Best TWAS P=2.1e-09 · Best GWAS P=1.57e-10 conditioned to 0.00318
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cortex | NRBF2 | 0.30 | 0.26 | enet | 24 | 0.21 | 1.4e-06 | 4.9 | 5.5 | 3.1e-08 | -0.52 | 0.30 | 0.68 | FALSE |
2 | GTEx | Brain Frontal Cortex BA9 | NRBF2 | 0.25 | 0.17 | lasso | 6 | 0.16 | 6.1e-05 | -5.4 | 5.8 | 7.7e-09 | -0.54 | 0.22 | 0.62 | FALSE |
3 | GTEx | Stomach | NRBF2 | 0.09 | 0.04 | lasso | 6 | 0.03 | 1.6e-02 | 3.4 | 5.1 | 2.9e-07 | -0.46 | 0.05 | 0.59 | FALSE |
4 | GTEx | Testis | NRBF2 | 0.14 | 0.08 | lasso | 12 | 0.09 | 6.7e-05 | -5.3 | 5.6 | 2.5e-08 | -0.52 | 0.48 | 0.40 | FALSE |
5 | NTR | Blood | NRBF2 | 0.03 | 0.01 | bslmm | 386 | 0.01 | 3.4e-05 | -2.5 | -5.2 | 2.3e-07 | 0.30 | 0.19 | 0.08 | FALSE |
6 | ROSMAP | Brain Pre-frontal Cortex | NRBF2 | 0.34 | 0.46 | lasso | 5 | 0.46 | 3.1e-66 | -5.4 | 5.7 | 1.2e-08 | -0.55 | 0.49 | 0.51 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NRBF2 | 0.05 | 0.06 | lasso | 2 | 0.06 | 5.5e-12 | -5.4 | 5.5 | 4.7e-08 | -0.55 | 0.26 | 0.74 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NRBF2 | 0.04 | 0.04 | enet | 5 | 0.03 | 1.3e-04 | -5.4 | 5.6 | 1.9e-08 | -0.51 | 0.16 | 0.42 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NRBF2 | 0.10 | 0.06 | lasso | 7 | 0.08 | 3.5e-09 | 4.7 | 5.5 | 2.9e-08 | -0.44 | 0.63 | 0.37 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NRBF2 | 0.08 | 0.08 | enet | 6 | 0.08 | 4.3e-09 | -5.4 | 5.6 | 2.0e-08 | -0.57 | 0.26 | 0.74 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NRBF2 | 0.09 | 0.02 | enet | 6 | 0.04 | 1.4e-05 | 2.9 | 5.2 | 2.1e-07 | -0.51 | 0.39 | 0.38 | FALSE |
12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NRBF2 | 0.18 | 0.13 | enet | 11 | 0.08 | 2.5e-04 | -5.4 | 6.0 | 2.1e-09 | -0.73 | 0.03 | 0.90 | TRUE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NRBF2 | 0.08 | 0.09 | lasso | 6 | 0.08 | 9.7e-09 | -5.4 | 5.6 | 2.8e-08 | -0.52 | 0.26 | 0.74 | FALSE |