TWAS hub - NEGR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1260	0.0480	0.00079	0.036	NA	0.030	NA	0.050	2.7e-03	NA	6.0e-03	NA	5.1e-04
2	ROSMAP	Brain Pre-frontal Cortex	0.2377	0.0477	0.00000	0.153	0.169	0.186	0.193	0.219	3.1e-19	3.4e-21	2.8e-23	3.4e-24	1.3e-27
3	TCGA	Brain Lower Grade Glioma	0.0598	0.0275	0.00830	0.025	0.011	0.015	NA	0.021	6.0e-04	1.9e-02	7.2e-03	NA	1.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Body Mass Index (BMI) (2010)	20.9	28.6	54.9	5.5	7.4	-0.3
Comparative body size at age 10	19.0	52.5	114.5	6.5	10.7	0.3
Qualifications: College or University degree	13.5	42.6	99.8	4.6	10.0	2.6
Intelligence (Savage-Jansen 2018)	13.4	41.2	104.0	3.9	10.2	2.1
BMI	12.4	71.7	130.0	9.2	11.4	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	12.1	18.4	43.8	3.3	6.6	0.7
Verbal and Numeric Reasoning (VNR)	11.6	27.9	74.4	2.8	8.6	1.3
Major Depression (MDD)	11.5	13.9	29.2	3.5	5.4	-0.5
Age when periods started (menarche)	11.1	26.5	58.0	-4.3	-7.6	-1.8
Long-standing illness, disability or infirmity	10.6	16.2	26.1	5.1	4.7	0.4
Leg fat mass (left)	10.4	40.5	72.7	7.0	8.5	-0.5
Leg fat mass (right)	10.0	38.7	70.9	6.7	8.4	-0.7
Leg fat percentage (left)	9.6	34.8	60.6	6.6	7.8	-0.6
Body mass index (BMI)	9.4	40.2	71.7	7.0	8.5	-0.5
Qualifications: nursing, teaching	9.4	14.6	37.2	2.5	6.1	0.5
Leg fat percentage (right)	9.1	33.1	59.7	6.2	7.7	-0.9
Arm fat mass (left)	8.6	35.4	67.2	6.2	8.2	-0.4
Arm fat mass (right)	8.5	34.9	65.8	6.2	8.1	-0.5
Fluid intelligence score	8.3	17.2	41.1	2.9	6.4	1.4
Whole body fat mass	8.3	34.5	63.7	6.3	8.0	-0.4
Number of self-reported non-cancer illnesses	8.0	13.9	28.2	3.0	5.3	2.1
Hip circumference	7.9	33.9	61.9	6.3	7.9	-0.5
Waist circumference	7.7	28.1	49.4	5.7	7.0	-1.5
Arm fat percentage (left)	7.7	30.6	60.5	5.6	7.8	-0.6
Body fat percentage	7.6	29.9	54.8	5.9	7.4	-0.6
Commuting to job workplace: Car/motor vehicle	7.4	8.4	17.1	-2.8	-4.1	-0.6
Arm fat percentage (right)	7.3	28.8	55.1	5.5	7.4	-0.9
Alcohol intake versus 10 years previously	6.9	10.3	21.0	3.2	4.6	-0.0
Taking other prescription medications	6.8	10.5	14.4	3.5	3.8	2.2
Qualifications: None of the above	6.8	14.5	38.8	-1.8	-6.2	-1.1
Number of treatments/medications taken	6.7	12.1	16.3	3.5	4.0	2.9
Weight	6.7	32.7	58.2	6.3	7.6	-0.5
Trunk fat mass	6.6	28.3	50.8	5.8	7.1	-0.4
Other serious medical condition/disability diagnosed by doctor	6.5	8.4	14.2	2.8	3.8	1.8
Falls in the last year	6.3	8.5	11.4	3.4	2.9	2.5
Commuting to job workplace: Public transport	5.9	7.1	17.5	1.5	4.2	1.2
High blood pressure	5.8	16.1	25.1	4.8	5.0	0.8
Pulse rate, automated reading	5.7	18.3	31.1	4.5	5.6	1.8
Smoking status: Previous	5.6	8.4	14.8	3.9	3.2	-0.1
Number of operations (self-reported)	5.6	8.3	15.1	2.9	3.9	1.0
Trunk fat percentage	5.5	21.9	39.4	5.1	6.3	-0.4
Medication for cholesterol, blood pressure or diabetes	5.5	9.1	13.2	-3.4	-3.6	-1.6
Alcohol usually taken with meals	5.4	8.7	19.4	2.5	4.4	0.7
Multivitamins +/- minerals	5.3	6.8	14.5	1.7	3.8	1.7
Cardiovascular Disease	5.1	17.0	27.0	4.7	5.2	1.4
Severe depression (siblings)	5.0	5.6	10.4	2.5	3.2	0.1
Vitamin and mineral supplements	4.9	6.7	13.7	-1.7	-3.7	-1.8
Commuting to job workplace: Cycle	4.9	6.0	14.1	1.8	3.8	0.6
Average weekly beer plus cider intake	4.8	6.9	14.9	-0.9	-3.9	-2.2
Allergy or Eczema	4.6	12.0	23.9	2.3	4.9	2.6
Hypertension (Self-reported)	4.5	12.6	19.0	4.4	4.3	0.5
Vascular/heart problems diagnosed by doctor	4.5	12.3	18.1	-4.1	-4.2	-1.5
Qualifications: A levels/AS levels or equivalent	4.4	9.8	28.7	0.7	5.4	0.3
Supplements: Zinc	4.3	4.7	6.6	1.5	2.6	2.3
Impedance of arm (right)	4.3	19.8	32.8	-5.1	-5.7	-0.8
Average weekly red wine intake	4.2	6.2	12.8	2.3	3.6	0.7
Stomach or abdominal pain in last month	4.1	5.1	11.4	1.8	3.4	0.8
Mouth/teeth dental problems: Dentures	4.1	6.8	13.6	-2.4	-3.7	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	4.1	5.3	12.7	1.6	3.6	-0.9
Arm fat-free mass (left)	4.1	20.6	35.0	5.1	5.9	-0.6
Arm predicted mass (left)	4.1	20.7	35.0	5.2	5.9	-0.4
Respiratory disease	3.9	8.8	12.1	3.3	3.5	1.9
Hayfever, allergic rhinitis or eczema	3.9	8.4	17.2	1.7	4.2	2.2
Allergy	3.9	8.9	16.2	-1.6	-4.0	-2.8
Impedance of arm (left)	3.9	18.1	28.1	-5.3	-5.1	-0.3
Arm fat-free mass (right)	3.9	20.2	36.0	5.0	6.0	-0.1
Arm predicted mass (right)	3.8	19.4	35.9	4.7	6.0	-0.2
Leg fat-free mass (left)	3.7	19.6	36.1	4.7	6.0	-0.8
Medication: Blood pressure	3.7	6.6	11.2	2.7	3.4	1.2
Leg predicted mass (left)	3.6	19.1	35.6	4.6	6.0	-0.8
Alcohol intake frequency.	3.6	8.4	17.4	2.6	4.2	-1.1
Basal metabolic rate	3.6	20.1	35.3	5.0	5.9	-0.6
Ever depressed for a whole week	3.6	4.5	6.8	2.6	2.1	-1.5
Friendships satisfaction	3.5	4.4	8.0	0.8	2.8	2.1
Asthma (self-reported)	3.5	7.0	8.4	2.1	2.9	2.8
Osteoarthritis (self-reported)	3.5	4.6	10.4	1.5	3.2	1.0
Impedance of whole body	3.5	17.6	29.9	-4.8	-5.5	-0.1
Relative age of first facial hair	3.4	6.9	14.0	-2.6	-3.7	0.2
Mouth/teeth dental problems	3.4	5.2	10.0	2.0	3.2	-1.3
Ever had prostate specific antigen (PSA) test	3.4	4.0	8.1	1.9	2.9	0.4
Asthma	3.3	6.4	8.2	2.1	2.9	2.6
Commuting to job workplace: Walk	3.3	3.5	8.0	1.4	2.8	-0.8
Leg predicted mass (right)	3.3	17.5	31.6	4.5	5.6	-0.6
Triglycerides	3.2	5.3	8.4	2.9	2.5	1.1
Leg fat-free mass (right)	3.2	16.9	31.0	4.4	5.6	-0.6
Wears glasses or contact lenses	3.2	3.7	5.1	2.1	2.3	1.3
Current tobacco smoking	3.0	4.9	12.5	-1.4	-3.5	-0.6
Irritability	3.0	5.1	12.0	3.5	1.8	-0.3
Lung FEV1/FVC ratio	2.9	14.6	34.8	-2.6	-5.9	-1.4
Medication: Atenolol	2.8	3.5	5.5	2.3	2.0	-1.0
Time employed in main current job	2.8	3.2	5.3	-0.6	-2.0	-2.3
Medication: Gliclazide	2.8	3.2	7.8	0.8	1.0	-2.8
Whole body water mass	2.8	16.2	28.7	4.4	5.4	-0.6
Supplements: Calcium	2.8	3.1	4.8	0.9	2.2	1.9
Age at First Birth	2.7	4.0	8.0	1.3	1.5	2.8
Impedance of leg (right)	2.7	13.0	24.2	-3.8	-4.9	0.3
Hayfever/allergic rhinitis (self-reported)	2.7	3.5	6.1	1.2	2.5	1.8
Whole body fat-free mass	2.7	15.6	27.7	4.3	5.3	-0.6
Mineral and other dietary supplements	2.7	3.7	5.5	-1.1	-2.4	-2.1
Smoking status: Current	2.7	4.2	10.4	-1.5	-3.2	-0.1
Breast Cancer	2.6	6.2	10.9	2.8	3.3	0.4
High blood pressure (mother)	2.6	3.7	9.2	0.4	1.3	-3.0
Past tobacco smoking	2.6	4.8	10.8	-3.3	-1.9	-0.3
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	7.4	1.0	1.1	2.7
Average weekly spirits intake	2.5	3.0	6.9	-1.3	-2.6	-0.8
Maternal smoking around birth	2.4	3.5	4.8	2.2	1.8	1.6
Relative age voice broke	2.4	3.6	7.2	-1.7	-2.7	-1.0
Impedance of leg (left)	2.4	11.8	23.0	-3.5	-4.8	0.6
Number of incorrect matches in round	2.4	3.9	6.7	2.0	2.6	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	5.8	1.6	2.4	-0.3
Family relationship satisfaction	2.4	3.0	5.8	1.6	2.4	0.8
Financial situation satisfaction	2.4	2.9	5.2	-0.5	-2.3	-1.9
Medication: Cholesterol lowering	2.3	3.5	5.2	2.3	2.0	1.1
Breastfed as a baby	2.3	2.8	4.1	-2.0	-0.8	-2.0
Wheeze or whistling in the chest in last year	2.3	4.1	7.1	2.7	1.8	1.3
Eye problems/disorders: Cataract	2.3	2.7	4.9	-1.1	-2.2	-1.4
Illnesses of father: None of the above (group 1)	2.3	2.8	6.9	-0.9	-2.6	-0.8
Supplements: Glucosamine	2.2	2.9	4.0	2.0	2.0	1.0
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.5	5.2	2.3	1.0	-2.1
Length of working week for main job	2.2	2.4	5.6	-2.4	-1.1	-0.6
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	6.3	-1.3	-2.5	-0.8
Emphysema/chronic bronchitis	2.2	2.5	5.1	2.2	1.5	-0.2
Illnesses of father: Heart disease	2.2	3.1	8.8	0.7	3.0	0.2
Fractured/broken bones in last 5 years	2.2	2.8	4.2	2.0	2.0	0.5
Pain experienced in last month	2.2	3.6	5.5	-2.3	-2.3	-0.0
Pulse wave Arterial Stiffness index	2.1	2.4	5.7	-1.2	-2.4	0.3
Pulse wave peak to peak time	2.1	2.5	5.9	1.2	2.4	-0.3
Medication: Simvastatin	2.0	2.9	5.7	1.5	2.4	0.7
Hearing aid user	2.0	2.3	4.5	-1.0	-1.1	2.1
Type 2 Diabetes (T2D) (2012)	1.9	2.2	5.0	2.2	1.1	-0.7
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	3.5	1.9	1.8	-0.5
Trunk predicted mass	1.9	10.7	18.5	3.6	4.3	-0.6
Health satisfaction	1.9	2.4	3.7	1.9	1.2	-1.4
Knee pain experienced in last month	1.9	3.0	4.7	2.2	2.1	-0.3
Handedness (chirality/laterality): Left-handed	1.9	2.3	4.2	1.3	2.0	-0.9
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.1	1.2	1.2	-2.0
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	2.8	1.3	1.3	1.7
Trunk fat-free mass	1.8	10.5	17.5	3.7	4.2	-0.6
Medication for pain relief, constipation, heartburn	1.8	3.1	3.4	-1.6	-1.9	-1.8
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	4.3	-1.8	2.1	0.7
Glaucoma (self-reported)	1.7	2.0	3.2	1.8	1.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	6.0	-2.5	-1.9	-1.2
HDL Cholesterol	1.6	2.7	5.0	-1.7	-2.2	0.5
Medication: Paracetamol	1.6	2.7	3.4	1.3	1.7	1.9
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.8	1.9	0.7	1.4
Guilty feelings	1.6	2.4	4.5	0.6	2.1	-1.5
Diabetes (father)	1.5	1.9	3.0	1.1	1.7	1.2
Fed-up feelings	1.5	2.8	4.8	-0.1	-2.2	-1.9
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	4.5	1.0	2.1	-0.1
Medication: Amlodipine	1.5	2.1	4.8	0.9	2.2	-0.8
Illnesses of father: High blood pressure	1.5	1.8	4.5	0.8	2.1	0.6
Heel T-Score	1.4	11.4	27.8	2.4	5.3	0.6
Neuroticism	1.4	3.5	6.9	2.6	0.8	-1.7
Sensitivity / hurt feelings	1.4	2.4	6.8	0.5	-2.6	-0.3
Medication: Levothyroxine sodium	1.4	2.4	4.1	1.4	1.1	2.0
Had other major operations	1.4	1.8	2.7	1.7	1.5	0.5
Birth weight of first child	1.4	2.5	5.3	2.3	1.4	0.6
Number of children fathered	1.4	1.6	2.6	-0.1	-1.6	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	2.9	-1.1	-1.7	-0.9
Osteoporosis (self-reported)	1.4	1.7	4.0	1.1	2.0	0.1
Alzheimer’s Disease (in mother)	1.3	1.5	2.2	1.5	1.2	-0.9
Systolic Blood Pressure	1.3	6.6	11.1	-3.3	-3.0	-0.1
Nervous feelings	1.3	2.5	4.9	-0.2	-2.2	-1.6
Diabetes (self-reported)	1.3	2.0	2.9	1.7	1.5	-0.9
Medication: Lansoprazole	1.3	1.5	1.9	1.3	0.9	-1.4
Illnesses of mother	1.3	1.7	3.6	-0.5	-1.1	1.9
Gout (self-reported)	1.3	1.7	4.1	0.7	0.8	-2.0
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.5	1.6	1.2	0.7
Had major operations	1.3	1.5	2.3	1.5	1.5	0.3
Medication: Lisinopril	1.3	1.6	2.7	1.6	1.4	-0.3
Prostate Cancer	1.2	1.7	2.8	1.7	1.5	-0.4
Crohns Disease (2012)	1.2	2.0	4.5	-1.2	-2.1	0.1
Medication: Metformin	1.2	1.7	2.4	1.5	1.5	-0.8
Exposure to tobacco smoke at home	1.2	1.4	2.4	-0.5	-1.2	-1.6
Illnesses of siblings: Diabetes	1.2	1.5	3.6	0.9	1.9	0.1
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.5	0.2	1.5	1.6
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.7	0.6	-0.6	1.9
Alcohol drinker status: Previous	1.2	1.4	2.2	1.4	1.5	0.2
Coronary Artery Disease (CAD)	1.1	1.3	3.8	-0.0	0.1	-2.0
Financial difficulties in last 2 years	1.1	1.5	4.4	-0.2	-0.2	-2.1
Pain all over the body in last month	1.1	1.2	3.4	-0.1	0.3	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	3.1	-1.2	-1.5	-1.8
Schizophrenia (2018)	1.0	2.1	6.2	-0.4	2.5	0.0
Neuroticism (2016)	1.0	1.5	4.0	2.0	0.4	0.5
Chronotype (morning person)	1.0	2.3	3.7	-1.0	1.5	1.9
Townsend deprivation index at recruitment	1.0	1.5	2.7	1.1	-0.6	-1.6
Qualifications: CSEs or equivalent	1.0	1.3	3.2	0.3	-1.8	0.8
Heart attack	1.0	1.2	3.2	0.6	-0.5	1.8
Worrier / anxious feelings	1.0	1.9	4.0	2.0	1.3	0.0
Tense / ‘highly strung’	1.0	1.7	1.9	1.4	1.2	-1.4
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	2.2	1.5	1.5	1.2
Medication: Ibuprofen	1.0	1.2	3.3	0.4	1.8	-0.3
Heart disease (mother)	1.0	1.2	3.1	-0.1	0.6	1.8
Supplements: Vitamin C	1.0	1.1	1.5	1.1	1.2	0.9
Ovarian Cancer	0.9	1.2	3.2	0.3	-0.6	1.8
Hypothyroidism (self reported)	0.9	2.1	3.2	1.6	1.8	0.8
Diabetes (mother)	0.9	1.2	3.5	0.3	1.9	0.2
Noisy workplace	0.9	1.1	2.9	-0.1	-1.7	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.5	-1.2	-0.2	-1.2
Lung cancer (father)	0.9	1.0	1.9	0.7	0.8	-1.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.8	0.9	-0.8	-1.4
High blood pressure (siblings)	0.9	1.3	3.4	0.7	1.8	0.0
Mood swings	0.9	1.6	2.8	1.2	-1.7	0.7
Ever had bowel cancer screening	0.9	1.0	1.4	0.8	1.2	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.5	1.1	1.2	0.3
Risk taking	0.9	1.3	4.0	-2.0	0.2	-0.1
Myopia	0.9	1.4	3.3	-0.9	1.8	0.1
Basal cell carcinoma (self-reported)	0.9	1.1	1.6	0.3	1.3	1.3
Bipolar Disorder or Schizophrenia	0.8	1.9	5.3	0.3	2.3	-0.5
Systolic blood pressure, automated reading	0.8	2.3	5.6	-2.4	-1.1	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.5	1.1	1.6	-0.1
Peak expiratory flow (PEF)	0.8	1.9	4.8	2.2	0.4	0.8
Shortness of breath walking on level ground	0.8	0.9	1.8	1.3	-1.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.2	1.1	1.1	0.5
Medication: Blood pressure	0.8	1.5	3.3	1.8	1.0	-0.3
Schizophrenia (2014)	0.7	1.5	3.4	0.6	1.8	-0.9
Waist Hip Ratio (WHR)	0.7	3.2	4.8	-0.9	-2.2	-1.9
Type 2 Diabetes (T2D) (2018)	0.7	1.2	1.7	1.3	1.3	-0.7
Hearing difficulty/problems with background noise	0.7	1.1	2.8	0.4	-0.7	-1.7
Neuroticism score	0.7	1.5	2.9	1.7	0.5	-1.2
Happiness	0.7	0.9	1.4	0.7	1.2	-0.8
Pulse wave reflection index	0.7	0.8	2.4	-0.0	-1.6	-0.0
Loud music exposure frequency	0.7	0.8	1.8	0.6	-1.3	-0.5
Medication: Allopurinol	0.7	1.0	2.0	0.9	0.4	-1.4
Overall health rating	0.7	1.4	2.1	1.4	0.9	1.2
Diabetes diagnosed by doctor	0.7	1.2	2.0	1.4	0.9	-0.9
Ever smoked	0.7	1.3	3.8	2.0	-0.2	-0.3
Alzheimer’s Disease (including proxy)	0.6	0.8	1.2	0.8	-0.8	-1.1
Smoking Status	0.6	1.3	2.0	0.9	-1.1	-1.4
Hearing difficulty/problems: Yes	0.6	0.9	1.3	1.1	0.7	-1.0
Hair/balding pattern: Pattern 2	0.6	0.8	1.8	-1.4	-0.5	0.6
Pulse rate	0.6	1.0	2.3	0.2	1.5	0.8
Age at first live birth	0.6	1.0	2.5	-1.6	0.2	-0.8
Medication: Omeprazole	0.6	0.7	1.0	0.8	0.7	1.0
Number of full sisters	0.6	0.8	1.3	1.1	1.0	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.1	0.9	1.0	0.6
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	1.2	0.9	0.0
High cholesterol (Self-reported)	0.6	1.1	1.5	1.2	0.6	1.2
Medication: Paracetamol	0.6	0.9	1.5	0.6	1.0	1.2
Alcohol drinker status: Never	0.6	0.7	1.5	-0.7	1.2	-0.3
Worry (Nagel 2018)	0.5	1.1	1.6	1.2	0.4	-1.3
Alzheimer’s Disease (in father)	0.5	0.5	1.2	-0.6	-1.1	0.2
Rheumatoid Arthritis	0.5	0.7	1.4	0.4	-1.2	-0.7
Angina	0.5	0.7	2.0	1.4	0.3	-0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.2	0.7	1.1	0.1
Angina (self-reported)	0.5	0.6	1.8	1.3	0.2	0.1
Migraine (self-reported)	0.5	0.6	1.5	-1.2	0.1	0.4
Comparative height size at age 10	0.5	2.6	6.2	0.6	2.5	1.1
Ever taken oral contraceptive pill	0.5	0.6	1.0	0.4	1.0	0.8
Medication: Atorvastatin	0.5	0.6	1.1	0.2	-0.7	1.1
Age started oral contraceptive pill	0.5	0.6	0.9	0.3	1.0	0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.4	1.2	0.4	0.6
Bipolar Disorder (2018)	0.4	0.6	0.8	0.9	0.6	-0.9
Depressed Affect (Nagel 2018)	0.4	0.8	1.9	0.2	-1.4	-0.6
Neuroticism (Nagel 2018)	0.4	1.0	1.8	1.1	-0.3	-1.3
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	0.9	0.7	0.5
Crohns Disease (2017)	0.4	0.9	1.6	-0.2	-1.0	1.3
Reaction Time	0.4	0.8	1.8	0.1	0.8	-1.3
HbA1C	0.4	0.5	1.2	0.4	0.1	-1.1
Blood White Count	0.4	2.6	4.8	-2.2	-0.7	-1.6
Tanning	0.4	4.8	11.4	-1.4	-3.4	0.9
Average weekly fortified wine intake	0.4	0.5	0.7	-0.8	0.0	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.5	-0.0	-0.1	-1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	0.9	0.6	0.4
Hair/balding pattern: Pattern 3	0.4	0.6	1.7	0.3	-0.4	-1.3
Number of live births	0.4	0.6	1.8	0.3	-1.3	0.1
Medication: Seretide 50 evohaler	0.4	0.4	1.2	1.1	0.4	0.0
Suffer from ‘nerves’	0.4	0.6	0.9	-0.9	-0.7	-0.7
Medication for cholesterol	0.4	0.6	1.4	-1.2	-0.7	-0.1
Breast cancer (self-reported)	0.4	0.5	1.3	-0.3	-1.1	-0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	-0.8	-0.5	-0.8
Irritable Bowel Disease (IBD)	0.3	0.8	1.3	0.4	-1.1	1.0
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.4	0.2	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.9	0.2	-0.7	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	0.3	0.1	1.1
Ever had hysterectomy (womb removed)	0.3	0.4	0.6	-0.2	-0.7	0.8
Chronic bronchitis/emphysema (father)	0.3	0.3	0.5	-0.7	0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.1	0.8	1.1	0.1
Medication: Ramipril	0.3	0.4	1.0	1.0	-0.4	-0.3
Illnesses of siblings	0.3	0.4	0.5	0.5	-0.7	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.4	-0.1	-1.6	-0.4
Headache pain in last month	0.3	0.5	1.6	-0.0	-0.1	1.2
Exposure to tobacco smoke outside home	0.3	0.3	0.5	-0.4	-0.7	0.6
Number of full brothers	0.3	0.4	1.1	-1.1	-0.2	0.0
Worry too long after embarrassment	0.3	0.5	0.7	-0.1	-0.8	-0.8
Mean time to correctly identify matches	0.3	0.6	1.6	0.2	1.3	0.0
Chest pain or discomfort	0.3	0.4	0.8	-0.9	-0.0	0.6
Leg pain on walking	0.3	0.4	0.5	0.7	0.4	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	-0.1	0.9	0.8
Back pain experienced in last month	0.3	0.5	1.0	0.6	-1.0	-0.2
Average weekly champagne plus white wine intake	0.3	0.4	1.0	1.0	-0.4	-0.2
Medication: Bendroflumethiazide	0.3	0.5	1.1	1.0	0.7	0.1
Unable to work because of sickness or disability	0.3	0.4	0.6	0.8	0.7	-0.5
Cholesterol lowering medication	0.3	0.4	0.7	0.4	0.7	0.8
Ulcerative Colitis	0.2	0.2	0.5	0.4	-0.7	-0.1
Hand grip strength (left)	0.2	0.6	1.6	0.5	-0.2	-1.3
Medication: Co-codamol	0.2	0.2	0.6	0.8	-0.2	0.1
Pack years adult smoking proportion	0.2	0.4	0.7	-0.5	-0.9	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.1	-0.3	1.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.5	-0.4	0.3	-0.7
Father’s age at death	0.2	0.2	0.4	0.1	0.6	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.2	0.2	-1.5	-0.2
Hair/balding pattern: Pattern 4	0.2	0.6	0.9	0.9	0.9	-0.3
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.1	0.4	0.7
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.7	0.3	-0.3
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.9	-0.1	-0.3
Loneliness, isolation	0.2	0.2	0.6	-0.0	-0.1	-0.8
Miserableness	0.2	0.4	0.7	0.7	-0.8	-0.0
Mother’s age at death	0.2	0.3	0.4	0.2	0.6	-0.7
Pack years of smoking	0.2	0.3	0.5	-0.6	-0.7	0.3
Ulcerative Colitis (UC)	0.1	0.2	0.2	0.5	-0.5	-0.0
Mean Putamen Volume	0.1	0.1	0.4	0.0	0.0	-0.7
Fasting Glucose	0.1	0.1	0.3	-0.2	-0.6	-0.1
LDL Cholesterol	0.1	0.2	0.4	-0.4	0.0	-0.6
Blood Eosinophil Count	0.1	0.5	0.8	0.6	0.7	-0.9
Blood Platelet Count	0.1	1.4	1.6	-1.3	-1.2	-1.0
Height	0.1	1.3	1.5	1.1	-1.2	1.1
Lung FVC	0.1	0.5	1.4	-0.1	-0.1	1.2
Hair Pigment	0.1	2.2	6.4	-0.4	-2.5	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.3	0.2	-0.3
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.6	0.3	-0.0
Hand grip strength (right)	0.1	0.3	0.5	0.4	0.4	-0.7
Sitting height	0.1	0.9	1.5	-1.1	-1.2	-0.1
Had menopause	0.1	0.1	0.2	-0.3	-0.1	-0.4
Forced vital capacity (FVC)	0.1	0.5	0.9	0.2	-0.9	0.8
Prospective memory result	0.1	0.1	0.2	0.3	0.4	-0.0
Standing height	0.1	0.8	1.6	-0.9	-1.2	0.0
Forced vital capacity (FVC), Best measure	0.1	0.3	0.8	-0.2	-0.9	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	-0.3	-0.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.3	0.0	-0.4
Age at last live birth	0.1	0.1	0.2	-0.4	0.4	-0.1
Medication: Aspirin	0.1	0.1	0.1	0.4	0.2	-0.2
Diastolic blood pressure, automated reading	0.1	0.4	0.4	-0.6	0.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	0.1	0.4	0.6
Heart disease (siblings)	0.1	0.1	0.1	-0.3	0.3	-0.3
Depression (Nagel 2018)	0.0	0.0	0.0	0.2	0.2	-0.1
Lupus	0.0	0.0	0.1	0.3	-0.2	-0.1
Primary Biliary Cirrhosis	0.0	0.1	0.1	0.1	0.3	0.3
Blood Red Count	0.0	0.3	0.8	0.5	0.0	-0.9
Depression (self-reported)	0.0	0.1	0.2	-0.1	0.0	0.4
Birth weight	0.0	0.1	0.1	0.3	-0.0	0.3
Medication: Aspirin	0.0	0.0	0.1	0.2	0.3	-0.0

Hub : Genes

NEGR1

Models

Trait associations