Best TWAS P=1.54e-15 · Best GWAS P=1.38e-11 conditioned to 0.129
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | U91328.19 | 0.40 | 0.46 | lasso | 8 | 0.46 | 4.2e-41 | -6.4 | 6.3 | 3.8e-10 | -0.87 | 0.04 | 0.96 | FALSE |
2 | GTEx | Adipose Visceral Omentum | U91328.19 | 0.21 | 0.25 | lasso | 8 | 0.27 | 3.7e-14 | -6.4 | 6.6 | 3.3e-11 | -0.93 | 0.02 | 0.98 | FALSE |
3 | GTEx | Adrenal Gland | U91328.19 | 0.28 | 0.12 | lasso | 10 | 0.14 | 1.3e-05 | -5.7 | 6.9 | 4.0e-12 | -0.86 | 0.07 | 0.93 | FALSE |
4 | GTEx | Artery Aorta | U91328.19 | 0.32 | 0.24 | lasso | 7 | 0.25 | 8.3e-14 | -6.6 | 6.9 | 4.3e-12 | -0.94 | 0.01 | 0.99 | FALSE |
5 | GTEx | Artery Coronary | U91328.19 | 0.32 | 0.16 | enet | 44 | 0.23 | 3.7e-08 | -6.4 | 5.8 | 5.2e-09 | -0.73 | 0.02 | 0.98 | FALSE |
6 | GTEx | Artery Tibial | U91328.19 | 0.26 | 0.32 | lasso | 5 | 0.31 | 1.6e-24 | -6.4 | 6.5 | 8.6e-11 | -0.88 | 0.04 | 0.96 | FALSE |
7 | GTEx | Brain Caudate basal ganglia | U91328.19 | 0.23 | 0.16 | lasso | 10 | 0.16 | 3.1e-05 | -5.7 | 6.5 | 1.2e-10 | -0.75 | 0.20 | 0.73 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | U91328.19 | 0.47 | 0.33 | enet | 44 | 0.26 | 2.8e-07 | -5.6 | 6.5 | 8.9e-11 | -0.51 | 0.52 | 0.46 | FALSE |
9 | GTEx | Brain Cerebellum | U91328.19 | 0.13 | 0.15 | lasso | 2 | 0.09 | 1.1e-03 | -5.5 | 5.4 | 7.4e-08 | -0.52 | 0.24 | 0.35 | FALSE |
10 | GTEx | Brain Cortex | U91328.19 | 0.36 | 0.14 | lasso | 10 | 0.15 | 7.1e-05 | -6.6 | 6.9 | 5.0e-12 | -0.77 | 0.06 | 0.91 | FALSE |
11 | GTEx | Brain Frontal Cortex BA9 | U91328.19 | 0.17 | 0.16 | lasso | 4 | 0.18 | 1.8e-05 | -6.6 | 6.7 | 2.0e-11 | -0.83 | 0.03 | 0.93 | FALSE |
12 | GTEx | Breast Mammary Tissue | U91328.19 | 0.38 | 0.39 | lasso | 5 | 0.38 | 2.2e-20 | -6.4 | 6.5 | 7.5e-11 | -0.87 | 0.04 | 0.96 | FALSE |
13 | GTEx | Breast Mammary Tissue (Male) | U91328.19 | 0.35 | 0.15 | enet | 25 | 0.15 | 2.9e-04 | -6.4 | 5.3 | 9.9e-08 | -0.78 | 0.03 | 0.93 | FALSE |
14 | GTEx | Breast Mammary Tissue (Female) | U91328.19 | 0.39 | 0.27 | lasso | 6 | 0.23 | 1.4e-07 | -6.4 | 6.6 | 3.2e-11 | -0.85 | 0.03 | 0.97 | FALSE |
15 | GTEx | Cells Transformed fibroblasts | U91328.19 | 0.58 | 0.62 | lasso | 8 | 0.60 | 6.2e-56 | -6.4 | 6.3 | 2.7e-10 | -0.87 | 0.04 | 0.96 | FALSE |
16 | GTEx | Esophagus Gastroesophageal Junction | U91328.19 | 0.28 | 0.07 | lasso | 7 | 0.21 | 4.3e-08 | -6.6 | 5.1 | 2.9e-07 | -0.76 | 0.03 | 0.96 | FALSE |
17 | GTEx | Esophagus Mucosa | U91328.19 | 0.45 | 0.42 | lasso | 7 | 0.44 | 6.3e-32 | -6.4 | 6.7 | 2.2e-11 | -0.90 | 0.04 | 0.96 | FALSE |
18 | GTEx | Esophagus Muscularis | TRIM38 | 0.06 | 0.04 | lasso | 4 | 0.02 | 1.7e-02 | -6.6 | 5.3 | 1.1e-07 | -0.85 | 0.08 | 0.85 | FALSE |
19 | GTEx | Esophagus Muscularis | U91328.19 | 0.36 | 0.30 | lasso | 10 | 0.30 | 1.7e-18 | -6.6 | 6.3 | 3.1e-10 | -0.96 | 0.02 | 0.98 | FALSE |
20 | GTEx | Heart Atrial Appendage | U91328.19 | 0.25 | 0.17 | enet | 6 | 0.13 | 2.0e-06 | -6.4 | 6.7 | 2.9e-11 | -0.92 | 0.02 | 0.98 | FALSE |
21 | GTEx | Heart Left Ventricle | U91328.19 | 0.20 | 0.18 | lasso | 5 | 0.15 | 2.4e-08 | -6.4 | 6.3 | 2.8e-10 | -0.86 | 0.04 | 0.96 | FALSE |
22 | GTEx | Lung | U91328.19 | 0.20 | 0.22 | enet | 15 | 0.24 | 2.9e-18 | -6.8 | 7.0 | 1.8e-12 | -0.95 | 0.01 | 0.99 | FALSE |
23 | GTEx | Muscle Skeletal | U91328.19 | 0.28 | 0.26 | enet | 15 | 0.32 | 1.3e-31 | -6.4 | 6.2 | 4.0e-10 | -0.80 | 0.04 | 0.96 | FALSE |
24 | GTEx | Nerve Tibial | U91328.19 | 0.46 | 0.38 | lasso | 10 | 0.36 | 1.4e-26 | -6.4 | 6.5 | 9.5e-11 | -0.87 | 0.04 | 0.96 | FALSE |
25 | GTEx | Ovary | U91328.19 | 0.37 | 0.17 | enet | 18 | 0.34 | 4.7e-09 | -6.6 | 8.0 | 1.5e-15 | -0.84 | 0.02 | 0.98 | TRUE |
26 | GTEx | Prostate | U91328.19 | 0.30 | 0.39 | lasso | 2 | 0.37 | 3.0e-10 | -6.4 | 6.4 | 1.5e-10 | -0.87 | 0.03 | 0.97 | FALSE |
27 | GTEx | Skin Not Sun Exposed Suprapubic | U91328.19 | 0.39 | 0.37 | lasso | 11 | 0.34 | 2.4e-19 | -6.4 | 6.7 | 2.4e-11 | -0.91 | 0.03 | 0.97 | FALSE |
28 | GTEx | Skin Sun Exposed Lower leg | U91328.19 | 0.29 | 0.34 | lasso | 6 | 0.34 | 5.6e-29 | -6.4 | 6.7 | 2.8e-11 | -0.86 | 0.04 | 0.96 | FALSE |
29 | GTEx | Stomach | U91328.19 | 0.17 | 0.05 | lasso | 5 | 0.05 | 1.7e-03 | -6.4 | 5.5 | 3.5e-08 | -0.79 | 0.04 | 0.93 | FALSE |
30 | GTEx | Thyroid | U91328.19 | 0.21 | 0.17 | lasso | 5 | 0.17 | 6.4e-13 | -6.4 | 6.0 | 2.1e-09 | -0.85 | 0.04 | 0.96 | FALSE |
31 | GTEx | Uterus | U91328.19 | 0.38 | 0.05 | enet | 21 | 0.04 | 6.2e-02 | -6.8 | 7.5 | 8.6e-14 | -0.85 | 0.02 | 0.87 | FALSE |
32 | GTEx | Vagina | U91328.19 | 0.45 | 0.27 | lasso | 4 | 0.26 | 9.4e-07 | -6.4 | 6.2 | 4.3e-10 | -0.85 | 0.03 | 0.96 | FALSE |
33 | METSIM | Adipose | U91328.19 | 0.19 | 0.24 | lasso | 23 | 0.25 | 1.7e-36 | -6.4 | 6.9 | 5.6e-12 | -0.85 | 0.04 | 0.96 | FALSE |
34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LRRC16A | 0.07 | 0.04 | blup | 288 | 0.03 | 2.8e-04 | -4.7 | -6.0 | 1.4e-09 | 0.14 | 0.02 | 0.96 | TRUE |