Best TWAS P=1.06e-13 · Best GWAS P=1.27e-12 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RPS26 | 0.48 | 0.62 | lasso | 5 | 0.63 | 5.9e-99 | -5.3 | -5.3 | 1.1e-07 | 0.64 | 0.99 | 0.01 | FALSE |
2 | GTEx | Artery Tibial | RPS26 | 0.07 | 0.02 | enet | 5 | 0.01 | 3.5e-02 | -5.3 | -5.2 | 1.8e-07 | 0.65 | 0.16 | 0.43 | FALSE |
3 | GTEx | Breast Mammary Tissue | RPS26 | 0.29 | 0.05 | enet | 37 | 0.12 | 9.4e-07 | -5.3 | -6.8 | 9.7e-12 | 0.63 | 0.25 | 0.74 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | RPS26 | 0.20 | 0.11 | lasso | 3 | 0.10 | 6.6e-04 | -5.0 | -7.4 | 1.1e-13 | 0.84 | 0.01 | 0.83 | TRUE |
5 | GTEx | Esophagus Gastroesophageal Junction | SUOX | 0.20 | 0.16 | lasso | 5 | 0.19 | 2.7e-07 | -5.0 | 5.3 | 1.0e-07 | -0.66 | 0.27 | 0.70 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | WIBG | 0.16 | 0.02 | lasso | 5 | 0.04 | 1.9e-02 | 1.5 | 5.4 | 5.5e-08 | -0.35 | 0.03 | 0.39 | FALSE |
7 | GTEx | Heart Atrial Appendage | SUOX | 0.09 | 0.10 | enet | 8 | 0.09 | 1.1e-04 | -5.3 | 5.2 | 2.2e-07 | -0.68 | 0.10 | 0.73 | FALSE |
8 | GTEx | Muscle Skeletal | RAB5B | 0.29 | 0.32 | lasso | 4 | 0.33 | 1.3e-33 | -6.0 | 6.2 | 4.2e-10 | -0.66 | 0.63 | 0.37 | FALSE |
9 | GTEx | Muscle Skeletal | AC034102.1 | 0.28 | 0.31 | lasso | 4 | 0.31 | 2.3e-31 | -6.0 | 6.2 | 4.2e-10 | -0.66 | 0.62 | 0.38 | TRUE |
10 | GTEx | Prostate | SUOX | 0.22 | 0.04 | enet | 11 | 0.05 | 2.3e-02 | -5.0 | 6.4 | 1.4e-10 | -0.67 | 0.06 | 0.65 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | SUOX | 0.23 | 0.30 | lasso | 3 | 0.29 | 1.9e-24 | -5.0 | 5.2 | 1.9e-07 | -0.68 | 1.00 | 0.00 | FALSE |
12 | GTEx | Testis | SUOX | 0.27 | 0.18 | lasso | 14 | 0.18 | 1.4e-08 | -5.0 | 5.5 | 4.2e-08 | -0.67 | 0.38 | 0.61 | FALSE |
13 | GTEx | Thyroid | SUOX | 0.37 | 0.40 | lasso | 7 | 0.38 | 5.4e-31 | -5.0 | 5.2 | 2.0e-07 | -0.70 | 1.00 | 0.00 | TRUE |
14 | METSIM | Adipose | IKZF4 | 0.04 | 0.04 | enet | 3 | 0.04 | 1.0e-06 | -5.3 | -5.4 | 8.5e-08 | 0.61 | 0.97 | 0.02 | FALSE |
15 | METSIM | Adipose | RPS26 | 0.30 | 0.40 | lasso | 5 | 0.41 | 7.2e-66 | -5.4 | -5.4 | 7.6e-08 | 0.62 | 0.99 | 0.01 | FALSE |
16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RPS26 | 0.14 | 0.22 | lasso | 2 | 0.23 | 4.8e-19 | -5.4 | -5.4 | 6.8e-08 | 0.62 | 0.79 | 0.21 | FALSE |
17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPS26 | 0.30 | 0.44 | enet | 10 | 0.45 | 5.2e-104 | -5.3 | -5.6 | 2.0e-08 | 0.64 | 0.95 | 0.05 | FALSE |
18 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RPS26 | 0.23 | 0.40 | lasso | 2 | 0.39 | 1.5e-20 | -5.3 | -5.6 | 2.8e-08 | 0.64 | 0.66 | 0.34 | FALSE |
19 | The Cancer Genome Atlas | Colon Adenocarcinoma | RPS26 | 0.43 | 0.48 | lasso | 4 | 0.47 | 1.8e-30 | -5.3 | -5.7 | 1.4e-08 | 0.65 | 0.87 | 0.13 | FALSE |
20 | The Cancer Genome Atlas | Esophageal Carcinoma | RPS26 | 0.19 | 0.13 | lasso | 5 | 0.11 | 2.4e-04 | -5.3 | -5.5 | 3.4e-08 | 0.65 | 0.02 | 0.94 | FALSE |
21 | The Cancer Genome Atlas | Glioblastoma Multiforme | RPS26 | 0.41 | 0.38 | enet | 9 | 0.39 | 7.9e-13 | -5.4 | -5.4 | 5.9e-08 | 0.63 | 0.45 | 0.55 | FALSE |
22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RPS26 | 0.17 | 0.29 | lasso | 4 | 0.29 | 6.2e-33 | -5.4 | -5.4 | 6.9e-08 | 0.63 | 0.94 | 0.06 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RPS26 | 0.27 | 0.38 | enet | 8 | 0.40 | 5.0e-24 | -5.3 | -5.5 | 4.9e-08 | 0.66 | 0.95 | 0.05 | FALSE |
24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ERBB3 | 0.07 | 0.02 | blup | 29 | 0.05 | 2.1e-06 | -6.5 | -5.4 | 7.0e-08 | 0.39 | 0.00 | 1.00 | FALSE |
25 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS26 | 0.31 | 0.53 | enet | 8 | 0.55 | 1.7e-74 | -5.3 | -5.5 | 4.0e-08 | 0.65 | 0.95 | 0.05 | FALSE |
26 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RPS26 | 0.18 | 0.31 | lasso | 2 | 0.29 | 3.9e-14 | -5.3 | -5.3 | 1.2e-07 | 0.63 | 0.94 | 0.06 | FALSE |
27 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAB5B | 0.03 | 0.02 | enet | 7 | 0.02 | 4.3e-03 | -6.0 | -5.4 | 8.4e-08 | 0.57 | 0.02 | 0.29 | FALSE |
28 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPS26 | 0.26 | 0.45 | enet | 9 | 0.47 | 3.6e-61 | -5.3 | -5.6 | 1.9e-08 | 0.66 | 0.95 | 0.05 | FALSE |
29 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RPS26 | 0.22 | 0.31 | lasso | 3 | 0.31 | 1.6e-35 | -5.3 | -5.6 | 1.6e-08 | 0.65 | 0.95 | 0.05 | TRUE |
30 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RPS26 | 0.30 | 0.20 | lasso | 4 | 0.24 | 3.9e-16 | -5.3 | -5.9 | 4.9e-09 | 0.67 | 0.19 | 0.81 | FALSE |
31 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ESYT1 | 0.16 | 0.02 | blup | 33 | 0.05 | 5.5e-03 | 2.7 | -5.9 | 3.8e-09 | 0.30 | 0.01 | 0.66 | TRUE |
32 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RPS26 | 0.36 | 0.44 | lasso | 7 | 0.42 | 2.4e-19 | -5.4 | -5.2 | 2.0e-07 | 0.64 | 0.96 | 0.04 | FALSE |
33 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RPS26 | 0.47 | 0.43 | lasso | 2 | 0.44 | 3.2e-19 | -5.0 | -5.2 | 2.4e-07 | 0.67 | 0.97 | 0.03 | FALSE |
34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS26 | 0.33 | 0.52 | enet | 9 | 0.54 | 5.6e-66 | -5.3 | -5.6 | 2.2e-08 | 0.65 | 0.95 | 0.05 | FALSE |
35 | The Cancer Genome Atlas | Rectum Adenocarcinoma | RPS26 | 0.24 | 0.18 | lasso | 2 | 0.20 | 1.9e-05 | -5.3 | -5.3 | 1.4e-07 | 0.66 | 0.06 | 0.45 | FALSE |
36 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RPS26 | 0.23 | 0.31 | lasso | 3 | 0.30 | 2.4e-18 | -5.3 | -5.4 | 5.3e-08 | 0.64 | 0.83 | 0.17 | FALSE |
37 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RPS26 | 0.28 | 0.15 | lasso | 2 | 0.17 | 3.0e-05 | -5.9 | -5.8 | 8.1e-09 | 0.69 | 0.02 | 0.94 | FALSE |
38 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RPS26 | 0.19 | 0.32 | lasso | 5 | 0.34 | 2.0e-25 | -5.4 | -5.5 | 3.1e-08 | 0.63 | 0.94 | 0.06 | FALSE |
39 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RPS26 | 0.46 | 0.64 | lasso | 4 | 0.65 | 8.5e-30 | -5.3 | -5.7 | 1.2e-08 | 0.64 | 0.41 | 0.59 | FALSE |
40 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RPS26 | 0.17 | 0.19 | lasso | 4 | 0.18 | 1.3e-05 | -5.3 | -5.3 | 1.2e-07 | 0.67 | 0.07 | 0.90 | FALSE |