Best TWAS P=2.13e-10 · Best GWAS P=5.44e-09 conditioned to 0.931
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TMEM54 | 0.05 | 0.00 | blup | 281 | 0.02 | 4.5e-03 | 1.6 | -6.3 | 2.1e-10 | 0.41 | 0.10 | 0.30 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | PHC2 | 0.58 | 0.34 | lasso | 7 | 0.28 | 7.3e-10 | -5.2 | 5.2 | 1.6e-07 | -0.06 | 0.08 | 0.92 | FALSE |
| 3 | GTEx | Muscle Skeletal | FNDC5 | 0.15 | 0.16 | enet | 5 | 0.16 | 1.9e-15 | -5.4 | -5.5 | 4.9e-08 | 0.96 | 0.04 | 0.96 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | S100PBP | 0.03 | 0.02 | blup | 46 | 0.02 | 6.6e-06 | -5.8 | 5.5 | 3.2e-08 | -0.91 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | S100PBP | 0.06 | 0.03 | blup | 48 | 0.06 | 6.8e-04 | -5.6 | 6.2 | 5.0e-10 | -0.91 | 0.01 | 0.81 | TRUE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | S100PBP | 0.21 | 0.15 | lasso | 5 | 0.15 | 2.9e-05 | -5.4 | 5.4 | 5.6e-08 | -0.96 | 0.01 | 0.91 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | S100PBP | 0.04 | 0.04 | lasso | 4 | 0.04 | 2.3e-05 | -5.8 | 5.8 | 7.3e-09 | -1.00 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FNDC5 | 0.03 | 0.04 | enet | 6 | 0.03 | 2.9e-04 | -5.6 | -5.2 | 1.9e-07 | 0.80 | 0.01 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | S100PBP | 0.06 | 0.06 | blup | 47 | 0.05 | 5.2e-06 | -5.8 | 5.8 | 5.2e-09 | -0.92 | 0.01 | 0.99 | FALSE |