Best TWAS P=1.96e-08 · Best GWAS P=2.4e-09 conditioned to 0.000185
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | VCL | 0.12 | 0.12 | lasso | 9 | 0.12 | 1.2e-15 | 5 | -5.3 | 1.1e-07 | -0.43 | 0.02 | 0.97 | FALSE |
| 2 | YFS | Blood | VCL | 0.07 | 0.03 | blup | 251 | 0.06 | 2.3e-18 | 5 | -5.6 | 2.0e-08 | -0.48 | 0.11 | 0.89 | TRUE |
| 3 | The Cancer Genome Atlas | Thyroid Carcinoma | VCL | 0.08 | 0.02 | blup | 57 | 0.05 | 7.6e-06 | 5 | -5.2 | 2.6e-07 | -0.47 | 0.01 | 0.97 | FALSE |