Best TWAS P=7.62e-12 · Best GWAS P=2.4e-16 conditioned to 0.00067
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hypothalamus | AC004453.8 | 0.54 | 0.13 | lasso | 7 | 0.16 | 1.8e-04 | -2.7 | -6.7 | 2.3e-11 | 0.61 | 0.03 | 0.51 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | ZMIZ2 | 0.12 | 0.09 | lasso | 4 | 0.06 | 2.3e-05 | -7.2 | -6.7 | 1.7e-11 | 0.66 | 0.18 | 0.79 | FALSE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPIA | 0.05 | 0.02 | enet | 5 | 0.03 | 7.7e-05 | -7.9 | -6.8 | 7.6e-12 | 0.75 | 0.01 | 0.88 | TRUE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | ZMIZ2 | 0.06 | 0.03 | blup | 35 | 0.03 | 3.8e-04 | 5.2 | 5.6 | 2.0e-08 | -0.81 | 0.03 | 0.93 | FALSE |