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chr10:125,739,009-127,174,440

Best TWAS P=2.71e-09 · Best GWAS P=6.92e-10 conditioned to 9.3e-10

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	The Cancer Genome Atlas	Rectum Adenocarcinoma	METTL10	0.25	0.11	lasso	4	0.23	3.8e-06	-5.2	-5.9	2.7e-09	0.01	0.02	0.90	TRUE
9	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	METTL10	0.11	0.08	blup	43	0.12	4.8e-06	-5.0	-5.5	3.8e-08	-0.04	0.01	0.98	FALSE
3	GTEx	Lung	METTL10	0.11	0.06	enet	6	0.05	1.7e-04	-5.1	-5.3	1.0e-07	-0.02	0.50	0.46	FALSE
11	The Cancer Genome Atlas	Prostate Adenocarcinoma	METTL10	0.10	0.17	blup	43	0.18	1.9e-18	-5.2	-5.3	1.2e-07	-0.04	0.01	0.99	FALSE
6	The Cancer Genome Atlas	Breast Invasive Carcinoma	METTL10	0.06	0.13	lasso	7	0.13	1.1e-25	-5.2	-5.3	1.5e-07	-0.04	0.01	0.99	FALSE
5	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	METTL10	0.09	0.08	blup	43	0.11	1.2e-09	-5.2	-5.2	1.7e-07	-0.02	0.01	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	METTL10	0.20	0.26	lasso	9	0.26	4.5e-31	-5.1	-5.2	1.8e-07	-0.04	0.36	0.64	FALSE
8	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	METTL10	0.10	0.16	lasso	7	0.17	1.0e-18	-5.2	-5.2	1.9e-07	-0.04	0.01	0.99	FALSE
4	GTEx	Thyroid	METTL10	0.19	0.09	enet	33	0.10	3.0e-08	-5.1	-5.2	2.1e-07	-0.02	0.43	0.57	FALSE
7	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	METTL10	0.10	0.14	blup	43	0.14	7.4e-16	-5.2	-5.2	2.2e-07	-0.02	0.01	0.99	FALSE
10	The Cancer Genome Atlas	Lung Adenocarcinoma	METTL10	0.11	0.19	lasso	6	0.19	7.3e-22	-5.1	-5.2	2.2e-07	-0.03	0.01	0.99	FALSE
2	GTEx	Brain Caudate basal ganglia	METTL10	0.33	0.16	lasso	3	0.18	7.6e-06	4.0	-5.1	2.9e-07	-0.03	0.38	0.33	FALSE