TWAS
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About
Usage
Models
Genes
Traits
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Traits
:
Body mass index (BMI)
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chr10:75,064,567-76,568,774
Best TWAS P=1.96e-08 · Best GWAS P=2.4e-09 conditioned to 0.000185
75M
75.2M
75.4M
75.6M
75.8M
76M
76.2M
76.4M
76.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
YFS
Blood
VCL
0.07
0.03
blup
251
0.06
2.3e-18
5
-5.6
2.0e-08
-0.48
0.11
0.89
TRUE
1
ROSMAP
Brain Pre-frontal Cortex
VCL
0.12
0.12
lasso
9
0.12
1.2e-15
5
-5.3
1.1e-07
-0.43
0.02
0.97
FALSE
3
The Cancer Genome Atlas
Thyroid Carcinoma
VCL
0.08
0.02
blup
57
0.05
7.6e-06
5
-5.2
2.6e-07
-0.47
0.01
0.97
FALSE