TWAS
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Traits
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chr12:53,075,660-54,539,005
Best TWAS P=1.17e-08 · Best GWAS P=6.14e-09 conditioned to 0.0027
53M
53.2M
53.4M
53.6M
53.8M
54M
54.2M
54.4M
54.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
PRR13
0.07
0.04
blup
28
0.05
4.7e-06
4.4
-5.7
1.2e-08
0.60
0.32
0.34
TRUE
3
The Cancer Genome Atlas
Bladder Urothelial Carcinoma
PRR13
0.13
0.04
blup
28
0.07
3.3e-06
4.2
-5.6
2.1e-08
0.58
0.07
0.40
FALSE
2
GTEx
Esophagus Gastroesophageal Junction
PRR13
0.22
0.16
lasso
4
0.18
3.2e-07
4.4
-5.3
9.3e-08
0.29
0.25
0.15
FALSE
1
GTEx
Breast Mammary Tissue
SP1
0.12
0.13
lasso
5
0.08
9.5e-05
4.7
5.2
1.6e-07
-0.23
0.41
0.55
FALSE