Best TWAS P=7.21e-11 · Best GWAS P=8.41e-11 conditioned to 0.0216
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BMP8A | 0.05 | 0.03 | lasso | 3 | 0.02 | 8.8e-04 | 5.1 | 5.3 | 1.0e-07 | 0.71 | 0.06 | 0.89 | FALSE |
| 2 | GTEx | Adrenal Gland | PABPC4 | 0.20 | 0.09 | lasso | 8 | 0.06 | 3.0e-03 | 5.1 | -6.5 | 7.2e-11 | -0.77 | 0.04 | 0.85 | TRUE |
| 3 | GTEx | Adrenal Gland | RP11-69E11.4 | 0.11 | 0.05 | lasso | 3 | 0.00 | 2.4e-01 | 4.6 | 5.4 | 7.0e-08 | 0.52 | 0.06 | 0.48 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | PABPC4 | 0.10 | 0.00 | enet | 9 | 0.01 | 1.5e-01 | 6.0 | -6.3 | 2.4e-10 | -0.83 | 0.04 | 0.43 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | PABPC4 | 0.07 | 0.09 | lasso | 1 | 0.06 | 2.7e-05 | 5.1 | -5.1 | 3.1e-07 | -0.68 | 0.12 | 0.85 | FALSE |
| 6 | GTEx | Nerve Tibial | RP11-69E11.8 | 0.05 | 0.00 | lasso | 3 | 0.01 | 6.9e-02 | 5.1 | -5.3 | 8.9e-08 | -0.75 | 0.04 | 0.85 | FALSE |
| 7 | NTR | Blood | PABPC4 | 0.01 | 0.00 | blup | 383 | 0.00 | 2.8e-02 | 5.1 | -5.7 | 1.2e-08 | -0.68 | 0.03 | 0.66 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BMP8A | 0.04 | 0.03 | blup | 48 | 0.04 | 3.5e-05 | 4.0 | 5.7 | 9.9e-09 | 0.68 | 0.02 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BMP8A | 0.05 | 0.01 | blup | 48 | 0.04 | 6.8e-05 | 5.7 | 6.4 | 1.6e-10 | 0.68 | 0.00 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | PABPC4 | 0.09 | 0.07 | enet | 5 | 0.08 | 4.1e-08 | 5.1 | -6.5 | 1.1e-10 | -0.62 | 0.00 | 0.99 | FALSE |