2	3.2	3.2	0.6	0.1	-0.2	-1.3	-1.0	2.8	-2.0	1.8	0.4	3.7
Number of live births	0.1	0.2	0.5	-0.7	-0.5	-0.4	-0.5	0.5	-0.3	-0.4	-0.3	-0.5	-0.6	-0.6	0.0	-0.1
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	13.9	2.0	-0.0	0.2	0.3	-2.9	-0.5	0.8	2.4	2.8	3.7	2.8	2.2	-0.7
Pulse rate	0.2	0.4	1.0	-0.6	-1.0	-0.4	0.3	0.9	0.3	-1.0	-0.1	-0.9	-0.4	-0.4	-0.3	-0.4
Happiness	0.3	0.3	1.1	0.3	0.4	0.3	-0.8	-0.8	-0.3	-0.4	0.7	0.8	0.0	0.6	0.4	1.0
Noisy workplace	2.7	3.3	7.7	-1.9	-2.7	-1.7	-0.1	1.4	-1.1	-1.2	-2.4	-2.5	-1.0	-1.5	-1.0	-2.8
Qualifications: A levels/AS levels or equivalent	3.0	6.7	21.2	3.5	4.6	3.5	0.3	-2.2	1.5	-2.1	-0.5	2.7	-1.7	0.8	-1.2	4.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	5.3	-0.0	-0.3	0.7	0.5	-1.5	0.2	-0.9	-2.3	-0.5	-2.0	0.6	-0.2	-0.2
Mouth/teeth dental problems: Dentures	1.8	3.0	9.3	0.9	1.0	1.3	-0.5	0.5	-2.7	-2.3	-3.1	-1.0	-2.5	1.5	1.7	-0.6
Asthma	4.7	9.3	31.0	-4.3	-3.3	-4.2	-1.2	0.6	1.4	-0.6	0.4	-4.3	1.6	-5.6	-3.8	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.1	-0.2	0.2	0.4	0.4	0.3	0.9	0.4	-0.5	-0.2	-0.3	1.1	-0.2	0.2
Medication: Cholesterol lowering	0.6	1.0	2.8	-0.7	-1.2	-1.7	1.0	0.4	0.5	0.2	-0.1	-0.5	1.2	-1.4	-0.5	-1.7
Depression (self-reported)	0.5	0.6	3.7	-0.2	0.1	0.6	0.1	-0.5	0.6	1.9	-0.6	0.2	0.2	0.8	0.8	-0.9
Medication: Lansoprazole	0.2	0.3	1.6	-0.1	0.3	-0.2	1.3	0.4	-0.2	-0.8	0.3	-0.6	-0.1	-0.1	0.3	-0.3
Prospective memory result	0.9	1.1	5.6	0.2	-0.7	0.3	2.2	2.4	-0.2	0.2	-1.6	0.1	-0.1	-0.5	0.2	-0.6
Lung cancer (father)	1.3	1.5	4.2	-1.4	-0.7	-2.0	0.1	-0.5	-0.4	0.0	1.5	-1.1	1.6	-1.7	-1.9	-0.1
Illnesses of mother	0.9	1.2	7.1	-0.3	-0.9	-1.2	-0.6	-0.4	-0.8	1.3	2.7	0.1	1.0	0.1	0.4	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	10.8	1.7	0.1	0.1	0.2	-3.0	-0.2	0.3	1.9	2.4	3.3	2.4	2.0	-1.0
Pulse wave Arterial Stiffness index	1.2	1.4	4.7	0.1	-0.5	-0.0	-1.5	1.2	-1.8	-2.2	-1.7	0.4	-0.8	-0.5	-0.3	1.5
Impedance of arm (left)	1.5	6.8	23.1	4.1	4.8	4.0	-0.1	1.3	2.9	0.4	1.2	3.6	-0.5	1.9	0.5	1.9
Arm fat mass (right)	2.5	10.4	47.7	-4.5	-6.9	-4.2	0.5	-0.2	-1.9	-0.9	-2.5	-4.7	-0.8	-1.8	-1.0	-3.4
Trunk predicted mass	0.9	5.4	18.6	-1.9	-4.3	-1.6	-0.6	-3.7	-3.5	-2.4	-2.1	-2.1	-1.1	1.4	0.8	-0.6
Standing height	0.6	6.2	19.3	2.9	0.3	2.7	-2.2	-3.1	-1.9	-3.4	-1.0	2.3	-1.4	4.4	1.4	2.5
Length of working week for main job	0.8	0.9	2.8	0.3	-1.0	0.2	-1.6	-0.4	-1.7	-1.2	0.0	0.6	-0.6	0.9	0.2	1.3
Exposure to tobacco smoke at home	1.4	1.6	4.7	-0.9	-0.0	-0.7	2.1	0.3	2.2	0.5	-0.1	-1.3	0.0	-1.9	-2.1	-0.6
Breastfed as a baby	1.7	2.1	5.2	1.8	0.3	1.2	-0.6	-0.0	-2.1	-0.0	0.9	2.3	0.7	2.3	1.7	1.6
Tense / ‘highly strung’	1.2	2.0	6.2	2.0	2.5	1.4	-0.0	1.6	0.2	-0.6	-1.7	2.1	-0.6	1.6	0.8	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	7.4	-1.2	-0.5	-0.1	0.2	1.1	-0.1	-0.3	-0.9	-1.5	-0.8	-0.1	-0.1	-2.7
Hair/balding pattern: Pattern 4	1.1	2.7	5.4	2.3	2.2	2.0	2.2	1.3	-0.3	0.6	-0.6	2.2	0.1	2.0	2.1	0.2
Birth weight of first child	0.4	0.8	2.0	0.9	0.3	1.3	-0.7	-0.1	-1.4	-0.5	0.6	1.4	-0.4	1.0	0.5	1.2
Peak expiratory flow (PEF)	0.5	1.2	5.9	1.0	-0.4	-0.0	1.0	-1.4	0.0	0.1	1.1	1.6	2.4	1.0	0.5	-0.3
Pulse wave reflection index	0.3	0.4	1.0	-0.1	0.0	0.0	-0.9	0.7	-1.0	-0.6	-1.0	0.4	-0.7	-0.2	0.3	0.8
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.9	-1.7	-1.2	-0.9	-0.7	0.4	0.8	0.3	-1.0	-1.3	-0.3	-0.7	-1.7	-0.1
Loud music exposure frequency	1.3	1.4	3.8	-1.8	-0.7	-0.7	-1.5	-0.9	-1.3	0.0	-1.4	-1.9	-1.0	-0.2	0.6	-1.3
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	16.3	-0.7	1.5	-0.1	-1.2	-1.4	1.7	-2.5	0.7	-1.0	-0.5	-2.6	-4.0	3.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	5.3	-1.5	-2.3	-0.8	-0.7	-0.6	-0.6	-1.1	-0.9	-1.9	-0.6	0.2	0.4	-0.7
Blood clot in the leg (DVT)	0.3	0.4	1.3	-0.2	-0.4	-0.3	0.2	-0.7	-0.2	-1.1	-0.8	-0.4	-0.5	-0.8	-0.8	0.6
Medication: Paracetamol	2.1	3.5	12.4	-2.2	-2.0	-1.9	0.7	1.0	1.9	-0.4	0.0	-2.2	-0.3	-2.7	-3.5	-1.7
Headache pain in last month	3.5	6.0	11.3	-3.1	-3.4	-3.0	1.8	0.2	1.5	-1.5	0.5	-2.9	2.2	-3.2	-2.6	-3.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.9	0.3	0.3	0.8	-1.0	-1.0	-1.0	-0.1	1.0	0.8	-0.3	1.6	0.5	1.7
Glaucoma (self-reported)	0.4	0.5	2.3	-0.3	-0.6	-0.4	-1.3	-0.3	-1.1	-1.5	-0.1	-0.5	-0.1	0.1	0.2	0.3
Gout (self-reported)	0.7	1.0	4.0	1.0	2.0	1.2	-0.2	-1.2	-0.6	0.7	-0.9	1.0	-0.8	0.5	0.6	0.6
Hypothyroidism/myxoedema (self-reported)	2.6	5.1	19.6	-2.9	-2.4	-4.4	0.2	1.4	-0.3	1.6	1.0	-2.9	1.9	-3.1	-1.5	-1.7
Medication: Amlodipine	0.4	0.6	2.3	0.5	0.5	0.6	0.6	0.2	1.5	0.4	-1.0	-0.1	-1.5	-0.7	-0.2	-0.1
Medication: Ventolin 100micrograms inhaler	6.1	7.9	23.4	-3.9	-3.1	-3.9	-0.8	0.3	2.2	0.8	0.7	-3.8	1.6	-4.8	-3.7	-1.2
Birth weight	0.1	0.3	1.4	0.2	-1.2	0.3	0.3	0.4	0.6	0.3	-0.1	-0.0	-0.2	0.6	0.7	0.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	-1.1	-1.3	-1.1	-0.6	0.4	-0.4	1.1	-0.2	-1.4	-0.2	-0.6	0.4	-0.6
High blood pressure (siblings)	0.1	0.1	0.2	-0.3	0.3	0.5	0.3	-0.1	0.5	-0.3	-0.4	-0.5	0.1	-0.5	-0.4	-0.4
Forced vital capacity (FVC), Best measure	1.0	3.7	11.6	2.9	0.9	1.1	-0.3	-2.5	-0.8	-0.2	0.9	3.4	2.4	2.9	2.0	0.2
Body fat percentage	2.0	7.9	36.4	-3.7	-6.0	-3.7	1.2	1.6	-0.4	0.4	-1.7	-3.6	0.3	-2.1	-1.1	-3.6
Leg fat percentage (right)	3.2	11.7	46.8	-4.9	-6.8	-5.0	1.7	1.2	-0.0	1.0	-1.4	-4.2	1.4	-3.1	-1.2	-4.3
Arm fat-free mass (right)	1.2	6.1	31.2	-2.6	-5.6	-2.6	-0.5	-2.2	-3.1	-2.1	-2.3	-2.6	-0.6	0.3	-0.0	-1.6
Exposure to tobacco smoke outside home	0.6	0.7	3.3	-0.0	0.4	0.9	0.4	0.9	0.7	-0.0	-0.7	-0.5	-1.8	-0.4	-1.1	1.3
Comparative body size at age 10	0.4	1.1	8.0	0.3	0.1	0.9	-0.1	-2.8	-0.8	-0.4	-0.7	0.5	-1.0	1.4	1.0	0.5
Number of full brothers	1.2	1.6	4.4	-2.0	-1.6	-2.0	-0.4	-0.4	-1.0	0.4	0.3	-2.1	0.6	-1.0	-0.5	-1.5
Worry too long after embarrassment	0.9	1.5	8.7	0.7	-0.0	0.7	0.1	-0.7	-1.0	-1.7	-2.9	0.4	-1.3	0.5	1.3	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.8	-0.5	0.3	0.1	0.5	0.4	0.8	-0.0	0.7	-0.1	0.9	-0.8	-0.9	-0.6
Wheeze or whistling in the chest in last year	5.1	9.0	20.4	-4.5	-3.7	-4.4	-1.0	-0.4	0.3	2.0	1.8	-3.8	2.7	-4.3	-2.5	-2.9
Number of children fathered	0.8	0.9	2.7	-1.6	-1.0	-1.0	0.3	-0.4	-0.3	0.3	0.4	-1.4	1.5	-1.0	-1.0	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	5.6	2.4	1.1	1.8	-0.5	0.9	-1.6	-1.3	-0.4	2.2	-0.3	2.0	2.0	0.1
Age at first live birth	1.3	2.3	6.6	1.0	2.1	2.4	-0.8	-1.3	-1.1	-1.9	0.7	1.2	-1.3	1.1	-0.4	2.6
Pulse wave peak to peak time	1.1	1.2	3.4	0.1	0.7	0.3	1.4	-1.4	1.6	1.9	1.6	-0.2	0.6	0.9	0.5	-1.3
Health satisfaction	0.8	1.1	3.3	0.4	-0.2	-0.8	1.6	1.8	1.5	0.4	-0.6	0.4	0.9	-0.9	-0.9	-1.2
Shortness of breath walking on level ground	0.8	0.9	2.4	-1.3	-0.7	-1.0	0.3	1.0	0.4	-0.3	0.1	-1.6	-0.0	-1.4	-1.5	0.6
Qualifications: College or University degree	8.3	26.3	65.6	6.5	8.1	7.5	-1.2	-3.0	-2.2	-2.0	-1.7	5.8	-4.4	5.4	2.6	8.1
Eye problems/disorders: None of the above	1.1	1.3	5.9	-0.4	-0.3	-1.5	0.4	0.4	0.3	1.1	1.4	0.3	2.4	-1.2	-0.0	-1.8
Mouth/teeth dental problems: Loose teeth	1.0	1.1	4.5	0.3	-0.2	0.4	-0.1	-1.3	-1.6	-0.8	0.6	-0.2	0.5	2.1	1.9	-0.8
Emphysema/chronic bronchitis	0.6	0.7	1.7	-0.3	-0.6	-0.8	0.5	1.2	0.7	1.1	0.8	0.1	1.3	-1.2	-0.4	-0.0
Medication for pain relief, constipation, heartburn	2.5	4.3	13.3	2.4	1.7	2.2	-1.5	-1.1	-2.0	-0.4	1.0	2.3	0.3	3.6	3.7	1.4
Neck or shoulder pain in last month	2.0	2.8	7.3	-2.7	-1.1	-1.7	-0.3	1.7	0.9	-0.9	0.8	-2.4	1.2	-1.8	-1.5	-2.6
Medication: Blood pressure	0.2	0.4	1.5	-0.3	-0.0	-0.7	-0.3	0.6	0.4	0.2	-0.8	-0.6	0.0	-1.2	-0.2	-0.9
Angina (self-reported)	4.4	5.7	15.0	-2.7	-2.6	-3.0	0.5	1.6	1.7	-1.4	-0.6	-3.3	0.7	-3.9	-3.0	-2.8
Migraine (self-reported)	0.2	0.3	0.9	-0.7	-0.3	-0.2	0.9	-0.2	0.1	-0.9	-0.2	-0.5	0.6	-0.6	-0.4	-0.7
Medication: Ibuprofen	0.3	0.4	2.4	0.0	0.1	0.8	-0.0	0.6	0.6	0.5	-0.8	-0.2	-0.5	1.6	0.4	0.1
Medication: Allopurinol	0.9	1.2	7.8	1.2	2.8	1.7	0.8	0.1	-0.0	0.0	-0.6	1.1	-0.5	-0.3	-0.4	1.2
Medication: Omeprazole	3.0	3.5	6.8	-1.7	-2.1	-2.1	1.6	2.3	0.7	2.6	1.8	-1.0	2.3	-1.8	0.4	-2.3
Medication: Seretide 50 evohaler	2.5	2.9	11.3	-1.9	-0.7	-1.7	-0.8	0.9	1.5	0.9	1.3	-1.6	1.3	-3.4	-2.9	-0.3
Mean time to correctly identify matches	0.3	0.6	1.9	-0.7	0.9	0.6	-0.5	0.7	-0.5	-1.1	-0.8	-1.4	-1.2	-0.3	-0.3	0.3
Heart disease (mother)	0.7	0.8	3.8	0.4	1.6	0.9	-0.2	0.1	-0.3	-1.2	-1.9	0.1	-1.4	0.3	0.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	6.9	1.9	0.7	1.0	0.6	0.6	-0.3	-0.9	0.0	2.6	0.2	0.3	-0.7	1.6
Whole body fat mass	2.2	9.0	46.6	-4.1	-6.8	-3.8	0.4	0.2	-1.7	-0.7	-2.3	-4.1	-0.4	-1.4	-0.8	-3.3
Leg fat mass (right)	3.1	12.0	58.7	-5.0	-7.7	-4.8	0.9	0.1	-1.3	-0.1	-2.1	-4.7	0.4	-2.3	-1.0	-3.8
Arm predicted mass (right)	1.1	5.8	30.1	-2.4	-5.5	-2.5	-0.5	-2.1	-3.0	-2.1	-2.4	-2.5	-0.6	0.4	-0.0	-1.5
Pulse rate, automated reading	0.3	0.9	3.1	-0.9	-1.6	-1.3	0.5	1.8	0.7	-0.1	-0.3	-0.8	-0.9	-0.8	-0.5	-0.4
Alcohol intake frequency.	2.6	6.0	17.0	-3.7	-2.9	-2.7	0.8	1.6	0.8	-1.1	-1.7	-4.1	-0.3	-3.4	-2.6	-2.6
Comparative height size at age 10	0.2	0.9	3.6	0.1	0.6	0.7	0.3	-1.9	0.9	-0.8	-0.4	-0.1	-0.4	0.1	-1.3	1.9
Number of full sisters	3.7	4.4	17.3	-3.4	-1.8	-2.1	0.2	0.6	2.0	0.0	0.1	-4.2	-0.4	-2.8	-2.6	-1.3
Suffer from ‘nerves’	1.2	1.8	5.6	0.6	2.4	1.0	1.6	1.0	0.2	-2.1	-1.3	-0.2	-1.2	-1.2	-1.8	1.2
Overall health rating	2.3	5.0	11.7	-3.3	-2.7	-2.6	0.6	1.6	1.4	-0.3	-0.2	-2.8	0.6	-3.4	-2.5	-3.0
Chest pain or discomfort	1.9	2.7	9.3	-2.0	-1.5	-1.7	0.8	-0.4	-0.6	-1.2	-1.4	-3.0	-0.2	-1.9	-0.1	-2.9
Had major operations	0.8	0.9	3.2	-1.2	-1.1	-0.6	-0.4	-1.2	0.4	-0.3	1.0	-1.2	1.8	-0.2	-1.1	-0.6
Age at last live birth	1.1	1.5	7.0	0.2	1.4	1.0	-0.9	-1.6	-1.3	-1.2	1.4	0.7	0.2	-0.0	-1.0	2.6
Family relationship satisfaction	0.9	1.1	3.8	-0.9	0.0	-0.6	0.1	-0.2	1.4	1.0	1.4	-0.4	0.3	-1.1	-1.6	1.9
Leg pain on walking	2.0	2.5	6.8	-1.7	-1.5	-2.2	-0.0	0.8	0.9	-0.2	0.2	-2.2	0.4	-2.1	-2.1	-2.6
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	7.7	-1.6	-2.5	-2.3	-1.6	0.7	-0.5	0.7	1.4	-1.6	2.1	-0.1	1.3	-2.8
Commuting to job workplace: Car/motor vehicle	2.3	2.7	7.8	-1.0	-1.8	-1.7	2.0	2.8	1.6	1.1	0.1	-0.7	2.4	-1.4	-0.7	-1.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	3.4	0.2	1.8	0.1	-0.1	-0.4	-1.0	0.1	1.4	0.6	1.0	-0.8	-0.3	0.0
Medication: Aspirin	1.3	1.8	8.5	-1.4	-0.5	-1.1	0.4	-0.7	0.2	-0.5	-1.6	-1.3	-0.3	-2.4	-2.9	0.1
Supplements: Vitamin C	0.5	0.5	1.6	0.2	0.8	0.8	1.3	0.1	0.9	-0.5	0.2	0.5	1.1	0.5	-0.1	-1.2
Knee pain experienced in last month	1.4	2.1	9.2	-1.6	-0.8	-1.6	1.6	1.1	0.5	0.0	-0.9	-2.6	0.0	-1.0	-0.1	-3.0
Hypertension (Self-reported)	0.3	0.9	4.1	0.3	1.6	0.8	0.4	1.3	0.3	0.1	-2.0	-0.8	-0.8	-1.1	0.6	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	-1.1	-0.0	-0.4	1.4	1.0	0.3	0.2	0.6	-0.8	0.7	-0.6	0.3	-0.9
Illnesses of father: Heart disease	0.5	0.7	2.1	-0.1	-0.1	-0.1	1.4	-1.0	0.4	-1.4	0.8	0.3	1.0	-1.3	-0.6	-0.7
Illnesses of siblings: Diabetes	1.5	1.9	5.6	-1.1	-2.4	-2.0	1.3	0.8	0.5	0.6	1.3	-0.9	1.7	-1.6	-0.8	-1.3
Smoking status: Previous	1.0	1.5	5.3	1.5	-0.3	0.7	2.3	0.8	1.3	1.4	-0.5	1.7	0.6	1.6	0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	2.2	-0.1	0.7	0.6	-0.5	-0.6	1.0	0.4	-0.5	0.0	-0.3	-0.4	-1.5	0.4
Whole body fat-free mass	1.1	6.5	24.9	-2.3	-5.0	-1.9	-0.8	-3.2	-3.7	-2.8	-2.6	-2.7	-1.5	1.1	0.4	-0.9
Leg fat-free mass (right)	1.4	7.3	24.9	-2.4	-5.0	-1.8	-1.3	-2.9	-3.6	-3.5	-3.0	-3.2	-2.4	0.7	-0.5	-0.7
Arm fat percentage (left)	2.3	9.2	38.7	-4.4	-6.2	-4.0	1.3	0.7	-0.6	-0.1	-2.0	-4.4	-0.3	-2.5	-1.4	-3.5
Average weekly red wine intake	3.2	4.7	7.4	2.0	1.8	2.7	-1.8	-2.6	-2.6	-1.7	-1.5	2.0	-2.3	2.7	2.2	1.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.7	0.1	-0.5	0.4	-1.3	0.5	-0.7	-0.7	-0.6	0.2	0.1	0.3	-0.1	0.9
Mood swings	0.3	0.5	2.9	-0.4	-0.5	-0.5	0.7	1.3	0.1	-0.6	-1.7	-0.2	-0.1	-0.2	0.5	-0.8
Loneliness, isolation	1.2	1.6	5.4	-1.6	-0.3	-1.3	0.0	1.5	1.2	0.1	0.7	-1.3	0.2	-2.3	-2.3	-0.4
Long-standing illness, disability or infirmity	1.7	2.6	7.2	-1.4	-0.5	-1.8	0.1	0.8	2.6	0.1	-0.1	-2.2	0.5	-2.6	-1.5	-2.7
Ever had bowel cancer screening	1.2	1.5	4.0	1.2	0.9	1.5	1.3	-0.5	-0.6	-0.8	-1.2	1.0	-1.4	1.6	2.0	0.7
Diabetes diagnosed by doctor	1.7	2.9	8.6	-2.6	-1.8	-2.1	-0.5	1.2	1.8	0.8	-0.2	-2.9	-0.3	-2.4	-0.8	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	5.5	1.2	0.4	-0.1	-2.3	-2.1	-2.1	-1.0	1.4	1.8	1.0	1.3	0.7	1.0
Friendships satisfaction	1.1	1.4	7.2	0.8	1.7	1.6	-0.1	-1.1	0.7	-0.0	1.0	0.6	-0.6	1.1	-0.6	2.7
Qualifications: nursing, teaching	1.5	2.3	6.1	1.6	2.0	2.3	0.0	-2.0	-0.7	-1.5	-0.4	1.2	-1.4	1.4	0.0	2.5
Commuting to job workplace: Walk	2.0	2.2	5.6	0.8	2.4	1.4	-2.1	-1.6	-1.8	-0.8	-0.2	0.4	-1.4	1.2	1.1	2.2
Eye problems/disorders: Cataract	0.7	0.8	2.3	0.3	-0.9	0.4	0.1	1.0	-0.7	-0.1	-1.5	-0.4	-1.1	1.4	1.3	-0.6
Mouth/teeth dental problems: Mouth ulcers	4.8	7.6	21.0	-3.3	-1.7	-4.0	-0.1	0.9	1.3	2.1	3.7	-2.7	4.6	-2.7	-1.3	-3.3
Medication for cholesterol	1.3	2.0	11.3	-0.1	-0.5	-1.0	-0.9	-2.0	-1.0	0.9	3.4	1.0	2.1	1.0	-0.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	-1.0	1.1	0.1	-0.8	0.7	0.1	-0.6	-0.9	-0.8	-1.1	-1.4	-0.7	0.2
Back pain experienced in last month	0.7	1.0	4.0	-0.4	-2.0	-1.2	0.1	0.4	0.2	-1.6	-0.9	0.3	0.8	-0.8	-0.8	-1.3
Mineral and other dietary supplements	1.5	2.1	6.2	-1.7	-1.1	-0.5	-1.4	0.8	-0.4	-1.4	-1.1	-2.1	-2.5	-1.7	-1.8	0.1
Breast cancer (self-reported)	0.4	0.4	3.4	-0.5	1.9	0.6	0.1	-0.1	0.5	0.4	0.0	-0.7	-0.3	0.5	0.6	0.1
Asthma (self-reported)	4.3	8.5	27.1	-4.1	-3.3	-4.2	-1.4	0.7	1.1	-0.4	0.5	-4.1	1.8	-5.2	-3.4	-1.6
Osteoporosis (self-reported)	0.2	0.2	0.6	-0.6	-0.3	-0.7	0.6	-0.0	-0.0	-0.7	0.7	-0.4	0.2	-0.4	-0.2	-0.7
Osteoarthritis (self-reported)	1.2	1.5	6.0	-0.0	0.1	0.3	-0.4	0.3	-1.7	-1.1	-2.5	-0.8	-1.6	0.8	1.9	-1.4
Medication: Aspirin	1.8	2.3	8.5	-1.9	-1.5	-1.5	-0.1	-1.0	-0.0	-0.6	-1.5	-1.9	-0.0	-2.5	-2.9	-0.4
Medication: Gliclazide	0.8	0.9	3.7	-0.8	0.1	-0.1	0.1	0.8	1.3	1.2	-0.3	-1.9	-1.0	-1.0	-0.7	-0.8
Illnesses of father: None of the above (group 1)	0.9	1.1	4.9	0.9	0.5	0.7	-1.1	-0.3	-0.5	1.0	-0.3	1.3	-0.8	2.2	1.2	1.3
Smoking status: Current	1.6	2.5	8.7	-1.8	-2.2	-1.5	1.9	0.1	0.9	1.7	1.4	-1.8	0.9	-0.7	0.2	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.4	2.3	1.4	0.9	1.4	-0.7	-0.1	0.5	0.2	2.3	1.7	1.5	1.2	0.2
Whole body water mass	1.2	6.6	25.2	-2.4	-5.0	-2.0	-0.7	-3.3	-3.7	-2.7	-2.5	-2.8	-1.5	1.0	0.3	-0.9
Leg predicted mass (right)	1.4	7.3	24.7	-2.3	-5.0	-1.7	-1.3	-3.0	-3.7	-3.5	-3.0	-3.1	-2.4	0.8	-0.4	-0.6
Arm fat mass (left)	2.7	11.0	51.8	-4.6	-7.2	-4.4	0.6	-0.2	-1.7	-0.9	-2.4	-4.7	-0.4	-2.0	-1.2	-3.5
Number of self-reported non-cancer illnesses	1.1	2.0	5.1	-1.6	-0.9	-1.2	-0.3	1.8	1.1	0.0	-1.3	-2.1	-0.1	-2.3	-0.5	-2.0
Average weekly champagne plus white wine intake	1.1	1.5	4.2	0.4	0.0	1.4	-1.9	-1.6	-0.5	-1.2	2.0	0.6	-0.7	1.7	1.3	-0.2
Miserableness	0.3	0.5	1.9	-0.0	-0.3	-1.0	-0.3	0.8	-1.0	-0.8	-0.7	0.2	0.2	0.1	1.4	-0.7
Guilty feelings	2.6	3.9	7.1	1.9	1.4	2.3	0.6	-1.1	-2.5	-1.6	-2.7	1.1	-2.6	2.1	2.3	1.8
Wears glasses or contact lenses	0.2	0.2	0.6	-0.3	-0.8	-0.5	-0.2	-0.4	0.1	-0.6	-0.1	-0.7	0.4	-0.1	0.5	-0.7
Ever taken oral contraceptive pill	0.2	0.3	1.1	0.5	-0.4	0.2	-0.7	0.4	-0.3	0.2	-0.1	0.4	0.1	0.7	1.0	-0.7
Hearing aid user	1.3	1.5	4.2	1.4	0.8	2.0	1.7	0.8	1.1	0.2	-1.7	1.2	-0.4	-0.5	-1.4	1.0
Mother’s age at death	2.9	3.6	10.7	2.2	3.3	2.8	-0.8	-0.1	-1.2	-0.8	-1.4	1.2	-2.5	1.6	0.3	3.0
Financial situation satisfaction	0.5	0.7	1.7	-0.8	-0.8	-1.1	0.8	1.0	1.1	0.5	-0.5	-1.3	0.1	-0.9	-0.3	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.5	2.6	-0.3	-0.8	0.3	1.2	0.0	1.6	0.3	-0.6	-0.3	-0.2	-0.3	-1.1	-0.6
Commuting to job workplace: Public transport	4.5	5.4	17.8	2.7	4.2	3.3	-0.9	-2.0	-0.8	-0.1	1.3	2.1	-2.2	2.2	1.0	3.5
Eye problems/disorders: Glaucoma	0.8	0.9	2.6	-0.9	-0.3	-0.1	-1.0	-0.9	-0.9	-1.6	-1.3	-1.6	-1.2	0.0	0.1	-0.6
Medication: Blood pressure	0.9	1.6	8.6	-0.1	0.9	1.3	0.5	1.8	1.2	-0.7	-2.9	-0.9	-1.6	-1.2	0.1	-0.6
Pain type(s) experienced in last month: Hip pain	1.0	1.3	5.0	-1.5	-1.0	-1.0	-0.4	0.1	-0.2	-0.3	-1.2	-1.9	-0.4	-1.0	-1.2	-2.2
Supplements: Fish oil (including cod liver oil)	1.6	2.1	4.2	1.3	1.2	0.8	1.5	-1.7	-0.1	1.3	1.6	2.1	1.9	1.8	2.0	-0.3
High cholesterol (Self-reported)	0.4	0.6	1.9	-0.2	-1.0	-0.8	1.4	1.1	0.9	0.3	-0.3	-0.2	0.6	-0.8	0.6	-1.0
Medication: Bendroflumethiazide	0.4	0.7	2.4	0.7	0.8	0.6	-0.0	1.3	0.7	0.4	-1.6	0.4	-1.1	-0.5	0.8	-0.2
Medication: Paracetamol	2.2	3.4	10.5	-1.9	-1.3	-1.5	0.4	1.6	2.0	-0.7	-0.0	-2.2	-0.0	-3.0	-3.2	-2.2
Medication: Lisinopril	0.8	1.0	4.1	0.4	0.4	1.1	-0.3	0.4	0.0	-1.4	-1.9	-0.7	-2.0	0.2	-0.1	1.3
Medication: Atorvastatin	1.0	1.2	4.5	-0.5	-0.9	-1.3	0.9	2.1	0.2	-0.1	-0.4	-0.6	-0.4	-2.1	-1.6	0.5
Illnesses of father: High blood pressure	0.9	1.2	4.4	1.2	-0.2	1.6	0.4	0.6	-0.1	-2.1	-2.0	0.1	-0.3	0.6	0.2	-1.3
Alcohol drinker status: Never	0.9	1.0	4.7	-0.7	-0.3	-0.4	2.2	1.5	1.4	-0.1	-0.3	-0.7	-0.3	-0.6	-0.4	-1.6
Ever smoked	0.8	1.4	7.2	1.0	-0.4	0.4	2.7	1.1	2.1	0.6	0.0	0.9	0.1	0.4	-1.4	-0.3
Basal metabolic rate	1.3	7.3	31.7	-2.9	-5.6	-2.5	-0.7	-2.9	-3.4	-2.6	-2.6	-3.2	-1.4	0.5	-0.1	-1.4
Leg fat percentage (left)	3.0	11.0	45.6	-4.7	-6.8	-4.9	1.4	1.4	-0.4	0.6	-1.4	-4.2	1.2	-2.8	-1.2	-4.1
Arm fat-free mass (left)	1.3	6.4	32.8	-2.7	-5.7	-2.8	-0.2	-2.3	-3.1	-2.1	-2.1	-2.7	-0.5	0.3	0.1	-1.8
Number of operations (self-reported)	0.8	1.2	3.5	-1.7	-1.1	-0.8	-1.5	0.5	-0.6	-1.2	-0.4	-1.9	0.8	-0.3	0.1	-1.5
Average weekly beer plus cider intake	0.5	0.7	4.5	-0.6	-2.1	-0.7	0.2	-0.4	0.9	0.9	0.7	-0.6	0.5	0.2	-0.6	-0.4
Irritability	0.2	0.4	2.1	0.1	0.4	-0.0	-0.4	0.8	0.2	-0.2	-1.4	-0.3	-0.0	0.9	1.0	-0.2
Risk taking	1.7	2.5	7.8	0.8	0.2	1.2	-1.6	1.6	-2.8	0.6	-0.8	0.7	-1.0	2.6	2.7	0.6
Ever had prostate specific antigen (PSA) test	1.8	2.0	6.5	1.1	1.1	1.8	0.0	-1.3	0.5	-0.1	-2.6	1.2	-1.9	1.5	1.3	1.6
Fractured/broken bones in last 5 years	0.3	0.3	1.3	-0.4	0.6	0.3	0.4	-0.3	1.1	0.6	-1.1	-0.0	-0.8	0.1	-0.4	0.0
Age started oral contraceptive pill	4.6	5.8	12.8	2.5	3.1	3.6	-1.3	-1.1	-2.4	-1.0	-2.2	2.4	-3.3	2.3	2.1	2.5
Diastolic blood pressure, automated reading	0.6	1.9	7.4	-2.2	-0.5	-0.9	0.8	0.7	1.1	-0.2	0.5	-1.9	-0.7	-2.7	-2.0	-0.7
Ever depressed for a whole week	2.5	3.1	8.3	-2.9	-1.7	-2.2	-2.1	-1.2	-0.3	0.4	1.2	-2.6	1.4	-0.9	-0.0	-2.7
Unable to work because of sickness or disability	0.6	0.7	2.8	-0.7	-1.1	-0.7	0.6	0.7	0.3	0.9	1.7	-0.4	1.1	0.1	0.9	-0.6
Commuting to job workplace: Cycle	1.5	1.8	4.0	1.6	0.9	1.7	-0.7	-0.7	1.0	-1.7	-2.0	1.6	-1.6	1.3	1.1	0.1
Myopia	0.3	0.5	2.1	0.8	0.7	0.8	0.3	-0.0	0.9	0.2	-0.0	0.9	-0.2	0.3	-0.8	1.5
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.4	0.3	-0.8	0.1	-0.5	-2.1	-0.8	-0.3	1.8	1.3	0.1	1.8	-0.0	1.0
Cholesterol lowering medication	0.7	1.1	3.6	-1.4	-0.1	-0.9	0.8	1.3	0.5	0.2	-1.5	-1.9	-0.5	-1.3	0.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	6.7	-1.9	-2.1	-2.5	1.1	2.5	0.7	2.1	2.1	-1.2	2.0	-2.6	-0.3	-1.9
Pain experienced in last month	2.4	4.1	15.2	2.5	2.5	1.9	-1.9	-1.3	-1.4	0.6	0.5	2.4	-1.2	2.2	1.4	3.9
Supplements: Calcium	1.2	1.3	7.5	0.3	-0.5	-0.8	0.4	0.7	2.0	0.3	1.4	0.9	2.7	-0.1	0.3	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	3.0	0.4	0.9	1.1	-0.4	-0.7	-1.7	-0.8	-0.2	0.1	-0.8	1.1	-0.0	0.7
Heart attack/myocardial infarction (self-reported)	1.4	1.8	6.4	-1.7	-2.5	-2.4	-0.2	0.9	0.1	-0.3	-0.3	-1.6	0.7	-1.4	-0.4	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	-0.2	-0.4	-0.1	0.3	-0.7	0.2	-0.9	-0.7	-0.4	-0.7	-0.7	-0.8	0.6
Heart disease (siblings)	1.1	1.4	4.6	-1.5	-2.1	-1.2	0.2	-0.3	-1.2	-1.8	0.3	-1.4	0.3	-0.2	0.5	-1.6
Alcohol drinker status: Previous	0.4	0.5	2.8	0.4	-1.7	-0.1	-0.8	-0.1	-0.3	-0.5	-1.2	0.4	-0.0	0.1	-0.6	0.6
Pack years of smoking	0.3	0.5	1.8	-0.2	0.2	-0.3	-1.1	0.7	-1.3	-0.4	-0.7	-0.4	-0.8	-0.6	-0.2	0.9
Impedance of whole body	1.4	7.3	19.9	3.9	4.5	3.4	0.4	2.4	3.8	1.6	2.3	4.0	1.1	1.4	0.3	1.1
Leg fat mass (left)	3.1	12.2	58.8	-5.0	-7.7	-4.9	0.6	0.1	-1.6	-0.4	-2.1	-4.8	0.2	-2.2	-1.0	-3.8
Arm predicted mass (left)	1.2	6.2	31.0	-2.9	-5.6	-2.9	0.0	-2.2	-2.9	-1.7	-2.0	-3.0	-0.4	0.1	-0.2	-1.9