TWAS hub - AFF3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3100	0.0530	0.0e+00	0.237	0.197	0.254	0.247	0.251	1.6e-28	2.0e-23	9.2e-31	9.8e-30	2.7e-30
2	GTEx	Artery Aorta	0.1400	0.0490	1.8e-04	0.058	NA	0.042	NA	0.069	4.1e-04	NA	2.4e-03	NA	1.2e-04
3	GTEx	Artery Tibial	0.0557	0.0252	5.8e-03	0.044	NA	0.040	NA	0.027	2.2e-04	NA	4.3e-04	NA	3.0e-03
4	GTEx	Brain Nucleus accumbens basal ganglia	0.2950	0.1120	2.3e-03	-0.001	NA	-0.008	NA	0.010	3.5e-01	NA	5.8e-01	NA	1.7e-01
5	GTEx	Skin Not Sun Exposed Suprapubic	0.2210	0.0840	4.0e-03	0.018	NA	0.022	NA	-0.001	3.5e-02	NA	2.2e-02	NA	3.6e-01
6	GTEx	Skin Sun Exposed Lower leg	0.0770	0.0370	7.6e-03	0.016	NA	0.017	NA	0.025	1.6e-02	NA	1.5e-02	NA	3.5e-03
7	GTEx	Spleen	0.3880	0.1300	3.2e-03	-0.011	NA	-0.008	NA	-0.010	8.5e-01	NA	6.0e-01	NA	7.1e-01
8	NTR	Blood	0.0290	0.0121	1.6e-03	0.006	0.006	0.003	0.006	0.005	4.7e-03	4.0e-03	3.2e-02	4.1e-03	6.6e-03
9	ROSMAP	Brain Pre-frontal Cortex	0.3066	0.0558	0.0e+00	0.239	0.198	0.252	0.248	0.246	2.0e-30	6.8e-25	3.5e-32	1.5e-31	2.9e-31
10	YFS	Blood	0.0600	0.0162	7.6e-13	0.037	0.048	0.057	0.052	0.056	4.0e-12	2.8e-15	6.2e-18	1.5e-16	8.2e-18
11	TCGA	Brain Lower Grade Glioma	0.0276	0.0141	5.5e-03	0.014	0.015	0.011	NA	0.012	9.2e-03	6.6e-03	2.0e-02	NA	1.4e-02
12	TCGA	Liver Hepatocellular Carcinoma	0.1130	0.0500	1.2e-03	0.010	0.029	-0.001	NA	0.013	1.0e-01	1.6e-02	3.7e-01	NA	7.7e-02
13	TCGA	Prostate Adenocarcinoma	0.0634	0.0289	2.7e-03	-0.002	0.013	0.000	NA	-0.002	8.1e-01	1.4e-02	3.2e-01	NA	7.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Qualifications: College or University degree	8.3	26.3	65.6	6.5	8.1	7.5	-1.2	-3.0	-2.2	-2.0	-1.7	5.8	-4.4	5.4	2.6	8.1
Rheumatoid Arthritis	6.9	9.4	30.2	-3.5	-3.3	-4.5	0.3	0.6	1.4	3.0	4.3	-2.1	5.5	-3.3	-1.0	-1.8
Fluid intelligence score	6.9	14.3	28.4	5.3	4.2	5.3	-0.8	-3.7	-1.0	-1.5	-0.5	4.8	-3.2	5.1	3.5	4.8
Age at First Birth	6.8	9.9	34.1	3.6	4.3	5.8	0.5	-0.0	-0.1	-0.5	-3.5	3.5	-4.3	3.0	1.4	3.1
Intelligence (Savage-Jansen 2018)	6.4	19.8	44.2	6.6	6.2	6.1	0.0	-4.3	-0.4	-2.2	-0.3	6.0	-2.9	5.4	3.2	5.6
Verbal and Numeric Reasoning (VNR)	6.2	14.8	32.4	5.7	5.0	5.4	-0.1	-3.9	-0.8	-1.6	-0.5	5.0	-2.9	4.3	2.3	5.5
Medication: Ventolin 100micrograms inhaler	6.1	7.9	23.4	-3.9	-3.1	-3.9	-0.8	0.3	2.2	0.8	0.7	-3.8	1.6	-4.8	-3.7	-1.2
Wheeze or whistling in the chest in last year	5.1	9.0	20.4	-4.5	-3.7	-4.4	-1.0	-0.4	0.3	2.0	1.8	-3.8	2.7	-4.3	-2.5	-2.9
Qualifications: None of the above	5.0	10.8	27.1	-3.8	-4.1	-4.4	2.6	3.7	1.3	2.7	0.4	-3.1	2.3	-3.8	-1.8	-5.2
Alcohol usually taken with meals	4.9	8.0	22.2	3.1	4.7	4.2	-0.8	-1.3	-1.7	-1.5	-2.2	2.2	-3.5	3.1	2.4	2.9
Mouth/teeth dental problems: Mouth ulcers	4.8	7.6	21.0	-3.3	-1.7	-4.0	-0.1	0.9	1.3	2.1	3.7	-2.7	4.6	-2.7	-1.3	-3.3
Asthma	4.7	9.3	31.0	-4.3	-3.3	-4.2	-1.2	0.6	1.4	-0.6	0.4	-4.3	1.6	-5.6	-3.8	-1.9
Age started oral contraceptive pill	4.6	5.8	12.8	2.5	3.1	3.6	-1.3	-1.1	-2.4	-1.0	-2.2	2.4	-3.3	2.3	2.1	2.5
Angina	4.5	5.9	15.9	-2.8	-2.6	-3.2	0.3	1.7	1.8	-1.0	-0.4	-3.2	1.0	-4.0	-3.1	-2.8
Commuting to job workplace: Public transport	4.5	5.4	17.8	2.7	4.2	3.3	-0.9	-2.0	-0.8	-0.1	1.3	2.1	-2.2	2.2	1.0	3.5
Angina (self-reported)	4.4	5.7	15.0	-2.7	-2.6	-3.0	0.5	1.6	1.7	-1.4	-0.6	-3.3	0.7	-3.9	-3.0	-2.8
Asthma (self-reported)	4.3	8.5	27.1	-4.1	-3.3	-4.2	-1.4	0.7	1.1	-0.4	0.5	-4.1	1.8	-5.2	-3.4	-1.6
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.3	17.2	-3.9	-4.1	-3.6	-0.5	-0.4	0.5	-0.3	-0.1	-3.2	1.3	-2.4	-1.1	-4.2
Qualifications: CSEs or equivalent	3.8	5.0	12.0	-2.8	-2.5	-3.5	0.5	0.3	1.8	1.4	1.0	-1.6	2.7	-3.0	-2.6	-2.6
Number of full sisters	3.7	4.4	17.3	-3.4	-1.8	-2.1	0.2	0.6	2.0	0.0	0.1	-4.2	-0.4	-2.8	-2.6	-1.3
Headache pain in last month	3.5	6.0	11.3	-3.1	-3.4	-3.0	1.8	0.2	1.5	-1.5	0.5	-2.9	2.2	-3.2	-2.6	-3.1
Hair/balding pattern: Pattern 3	3.3	4.9	13.9	3.2	3.2	3.2	0.6	0.1	-0.2	-1.3	-1.0	2.8	-2.0	1.8	0.4	3.7
Blood Red Count	3.2	31.1	83.6	-7.3	-4.7	-9.1	1.2	1.2	2.1	2.2	5.6	-5.1	7.2	-9.0	-4.9	-4.2
Body mass index (BMI)	3.2	13.8	56.9	-5.5	-7.5	-5.2	0.8	-0.0	-1.8	-0.4	-2.3	-5.5	-0.2	-3.0	-1.6	-3.7
Leg fat percentage (right)	3.2	11.7	46.8	-4.9	-6.8	-5.0	1.7	1.2	-0.0	1.0	-1.4	-4.2	1.4	-3.1	-1.2	-4.3
Average weekly red wine intake	3.2	4.7	7.4	2.0	1.8	2.7	-1.8	-2.6	-2.6	-1.7	-1.5	2.0	-2.3	2.7	2.2	1.8
Financial difficulties in last 2 years	3.1	4.1	20.8	-2.7	-4.6	-2.4	0.6	-0.1	1.8	0.1	-1.2	-3.0	-0.6	-1.5	-1.3	-1.2
Leg fat mass (right)	3.1	12.0	58.7	-5.0	-7.7	-4.8	0.9	0.1	-1.3	-0.1	-2.1	-4.7	0.4	-2.3	-1.0	-3.8
Leg fat mass (left)	3.1	12.2	58.8	-5.0	-7.7	-4.9	0.6	0.1	-1.6	-0.4	-2.1	-4.8	0.2	-2.2	-1.0	-3.8
Waist circumference	3.0	11.1	49.0	-4.8	-7.0	-4.4	0.1	0.4	0.3	-0.8	-2.1	-5.0	-0.2	-2.9	-3.0	-2.4
Qualifications: A levels/AS levels or equivalent	3.0	6.7	21.2	3.5	4.6	3.5	0.3	-2.2	1.5	-2.1	-0.5	2.7	-1.7	0.8	-1.2	4.1
Medication: Omeprazole	3.0	3.5	6.8	-1.7	-2.1	-2.1	1.6	2.3	0.7	2.6	1.8	-1.0	2.3	-1.8	0.4	-2.3
Leg fat percentage (left)	3.0	11.0	45.6	-4.7	-6.8	-4.9	1.4	1.4	-0.4	0.6	-1.4	-4.2	1.2	-2.8	-1.2	-4.1
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	6.7	-1.9	-2.1	-2.5	1.1	2.5	0.7	2.1	2.1	-1.2	2.0	-2.6	-0.3	-1.9
BMI	2.9	16.8	76.9	-5.4	-8.8	-5.3	0.6	0.8	-1.8	-1.0	-4.3	-5.8	-1.5	-2.6	-1.7	-3.9
Mother’s age at death	2.9	3.6	10.7	2.2	3.3	2.8	-0.8	-0.1	-1.2	-0.8	-1.4	1.2	-2.5	1.6	0.3	3.0
Waist Hip Ratio (WHR)	2.8	12.8	51.4	-3.5	-2.1	-2.6	1.2	1.5	7.2	2.1	1.3	-3.8	1.7	-4.8	-6.3	-1.5
Hypothyroidism (self reported)	2.7	6.1	20.2	-3.7	-2.9	-4.5	-1.2	0.9	-1.1	1.9	1.3	-3.5	1.8	-2.8	-1.0	-2.1
Father’s age at death	2.7	3.6	11.4	2.9	2.7	2.3	0.5	-0.8	-0.3	1.3	0.6	3.4	-0.5	2.0	1.3	2.3
Noisy workplace	2.7	3.3	7.7	-1.9	-2.7	-1.7	-0.1	1.4	-1.1	-1.2	-2.4	-2.5	-1.0	-1.5	-1.0	-2.8
Arm fat mass (left)	2.7	11.0	51.8	-4.6	-7.2	-4.4	0.6	-0.2	-1.7	-0.9	-2.4	-4.7	-0.4	-2.0	-1.2	-3.5
Schizophrenia vs Biploar Disorder	2.6	3.4	12.6	-0.1	0.5	0.4	0.4	2.9	2.5	-0.6	-2.0	-0.5	-1.9	-2.8	-3.5	0.4
Hypothyroidism/myxoedema (self-reported)	2.6	5.1	19.6	-2.9	-2.4	-4.4	0.2	1.4	-0.3	1.6	1.0	-2.9	1.9	-3.1	-1.5	-1.7
Alcohol intake frequency.	2.6	6.0	17.0	-3.7	-2.9	-2.7	0.8	1.6	0.8	-1.1	-1.7	-4.1	-0.3	-3.4	-2.6	-2.6
Guilty feelings	2.6	3.9	7.1	1.9	1.4	2.3	0.6	-1.1	-2.5	-1.6	-2.7	1.1	-2.6	2.1	2.3	1.8
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	11.2	-2.1	-3.4	-2.0	-1.7	-1.4	-1.7	-0.9	1.3	-1.9	1.0	-0.1	0.6	-2.1
Arm fat mass (right)	2.5	10.4	47.7	-4.5	-6.9	-4.2	0.5	-0.2	-1.9	-0.9	-2.5	-4.7	-0.8	-1.8	-1.0	-3.4
Medication for pain relief, constipation, heartburn	2.5	4.3	13.3	2.4	1.7	2.2	-1.5	-1.1	-2.0	-0.4	1.0	2.3	0.3	3.6	3.7	1.4
Medication: Seretide 50 evohaler	2.5	2.9	11.3	-1.9	-0.7	-1.7	-0.8	0.9	1.5	0.9	1.3	-1.6	1.3	-3.4	-2.9	-0.3
Ever depressed for a whole week	2.5	3.1	8.3	-2.9	-1.7	-2.2	-2.1	-1.2	-0.3	0.4	1.2	-2.6	1.4	-0.9	-0.0	-2.7
Worry (Nagel 2018)	2.4	5.1	21.8	2.2	4.7	3.0	2.2	1.4	1.0	-0.9	-2.9	1.9	-2.3	0.2	-0.4	2.2
Respiratory disease	2.4	5.4	15.4	-3.2	-3.1	-3.3	-2.2	0.9	-0.8	-1.1	0.4	-3.2	1.4	-3.9	-1.9	-0.9
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	16.3	-0.7	1.5	-0.1	-1.2	-1.4	1.7	-2.5	0.7	-1.0	-0.5	-2.6	-4.0	3.1
Pain experienced in last month	2.4	4.1	15.2	2.5	2.5	1.9	-1.9	-1.3	-1.4	0.6	0.5	2.4	-1.2	2.2	1.4	3.9
Overall health rating	2.3	5.0	11.7	-3.3	-2.7	-2.6	0.6	1.6	1.4	-0.3	-0.2	-2.8	0.6	-3.4	-2.5	-3.0
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	7.7	-1.6	-2.5	-2.3	-1.6	0.7	-0.5	0.7	1.4	-1.6	2.1	-0.1	1.3	-2.8
Commuting to job workplace: Car/motor vehicle	2.3	2.7	7.8	-1.0	-1.8	-1.7	2.0	2.8	1.6	1.1	0.1	-0.7	2.4	-1.4	-0.7	-1.8
Arm fat percentage (left)	2.3	9.2	38.7	-4.4	-6.2	-4.0	1.3	0.7	-0.6	-0.1	-2.0	-4.4	-0.3	-2.5	-1.4	-3.5
Ulcerative Colitis	2.2	3.1	10.5	-1.7	1.1	-2.6	-0.3	1.7	-0.7	1.5	2.8	-0.8	3.2	-2.1	-0.9	0.2
Allergy	2.2	5.2	21.2	2.4	1.5	2.3	0.2	-1.9	-2.3	1.4	0.2	2.1	-0.8	4.6	4.0	0.7
Diabetes (self-reported)	2.2	3.4	10.4	-2.9	-2.5	-2.4	-1.1	0.6	1.5	-0.1	0.3	-3.2	-0.0	-2.6	-0.9	-1.6
Arm fat percentage (right)	2.2	8.7	34.8	-4.3	-5.9	-3.9	1.4	0.4	-0.8	0.0	-1.9	-4.4	-0.4	-2.3	-1.3	-3.5
Whole body fat mass	2.2	9.0	46.6	-4.1	-6.8	-3.8	0.4	0.2	-1.7	-0.7	-2.3	-4.1	-0.4	-1.4	-0.8	-3.3
Medication: Paracetamol	2.2	3.4	10.5	-1.9	-1.3	-1.5	0.4	1.6	2.0	-0.7	-0.0	-2.2	-0.0	-3.0	-3.2	-2.2
Prostate Cancer	2.1	3.0	7.3	-2.0	-0.7	-2.5	-0.6	1.0	1.1	1.6	1.9	-1.6	2.0	-2.7	-0.9	-2.2
Hand grip strength (left)	2.1	5.6	19.0	3.7	2.1	2.5	-0.3	-1.1	-1.1	-2.0	-0.3	4.3	-0.2	2.0	-0.2	4.4
Medication: Paracetamol	2.1	3.5	12.4	-2.2	-2.0	-1.9	0.7	1.0	1.9	-0.4	0.0	-2.2	-0.3	-2.7	-3.5	-1.7
Severe depression (siblings)	2.0	2.2	4.3	1.8	2.0	1.9	0.1	0.6	-0.2	0.9	-2.1	1.3	-1.4	1.4	2.0	1.6
Fed-up feelings	2.0	3.7	14.8	-2.3	-3.9	-3.0	-0.0	1.5	0.8	-0.1	-1.1	-1.8	0.7	-1.4	-0.7	-3.0
Body fat percentage	2.0	7.9	36.4	-3.7	-6.0	-3.7	1.2	1.6	-0.4	0.4	-1.7	-3.6	0.3	-2.1	-1.1	-3.6
Neck or shoulder pain in last month	2.0	2.8	7.3	-2.7	-1.1	-1.7	-0.3	1.7	0.9	-0.9	0.8	-2.4	1.2	-1.8	-1.5	-2.6
Leg pain on walking	2.0	2.5	6.8	-1.7	-1.5	-2.2	-0.0	0.8	0.9	-0.2	0.2	-2.2	0.4	-2.1	-2.1	-2.6
Commuting to job workplace: Walk	2.0	2.2	5.6	0.8	2.4	1.4	-2.1	-1.6	-1.8	-0.8	-0.2	0.4	-1.4	1.2	1.1	2.2
Ulcerative Colitis (UC)	1.9	3.5	8.2	-2.6	-0.3	-2.5	-0.5	1.4	-0.2	2.0	2.2	-1.7	2.2	-2.9	-2.2	0.3
Major Depression (MDD)	1.9	2.3	6.1	-1.7	-1.3	-1.8	-0.8	1.5	-0.4	1.7	0.8	-1.6	2.3	-1.0	1.0	-2.5
Smoking Status	1.9	4.4	13.4	0.0	-2.4	-0.6	3.7	2.0	2.4	3.3	0.2	0.4	1.5	0.7	1.4	-3.5
Taking other prescription medications	1.9	3.0	6.7	-1.8	-1.4	-2.5	0.4	1.0	1.9	1.2	1.1	-1.7	1.7	-2.2	-1.5	-2.6
Weight	1.9	9.3	47.7	-3.9	-6.9	-3.7	-0.3	-1.4	-2.4	-1.9	-2.6	-4.1	-0.8	-1.0	-1.0	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	5.6	2.4	1.1	1.8	-0.5	0.9	-1.6	-1.3	-0.4	2.2	-0.3	2.0	2.0	0.1
Chest pain or discomfort	1.9	2.7	9.3	-2.0	-1.5	-1.7	0.8	-0.4	-0.6	-1.2	-1.4	-3.0	-0.2	-1.9	-0.1	-2.9
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	5.5	1.2	0.4	-0.1	-2.3	-2.1	-2.1	-1.0	1.4	1.8	1.0	1.3	0.7	1.0
Stomach or abdominal pain in last month	1.8	2.2	6.1	-2.2	-1.1	-1.6	-0.3	0.2	-0.5	-2.1	-0.6	-2.5	-0.1	-1.5	-1.5	-2.0
Hip circumference	1.8	7.8	39.3	-3.0	-6.3	-3.2	-1.0	-0.6	-3.7	-2.1	-2.8	-3.2	-0.7	0.1	0.6	-2.0
Mouth/teeth dental problems: Dentures	1.8	3.0	9.3	0.9	1.0	1.3	-0.5	0.5	-2.7	-2.3	-3.1	-1.0	-2.5	1.5	1.7	-0.6
Medication: Aspirin	1.8	2.3	8.5	-1.9	-1.5	-1.5	-0.1	-1.0	-0.0	-0.6	-1.5	-1.9	-0.0	-2.5	-2.9	-0.4
Ever had prostate specific antigen (PSA) test	1.8	2.0	6.5	1.1	1.1	1.8	0.0	-1.3	0.5	-0.1	-2.6	1.2	-1.9	1.5	1.3	1.6
Breastfed as a baby	1.7	2.1	5.2	1.8	0.3	1.2	-0.6	-0.0	-2.1	-0.0	0.9	2.3	0.7	2.3	1.7	1.6
Long-standing illness, disability or infirmity	1.7	2.6	7.2	-1.4	-0.5	-1.8	0.1	0.8	2.6	0.1	-0.1	-2.2	0.5	-2.6	-1.5	-2.7
Diabetes diagnosed by doctor	1.7	2.9	8.6	-2.6	-1.8	-2.1	-0.5	1.2	1.8	0.8	-0.2	-2.9	-0.3	-2.4	-0.8	-1.4
Risk taking	1.7	2.5	7.8	0.8	0.2	1.2	-1.6	1.6	-2.8	0.6	-0.8	0.7	-1.0	2.6	2.7	0.6
Bipolar Disorder (2018)	1.6	2.5	9.4	1.1	-0.2	0.3	2.6	0.5	0.6	3.1	0.9	1.3	1.2	1.7	2.8	-0.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.4	1.5	1.6	2.3	2.0	0.3	0.9	-0.8	-1.9	0.9	-1.7	1.4	1.2	-0.9
Trunk fat percentage	1.6	6.3	30.5	-3.2	-5.5	-3.1	0.7	1.7	-0.4	0.2	-1.7	-3.3	0.1	-1.6	-1.1	-3.1
Current tobacco smoking	1.6	2.6	9.4	-2.1	-2.0	-1.5	1.8	0.0	0.7	1.8	1.0	-2.2	0.6	-0.8	0.2	-3.1
Hayfever, allergic rhinitis or eczema	1.6	3.5	11.8	-0.9	0.4	-0.9	1.7	2.2	3.4	-0.6	-0.7	-0.4	0.6	-3.3	-3.4	-0.2
Trunk fat mass	1.6	6.8	38.7	-3.4	-6.2	-3.2	0.4	0.4	-1.3	-0.4	-2.1	-3.4	-0.3	-1.0	-0.7	-2.9
Falls in the last year	1.6	2.1	6.1	-2.5	-1.6	-1.5	-0.7	0.1	-0.0	-2.1	1.0	-2.1	0.4	-1.4	-1.1	-1.9
Smoking status: Current	1.6	2.5	8.7	-1.8	-2.2	-1.5	1.9	0.1	0.9	1.7	1.4	-1.8	0.9	-0.7	0.2	-2.9
Supplements: Fish oil (including cod liver oil)	1.6	2.1	4.2	1.3	1.2	0.8	1.5	-1.7	-0.1	1.3	1.6	2.1	1.9	1.8	2.0	-0.3
Fasting Glucose	1.5	1.8	4.7	-1.1	-1.0	-2.2	0.3	2.1	2.0	-0.3	1.0	-1.0	1.4	-1.6	-1.1	-0.6
Type 2 Diabetes (T2D) (2018)	1.5	2.9	9.4	-2.4	-1.4	-1.8	-0.2	0.5	2.4	1.1	-0.4	-3.1	-0.2	-2.5	-1.1	-1.3
Age when periods started (menarche)	1.5	3.6	14.1	0.6	-0.8	1.3	-1.7	-0.4	-0.9	2.4	1.6	1.1	1.4	3.8	3.7	-1.2
Supplements: Glucosamine	1.5	1.9	7.3	1.4	0.3	1.2	1.2	-0.9	-0.4	1.2	0.4	1.4	1.5	2.5	2.7	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	9.5	1.1	1.4	2.4	0.7	0.4	-1.9	-0.3	-3.1	-0.2	-2.6	2.3	3.0	-1.4
Pain all over the body in last month	1.5	1.6	5.0	-2.2	-0.9	-0.9	-0.8	1.3	1.5	0.3	-0.1	-2.0	-0.1	-1.5	-1.1	-1.3
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	8.5	-1.1	-0.0	-0.8	-0.8	1.3	2.9	1.3	1.1	-0.3	0.6	-2.2	-2.1	-0.1
Impedance of arm (right)	1.5	7.2	24.4	4.2	4.9	4.2	0.6	0.9	2.7	0.8	1.5	3.6	-0.5	2.3	0.9	1.8
Impedance of arm (left)	1.5	6.8	23.1	4.1	4.8	4.0	-0.1	1.3	2.9	0.4	1.2	3.6	-0.5	1.9	0.5	1.9
Illnesses of siblings: Diabetes	1.5	1.9	5.6	-1.1	-2.4	-2.0	1.3	0.8	0.5	0.6	1.3	-0.9	1.7	-1.6	-0.8	-1.3
Qualifications: nursing, teaching	1.5	2.3	6.1	1.6	2.0	2.3	0.0	-2.0	-0.7	-1.5	-0.4	1.2	-1.4	1.4	0.0	2.5
Mineral and other dietary supplements	1.5	2.1	6.2	-1.7	-1.1	-0.5	-1.4	0.8	-0.4	-1.4	-1.1	-2.1	-2.5	-1.7	-1.8	0.1
Commuting to job workplace: Cycle	1.5	1.8	4.0	1.6	0.9	1.7	-0.7	-0.7	1.0	-1.7	-2.0	1.6	-1.6	1.3	1.1	0.1
Impedance of leg (right)	1.4	6.6	17.1	2.6	3.2	1.7	0.9	2.8	4.1	3.1	2.8	3.5	3.1	0.3	0.4	-0.3
Leg fat-free mass (left)	1.4	7.5	29.4	-2.7	-5.4	-2.1	-1.0	-2.9	-3.5	-3.0	-2.9	-3.3	-2.0	0.6	-0.2	-1.1
Hand grip strength (right)	1.4	3.8	14.8	2.6	1.7	1.8	-1.4	-1.0	-1.7	-2.5	-0.2	2.8	-0.7	1.1	-0.7	3.9
Impedance of leg (left)	1.4	6.7	16.0	3.0	3.5	1.9	0.8	3.2	4.0	2.7	2.5	3.7	2.7	0.5	0.2	-0.0
Leg predicted mass (left)	1.4	7.5	29.5	-2.7	-5.4	-2.1	-1.1	-2.9	-3.6	-3.0	-2.8	-3.4	-2.0	0.6	-0.2	-1.0
Mouth/teeth dental problems	1.4	2.1	7.8	1.5	1.3	1.4	0.7	-0.1	1.8	1.2	0.2	2.8	-0.5	-0.5	-1.5	2.5
Exposure to tobacco smoke at home	1.4	1.6	4.7	-0.9	-0.0	-0.7	2.1	0.3	2.2	0.5	-0.1	-1.3	0.0	-1.9	-2.1	-0.6
Knee pain experienced in last month	1.4	2.1	9.2	-1.6	-0.8	-1.6	1.6	1.1	0.5	0.0	-0.9	-2.6	0.0	-1.0	-0.1	-3.0
Leg fat-free mass (right)	1.4	7.3	24.9	-2.4	-5.0	-1.8	-1.3	-2.9	-3.6	-3.5	-3.0	-3.2	-2.4	0.7	-0.5	-0.7
Leg predicted mass (right)	1.4	7.3	24.7	-2.3	-5.0	-1.7	-1.3	-3.0	-3.7	-3.5	-3.0	-3.1	-2.4	0.8	-0.4	-0.6
Heart attack/myocardial infarction (self-reported)	1.4	1.8	6.4	-1.7	-2.5	-2.4	-0.2	0.9	0.1	-0.3	-0.3	-1.6	0.7	-1.4	-0.4	-1.6
Impedance of whole body	1.4	7.3	19.9	3.9	4.5	3.4	0.4	2.4	3.8	1.6	2.3	4.0	1.1	1.4	0.3	1.1
Alzheimer’s Disease (in mother)	1.3	1.5	4.4	1.3	1.2	2.1	1.5	-1.1	-0.2	-0.0	-1.1	1.6	-0.2	1.8	1.1	-0.1
Average weekly spirits intake	1.3	1.6	5.8	-0.4	-0.6	0.7	0.8	1.7	-0.3	-2.0	-2.4	-1.3	-1.8	-0.0	0.5	-0.9
Medication for hormone replacement therapy	1.3	1.4	4.0	1.6	0.4	2.0	1.1	-0.0	-0.7	-0.8	-1.1	1.0	-1.4	1.8	1.0	0.8
Medication: Levothyroxine sodium	1.3	2.2	8.2	-2.1	-2.2	-2.9	0.4	0.4	-0.5	1.5	-0.0	-2.1	0.5	-1.6	-0.4	-1.1
Sitting height	1.3	9.2	25.8	2.1	0.0	2.3	-3.5	-4.1	-4.0	-5.1	-2.2	1.6	-3.1	3.4	1.0	3.0
Chronic bronchitis/emphysema (father)	1.3	1.6	3.6	0.6	0.5	1.6	0.6	-1.5	-1.6	-1.6	-1.0	-0.1	-1.8	1.9	1.4	0.2
Nervous feelings	1.3	2.4	6.0	2.2	2.4	1.9	1.1	1.3	-0.0	-1.9	-1.2	2.5	-0.3	0.3	-0.4	1.6
Heart attack	1.3	1.7	6.3	-1.5	-2.5	-2.4	-0.2	0.8	-0.2	-0.6	-0.5	-1.5	0.6	-1.1	-0.1	-1.6
Lung cancer (father)	1.3	1.5	4.2	-1.4	-0.7	-2.0	0.1	-0.5	-0.4	0.0	1.5	-1.1	1.6	-1.7	-1.9	-0.1
Loud music exposure frequency	1.3	1.4	3.8	-1.8	-0.7	-0.7	-1.5	-0.9	-1.3	0.0	-1.4	-1.9	-1.0	-0.2	0.6	-1.3
Age at first live birth	1.3	2.3	6.6	1.0	2.1	2.4	-0.8	-1.3	-1.1	-1.9	0.7	1.2	-1.3	1.1	-0.4	2.6
Medication: Aspirin	1.3	1.8	8.5	-1.4	-0.5	-1.1	0.4	-0.7	0.2	-0.5	-1.6	-1.3	-0.3	-2.4	-2.9	0.1
Medication for cholesterol	1.3	2.0	11.3	-0.1	-0.5	-1.0	-0.9	-2.0	-1.0	0.9	3.4	1.0	2.1	1.0	-0.2	0.2
Hearing aid user	1.3	1.5	4.2	1.4	0.8	2.0	1.7	0.8	1.1	0.2	-1.7	1.2	-0.4	-0.5	-1.4	1.0
Basal metabolic rate	1.3	7.3	31.7	-2.9	-5.6	-2.5	-0.7	-2.9	-3.4	-2.6	-2.6	-3.2	-1.4	0.5	-0.1	-1.4
Arm fat-free mass (left)	1.3	6.4	32.8	-2.7	-5.7	-2.8	-0.2	-2.3	-3.1	-2.1	-2.1	-2.7	-0.5	0.3	0.1	-1.8
Bipolar Disorder (2011)	1.2	1.2	5.5	0.1	0.3	0.1	0.4	0.3	-2.1	1.1	0.3	0.6	0.2	1.7	2.4	0.9
Number of treatments/medications taken	1.2	2.2	5.7	-1.1	-0.5	-0.9	0.9	2.4	2.4	0.9	-1.2	-1.6	-0.3	-2.1	-1.2	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	5.0	-2.2	-1.8	-1.6	-0.7	-0.2	-0.4	0.4	0.2	-1.9	0.5	-1.3	-1.0	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	6.7	0.8	0.4	1.9	0.6	-0.3	-2.4	-1.0	-2.5	-0.5	-2.2	2.1	2.6	-1.5
Multivitamins +/- minerals	1.2	1.5	4.6	1.5	2.1	2.1	0.8	-0.3	0.5	-1.1	-0.7	1.1	-1.0	0.9	-0.6	1.7
Medication: Atenolol	1.2	1.5	3.3	-1.2	-1.0	-1.3	-0.6	1.5	-0.5	-1.4	-1.2	-1.7	0.1	-1.8	-0.5	-1.8
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	13.9	2.0	-0.0	0.2	0.3	-2.9	-0.5	0.8	2.4	2.8	3.7	2.8	2.2	-0.7
Pulse wave Arterial Stiffness index	1.2	1.4	4.7	0.1	-0.5	-0.0	-1.5	1.2	-1.8	-2.2	-1.7	0.4	-0.8	-0.5	-0.3	1.5
Tense / ‘highly strung’	1.2	2.0	6.2	2.0	2.5	1.4	-0.0	1.6	0.2	-0.6	-1.7	2.1	-0.6	1.6	0.8	0.6
Arm fat-free mass (right)	1.2	6.1	31.2	-2.6	-5.6	-2.6	-0.5	-2.2	-3.1	-2.1	-2.3	-2.6	-0.6	0.3	-0.0	-1.6
Number of full brothers	1.2	1.6	4.4	-2.0	-1.6	-2.0	-0.4	-0.4	-1.0	0.4	0.3	-2.1	0.6	-1.0	-0.5	-1.5
Suffer from ‘nerves’	1.2	1.8	5.6	0.6	2.4	1.0	1.6	1.0	0.2	-2.1	-1.3	-0.2	-1.2	-1.2	-1.8	1.2
Loneliness, isolation	1.2	1.6	5.4	-1.6	-0.3	-1.3	0.0	1.5	1.2	0.1	0.7	-1.3	0.2	-2.3	-2.3	-0.4
Ever had bowel cancer screening	1.2	1.5	4.0	1.2	0.9	1.5	1.3	-0.5	-0.6	-0.8	-1.2	1.0	-1.4	1.6	2.0	0.7
Osteoarthritis (self-reported)	1.2	1.5	6.0	-0.0	0.1	0.3	-0.4	0.3	-1.7	-1.1	-2.5	-0.8	-1.6	0.8	1.9	-1.4
Whole body water mass	1.2	6.6	25.2	-2.4	-5.0	-2.0	-0.7	-3.3	-3.7	-2.7	-2.5	-2.8	-1.5	1.0	0.3	-0.9
Supplements: Calcium	1.2	1.3	7.5	0.3	-0.5	-0.8	0.4	0.7	2.0	0.3	1.4	0.9	2.7	-0.1	0.3	-0.8
Arm predicted mass (left)	1.2	6.2	31.0	-2.9	-5.6	-2.9	0.0	-2.2	-2.9	-1.7	-2.0	-3.0	-0.4	0.1	-0.2	-1.9
Primary Biliary Cirrhosis	1.1	1.6	4.6	-1.3	-0.6	-1.8	0.4	-0.0	0.9	1.3	1.9	-0.2	2.1	-2.0	-0.7	-0.1
Systolic Blood Pressure	1.1	5.5	13.5	-2.5	0.2	-2.1	0.1	2.3	3.2	2.4	2.8	-1.8	2.7	-3.7	-2.0	-1.8
Lung FEV1/FVC ratio	1.1	5.7	19.7	-1.7	-1.3	-2.2	3.5	-2.2	1.1	2.0	2.7	-1.7	2.7	0.6	2.0	-4.4
Medication: Co-codamol	1.1	1.3	3.2	-1.2	-0.0	-1.7	1.0	-0.2	1.3	1.1	1.0	-1.8	0.9	-1.2	-0.2	-1.3
Medication: Metformin	1.1	1.5	3.6	-1.9	-1.2	-1.6	-0.1	0.8	1.7	1.7	-0.1	-1.9	-0.1	-1.4	-0.4	-0.8
Diabetes (mother)	1.1	1.4	4.0	-0.9	-0.2	0.2	1.9	-0.0	2.0	0.0	-1.1	-1.7	-1.1	-1.0	-1.4	-1.1
Maternal smoking around birth	1.1	1.6	8.6	-0.4	-2.1	-1.2	0.5	-0.0	-0.1	0.9	1.0	-0.5	1.4	0.4	1.3	-2.9
Had other major operations	1.1	1.3	5.0	-1.0	-0.7	-1.1	0.5	1.1	-0.8	-0.3	1.1	-1.3	1.4	-0.2	1.5	-2.2
Forced vital capacity (FVC)	1.1	4.1	13.5	2.9	0.3	1.0	-0.3	-2.4	-1.0	0.2	1.4	3.7	2.7	3.2	1.9	0.7
Alcohol intake versus 10 years previously	1.1	1.6	4.6	-1.6	-2.1	-2.1	0.3	0.0	0.2	-0.2	0.3	-2.0	0.1	-1.7	-1.4	-0.6
Worrier / anxious feelings	1.1	2.1	6.3	1.1	2.5	2.0	0.6	0.1	-0.7	-1.7	-2.3	1.0	-2.0	0.2	0.4	1.1
Hair/balding pattern: Pattern 4	1.1	2.7	5.4	2.3	2.2	2.0	2.2	1.3	-0.3	0.6	-0.6	2.2	0.1	2.0	2.1	0.2
Pulse wave peak to peak time	1.1	1.2	3.4	0.1	0.7	0.3	1.4	-1.4	1.6	1.9	1.6	-0.2	0.6	0.9	0.5	-1.3
Eye problems/disorders: None of the above	1.1	1.3	5.9	-0.4	-0.3	-1.5	0.4	0.4	0.3	1.1	1.4	0.3	2.4	-1.2	-0.0	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	6.9	1.9	0.7	1.0	0.6	0.6	-0.3	-0.9	0.0	2.6	0.2	0.3	-0.7	1.6
Arm predicted mass (right)	1.1	5.8	30.1	-2.4	-5.5	-2.5	-0.5	-2.1	-3.0	-2.1	-2.4	-2.5	-0.6	0.4	-0.0	-1.5
Age at last live birth	1.1	1.5	7.0	0.2	1.4	1.0	-0.9	-1.6	-1.3	-1.2	1.4	0.7	0.2	-0.0	-1.0	2.6
Whole body fat-free mass	1.1	6.5	24.9	-2.3	-5.0	-1.9	-0.8	-3.2	-3.7	-2.8	-2.6	-2.7	-1.5	1.1	0.4	-0.9
Friendships satisfaction	1.1	1.4	7.2	0.8	1.7	1.6	-0.1	-1.1	0.7	-0.0	1.0	0.6	-0.6	1.1	-0.6	2.7
Number of self-reported non-cancer illnesses	1.1	2.0	5.1	-1.6	-0.9	-1.2	-0.3	1.8	1.1	0.0	-1.3	-2.1	-0.1	-2.3	-0.5	-2.0
Average weekly champagne plus white wine intake	1.1	1.5	4.2	0.4	0.0	1.4	-1.9	-1.6	-0.5	-1.2	2.0	0.6	-0.7	1.7	1.3	-0.2
Heart disease (siblings)	1.1	1.4	4.6	-1.5	-2.1	-1.2	0.2	-0.3	-1.2	-1.8	0.3	-1.4	0.3	-0.2	0.5	-1.6
Neuroticism (Nagel 2018)	1.0	2.3	9.1	1.4	1.6	1.3	1.0	2.4	-0.1	-1.2	-3.0	1.3	-1.6	0.8	0.9	0.3
Alzheimer’s Disease (in father)	1.0	1.1	3.5	-1.4	-0.5	-0.7	-1.0	-0.3	0.9	1.9	1.1	-0.6	0.3	-1.6	-1.5	-0.1
Lung FVC	1.0	5.3	19.8	2.1	1.3	-0.8	-0.1	-1.9	-2.1	2.2	3.0	2.7	4.5	2.0	3.1	0.2
Serious illness, injury or assault to yourself	1.0	1.2	6.2	-0.4	-0.9	-1.2	0.9	1.9	0.5	0.5	-0.2	-0.2	1.1	-0.6	0.7	-2.5
Medication: Ramipril	1.0	1.2	3.5	-1.5	-0.2	-0.4	0.1	-1.1	0.9	-0.6	-0.9	-1.9	-1.1	-1.6	-1.8	0.0
Time employed in main current job	1.0	1.2	2.8	1.2	1.4	1.6	-0.0	-1.7	-0.5	-0.5	-0.5	1.3	-1.0	1.4	0.5	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	10.8	1.7	0.1	0.1	0.2	-3.0	-0.2	0.3	1.9	2.4	3.3	2.4	2.0	-1.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	5.3	-1.5	-2.3	-0.8	-0.7	-0.6	-0.6	-1.1	-0.9	-1.9	-0.6	0.2	0.4	-0.7
Forced vital capacity (FVC), Best measure	1.0	3.7	11.6	2.9	0.9	1.1	-0.3	-2.5	-0.8	-0.2	0.9	3.4	2.4	2.9	2.0	0.2
Mouth/teeth dental problems: Loose teeth	1.0	1.1	4.5	0.3	-0.2	0.4	-0.1	-1.3	-1.6	-0.8	0.6	-0.2	0.5	2.1	1.9	-0.8
Smoking status: Previous	1.0	1.5	5.3	1.5	-0.3	0.7	2.3	0.8	1.3	1.4	-0.5	1.7	0.6	1.6	0.9	-0.8
Pain type(s) experienced in last month: Hip pain	1.0	1.3	5.0	-1.5	-1.0	-1.0	-0.4	0.1	-0.2	-0.3	-1.2	-1.9	-0.4	-1.0	-1.2	-2.2
Medication: Atorvastatin	1.0	1.2	4.5	-0.5	-0.9	-1.3	0.9	2.1	0.2	-0.1	-0.4	-0.6	-0.4	-2.1	-1.6	0.5
Mean Putamen Volume	0.9	1.1	5.0	-0.6	-1.4	-1.3	-2.2	0.3	0.6	0.1	0.7	-0.5	0.6	-0.3	0.1	-1.8
Neuroticism (2016)	0.9	1.4	3.4	1.2	0.5	1.7	1.0	0.3	-0.8	-0.0	-1.1	1.5	-0.7	1.8	1.8	0.7
Allergy or Eczema	0.9	2.4	7.6	-0.4	1.3	-0.1	2.2	1.1	2.8	-0.9	-1.2	-0.5	-0.7	-2.4	-2.7	0.2
Relative age of first facial hair	0.9	1.9	4.3	-1.7	-2.0	-1.9	-1.0	0.8	0.4	-0.0	0.9	-2.1	1.0	-1.6	-0.6	-1.6
Ever had hysterectomy (womb removed)	0.9	1.0	4.2	-1.2	-1.2	-1.3	0.8	0.9	0.5	0.2	-0.3	-1.0	0.7	-0.7	0.8	-2.1
Systolic blood pressure, automated reading	0.9	2.6	9.3	-3.0	-1.0	-1.8	0.5	0.9	1.2	1.1	1.0	-2.4	0.8	-2.9	-1.0	-0.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.2	-1.0	-0.6	-0.0	-1.2	-1.0	-0.9	-0.3	-0.9	-1.8	-1.4	0.2	0.3	-1.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.0	-0.2	-0.5	0.8	0.8	1.0	-0.7	-0.9	-2.0	-0.5	-1.5	0.7	1.1	-1.6
High blood pressure (mother)	0.9	1.2	5.1	-0.2	0.5	1.5	-0.5	0.0	0.5	-1.6	-2.3	-0.9	-1.5	0.1	-0.4	-1.4
Trunk fat-free mass	0.9	5.4	17.9	-1.9	-4.2	-1.6	-0.6	-3.7	-3.5	-2.4	-2.1	-2.1	-1.1	1.4	0.9	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	5.3	-0.0	-0.3	0.7	0.5	-1.5	0.2	-0.9	-2.3	-0.5	-2.0	0.6	-0.2	-0.2
Prospective memory result	0.9	1.1	5.6	0.2	-0.7	0.3	2.2	2.4	-0.2	0.2	-1.6	0.1	-0.1	-0.5	0.2	-0.6
Illnesses of mother	0.9	1.2	7.1	-0.3	-0.9	-1.2	-0.6	-0.4	-0.8	1.3	2.7	0.1	1.0	0.1	0.4	1.3
Trunk predicted mass	0.9	5.4	18.6	-1.9	-4.3	-1.6	-0.6	-3.7	-3.5	-2.4	-2.1	-2.1	-1.1	1.4	0.8	-0.6
Worry too long after embarrassment	0.9	1.5	8.7	0.7	-0.0	0.7	0.1	-0.7	-1.0	-1.7	-2.9	0.4	-1.3	0.5	1.3	-1.4
Medication: Allopurinol	0.9	1.2	7.8	1.2	2.8	1.7	0.8	0.1	-0.0	0.0	-0.6	1.1	-0.5	-0.3	-0.4	1.2
Family relationship satisfaction	0.9	1.1	3.8	-0.9	0.0	-0.6	0.1	-0.2	1.4	1.0	1.4	-0.4	0.3	-1.1	-1.6	1.9
Illnesses of father: None of the above (group 1)	0.9	1.1	4.9	0.9	0.5	0.7	-1.1	-0.3	-0.5	1.0	-0.3	1.3	-0.8	2.2	1.2	1.3
Medication: Blood pressure	0.9	1.6	8.6	-0.1	0.9	1.3	0.5	1.8	1.2	-0.7	-2.9	-0.9	-1.6	-1.2	0.1	-0.6
Illnesses of father: High blood pressure	0.9	1.2	4.4	1.2	-0.2	1.6	0.4	0.6	-0.1	-2.1	-2.0	0.1	-0.3	0.6	0.2	-1.3
Alcohol drinker status: Never	0.9	1.0	4.7	-0.7	-0.3	-0.4	2.2	1.5	1.4	-0.1	-0.3	-0.7	-0.3	-0.6	-0.4	-1.6
Ovarian Cancer	0.8	1.0	4.3	1.2	2.1	1.1	-0.9	-1.3	-0.1	0.5	0.2	1.2	-0.5	1.1	0.8	-0.3
Body Mass Index (BMI) (2010)	0.8	1.1	4.8	-1.6	-2.2	-1.1	-0.9	-0.4	-0.4	-0.7	-0.6	-1.5	-0.2	-0.5	-0.9	-0.6
Coronary Artery Disease (CAD)	0.8	1.0	3.0	-0.5	0.2	-0.5	1.7	1.0	0.8	1.7	0.8	0.1	0.8	-1.5	-1.1	0.5
Cardiovascular Disease	0.8	2.7	8.0	-0.8	-0.4	-1.0	1.6	2.4	2.2	0.7	-2.2	-1.7	-0.3	-2.8	-0.8	-1.9
Chronotype (morning person)	0.8	1.8	7.2	-0.6	1.8	1.3	-0.1	-1.3	-0.1	-0.9	-1.3	-0.5	-2.7	-1.1	-1.9	0.9
Diabetes (father)	0.8	1.0	3.7	0.4	0.9	1.3	-0.5	1.9	0.2	-0.4	-1.6	-0.1	-1.7	0.1	0.8	-0.6
Townsend deprivation index at recruitment	0.8	1.1	4.5	-1.2	-2.1	-1.6	-1.3	0.7	0.5	0.3	0.4	-0.7	0.9	-0.6	-0.4	-1.3
Number of incorrect matches in round	0.8	1.3	4.8	1.6	1.2	0.5	0.0	0.9	-1.1	0.8	0.7	2.2	0.9	1.0	0.8	1.6
Medication: Simvastatin	0.8	1.2	5.0	-0.7	0.6	-0.7	1.7	-0.0	1.7	0.7	-0.7	-1.0	0.6	-1.1	0.1	-2.2
Length of working week for main job	0.8	0.9	2.8	0.3	-1.0	0.2	-1.6	-0.4	-1.7	-1.2	0.0	0.6	-0.6	0.9	0.2	1.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.9	-1.7	-1.2	-0.9	-0.7	0.4	0.8	0.3	-1.0	-1.3	-0.3	-0.7	-1.7	-0.1
Number of children fathered	0.8	0.9	2.7	-1.6	-1.0	-1.0	0.3	-0.4	-0.3	0.3	0.4	-1.4	1.5	-1.0	-1.0	0.4
Health satisfaction	0.8	1.1	3.3	0.4	-0.2	-0.8	1.6	1.8	1.5	0.4	-0.6	0.4	0.9	-0.9	-0.9	-1.2
Shortness of breath walking on level ground	0.8	0.9	2.4	-1.3	-0.7	-1.0	0.3	1.0	0.4	-0.3	0.1	-1.6	-0.0	-1.4	-1.5	0.6
Had major operations	0.8	0.9	3.2	-1.2	-1.1	-0.6	-0.4	-1.2	0.4	-0.3	1.0	-1.2	1.8	-0.2	-1.1	-0.6
Medication: Gliclazide	0.8	0.9	3.7	-0.8	0.1	-0.1	0.1	0.8	1.3	1.2	-0.3	-1.9	-1.0	-1.0	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.4	2.3	1.4	0.9	1.4	-0.7	-0.1	0.5	0.2	2.3	1.7	1.5	1.2	0.2
Eye problems/disorders: Glaucoma	0.8	0.9	2.6	-0.9	-0.3	-0.1	-1.0	-0.9	-0.9	-1.6	-1.3	-1.6	-1.2	0.0	0.1	-0.6
Medication: Lisinopril	0.8	1.0	4.1	0.4	0.4	1.1	-0.3	0.4	0.0	-1.4	-1.9	-0.7	-2.0	0.2	-0.1	1.3
Ever smoked	0.8	1.4	7.2	1.0	-0.4	0.4	2.7	1.1	2.1	0.6	0.0	0.9	0.1	0.4	-1.4	-0.3
Number of operations (self-reported)	0.8	1.2	3.5	-1.7	-1.1	-0.8	-1.5	0.5	-0.6	-1.2	-0.4	-1.9	0.8	-0.3	0.1	-1.5
Bipolar Disorder or Schizophrenia	0.7	1.6	8.4	0.5	0.1	0.1	2.1	1.4	1.0	2.9	0.2	0.3	0.7	0.7	1.5	-1.2
Irritable Bowel Disease (IBD)	0.7	1.6	4.0	-2.0	0.4	-1.9	-0.3	-0.4	-0.5	1.6	1.7	-1.1	0.9	-1.8	-1.3	0.2
Crohns Disease (2012)	0.7	1.1	3.2	0.6	1.2	0.4	0.1	-1.8	-0.5	1.3	0.6	1.3	-0.2	1.3	1.6	0.6
Heel T-Score	0.7	5.7	13.8	2.1	2.4	3.7	1.0	0.6	-0.9	-1.3	-3.0	-0.2	-3.6	3.0	3.4	-1.7
Hearing difficulty/problems: Yes	0.7	1.1	3.3	-1.2	-1.4	-0.9	-1.2	0.0	-0.6	-1.8	-0.4	-1.3	-0.2	-1.1	-1.4	-0.0
Vitamin and mineral supplements	0.7	0.9	4.2	-0.9	-2.1	-1.6	-1.0	-0.2	-1.3	0.2	0.2	-0.7	-0.5	-0.7	0.5	-0.3
Average weekly fortified wine intake	0.7	0.8	3.8	0.1	1.3	1.0	1.9	0.2	1.0	0.2	-1.0	-0.8	-0.8	0.6	0.4	0.4
Past tobacco smoking	0.7	1.2	5.3	-1.1	1.0	-0.2	-2.3	-0.6	-1.2	-1.1	0.1	-1.2	-0.7	-1.4	-0.4	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	7.4	-1.2	-0.5	-0.1	0.2	1.1	-0.1	-0.3	-0.9	-1.5	-0.8	-0.1	-0.1	-2.7
Gout (self-reported)	0.7	1.0	4.0	1.0	2.0	1.2	-0.2	-1.2	-0.6	0.7	-0.9	1.0	-0.8	0.5	0.6	0.6
Heart disease (mother)	0.7	0.8	3.8	0.4	1.6	0.9	-0.2	0.1	-0.3	-1.2	-1.9	0.1	-1.4	0.3	0.5	-0.4
Eye problems/disorders: Cataract	0.7	0.8	2.3	0.3	-0.9	0.4	0.1	1.0	-0.7	-0.1	-1.5	-0.4	-1.1	1.4	1.3	-0.6
Back pain experienced in last month	0.7	1.0	4.0	-0.4	-2.0	-1.2	0.1	0.4	0.2	-1.6	-0.9	0.3	0.8	-0.8	-0.8	-1.3
Cholesterol lowering medication	0.7	1.1	3.6	-1.4	-0.1	-0.9	0.8	1.3	0.5	0.2	-1.5	-1.9	-0.5	-1.3	0.4	-0.6
Depressed Affect (Nagel 2018)	0.6	1.2	7.3	-1.1	-1.1	-1.1	0.2	2.7	0.1	-0.9	-1.5	-0.8	-0.5	-0.6	-0.3	-0.9
HDL Cholesterol	0.6	1.1	3.9	1.1	1.1	2.0	0.0	-0.1	-1.5	0.1	-0.1	0.9	-1.2	1.1	1.0	0.9
Lupus	0.6	0.8	2.3	-1.0	-1.5	-1.3	-0.2	-0.9	-0.6	-0.8	0.5	-0.8	0.9	-0.1	1.1	-1.1
Neuroticism	0.6	1.6	8.9	0.9	1.2	1.2	1.4	1.3	0.4	-0.6	-3.0	0.9	-1.4	0.4	1.0	0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.5	0.7	0.4	1.0	0.2	0.5	-0.1	0.1	-1.6	0.6	-1.1	0.8	1.5	0.2
Hearing difficulty/problems with background noise	0.6	1.0	2.4	-1.4	-0.6	-1.2	-1.6	-0.4	-1.5	-1.1	-0.1	-1.4	-0.1	-1.0	-0.1	-0.4
Hair/balding pattern: Pattern 2	0.6	0.8	3.7	0.3	-0.7	-0.4	0.2	0.8	0.6	1.2	1.2	0.8	1.9	0.4	0.6	-0.9
Illnesses of siblings	0.6	0.8	2.2	0.9	0.7	1.0	-0.6	-0.4	-0.9	-0.3	-0.2	0.7	-1.3	1.3	0.9	1.5
Medication: Cholesterol lowering	0.6	1.0	2.8	-0.7	-1.2	-1.7	1.0	0.4	0.5	0.2	-0.1	-0.5	1.2	-1.4	-0.5	-1.7
Standing height	0.6	6.2	19.3	2.9	0.3	2.7	-2.2	-3.1	-1.9	-3.4	-1.0	2.3	-1.4	4.4	1.4	2.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	-1.1	-1.3	-1.1	-0.6	0.4	-0.4	1.1	-0.2	-1.4	-0.2	-0.6	0.4	-0.6
Exposure to tobacco smoke outside home	0.6	0.7	3.3	-0.0	0.4	0.9	0.4	0.9	0.7	-0.0	-0.7	-0.5	-1.8	-0.4	-1.1	1.3
Emphysema/chronic bronchitis	0.6	0.7	1.7	-0.3	-0.6	-0.8	0.5	1.2	0.7	1.1	0.8	0.1	1.3	-1.2	-0.4	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	-1.0	1.1	0.1	-0.8	0.7	0.1	-0.6	-0.9	-0.8	-1.1	-1.4	-0.7	0.2
Diastolic blood pressure, automated reading	0.6	1.9	7.4	-2.2	-0.5	-0.9	0.8	0.7	1.1	-0.2	0.5	-1.9	-0.7	-2.7	-2.0	-0.7
Unable to work because of sickness or disability	0.6	0.7	2.8	-0.7	-1.1	-0.7	0.6	0.7	0.3	0.9	1.7	-0.4	1.1	0.1	0.9	-0.6
Basal cell carcinoma (self-reported)	0.6	0.7	3.0	0.4	0.9	1.1	-0.4	-0.7	-1.7	-0.8	-0.2	0.1	-0.8	1.1	-0.0	0.7
Reaction Time	0.5	1.0	3.3	-1.2	0.3	-0.0	-0.1	1.0	0.5	-1.3	-1.0	-1.8	-1.4	-1.2	-1.2	-0.2
Breast Cancer	0.5	1.3	4.1	-1.3	-2.0	-1.0	-0.2	-0.5	-0.3	-1.1	-1.6	-1.5	-0.8	-1.0	0.0	-1.3
HbA1C	0.5	0.6	3.4	-0.3	0.0	-0.7	0.2	-0.8	0.8	-0.5	0.0	-0.1	0.3	-1.0	-1.8	0.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.8	-0.6	-1.7	-0.7	0.3	0.8	0.6	0.3	-0.7	-0.9	-0.5	-0.2	-0.9	0.5
Blood Eosinophil Count	0.5	3.8	10.0	-2.5	-2.2	-3.2	-2.4	-0.5	-2.0	-0.9	2.5	-2.0	0.9	-2.2	-1.5	-0.1
Height	0.5	9.3	33.9	3.3	-0.4	3.0	-2.5	-3.8	-2.7	-2.8	-2.4	3.1	-1.8	5.8	3.3	1.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.6	-0.3	0.3	-0.1	-0.2	0.7	-0.1	-0.5	-1.6	-0.6	-1.2	-0.3	-0.8	1.0
Had menopause	0.5	0.7	4.5	-0.6	0.6	-0.7	-0.3	-0.3	-0.8	-0.2	2.1	-0.5	1.0	-0.7	-0.1	0.4
Neuroticism score	0.5	1.0	5.5	0.5	1.1	0.9	1.1	1.0	0.1	-0.9	-2.4	0.2	-1.3	0.0	0.5	-0.0
Depression (self-reported)	0.5	0.6	3.7	-0.2	0.1	0.6	0.1	-0.5	0.6	1.9	-0.6	0.2	0.2	0.8	0.8	-0.9
Peak expiratory flow (PEF)	0.5	1.2	5.9	1.0	-0.4	-0.0	1.0	-1.4	0.0	0.1	1.1	1.6	2.4	1.0	0.5	-0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.9	0.3	0.3	0.8	-1.0	-1.0	-1.0	-0.1	1.0	0.8	-0.3	1.6	0.5	1.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	3.4	0.2	1.8	0.1	-0.1	-0.4	-1.0	0.1	1.4	0.6	1.0	-0.8	-0.3	0.0
Supplements: Vitamin C	0.5	0.5	1.6	0.2	0.8	0.8	1.3	0.1	0.9	-0.5	0.2	0.5	1.1	0.5	-0.1	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	-1.1	-0.0	-0.4	1.4	1.0	0.3	0.2	0.6	-0.8	0.7	-0.6	0.3	-0.9
Illnesses of father: Heart disease	0.5	0.7	2.1	-0.1	-0.1	-0.1	1.4	-1.0	0.4	-1.4	0.8	0.3	1.0	-1.3	-0.6	-0.7
Financial situation satisfaction	0.5	0.7	1.7	-0.8	-0.8	-1.1	0.8	1.0	1.1	0.5	-0.5	-1.3	0.1	-0.9	-0.3	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.5	2.6	-0.3	-0.8	0.3	1.2	0.0	1.6	0.3	-0.6	-0.3	-0.2	-0.3	-1.1	-0.6
Average weekly beer plus cider intake	0.5	0.7	4.5	-0.6	-2.1	-0.7	0.2	-0.4	0.9	0.9	0.7	-0.6	0.5	0.2	-0.6	-0.4
Schizophrenia (2014)	0.4	0.8	4.8	0.2	0.6	0.1	1.1	2.2	0.7	1.5	-0.7	-0.1	-0.1	-0.4	0.3	-0.8
Sensitivity / hurt feelings	0.4	0.7	3.0	1.1	1.7	1.1	0.5	0.5	-0.3	-0.6	-1.2	0.5	-0.8	0.0	0.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.3	-0.4	-0.5	-0.3	0.5	0.6	-0.7	-0.8	-1.2	-0.0	-0.4	-0.1	1.1	-0.6
High blood pressure	0.4	1.1	4.9	0.3	1.7	0.9	0.6	1.6	0.5	0.1	-2.2	-0.7	-0.8	-1.1	0.4	-0.2
Birth weight of first child	0.4	0.8	2.0	0.9	0.3	1.3	-0.7	-0.1	-1.4	-0.5	0.6	1.4	-0.4	1.0	0.5	1.2
Glaucoma (self-reported)	0.4	0.5	2.3	-0.3	-0.6	-0.4	-1.3	-0.3	-1.1	-1.5	-0.1	-0.5	-0.1	0.1	0.2	0.3
Medication: Amlodipine	0.4	0.6	2.3	0.5	0.5	0.6	0.6	0.2	1.5	0.4	-1.0	-0.1	-1.5	-0.7	-0.2	-0.1
Comparative body size at age 10	0.4	1.1	8.0	0.3	0.1	0.9	-0.1	-2.8	-0.8	-0.4	-0.7	0.5	-1.0	1.4	1.0	0.5
Breast cancer (self-reported)	0.4	0.4	3.4	-0.5	1.9	0.6	0.1	-0.1	0.5	0.4	0.0	-0.7	-0.3	0.5	0.6	0.1
High cholesterol (Self-reported)	0.4	0.6	1.9	-0.2	-1.0	-0.8	1.4	1.1	0.9	0.3	-0.3	-0.2	0.6	-0.8	0.6	-1.0
Medication: Bendroflumethiazide	0.4	0.7	2.4	0.7	0.8	0.6	-0.0	1.3	0.7	0.4	-1.6	0.4	-1.1	-0.5	0.8	-0.2
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.4	0.3	-0.8	0.1	-0.5	-2.1	-0.8	-0.3	1.8	1.3	0.1	1.8	-0.0	1.0
Alcohol drinker status: Previous	0.4	0.5	2.8	0.4	-1.7	-0.1	-0.8	-0.1	-0.3	-0.5	-1.2	0.4	-0.0	0.1	-0.6	0.6
Depression (Nagel 2018)	0.3	0.4	1.4	-0.9	-1.2	-0.0	0.2	0.8	-0.0	0.4	-0.6	-0.3	-0.1	0.3	0.4	-1.1
Schizophrenia (2018)	0.3	0.6	2.3	-0.3	0.2	-0.1	0.6	1.5	1.0	1.3	-0.5	-0.7	-0.1	-0.4	-0.3	-1.5
Crohns Disease (2017)	0.3	0.7	3.6	0.0	1.4	0.3	0.0	-1.9	-0.6	0.8	-0.1	0.6	-1.0	0.6	0.4	0.7
Triglycerides	0.3	0.4	1.7	0.0	0.0	-0.3	0.3	0.6	1.3	-0.1	-1.3	-0.4	-0.9	-0.1	0.3	-0.8
Blood Platelet Count	0.3	3.2	10.7	0.8	0.2	2.6	0.0	0.9	0.2	0.1	-1.9	0.7	-3.3	2.7	3.3	-0.2
Blood White Count	0.3	2.2	8.7	-1.9	-2.0	-0.6	1.2	0.6	0.5	2.0	0.5	-1.9	0.4	0.0	1.1	-3.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	-0.8	-0.8	-0.6	-0.3	-0.1	0.8	0.6	0.4	0.2	1.0	0.3	0.4	-0.8
Supplements: Zinc	0.3	0.4	1.4	-1.2	0.2	0.5	-0.5	-0.8	0.1	0.3	0.6	-1.1	-0.1	0.4	0.3	0.2
Pack years adult smoking proportion	0.3	0.5	1.0	-0.6	-0.1	-0.5	-1.0	0.8	-0.9	-0.2	-0.4	-0.6	-0.7	-0.8	-0.7	0.8
Happiness	0.3	0.3	1.1	0.3	0.4	0.3	-0.8	-0.8	-0.3	-0.4	0.7	0.8	0.0	0.6	0.4	1.0
Pulse wave reflection index	0.3	0.4	1.0	-0.1	0.0	0.0	-0.9	0.7	-1.0	-0.6	-1.0	0.4	-0.7	-0.2	0.3	0.8
Blood clot in the leg (DVT)	0.3	0.4	1.3	-0.2	-0.4	-0.3	0.2	-0.7	-0.2	-1.1	-0.8	-0.4	-0.5	-0.8	-0.8	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.8	-0.5	0.3	0.1	0.5	0.4	0.8	-0.0	0.7	-0.1	0.9	-0.8	-0.9	-0.6
Medication: Ibuprofen	0.3	0.4	2.4	0.0	0.1	0.8	-0.0	0.6	0.6	0.5	-0.8	-0.2	-0.5	1.6	0.4	0.1
Mean time to correctly identify matches	0.3	0.6	1.9	-0.7	0.9	0.6	-0.5	0.7	-0.5	-1.1	-0.8	-1.4	-1.2	-0.3	-0.3	0.3
Pulse rate, automated reading	0.3	0.9	3.1	-0.9	-1.6	-1.3	0.5	1.8	0.7	-0.1	-0.3	-0.8	-0.9	-0.8	-0.5	-0.4
Hypertension (Self-reported)	0.3	0.9	4.1	0.3	1.6	0.8	0.4	1.3	0.3	0.1	-2.0	-0.8	-0.8	-1.1	0.6	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.7	0.1	-0.5	0.4	-1.3	0.5	-0.7	-0.7	-0.6	0.2	0.1	0.3	-0.1	0.9
Mood swings	0.3	0.5	2.9	-0.4	-0.5	-0.5	0.7	1.3	0.1	-0.6	-1.7	-0.2	-0.1	-0.2	0.5	-0.8
Miserableness	0.3	0.5	1.9	-0.0	-0.3	-1.0	-0.3	0.8	-1.0	-0.8	-0.7	0.2	0.2	0.1	1.4	-0.7
Fractured/broken bones in last 5 years	0.3	0.3	1.3	-0.4	0.6	0.3	0.4	-0.3	1.1	0.6	-1.1	-0.0	-0.8	0.1	-0.4	0.0
Myopia	0.3	0.5	2.1	0.8	0.7	0.8	0.3	-0.0	0.9	0.2	-0.0	0.9	-0.2	0.3	-0.8	1.5
Pack years of smoking	0.3	0.5	1.8	-0.2	0.2	-0.3	-1.1	0.7	-1.3	-0.4	-0.7	-0.4	-0.8	-0.6	-0.2	0.9
Relative age voice broke	0.2	0.4	1.4	0.2	0.5	0.0	0.1	0.0	-0.9	0.7	0.4	0.4	1.2	0.7	0.7	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.3	0.1	0.5	0.4	-1.1	0.1	-0.7	-0.0	-1.1	0.1	-0.5	0.8	0.8	-0.4
Pulse rate	0.2	0.4	1.0	-0.6	-1.0	-0.4	0.3	0.9	0.3	-1.0	-0.1	-0.9	-0.4	-0.4	-0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.1	-0.2	0.2	0.4	0.4	0.3	0.9	0.4	-0.5	-0.2	-0.3	1.1	-0.2	0.2
Medication: Lansoprazole	0.2	0.3	1.6	-0.1	0.3	-0.2	1.3	0.4	-0.2	-0.8	0.3	-0.6	-0.1	-0.1	0.3	-0.3
Medication: Blood pressure	0.2	0.4	1.5	-0.3	-0.0	-0.7	-0.3	0.6	0.4	0.2	-0.8	-0.6	0.0	-1.2	-0.2	-0.9
Migraine (self-reported)	0.2	0.3	0.9	-0.7	-0.3	-0.2	0.9	-0.2	0.1	-0.9	-0.2	-0.5	0.6	-0.6	-0.4	-0.7
Comparative height size at age 10	0.2	0.9	3.6	0.1	0.6	0.7	0.3	-1.9	0.9	-0.8	-0.4	-0.1	-0.4	0.1	-1.3	1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	2.2	-0.1	0.7	0.6	-0.5	-0.6	1.0	0.4	-0.5	0.0	-0.3	-0.4	-1.5	0.4
Osteoporosis (self-reported)	0.2	0.2	0.6	-0.6	-0.3	-0.7	0.6	-0.0	-0.0	-0.7	0.7	-0.4	0.2	-0.4	-0.2	-0.7
Wears glasses or contact lenses	0.2	0.2	0.6	-0.3	-0.8	-0.5	-0.2	-0.4	0.1	-0.6	-0.1	-0.7	0.4	-0.1	0.5	-0.7
Ever taken oral contraceptive pill	0.2	0.3	1.1	0.5	-0.4	0.2	-0.7	0.4	-0.3	0.2	-0.1	0.4	0.1	0.7	1.0	-0.7
Irritability	0.2	0.4	2.1	0.1	0.4	-0.0	-0.4	0.8	0.2	-0.2	-1.4	-0.3	-0.0	0.9	1.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	-0.2	-0.4	-0.1	0.3	-0.7	0.2	-0.9	-0.7	-0.4	-0.7	-0.7	-0.8	0.6
Alzheimer’s Disease (including proxy)	0.1	0.2	1.6	-0.1	-0.3	0.5	-0.1	-1.3	-0.4	0.2	-0.4	0.4	-0.0	0.2	-0.3	-0.3
LDL Cholesterol	0.1	0.2	0.6	0.1	0.0	-0.1	-0.2	-0.2	-0.2	-0.7	0.1	0.2	-0.8	-0.4	-0.8	-0.0
Hair Pigment	0.1	1.4	5.2	-1.0	-1.6	-1.0	1.7	1.0	0.5	0.8	-0.6	-0.7	0.7	-1.2	-1.2	-2.3
Tanning	0.1	0.7	4.8	-0.4	-2.2	-0.8	-0.3	0.9	-0.2	-0.2	0.9	0.1	1.1	-0.1	0.3	-0.6
Number of live births	0.1	0.2	0.5	-0.7	-0.5	-0.4	-0.5	0.5	-0.3	-0.4	-0.3	-0.5	-0.6	-0.6	0.0	-0.1
Birth weight	0.1	0.3	1.4	0.2	-1.2	0.3	0.3	0.4	0.6	0.3	-0.1	-0.0	-0.2	0.6	0.7	0.0
High blood pressure (siblings)	0.1	0.1	0.2	-0.3	0.3	0.5	0.3	-0.1	0.5	-0.3	-0.4	-0.5	0.1	-0.5	-0.4	-0.4

Hub : Genes

AFF3

Models

Trait associations