TWAS
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Traits
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Traits
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Body mass index (BMI)
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chr7:43,821,453-45,498,400
Best TWAS P=7.62e-12 · Best GWAS P=2.4e-16 conditioned to 0.00067
43.8M
44M
44.2M
44.4M
44.6M
44.8M
45M
45.2M
45.4M
0
5
10
15
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
PPIA
0.05
0.02
enet
5
0.03
7.7e-05
-7.9
-6.8
7.6e-12
0.75
0.01
0.88
TRUE
1
GTEx
Brain Hypothalamus
AC004453.8
0.54
0.13
lasso
7
0.16
1.8e-04
-2.7
-6.7
2.3e-11
0.61
0.03
0.51
TRUE
2
GTEx
Cells Transformed fibroblasts
ZMIZ2
0.12
0.09
lasso
4
0.06
2.3e-05
-7.2
-6.7
1.7e-11
0.66
0.18
0.79
FALSE
4
The Cancer Genome Atlas
Thyroid Carcinoma
ZMIZ2
0.06
0.03
blup
35
0.03
3.8e-04
5.2
5.6
2.0e-08
-0.81
0.03
0.93
FALSE