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chr10:130,566,749-132,263,732

Best TWAS P=6.12e-09 · Best GWAS P=4.82e-08 conditioned to 0.0995

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
8	GTEx	Colon Transverse	MGMT	0.47	0.24	enet	58	0.35	1.6e-17	-5.2	5.8	6.1e-09	-0.75	0.01	0.98	TRUE
14	GTEx	Ovary	MGMT	0.52	0.09	enet	59	0.12	8.6e-04	-4.6	5.8	6.7e-09	-0.65	0.03	0.94	FALSE
9	GTEx	Esophagus Mucosa	MGMT	0.41	0.33	enet	37	0.38	2.3e-26	-5.2	5.7	9.1e-09	-0.82	0.01	0.99	FALSE
16	GTEx	Skin Sun Exposed Lower leg	MGMT	0.45	0.30	enet	42	0.46	1.6e-41	-4.6	5.7	9.3e-09	-0.85	0.02	0.98	FALSE
7	GTEx	Cells Transformed fibroblasts	MGMT	0.45	0.30	enet	31	0.42	4.8e-34	-4.6	5.6	2.1e-08	-0.85	0.03	0.97	FALSE
23	YFS	Blood	MGMT	0.50	0.40	enet	94	0.55	1.6e-218	-5.2	5.6	2.7e-08	-0.81	0.01	0.99	FALSE
20	GTEx	Thyroid	MGMT	0.44	0.35	lasso	11	0.43	1.9e-35	-5.4	5.5	3.0e-08	-0.92	0.00	1.00	FALSE
3	GTEx	Adrenal Gland	MGMT	0.39	0.25	lasso	6	0.30	1.5e-11	-5.4	5.5	3.7e-08	-0.95	0.00	1.00	FALSE
15	GTEx	Prostate	MGMT	0.25	0.13	lasso	4	0.20	9.4e-06	-5.4	5.5	3.9e-08	-0.90	0.02	0.96	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	MGMT	0.41	0.38	enet	46	0.48	3.6e-69	-5.2	5.5	3.9e-08	-0.87	0.00	0.99	FALSE
18	GTEx	Stomach	MGMT	0.33	0.20	enet	9	0.25	2.3e-12	-4.6	5.5	4.1e-08	-0.93	0.00	0.99	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MGMT	0.26	0.32	lasso	10	0.37	2.9e-43	-5.5	5.5	4.6e-08	-0.94	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MGMT	0.10	0.09	enet	23	0.10	1.9e-11	-4.6	5.4	6.3e-08	-0.74	0.08	0.91	FALSE
13	GTEx	Nerve Tibial	MGMT	0.50	0.23	enet	46	0.42	6.9e-32	-4.6	5.4	6.4e-08	-0.71	0.12	0.87	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MGMT	0.29	0.27	lasso	14	0.31	6.0e-38	-5.4	5.4	6.6e-08	-0.89	0.00	1.00	FALSE
4	GTEx	Brain Cerebellar Hemisphere	MGMT	0.53	0.15	lasso	8	0.19	1.3e-05	-5.4	5.4	7.2e-08	-0.93	0.01	0.98	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	MGMT	0.16	0.17	enet	22	0.21	2.4e-41	-5.2	5.4	8.8e-08	-0.89	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MGMT	0.25	0.05	blup	234	0.12	1.9e-06	-5.2	5.3	1.0e-07	-0.62	0.01	0.97	FALSE
2	GTEx	Adipose Subcutaneous	MGMT	0.39	0.27	enet	30	0.48	1.2e-44	-4.6	5.3	1.1e-07	-0.83	0.02	0.98	FALSE
5	GTEx	Breast Mammary Tissue	MGMT	0.60	0.21	enet	13	0.33	1.6e-17	-5.2	5.3	1.1e-07	-0.88	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MGMT	0.40	0.24	enet	29	0.37	1.9e-22	-5.5	5.3	1.1e-07	-0.86	0.00	1.00	FALSE
10	GTEx	Heart Atrial Appendage	MGMT	0.41	0.17	enet	33	0.22	4.6e-10	-5.2	5.3	1.2e-07	-0.87	0.00	0.99	FALSE
12	GTEx	Liver	MGMT	0.46	0.39	lasso	4	0.42	8.2e-13	-5.2	5.3	1.2e-07	-0.84	0.01	0.99	FALSE
6	GTEx	Breast Mammary Tissue (Female)	MGMT	0.46	0.31	lasso	4	0.33	1.1e-10	-5.2	5.2	1.8e-07	-0.82	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MGMT	0.18	0.03	blup	239	0.12	2.3e-06	-5.2	5.2	1.8e-07	-0.75	0.02	0.98	FALSE
21	NTR	Blood	MGMT	0.08	0.07	lasso	8	0.08	3.7e-24	-5.2	5.2	1.9e-07	-0.86	0.01	0.99	FALSE
17	GTEx	Small Intestine Terminal Ileum	MGMT	0.31	0.14	enet	11	0.21	1.6e-05	-4.6	5.2	2.1e-07	-0.87	0.02	0.95	FALSE
31	The Cancer Genome Atlas	Stomach Adenocarcinoma	MGMT	0.15	0.08	lasso	4	0.10	7.5e-08	-5.2	5.2	2.1e-07	-0.85	0.01	0.99	FALSE
19	GTEx	Testis	MGMT	0.49	0.34	lasso	5	0.35	2.8e-16	-5.2	5.2	2.5e-07	-0.88	0.01	0.99	FALSE
11	GTEx	Heart Left Ventricle	MGMT	0.27	0.20	lasso	7	0.22	6.3e-12	-5.2	5.1	2.7e-07	-0.90	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	MGMT	0.39	0.31	enet	60	0.35	1.8e-37	-5.2	5.1	2.7e-07	-0.75	0.01	0.99	FALSE