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chr11:46,578,400-48,485,877

Best TWAS P=9.71e-13 · Best GWAS P=2.25e-15 conditioned to 0.173

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	5.7	-5.2	2.3e-07	0.50	1.00	0.00	FALSE
2	GTEx	Artery Aorta	MADD	0.09	0.03	enet	22	0.04	1.9e-03	-7.9	6.8	7.8e-12	-0.72	0.01	0.92	FALSE
3	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	5.5	-5.5	3.3e-08	0.45	0.59	0.05	FALSE
4	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	-5.8	-5.6	1.7e-08	0.70	0.05	0.15	FALSE
5	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	-6.1	5.8	7.7e-09	-0.63	0.97	0.03	FALSE
6	GTEx	Cells Transformed fibroblasts	MADD	0.19	0.00	enet	17	0.09	3.3e-07	-2.4	5.1	2.8e-07	-0.16	0.53	0.04	FALSE
7	GTEx	Esophagus Mucosa	MADD	0.27	0.04	enet	18	0.12	4.1e-08	-3.4	6.0	1.4e-09	-0.54	0.15	0.46	FALSE
8	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	5.5	-5.5	3.3e-08	0.45	0.94	0.01	FALSE
9	GTEx	Esophagus Muscularis	MADD	0.13	0.07	enet	8	0.11	2.0e-07	-4.0	5.2	2.1e-07	-0.62	0.42	0.44	FALSE
10	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	5.5	-5.1	2.8e-07	0.54	0.96	0.02	FALSE
11	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	5.5	-5.5	3.3e-08	0.45	0.25	0.28	FALSE
12	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	5.5	-6.4	1.8e-10	0.73	0.10	0.82	FALSE
13	GTEx	Nerve Tibial	NR1H3	0.10	0.00	enet	24	0.08	4.7e-06	-1.1	-5.5	4.4e-08	0.33	0.07	0.18	FALSE
14	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	5.5	-5.3	1.5e-07	0.55	1.00	0.00	FALSE
15	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	-6.2	-6.3	2.3e-10	0.67	0.77	0.09	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	-6.2	7.1	9.7e-13	-0.78	0.58	0.42	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	MADD	0.33	0.16	enet	23	0.23	1.9e-29	-4.0	5.2	1.7e-07	-0.46	1.00	0.00	FALSE
18	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	-7.2	6.6	3.9e-11	-0.70	0.04	0.94	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	MADD	0.11	0.03	enet	14	0.06	1.4e-11	-4.0	5.6	1.9e-08	-0.46	0.10	0.58	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	5.5	-5.5	3.3e-08	0.45	0.82	0.04	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	-6.2	6.4	1.6e-10	-0.61	0.07	0.32	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	5.5	-5.8	7.3e-09	0.52	0.10	0.25	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MADD	0.16	0.05	blup	64	0.08	2.2e-09	2.6	5.2	2.3e-07	-0.31	0.24	0.08	TRUE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	MADD	0.15	0.04	enet	10	0.06	4.5e-07	-4.0	5.6	1.9e-08	-0.36	0.04	0.32	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	5.5	-5.7	1.2e-08	0.46	0.01	0.74	FALSE