TWAS hub - VCL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0730	0.0310	2.4e-06	0.047	0.051	0.057	0.052	0.061	2.1e-06	7.8e-07	1.6e-07	5.1e-07	6.0e-08
2	GTEx	Artery Aorta	0.1750	0.0590	3.5e-06	0.055	NA	0.086	NA	0.093	5.3e-04	NA	1.8e-05	NA	7.9e-06
3	GTEx	Artery Tibial	0.0850	0.0424	5.5e-03	0.026	NA	0.027	NA	0.021	3.5e-03	NA	3.4e-03	NA	8.4e-03
4	GTEx	Cells Transformed fibroblasts	0.0690	0.0350	2.3e-03	0.021	NA	0.037	NA	0.033	1.0e-02	NA	8.0e-04	NA	1.5e-03
5	GTEx	Esophagus Muscularis	0.0490	0.0270	8.9e-03	-0.003	NA	-0.004	NA	-0.004	6.0e-01	NA	7.4e-01	NA	6.8e-01
6	GTEx	Whole Blood	0.0820	0.0410	7.4e-03	0.031	NA	0.000	NA	0.006	7.2e-04	NA	3.0e-01	NA	8.9e-02
7	ROSMAP	Brain Pre-frontal Cortex	0.1238	0.0347	6.7e-14	0.119	0.113	0.120	0.112	0.124	4.5e-15	2.7e-14	4.0e-15	3.7e-14	1.2e-15
8	YFS	Blood	0.0655	0.0209	5.6e-17	0.033	0.058	0.051	0.056	0.056	6.5e-11	2.3e-18	3.4e-16	7.6e-18	1.1e-17
9	TCGA	Breast Invasive Carcinoma	0.0186	0.0104	1.3e-03	0.003	0.014	0.008	NA	0.007	6.3e-02	5.7e-04	8.1e-03	NA	1.2e-02
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0429	0.0255	2.0e-03	0.008	0.013	0.003	NA	0.011	3.9e-02	1.2e-02	1.4e-01	NA	1.8e-02
11	TCGA	Lung Adenocarcinoma	0.0372	0.0233	5.6e-03	0.033	0.012	0.018	NA	0.025	8.7e-05	1.2e-02	3.1e-03	NA	5.8e-04
12	TCGA	Prostate Adenocarcinoma	0.0837	0.0364	1.5e-06	0.060	0.067	0.053	NA	0.061	7.0e-07	1.5e-07	3.0e-06	NA	5.6e-07
13	TCGA	Thyroid Carcinoma	0.0760	0.0360	2.3e-05	0.023	0.052	0.046	NA	0.039	2.3e-03	7.7e-06	2.8e-05	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Worry (Nagel 2018)	6.7	14.1	25.1	-0.5	4.7	4.8	4.5	5.0	4.3	4.3	2.7	3.2	1.6	2.3	3.2	4.5
Hearing difficulty/problems with background noise	5.3	8.5	25.8	5.1	3.7	3.1	1.8	-0.8	2.6	2.8	3.8	3.8	0.7	1.6	1.7	2.9
Exposure to tobacco smoke outside home	5.3	7.1	13.7	0.4	-2.0	-2.8	-2.6	-3.3	-1.7	-1.9	-1.4	-3.1	-3.3	-3.0	-3.7	-3.3
Tense / ‘highly strung’	5.2	8.6	18.4	-0.8	3.7	4.0	3.3	4.3	3.4	3.3	1.8	2.3	1.2	1.6	2.3	3.4
Eye problems/disorders: None of the above	4.9	5.7	12.4	2.1	2.4	2.8	2.8	0.9	3.0	3.1	3.5	2.4	0.3	1.2	1.5	2.7
Worrier / anxious feelings	4.6	8.7	17.5	-1.0	3.9	3.7	3.2	4.2	3.2	3.1	1.9	2.7	1.7	1.8	2.6	3.5
Impedance of leg (left)	4.5	22.1	34.6	3.7	5.6	4.2	3.8	1.6	3.6	4.2	4.5	5.9	4.4	5.7	5.9	5.8
BMI	4.4	25.7	42.4	-4.5	-5.6	-4.9	-5.2	-2.1	-5.4	-6.1	-6.5	-5.8	-2.3	-5.1	-4.5	-5.8
Impedance of leg (right)	4.4	21.4	33.3	3.3	5.8	4.5	4.1	2.0	3.8	4.4	4.5	5.6	4.0	5.3	5.5	5.8
Body mass index (BMI)	4.4	18.8	31.6	-3.3	-4.9	-4.3	-4.4	-1.8	-5.0	-5.3	-5.6	-4.6	-1.7	-4.5	-3.6	-5.2
Nervous feelings	4.0	7.4	13.8	-0.5	3.3	3.6	3.3	3.7	2.8	3.1	2.0	2.4	1.4	1.4	2.4	3.3
Worry too long after embarrassment	4.0	6.8	16.7	-1.1	3.2	4.1	3.5	2.8	3.6	3.4	2.4	0.9	-0.6	0.9	0.8	2.9
Eye problems/disorders: Cataract	4.0	4.6	8.5	-1.0	-2.6	-2.4	-2.4	-1.6	-2.9	-2.6	-2.4	-2.1	-0.4	-1.5	-1.7	-2.7
Birth weight of first child	3.8	7.0	11.7	0.5	3.4	3.0	2.9	3.2	2.8	3.1	2.0	2.9	1.3	1.8	2.5	3.1
Waist circumference	3.7	13.5	20.2	-2.1	-3.9	-3.5	-3.5	-2.1	-4.2	-4.3	-4.4	-4.0	-2.1	-4.4	-3.5	-4.5
Neuroticism (Nagel 2018)	3.6	8.6	17.1	-0.5	3.6	3.8	3.7	3.7	4.1	4.0	2.7	1.8	-0.3	0.6	1.3	3.2
Neuroticism score	3.6	7.4	14.3	0.1	3.4	3.8	3.2	3.4	3.8	3.7	2.7	1.8	-0.4	0.2	1.0	3.0
Financial situation satisfaction	3.6	4.5	7.0	-1.2	-2.5	-1.8	-2.1	-2.0	-2.1	-2.2	-1.8	-2.6	-1.6	-2.1	-2.4	-2.6
Medication: Omeprazole (e.g. Zanprol)	3.6	4.4	12.3	0.7	2.1	1.7	0.9	1.5	0.3	0.7	0.2	2.8	3.5	2.6	3.5	2.4
Body Mass Index (BMI) (2010)	3.5	4.9	8.6	-2.6	-2.0	-2.0	-1.6	-0.2	-2.1	-2.0	-2.8	-2.9	-1.3	-2.5	-2.3	-2.7
Arm fat mass (right)	3.4	13.9	21.5	-2.5	-4.0	-3.2	-3.6	-1.6	-4.2	-4.4	-4.6	-4.1	-2.0	-4.5	-3.5	-4.5
Arm fat mass (left)	3.4	14.2	21.3	-2.5	-4.0	-3.3	-3.7	-1.9	-4.2	-4.4	-4.6	-4.3	-2.2	-4.4	-3.6	-4.6
Impedance of whole body	3.4	17.3	28.1	4.5	5.3	4.4	3.5	0.5	3.8	4.3	5.0	4.8	2.3	4.4	3.9	4.9
Hair/balding pattern: Pattern 2	3.3	4.2	10.8	1.5	2.0	2.6	2.4	0.3	2.9	2.8	3.3	1.5	-0.7	1.4	0.5	1.9
Current tobacco smoking	3.2	5.2	11.7	-2.4	-3.4	-2.0	-1.8	-0.7	-2.2	-2.4	-2.7	-2.9	-1.0	-2.2	-2.0	-2.5
Neuroticism	3.1	7.4	15.1	0.8	3.5	3.5	3.0	3.1	3.9	3.8	3.0	2.1	-0.3	0.4	1.2	2.9
Leg fat-free mass (left)	3.1	16.7	30.7	-3.5	-4.4	-3.2	-2.9	-1.3	-3.0	-3.5	-3.8	-5.4	-4.1	-5.5	-5.2	-5.1
Leg predicted mass (left)	3.1	16.6	30.0	-3.5	-4.4	-3.2	-2.9	-1.4	-3.1	-3.5	-3.8	-5.3	-4.0	-5.5	-5.1	-5.0
Pulse rate, automated reading	3.1	10.2	23.1	-1.0	-3.0	-2.8	-4.8	-2.6	-4.5	-4.7	-4.1	-2.9	0.0	-1.6	-1.8	-3.5
Weight	3.0	14.8	21.6	-2.9	-4.2	-3.5	-3.7	-1.7	-4.0	-4.3	-4.5	-4.4	-2.4	-4.6	-3.8	-4.7
Lung FEV1/FVC ratio	2.9	14.6	40.7	-2.4	5.0	4.4	3.5	6.4	2.1	2.8	-0.1	3.6	4.2	2.6	4.7	4.0
Noisy workplace	2.9	3.5	7.3	0.6	-2.2	-2.3	-1.8	-2.7	-1.8	-1.7	-0.9	-1.7	-1.3	-2.3	-2.0	-2.1
Wheeze or whistling in the chest in last year	2.9	5.1	11.8	-2.1	-3.1	-2.0	-2.1	-0.8	-3.1	-3.4	-3.4	-1.6	0.8	-1.4	-0.6	-2.1
Whole body fat mass	2.9	12.0	18.6	-2.1	-3.6	-3.1	-3.4	-1.9	-4.1	-4.3	-4.3	-3.8	-1.7	-3.9	-3.1	-4.2
Leg fat mass (right)	2.9	11.2	21.2	-2.7	-3.4	-3.2	-3.3	-1.4	-4.1	-4.3	-4.6	-3.5	-1.0	-3.5	-2.5	-4.0
Leg fat-free mass (right)	2.9	15.4	27.6	-3.1	-4.4	-3.1	-2.8	-1.5	-2.8	-3.3	-3.5	-5.1	-4.1	-5.2	-5.1	-4.9
Leg predicted mass (right)	2.9	15.5	26.8	-3.2	-4.4	-3.2	-2.9	-1.5	-2.9	-3.4	-3.5	-5.2	-4.0	-5.2	-5.0	-4.9
Leg fat mass (left)	2.9	11.2	20.6	-2.4	-3.5	-3.3	-3.4	-1.6	-4.1	-4.3	-4.5	-3.4	-1.0	-3.5	-2.5	-4.0
Medication: Omeprazole	2.8	3.3	9.7	0.6	2.1	1.1	0.7	1.2	0.3	0.7	0.0	2.6	3.1	2.2	3.1	2.0
Arm fat percentage (right)	2.7	10.8	18.1	-1.7	-3.4	-2.7	-3.2	-1.7	-3.9	-4.3	-4.2	-3.5	-1.6	-3.8	-3.1	-4.0
Knee pain experienced in last month	2.7	4.2	12.0	3.3	2.4	1.6	1.3	-0.5	2.6	2.3	3.5	2.0	-0.6	0.8	0.5	1.9
Arm fat percentage (left)	2.7	10.9	17.4	-1.8	-3.4	-2.7	-3.2	-1.8	-3.9	-4.2	-4.2	-3.6	-1.7	-3.8	-3.1	-4.1
Smoking status: Current	2.7	4.3	11.0	-2.7	-3.3	-1.7	-1.4	-0.3	-2.2	-2.3	-2.6	-2.5	-0.4	-1.6	-1.4	-2.1
Systolic blood pressure, automated reading	2.6	7.7	37.5	-6.1	-3.4	-1.1	0.3	2.8	-1.9	-1.9	-4.3	-2.8	0.1	-1.9	-1.0	-1.8
Hip circumference	2.6	11.0	15.9	-2.3	-3.4	-3.4	-3.5	-1.7	-3.5	-3.8	-3.9	-3.6	-1.9	-3.9	-3.1	-4.0
Illnesses of father: None of the above (group 1)	2.6	3.2	12.7	3.6	2.3	0.7	-0.1	-1.2	1.6	2.1	2.6	2.1	0.0	0.3	0.8	1.6
Trunk fat mass	2.5	10.6	17.1	-1.7	-3.2	-2.7	-3.2	-1.9	-3.6	-3.8	-3.7	-3.6	-2.1	-4.1	-3.3	-4.0
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	11.6	-1.5	1.6	1.8	2.0	3.4	2.9	2.7	1.4	-0.2	-1.9	-1.7	-1.0	1.1
Mouth/teeth dental problems: Bleeding gums	2.5	3.3	7.4	1.4	2.7	2.0	0.7	0.8	1.1	1.0	1.4	2.2	2.0	2.1	2.3	2.2
Leg fat percentage (right)	2.4	8.6	20.9	-2.1	-2.7	-2.9	-3.4	-1.3	-4.3	-4.3	-4.6	-2.3	0.8	-2.0	-0.9	-3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	13.1	-1.9	1.5	1.8	2.4	3.6	2.2	2.1	0.6	0.4	-0.5	-0.3	0.1	1.3
Basal metabolic rate	2.4	13.3	21.6	-3.4	-4.1	-3.1	-2.9	-1.1	-3.1	-3.6	-3.9	-4.6	-3.0	-4.6	-4.1	-4.5
Leg fat percentage (left)	2.4	8.8	20.1	-1.6	-2.8	-3.2	-3.7	-1.6	-4.4	-4.5	-4.5	-2.0	0.9	-1.9	-0.8	-3.1
Arm fat-free mass (left)	2.4	12.4	17.6	-3.6	-4.1	-3.4	-3.1	-0.7	-3.4	-3.7	-4.2	-4.2	-2.1	-4.1	-3.4	-4.2
Comparative body size at age 10	2.3	6.3	11.5	-1.6	-2.9	-1.9	-1.9	-1.6	-3.4	-3.4	-3.2	-2.5	-1.0	-2.4	-2.4	-3.1
Suffer from ‘nerves’	2.3	3.6	10.3	-1.1	1.9	2.4	2.5	3.2	2.6	2.6	1.4	0.4	-1.2	-0.6	-0.2	1.4
Commuting to job workplace: Public transport	2.3	2.8	7.0	0.7	1.5	2.6	1.6	1.4	2.4	2.2	2.0	1.7	-0.2	0.4	0.5	1.9
Myopia	2.3	3.4	8.0	0.9	2.5	1.7	2.5	1.4	2.7	2.8	2.4	0.8	-1.6	0.3	-0.4	0.9
Arm predicted mass (left)	2.3	11.6	16.5	-3.5	-4.0	-3.2	-2.9	-0.8	-3.3	-3.6	-4.0	-4.1	-2.0	-4.0	-3.3	-4.1
Fasting Glucose	2.2	2.6	6.7	-0.7	-1.4	-2.6	-1.8	-1.2	-1.0	-1.2	-1.2	-1.6	-1.6	-2.0	-1.8	-2.0
Impedance of arm (right)	2.2	10.2	18.2	4.3	4.1	3.7	2.7	-0.2	3.2	3.4	4.3	3.5	0.7	2.5	2.1	3.5
Impedance of arm (left)	2.2	10.4	19.4	4.3	4.2	3.5	2.7	-0.4	3.2	3.5	4.4	3.4	0.7	2.9	2.1	3.5
Whole body water mass	2.2	12.7	21.3	-3.6	-4.1	-3.1	-2.6	-0.8	-2.8	-3.3	-3.7	-4.6	-3.0	-4.4	-4.1	-4.3
Fed-up feelings	2.1	3.9	10.0	0.5	1.7	2.6	1.6	2.0	3.2	3.1	2.5	0.9	-1.4	-0.8	-0.1	2.1
Pulse rate	2.1	3.5	7.2	0.3	-1.5	-1.4	-2.7	-2.0	-2.3	-2.1	-1.7	-1.9	-1.0	-2.2	-2.0	-2.0
Mouth/teeth dental problems: Dentures	2.1	3.5	5.9	-1.1	-2.2	-1.9	-1.9	-0.5	-2.1	-1.9	-2.4	-1.9	-0.9	-2.4	-1.8	-2.2
Body fat percentage	2.1	8.4	15.1	-1.2	-2.8	-2.5	-3.1	-1.9	-3.8	-3.9	-3.8	-2.8	-0.9	-3.2	-2.3	-3.5
Health satisfaction	2.1	2.7	7.4	-1.1	-1.2	-0.6	-1.1	-0.5	-0.4	-0.6	-1.0	-2.2	-2.6	-2.7	-2.6	-1.6
Whole body fat-free mass	2.1	12.1	20.2	-3.5	-4.0	-3.0	-2.5	-0.8	-2.8	-3.2	-3.6	-4.5	-2.9	-4.3	-4.0	-4.2
Hearing difficulty/problems: Yes	2.0	3.0	21.6	4.6	1.4	0.6	0.0	-3.0	0.1	0.1	2.1	1.4	-0.2	0.1	0.0	0.4
Townsend deprivation index at recruitment	2.0	2.8	12.0	-0.0	-1.1	-0.7	-0.5	-1.0	1.0	0.7	0.8	-2.0	-3.5	-2.3	-2.9	-1.3
Arm fat-free mass (right)	2.0	10.0	16.7	-3.5	-3.7	-3.0	-2.2	-0.7	-2.7	-2.9	-3.4	-4.1	-2.4	-3.8	-3.4	-3.8
Arm predicted mass (right)	2.0	10.3	16.9	-3.7	-3.8	-3.1	-2.4	-0.7	-2.7	-3.0	-3.5	-4.1	-2.3	-3.7	-3.2	-3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	5.5	1.0	1.3	1.3	0.6	0.4	0.7	1.0	1.1	2.0	1.9	2.3	2.4	1.8
Friendships satisfaction	2.0	2.5	8.4	0.1	-0.6	-0.3	-1.2	-2.0	-0.1	-0.1	0.1	-2.3	-2.9	-1.9	-2.8	-1.3
Depressed Affect (Nagel 2018)	1.9	3.9	10.4	1.2	2.4	2.0	1.9	1.4	3.2	3.1	2.7	1.2	-1.5	-0.2	0.0	1.9
Coronary Artery Disease (CAD)	1.9	2.3	4.3	-0.1	-2.1	-1.9	-1.5	-1.9	-1.5	-1.7	-0.9	-1.8	-1.2	-0.7	-1.7	-1.6
Mean Putamen Volume	1.9	2.1	5.6	-0.5	1.3	1.1	2.3	2.4	1.9	1.8	0.9	1.1	0.4	0.8	1.1	1.7
Systolic Blood Pressure	1.9	9.4	55.8	-7.5	-3.2	0.3	1.5	4.7	-0.8	-0.9	-3.6	-3.1	-0.6	-1.9	-1.4	-1.0
Number of full sisters	1.9	2.4	10.4	3.2	0.5	-1.1	-0.6	-1.9	0.7	0.9	1.6	0.2	-2.0	-2.1	-1.7	-0.5
Osteoarthritis (self-reported)	1.9	2.5	9.3	-1.7	0.0	0.0	-1.1	1.5	-1.1	-1.5	-1.8	0.9	3.0	2.0	2.3	0.7
Reaction Time	1.8	3.4	17.2	4.1	1.8	-0.2	0.7	-1.3	1.5	1.7	2.8	2.3	0.1	0.6	0.8	1.2
Ulcerative Colitis	1.8	2.6	7.0	0.4	-1.6	-1.3	-2.4	-2.7	-2.4	-2.3	-1.5	-0.9	0.6	-0.4	-0.5	-1.3
Financial difficulties in last 2 years	1.8	2.4	6.2	-1.4	-1.6	-1.0	-0.6	-0.0	-0.2	-0.6	-0.7	-2.5	-2.4	-2.3	-2.3	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	11.6	-2.5	1.4	2.3	2.0	3.4	1.4	1.5	0.1	0.3	0.3	0.1	0.8	1.4
Medication: Blood pressure	1.8	3.4	15.7	-4.0	-2.1	-0.7	-0.6	2.2	-1.5	-1.8	-3.0	-1.5	0.8	-0.6	0.0	-1.2
Number of operations (self-reported)	1.8	2.7	6.5	0.3	-1.0	-0.8	-2.2	-0.8	-2.3	-2.5	-2.3	1.0	2.5	0.8	1.5	-0.5
Bipolar Disorder (2018)	1.7	2.7	10.1	-2.1	1.7	1.8	2.6	3.2	1.4	1.6	0.3	0.8	0.4	-0.3	0.7	1.6
Depression (Nagel 2018)	1.7	2.5	9.1	-1.2	-0.3	0.3	0.6	1.8	1.2	1.0	0.2	-1.6	-3.0	-2.7	-2.4	-0.7
Trunk fat percentage	1.7	6.8	11.7	-0.7	-2.3	-2.0	-2.9	-1.9	-3.1	-3.1	-3.0	-2.7	-1.6	-3.4	-2.6	-3.2
Stomach or abdominal pain in last month	1.7	2.1	8.5	-2.9	0.6	2.1	1.7	2.8	0.7	0.6	-0.8	-0.2	0.7	-0.1	0.7	1.1
Length of working week for main job	1.7	1.9	5.8	-0.4	-0.9	-0.9	-0.2	-0.9	-0.3	-0.8	-0.4	-1.9	-2.4	-1.6	-2.2	-1.9
Bipolar Disorder or Schizophrenia	1.6	4.0	9.3	-0.3	2.4	2.6	3.0	2.5	2.5	2.7	1.8	1.4	-0.1	0.0	0.7	2.1
Medication: Co-codamol	1.6	1.9	6.9	0.2	-0.7	-0.9	-1.8	0.0	-1.8	-1.7	-1.6	1.0	2.6	0.9	1.6	-0.1
Relative age voice broke	1.6	2.5	7.2	2.6	1.4	1.2	1.5	-1.0	2.1	1.8	2.7	0.8	-1.4	0.2	-0.4	1.0
Commuting to job workplace: Cycle	1.6	2.0	5.6	-0.0	-1.8	-0.7	-0.8	-0.9	-0.6	-0.8	-0.3	-1.9	-2.1	-1.9	-2.4	-1.7
Allergy or Eczema	1.5	3.9	7.6	1.2	1.4	2.0	1.5	1.4	2.6	2.3	2.5	2.4	0.9	1.8	1.8	2.8
Pack years adult smoking proportion	1.5	2.2	4.3	-1.2	-2.1	-0.7	-1.7	-1.0	-1.4	-1.6	-1.6	-1.9	-0.9	-1.7	-1.5	-1.6
Chronic bronchitis/emphysema (father)	1.5	1.8	5.1	-1.3	-1.5	-0.8	-1.2	-0.6	-1.6	-2.3	-2.1	-0.8	1.3	1.1	0.3	-0.7
Trunk fat-free mass	1.5	8.5	13.9	-3.3	-3.5	-2.6	-1.9	-0.4	-2.4	-2.8	-3.2	-3.7	-2.1	-3.5	-3.1	-3.5
Father’s age at death	1.5	1.9	4.4	-0.6	1.3	1.7	-0.2	1.8	0.8	0.9	0.2	1.5	1.8	2.1	1.8	1.6
Hair/balding pattern: Pattern 3	1.5	2.3	6.9	0.1	-1.2	-1.5	-2.6	-1.1	-2.4	-2.0	-2.0	0.1	1.3	-0.5	0.3	-1.2
Trunk predicted mass	1.5	8.4	13.5	-3.3	-3.5	-2.6	-2.0	-0.4	-2.5	-2.8	-3.2	-3.7	-2.1	-3.5	-3.0	-3.5
Mean time to correctly identify matches	1.5	2.8	16.0	4.0	1.6	-0.7	0.3	-1.3	1.3	1.5	2.4	2.2	-0.1	-0.0	0.4	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	7.4	-0.8	-0.8	-0.3	-0.3	1.5	0.7	0.7	-0.2	-1.4	-2.4	-2.7	-2.0	-0.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.8	-1.1	1.1	2.0	1.3	2.2	1.2	1.3	0.2	0.4	0.3	-0.7	0.4	1.4
Medication: Lansoprazole	1.4	1.6	4.1	-0.6	0.6	1.8	0.4	1.5	-0.0	0.0	-0.5	1.4	2.0	1.5	2.0	1.3
Medication: Amlodipine	1.4	2.0	8.0	-2.8	-1.3	-0.0	-0.1	1.3	-0.6	-0.9	-1.9	-1.9	-0.9	-1.5	-1.3	-1.1
Age at first live birth	1.4	2.4	5.9	0.2	1.2	1.3	1.0	1.2	0.7	0.9	1.0	2.2	2.4	2.0	2.4	1.7
Miserableness	1.4	2.5	7.2	1.7	1.7	1.4	1.0	0.2	2.6	2.1	2.7	1.1	-1.2	0.3	0.0	1.4
Hearing aid user	1.4	1.5	6.2	0.8	-0.9	-1.2	-2.5	-1.4	-1.8	-1.6	-1.1	0.2	0.8	-0.3	-0.0	-1.0
Illnesses of father: High blood pressure	1.4	1.8	9.5	-2.6	-0.3	0.5	2.3	3.1	0.4	0.5	-0.3	-0.8	-0.2	-0.3	-0.2	-0.1
Alzheimer’s Disease (in mother)	1.3	1.5	3.9	0.2	-1.4	-2.0	-1.6	-1.4	-1.3	-1.7	-1.0	-0.8	-0.0	-0.6	-0.5	-1.5
Cardiovascular Disease	1.3	4.5	24.3	-4.9	-1.4	0.5	0.8	3.1	-1.4	-1.7	-3.5	-1.2	1.6	-0.3	0.5	-0.6
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.3	-1.7	0.5	0.7	0.5	2.1	1.3	1.2	0.1	-1.0	-2.0	-2.1	-1.5	-0.1
Relative age of first facial hair	1.3	2.6	10.8	3.3	0.9	0.2	0.6	-1.6	0.7	0.8	2.2	2.1	1.3	1.6	1.7	1.3
Average weekly fortified wine intake	1.3	1.5	6.1	-2.5	-1.6	-0.5	-0.9	-0.0	-1.2	-1.0	-1.7	-1.5	-0.0	-0.4	-0.7	-1.1
Medication: Blood pressure	1.3	2.3	11.8	-1.8	0.9	1.9	1.8	3.4	0.7	0.8	-0.4	0.7	1.4	-0.3	1.2	1.5
Loneliness, isolation	1.3	1.9	8.1	-1.9	0.5	1.5	1.4	2.9	1.6	1.5	0.1	-0.5	-0.8	-1.0	-0.4	0.8
Back pain experienced in last month	1.3	1.9	3.8	-0.3	-1.6	-1.9	-0.7	-1.7	-1.5	-1.6	-1.2	-1.6	-0.8	-0.5	-1.2	-1.8
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.0	-0.0	-1.1	-1.7	-0.8	-1.7	-1.1	-0.9	-0.6	-1.7	-1.1	-0.9	-1.5	-1.7
Fractured/broken bones in last 5 years	1.3	1.7	3.3	-1.6	-1.5	-1.1	-0.7	0.6	-1.0	-1.1	-1.4	-1.8	-0.9	-1.4	-1.4	-1.6
Vascular/heart problems diagnosed by doctor	1.3	3.5	16.2	4.0	1.5	-0.2	-0.3	-2.8	1.3	1.4	3.2	1.0	-1.3	1.2	-0.3	0.5
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.6	-1.2	-0.8	-1.2	-1.9	-0.4	-1.3	-1.4	-1.6	-1.7	-0.3	-0.6	-0.6	-1.1
Severe depression (siblings)	1.2	1.4	3.8	-0.9	-0.7	-1.1	-0.7	0.0	-0.5	-0.2	-0.8	-1.5	-1.6	-1.9	-1.9	-1.4
Hayfever, allergic rhinitis or eczema	1.2	2.7	5.1	1.4	1.2	1.7	0.7	0.4	1.9	1.5	2.1	1.8	1.1	2.2	1.8	2.3
High blood pressure (mother)	1.2	1.7	8.3	-2.6	0.0	1.5	1.6	2.9	0.1	0.4	-1.0	-0.3	0.4	0.0	0.3	0.3
Qualifications: A levels/AS levels or equivalent	1.2	2.6	6.3	-1.3	1.5	2.5	1.7	1.7	1.4	1.0	0.7	1.1	1.6	2.1	1.7	2.0
Leg pain on walking	1.2	1.5	2.4	-0.1	-1.4	-1.0	-0.6	-1.3	-1.0	-1.2	-0.7	-1.5	-1.4	-1.5	-1.6	-1.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	4.6	1.7	0.8	1.1	0.6	0.0	0.4	0.7	0.7	2.2	1.5	0.9	1.5	1.4
Mood swings	1.2	2.2	5.8	0.8	2.4	1.6	1.5	1.1	2.0	2.1	1.7	1.3	-0.3	0.1	0.7	1.6
Pack years of smoking	1.2	1.8	3.1	-0.9	-1.8	-0.9	-1.5	-1.0	-1.2	-1.3	-1.3	-1.6	-0.9	-1.7	-1.4	-1.4
Schizophrenia (2018)	1.1	2.3	4.5	1.3	1.7	2.1	1.8	0.7	2.1	2.1	2.1	1.2	-0.4	0.3	0.4	1.4
Schizophrenia vs Biploar Disorder	1.1	1.4	7.6	2.8	-0.2	-0.9	-0.6	-2.4	0.3	0.5	1.6	0.3	-1.0	-0.3	-0.5	0.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.6	-1.9	-0.4	-0.4	-1.1	1.7	-1.4	-0.9	-1.9	-0.1	1.2	-0.5	0.6	-0.5
Medication: Atenolol	1.1	1.4	4.7	-2.2	-0.8	-0.3	-0.0	0.6	-0.6	-0.5	-1.2	-1.8	-1.1	-1.7	-1.3	-1.1
Had other major operations	1.1	1.4	3.9	-0.9	-0.9	-1.1	-2.0	-0.7	-1.5	-1.7	-1.7	-0.4	1.1	0.3	0.7	-0.8
Fluid intelligence score	1.1	2.3	6.5	-2.0	0.7	1.6	0.4	1.3	-0.3	-0.8	-1.2	0.7	2.4	2.6	2.1	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	5.6	2.2	0.3	-0.3	0.3	-1.3	1.4	0.9	1.6	-0.1	-2.4	-1.9	-1.6	-0.2
Hypertension (Self-reported)	1.1	3.0	14.0	-3.7	-1.1	0.1	0.7	3.2	-0.9	-0.9	-2.8	-0.8	1.0	-1.4	0.3	-0.4
Osteoporosis (self-reported)	1.1	1.4	3.5	1.2	1.5	0.6	0.8	-0.1	1.6	1.8	1.9	0.9	0.1	1.0	0.7	1.3
Intelligence (Savage-Jansen 2018)	1.0	3.2	9.0	0.7	2.3	1.9	1.0	1.1	1.2	0.8	0.7	1.9	2.1	3.0	2.6	2.0
Major Depression (MDD)	1.0	1.2	3.4	-1.7	-1.2	-0.6	-0.7	0.1	-1.3	-1.5	-1.8	-1.2	0.1	-0.1	-0.4	-1.1
Number of treatments/medications taken	1.0	1.8	4.6	-0.3	1.5	2.1	1.1	2.0	0.9	0.8	0.1	1.5	1.5	0.6	1.6	1.7
Supplements: Zinc	1.0	1.1	3.6	-0.9	0.9	0.9	1.9	1.7	1.3	1.2	0.8	0.0	-0.2	0.2	0.2	1.0
Diabetes (mother)	1.0	1.3	5.7	-0.5	1.9	1.3	2.4	1.1	1.1	1.0	0.5	0.6	0.4	0.7	0.7	0.9
Taking other prescription medications	1.0	1.5	4.8	-1.2	0.8	0.8	0.1	1.9	-0.2	-0.1	-1.2	1.2	2.2	0.9	1.9	1.1
High blood pressure	1.0	2.9	13.1	-3.6	-0.7	0.7	1.0	3.5	-0.6	-0.7	-2.6	-0.5	1.2	-0.9	0.6	-0.1
Medication: Ramipril	1.0	1.3	3.3	-0.2	-1.5	-1.1	-1.7	-0.1	-1.6	-1.8	-1.6	-0.5	0.8	-0.2	0.0	-1.0
Illnesses of mother	1.0	1.3	4.8	1.3	0.8	1.1	0.2	-0.3	1.7	1.7	2.2	0.8	-0.5	0.5	0.4	1.1
Peak expiratory flow (PEF)	1.0	2.2	6.5	-0.3	-0.2	-0.8	-0.9	-1.6	-0.5	-0.7	-0.6	-2.4	-2.5	-1.5	-2.4	-1.9
Pulse wave reflection index	1.0	1.3	3.6	1.6	1.1	0.4	0.2	-0.5	0.2	0.3	0.7	1.8	1.3	1.9	1.5	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.5	-0.7	-0.7	-1.5	-1.4	0.1	-1.5	-1.3	-1.6	0.4	1.5	0.7	1.0	-0.8
Medication: Gliclazide	1.0	1.1	3.3	-1.3	-0.7	-0.5	-0.0	0.5	-0.2	-0.2	-0.8	-1.3	-1.6	-1.8	-1.4	-1.2
Verbal and Numeric Reasoning (VNR)	0.9	2.1	10.3	-0.3	1.1	1.3	0.4	0.5	-0.0	-0.5	-0.4	1.1	2.3	3.2	2.3	0.9
Bipolar Disorder (2011)	0.9	0.8	3.9	-1.6	0.7	0.5	1.4	2.0	0.4	0.8	-0.2	0.3	0.3	-0.1	0.4	0.4
Medication: Metformin	0.9	1.2	4.1	-1.9	-0.3	-0.7	-0.9	1.0	-1.1	-0.9	-2.0	-0.9	-0.1	-1.2	-0.6	-1.1
Pulse wave Arterial Stiffness index	0.9	1.0	3.5	0.6	-0.7	-1.2	-1.9	-1.2	-1.2	-1.4	-1.0	-0.2	0.1	-0.6	-0.3	-0.8
Headache pain in last month	0.9	1.5	4.1	2.0	1.9	0.4	-0.6	0.3	1.2	1.4	1.6	1.5	0.1	0.7	0.7	1.3
Pulse wave peak to peak time	0.9	1.0	3.5	-0.8	0.6	1.3	1.9	1.3	1.2	1.3	1.0	0.0	-0.1	0.6	0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.3	-0.9	-1.4	-0.7	-1.0	-1.2	-0.5	-0.7	-0.4	-2.1	-2.0	-1.7	-2.1	-1.7
Qualifications: nursing, teaching	0.9	1.4	4.3	-1.4	0.4	0.6	-0.0	0.9	-0.6	-0.5	-0.8	0.8	2.1	2.0	1.9	0.7
Number of self-reported non-cancer illnesses	0.9	1.5	7.7	-2.0	0.4	1.0	0.8	2.8	0.3	-0.0	-1.3	0.5	1.2	0.0	1.2	0.9
Irritability	0.9	1.5	3.9	0.9	1.9	1.3	0.1	0.6	2.0	1.5	1.4	1.2	0.0	0.4	0.8	1.6
Age started oral contraceptive pill	0.9	1.1	3.4	-1.3	-0.9	-1.4	-0.7	-0.0	-1.5	-1.3	-1.8	-0.5	1.2	-0.0	0.4	-0.7
Cholesterol lowering medication	0.9	1.3	2.7	-0.7	-1.6	-1.3	-1.3	-0.4	-1.4	-1.5	-1.5	-1.0	0.0	-0.9	-0.6	-1.3
Smoking Status	0.8	1.9	4.9	-1.4	-2.2	-0.8	-0.6	-0.5	-1.3	-1.4	-1.7	-1.8	-0.6	-1.6	-1.3	-1.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	-0.7	-1.2	-0.3	-1.2	0.0	-1.2	-1.4	-1.4	-0.6	-0.0	-0.9	-0.7	-1.0
Happiness	0.8	0.9	3.4	0.1	0.3	0.0	0.4	0.2	1.0	1.0	0.8	-0.7	-1.8	-1.8	-1.4	-0.1
Breastfed as a baby	0.8	1.0	4.4	-0.2	0.2	-0.6	0.9	0.7	-0.5	-0.1	-0.3	1.0	2.1	1.4	1.7	0.5
Number of children fathered	0.8	0.9	3.4	-1.9	-0.7	-0.3	-1.1	0.2	-0.8	-1.3	-1.4	-1.1	0.4	0.8	-0.1	-0.8
Emphysema/chronic bronchitis	0.8	0.9	2.8	-1.1	-0.7	-0.3	0.2	1.6	0.2	0.2	-1.0	-0.9	-1.1	-1.7	-1.1	-0.6
Long-standing illness, disability or infirmity	0.8	1.2	3.4	-1.0	-1.3	-0.9	-1.1	0.2	-1.2	-1.4	-1.8	-1.2	-0.3	-1.0	-0.8	-1.0
Average weekly champagne plus white wine intake	0.8	1.0	4.2	-0.4	-1.2	-1.0	-2.0	-1.1	-0.9	-0.7	-0.4	-1.1	-0.7	-0.5	-1.0	-1.2
Medication: Lisinopril	0.8	1.1	3.8	-0.6	0.7	1.2	1.1	1.9	0.7	0.8	-0.0	1.3	1.0	-0.8	0.9	1.3
Alzheimer’s Disease (including proxy)	0.7	1.0	2.6	0.9	-0.5	-1.5	-1.6	-1.4	-1.0	-1.2	-0.4	0.4	1.0	0.5	0.8	-0.4
Irritable Bowel Disease (IBD)	0.7	1.6	7.8	2.0	-0.3	-0.9	-1.7	-2.8	-0.8	-1.2	0.0	-0.1	0.9	1.2	0.6	-0.3
Schizophrenia (2014)	0.7	1.6	3.4	1.2	1.4	1.1	1.9	0.5	1.7	1.9	1.9	0.9	-0.7	-0.0	0.1	1.0
Triglycerides	0.7	1.1	2.6	-0.6	-1.0	-0.9	-1.3	-0.8	-0.4	-0.5	-0.5	-1.6	-1.4	-1.0	-1.5	-1.0
Blood Platelet Count	0.7	7.9	35.3	-5.9	0.4	2.4	1.9	5.6	0.5	-0.0	-1.9	-0.2	2.7	2.5	2.4	1.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.3	-0.0	-0.2	0.7	-0.2	0.4	0.1	-0.2	0.1	1.0	1.7	1.4	1.8	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.7	2.0	-1.4	-0.8	-1.0	-0.8	1.1	-0.6	-0.9	-1.3	-0.7	-0.0	-0.4	-0.3	-0.8
Medication: Cholesterol lowering	0.7	1.0	4.5	-0.9	0.3	0.7	0.2	1.0	-0.6	-0.6	-1.1	0.8	2.1	0.9	1.6	0.7
Birth weight	0.7	1.6	4.4	-0.0	0.8	1.5	1.8	0.8	1.2	1.0	0.7	-0.7	-2.1	-2.0	-1.6	0.0
High blood pressure (siblings)	0.7	1.0	5.5	-2.3	-0.6	0.4	0.7	1.9	-0.3	-0.7	-1.2	-0.4	0.7	0.0	0.3	0.1
Number of full brothers	0.7	0.8	2.8	1.0	0.5	-0.2	0.3	-1.0	0.9	1.0	1.5	-0.5	-1.7	-0.6	-1.0	-0.1
Shortness of breath walking on level ground	0.7	0.9	2.3	-0.8	-1.5	0.2	-1.0	-0.9	-0.6	-1.2	-0.7	-1.5	-0.7	-0.3	-1.0	-0.7
Heart disease (mother)	0.7	0.8	2.0	0.5	-0.4	-1.2	-1.1	-0.8	-1.3	-1.4	-0.8	0.5	1.3	0.1	0.6	-0.3
Family relationship satisfaction	0.7	0.8	3.0	0.9	0.0	0.4	0.1	-1.1	0.3	0.7	0.9	-0.5	-1.7	-1.3	-1.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.0	1.3	1.0	0.2	0.6	0.4	1.0	1.0	1.2	1.1	0.4	1.4	0.9	0.8
Medication: Aspirin	0.7	0.9	5.1	-2.2	0.0	0.5	1.0	1.6	-0.2	-0.3	-1.3	-0.5	0.7	0.2	0.4	0.2
Supplements: Vitamin C	0.7	0.9	3.1	1.1	0.3	0.7	-0.1	-1.6	0.4	0.3	0.8	-0.8	-1.8	-0.7	-1.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	4.0	-1.7	0.7	1.1	1.3	2.0	0.8	0.5	0.0	0.4	0.9	0.8	1.0	1.1
Medication: Aspirin	0.7	1.0	4.3	-2.1	0.5	1.1	1.1	1.6	0.0	0.0	-0.9	-0.4	0.8	0.7	0.6	0.6
Guilty feelings	0.7	1.0	4.4	-0.8	0.4	1.1	1.5	2.1	0.9	0.8	0.1	-0.2	-0.8	-1.3	-0.6	0.2
Ulcerative Colitis (UC)	0.6	1.2	4.5	1.1	-0.9	-0.6	-1.8	-2.1	-1.1	-1.6	-0.7	-0.7	0.2	0.1	-0.3	-0.7
Prostate Cancer	0.6	0.8	2.8	-1.7	-1.3	-0.8	-0.5	0.1	-1.0	-1.1	-1.1	-0.9	0.1	-0.0	-0.3	-0.8
Lupus	0.6	1.0	2.3	1.0	0.0	-1.1	-1.0	-1.5	-1.5	-1.2	-1.0	0.2	1.1	0.8	0.6	-0.6
Lung FVC	0.6	3.0	6.0	-2.3	-1.4	-0.5	-0.0	0.5	-1.2	-1.3	-1.9	-2.4	-1.8	-2.1	-2.5	-2.3
Hand grip strength (left)	0.6	1.6	4.9	-1.4	0.3	0.8	-0.6	1.8	-0.1	-0.0	-1.0	0.9	2.2	1.4	2.0	1.1
Medication for hormone replacement therapy	0.6	0.7	2.6	1.6	0.8	0.7	-0.8	-0.4	0.5	0.9	0.9	1.1	0.2	0.3	0.6	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.7	0.6	1.4	1.6	0.6	0.7	0.8	0.5	0.8	1.2	1.2	1.4	1.5	1.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	-1.1	-0.4	-1.2	-1.3	0.0	-0.5	-0.3	-1.1	-0.8	-0.6	-1.2	-0.6	-0.7
Qualifications: None of the above	0.6	1.4	9.1	3.0	-0.2	-0.7	-0.9	-2.1	0.2	0.1	1.2	0.8	-0.3	-0.4	-0.1	0.2
Heart attack	0.6	0.7	2.1	-1.1	-1.2	-0.6	-0.3	0.9	-0.9	-0.8	-1.4	-0.3	0.6	-1.2	0.0	-0.2
Allergy	0.6	1.5	3.6	-1.4	-0.7	-1.3	-1.0	-0.3	-1.8	-1.4	-1.9	-1.1	-0.0	-1.0	-0.7	-1.6
Blood clot in the leg (DVT)	0.6	0.8	2.8	0.9	-0.7	-0.5	-1.0	-0.6	-1.2	-0.8	-0.7	0.4	-0.2	-1.7	-0.6	-1.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.6	1.3	-0.5	-1.2	-0.8	-1.9	0.1	-0.1	0.7	-0.5	-1.4	0.3	-1.0	-0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	0.2	-0.5	-0.3	-0.5	-0.7	-1.4	-1.3	-1.0	0.2	1.3	0.9	0.7	-0.4
Age at last live birth	0.6	0.9	1.9	0.0	0.9	1.0	0.8	1.0	0.5	0.8	0.9	1.1	1.4	1.1	1.2	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.7	-0.4	-1.0	-0.9	-1.6	-0.8	-0.8	-1.1	-0.7	-0.7	0.1	0.2	-0.2	-0.8
Mineral and other dietary supplements	0.6	0.8	5.1	-2.2	-0.6	0.7	0.6	1.4	0.1	0.2	-0.7	-0.9	-0.4	-0.0	-0.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.8	2.0	0.2	-0.4	-0.5	-1.6	-0.5	-0.7	0.3	0.8	0.7	0.6	0.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.9	1.2	-0.6	-0.4	-0.7	-0.8	-1.0	-0.5	-0.4	0.4	-0.3	-1.7	-0.7	-1.0
Alzheimer’s Disease (in father)	0.5	0.6	1.5	0.6	0.8	0.1	-0.0	0.0	0.9	1.2	1.2	1.0	0.1	0.4	0.7	1.0
Crohns Disease (2017)	0.5	1.1	4.4	1.9	0.4	-1.0	-0.5	-2.1	-0.4	-0.4	0.5	0.7	1.2	1.3	1.2	0.1
Breast Cancer	0.5	1.3	4.3	-2.1	-1.1	-0.9	-0.9	-0.0	-1.2	-1.4	-1.7	-1.2	0.8	1.0	0.2	-0.6
Ovarian Cancer	0.5	0.7	3.7	1.9	0.3	-0.3	-0.2	-0.9	-0.0	0.2	0.7	1.2	0.8	0.8	1.0	0.4
Age at First Birth	0.5	0.7	2.4	0.9	0.4	0.3	-0.1	-0.1	0.4	0.1	0.2	1.2	1.5	0.8	1.4	0.9
Rheumatoid Arthritis	0.5	0.6	2.5	-1.6	-0.4	-0.3	0.1	-0.4	-0.8	-1.1	-0.8	-0.7	0.6	1.2	0.3	-0.4
Blood Red Count	0.5	5.0	8.2	-1.3	-2.7	-1.8	-2.2	-2.2	-2.7	-2.5	-2.2	-2.9	-1.3	-1.9	-2.0	-2.7
Hypothyroidism (self reported)	0.5	1.2	3.9	-2.0	-1.1	-0.4	-1.2	0.7	-1.1	-1.4	-1.9	-0.6	1.1	0.5	0.6	-0.4
Sensitivity / hurt feelings	0.5	0.8	1.7	0.1	0.8	0.9	1.0	1.1	1.0	1.2	0.9	0.3	-0.9	-1.3	-0.4	0.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	1.1	0.7	1.0	1.0	0.1	0.3	0.2	0.4	0.8	0.7	0.9	0.8	0.9
Diabetes (father)	0.5	0.7	3.2	-1.8	-0.0	1.1	0.9	1.5	0.4	-0.2	-0.5	-0.7	-0.1	0.2	-0.2	0.5
Serious illness, injury or assault to yourself	0.5	0.6	2.8	-1.6	0.1	0.3	-0.1	1.7	-0.1	-0.4	-1.2	-0.3	0.4	-0.1	0.2	0.1
Supplements: Glucosamine	0.5	0.7	3.9	2.0	0.6	-0.9	-0.9	-1.2	-0.2	-0.2	0.7	0.6	0.0	0.5	0.2	-0.0
Forced vital capacity (FVC)	0.5	1.8	8.0	-0.7	0.3	0.9	0.4	-0.3	0.8	0.6	0.7	-1.8	-2.8	-1.6	-2.4	-0.9
Number of live births	0.5	0.8	1.7	0.8	1.2	0.5	0.1	0.8	0.1	0.7	0.4	1.3	1.3	0.9	1.2	0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.7	-1.2	1.5	1.8	1.1	1.1	1.2	1.1	0.6	-1.2	-2.2	-1.2	-1.7	-0.2
Hair/balding pattern: Pattern 4	0.5	1.3	3.1	0.5	1.4	1.7	1.1	0.9	1.1	1.2	1.1	0.9	0.5	1.2	0.9	1.4
Forced vital capacity (FVC), Best measure	0.5	1.9	7.8	-0.8	-0.3	0.5	0.5	-0.2	0.5	0.2	0.3	-2.1	-2.8	-1.9	-2.5	-1.2
Medication for cholesterol	0.5	0.7	2.7	1.7	1.1	0.1	0.9	-1.1	0.6	0.6	1.4	0.4	-0.6	0.4	-0.3	0.3
Wears glasses or contact lenses	0.5	0.6	1.4	-1.1	-0.0	-0.6	-1.2	1.0	-0.3	-0.3	-1.2	0.3	1.0	0.1	0.9	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.0	-0.2	-1.3	-0.5	-0.3	0.1	-0.8	-1.1	-0.9	-0.6	-0.3	-1.4	-0.9	-0.7
Medication: Bendroflumethiazide	0.5	0.8	3.4	-1.8	-0.8	0.6	-0.3	1.7	-0.5	-0.4	-1.2	-0.4	0.7	-0.7	0.3	-0.1
Medication: Paracetamol	0.5	0.7	3.7	1.9	1.2	0.1	0.4	-0.6	0.9	0.7	1.2	0.4	-0.7	0.3	-0.2	0.4
Diastolic blood pressure, automated reading	0.5	1.4	3.7	-1.0	0.1	1.9	1.0	1.6	0.1	0.2	-0.3	1.0	1.7	1.4	1.6	1.1
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.9	-1.1	-1.2	-0.6	-0.5	0.9	-1.0	-0.8	-1.4	-0.2	0.7	-1.0	0.1	-0.2
Crohns Disease (2012)	0.4	0.7	2.4	1.3	0.4	-1.2	-1.1	-1.6	-0.6	-0.2	0.3	0.4	0.5	0.4	0.4	-0.5
HDL Cholesterol	0.4	0.6	1.3	-0.7	-0.8	-1.1	0.4	-0.8	-0.8	-0.9	-0.5	-0.9	-0.4	-0.5	-0.5	-1.1
Neuroticism (2016)	0.4	0.6	2.8	-1.0	0.2	1.0	0.9	1.7	0.6	0.8	0.1	-0.2	-0.2	-0.6	-0.3	0.4
Average weekly spirits intake	0.4	0.5	2.8	0.7	-0.3	0.5	-0.4	-1.7	-0.2	-0.5	0.1	-1.0	-0.5	0.4	-0.6	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.2	-0.7	-0.8	-1.0	-0.6	-0.4	-0.9	-0.9	-1.1	-0.8	-0.2	-0.7	-0.5	-0.7
Maternal smoking around birth	0.4	0.6	1.4	-1.2	-1.2	-0.7	-0.4	-0.0	-0.6	-1.0	-1.0	-1.1	-0.3	-0.1	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.4	-0.1	1.0	1.0	-0.4	0.3	0.2	-0.1	-0.0	0.8	1.5	1.5	1.5	1.0
Medication: Levothyroxine sodium	0.4	0.7	2.1	-0.0	0.6	0.5	0.5	1.1	-0.1	-0.1	-0.4	1.2	1.5	1.1	1.3	0.7
Mouth/teeth dental problems	0.4	0.6	2.0	0.7	-0.6	-0.4	0.4	-1.1	0.5	0.5	0.8	-0.5	-1.4	0.2	-1.0	-0.5
Illnesses of siblings	0.4	0.6	3.0	1.0	-0.7	-0.5	-1.3	-1.7	-0.6	-0.4	0.4	-0.2	0.0	0.2	-0.2	-0.4
Depression (self-reported)	0.4	0.5	2.9	-1.5	-0.2	0.4	-0.2	1.7	-0.2	-0.2	-0.9	-0.2	0.5	-0.3	0.2	-0.1
Lung cancer (father)	0.4	0.5	2.0	0.0	0.1	0.0	-0.1	-1.4	0.2	0.4	0.3	-0.8	-1.4	-0.4	-1.2	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.2	-1.4	0.6	1.3	0.9	0.9	0.4	0.3	-0.0	-1.6	-1.8	-1.5	-1.7	-0.6
Exposure to tobacco smoke at home	0.4	0.5	1.9	1.4	-0.4	-1.2	-0.3	-0.9	-0.5	-0.1	0.3	0.3	-0.1	-1.1	-0.2	-0.3
Loud music exposure frequency	0.4	0.4	2.1	1.5	-0.3	-0.0	0.8	-1.2	0.1	-0.0	0.8	-0.2	-0.4	-0.4	-0.5	-0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	3.3	-1.8	0.1	1.1	1.1	1.4	0.3	0.0	-0.5	-0.3	0.1	0.2	0.1	0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	1.0	0.5	0.6	1.0	-0.4	0.6	0.6	0.7	1.0	0.2	0.7	0.6	0.6
Qualifications: College or University degree	0.4	1.4	6.0	-2.4	0.3	1.9	0.9	1.7	0.5	-0.3	-0.7	-0.5	0.8	1.4	0.7	0.8
Overall health rating	0.4	0.8	3.3	-1.2	0.1	1.1	0.1	1.6	0.5	0.3	-0.3	-0.5	-1.0	-1.8	-0.9	0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	0.5	1.0	-1.0	0.2	-0.2	-0.2	-0.1	0.1	0.6	0.8	1.0	1.0	0.1
Illnesses of father: Heart disease	0.4	0.5	1.3	-1.1	-0.8	-0.8	-0.1	0.2	-0.9	-1.1	-1.1	-0.5	0.2	-0.1	-0.1	-0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	-0.1	0.8	1.1	-0.8	0.8	0.2	0.5	-0.2	0.9	0.8	-0.1	0.5	0.8
Breast cancer (self-reported)	0.4	0.5	1.5	0.2	1.0	0.6	1.2	0.7	0.6	0.6	0.3	0.9	0.4	-0.1	0.6	0.9
Mother’s age at death	0.4	0.5	2.9	-1.7	-0.4	-0.6	0.3	-0.1	-0.4	-0.1	-0.6	-1.0	-0.6	-0.8	-0.8	-0.5
Heart disease (siblings)	0.4	0.5	1.1	0.7	-0.2	-0.9	-0.1	-0.9	-0.1	-0.2	-0.1	-0.5	-1.0	-1.0	-0.9	-0.7
LDL Cholesterol	0.3	0.4	1.8	-0.4	0.1	-0.1	-0.0	-0.4	0.2	0.3	0.3	-1.1	-1.4	-0.8	-1.1	-0.5
Blood Eosinophil Count	0.3	2.2	13.0	-3.6	-1.5	0.2	0.9	2.8	0.4	0.4	-1.0	-1.3	-0.7	-1.0	-0.6	-0.3
Respiratory disease	0.3	0.7	2.1	0.1	-1.4	-0.2	0.6	-0.8	0.3	-0.2	0.4	-1.1	-1.5	-1.0	-1.4	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.5	3.2	-1.8	0.7	-0.0	0.0	1.2	0.3	-0.0	-0.9	-0.4	0.1	-0.1	0.3	-0.0
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.5	-0.8	0.2	0.4	0.0	1.2	0.4	0.3	-0.6	0.1	-0.3	-1.1	-0.4	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.3	0.6	0.1	0.5	0.4	0.8	0.7	0.8	0.2	-0.9	-0.5	-0.4	0.0
Multivitamins +/- minerals	0.3	0.4	1.9	-1.4	-0.4	-0.4	-0.7	0.5	-0.5	-0.5	-0.9	-0.3	0.7	-0.1	0.3	-0.0
Sitting height	0.3	1.8	4.8	-1.9	-0.4	-0.2	0.3	0.3	0.1	-0.2	-0.6	-2.1	-2.2	-2.0	-2.1	-1.4
Alcohol usually taken with meals	0.3	0.5	1.5	0.6	0.3	-0.5	-1.1	-0.2	-0.2	0.2	0.2	1.2	1.2	0.5	1.1	0.4
Diabetes (self-reported)	0.3	0.5	2.7	-1.6	0.7	-0.1	0.7	1.4	0.4	0.3	-0.6	-0.2	-0.3	-0.5	-0.1	-0.1
Medication: Simvastatin	0.3	0.4	1.2	-0.7	-0.6	-0.3	-0.3	0.1	-1.0	-0.9	-0.9	0.0	1.1	-0.2	0.4	-0.3
Time employed in main current job	0.3	0.4	1.9	-0.4	-0.3	-1.4	-1.1	0.6	-0.3	-0.1	-0.5	0.1	0.4	0.2	0.3	-0.3
Prospective memory result	0.3	0.4	1.9	-0.4	0.1	0.2	1.4	1.3	0.5	0.5	0.1	0.2	0.3	0.2	0.4	0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.6	-0.5	0.1	0.1	0.1	0.4	0.6	0.5	0.1	-0.6	-1.3	-1.0	-0.8	-0.4
Gout (self-reported)	0.3	0.4	1.9	-1.4	-0.9	-0.0	-0.5	0.4	-0.4	-0.2	-0.5	-0.3	-0.1	-0.9	-0.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.5	-0.3	-0.1	-0.3	-0.4	1.2	-0.5	-0.5	-1.0	0.4	0.8	-0.6	0.6	-0.0
Medication for pain relief, constipation, heartburn	0.3	0.4	1.4	0.2	-0.9	-0.4	-0.7	-0.6	-0.4	-0.4	-0.2	-0.4	-0.7	-1.2	-0.9	-0.7
Migraine (self-reported)	0.3	0.4	0.9	0.4	0.3	0.9	-0.6	0.3	0.5	0.5	0.6	0.9	0.6	0.1	0.6	0.9
Medication: Ibuprofen	0.3	0.3	1.8	0.5	-0.4	0.1	-0.3	-1.3	0.2	0.0	0.8	-0.4	-0.7	0.3	-0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.8	0.4	-0.5	-1.4	-0.7	-0.9	-0.5	-0.6	-0.3	-0.3	-0.1	-0.4	-0.2	-0.5
Illnesses of siblings: Diabetes	0.3	0.4	1.3	0.3	1.1	0.2	0.3	0.4	0.6	0.8	0.1	0.2	-0.8	-1.0	-0.5	0.1
Average weekly red wine intake	0.3	0.5	1.0	0.7	0.9	0.7	-0.0	0.1	0.2	0.1	0.4	1.0	1.0	1.0	0.9	0.9
Diabetes diagnosed by doctor	0.3	0.6	2.5	-1.6	0.6	0.1	0.4	1.4	0.4	0.2	-0.7	-0.5	-0.7	-0.9	-0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.3	-1.2	0.6	0.4	1.0	0.9	0.2	-0.0	-0.4	-0.3	-0.5	-0.6	-0.4	-0.1
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	-0.1	0.3	-0.2	-0.9	0.4	-0.7	-0.5	-0.9	0.6	1.0	0.3	0.6	-0.1
High cholesterol (Self-reported)	0.3	0.6	2.0	-1.4	-0.4	-0.0	-0.1	0.6	-0.7	-0.9	-1.1	-0.4	1.1	0.9	0.7	-0.3
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.7	-1.3	-0.1	-0.2	0.3	0.7	-0.1	-0.1	-0.4	-0.6	-0.5	-0.5	-0.7	-0.3
Basal cell carcinoma (self-reported)	0.3	0.4	2.2	1.5	0.3	-0.7	-0.7	-0.3	0.4	0.5	0.6	0.6	-0.5	-0.5	-0.4	-0.2
HbA1C	0.2	0.2	0.8	0.3	-0.1	0.5	-0.5	0.5	-0.1	-0.2	-0.1	0.5	0.9	0.4	0.6	0.3
Primary Biliary Cirrhosis	0.2	0.2	0.7	0.8	0.6	0.0	-0.0	-0.8	-0.2	-0.2	0.0	0.8	0.5	0.1	0.7	0.4
Blood White Count	0.2	1.8	8.4	-2.9	-0.1	0.9	1.1	2.8	0.6	0.7	-0.7	-1.0	-1.1	-1.3	-0.8	0.0
Height	0.2	3.1	8.6	0.8	1.8	1.6	1.9	0.6	2.9	2.9	2.6	0.0	-2.1	-1.1	-0.6	0.7
Chronotype (morning person)	0.2	0.4	1.8	0.2	-0.3	-1.3	-0.0	-0.8	-0.4	-0.3	0.4	0.3	0.7	0.9	0.6	-0.3
Angina	0.2	0.3	0.8	-0.4	-0.8	-0.1	-0.5	-0.8	-0.6	-0.9	-0.6	-0.5	0.2	0.1	-0.1	-0.2
Hand grip strength (right)	0.2	0.4	1.1	-0.4	0.2	1.0	0.1	1.1	0.5	0.5	0.0	0.4	0.8	0.6	0.9	0.8
Age when periods started (menarche)	0.2	0.4	1.7	0.4	0.4	1.3	0.9	0.2	0.6	0.6	0.7	-0.1	-0.2	0.8	0.1	0.5
Qualifications: CSEs or equivalent	0.2	0.3	0.8	-0.9	-0.3	0.7	0.8	0.3	0.3	0.1	0.3	-0.9	-0.8	-0.3	-0.6	-0.2
Number of incorrect matches in round	0.2	0.3	1.3	1.1	0.8	0.2	0.3	-0.7	0.1	0.4	0.6	0.6	-0.0	-0.0	0.1	0.2
Past tobacco smoking	0.2	0.3	0.8	-0.8	0.2	-0.4	0.2	0.9	0.4	0.6	0.1	-0.4	-0.8	-0.6	-0.5	-0.4
Pain all over the body in last month	0.2	0.2	0.4	0.3	0.7	0.6	-0.6	0.5	0.3	0.4	0.2	0.3	-0.2	-0.6	-0.1	0.4
Alcohol intake versus 10 years previously	0.2	0.3	0.8	0.9	-0.4	-0.6	-0.8	-0.7	-0.5	-0.5	0.2	0.4	0.5	0.5	0.5	-0.1
Falls in the last year	0.2	0.3	0.8	0.9	0.4	0.2	-0.0	-0.6	0.3	0.2	0.6	-0.1	-0.9	-0.7	-0.7	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.8	0.5	-0.2	-0.1	-0.1	-0.9	0.4	0.4	0.8	-0.3	-0.8	0.0	-0.4	-0.3
Standing height	0.2	1.5	3.8	0.3	1.0	1.2	1.2	0.2	1.8	1.8	1.8	-0.3	-1.9	-1.0	-1.0	0.4
Glaucoma (self-reported)	0.2	0.3	0.9	-0.7	-0.1	-0.1	-0.9	0.6	-0.6	-0.5	-0.8	-0.0	0.3	-0.2	-0.1	-0.4
Neck or shoulder pain in last month	0.2	0.3	1.3	-0.0	0.2	0.1	0.1	-0.3	0.6	0.2	0.8	-0.9	-1.2	0.3	-0.7	-0.4
Angina (self-reported)	0.2	0.2	0.7	-0.5	-0.7	0.1	-0.6	-0.6	-0.6	-0.9	-0.6	-0.4	0.4	0.1	0.1	-0.1
Medication: Allopurinol	0.2	0.3	2.1	-1.5	-0.4	0.3	-0.3	0.9	-0.2	-0.4	-0.6	-0.4	0.2	-0.1	-0.0	-0.2
Comparative height size at age 10	0.2	1.1	3.1	-0.1	1.3	1.8	0.9	0.8	0.6	0.9	0.8	1.1	1.1	0.5	1.2	1.4
Chest pain or discomfort	0.2	0.2	0.6	-0.7	-0.5	0.6	-0.2	0.1	-0.1	-0.5	-0.4	-0.5	-0.4	-0.8	-0.6	-0.1
Had major operations	0.2	0.3	1.3	1.2	0.0	0.7	-0.0	-0.1	0.3	-0.1	0.2	0.9	0.5	0.1	0.4	0.6
Smoking status: Previous	0.2	0.3	1.9	1.4	0.5	0.6	0.2	-0.9	0.2	0.0	0.4	0.6	0.1	0.2	0.2	0.6
Ever had bowel cancer screening	0.2	0.2	0.7	-0.4	0.5	-0.1	0.7	0.8	0.3	0.5	0.0	0.3	-0.1	-0.5	-0.1	0.1
Asthma (self-reported)	0.2	0.3	1.5	1.1	-0.7	0.2	0.3	-1.2	0.1	-0.2	0.6	0.1	-0.3	-0.2	-0.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	2.0	-1.0	0.1	0.1	0.4	1.4	-0.3	-0.4	-0.9	-0.5	-0.0	-0.7	-0.5	-0.2
Ever smoked	0.2	0.3	1.3	0.0	-0.4	0.5	-0.6	-0.2	-0.4	-0.7	-0.4	0.2	1.1	0.9	0.8	0.4
Average weekly beer plus cider intake	0.2	0.3	1.0	-0.9	-0.4	-0.9	-0.0	0.4	-0.0	-0.4	-0.6	-0.3	-0.6	-1.0	-0.4	-0.4
Ever depressed for a whole week	0.2	0.3	0.8	-0.6	0.0	-0.9	-0.9	0.2	0.0	0.1	-0.2	-0.6	-0.6	-0.4	-0.5	-0.6
Unable to work because of sickness or disability	0.2	0.2	0.8	0.9	0.2	0.0	0.3	0.3	0.5	0.5	0.8	0.6	-0.2	-0.2	0.2	0.2
Pain experienced in last month	0.2	0.3	1.0	-0.9	-1.0	0.1	-0.0	0.5	-0.6	-0.3	-1.0	0.0	0.8	-0.4	0.4	0.1
Supplements: Calcium	0.2	0.3	0.9	0.4	-0.5	-0.9	-0.8	-0.6	-0.6	-0.6	-0.2	-0.1	0.2	-0.3	-0.2	-0.3
Heel T-Score	0.1	0.6	2.7	1.3	0.3	0.2	0.0	-1.6	-0.4	-0.5	0.4	0.4	0.6	1.1	0.4	0.3
Tanning	0.1	1.2	3.4	0.6	1.0	0.6	1.8	0.3	1.6	1.8	1.6	0.5	-0.8	-0.3	0.2	0.8
Vitamin and mineral supplements	0.1	0.2	0.4	0.5	-0.4	-0.2	0.3	-0.0	-0.4	-0.4	-0.2	0.6	0.6	0.7	0.5	-0.2
Had menopause	0.1	0.2	0.6	0.5	0.1	0.1	-0.0	0.4	0.6	0.5	0.2	0.1	-0.8	-0.6	-0.5	0.1
Asthma	0.1	0.2	1.1	1.0	-0.5	0.3	0.3	-1.0	0.1	-0.1	0.7	0.2	-0.1	0.2	0.1	0.1
Medication: Paracetamol	0.1	0.2	1.6	1.3	0.8	-0.3	-0.1	-0.0	0.4	0.3	0.5	0.2	-0.3	0.2	-0.0	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.8	-0.5	0.3	0.6	0.4	0.9	0.2	0.2	-0.3	0.2	0.1	0.2	0.2	0.3
Medication: Seretide 50 evohaler	0.1	0.1	1.2	0.3	0.1	-0.0	1.1	0.1	-0.0	-0.0	-0.1	0.4	0.4	-0.0	0.5	0.2
Alcohol intake frequency.	0.1	0.3	1.1	1.0	-0.1	-0.1	-0.3	-0.9	-0.1	-0.2	0.4	-0.3	-0.9	-0.9	-0.7	-0.5
Commuting to job workplace: Walk	0.1	0.1	0.9	1.0	-0.3	0.3	-0.4	-0.6	-0.3	-0.2	0.0	0.2	0.2	0.1	-0.0	0.0
Ever taken oral contraceptive pill	0.1	0.2	0.4	-0.6	0.2	0.2	-0.1	0.5	-0.4	-0.5	-0.5	-0.2	0.6	0.4	0.4	-0.0
Medication: Atorvastatin	0.1	0.1	0.4	-0.1	-0.1	-0.6	0.2	-0.5	-0.2	-0.3	-0.3	-0.6	-0.3	-0.3	-0.4	-0.5
Alcohol drinker status: Never	0.1	0.1	0.5	0.7	0.3	-0.6	-0.4	-0.6	0.3	-0.1	0.2	-0.1	-0.4	0.2	-0.2	-0.2
Risk taking	0.1	0.2	0.4	0.5	-0.2	0.3	0.1	-0.6	0.0	-0.2	0.2	-0.6	-0.4	0.7	-0.3	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.2	0.1	0.2	0.4	-0.1	0.4	-0.0	0.2	-0.1	0.4	0.3	-0.3	0.2	0.3
Waist Hip Ratio (WHR)	0.0	0.2	0.6	0.2	0.5	0.8	0.4	-0.8	-0.4	-0.3	-0.3	-0.5	-0.2	-0.5	-0.2	-0.3
Hair Pigment	0.0	0.3	0.5	-0.2	-0.7	0.2	0.2	-0.5	-0.6	-0.7	-0.7	-0.7	-0.3	-0.5	-0.4	-0.7

Hub : Genes

VCL

Models

Trait associations