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chr11:42,881,882-44,607,471

Best TWAS P=8.17e-21 · Best GWAS P=6.06e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
69	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HSD17B12	0.18	0.22	lasso	2	0.20	2.2e-10	8.9	-9.4	8.2e-21	-0.99	0.00	1.00	TRUE
12	GTEx	Artery Tibial	RP11-613D13.5	0.17	0.18	lasso	6	0.18	2.4e-14	8.9	-9.2	2.7e-20	-0.98	0.00	1.00	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	HSD17B12	0.51	0.35	lasso	7	0.37	3.1e-14	8.9	-9.2	3.6e-20	-0.96	0.01	0.99	FALSE
52	GTEx	Skin Sun Exposed Lower leg	RP11-613D13.5	0.17	0.22	lasso	3	0.21	2.2e-17	8.9	-9.0	2.5e-19	-1.00	0.00	1.00	FALSE
58	GTEx	Thyroid	RP11-613D13.5	0.24	0.18	lasso	2	0.15	7.3e-12	8.9	-9.0	2.7e-19	-1.00	0.00	1.00	FALSE
37	GTEx	Heart Left Ventricle	HSD17B12	0.25	0.28	lasso	4	0.25	8.2e-14	8.9	-9.0	2.8e-19	-1.00	0.01	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	HSD17B12	0.28	0.25	enet	17	0.21	2.6e-11	8.9	-8.9	4.5e-19	-0.93	0.02	0.98	FALSE
46	GTEx	Pancreas	HSD17B12	0.43	0.40	lasso	2	0.40	7.6e-18	8.9	-8.9	4.6e-19	-0.99	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD17B12	0.10	0.20	lasso	4	0.20	7.5e-39	8.9	-8.9	4.9e-19	-1.00	0.00	1.00	FALSE
57	GTEx	Thyroid	HSD17B12	0.52	0.59	lasso	4	0.59	1.1e-55	8.9	-8.9	5.0e-19	-1.00	0.00	1.00	FALSE
85	The Cancer Genome Atlas	Soft Tissue Sarcoma	HSD17B12	0.13	0.20	lasso	3	0.18	3.9e-11	8.9	-8.9	5.2e-19	-1.00	0.00	1.00	FALSE
51	GTEx	Skin Sun Exposed Lower leg	HSD17B12	0.46	0.60	lasso	7	0.61	9.2e-63	8.9	-8.9	5.4e-19	-0.99	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSD17B12	0.32	0.48	lasso	4	0.47	1.5e-60	8.9	-8.9	5.9e-19	-1.00	0.00	1.00	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HSD17B12	0.28	0.30	lasso	4	0.29	8.1e-13	8.9	-8.9	5.9e-19	-1.00	0.01	0.99	FALSE
22	GTEx	Breast Mammary Tissue	HSD17B12	0.21	0.17	lasso	1	0.12	6.0e-07	8.9	-8.9	6.1e-19	-1.00	0.01	0.99	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	HSD17B12	0.45	0.59	lasso	1	0.59	1.9e-39	8.9	-8.9	6.1e-19	-1.00	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HSD17B12	0.22	0.25	lasso	1	0.24	9.8e-12	8.9	-8.9	6.1e-19	-1.00	0.00	1.00	FALSE
87	The Cancer Genome Atlas	Stomach Adenocarcinoma	HSD17B12	0.17	0.27	lasso	1	0.26	6.0e-19	8.9	-8.9	6.1e-19	-1.00	0.00	1.00	FALSE
90	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	HSD17B12	0.21	0.20	lasso	1	0.16	4.3e-05	8.9	-8.9	6.1e-19	-1.00	0.01	0.98	FALSE
41	GTEx	Lung	RP11-613D13.5	0.18	0.20	lasso	2	0.17	6.0e-13	8.9	-8.9	6.5e-19	-1.00	0.00	1.00	FALSE
55	GTEx	Stomach	RP11-613D13.5	0.18	0.21	lasso	3	0.21	1.6e-10	8.9	-8.9	6.6e-19	-1.00	0.01	0.99	FALSE
19	GTEx	Brain Hippocampus	HSD17B12	0.49	0.43	lasso	6	0.41	8.9e-11	8.9	-8.9	6.7e-19	-1.00	0.02	0.98	FALSE
7	GTEx	Adrenal Gland	HSD17B12	0.20	0.19	lasso	7	0.18	5.2e-07	8.9	-8.9	6.9e-19	-1.00	0.02	0.98	FALSE
54	GTEx	Stomach	HSD17B12	0.37	0.51	lasso	2	0.51	9.5e-28	8.9	-8.9	6.9e-19	-1.00	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	RP11-613D13.5	0.10	0.11	lasso	2	0.10	8.1e-09	8.9	-8.9	8.2e-19	-1.00	0.01	0.99	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	HSD17B12	0.60	0.66	lasso	2	0.65	4.5e-84	8.9	-8.8	8.4e-19	-1.00	0.00	1.00	FALSE
62	GTEx	Whole Blood	HSD17B12	0.29	0.36	lasso	3	0.36	4.5e-34	8.9	-8.8	8.8e-19	-1.00	0.00	1.00	FALSE
79	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HSD17B12	0.20	0.26	lasso	2	0.26	1.3e-29	8.9	-8.8	9.5e-19	-1.00	0.00	1.00	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	HSD17B12	0.36	0.52	lasso	6	0.52	3.8e-63	8.9	-8.8	9.6e-19	-1.00	0.00	1.00	FALSE
73	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD17B12	0.19	0.27	lasso	3	0.27	9.8e-31	8.9	-8.8	9.7e-19	-0.99	0.01	0.99	FALSE
31	GTEx	Esophagus Mucosa	HSD17B12	0.54	0.58	lasso	12	0.58	1.3e-47	8.9	-8.8	1.0e-18	-0.99	0.01	0.99	FALSE
45	GTEx	Ovary	HSD17B12	0.45	0.36	lasso	17	0.33	5.4e-09	8.9	-8.8	1.2e-18	-0.98	0.03	0.97	FALSE
29	GTEx	Colon Transverse	RP11-613D13.5	0.21	0.24	lasso	3	0.23	3.4e-11	8.9	-8.8	1.3e-18	-1.00	0.01	0.99	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HSD17B12	0.19	0.24	lasso	6	0.24	4.7e-14	8.9	-8.8	1.4e-18	-0.99	0.02	0.98	FALSE
18	GTEx	Brain Frontal Cortex BA9	HSD17B12	0.45	0.38	lasso	7	0.36	2.8e-10	8.9	-8.8	1.5e-18	-0.99	0.02	0.98	FALSE
9	GTEx	Artery Aorta	RP11-613D13.5	0.31	0.27	lasso	3	0.27	3.0e-15	8.9	-8.8	1.9e-18	-0.99	0.00	1.00	FALSE
25	GTEx	Cells Transformed fibroblasts	HSD17B12	0.60	0.69	lasso	10	0.69	2.0e-71	8.9	-8.8	1.9e-18	-0.99	0.01	0.99	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	RP11-613D13.5	0.17	0.12	enet	19	0.15	2.2e-08	8.4	-8.8	2.2e-18	-0.93	0.02	0.98	FALSE
28	GTEx	Colon Transverse	HSD17B12	0.48	0.49	lasso	4	0.50	1.3e-26	8.9	-8.7	2.4e-18	-0.99	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	HSD17B12	0.31	0.35	lasso	5	0.37	2.8e-31	8.4	-8.7	2.6e-18	-0.99	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HSD17B12	0.44	0.51	lasso	11	0.53	6.0e-76	8.9	-8.7	2.8e-18	-0.99	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Glioblastoma Multiforme	HSD17B12	0.43	0.43	lasso	6	0.45	3.4e-15	8.5	-8.7	2.8e-18	-0.98	0.02	0.98	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HSD17B12	0.35	0.52	lasso	4	0.54	4.7e-71	8.5	-8.7	2.9e-18	-0.98	0.03	0.97	FALSE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HSD17B12	0.19	0.27	enet	10	0.27	6.1e-23	8.9	-8.7	3.0e-18	-0.97	0.01	0.99	FALSE
11	GTEx	Artery Tibial	HSD17B12	0.47	0.54	lasso	5	0.59	8.9e-57	8.9	-8.7	3.1e-18	-0.98	0.00	1.00	FALSE
78	The Cancer Genome Atlas	Lung Adenocarcinoma	HSD17B12	0.22	0.33	enet	18	0.33	1.1e-39	8.9	-8.7	4.2e-18	-0.98	0.01	0.99	FALSE
86	The Cancer Genome Atlas	Skin Cutaneous Melanoma	HSD17B12	0.15	0.08	enet	17	0.08	3.0e-03	8.5	-8.7	4.7e-18	-0.93	0.03	0.75	FALSE
24	GTEx	Breast Mammary Tissue (Male)	HSD17B12	0.48	0.34	lasso	14	0.34	1.1e-08	8.4	-8.7	5.1e-18	-0.98	0.03	0.96	FALSE
82	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HSD17B12	0.21	0.24	lasso	8	0.23	1.9e-09	8.9	-8.7	5.1e-18	-0.98	0.01	0.99	FALSE
34	GTEx	Esophagus Muscularis	RP11-613D13.5	0.21	0.20	lasso	2	0.19	9.6e-12	8.9	-8.6	6.0e-18	-0.96	0.01	0.99	FALSE
27	GTEx	Colon Sigmoid	HSD17B12	0.44	0.38	lasso	8	0.37	6.7e-14	8.9	-8.6	6.2e-18	-0.97	0.02	0.98	FALSE
33	GTEx	Esophagus Muscularis	HSD17B12	0.57	0.56	lasso	8	0.58	1.1e-42	8.9	-8.6	7.0e-18	-0.99	0.01	0.99	FALSE
16	GTEx	Brain Cerebellum	HSD17B12	0.52	0.39	lasso	16	0.36	2.4e-11	8.5	-8.6	7.3e-18	-0.95	0.03	0.97	FALSE
10	GTEx	Artery Coronary	HSD17B12	0.61	0.41	lasso	19	0.43	4.5e-16	8.9	-8.6	8.3e-18	-0.94	0.02	0.98	FALSE
32	GTEx	Esophagus Mucosa	RP11-613D13.5	0.17	0.19	lasso	6	0.18	2.5e-12	8.5	-8.6	9.3e-18	-0.95	0.06	0.94	FALSE
56	GTEx	Testis	HSD17B12	0.67	0.58	lasso	10	0.60	8.5e-33	8.5	-8.6	1.2e-17	-0.95	0.06	0.94	FALSE
8	GTEx	Artery Aorta	HSD17B12	0.61	0.55	lasso	9	0.59	3.4e-39	8.9	-8.5	1.4e-17	-0.99	0.01	0.99	FALSE
80	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD17B12	0.18	0.23	lasso	4	0.23	6.6e-16	8.3	-8.5	1.5e-17	-0.98	0.02	0.98	FALSE
70	The Cancer Genome Atlas	Colon Adenocarcinoma	HSD17B12	0.33	0.36	enet	17	0.39	7.5e-24	8.4	-8.5	2.3e-17	-0.96	0.03	0.97	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-613D13.5	0.18	0.01	lasso	3	0.05	8.9e-04	8.9	-8.5	2.6e-17	-0.81	0.01	0.99	FALSE
44	GTEx	Nerve Tibial	RP11-613D13.5	0.14	0.19	lasso	2	0.18	1.1e-12	8.5	-8.5	2.6e-17	-0.95	0.06	0.94	FALSE
26	GTEx	Cells Transformed fibroblasts	RP11-613D13.5	0.34	0.42	lasso	9	0.42	4.5e-34	8.4	-8.4	2.8e-17	-0.97	0.05	0.95	FALSE
17	GTEx	Brain Cortex	HSD17B12	0.52	0.37	lasso	9	0.40	5.4e-12	8.5	-8.4	3.3e-17	-0.96	0.03	0.97	FALSE
35	GTEx	Heart Atrial Appendage	HSD17B12	0.52	0.46	lasso	6	0.44	1.2e-21	8.9	-8.3	1.1e-16	-0.99	0.01	0.99	FALSE
66	YFS	Blood	HSD17B12	0.37	0.44	enet	31	0.47	1.2e-176	8.4	-8.2	1.6e-16	-0.93	0.10	0.90	FALSE
42	GTEx	Muscle Skeletal	HSD17B12	0.35	0.38	enet	24	0.37	3.4e-38	8.9	-8.2	1.8e-16	-0.97	0.00	1.00	FALSE
64	METSIM	Adipose	HSD17B12	0.19	0.29	bslmm	660	0.29	4.7e-43	8.5	-8.2	2.2e-16	-0.94	0.09	0.91	FALSE
39	GTEx	Liver	RP11-613D13.5	0.30	0.24	lasso	3	0.23	4.6e-07	8.7	-8.2	2.4e-16	-0.78	0.02	0.98	FALSE
84	The Cancer Genome Atlas	Rectum Adenocarcinoma	HSD17B12	0.39	0.25	lasso	4	0.26	7.2e-07	8.2	-8.2	2.9e-16	-0.94	0.06	0.93	FALSE
71	The Cancer Genome Atlas	Esophageal Carcinoma	HSD17B12	0.27	0.31	enet	17	0.31	1.2e-10	8.3	-8.2	3.4e-16	-0.94	0.04	0.96	FALSE
38	GTEx	Liver	HSD17B12	0.46	0.38	enet	24	0.28	1.3e-08	8.3	-8.2	3.5e-16	-0.95	0.03	0.97	FALSE
40	GTEx	Lung	HSD17B12	0.54	0.59	enet	32	0.61	8.3e-59	8.9	-8.1	4.3e-16	-0.96	0.00	1.00	FALSE
61	GTEx	Vagina	HSD17B12	0.55	0.31	lasso	19	0.34	1.3e-08	8.9	-8.1	5.6e-16	-0.88	0.03	0.97	FALSE
13	GTEx	Brain Caudate basal ganglia	HSD17B12	0.68	0.43	lasso	18	0.49	6.0e-16	8.5	-8.0	1.1e-15	-0.93	0.05	0.95	FALSE
47	GTEx	Prostate	HSD17B12	0.65	0.51	enet	34	0.53	8.8e-16	8.5	-8.0	1.2e-15	-0.93	0.02	0.98	FALSE
21	GTEx	Brain Putamen basal ganglia	HSD17B12	0.51	0.30	enet	28	0.33	1.3e-08	8.5	-8.0	1.3e-15	-0.87	0.04	0.95	FALSE
23	GTEx	Breast Mammary Tissue	RP11-613D13.5	0.18	0.11	lasso	5	0.15	6.3e-08	8.9	-8.0	1.4e-15	-0.88	0.02	0.98	FALSE
60	GTEx	Uterus	RP11-613D13.5	0.61	0.22	lasso	12	0.26	3.9e-06	6.6	-7.9	2.5e-15	-0.80	0.02	0.95	FALSE
59	GTEx	Uterus	HSD17B12	0.60	0.48	enet	20	0.52	2.1e-12	8.2	-7.9	2.9e-15	-0.93	0.04	0.96	FALSE
15	GTEx	Brain Cerebellar Hemisphere	HSD17B12	0.50	0.41	enet	33	0.29	3.0e-08	8.5	-7.9	3.6e-15	-0.89	0.03	0.97	FALSE
43	GTEx	Nerve Tibial	HSD17B12	0.58	0.52	enet	56	0.56	3.5e-47	8.5	-7.8	5.7e-15	-0.93	0.06	0.94	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	HSD17B12	0.41	0.27	lasso	16	0.20	4.5e-06	8.5	-7.7	1.0e-14	-0.90	0.05	0.95	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	HSD17B12	0.45	0.37	enet	72	0.47	1.1e-68	8.9	-7.3	3.2e-13	-0.88	0.00	1.00	FALSE
53	GTEx	Spleen	HSD17B12	0.55	0.48	enet	48	0.47	9.6e-14	8.9	-7.2	4.5e-13	-0.91	0.01	0.99	FALSE
36	GTEx	Heart Atrial Appendage	RP11-613D13.5	0.18	0.02	enet	11	0.07	5.3e-04	8.9	-7.0	1.9e-12	-0.84	0.02	0.97	FALSE
48	GTEx	Prostate	RP11-613D13.5	0.29	0.07	enet	27	0.16	8.2e-05	8.5	-6.8	9.4e-12	-0.77	0.02	0.94	FALSE
5	GTEx	Adipose Visceral Omentum	SEC14L1P1	0.12	0.00	enet	6	0.00	3.5e-01	4.2	6.8	1.2e-11	0.41	0.06	0.39	FALSE
88	The Cancer Genome Atlas	Testicular Germ Cell Tumors	HSD17B12	0.34	0.26	blup	115	0.26	1.6e-09	8.9	-6.4	1.8e-10	-0.82	0.02	0.98	FALSE
14	GTEx	Brain Caudate basal ganglia	RP11-613D13.5	0.32	0.14	enet	24	0.13	1.6e-04	8.5	-6.2	6.9e-10	-0.84	0.03	0.94	FALSE
63	GTEx	Whole Blood	RP11-613D13.5	0.06	0.01	lasso	4	0.00	1.2e-01	-5.0	-6.0	2.2e-09	-0.59	0.05	0.44	FALSE